LOCUS       gnlProkkaENPFEMDD_200  15553 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENPFEMDD_200.
ACCESSION   gnlProkkaENPFEMDD_200
VERSION     gnlProkkaENPFEMDD_200
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 04:44:40
            Original ID  :: gnl|Prokka|ENPFEMDD_200
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15553
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15553
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10152:11310]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10153..11310
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..15553
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15553
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     CDS             complement(85..222)
                     /locus_tag="ctg156_1"
                     /transl_table=11
                     /translation="MGLVTRRSEQLDKLFDQFAVDPKKPKATKKNDDKKEKDNKDREKK
                     "
     CDS             366..2177
                     /locus_tag="ctg156_2"
                     /transl_table=11
                     /translation="MASEHLEHKLALLPDKPGCYLMKNINDQIIYVGKAKNLKNRVRSY
                     FKSSHTGKVAKMVSEVADFETIVTSTNKESFLLEITLIQKHQPYFNIKLKKGTGYPYIK
                     ITNERDPQIKIVSKIKKDGGYYFGPYPNVYAAEETMHFIQKVYPLRRCNGYQGRPCLYY
                     HMGQCLGACFKEVPKSDYEEQIKKIKSFLSGNTATVKRQLTKKMQLAAENMEFERAAEI
                     RDQLHYIEVTVEKQKIISNDKTPRDLFNFYMDKGWLSIQIFFIRQARLMKREKRLFPIV
                     DTAVEEMTSFILQFYNRRNNILPREILLPKGLPNKEISEILGVPVRTPVRGEKRDLLAM
                     AHENAQLSLDEKFRLLEMDQSKTTGAMKEITDALGLPEGHRIEAFDHSHIQGADPVSAM
                     VVFINGEPAKNFYRKYKLKTVINHADEAASTREVIRRRYSRLLKENKPMPDMIFMDGGE
                     IQMDAAKDVLENELGLDIPVIGMVKNDKHQTADLLFGDDDHHINLNPRSQGFYLVQRIQ
                     DEVHRFAITFHRRVHTKHSLSSRLDEIKGVGPRTRTKLLKKYGSITKIAQASVDEIHSL
                     GINRPTAQLIKVSLQKNAEVAKGSSHD"
     CDS             2242..3558
                     /locus_tag="ctg156_3"
                     /transl_table=11
                     /translation="MNMFVDQIKIEVHAGKGGDGMVAFRREKYVPNGGPAGGDGGRGGS
                     IILKVDEGLRTLMDFRYHRIFKAKNGGNGMSKQMTGPSAEDTIIAVPQGTTVRDLDTGE
                     IIGDLVEKDQELVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGEDHYLELELKMLADV
                     GLIGFPSVGKSTLLSVVTGAKPKIAAYEFTTLTPNLGMVMLPDGRDFAMADMPGLIEGA
                     SKGIGLGLKFLRHIERTRVLLHLVDMSSEDPHQAIERYRQINKELANYDPELLKRPQIV
                     VATKMDLPNSADNLAAFKADLVADKTLEKQPEIFPISAVTHQGVQQLMQLTADLLDKTP
                     AFDSESHDKELVAEYRAAAPDKKDEADFTITKDEDGTWVLGGEKLIRLFKMTDLTHEES
                     QLRFARQLRHMGVDDALRAKGVQDGDLVRIEKFVFEFIQ"
     CDS             3591..4520
                     /locus_tag="ctg156_4"
                     /transl_table=11
                     /translation="MQLEFLGTGAGSPSKQRNVASVALRLLEERNAIWLFDVGEATQHQ
                     ILNTTIRPRKIEKIFITHLHGDHIFGLPGLLSSRSFQGGTEPLTIYGPVGIKRYVQTSL
                     QVSESRLSYPLHFVEITDDGELFNDHGFRVIARKLDHKIACFGYRIEEADHPGELQVEK
                     LREQKVPSGPIYGQLKAGKTVTLPDGRVLDGHDFIGTPQPGRIVAILGDTRQTKNAILL
                     AQNADVLVHESTFAKDETKMAHNYYHSTSKQAAEIAKKAGVKKLLLNHISARYTGKAAY
                     QLAYQVRNIIPDTRVVNDFDVIDIPFKK"
     CDS             4537..5370
                     /NRPS_PKS="Domain: PKS_KR (14-168). E-value: 8.5e-11.
                     Score: 33.9. Matches aSDomain:
                     nrpspksdomains_ctg156_5_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     189.4; E-value: 1.3e-57)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg156_5"
                     /sec_met_domain="adh_short (E-value: 4.1e-33, bitscore:
                     105.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRRVKTLRFLRNEVVLITGGSSGIGKELAFEAARRGAIVVVASR
                     NLEKLQEVAKKCLILSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDF
                     IPVVKESYRSMEKMVHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVY
                     SATKAGVIQFDNVLRMEVADYGVQVLTVNPGPIDTPFFDKADNDYTYRAHLPKWMFISP
                     EDLARRIWNNVGYKTREINVPGYVAYLGWAYQVIPGLGDWAIKKFFDFQQDKKNL"
     CDS_motif       4579..4725
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg156_5_0001"
                     /evalue="2.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg156_5"
                     /protein_end="63"
                     /protein_start="14"
                     /score="17.2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGR"
     aSDomain        4579..5040
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg156_5_PKS_KR.1"
                     /evalue="8.50E-11"
                     /label="ctg156_5_PKS_KR.1"
                     /locus_tag="ctg156_5"
                     /protein_end="168"
                     /protein_start="14"
                     /score="33.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDFIPVVKESYRSMEKM
                     VHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVYSATKA"
     CDS             5504..7831
                     /locus_tag="ctg156_6"
                     /transl_table=11
                     /translation="MIDAKFKWELADNAPSLTVDNLEKELGISRILATLLAQQGIDSTE
                     QAKKFFEPSMEEIHDPTLLHDMDKAVERIEQAVEKQEQITIYGDYDADGITSTSLMYET
                     LLSIGANVNYYVPNRFTDGYGPNMDAYQRLIDNGTQLFITVDNGVSGKNVINKVMAAGV
                     DVVITDHHELPADLPNAVAIVHPRYPGSNYPFPDLSGVGVAFKVAWALTGEFPVEELDL
                     VAIGEIADVVNVTDENHALISYGIQQLRQGMRPGLAALMKLADIKANNLTDQDIGFGIA
                     PRLNALGRIADANDGVKLLTSLDENESQKLAKEVDQANKERQNLVAEIMKEAEKQANSS
                     ANQQKRTLLIVGKGWHQGVLGIVASRIMNETGKPTIIASTDQNNPTLIKGSGRSVDSFN
                     LFNALEAHCELFTTFGGHPAACGLSFDQKNIVPLQIALEEEAGKQKFDPMVKQPLPIAM
                     KLAPADVTQQLYNDIQRVAPFGPGNMEPVFELNNVKVVDVKTMGQEHQHLKFSIVSDKK
                     NLTVVAFGQGNLATLLSAPTGQINLAVKVSLNEWRGKKTVQLMLEDLQINGTVIIDERT
                     NKLTPQLFSSSDYYIVREPRLRENIAPHVAPGYTLSIEEAIKTDFAGQQVTLVDCPSSE
                     EMLKQIFAEDEGEPATIRLLLYQRKSAYLAGLPTRNDFAQLYRFIYKQKEIKWPMQAKA
                     VSNHLKINMDRLNLMIQVFSEAGFVTIKDDVLKFNEPTNKTDLTQTKRYQKQLAQYKVE
                     QQLLFNDAATVAKWLLEYLNLE"
     CDS             7848..8366
                     /locus_tag="ctg156_7"
                     /transl_table=11
                     /translation="MALDLYKYVASVPDYPEKGVIFRDILPLMADGAAFKQATDELVDY
                     AKDKKVDMVVGPEARGFIVGCPIARELGVGFAPARKKGKLPRKAISASYDLEYGTATLQ
                     MEADAIKPGQRVLVVDDLLATGGTISATIDMVEQMGGIVVGCAFLIELKDLHGRDKLKD
                     YDMKALMEF"
     CDS             8478..9092
                     /locus_tag="ctg156_8"
                     /transl_table=11
                     /translation="MIFLVIMGALFLILGGFYLANSWQQYREWKSGTIIVVLSIIAIVY
                     GVINLPYFHHNNSASSSQSTSSSQVARSSSFSSFSNGLTIGNSSANEAQQESKTMAVLR
                     QMQKGYSKLGSVDYNEDSKTFQITPTDDNTVEALKALAQDPSQAEQMGWPNLTKSIKSN
                     SGQVEKALGEGYSISIMNPSDSSKALYTAKDDKTTYDIANQ"
     CDS             9459..10127
                     /locus_tag="ctg156_9"
                     /transl_table=11
                     /translation="MVKKYYAVKKGRHPGIYKTWTECQKEVNGYPNAKFKSFLTLEGAN
                     EWLQTTGNTVTSTKAVNYSDDILVYTDGGSRNHGNKLGQHVKADDKAAWAYFIQTKDQA
                     YTGTAGEFGATNNKMEITALIQALTKLLELGLQDQPITAILDSHYVLDPIMKGWLTNWQ
                     RRGWLTAGGKPVANQKLWEEIVALLPQFPNLHFDWTKGHATNAGNNKVDELLNKTMDQL
                     "
     CDS             10153..11310
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 534;
                     E-value: 3.5e-162)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg156_10"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 7.3e-09,
                     bitscore: 25.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGIDRMAFATTNDYLDLVELAKERGVDPNKFTIGIGQDLQAVV
                     PPTQDIVTLGATAAKKLLTPELEKNISTVIVATESGIDNSKASAIYIKHLLGLSDFTRT
                     VEMKEACYSATAAIQFAKGVVALNPQETVLVIAADIARYGLNTPGEVTQGAGAVAMLIS
                     RNPHILTLEDTTVAYSKDIMDFWRPLYATEALVDGKYSTNVYIEFFLQTFTRYQQLTGR
                     ELADFAALTFHMPFTKMGKKGLEGLLKDRNDEVAQRLRTQLTASQLFSRQVGNLYTGSL
                     YLSLMSLLQNSDLRAGSRIGLFSYGSGAEGEFYTGILEDGYEHYMNNIQEELKHRHQVS
                     VAEYEKLFSSQLGMNDRDIEFDVTNDPLPFVLKGQKDHQRIYEAK"
     CDS             complement(11353..11979)
                     /locus_tag="ctg156_11"
                     /transl_table=11
                     /translation="MAKVAKNKQMAVLNYIHKQVEDHGYPPTVREICSAVGLSSTSTVH
                     GHISRLIEQGFLQKDPSKPRALEITSKGLDILGVKPIQKEIPMLGVVTAGQPILAVENA
                     TEFFPIPPSIQDNNDLFMLTIRGTSMIKAGIFNGDQVIVRKQSTAKNGDIVIAMNDDNE
                     ATCKRFYKEKTRFRLQPENDTMEPIFLDNVKILGKVVGLFRDHIF"
     CDS             12099..12359
                     /locus_tag="ctg156_12"
                     /transl_table=11
                     /translation="MIIMAESKEQDALLKRINELAHKNKEEGLTEEETKERDRLRKEYL
                     KNFREAMRSNIEMMRIFDKEGKEVTPEKVREIQRKKGLRDD"
     CDS             12439..12660
                     /locus_tag="ctg156_13"
                     /transl_table=11
                     /translation="MTIMLMILALLVGLVIGFFGARKYMENYLRNNPPISEEMLRTMML
                     QMGQKPSSRKLHQMMQAMKAQAKKSNRK"
     CDS             complement(12704..13435)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141:acyltransferase (Score: 231.4; E-value: 1.4e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg156_14"
                     /transl_table=11
                     /translation="MSSIIFVLARSTFFRHTEERKLNFVIDWKIDMLYTFLVKIVNPFL
                     NLINGRPKIYNRENIPEGNYIIIAPHRTWMDPVLLALAVWPKKFSFMAKKELFKNPIAS
                     KFLKALNAYPVDRKNPGPSAIKKPVTILKKTDLSTIIFPSGSRYSSKLKGGATVIAKMA
                     NVPLVPAVYQGPLKFGQLFTRKPRQIAFGKPIYIDRKQRLTPEVQTDLEKQMQDAFDQL
                     DRQIDPNYKYIVPPKPKNDEF"
     CDS             13437..14192
                     /locus_tag="ctg156_15"
                     /transl_table=11
                     /translation="MENRNILKKDERIDQLYSQDVRIIQNPHYFAFSLDAVLLANFVRP
                     NHRQKLKIVDLCAGNGAIGIFLHDKLGGTFTEVELQPQIADMAERTIMLNDLQDRYTVI
                     NDDIANVNDYISKDSIDIVLCNPPYFPVTAQSQKNPNKALAIARHEIATDLVTVIQKMS
                     GLLKMNGHGYLVHRPDRLGEILQVCQENRLAPKRIQFIHPKPDRDANILLLEVIKDGRP
                     GGVKVVPPLIVHGADNEYTPAVQELLYGK"
     CDS             14182..14472
                     /locus_tag="ctg156_16"
                     /transl_table=11
                     /translation="MASEKYYIYVLYCADNSFYCGFTNNVKRRFHTHQTYQGAKYTRVK
                     KRHPLKLIYSEEFESKHDALSAEYYFKHQTRRQKEKFLLDHGVDLLKLRRN"
     CDS             14486..15481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 311.2; E-value: 9.5e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg156_17"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.2e-55, bitscore:
                     177.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYGVYQDEVPYIKEWQEEHPEVTVDSTTKLLDENTVNLSKGSDGV
                     VAFQQKPYSDEALRQLALNGITKMSLRNVGVDNLNHELVQELGFQITNVPVYSPAAIAE
                     FSVTQALNLLRRTKEFYLKLAKGDYNWAPHIAKEMNKQVVGIVGTGNIGSTAAKIFAGF
                     GAKVIAYSRHQNKELEGIVEYVSLNELYKRATIISLYLPHVPATDKMLNEKTFAMMQDG
                     VLLVNTARGPLVDEKALIEALNSGKVGGAALDVMTGETKIFNQQINFQEVDYDEFKDLV
                     DRPNVLITPHIAFYTDQAIKNMVKMSLSANLDLIKTGTSDKLVKFPEMSI"
ORIGIN
        1 agttgtcgaa ccgccgtata cggaaccgta cgtacggtgg tgtgagaggt cgataattga
       61 actaatcaat tatctcctac tcgattattt cttttctcta tccttgttat ctttttcctt
      121 tttgtcgtcg ttttttttag ttgcttttgg ttttttaggg tcaaccgcaa attgatcaaa
      181 taatttatca agctgttcgc ttcttctagt aactaatccc atttttttag ctcctttttt
      241 atatttgaca aaatgctagc ataaatttta ctaaatgtac aattatttct aaacactttc
      301 tttgccttaa tgatgatttt tcagatataa tatattgtta gataattttt cggagggatt
      361 ttgcgatggc cagtgaacat ttagaacata aactagcatt gttacctgac aagccaggtt
      421 gctacctgat gaaaaacatt aatgatcaga taatttatgt tggtaaagct aaaaatttaa
      481 agaatcgagt gcgctcttac tttaagagta gtcataccgg taaagtagct aaaatggttt
      541 cggaagttgc agactttgaa accattgtga cttcgactaa taaggagtcg ttcttacttg
      601 aaataacgct gattcaaaaa catcaacctt atttcaacat taaattaaaa aagggaactg
      661 gttatcccta cataaaaata acaaatgagc gggatcctca aattaagatc gttagtaaaa
      721 taaaaaaaga tgggggatat tattttggtc cctatcctaa tgtctatgct gcagaagaga
      781 caatgcattt tattcaaaag gtctacccat tgcgccgctg taatgggtat caaggccgtc
      841 catgtttgta ttaccatatg ggacaatgtt taggagcttg ttttaaagaa gttcctaaaa
      901 gtgactacga agagcaaatt aagaaaatta agtcattttt gagtggaaac acagcgacag
      961 ttaagcgaca gttaaccaaa aagatgcaac tagcagcaga aaatatggag tttgaacgag
     1021 ctgctgaaat tcgagaccag cttcactata ttgaagtgac ggttgaaaaa caaaagatta
     1081 tttcaaatga taagacccct cgtgatttat ttaatttcta tatggataaa gggtggcttt
     1141 ctattcaaat tttctttatc cggcaagcgc ggttaatgaa gcgagaaaaa cgcctatttc
     1201 caatcgtgga tacggcagtc gaagaaatga ccagctttat tctccagttt tataatcgtc
     1261 gtaataatat tttgcctcgt gaaattctcc tccccaaggg cctccctaat aaggaaataa
     1321 gtgaaatact aggagtaccg gttcggaccc ctgttcgtgg tgaaaaacgg gatcttttag
     1381 caatggcaca tgaaaatgct cagttgtctt tagacgaaaa atttcgactg cttgagatgg
     1441 atcaaagtaa gactactggt gcgatgaaag agattacgga tgcacttgga cttccagaag
     1501 gtcaccggat tgaagcattt gatcattctc atattcaggg ggctgacccc gttagtgcaa
     1561 tggttgtatt tattaatgga gaaccagcta aaaattttta ccggaagtat aaattgaaaa
     1621 cggtgattaa tcatgctgac gaagctgcca gtacccgtga agttattcgg cggaggtatt
     1681 cgcgtctctt aaaagaaaac aagccaatgc cggatatgat ttttatggat ggtggcgaaa
     1741 ttcagatgga tgcggctaaa gatgttttag agaatgaact tggtcttgat attcctgtaa
     1801 tagggatggt aaagaatgac aaacaccaaa ccgctgactt attgttcggg gatgatgatc
     1861 accatattaa tttgaatcca cgtagccaag gcttttactt agttcaacgc attcaagatg
     1921 aggttcaccg gtttgcgatt actttccacc ggcgcgttca taccaagcat tcgttgagtt
     1981 cgcgtttgga tgaaattaaa ggagtgggac cgcggactcg gacgaaatta cttaaaaaat
     2041 atggatcaat taccaaaatt gctcaagcat cagttgatga aatccattca ctagggatta
     2101 atcgacctac tgcccagtta atcaaagttt cattgcagaa aaatgctgag gtggcgaagg
     2161 gtagtagtca tgattgagtt ttgacaggct tataaatttt aaatatacta aataatagac
     2221 taaagaacgg agacaatcat tatgaatatg tttgttgatc aaataaaaat tgaagtacat
     2281 gcaggtaaag gtggcgatgg aatggtagca tttcgtcgtg aaaaatatgt tcctaacggt
     2341 ggcccagctg gtggcgatgg tggccgtggc ggcagtatca ttttaaaagt tgatgaagga
     2401 ttacggacat taatggattt ccgttatcac cgaattttta aagctaaaaa cggtggtaat
     2461 gggatgagta aacagatgac tggtccaagt gcagaagata caattattgc tgttccccaa
     2521 ggtactaccg ttagagatct tgatactggt gagattattg gtgatctcgt tgaaaaggat
     2581 caagaattag tagttgccaa gggtggccgt ggtggtcgcg gcaacattca ctttgctagt
     2641 gctaaaaacc ctgctcctga aattgctgaa aatggtgaac caggagaaga ccattactta
     2701 gaattagaat taaagatgct tgctgatgtc ggattaattg ggttcccttc tgttggaaag
     2761 tcaactttat tatcagtagt aaccggtgct aagcctaaaa ttgctgcata tgaatttacg
     2821 acattaactc ctaatctcgg aatggtaatg ctaccagatg gccgtgattt tgcgatggct
     2881 gacatgcctg gtttaattga aggagcatcg aagggtatcg gccttggatt gaagttctta
     2941 cggcacattg aacgtacccg cgttcttctt cacctagtgg atatgagtag tgaagatcct
     3001 catcaagcaa ttgaacgtta ccggcaaatt aataaagagc ttgctaatta cgatcctgaa
     3061 ttattaaagc gaccacaaat tgtagttgcg acgaagatgg atttgccaaa ttctgccgat
     3121 aacttagctg cttttaaagc tgatttggta gcagataaga ctttagaaaa gcagccagag
     3181 attttcccta tttcagcggt tactcatcaa ggtgtccaac aattaatgca attaactgct
     3241 gatctcttag ataagacgcc cgcatttgat agtgagagtc atgataaaga attggtcgct
     3301 gaatatcgtg ctgctgctcc tgacaagaaa gatgaagcgg actttaccat taccaaggat
     3361 gaagacggca cctgggtatt gggcggtgaa aaacttattc gattatttaa gatgactgat
     3421 ttaactcatg aagaaagtca attacgcttt gcgcgtcaac ttcgccatat gggggttgat
     3481 gacgcgttaa gagctaaagg tgtacaagat ggcgatcttg taagaattga aaaatttgtt
     3541 tttgaattta ttcaataaaa ttatacgtag caaaggtagg aaaaatataa atgcaacttg
     3601 aatttttagg aacaggcgct ggttccccaa gtaagcaacg taatgtagca agtgttgcat
     3661 tgcggttgtt agaagaacga aacgcaattt ggttatttga tgttggagaa gctactcaac
     3721 atcaaattct caatacgaca attaggccac gaaagataga aaaaatcttt attactcact
     3781 tacatggtga tcatatcttt ggtttacctg gtttactaag ttcccgctct tttcaaggag
     3841 gaaccgaacc attgacgatc tatggaccag tagggataaa gcggtatgtt cagacttctt
     3901 tgcaagtaag tgagtcacgc ctcagttatc ctttgcattt tgttgaaata acagatgacg
     3961 gagaactatt taatgatcat ggttttagag tgattgcacg aaagttggat cataaaatcg
     4021 cttgttttgg ctaccggatt gaagaagcgg atcatccagg agaattacaa gttgaaaaat
     4081 tacgagaaca aaaagtacca tctgggccaa tttacggcca actaaaagct ggaaaaacgg
     4141 ttactcttcc tgatggtaga gtattagatg gtcatgactt tattggcact cctcaacctg
     4201 gacgtattgt tgcaattcta ggtgatacta gacaaacgaa gaatgcaatt ctgttggcgc
     4261 aaaatgcaga tgtattagtg catgaaagta cttttgctaa agatgagaca aagatggcac
     4321 acaattatta ccattcaacc agtaaacaag cagctgaaat tgcgaaaaaa gctggtgtta
     4381 aaaaattatt gttaaatcat atttcagcac gatacactgg taaagcagct tatcaattgg
     4441 catatcaagt tcgtaatatt attcctgata ctcgagttgt taatgatttt gatgtgattg
     4501 atattccgtt caaaaaatga aaagagatgg caaaagatgc tgagaagagt aaagacgtta
     4561 cgttttctgc gaaatgaagt tgtattaatt actggtggtt caagtggaat cggcaaggag
     4621 ttggcttttg aggcagctcg tcgcggcgca attgttgttg ttgcttctcg taatcttgag
     4681 aagttgcaag aggtagctaa aaaatgtctg attttatcag gtcggccagc atttgcttat
     4741 caattagatg tcaccgaccc tgatcagatt gatgatgtgc tttcgaaggt tcaacatgaa
     4801 gtaggaggaa tcgatgtatt aattaattct gctgggcttg gtgactttat tcccgtagtt
     4861 aaggaatctt accgctcaat ggaaaaaatg gtacatacga atctcttagc cttaatgtat
     4921 attagtcggt gtgtggctaa acaaatgatg gatcaagggt atggtgccat tattaatatg
     4981 ggttcattag ctggtaaatt gcctacacca aatagcgctg tatattcagc aacgaaagcc
     5041 ggagtaatcc agtttgataa tgttttacga atggaagtag ctgattatgg tgtccaagtc
     5101 ttgacagtca atcctggccc aattgatacg cctttctttg ataaagcaga taatgattat
     5161 acgtatcggg cccatttacc aaaatggatg tttatctctc ctgaagactt agctcgacga
     5221 atttggaata atgttgggta taagacgaga gaaattaatg ttccaggata tgtggcttat
     5281 cttggctggg cttaccaagt tattcccggt ttaggtgact gggcaattaa gaaatttttt
     5341 gatttccaac aggataagaa gaacttataa tatgctccct tattttcgag aaattgcaga
     5401 atttagcagt ttctttcaaa aattgaaagg ggcaaaataa aagagactga gtttatccca
     5461 gcctcttgtt taattttggc gttgaaatgg tggttaattt taaatgattg atgcaaaatt
     5521 taagtgggaa cttgccgata atgctccctc attaactgtt gataatcttg aaaaagagtt
     5581 aggcatttct agaatattgg caaccttatt agctcagcaa ggaatcgatt caaccgaaca
     5641 agcaaaaaag ttctttgaac catcgatgga agagattcat gatccaacct tattgcatga
     5701 tatggataaa gcagttgagc gaattgagca ggcagttgaa aagcaagaac aaattactat
     5761 ttatggtgat tatgatgccg atggaattac tagcacatcc ttaatgtatg aaacgctatt
     5821 atctatcggt gctaatgtta attattatgt gccaaatcgt tttacagatg gatatgggcc
     5881 taacatggat gcttaccaac ggcttattga taatggtacc cagcttttta ttacggtgga
     5941 taatggcgtt agcggaaaaa atgttatcaa taaggtaatg gcagcaggag tagatgttgt
     6001 aattactgac caccatgagt tgcctgctga cttgcctaat gctgttgcga tcgttcaccc
     6061 tcgctatcct ggtagtaatt atccttttcc tgatttgtca ggcgttggtg ttgcatttaa
     6121 ggtagcctgg gctttaactg gtgagtttcc tgttgaagaa ctggacttag ttgcaattgg
     6181 ggaaatagct gatgtagtaa acgttacgga cgaaaatcat gcgttaattt cctatggcat
     6241 tcagcaatta cggcagggga tgcgtccggg attagcggct ttaatgaagt tagctgatat
     6301 taaagctaac aatctaacgg atcaggatat tggatttgga attgcaccac ggctaaatgc
     6361 gcttggccga attgctgatg ctaatgatgg agttaagctg ctgacgagtt tagatgagaa
     6421 tgaatcacaa aaattagcta aagaggtaga tcaggctaat aaagaacgtc agaacctagt
     6481 tgctgagatt atgaaagaag cagaaaaaca ggctaatagc tcagctaacc agcagaaaag
     6541 gaccttatta attgttggga aaggttggca tcaaggtgta ttaggaattg ttgccagtcg
     6601 gattatgaat gagaccggaa agccaacgat tatcgcatca actgatcaaa ataatccgac
     6661 cttaataaaa ggatctggta gaagcgttga cagttttaat ttgttcaatg ccttggaggc
     6721 tcattgtgaa ctatttacaa catttggtgg gcaccctgct gcttgtggtc tttcttttga
     6781 tcagaaaaat attgtacctc tgcaaatagc cttggaagaa gaagcaggca aacaaaaatt
     6841 tgatccaatg gtaaagcaac ctcttccaat cgcaatgaaa cttgcaccag ctgatgttac
     6901 ccaacagtta tataacgata ttcaacgggt tgctccattt ggtccaggaa atatggaacc
     6961 ggtttttgaa ttaaataacg ttaaagttgt cgatgtcaaa acaatgggac aggaacacca
     7021 gcatttaaaa ttttcgattg taagtgataa gaaaaatcta acagtcgtcg cttttggtca
     7081 aggaaattta gcaacactat tatccgcacc aaccggacaa attaatttag ccgttaaagt
     7141 tagccttaat gagtggcgtg gaaagaaaac cgtacagctg atgttagaag accttcaaat
     7201 caatggaaca gtaattattg atgaacgaac gaataaacta actcctcagc tttttagttc
     7261 ttcagattat tacattgtaa gagagccaag attgcgcgaa aatattgctc cccatgtggc
     7321 tcctggctat actttatcga tcgaagaagc aattaagact gattttgctg gtcaacaagt
     7381 aacgctggtt gactgcccat ctagtgaaga aatgctaaaa cagattttcg cagaggatga
     7441 aggagaacca gcaactattc gcttattact gtatcagcga aaaagtgcct atttagctgg
     7501 gcttccgaca cggaatgatt ttgcacagct ttatcgattt atttataagc aaaaagaaat
     7561 aaaatggccc atgcaagcta aagcagttag caatcattta aagattaata tggatcgatt
     7621 aaatctaatg attcaagtgt tttctgaagc aggatttgtt acaataaaag atgacgtgtt
     7681 aaagtttaat gagccaacta ataagactga tttaacgcaa actaaacgtt atcaaaaaca
     7741 attagcacaa tataaagttg aacaacagtt gctttttaat gatgcggcaa cggttgctaa
     7801 atggctattg gaatatctaa atttagaata aggagactat ttatctcatg gctttagacc
     7861 tttataaata cgtagctagt gttcctgatt atccagaaaa gggtgttatt tttcgggata
     7921 ttttaccgtt aatggctgat ggagctgcct ttaagcaagc tactgacgaa ttagttgatt
     7981 atgctaagga taaaaaggta gatatggtag taggaccaga agcgcgaggc tttattgttg
     8041 ggtgtcctat tgctcgtgaa ctgggtgttg gatttgctcc ggcacgtaaa aagggtaagt
     8101 tgccaagaaa agcaattagt gcatcttatg acttagaata cggaacagct accttgcaaa
     8161 tggaagctga tgcaattaaa ccgggacaac gggttcttgt tgtggatgat ctcttagcta
     8221 caggaggaac tatctctgca acaattgata tggttgaaca aatgggtggt attgttgttg
     8281 gctgtgcatt cttaatcgaa ttaaaagatc ttcatggtcg cgataagctt aaagattacg
     8341 atatgaaggc attaatggaa ttttaattag gaggaggctg gggatactag ccttttttct
     8401 ttttaaatta atagttgtat atataaaatg aatgcgggac aataacatta cgttgataaa
     8461 aaggagccag ttaatttatg attttcttag taataatggg agccctattt ttaattttgg
     8521 gtggttttta tcttgctaat tcatggcaac agtaccgtga atggaaaagt gggacaatca
     8581 ttgttgtatt gagtattatc gcaattgttt atggtgtgat taatttgcct tattttcatc
     8641 ataataattc cgctagctca agccaaagta catcatcttc acaggttgcg cggtccagta
     8701 gcttttcatc attttcaaat ggattgacaa ttggtaattc aagtgcaaat gaagcgcaac
     8761 aagaaagtaa gacaatggct gttttgcgtc aaatgcaaaa ggggtattca aaattaggtt
     8821 cagttgacta taacgaagat agtaagacat tccagatcac gccaactgat gataatacgg
     8881 ttgaagcatt gaaagcttta gcacaagatc caagtcaggc tgaacaaatg ggctggccta
     8941 acttaactaa gtcgattaaa agtaattcag ggcaagtaga aaaagcatta ggtgaaggat
     9001 attcaattag cattatgaat ccaagtgatt ctagtaaggc gttgtatact gccaaagacg
     9061 acaaaaccac atacgatatt gctaatcaat aaaactaaat aacctaagat tagttcaaga
     9121 aagattgggg cacttaatag gtgtcctttt ttgtgtaata aaaaagctgg tatatcaacg
     9181 ttttaacaac tattgaatat cagcaaaact ttagataaag gagacaaggg gatttgaacc
     9241 cctgcacgct tttacacgcc taacggtttt cgaaaccgtc ctcttcagcc acttgagtat
     9301 gtctccattt caactctatt attgtaacaa aaaagttgta aagcgtaaag agaatatcaa
     9361 ttaaggaaat agctatttaa taattttgca gaaatgattt cttgctgata tgatattcta
     9421 atatatgatg taatttgaaa tttgattagg ggatttttat ggtaaaaaaa tattatgcag
     9481 tcaaaaaagg tcgtcatccg ggaatatata aaacttggac tgaatgtcag aaggaagtta
     9541 atggttatcc gaatgctaag tttaaaagct tcttaacgct tgagggtgct aatgagtggc
     9601 ttcagactac gggaaatacc gtaacatcga ctaaagcagt taattattct gatgatatcc
     9661 ttgtttatac tgatggaggc tcccgcaatc atggcaataa gttgggacag cacgttaagg
     9721 cagatgataa agcggcctgg gcttatttta ttcaaactaa agatcaagct tatacaggaa
     9781 ctgctggcga atttggggct actaataata aaatggagat tacagcttta atccaagcgc
     9841 taactaaact attagaactt ggcctccaag atcaaccaat tacagcgatt ttggattcac
     9901 attacgtact agacccaatt atgaaaggct ggttaactaa ttggcaacgg cggggatggt
     9961 taaccgctgg tggcaaaccg gtagcaaatc agaagctatg ggaagaaatt gttgcccttt
    10021 tacctcagtt ccctaattta cattttgatt ggactaaggg tcatgcaacg aatgctggaa
    10081 ataataaggt cgatgaatta ctaaataaaa cgatggatca gttataatta tttaacaaga
    10141 ggatgataag aaatgagaat tggtattgac agaatggctt ttgcaacaac aaatgattat
    10201 ttagatcttg ttgaattagc aaaagaacgc ggcgtagatc ccaataaatt taccattgga
    10261 attggacagg atctacaggc agttgtgcca cctacgcaag atattgtaac tttaggagct
    10321 acggcagcga aaaaattgct tactccggaa ttagaaaaaa atatttcgac agtaattgtg
    10381 gcaactgagt cagggattga caattcaaaa gcaagtgcaa tctacattaa acacttatta
    10441 gggcttagcg actttacccg aacggtagaa atgaaagagg cttgttattc tgcgacagct
    10501 gctatccaat ttgcaaaggg agtagtggcg cttaatcctc aagaaactgt attagtgatc
    10561 gctgctgata ttgctcgtta cggattaaat actccaggag aggtgactca aggagctgga
    10621 gcagttgcaa tgctgatttc acggaaccct cacatcctaa cccttgaaga tacaaccgtc
    10681 gcttatagca aggatataat ggacttttgg cggccgttat atgcaacaga agctttagta
    10741 gatggaaaat actctactaa tgtttatatt gaattcttcc ttcaaacttt tacccgttat
    10801 cagcaattaa ctgggcgaga attagcggat tttgctgccc ttacattcca tatgccattt
    10861 actaaaatgg gaaagaaagg gttagaaggg ttgcttaaag atcgtaatga tgaggtagct
    10921 caacgattac gaacacaatt aaccgcaagc cagctatttt cgcgccaagt tggtaacctg
    10981 tacactggtt ccctatattt atcattaatg tcattgttgc aaaatagtga cttaagagct
    11041 ggaagccgaa ttgggttatt tagctatggt tctggtgcag aaggagagtt ctacacagga
    11101 atcctagaag atggctacga gcattatatg aataatattc aagaagaatt aaaacatcgt
    11161 caccaggttt cagtggcaga atacgaaaaa ctatttagta gtcaattagg aatgaatgat
    11221 cgggatatcg agtttgatgt tactaatgat ccattgcctt tcgttcttaa aggacaaaag
    11281 gatcatcaac ggatttatga agctaaataa cctaataaaa aaggagcccc caaaatggac
    11341 tccttttttt atttagaaaa tatgatcacg aaatagtccc actactttac caaggatttt
    11401 aacattgtcc aagaagattg gctccatcgt atcattttct ggctgtaaac gaaaacgtgt
    11461 tttttcttta tagaatcgtt tacaagtagc ttcattatca tcgttcattg caataacgat
    11521 atcaccattt ttagcggtgg attgtttacg cacgattact tggtcaccat taaagatccc
    11581 tgctttaatc atactggttc cacgaatggt aagcataaac aaatcattat tatcttgaat
    11641 agaaggaggt atcgggaaaa actcagtagc attttcgact gctaaaattg gttgtccagc
    11701 cgtaacaacg ccaagcattg gaatttcttt ttgaatcggt tttacaccta aaatatcaag
    11761 tcccttggat gtgatctcaa gtgctcgagg cttagaaggg tctttttgta agaatccttg
    11821 ttcaattaag cgggagatgt gtccatggac tgttgaagtt gaagacaggc caacagcact
    11881 acaaatttca cgaacagtcg gtggatagcc atgatcttca acttgtttgt gaatataatt
    11941 taggacggcc atttgtttat tttttgctac ctttgccata ttgacacctc attatcatta
    12001 attgtgttaa gcttatcata gatagatgca tatttcaaac gtacgttcgc gatttgcatt
    12061 gattttataa aataagtaaa atcgacttta ttaaggagat gattataatg gctgaatcta
    12121 aagaacaaga tgctttattg aagcgaatta atgaacttgc tcataagaat aaagaagaag
    12181 gcttaactga agaagaaaca aaagaacgag atcgtttacg taaggagtac ctaaagaact
    12241 ttagagaagc aatgcgtagt aatattgaaa tgatgcggat ttttgataaa gaagggaaag
    12301 aagttactcc tgaaaaggtt cgtgaaatcc aacgtaaaaa aggacttcgt gacgattaac
    12361 agcgatttgc tcttttcaaa aattgctctt tcgtgtaaga tggataggta acgagcaaag
    12421 gaggaagtaa ttgtgggtat gacgatcatg ctaatgattc ttgcattatt agtcggtttg
    12481 gttatcggct tctttggtgc acgtaaatac atggaaaact acctccgcaa taatccaccg
    12541 atttcggaag agatgctgcg gacgatgatg cttcaaatgg ggcaaaaacc atcaagtcgt
    12601 aaattacatc aaatgatgca agcgatgaaa gcacaagcta aaaagtcgaa tcgtaaataa
    12661 tataaaagga tgtgataatt atcacatcct tttatattgg aaattaaaat tcatcattct
    12721 tcggctttgg aggaacaata tatttataat tgggatcaat ttgtctatct aattggtcaa
    12781 aagcgtcttg catttgcttt tctaaatcag tctgtacttc aggagtaagt cgttgctttc
    12841 gatcaatata aataggcttt ccaaatgcga tttggcgagg tttacgggta aatagctggc
    12901 caaattttag agggccctgg taaacagcag gaactaaggg gacatttgcc attttagcga
    12961 tcacggtggc cccgcctttt aatttagatg aatagcgtga tccgctaggg aaaataatgg
    13021 tcgataagtc agtcttcttt aaaattgtaa ccggcttttt aatagcagac ggacctggat
    13081 ttttccgatc aactggatag gcatttagtg cttttaagaa tttgctagca attggattct
    13141 taaaaagttc ttttttagcc atgaagctaa attttttggg ccatacggca agcgctagta
    13201 agacaggatc catccaagta cgatgaggtg caataataat ataattgcct tcagggatgt
    13261 tttcccgatt gtatatttta ggtcgtccgt taatcaaatt taaaaatgga ttaacgattt
    13321 taacgaggaa agtgtacaac atgtcaatct tccaatctat aacaaaatta agtttgcgtt
    13381 cctcagtatg acgaaaaaaa gtggatcttg caagtacaaa aataatggag gacataatgg
    13441 aaaacagaaa tattttaaaa aaggatgaaa gaattgatca gttatatagt caggatgtac
    13501 ggataatcca aaatccccat tattttgctt tttcattaga tgctgtcttg ttagcaaatt
    13561 tcgtgcgtcc taatcatcga cagaaattaa aaattgttga cttgtgcgct ggaaacgggg
    13621 cgatcggcat ttttctccac gataagcttg gcggaacatt tactgaagtt gaattacaac
    13681 cacagattgc ggatatggct gaacggacaa ttatgctaaa tgatttacaa gatcggtata
    13741 ccgtcattaa tgatgatatt gctaacgtta atgattatat ttctaaggat tcgattgata
    13801 ttgtcctttg taatcctcct tatttcccag ttacagccca aagccagaag aatccaaata
    13861 aagctttagc gattgctcgt cacgaaatag cgactgattt agtgacagtt attcaaaaaa
    13921 tgagtggctt attaaaaatg aatggtcatg ggtatcttgt gcatcgtcca gatcgtttag
    13981 gtgagatttt gcaagtgtgt caggaaaata gattagcacc taaaagaatt cagtttattc
    14041 atcctaaacc tgatcgtgat gcgaatattt tgttgcttga agtgattaag gatggtcggc
    14101 ctggcggagt aaaagtagta ccaccattga ttgttcatgg agcagataac gagtatactc
    14161 cagcggttca ggagttatta tatggcaagt gagaaatact atatttatgt attgtattgc
    14221 gcggataata gcttttattg tggttttacc aacaatgtta aacggcgctt tcatactcat
    14281 cagacttatc aaggggcaaa atatactcgt gtgaaaaagc gtcatccgct aaagcttatt
    14341 tattcagagg aatttgaatc aaagcatgat gccctgagtg cggaatatta ttttaaacat
    14401 caaacccgcc gccaaaaaga aaaattttta ctagaccatg gtgtcgattt attgaaacta
    14461 cggaggaatt aagatgaaga tttatatgta tggtgtttat caggatgaag ttccttacat
    14521 taaggaatgg caagaggaac atcctgaagt aactgtagac tcaacaacga aacttttaga
    14581 tgaaaataca gttaacttgt ctaaaggaag cgatggagta gtagcattcc agcaaaagcc
    14641 ttattcagac gaggccttac gtcaattagc acttaatggt attacaaaga tgtcattgcg
    14701 aaatgttggg gttgataatc ttaaccatga attagtacaa gaacttggtt ttcaaattac
    14761 caatgtaccg gtttattccc cagctgcgat tgctgaattt tcagttactc aagcacttaa
    14821 ccttttacgt cgaacaaaag aattttattt gaagttagca aaaggagatt ataactgggc
    14881 accgcatatt gctaaggaaa tgaataagca ggttgttggg atagttggaa caggaaacat
    14941 tggatctacg gcggctaaaa tctttgctgg ttttggtgca aaagtgatag catatagccg
    15001 tcaccaaaat aaggaactag agggaattgt tgaatacgtt agccttaatg aattatataa
    15061 acgggcaaca attatttcac tttatttacc tcatgttcca gcgacagata aaatgcttaa
    15121 tgaaaaaaca tttgcaatga tgcaggacgg ggtcttactg gttaacactg cacgtggacc
    15181 attagtcgat gaaaaggcat tgattgaagc attgaatagc ggtaaagtcg gaggagctgc
    15241 tctagacgta atgactggtg aaaccaagat ttttaaccag caaattaatt tccaagaagt
    15301 tgattatgac gaatttaaag atttagttga ccggccaaat gttttaatca cgccacatat
    15361 tgctttttat actgatcaag caatcaaaaa tatggttaag atgagtttgt ctgccaatct
    15421 agatttgatt aaaactggca cctcagataa actagttaaa tttcccgaaa tgtcaattta
    15481 agttagaaag aaaatagttg ctcatcagtg acgtaagaca tgaatacttc atatggagtt
    15541 cgatagccta gtg
//
