LOCUS       gnlProkkaGNEHDOCD_25   13521 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GNEHDOCD_25.
ACCESSION   gnlProkkaGNEHDOCD_25
VERSION     gnlProkkaGNEHDOCD_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:24:51
            Original ID  :: gnl|Prokka|GNEHDOCD_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1926
            Orig. end    :: 15447
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13521
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8521]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8521
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13521
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13521
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1122..2258
                     /locus_tag="ctg19_3"
                     /transl_table=11
                     /translation="MSTLMEQTSEKETKQLHNNHNDEEIEIDLMDLLRKVIGIRKKIYK
                     AAGIGLIIGVIVAISIPKQYTVEVTLSPEMGNNKGGGLSGLAASFLGSGVSMGDGTDAL
                     NASLSADIVSSTPFLLELSNMKVPVSGSEKISLSSYLDEESSPWWSYVIGFPGMVIGGV
                     KSLFIEDEDESIFSDKASQGTIELSKKESQKIESLKKKIVASVDKKTSMTSVAATFQDS
                     KVAAVVADSVVKKLQEYIIDYRTSKSKEDCIYLEKLFKERQQEYYVAQKKYADYMDSHD
                     NIILQSVRTEQERLQNDMSLAYQVYSQVASQLQIARAKVQEEKPVFAVVEPAVVPLEPS
                     GTSRKVCVLAFIFLSVCIVISWNLFGKDFLNKFKEVCA"
     CDS             2278..3690
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 294.9; E-value:
                     1.9e-89)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="Bac_transf (E-value: 1.1e-68, bitscore:
                     222.5, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSTTSQINKFIEFVAVLGDLIILNLVLFFLLFFWEEVFVSLPFS
                     CRVSWMMTSLSLCYLACSGSRGRVWDSRGIRPDQLVLRVLKNIIAFSIFWACIMTFSGI
                     SIYSPLFFVAYFSFLFVILSIYRIIIRHFLIVYCAKGKHRRYAVFIGGGNNMQVLYEEM
                     ESSLASSLYEVVGYFDIKPNEAFSSQCSYLGNPDGFSDFMSVHPGIKHVFCSLSMEEGR
                     YNFSIMNHCENHLLYFHGVPNVCKGFPRRIWHSMVGNMPILNLRYEPLGKMENRILKRI
                     FDIVISGLFLVTIFPFVYLIVGSIIKLTSPGPVFFKQMRTGLNGVDFVCYKFRSMKVND
                     EADSKQATADDPRKTRFGDFLRRSNIDELPQFINVFKGDMSVVGPRPHMLAHTEIYARL
                     IDKYMVRHFIKPGVTGWAQTHGFRGETRELSQMEERVKADIWYMEHWTMLLDIYIIYKT
                     VANVIVGEKNAY"
     CDS             3752..4879
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MNHYDFLIVGAGLFGSVFAYKAKLQGKKCLVIDRRSHLGGNIYCE
                     NIEGINVHKYGAHIFHTSNKVVWDFVNSIVEFNRYTNSPIASYKGKLYNLPFNMNTFYQ
                     MWGITTPAEARAKIEEQKAEAIALMKEQGVIEPRNLEEQAQLLIGKDIYELLIKGYTEK
                     QWGRKCSDLPAFIIKRLPVRFIFDNNYFNDKYQGIPIGGYNVLIERLLEGIDTKLNYDF
                     FAHRNELEEISDRIVFTGAIDEFYRYRFGKLEYRTVNFETELLNMSNYQGNAVINYTEK
                     EIPYTRVIEHKHFEMFGADIEACSKTVISKEYSSEWKEGSEPYYPVNDEKNNSLYLKYK
                     KLADQDNNVIFGGRLAEYRYYDMHQIVTKALSHFK"
     CDS             5001..6284
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.1;
                     E-value: 1.8e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-13,
                     bitscore: 43.7, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 8.7e-118, bitscore:
                     384.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2e-61, bitscore:
                     199.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADIIHPGHLNIIHEANKLGRVVVGVLTDSAIASYKRLPYLSFE
                     QRSLIVENLKGVDEVIPQTTLDYVPNLEKIRPNYVLHGDDWKEGVQQKTRQHVIDCISQ
                     WGGKVIDIPYTQGISSSLLNQHLKEIGTTPEVRMKRLRRLIAAKPIVRILESHSGLTGL
                     IAENACIEINNVKREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHGLNDALEVTTKPFI
                     YDGDTGGKLEHFVFTVRTLERLGVSAVIIEDKVGLKQNSLFGTDAIQTQDTIEGFTAKI
                     KAGKNAQITEDFMIIARCESLIAGKPMSDAIERCFAYVEAGVDGIMIHSKEKTGEDIKE
                     FCKKFRARYADIPIVVVPTTYNQFTEEELASWGINVVIYANHMLRASYPAMMNCAKSIL
                     THGRSKEASAEYCMPIKEILELIPSTHK"
     CDS             6294..7418
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 62.4;
                     E-value: 5.9e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_7"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.4e-20, bitscore:
                     64.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7e-21, bitscore:
                     66.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPKFFIDELDRYGIDYFAGVPDSLLKSICGYIADNMDARHNII
                     TANEGAAVALAAGYHLATGKVGVVYMQNSGEGNAINPLASLVDKEVYNIPILLLIGWRG
                     CPGVQDEPQHVKQGKVTTGLLNIMGVNYDVLSKEENKAAKQILKAVEAVKRNEVYALII
                     EKDTFNAYTLQNVERNNFTMSREEAIQTVVAALGEADTIISTTGMISRELFEYRTAMNQ
                     GHERDFLTVGAMGHASQIALGIALEKQDRKVWCFDGDGASIMHMGSMAIVANKAPQNYV
                     HVVFNNGAHDSVGGQPTVGLKIDIPAIAKAMGYKHVYNVDTKEGLQELIGEIKVQEGPI
                     FLQACVKQGNRKDLGRPTTTPIQNKEALMTFLRS"
     CDS             7430..8521
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="Fe-ADH (E-value: 5.1e-67, bitscore: 218.3,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIYQGIDYLNEALKGSTKVLLVCGSSFPYLGIKDKIEHIGTPF
                     MVFDQFTSNPLYEDICRGVDLFQITQCDTILAIGGGSSMDVAKCVKLYCQMSKDKPYLQ
                     QEYKDTGVKLIAIPTTAGSGSESTCYAVIYHDGKKQSVMHKSIIPDVVILEPKLLKTLP
                     VYQKKCTMLDALCQGIESWWSVNSTDESKRYSKIAVETIIKYWREYIFENTDFSAEQIM
                     LAANYAGRAICITQTTAAHAFSYKITSLYKLPHGHAVAVGLSEIWEYMLLNMNKCLEPR
                     GEEYLWGIFADISKAMGCLTLEQAVVKFRQILTEMEITNPVAINKTEEIEILSHSVNPV
                     RLKNNPVELCEFTIKSLYEIIIK"
     CDS             8597..9577
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MTQYINSLEEEMRSGFLVTRQSKHVWNIQIEMTLALLEVCKKYNL
                     RIWAISGTMLGAVRHKGFIPWDDDMDFFMFREDYDRLLEIASDEFKKPIFFQCAYTEKG
                     YYRGHAQMRYDNTAMILLYEGEIGVKFHQGIFIDIFVADGFPEDKEEREQLIEQRNCIL
                     NYLWGRNYPLRRFSSIPNLIKYISAKRKLGEKASWTDIELYSYMEQLHRNYSVNRNSRN
                     CCIQFTYLPRYVRNTEWFDETVWIPFERIELPVPLAYHEVLKHEYGDYMKPIKGASLHG
                     NLVVDVDESYEKYLSGLKMSFLKATYLFIKSGGGMVLRVFGLRKK"
     CDS             9602..11029
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_10"
                     /sec_met_domain="Polysacc_synt (E-value: 4.1e-39, bitscore:
                     126.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKAVNGVFWTSVERIGSQVLSLLVGIAVARILSPEDYGIIGMT
                     AIFLAVASTLLDSGFGSALIQNQNRTETDYSTCFYFNIVVGLFWYVVLFLAAPLIADFY
                     RTPLLESVCRVLGLVFVFNSLTISQTARLTVEFRFRELCFVTLGTQLLTGIVGFIMAFK
                     GYGVWALVFQQVGAAFLRVCLIEWITHWKPLPLFSKIAFCRMFSFGSKILCSGIINTVY
                     DNIYTLVIGRVFSPVEVGFYNRGNQFAQLPSQSLLSVVMKVVYPLMAEVQDDSEKLCRA
                     YQKFLRISVFILYPILIGLIVLAESFIYVLLGDKWLPCVPLMQILCFSYLFDPLTHINL
                     NILYVRGRTDLVLKLELIKKPIALIILFGMLPFGLWWLCAGRALYSFIAYCFNCFYTGK
                     FIRFGFRQQMYYSVPVIVKSALMGIICWRTALGFEEPWLKLMVGFLAGLLSYIGLNFIS
                     HDESFFDIKGIILKNGK"
     CDS             11044..12060
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.6e-27,
                     bitscore: 87.5, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKILSVVIPSYNMEEYLYRNVSSMMIGEILDDLEIIIVNDGSKD
                     RTSEIAHELQRKASQSIVVIDKENGHYGSCVNAALKIATGKYFRILDADDWMDSGEFVK
                     FVNILKCIDVDCIYTPFANVFFNKNRKEYCIADNAVWNKKIDLSHVSLPPSYFHMHSLT
                     YRTHLLHKISFVQEEKICYTDSEYVFYPLSHAKSLYCINVCPYQYYIGREGQSVSLDSL
                     SKNYAHFEKVLANISFYKPMELLPTYSSLRKYYIVTLLRYMLDIHLFSQKKDVQRDKLL
                     RDKIRAFGDDVNISEQIKDINLKGLHYINWWLDNTGVDKLKLKILVLLKKVQHTIVN"
     CDS             12062..13027
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_12"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.3e-27,
                     bitscore: 88.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKISVIIPVYKVEQFIERCAISLFEQTLDDIEYLFIDDCSPDNS
                     VEIIKNVLMRYETRKDSVRIISMQKNCGQAAVRRYGNSIARGDYIIHCDGDDWVDINMY
                     YKMYECAVNNKLDIVRCKFCRTDGKLMKECINIPSNIYCDAKKMISYLLRLSDLSSTCD
                     KLVRRELYQSVDFIYPVDNMCEDFAIVTQLFCRTDKIGYIDEVLYFYYQNKFSISHILD
                     NTHIDNKAQQISNNVKLIGKILKTKYPGGIFDKEIEVIKLMAKNAYRPIIRREGYYEKW
                     KTLYKEINSKIFFNEYITIKEKLSFIACYIGIYPLLTGRK"
ORIGIN
        1 atcgccaacg tgaggatctt actactgaag ttatccctgt tgacattaaa gccattatgg
       61 atggtacttc tcaaaatatc atcctagcga aaaacgacat tctttatatt cctagtatcc
      121 atgatttgga agatagaggt gatgttgtaa tccatggtga agtggccaaa ccagattcct
      181 atccttatgc tgacaacatg actcttgaag acttgatcat tcaggccgga ggcttgcgtg
      241 aagccgcttc tgtagttcgt gtggatgtat cccgtagaat caagaatccc cgtagtacag
      301 tggataacga tactattggt cagatctata cattctccct gaaagaaggc tttgtcgtcg
      361 acggcacacc gggtttcgta cttcaacctt atgatgaggt ttatgttcgt cgtagtccgg
      421 gttatcaggc tcagcagaat gtagccgttg aaggtgaaat cctgttcgga gggtcttacg
      481 ccatgactag tcgtgaagaa cgtctttcag atttgatcaa taaagcggga ggtgctacga
      541 attatgctta cttacgcggt gccaagttga ctcgtgtcgc tactgcaggt gagaagaaac
      601 gtatgggaga tgtgatccgt ttgatgagtc gacagctagg agaagctatg atggattctt
      661 tgggcgtccg tgtggaagat cattttacag tcggcattga tttggagaaa gctatagcta
      721 atcctggcag tgcatcagat ttggttcttc gtgaaggtga tgtggttttt attccgaaga
      781 atactaatac ggtcacgatc aatggtgctg tcatggttcc gaatacggtt tcttatatag
      841 aaggacagaa agttgattat tatttgaatc aggccggtgg ttattctgaa aatgcgaaga
      901 agagcaagaa gttcattgtt tatatgaatg gtcaggtaac taaggttaaa ggtagcggta
      961 agaaacagat cgaaccggga tgtgagataa ttgtgcctag taaggctaag aagaagacca
     1021 atatgggaaa tattttaagt tatgctacta cattcagtac tttgggtatg atggttgcct
     1081 ctattgctaa tttaatcaag aaataacgaa tacctttatt tatgtctact ttgatggaac
     1141 aaacatctga gaaggaaaca aaacagttgc ataataatca caatgatgag gagatcgaaa
     1201 ttgatttgat ggatcttctt cgtaaggtta taggtattcg taagaaaatc tataaagcgg
     1261 ccggtatcgg actgataatt ggtgttattg ttgcgataag tatccctaag cagtacacgg
     1321 ttgaagttac cctttctccg gaaatgggta ataacaaagg tggtggttta tccggtttgg
     1381 ctgcttcatt tttaggaagt ggagtttcta tgggagatgg aaccgatgcc ttgaatgctt
     1441 ccttatctgc agatatcgtc tcttctactc ccttcttgtt ggaactttct aatatgaaag
     1501 tacctgtatc agggagtgag aaaatctctt taagttctta tttagatgaa gaatcttctc
     1561 cctggtggag ttatgtaatc gggtttcctg gtatggtaat tggcggagta aagtctttgt
     1621 ttatcgaaga tgaggatgaa tctatttttt cggataaagc gagtcaaggt accattgaat
     1681 tatctaaaaa ggaatctcag aagattgaat cactaaagaa aaagattgtc gcttctgtgg
     1741 ataagaaaac ttcaatgact tccgttgctg caacttttca ggattctaaa gttgctgcag
     1801 tcgtagccga ttccgtggtt aagaaattgc aggaatacat catagattat cgtacttcca
     1861 aatctaaaga ggattgtatt tatttggaga aacttttcaa agaacgtcaa caagaatatt
     1921 atgtcgctca gaagaaatat gctgactata tggactctca tgacaatatc attttgcaga
     1981 gtgttcgtac cgaacaggaa cgtttgcaga atgatatgag ccttgcttac caggtataca
     2041 gccaggttgc cagtcagctt cagattgcca gagctaaagt tcaggaagag aagccagtgt
     2101 ttgctgttgt agaacctgct gttgtcccct tggaaccttc gggaaccagt aggaaagtat
     2161 gtgttttagc ttttattttc ctatcagttt gtattgttat ctcttggaat ctattcggaa
     2221 aagattttct gaataagttc aaagaagtat gtgcctaaaa tcaattttta atgtgatatg
     2281 gtatcaacca ccagtcaaat caataaattt atagaatttg tagcagttct gggagatctg
     2341 atcattctga acctggtatt gttctttctc cttttctttt gggaagaagt atttgtctct
     2401 ttaccttttt cttgcagggt ttcatggatg atgacttcgt taagtctctg ctatctggcc
     2461 tgttctggat cccgtgggag ggtgtgggat agtcggggaa ttcgccctga ccaacttgtg
     2521 ttgcgtgtgt tgaagaatat tatagctttt tccatctttt gggcatgtat catgactttt
     2581 agtggaatct ctatctattc tcctcttttc tttgttgcct atttctcttt cctctttgtt
     2641 attctaagca tttatcgcat tattatccgt catttcctga tagtctattg tgctaaaggc
     2701 aagcatagac gttatgctgt ttttataggt ggaggcaata atatgcaggt gttgtatgag
     2761 gagatggaga gttctttagc ctcttcccta tatgaggttg tgggttattt tgatataaaa
     2821 ccgaatgaag ccttttcctc ccaatgttcc tatctgggta atcccgacgg tttttcagac
     2881 tttatgtccg tacatccggg aatcaaacat gttttttgtt ctctgtcgat ggaggagggg
     2941 cgctataatt tttctattat gaatcattgt gaaaaccatt tgctttattt tcatggtgtt
     3001 cctaatgtat gtaaaggttt tcctcgtcgt atctggcaca gtatggttgg caatatgcct
     3061 atcttgaatc tgcgttatga gcctttgggt aaaatggaaa atcggatatt gaagcgaata
     3121 tttgatattg ttatctcagg tctttttctg gttactattt ttccttttgt ttatctcata
     3181 gtgggaagta ttataaaatt gacttctccc ggtcctgtat tctttaagca aatgcgtacg
     3241 ggtttgaatg gtgtggattt tgtgtgttat aaattccgtt cgatgaaagt gaatgatgaa
     3301 gccgacagta aacaggctac ggctgatgat ccccgtaaaa caagatttgg agatttcctc
     3361 cgtcgttcta atattgacga actccctcag tttatcaatg tctttaaggg tgatatgtcg
     3421 gtagttggtc cccgtccaca catgttagcc catacggaga tttatgcccg tttgattgat
     3481 aaatatatgg tgcggcactt tataaaacct ggagtgaccg gttgggctca aacgcatggt
     3541 tttcgtggtg aaacgaggga attatcacag atggaggaac gtgttaaggc tgatatctgg
     3601 tatatggagc actggacaat gctgcttgac atatatatca tttataagac tgtggcgaat
     3661 gtgattgtgg gggagaagaa tgcgtattag aagaggggat attaacgaat ttaaatgtat
     3721 ttcgtaatat agaaataaaa ttagaaatgt catgaatcat tacgatttct taatagtagg
     3781 tgccggactt tttggttccg tattcgccta taaagcaaaa ctacaaggta aaaagtgttt
     3841 agttattgat cgccgttctc atttgggtgg gaatatttat tgtgaaaaca tagaaggtat
     3901 taatgttcat aaatatggag cacacatttt tcatacttcc aataaagtag tgtgggattt
     3961 tgtaaattcc attgtggaat tcaatcgcta taccaattca ccgatagcta gctataaagg
     4021 aaagctgtat aatttacctt tcaatatgaa tactttctat cagatgtggg gaatcactac
     4081 tcctgctgaa gcaagggcaa agattgaaga acagaaggca gaggcgattg ctctcatgaa
     4141 agaacaaggt gttattgaac ctcgcaactt ggaagagcag gcacagttac ttatcggaaa
     4201 ggatatttat gaattgctga ttaagggtta tacagaaaaa cagtggggac gcaaatgtag
     4261 cgatcttccc gcattcatca tcaaacgact tcctgtacgt tttatttttg ataacaacta
     4321 ttttaacgat aaatatcagg gaattcctat cggtggatac aatgtactga tagagcgctt
     4381 gctggaaggt atagatacca aactaaacta tgatttcttt gctcaccgga atgagttgga
     4441 agaaatttca gataggatag tatttacagg agcaatagat gagttttata gatatagatt
     4501 cgggaagttg gaatatcgta cagtaaattt tgaaacggag ctattaaata tgtccaacta
     4561 tcagggtaat gcagtaatta attatacaga aaaagaaatt ccctatacac gtgtcattga
     4621 gcataagcat tttgaaatgt tcggggcgga cattgaggct tgttctaaaa ctgttatctc
     4681 gaaggaatac agttcagaat ggaaagaagg gagcgaacct tattatccag taaatgacga
     4741 aaagaataat tcgctttatc ttaaatataa gaaactggct gatcaggata acaatgtgat
     4801 ttttggaggt cgattggcag aatatagata ttatgatatg catcaaatag taacaaaagc
     4861 tttaagccat tttaaatgaa ggcatatgtt aatatatcta atttttgaag gtgtattttt
     4921 atgtgattaa atataaaaaa actgtctata tagtattata attcaataat atggataaga
     4981 taaaaactgt ttatgtcggt atgagtgctg acataattca cccggggcat ctcaacataa
     5041 ttcatgaggc aaataagctt ggtcgtgttg tggtaggggt attaacggat tcggcaatag
     5101 ctagttacaa gcggttgcct tatctgtcat ttgaacaacg ttcacttatt gttgagaatc
     5161 tgaaaggggt ggatgaagtc atacctcaga ctactcttga ttatgtaccg aatttggaga
     5221 aaatccgtcc aaattatgtt cttcacggtg atgattggaa agagggggtt cagcagaaga
     5281 cgcgtcagca tgttatcgat tgcatttcac aatggggagg taaggttata gatattcctt
     5341 atactcaagg tatttcttct tcattgctta accaacatct gaaagagata ggtacaaccc
     5401 ctgaagtccg aatgaaaaga cttcgccggc tgattgctgc taagcctatt gtacgtattc
     5461 ttgaaagtca ttcaggactt actggtctta ttgcggaaaa tgcttgcatt gaaattaata
     5521 atgtgaagcg tgagttcgac ggtatgtggg catcttcatt gaccgattct acctcaaagg
     5581 gtaaaccgga tatagaggct gtcgacttga cgacacggct tcatggtctt aacgatgctc
     5641 tcgaagtaac tacaaaaccg tttatttatg atggtgatac tggtggaaaa ttagagcatt
     5701 ttgttttcac tgttcgcact ttagaacgtc tgggagtttc tgctgttatc attgaggata
     5761 aagtgggatt aaagcaaaat tcactattcg gtacagacgc tattcagaca caggatacta
     5821 tcgaaggatt tacagcaaag attaaggcgg gcaaaaatgc tcagattact gaagacttta
     5881 tgattatagc acgttgtgaa tcgcttattg caggtaagcc aatgtctgat gctattgagc
     5941 gttgctttgc ttatgtggag gctggtgttg atggtatcat gattcattca aaggaaaaaa
     6001 caggtgagga tatcaaggaa ttctgtaaaa aatttcgtgc aagatatgcg gatataccca
     6061 ttgtggttgt tccgacaacc tataatcagt ttacagagga ggagttggct tcatggggaa
     6121 taaatgtggt aatatatgca aatcacatgc ttcgtgcatc ttatccagca atgatgaatt
     6181 gtgccaagtc tatcttgaca catggtcgtt caaaagaggc ttctgcagaa tactgcatgc
     6241 ctatcaaaga gattcttgaa ctcatcccta gtacacataa ataaaataat ataatgatta
     6301 gtccgaaatt ttttatagac gaattggata ggtatggtat tgactatttt gcaggtgtac
     6361 cggattcgct actgaagagt atctgtggat acatagccga caatatggat gctaggcaca
     6421 acattataac tgctaatgaa ggtgctgctg ttgctcttgc ggctggttat catttagcca
     6481 caggaaaggt aggtgttgta tacatgcaga actctggtga gggaaatgcc ataaatccat
     6541 tggcttcact agtagataag gaagtctata atataccgat tcttcttctg attggttggc
     6601 gtggttgtcc tggggtgcaa gatgaaccac aacatgtaaa acagggcaag gtgacaaccg
     6661 gattgcttaa tattatggga gtgaactatg atgtgctttc aaaagaagaa aacaaggctg
     6721 caaagcaaat attaaaagct gtagaggcgg ttaaacggaa tgaggtctat gcccttatca
     6781 ttgaaaaaga cacctttaat gcctatactc ttcaaaatgt agagagaaat aattttacga
     6841 tgtctcgtga agaggctatt caaacagttg tagcagcact tggtgaagct gatactatta
     6901 tatctactac aggtatgata agtcgtgaac tcttcgagta ccgtactgct atgaatcaag
     6961 gacatgagcg cgattttttg acagtagggg ctatgggaca tgcctctcaa atagctttag
     7021 gcatagcttt agagaagcaa gatcgcaaag tgtggtgttt tgatggtgat ggagcttcta
     7081 ttatgcatat gggtagtatg gctattgtgg ctaataaagc gcctcagaac tatgttcatg
     7141 tagtttttaa taatggtgct cacgactcgg tcggaggtca gcctactgta ggtttgaaga
     7201 ttgatatacc tgctatagct aaagctatgg ggtataaaca tgtttataat gtcgatacaa
     7261 aggaggggct acaagaattg attggtgaaa tcaaagtcca agaaggacca attttcttgc
     7321 aggcatgtgt caagcagggc aatcgcaagg atttaggtcg tcccactact acacctattc
     7381 agaataagga agctctgatg acttttttaa ggagttagat ttatataata tgcaaataat
     7441 atatcaagga attgattatc ttaatgaagc tctcaaaggt tctaccaagg tgctattagt
     7501 ttgtggtagt agctttcctt atcttggtat taaggataag atagaacata ttggtactcc
     7561 cttcatggtg tttgatcagt ttacttctaa tcctctttat gaagatatct gtaggggggt
     7621 agaccttttc cagattactc aatgcgacac aattcttgct attggtggtg gtagctcaat
     7681 ggacgtggct aaatgtgtaa agctatattg tcaaatgtca aaagataagc cctatttgca
     7741 gcaagagtac aaagatactg gcgtgaaact gattgccatt cctactacgg caggttcagg
     7801 gtctgaatct acctgctatg ccgttattta tcatgatggt aagaaacaga gcgtgatgca
     7861 caaaagtatt attcctgatg tcgtcattct tgaaccaaag ttgctcaaga ctcttcccgt
     7921 ttatcagaag aaatgtacta tgcttgatgc tctttgtcaa ggtattgaat cttggtggtc
     7981 tgtgaactcc actgacgaga gcaagcgtta ttccaagata gctgttgaga caatcataaa
     8041 gtattggcgt gagtatattt ttgaaaatac agacttttca gctgaacaga tcatgttggc
     8101 tgctaactat gctggtcgtg ccatttgcat aactcaaact acggccgcac atgctttcag
     8161 ttataagatt acttctctat ataaacttcc tcatggtcat gctgtggcag taggactttc
     8221 agaaatatgg gaatatatgt tgttgaacat gaacaaatgt ttagaacctc gcggtgaaga
     8281 atatctttgg ggcatctttg ctgacatttc taaagctatg gggtgcttaa ctttggagca
     8341 agctgttgtc aagtttcgcc aaatattgac agaaatggaa atcacaaacc cggttgctat
     8401 taataagaca gaggagattg aaattctttc ccattcagtt aatcccgtta ggctgaagaa
     8461 taatcctgtg gaactttgcg aatttactat taagtctctt tatgagatta ttattaaata
     8521 gatatctatg agtttattca atgaataagg agtattaagt gatgatctaa aataatagcc
     8581 gtttacttac acttttatga cacaatatat aaattcgctt gaagaagaga tgcggagtgg
     8641 ttttttggtt acgcgtcaaa gcaaacacgt atggaatata cagatagaaa tgacattggc
     8701 acttcttgag gtatgtaaaa aatataatct tcgtatatgg gcaataagtg gaacgatgct
     8761 gggagctgtg cggcataaag gatttattcc atgggatgat gatatggatt tttttatgtt
     8821 cagagaagat tatgaccgtt tattagaaat agcttcggat gaatttaaaa aacctatatt
     8881 ctttcagtgt gcttatactg aaaaaggata ttatagaggg catgctcaga tgcgttatga
     8941 caatacagct atgatattgt tatatgaagg agaaatcggc gttaaatttc atcaggggat
     9001 atttatagat atatttgtag ctgacggatt tcctgaagat aaagaagaaa gagaacaact
     9061 tatagaacag agaaactgca ttctaaatta tttatgggga agaaattatc ctctgagacg
     9121 gttctcttcc ataccgaatt tgataaaata catttctgct aaacgaaagt tgggggaaaa
     9181 ggcttcgtgg actgatattg aactttattc ttacatggaa caacttcatc gtaactattc
     9241 tgttaacaga aattcaagga attgttgtat tcaatttact tatttgccta gatatgtgag
     9301 aaatacagaa tggttcgatg aaacagtctg gataccattt gagagaatag aattgcctgt
     9361 tcctttggca tatcatgaag tgttgaagca tgaatatggt gattatatga aaccgatcaa
     9421 gggggcgagt cttcatggta atttggtggt agatgtagat gaatcttacg agaaatatct
     9481 ttcaggtctg aagatgtctt ttctaaaagc tacatatttg tttataaagt cagggggcgg
     9541 gatggtgctt cgtgtatttg gtttgagaaa aaagtaaatt taggatagcg gcgactacgt
     9601 tatgaaagat aaagctgtca acggtgtttt ttggacttcg gtggaaagaa ttggtagtca
     9661 ggtgcttagt cttcttgtag gaatagcagt tgcgaggatt ctatctccag aagattatgg
     9721 tataatagga atgactgcca ttttcttagc agtagcttct actcttcttg acagcggatt
     9781 tggtagcgca ctaatacaaa atcaaaatag aacagaaact gattattcta cttgctttta
     9841 ttttaatata gttgtaggtc tgttttggta tgtagtattg tttttagcag ctccgctaat
     9901 agcagacttt tatcgtacgc cattgctgga atcggtttgc agagttctag gtttggtttt
     9961 tgtattcaat tcacttacaa tttcgcagac ggcacggctt accgtagaat ttagatttcg
    10021 ggaactgtgt ttcgttacat taggtacgca gttgttaacg ggaattgttg gtttcattat
    10081 ggcatttaaa ggttatggag tatgggcgtt ggtgtttcag caagtaggcg cagctttttt
    10141 aagagtatgt ctgatagaat ggattacaca ttggaaaccg ttacccttgt tttccaagat
    10201 tgcattttgt agaatgtttt catttggttc taaaatacta tgttcaggca ttataaatac
    10261 tgtttatgac aatatctata cattagtgat agggcgtgtc ttttcacctg tagaagttgg
    10321 attctataat agaggaaatc agtttgcaca attaccatct caaagtttgc tatctgttgt
    10381 tatgaaagtc gtttatccat tgatggcaga agtgcaagat gattcggaaa aactttgtag
    10441 agcttatcag aaatttttgc gtatttcggt tttcattctt tatcctattc ttattgggtt
    10501 aatagtctta gcagagtctt ttatttatgt attgctaggc gataaatggt tgccttgtgt
    10561 tcccttgatg caaatattat gttttagcta cttgtttgac ccacttacac atataaatct
    10621 taatattttg tatgtaagag gacggactga tttagtactt aaactagaac ttataaagaa
    10681 accgatagca ttgattattt tgtttggaat gctaccattc gggttatggt ggctgtgtgc
    10741 aggacgtgct ttgtacagtt ttatagcgta ctgctttaat tgtttttata ctggaaagtt
    10801 tattagattt ggttttaggc aacagatgta ctatagtgta cctgtgattg taaaatctgc
    10861 tttgatgggg attatttgtt ggagaacagc attaggcttt gaagaaccat ggttaaagtt
    10921 gatggtagga tttttggcag gattgctttc ttatatagga ctgaatttta taagtcatga
    10981 tgaaagtttt tttgatataa aagggataat attgaaaaat gggaaatgat aaataatata
    11041 ataatgaaca aaatattatc tgtagttatt ccttcgtata atatggagga gtatttgtac
    11101 cgaaatgtga gtagcatgat gattggggaa atattagatg accttgaaat cattattgtt
    11161 aatgacggaa gtaaggatag aacgtctgaa atagcacatg aacttcaaag aaaagcttct
    11221 caaagtattg ttgttattga taaggaaaac ggtcattatg gttcatgtgt aaatgcagcg
    11281 ttgaagatag caacaggcaa atattttcga attttggatg cggatgactg gatggatagc
    11341 ggtgaatttg taaaatttgt aaatatattg aagtgtattg atgtagactg tatctataca
    11401 ccttttgcga atgttttttt taataaaaat agaaaggaat attgtattgc tgataatgca
    11461 gtgtggaata aaaagataga tctgagtcat gtctcattgc ccccttctta ttttcacatg
    11521 cactcattga cttatcggac tcatttgtta cataaaataa gttttgtgca ggaagaaaag
    11581 atttgttata cggattcaga gtatgttttt tatcctttgt ctcatgcaaa atcgttatac
    11641 tgtattaatg tttgccctta tcagtattat ataggtcgcg aaggacaatc tgtatcattg
    11701 gattctttga gtaaaaacta tgctcatttt gagaaagtat tggcaaatat cagtttttat
    11761 aagcctatgg aattgttacc gacatattca tcacttagaa aatattatat tgtgacgctg
    11821 ctacgttata tgcttgatat tcatcttttt tcacagaaaa aggatgttca gagagacaag
    11881 ctattaagag acaaaataag ggcttttggt gatgacgtta acattagtga acaaattaaa
    11941 gacatcaatc ttaaggggtt gcattatatt aattggtggt tggataatac aggtgttgat
    12001 aaattaaaac ttaaaattct tgtcttatta aaaaaagtac aacatacaat agttaattga
    12061 aatgcctaaa attagcgtaa taataccggt gtataaagta gaacaattta tagaaaggtg
    12121 tgcaattagt cttttcgaac aaactttaga cgatattgaa tatcttttca tagatgattg
    12181 ttcacctgat aattcagtgg agattattaa aaatgttttg atgcgatatg aaacaagaaa
    12241 agattcggtt cgtattatat ctatgcaaaa gaattgtgga caagctgctg tgcgtagata
    12301 tggcaatagt atagctcgtg gtgattatat aattcattgt gacggagacg attgggtgga
    12361 tattaatatg tactacaaaa tgtacgagtg tgctgtcaat aataagttag atattgtcag
    12421 gtgtaaattt tgtagaacag atggaaagtt aatgaaagaa tgtattaata tcccaagtaa
    12481 tatatattgt gatgcaaaaa aaatgatttc ctacttgtta aggttatctg atttatcttc
    12541 aacttgcgat aaattggtaa gacgggaact ttatcaatca gtagatttta tatatcctgt
    12601 tgataatatg tgtgaagatt tcgcaattgt aactcaattg ttttgtcgta ctgataaaat
    12661 tggatatata gatgaagttc tctattttta ttatcaaaat aaattttcaa taagtcatat
    12721 attggataat actcatatag ataataaggc acaacaaata agcaataatg taaaactgat
    12781 aggaaaaatt ttgaaaacaa aatatccagg tggaattttc gataaagaaa ttgaagtaat
    12841 taaattgatg gcaaaaaatg cctatagacc tattataaga agagaagggt attatgaaaa
    12901 gtggaaaaca ttatataagg aaataaattc gaaaatattt ttcaatgaat atataacaat
    12961 aaaagaaaaa ttgtcattta tagcttgcta tatcgggata tatcctttgt tgactgggcg
    13021 taaatagtaa atatgggaaa tatagaaaat tgtatatatt taattacttt gtttttgttt
    13081 gagatattat tatttcttta tgtatggcag aagtttgata gatctatttt ttctccatca
    13141 atatatacta tcggtgtttt aggatttgga acattgctga atatttggtg tgttgattat
    13201 tgggatatta gttttcatcc acgtacattt ggaattatag ctttaggatt atgcatgatg
    13261 gttattgctg aaaaaaatgc ttatataaaa agacgtaatg atagtgaata taagatgttt
    13321 tatatttctt tacctcctat gttagttatc tctgtggctg catattgcat tgtagcaaca
    13381 tttttgtatt ttaatgaaat acgtagattg gggttagcgc aatctttggc ggtttcagaa
    13441 gcgataggta atataaagga aaattttgag gaatttgaag aattatttaa cccatttatt
    13501 cggcaaggat ataaaatagt t
//
