LOCUS       gnlProkkaDDPMMDHD_342  15561 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DDPMMDHD_342.
ACCESSION   gnlProkkaDDPMMDHD_342
VERSION     gnlProkkaDDPMMDHD_342
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 04:48:30
            Original ID  :: gnl|Prokka|DDPMMDHD_342
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15561
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15561
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[4243:5401]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4244..5401
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..15561
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15561
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     CDS             complement(73..1068)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 311.2; E-value: 9.5e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.2e-55, bitscore:
                     177.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYGVYQDEVPYIKEWQEEHPEVTVDSTTKLLDENTVNLSKGSDGV
                     VAFQQKPYSDEALRQLALNGITKMSLRNVGVDNLNHELVQELGFQITNVPVYSPAAIAE
                     FSVTQALNLLRRTKEFYLKLAKGDYNWAPHIAKEMNKQVVGIVGTGNIGSTAAKIFAGF
                     GAKVIAYSRHQNKELEGIVEYVSLNELYKRATIISLYLPHVPATDKMLNEKTFAMMQDG
                     VLLVNTARGPLVDEKALIEALNSGKVGGAALDVMTGETKIFNQQINFQEVDYDEFKDLV
                     DRPNVLITPHIAFYTDQAIKNMVKMSLSANLDLIKTGTSDKLVKFPEMSI"
     CDS             complement(1082..1372)
                     /locus_tag="ctg235_2"
                     /transl_table=11
                     /translation="MASEKYYIYVLYCADNSFYCGFTNNVKRRFHTHQTYQGAKYTRVK
                     KRHPLKLIYSEEFESKHDALSAEYYFKHQTRRQKEKFLLDHGVDLLKLRRN"
     CDS             complement(1362..2117)
                     /locus_tag="ctg235_3"
                     /transl_table=11
                     /translation="MENRNILKKDERIDQLYSQDVRIIQNPHYFAFSLDAVLLANFVRP
                     NHRQKLKIVDLCAGNGAIGIFLHDKLGGTFTEVELQPQIADMAERTIMLNDLQDRYTVI
                     NDDIANVNDYISKDSIDIVLCNPPYFPVTAQSQKNPNKALAIARHEIATDLVTVIQKMS
                     GLLKMNGHGYLVHRPDRLGEILQVCQENRLAPKRIQFIHPKPDRDANILLLEVIKDGRP
                     GGVKVVPPLIVHGADNEYTPAVQELLYGK"
     CDS             2119..2850
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141:acyltransferase (Score: 231.4; E-value: 1.4e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_4"
                     /transl_table=11
                     /translation="MSSIIFVLARSTFFRHTEERKLNFVIDWKIDMLYTFLVKIVNPFL
                     NLINGRPKIYNRENIPEGNYIIIAPHRTWMDPVLLALAVWPKKFSFMAKKELFKNPIAS
                     KFLKALNAYPVDRKNPGPSAIKKPVTILKKTDLSTIIFPSGSRYSSKLKGGATVIAKMA
                     NVPLVPAVYQGPLKFGQLFTRKPRQIAFGKPIYIDRKQRLTPEVQTDLEKQMQDAFDQL
                     DRQIDPNYKYIVPPKPKNDEF"
     CDS             complement(2894..3115)
                     /locus_tag="ctg235_5"
                     /transl_table=11
                     /translation="MTIMLMILALLVGLVIGFFGARKYMENYLRNNPPISEEMLRTMML
                     QMGQKPSSRKLHQMMQAMKAQAKKSNRK"
     CDS             complement(3195..3455)
                     /locus_tag="ctg235_6"
                     /transl_table=11
                     /translation="MIIMAESKEQDALLKRINELAHKNKEEGLTEEETKERDRLRKEYL
                     KNFREAMRSNIEMMRIFDKEGKEVTPEKVREIQRKKGLRDD"
     CDS             3575..4201
                     /locus_tag="ctg235_7"
                     /transl_table=11
                     /translation="MAKVAKNKQMAVLNYIHKQVEDHGYPPTVREICSAVGLSSTSTVH
                     GHISRLIEQGFLQKDPSKPRALEITSKGLDILGVKPIQKEIPMLGVVTAGQPILAVENA
                     TEFFPIPPSIQDNNDLFMLTIRGTSMIKAGIFNGDQVIVRKQSTAKNGDIVIAMNDDNE
                     ATCKRFYKEKTRFRLQPENDTMEPIFLDNVKILGKVVGLFRDHIF"
     CDS             complement(4244..5401)
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 534;
                     E-value: 3.5e-162)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg235_8"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 7.3e-09,
                     bitscore: 25.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGIDRMAFATTNDYLDLVELAKERGVDPNKFTIGIGQDLQAVV
                     PPTQDIVTLGATAAKKLLTPELEKNISTVIVATESGIDNSKASAIYIKHLLGLSDFTRT
                     VEMKEACYSATAAIQFAKGVVALNPQETVLVIAADIARYGLNTPGEVTQGAGAVAMLIS
                     RNPHILTLEDTTVAYSKDIMDFWRPLYATEALVDGKYSTNVYIEFFLQTFTRYQQLTGR
                     ELADFAALTFHMPFTKMGKKGLEGLLKDRNDEVAQRLRTQLTASQLFSRQVGNLYTGSL
                     YLSLMSLLQNSDLRAGSRIGLFSYGSGAEGEFYTGILEDGYEHYMNNIQEELKHRHQVS
                     VAEYEKLFSSQLGMNDRDIEFDVTNDPLPFVLKGQKDHQRIYEAK"
     CDS             complement(5427..6095)
                     /locus_tag="ctg235_9"
                     /transl_table=11
                     /translation="MVKKYYAVKKGRHPGIYKTWTECQKEVNGYPNAKFKSFLTLEGAN
                     EWLQTTGNTVTSTKAVNYSDDILVYTDGGSRNHGNKLGQHVKADDKAAWAYFIQTKDQA
                     YTGTAGEFGATNNKMEITALIQALTKLLELGLQDQPITAILDSHYVLDPIMKGWLTNWQ
                     RRGWLTAGGKPVANQKLWEEIVALLPQFPNLHFDWTKGHATNAGNNKVDELLNKTMDQL
                     "
     CDS             complement(6462..7076)
                     /locus_tag="ctg235_10"
                     /transl_table=11
                     /translation="MIFLVIMGALFLILGGFYLANSWQQYREWKSGTIIVVLSIIAIVY
                     GVINLPYFHHNNSASSSQSTSSSQVARSSSFSSFSNGLTIGNSSANEAQQESKTMAVLR
                     QMQKGYSKLGSVDYNEDSKTFQITPTDDNTVEALKALAQDPSQAEQMGWPNLTKSIKSN
                     SGQVEKALGEGYSISIMNPSDSSKALYTAKDDKTTYDIANQ"
     CDS             complement(7188..7706)
                     /locus_tag="ctg235_11"
                     /transl_table=11
                     /translation="MALDLYKYVASVPDYPEKGVIFRDILPLMADGAAFKQATDELVDY
                     AKDKKVDMVVGPEARGFIVGCPIARELGVGFAPARKKGKLPRKAISASYDLEYGTATLQ
                     MEADAIKPGQRVLVVDDLLATGGTISATIDMVEQMGGIVVGCAFLIELKDLHGRDKLKD
                     YDMKALMEF"
     CDS             complement(7723..10050)
                     /locus_tag="ctg235_12"
                     /transl_table=11
                     /translation="MIDAKFKWELADNAPSLTVDNLEKELGISRILATLLAQQGIDSTE
                     QAKKFFEPSMEEIHDPTLLHDMDKAVERIEQAVEKQEQITIYGDYDADGITSTSLMYET
                     LLSIGANVNYYVPNRFTDGYGPNMDAYQRLIDNGTQLFITVDNGVSGKNVINKVMAAGV
                     DVVITDHHELPADLPNAVAIVHPRYPGSNYPFPDLSGVGVAFKVAWALTGEFPVEELDL
                     VAIGEIADVVNVTDENHALISYGIQQLRQGMRPGLAALMKLADIKANNLTDQDIGFGIA
                     PRLNALGRIADANDGVKLLTSLDENESQKLAKEVDQANKERQNLVAEIMKEAEKQANSS
                     ANQQKRTLLIVGKGWHQGVLGIVASRIMNETGKPTIIASTDQNNPTLIKGSGRSVDSFN
                     LFNALEAHCELFTTFGGHPAACGLSFDQKNIVPLQIALEEEAGKQKFDPMVKQPLPIAM
                     KLAPADVTQQLYNDIQRVAPFGPGNMEPVFELNNVKVVDVKTMGQEHQHLKFSIVSDKK
                     NLTVVAFGQGNLATLLSAPTGQINLAVKVSLNEWRGKKTVQLMLEDLQINGTVIIDERT
                     NKLTPQLFSSSDYYIVREPRLRENIAPHVAPGYTLSIEEAIKTDFAGQQVTLVDCPSSE
                     EMLKQIFAEDEGEPATIRLLLYQRKSAYLAGLPTRNDFAQLYRFIYKQKEIKWPMQAKA
                     VSNHLKINMDRLNLMIQVFSEAGFVTIKDDVLKFNEPTNKTDLTQTKRYQKQLAQYKVE
                     QQLLFNDAATVAKWLLEYLNLE"
     CDS             complement(10184..11017)
                     /NRPS_PKS="Domain: PKS_KR (14-168). E-value: 8.5e-11.
                     Score: 33.9. Matches aSDomain:
                     nrpspksdomains_ctg235_13_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     189.4; E-value: 1.3e-57)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_13"
                     /sec_met_domain="adh_short (E-value: 4.1e-33, bitscore:
                     105.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRRVKTLRFLRNEVVLITGGSSGIGKELAFEAARRGAIVVVASR
                     NLEKLQEVAKKCLILSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDF
                     IPVVKESYRSMEKMVHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVY
                     SATKAGVIQFDNVLRMEVADYGVQVLTVNPGPIDTPFFDKADNDYTYRAHLPKWMFISP
                     EDLARRIWNNVGYKTREINVPGYVAYLGWAYQVIPGLGDWAIKKFFDFQQDKKNL"
     aSDomain        complement(10514..10975)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg235_13_PKS_KR.1"
                     /evalue="8.50E-11"
                     /label="ctg235_13_PKS_KR.1"
                     /locus_tag="ctg235_13"
                     /protein_end="168"
                     /protein_start="14"
                     /score="33.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDFIPVVKESYRSMEKM
                     VHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVYSATKA"
     CDS_motif       complement(10829..10975)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg235_13_0001"
                     /evalue="2.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg235_13"
                     /protein_end="63"
                     /protein_start="14"
                     /score="17.2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGR"
     CDS             complement(11034..11963)
                     /locus_tag="ctg235_14"
                     /transl_table=11
                     /translation="MQLEFLGTGAGSPSKQRNVASVALRLLEERNAIWLFDVGEATQHQ
                     ILNTTIRPRKIEKIFITHLHGDHIFGLPGLLSSRSFQGGTEPLTIYGPVGIKRYVQTSL
                     QVSESRLSYPLHFVEITDDGELFNDHGFRVIARKLDHKIACFGYRIEEADHPGELQVEK
                     LREQKVPSGPIYGQLKAGKTVTLPDGRVLDGHDFIGTPQPGRIVAILGDTRQTKNAILL
                     AQNADVLVHESTFAKDETKMAHNYYHSTSKQAAEIAKKAGVKKLLLNHISARYTGKAAY
                     QLAYQVRNIIPDTRVVNDFDVIDIPFKK"
     CDS             complement(11996..13312)
                     /locus_tag="ctg235_15"
                     /transl_table=11
                     /translation="MNMFVDQIKIEVHAGKGGDGMVAFRREKYVPNGGPAGGDGGRGGS
                     IILKVDEGLRTLMDFRYHRIFKAKNGGNGMSKQMTGPSAEDTIIAVPQGTTVRDLDTGE
                     IIGDLVEKDQELVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGEDHYLELELKMLADV
                     GLIGFPSVGKSTLLSVVTGAKPKIAAYEFTTLTPNLGMVMLPDGRDFAMADMPGLIEGA
                     SKGIGLGLKFLRHIERTRVLLHLVDMSSEDPHQAIERYRQINKELANYDPELLKRPQIV
                     VATKMDLPNSADNLAAFKADLVADKTLEKQPEIFPISAVTHQGVQQLMQLTADLLDKTP
                     AFDSESHDKELVAEYRAAAPDKKDEADFTITKDEDGTWVLGGEKLIRLFKMTDLTHEES
                     QLRFARQLRHMGVDDALRAKGVQDGDLVRIEKFVFEFIQ"
     CDS             complement(13377..15188)
                     /locus_tag="ctg235_16"
                     /transl_table=11
                     /translation="MASEHLEHKLALLPDKPGCYLMKNINDQIIYVGKAKNLKNRVRSY
                     FKSSHTGKVAKMVSEVADFETIVTSTNKESFLLEITLIQKHQPYFNIKLKKGTGYPYIK
                     ITNERDPQIKIVSKIKKDGGYYFGPYPNVYAAEETMHFIQKVYPLRRCNGYQGRPCLYY
                     HMGQCLGACFKEVPKSDYEEQIKKIKSFLSGNTATVKRQLTKKMQLAAENMEFERAAEI
                     RDQLHYIEVTVEKQKIISNDKTPRDLFNFYMDKGWLSIQIFFIRQARLMKREKRLFPIV
                     DTAVEEMTSFILQFYNRRNNILPREILLPKGLPNKEISEILGVPVRTPVRGEKRDLLAM
                     AHENAQLSLDEKFRLLEMDQSKTTGAMKEITDALGLPEGHRIEAFDHSHIQGADPVSAM
                     VVFINGEPAKNFYRKYKLKTVINHADEAASTREVIRRRYSRLLKENKPMPDMIFMDGGE
                     IQMDAAKDVLENELGLDIPVIGMVKNDKHQTADLLFGDDDHHINLNPRSQGFYLVQRIQ
                     DEVHRFAITFHRRVHTKHSLSSRLDEIKGVGPRTRTKLLKKYGSITKIAQASVDEIHSL
                     GINRPTAQLIKVSLQKNAEVAKGSSHD"
     CDS             15332..15469
                     /locus_tag="ctg235_17"
                     /transl_table=11
                     /translation="MGLVTRRSEQLDKLFDQFAVDPKKPKATKKNDDKKEKDNKDREKK
                     "
ORIGIN
        1 cactaggcta tcgaactcca tatgaagtat tcatgtctta cgtcactgat gagcaactat
       61 tttctttcta acttaaattg acatttcggg aaatttaact agtttatctg aggtgccagt
      121 tttaatcaaa tctagattgg cagacaaact catcttaacc atatttttga ttgcttgatc
      181 agtataaaaa gcaatatgtg gcgtgattaa aacatttggc cggtcaacta aatctttaaa
      241 ttcgtcataa tcaacttctt ggaaattaat ttgctggtta aaaatcttgg tttcaccagt
      301 cattacgtct agagcagctc ctccgacttt accgctattc aatgcttcaa tcaatgcctt
      361 ttcatcgact aatggtccac gtgcagtgtt aaccagtaag accccgtcct gcatcattgc
      421 aaatgttttt tcattaagca ttttatctgt cgctggaaca tgaggtaaat aaagtgaaat
      481 aattgttgcc cgtttatata attcattaag gctaacgtat tcaacaattc cctctagttc
      541 cttattttgg tgacggctat atgctatcac ttttgcacca aaaccagcaa agattttagc
      601 cgccgtagat ccaatgtttc ctgttccaac tatcccaaca acctgcttat tcatttcctt
      661 agcaatatgc ggtgcccagt tataatctcc ttttgctaac ttcaaataaa attcttttgt
      721 tcgacgtaaa aggttaagtg cttgagtaac tgaaaattca gcaatcgcag ctggggaata
      781 aaccggtaca ttggtaattt gaaaaccaag ttcttgtact aattcatggt taagattatc
      841 aaccccaaca tttcgcaatg acatctttgt aataccatta agtgctaatt gacgtaaggc
      901 ctcgtctgaa taaggctttt gctggaatgc tactactcca tcgcttcctt tagacaagtt
      961 aactgtattt tcatctaaaa gtttcgttgt tgagtctaca gttacttcag gatgttcctc
     1021 ttgccattcc ttaatgtaag gaacttcatc ctgataaaca ccatacatat aaatcttcat
     1081 cttaattcct ccgtagtttc aataaatcga caccatggtc tagtaaaaat ttttcttttt
     1141 ggcggcgggt ttgatgttta aaataatatt ccgcactcag ggcatcatgc tttgattcaa
     1201 attcctctga ataaataagc tttagcggat gacgcttttt cacacgagta tattttgccc
     1261 cttgataagt ctgatgagta tgaaagcgcc gtttaacatt gttggtaaaa ccacaataaa
     1321 agctattatc cgcgcaatac aatacataaa tatagtattt ctcacttgcc atataataac
     1381 tcctgaaccg ctggagtata ctcgttatct gctccatgaa caatcaatgg tggtactact
     1441 tttactccgc caggccgacc atccttaatc acttcaagca acaaaatatt cgcatcacga
     1501 tcaggtttag gatgaataaa ctgaattctt ttaggtgcta atctattttc ctgacacact
     1561 tgcaaaatct cacctaaacg atctggacga tgcacaagat acccatgacc attcattttt
     1621 aataagccac tcattttttg aataactgtc actaaatcag tcgctatttc gtgacgagca
     1681 atcgctaaag ctttatttgg attcttctgg ctttgggctg taactgggaa ataaggagga
     1741 ttacaaagga caatatcaat cgaatcctta gaaatataat cattaacgtt agcaatatca
     1801 tcattaatga cggtataccg atcttgtaaa tcatttagca taattgtccg ttcagccata
     1861 tccgcaatct gtggttgtaa ttcaacttca gtaaatgttc cgccaagctt atcgtggaga
     1921 aaaatgccga tcgccccgtt tccagcgcac aagtcaacaa tttttaattt ctgtcgatga
     1981 ttaggacgca cgaaatttgc taacaagaca gcatctaatg aaaaagcaaa ataatgggga
     2041 ttttggatta tccgtacatc ctgactatat aactgatcaa ttctttcatc cttttttaaa
     2101 atatttctgt tttccattat gtcctccatt atttttgtac ttgcaagatc cacttttttt
     2161 cgtcatactg aggaacgcaa acttaatttt gttatagatt ggaagattga catgttgtac
     2221 actttcctcg ttaaaatcgt taatccattt ttaaatttga ttaacggacg acctaaaata
     2281 tacaatcggg aaaacatccc tgaaggcaat tatattatta ttgcacctca tcgtacttgg
     2341 atggatcctg tcttactagc gcttgccgta tggcccaaaa aatttagctt catggctaaa
     2401 aaagaacttt ttaagaatcc aattgctagc aaattcttaa aagcactaaa tgcctatcca
     2461 gttgatcgga aaaatccagg tccgtctgct attaaaaagc cggttacaat tttaaagaag
     2521 actgacttat cgaccattat tttccctagc ggatcacgct attcatctaa attaaaaggc
     2581 ggggccaccg tgatcgctaa aatggcaaat gtccccttag ttcctgctgt ttaccagggc
     2641 cctctaaaat ttggccagct atttacccgt aaacctcgcc aaatcgcatt tggaaagcct
     2701 atttatattg atcgaaagca acgacttact cctgaagtac agactgattt agaaaagcaa
     2761 atgcaagacg cttttgacca attagataga caaattgatc ccaattataa atatattgtt
     2821 cctccaaagc cgaagaatga tgaattttaa tttccaatat aaaaggatgt gataattatc
     2881 acatcctttt atattattta cgattcgact ttttagcttg tgctttcatc gcttgcatca
     2941 tttgatgtaa tttacgactt gatggttttt gccccatttg aagcatcatc gtccgcagca
     3001 tctcttccga aatcggtgga ttattgcgga ggtagttttc catgtattta cgtgcaccaa
     3061 agaagccgat aaccaaaccg actaataatg caagaatcat tagcatgatc gtcataccca
     3121 caattacttc ctcctttgct cgttacctat ccatcttaca cgaaagagca atttttgaaa
     3181 agagcaaatc gctgttaatc gtcacgaagt ccttttttac gttggatttc acgaaccttt
     3241 tcaggagtaa cttctttccc ttctttatca aaaatccgca tcatttcaat attactacgc
     3301 attgcttctc taaagttctt taggtactcc ttacgtaaac gatctcgttc ttttgtttct
     3361 tcttcagtta agccttcttc tttattctta tgagcaagtt cattaattcg cttcaataaa
     3421 gcatcttgtt ctttagattc agccattata atcatctcct taataaagtc gattttactt
     3481 attttataaa atcaatgcaa atcgcgaacg tacgtttgaa atatgcatct atctatgata
     3541 agcttaacac aattaatgat aatgaggtgt caatatggca aaggtagcaa aaaataaaca
     3601 aatggccgtc ctaaattata ttcacaaaca agttgaagat catggctatc caccgactgt
     3661 tcgtgaaatt tgtagtgctg ttggcctgtc ttcaacttca acagtccatg gacacatctc
     3721 ccgcttaatt gaacaaggat tcttacaaaa agacccttct aagcctcgag cacttgagat
     3781 cacatccaag ggacttgata ttttaggtgt aaaaccgatt caaaaagaaa ttccaatgct
     3841 tggcgttgtt acggctggac aaccaatttt agcagtcgaa aatgctactg agtttttccc
     3901 gatacctcct tctattcaag ataataatga tttgtttatg cttaccattc gtggaaccag
     3961 tatgattaaa gcagggatct ttaatggtga ccaagtaatc gtgcgtaaac aatccaccgc
     4021 taaaaatggt gatatcgtta ttgcaatgaa cgatgataat gaagctactt gtaaacgatt
     4081 ctataaagaa aaaacacgtt ttcgtttaca gccagaaaat gatacgatgg agccaatctt
     4141 cttggacaat gttaaaatcc ttggtaaagt agtgggacta tttcgtgatc atattttcta
     4201 aataaaaaaa ggagtccatt ttgggggctc cttttttatt aggttattta gcttcataaa
     4261 tccgttgatg atccttttgt cctttaagaa cgaaaggcaa tggatcatta gtaacatcaa
     4321 actcgatatc ccgatcattc attcctaatt gactactaaa tagtttttcg tattctgcca
     4381 ctgaaacctg gtgacgatgt tttaattctt cttgaatatt attcatataa tgctcgtagc
     4441 catcttctag gattcctgtg tagaactctc cttctgcacc agaaccatag ctaaataacc
     4501 caattcggct tccagctctt aagtcactat tttgcaacaa tgacattaat gataaatata
     4561 gggaaccagt gtacaggtta ccaacttggc gcgaaaatag ctggcttgcg gttaattgtg
     4621 ttcgtaatcg ttgagctacc tcatcattac gatctttaag caacccttct aaccctttct
     4681 ttcccatttt agtaaatggc atatggaatg taagggcagc aaaatccgct aattctcgcc
     4741 cagttaattg ctgataacgg gtaaaagttt gaaggaagaa ttcaatataa acattagtag
     4801 agtattttcc atctactaaa gcttctgttg catataacgg ccgccaaaag tccattatat
     4861 ccttgctata ggcgacagtt gtatcttcaa gggttaggat gtgagggttc cgtgaaatca
     4921 gcattgcaac tgctccagct ccttgagtca cctctcctgg agtatttaat ccgtaacgag
     4981 caatatcagc agcgatcact aatacagttt cttgaggatt aagcgccact actccctttg
     5041 caaattggat agcagctgtc gcagaataac aagcctcttt catttctacc gttcgggtaa
     5101 agtcgctaag ccctaataag tgtttaatgt agattgcact tgcttttgaa ttgtcaatcc
     5161 ctgactcagt tgccacaatt actgtcgaaa tatttttttc taattccgga gtaagcaatt
     5221 ttttcgctgc cgtagctcct aaagttacaa tatcttgcgt aggtggcaca actgcctgta
     5281 gatcctgtcc aattccaatg gtaaatttat tgggatctac gccgcgttct tttgctaatt
     5341 caacaagatc taaataatca tttgttgttg caaaagccat tctgtcaata ccaattctca
     5401 tttcttatca tcctcttgtt aaataattat aactgatcca tcgttttatt tagtaattca
     5461 tcgaccttat tatttccagc attcgttgca tgacccttag tccaatcaaa atgtaaatta
     5521 gggaactgag gtaaaagggc aacaatttct tcccatagct tctgatttgc taccggtttg
     5581 ccaccagcgg ttaaccatcc ccgccgttgc caattagtta accagccttt cataattggg
     5641 tctagtacgt aatgtgaatc caaaatcgct gtaattggtt gatcttggag gccaagttct
     5701 aatagtttag ttagcgcttg gattaaagct gtaatctcca ttttattatt agtagcccca
     5761 aattcgccag cagttcctgt ataagcttga tctttagttt gaataaaata agcccaggcc
     5821 gctttatcat ctgccttaac gtgctgtccc aacttattgc catgattgcg ggagcctcca
     5881 tcagtataaa caaggatatc atcagaataa ttaactgctt tagtcgatgt tacggtattt
     5941 cccgtagtct gaagccactc attagcaccc tcaagcgtta agaagctttt aaacttagca
     6001 ttcggataac cattaacttc cttctgacat tcagtccaag ttttatatat tcccggatga
     6061 cgaccttttt tgactgcata atattttttt accataaaaa tcccctaatc aaatttcaaa
     6121 ttacatcata tattagaata tcatatcagc aagaaatcat ttctgcaaaa ttattaaata
     6181 gctatttcct taattgatat tctctttacg ctttacaact tttttgttac aataatagag
     6241 ttgaaatgga gacatactca agtggctgaa gaggacggtt tcgaaaaccg ttaggcgtgt
     6301 aaaagcgtgc aggggttcaa atccccttgt ctcctttatc taaagttttg ctgatattca
     6361 atagttgtta aaacgttgat ataccagctt ttttattaca caaaaaagga cacctattaa
     6421 gtgccccaat ctttcttgaa ctaatcttag gttatttagt tttattgatt agcaatatcg
     6481 tatgtggttt tgtcgtcttt ggcagtatac aacgccttac tagaatcact tggattcata
     6541 atgctaattg aatatccttc acctaatgct ttttctactt gccctgaatt acttttaatc
     6601 gacttagtta agttaggcca gcccatttgt tcagcctgac ttggatcttg tgctaaagct
     6661 ttcaatgctt caaccgtatt atcatcagtt ggcgtgatct ggaatgtctt actatcttcg
     6721 ttatagtcaa ctgaacctaa ttttgaatac cccttttgca tttgacgcaa aacagccatt
     6781 gtcttacttt cttgttgcgc ttcatttgca cttgaattac caattgtcaa tccatttgaa
     6841 aatgatgaaa agctactgga ccgcgcaacc tgtgaagatg atgtactttg gcttgagcta
     6901 gcggaattat tatgatgaaa ataaggcaaa ttaatcacac cataaacaat tgcgataata
     6961 ctcaatacaa caatgattgt cccacttttc cattcacggt actgttgcca tgaattagca
     7021 agataaaaac cacccaaaat taaaaatagg gctcccatta ttactaagaa aatcataaat
     7081 taactggctc ctttttatca acgtaatgtt attgtcccgc attcatttta tatatacaac
     7141 tattaattta aaaagaaaaa aggctagtat ccccagcctc ctcctaatta aaattccatt
     7201 aatgccttca tatcgtaatc tttaagctta tcgcgaccat gaagatcttt taattcgatt
     7261 aagaatgcac agccaacaac aataccaccc atttgttcaa ccatatcaat tgttgcagag
     7321 atagttcctc ctgtagctaa gagatcatcc acaacaagaa cccgttgtcc cggtttaatt
     7381 gcatcagctt ccatttgcaa ggtagctgtt ccgtattcta agtcataaga tgcactaatt
     7441 gcttttcttg gcaacttacc ctttttacgt gccggagcaa atccaacacc cagttcacga
     7501 gcaataggac acccaacaat aaagcctcgc gcttctggtc ctactaccat atctaccttt
     7561 ttatccttag cataatcaac taattcgtca gtagcttgct taaaggcagc tccatcagcc
     7621 attaacggta aaatatcccg aaaaataaca cccttttctg gataatcagg aacactagct
     7681 acgtatttat aaaggtctaa agccatgaga taaatagtct ccttattcta aatttagata
     7741 ttccaatagc catttagcaa ccgttgccgc atcattaaaa agcaactgtt gttcaacttt
     7801 atattgtgct aattgttttt gataacgttt agtttgcgtt aaatcagtct tattagttgg
     7861 ctcattaaac tttaacacgt catcttttat tgtaacaaat cctgcttcag aaaacacttg
     7921 aatcattaga tttaatcgat ccatattaat ctttaaatga ttgctaactg ctttagcttg
     7981 catgggccat tttatttctt tttgcttata aataaatcga taaagctgtg caaaatcatt
     8041 ccgtgtcgga agcccagcta aataggcact ttttcgctga tacagtaata agcgaatagt
     8101 tgctggttct ccttcatcct ctgcgaaaat ctgttttagc atttcttcac tagatgggca
     8161 gtcaaccagc gttacttgtt gaccagcaaa atcagtctta attgcttctt cgatcgataa
     8221 agtatagcca ggagccacat ggggagcaat attttcgcgc aatcttggct ctcttacaat
     8281 gtaataatct gaagaactaa aaagctgagg agttagttta ttcgttcgtt catcaataat
     8341 tactgttcca ttgatttgaa ggtcttctaa catcagctgt acggttttct ttccacgcca
     8401 ctcattaagg ctaactttaa cggctaaatt aatttgtccg gttggtgcgg ataatagtgt
     8461 tgctaaattt ccttgaccaa aagcgacgac tgttagattt ttcttatcac ttacaatcga
     8521 aaattttaaa tgctggtgtt cctgtcccat tgttttgaca tcgacaactt taacgttatt
     8581 taattcaaaa accggttcca tatttcctgg accaaatgga gcaacccgtt gaatatcgtt
     8641 atataactgt tgggtaacat cagctggtgc aagtttcatt gcgattggaa gaggttgctt
     8701 taccattgga tcaaattttt gtttgcctgc ttcttcttcc aaggctattt gcagaggtac
     8761 aatatttttc tgatcaaaag aaagaccaca agcagcaggg tgcccaccaa atgttgtaaa
     8821 tagttcacaa tgagcctcca aggcattgaa caaattaaaa ctgtcaacgc ttctaccaga
     8881 tccttttatt aaggtcggat tattttgatc agttgatgcg ataatcgttg gctttccggt
     8941 ctcattcata atccgactgg caacaattcc taatacacct tgatgccaac ctttcccaac
     9001 aattaataag gtccttttct gctggttagc tgagctatta gcctgttttt ctgcttcttt
     9061 cataatctca gcaactaggt tctgacgttc tttattagcc tgatctacct ctttagctaa
     9121 tttttgtgat tcattctcat ctaaactcgt cagcagctta actccatcat tagcatcagc
     9181 aattcggcca agcgcattta gccgtggtgc aattccaaat ccaatatcct gatccgttag
     9241 attgttagct ttaatatcag ctaacttcat taaagccgct aatcccggac gcatcccctg
     9301 ccgtaattgc tgaatgccat aggaaattaa cgcatgattt tcgtccgtaa cgtttactac
     9361 atcagctatt tccccaattg caactaagtc cagttcttca acaggaaact caccagttaa
     9421 agcccaggct accttaaatg caacaccaac gcctgacaaa tcaggaaaag gataattact
     9481 accaggatag cgagggtgaa cgatcgcaac agcattaggc aagtcagcag gcaactcatg
     9541 gtggtcagta attacaacat ctactcctgc tgccattacc ttattgataa cattttttcc
     9601 gctaacgcca ttatccaccg taataaaaag ctgggtacca ttatcaataa gccgttggta
     9661 agcatccatg ttaggcccat atccatctgt aaaacgattt ggcacataat aattaacatt
     9721 agcaccgata gataatagcg tttcatacat taaggatgtg ctagtaattc catcggcatc
     9781 ataatcacca taaatagtaa tttgttcttg cttttcaact gcctgctcaa ttcgctcaac
     9841 tgctttatcc atatcatgca ataaggttgg atcatgaatc tcttccatcg atggttcaaa
     9901 gaactttttt gcttgttcgg ttgaatcgat tccttgctga gctaataagg ttgccaatat
     9961 tctagaaatg cctaactctt tttcaagatt atcaacagtt aatgagggag cattatcggc
    10021 aagttcccac ttaaattttg catcaatcat ttaaaattaa ccaccatttc aacgccaaaa
    10081 ttaaacaaga ggctgggata aactcagtct cttttatttt gcccctttca atttttgaaa
    10141 gaaactgcta aattctgcaa tttctcgaaa ataagggagc atattataag ttcttcttat
    10201 cctgttggaa atcaaaaaat ttcttaattg cccagtcacc taaaccggga ataacttggt
    10261 aagcccagcc aagataagcc acatatcctg gaacattaat ttctctcgtc ttatacccaa
    10321 cattattcca aattcgtcga gctaagtctt caggagagat aaacatccat tttggtaaat
    10381 gggcccgata cgtataatca ttatctgctt tatcaaagaa aggcgtatca attgggccag
    10441 gattgactgt caagacttgg acaccataat cagctacttc cattcgtaaa acattatcaa
    10501 actggattac tccggctttc gttgctgaat atacagcgct atttggtgta ggcaatttac
    10561 cagctaatga acccatatta ataatggcac catacccttg atccatcatt tgtttagcca
    10621 cacaccgact aatatacatt aaggctaaga gattcgtatg taccattttt tccattgagc
    10681 ggtaagattc cttaactacg ggaataaagt caccaagccc agcagaatta attaatacat
    10741 cgattcctcc tacttcatgt tgaaccttcg aaagcacatc atcaatctga tcagggtcgg
    10801 tgacatctaa ttgataagca aatgctggcc gacctgataa aatcagacat tttttagcta
    10861 cctcttgcaa cttctcaaga ttacgagaag caacaacaac aattgcgccg cgacgagctg
    10921 cctcaaaagc caactccttg ccgattccac ttgaaccacc agtaattaat acaacttcat
    10981 ttcgcagaaa acgtaacgtc tttactcttc tcagcatctt ttgccatctc ttttcatttt
    11041 ttgaacggaa tatcaatcac atcaaaatca ttaacaactc gagtatcagg aataatatta
    11101 cgaacttgat atgccaattg ataagctgct ttaccagtgt atcgtgctga aatatgattt
    11161 aacaataatt ttttaacacc agcttttttc gcaatttcag ctgcttgttt actggttgaa
    11221 tggtaataat tgtgtgccat ctttgtctca tctttagcaa aagtactttc atgcactaat
    11281 acatctgcat tttgcgccaa cagaattgca ttcttcgttt gtctagtatc acctagaatt
    11341 gcaacaatac gtccaggttg aggagtgcca ataaagtcat gaccatctaa tactctacca
    11401 tcaggaagag taaccgtttt tccagctttt agttggccgt aaattggccc agatggtact
    11461 ttttgttctc gtaatttttc aacttgtaat tctcctggat gatccgcttc ttcaatccgg
    11521 tagccaaaac aagcgatttt atgatccaac tttcgtgcaa tcactctaaa accatgatca
    11581 ttaaatagtt ctccgtcatc tgttatttca acaaaatgca aaggataact gaggcgtgac
    11641 tcacttactt gcaaagaagt ctgaacatac cgctttatcc ctactggtcc atagatcgtc
    11701 aatggttcgg ttcctccttg aaaagagcgg gaacttagta aaccaggtaa accaaagata
    11761 tgatcaccat gtaagtgagt aataaagatt ttttctatct ttcgtggcct aattgtcgta
    11821 ttgagaattt gatgttgagt agcttctcca acatcaaata accaaattgc gtttcgttct
    11881 tctaacaacc gcaatgcaac acttgctaca ttacgttgct tacttgggga accagcgcct
    11941 gttcctaaaa attcaagttg catttatatt tttcctacct ttgctacgta taattttatt
    12001 gaataaattc aaaaacaaat ttttcaattc ttacaagatc gccatcttgt acacctttag
    12061 ctcttaacgc gtcatcaacc cccatatggc gaagttgacg cgcaaagcgt aattgacttt
    12121 cttcatgagt taaatcagtc atcttaaata atcgaataag tttttcaccg cccaataccc
    12181 aggtgccgtc ttcatccttg gtaatggtaa agtccgcttc atctttcttg tcaggagcag
    12241 cagcacgata ttcagcgacc aattctttat catgactctc actatcaaat gcgggcgtct
    12301 tatctaagag atcagcagtt aattgcatta attgttggac accttgatga gtaaccgctg
    12361 aaatagggaa aatctctggc tgcttttcta aagtcttatc tgctaccaaa tcagctttaa
    12421 aagcagctaa gttatcggca gaatttggca aatccatctt cgtcgcaact acaatttgtg
    12481 gtcgctttaa taattcagga tcgtaattag caagctcttt attaatttgc cggtaacgtt
    12541 caattgcttg atgaggatct tcactactca tatccactag gtgaagaaga acgcgggtac
    12601 gttcaatgtg ccgtaagaac ttcaatccaa ggccgatacc cttcgatgct ccttcaatta
    12661 aaccaggcat gtcagccatc gcaaaatcac ggccatctgg tagcattacc attccgagat
    12721 taggagttaa tgtcgtaaat tcatatgcag caattttagg cttagcaccg gttactactg
    12781 ataataaagt tgactttcca acagaaggga acccaattaa tccgacatca gcaagcatct
    12841 ttaattctaa ttctaagtaa tggtcttctc ctggttcacc attttcagca atttcaggag
    12901 cagggttttt agcactagca aagtgaatgt tgccgcgacc accacggcca cccttggcaa
    12961 ctactaattc ttgatccttt tcaacgagat caccaataat ctcaccagta tcaagatctc
    13021 taacggtagt accttgggga acagcaataa ttgtatcttc tgcacttgga ccagtcatct
    13081 gtttactcat cccattacca ccgtttttag ctttaaaaat tcggtgataa cggaaatcca
    13141 ttaatgtccg taatccttca tcaactttta aaatgatact gccgccacgg ccaccatcgc
    13201 caccagctgg gccaccgtta ggaacatatt tttcacgacg aaatgctacc attccatcgc
    13261 cacctttacc tgcatgtact tcaattttta tttgatcaac aaacatattc ataatgattg
    13321 tctccgttct ttagtctatt atttagtata tttaaaattt ataagcctgt caaaactcaa
    13381 tcatgactac tacccttcgc cacctcagca tttttctgca atgaaacttt gattaactgg
    13441 gcagtaggtc gattaatccc tagtgaatgg atttcatcaa ctgatgcttg agcaattttg
    13501 gtaattgatc catatttttt aagtaatttc gtccgagtcc gcggtcccac tcctttaatt
    13561 tcatccaaac gcgaactcaa cgaatgcttg gtatgaacgc gccggtggaa agtaatcgca
    13621 aaccggtgaa cctcatcttg aatgcgttga actaagtaaa agccttggct acgtggattc
    13681 aaattaatat ggtgatcatc atccccgaac aataagtcag cggtttggtg tttgtcattc
    13741 tttaccatcc ctattacagg aatatcaaga ccaagttcat tctctaaaac atctttagcc
    13801 gcatccatct gaatttcgcc accatccata aaaatcatat ccggcattgg cttgttttct
    13861 tttaagagac gcgaatacct ccgccgaata acttcacggg tactggcagc ttcgtcagca
    13921 tgattaatca ccgttttcaa tttatacttc cggtaaaaat ttttagctgg ttctccatta
    13981 ataaatacaa ccattgcact aacggggtca gccccctgaa tatgagaatg atcaaatgct
    14041 tcaatccggt gaccttctgg aagtccaagt gcatccgtaa tctctttcat cgcaccagta
    14101 gtcttacttt gatccatctc aagcagtcga aatttttcgt ctaaagacaa ctgagcattt
    14161 tcatgtgcca ttgctaaaag atcccgtttt tcaccacgaa caggggtccg aaccggtact
    14221 cctagtattt cacttatttc cttattaggg aggcccttgg ggaggagaat ttcacgaggc
    14281 aaaatattat tacgacgatt ataaaactgg agaataaagc tggtcatttc ttcgactgcc
    14341 gtatccacga ttggaaatag gcgtttttct cgcttcatta accgcgcttg ccggataaag
    14401 aaaatttgaa tagaaagcca ccctttatcc atatagaaat taaataaatc acgaggggtc
    14461 ttatcatttg aaataatctt ttgtttttca accgtcactt caatatagtg aagctggtct
    14521 cgaatttcag cagctcgttc aaactccata ttttctgctg ctagttgcat ctttttggtt
    14581 aactgtcgct taactgtcgc tgtgtttcca ctcaaaaatg acttaatttt cttaatttgc
    14641 tcttcgtagt cacttttagg aacttcttta aaacaagctc ctaaacattg tcccatatgg
    14701 taatacaaac atggacggcc ttgataccca ttacagcggc gcaatgggta gaccttttga
    14761 ataaaatgca ttgtctcttc tgcagcatag acattaggat agggaccaaa ataatatccc
    14821 ccatcttttt ttattttact aacgatctta atttgaggat cccgctcatt tgttattttt
    14881 atgtagggat aaccagttcc cttttttaat ttaatgttga aataaggttg atgtttttga
    14941 atcagcgtta tttcaagtaa gaacgactcc ttattagtcg aagtcacaat ggtttcaaag
    15001 tctgcaactt ccgaaaccat tttagctact ttaccggtat gactactctt aaagtaagag
    15061 cgcactcgat tctttaaatt tttagcttta ccaacataaa ttatctgatc attaatgttt
    15121 ttcatcaggt agcaacctgg cttgtcaggt aacaatgcta gtttatgttc taaatgttca
    15181 ctggccatcg caaaatccct ccgaaaaatt atctaacaat atattatatc tgaaaaatca
    15241 tcattaaggc aaagaaagtg tttagaaata attgtacatt tagtaaaatt tatgctagca
    15301 ttttgtcaaa tataaaaaag gagctaaaaa aatgggatta gttactagaa gaagcgaaca
    15361 gcttgataaa ttatttgatc aatttgcggt tgaccctaaa aaaccaaaag caactaaaaa
    15421 aaacgacgac aaaaaggaaa aagataacaa ggatagagaa aagaaataat cgagtaggag
    15481 ataattgatt agttcaatta tcgacctctc acaccaccgt acgtacggtt ccgtatacgg
    15541 cggttcgaca acttaatcac a
//
