LOCUS       gnlProkkaIOGININI_67   17144 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IOGININI_67.
ACCESSION   gnlProkkaIOGININI_67
VERSION     gnlProkkaIOGININI_67
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:07:24
            Original ID  :: gnl|Prokka|IOGININI_67
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17144
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..159
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MTNGTDKLNLKDREWTCPNCHEHHIRDWNAAKNILAKGLDKLEKP
                     KNLAKAK"
     protocluster    1..17144
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4241:12144]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4242..12144
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..17144
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17144
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             517..786
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="MMDYLVIKSIIWIFFITSAILEVNYKKKYGELDKRARKQATLGIF
                     LIVTTIFDEGYENKILYTIVSIALLVYIVLVMYRLVMAIKDRKK"
     CDS             807..1148
                     /locus_tag="ctg53_3"
                     /transl_table=11
                     /translation="MKAIYRGRKVDVWQVSRDNIQPDWVKYAFEHNGLRWLHGSGNKVR
                     IYWPAVTRAKKGIIRTILNGISASLVSINGGSASMYDIGFEGDVIDFTNSKVVTAEKFA
                     KKYRIVSED"
     CDS             1259..1909
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 130.7; E-value: 1e-39)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MIKAAIFDLDGLLVDTEIVSLKIYQELLSEYGYSFTKEEYAKHYS
                     GKTEKENIKRFIDTYNLSVSYQEYLDEVLNIERKLISQGVELKVGVKSLLVYLKENNYK
                     VALATSSTKDRAISILKGHDILSYFDEFVFSEDVTLSKPNPEVFLKACEKINVSTNEAI
                     VLEDSENGIMAAYNAHIPVICIPDMKRPAKEYLEKTIAVCKTLNDVIDYLKTK"
     CDS             2963..3145
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MGVKAPVKISAWTNFKTLFNEPSGWWTTYASGYIGDYLDFTNRKI
                     IPERKFKKKYKIVNK"
     CDS             complement(3184..3447)
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MNSFSNNINFSKISVSLITLLLLIWTLVDGNLIHLGILAFSSLVT
                     TMLHFHYFEATDDKHPLNRIDFGLQLLFIFISIIKFFLISGR"
     CDS             3679..3852
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MNNNFIQVDKKELAHIIGGRNSYDYIDSGQFGYDIGCTIANTKFF
                     KRLRHSNQNICS"
     CDS             3976..4233
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MLKKLWNIWLDGGLIRGRKRYVIIPIIFAIFLPLSMWLSDNEGMS
                     YLDYIQMPKWIIFAVFCLVGGSTLLYLLDTAMKVNKHMKG"
     CDS             4242..4481
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-15,
                     bitscore: 50.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEFTVLTECELAKVDGGYTPKNCAIAVGGGMLSGAIRGGMAGTV
                     FGVGTGNLAGAFAGAHIGLVAGGLACIGGYLGSH"
     CDS             4498..4677
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MIFWVTVIVVYSTFISIYTSKKEDGHYKLFDEKAIKKNKKISYKK
                     AWILNFIYWFYGFY"
     CDS             4698..4907
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_11"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.7e-11,
                     bitscore: 35.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYEKLNNEEFSKILGGNGINWGAVAGSCASGAVIGAAFGNPLTG
                     CVANSAFSFSWQAFKNRPRPKKIA"
     CDS             5007..5171
                     /locus_tag="ctg53_12"
                     /transl_table=11
                     /translation="MTFWVTLAVPYIIFISIYTSKKEDGHYRLFDEKVIKKNKKISYVV
                     AIVLRISSK"
     CDS             5268..5384
                     /locus_tag="ctg53_13"
                     /transl_table=11
                     /translation="MKFEVLTEKKLQKIAGGATKKGGFKRWQCIFTFFGVCK"
     CDS             5384..6673
                     /locus_tag="ctg53_14"
                     /transl_table=11
                     /translation="MVNLNSTSGYIVATLILFINTFCRYSFFYLLTPTRKSKKYNLLFI
                     LLTFPVILLINGVGDIIGFFAPFIEIFIFYIVYRQLTLDYRLCGRLLMLDLFSYITFGA
                     SALFFTLFTNYYTMVSVIILDVSLNIFEYIILTKTTIIEKLDDEYGLLYFYLILYIWIS
                     SMVIYYLTTYVFNIDAVSYIIAMVVVVSQLFFSLFVYSINKKIRQDKLSLQQINDLKIY
                     TQQLESSQRGLRKFKHDYQNMLLSLKLSAKKSHDKELIDKLAEYSSKTLEDKVLWQFND
                     VDNVKDELLKSLFISKLNRIFQNNIQYSFECRIVIENLSNKYNSFDIVRILGIVYDNAI
                     EESLEFGDEAKIDTMIYQENGELEIEIRNRYRDTDLTIQDIKKSGFTTKKNHDGLGLAN
                     IEELSQSYNDIFINYQIKDGWFTFLMVMSI"
     CDS             6687..7481
                     /locus_tag="ctg53_15"
                     /transl_table=11
                     /translation="MEEYGIIICDDEKDQVRRIHDLVKYAIWSLEDSADSKDKEFKITL
                     EANSYIEVADYLEDNKVDSGVYFLDIELSRDKADRDGIDLAEFIRQKDPNAQIIFITAY
                     ENLAAMTYRRRTGALDFITKNDSDEVIQKRLNETLSLATRRIRESHAIKKMTFSYKMGR
                     RIINENINDILYIITTPKSHRLKIVTVNGMGEFTGDIKKLEAENDFLEKISQSCLANPS
                     NIVEINQSTRVISFKDGYKETFPRRSKAKMKSLIERYNLRTV"
     CDS             7518..7757
                     /locus_tag="ctg53_16"
                     /transl_table=11
                     /translation="MVETGIIILLVVGFMVISRLKVNFTKNSRYAGFLLLILLDLNGLM
                     RTSMLTMRGLILLGTLMVFVVMLIKEIRQNRKYN"
     CDS             complement(8208..8387)
                     /locus_tag="ctg53_17"
                     /transl_table=11
                     /translation="MDWVSQFLMKKTDRILMYCIGIGQILMGLINMMLGSGVIYSIFLM
                     SVGIVIIVTSKPRK"
     CDS             complement(8565..8783)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_18"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7e-15, bitscore:
                     48.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKEFTVLTECELAKVDGGKGSKGSSYVAGFASAAIAGTGLGGAI
                     CGVPCAMIGAHYAPIGWTIVTGATGGF"
     CDS             9255..9401
                     /locus_tag="ctg53_19"
                     /transl_table=11
                     /translation="MKVYNEENLAEIIGGRSIEGKIWYGYGYQLGMTARWNLRHPYFQL
                     PYH"
     CDS             9419..9616
                     /locus_tag="ctg53_20"
                     /transl_table=11
                     /translation="MKINKKFYKNYTFYIGLVMLSIAIGSIFFDKGYFLFTIIDIFFAY
                     LGIKYIYQSLVVTKLCERGH"
     CDS             9618..9788
                     /locus_tag="ctg53_21"
                     /transl_table=11
                     /translation="MNKKLNSIDEKDLVKIVGGGSPWSNLIVQGAVAVFKSGYRHRNDI
                     KAGFSAGFYGK"
     CDS             9985..12144
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 316.9; E-value:
                     4.4e-96)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_22"
                     /sec_met_domain="Peptidase_C39 (E-value: 8e-46, bitscore:
                     147.9, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1083.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHKYKKYYIPQVDESDCGVASLAMILKHYGSSVSLAYLRKIAKT
                     TMEGTTALGIVKTAQELGLETQAVKADMSLFEMKDITYPFIAHVIKNGTLLHYYVVLKA
                     TSKYILIADPAQEVGITKMSYERFEEEWTGVTLFIAPGIEYKPVKEDRKKLWSLFTKLF
                     KQKQLVLNIVLAALLITIISILGSYFLQAVIDTYIPNGMRNTMAIIALGLLVIYIFNSI
                     FTYARDFLLAVLGQRLSIEIILSYIRHIFELPMEFFATRKTGEIVSRFNDASKIIDALA
                     STVISIFLDVSIVVIMGIILAIQNLKLLGITLISLPIYAVIILTFTKAFEKLNNKQMES
                     NAVLSSSIIEDIQGIETIKALNSEQTRYRRIDGQFVDYLKKSLAYLKTDSLQQALKLCI
                     QQSLNVVVLWLGANLVINNQLSIGQLMTFNALLSYFVNPLQNIINLQPKLQSARVAHNR
                     LNEVYLVESEFKDKKVIHDVQQLQGDIEFEDVDYRYGYGENVLDKINLTIKQREKLTIV
                     GMSGSGKSTLVKLLVNFFEPTSGILKFNNHSSNEIDKHILRSYINYVPQNPYIFAGTIE
                     DNLKLGNRINVTDEDIFNACKIAMIAEDIAKMPLQLRTELDENANTLSGGQKQRITIAR
                     ALLSPAQVLIFDESTSGLDAITEKRLIDNLMQLKDKTIIFIAHRLSIAKRTDNILVLDN
                     GKIVEQGRHDELLAQEGYYYNLVNS"
     CDS             12155..13303
                     /locus_tag="ctg53_23"
                     /transl_table=11
                     /translation="MEDKFLESSEFYSTRFRNFSTMIIIPTAILLLLVIMFGFFGKKEI
                     TIKGVGTLEAVGTNPVIQATVNSPIEKNYLEEGKYVKKGDTLLVYNNVNIRDKEKLYNY
                     QRETLNQQLEALNLLKQGIQTNQDTFGSDDEFGYHNELDSYLEQRNTYLTENTMIQEKA
                     KNDKAKQSSISSELKKQGELSSSIPDFDSSKYDVEINNQKLQELQSSKLNSINQEITKV
                     KQNLQEIDTNISDNNNVNKEYKVTAIKNGILHINNNYKGSRYVSAGTNLAQILPVLKTQ
                     KTLKINAYISTADISSIKVGQNIKFKVIRNVPKPIILTGKIYKIGVSPVTVEKNDYYQV
                     EAKVNINDSNKDLLKYGMQGQTTVITGKTTFFEYYKNKLLDK"
     CDS             13538..14839
                     /locus_tag="ctg53_24"
                     /transl_table=11
                     /translation="MNLELLIPISLSIGIVLLFNTYQFKRMNIVSIINICIAFILSLYN
                     GIYYHERYLLLLLVLVIEVIVINKKIITVDIAVLLIIYLFFVLDYNILLFLTHLVGTIA
                     GKITKFDEFLIGVLIIVSLIVVYLLLKNNRNKINKIIETIKHNTILLKTIISVVLILLF
                     SESLILFLVDIYGIRELVQGFLIAFLGIVTGIILLILDYYIVMYQEKVQYKLQREKYIQ
                     QEKYLSALEKSYQDLRKARHDYQNTLLAIQGAINEKNILEAENYLKEILKQTNNDTKNE
                     AKILFNLNKIKLSGIRNLLAVKIKKMQEFGIKYTMEVIDDIDNLPGDIVSIVRIIGILV
                     DNAIEASQNQDNPQINLALIKYNSKAYSFSIVNKINKKVELNKIIERGYTTKENHTGLG
                     LDNVLQLVEKSENFTLEINQSNNTIEFDFMMEGM"
     CDS             14840..15598
                     /locus_tag="ctg53_25"
                     /transl_table=11
                     /translation="MLKVLILEDNNLQRKTISQIVQNRIMINNTDKSYDMEITISTDNP
                     VDAINYVENHREEMVLAFLDIDLKNKQINGLDIAEHIRQYLRFAEIVFVTTHQELMPLT
                     LRKKVAPLDFIDKDNNMTDQIRECVDIAYEHYQKEISGPSKSTLTYEIMNGIYKQILIE
                     KIYSFESIKGNNRHIKLIAEDAVATIIGNLRDIEQKNEEFFRCNRNTVINLINIEQIDL
                     NSKIIKLKNSSIYNISTRKIKDIKKILKSR"
     CDS             complement(16002..16163)
                     /locus_tag="ctg53_26"
                     /transl_table=11
                     /translation="MKYDKLKSILIIITFLLIIVDIFTRGQVNGIVPLFIILIAAKIRH
                     AKYSKDKN"
     CDS             complement(16193..16342)
                     /locus_tag="ctg53_27"
                     /transl_table=11
                     /translation="MNNLQKFEIISDTTLSHVNGGYNRLAGRIGHYTGKAALWGIAVAG
                     LFLI"
     CDS             complement(16370..16504)
                     /locus_tag="ctg53_28"
                     /transl_table=11
                     /translation="MDNCNNFTSLNNTELQGIIGGKHGLGYHIVDAVVSFGEGFLNAI"
ORIGIN
        1 ggaacaaatg gaactgataa gttgaatctc aaggatagag aatggacttg tcctaattgt
       61 catgaacacc atattagaga ttggaatgca gctaaaaata ttctagctaa aggattagat
      121 aagttagaaa aaccaaaaaa cttagctaaa gctaagtaaa gggtgcgttt ggcagcttgc
      181 gccacccgta tattattgta tacaaagtgc tgtggtaaat tgatgtgtaa gacgtaagta
      241 tctttttttg gatatttatg ctgtatttta cccacggaag agtgtgttag tagagccgaa
      301 aggcttgaac actcacaagc cccatgtctt tagactgggg tgagttgaca tagttgggaa
      361 tagtggcaag gcagcgatgt ttttgtcgct atttttttaa cgtacatgga tatgttgtta
      421 accaaataag cgggaaagag tgttaattaa gaaaatatag aattgaattt aattaaaata
      481 gtataataat ggcaaaaata gagaatagat ggtggaatga tggattattt agttattaaa
      541 tcaattattt ggatattttt tataacatca gcaattttgg aagttaatta taagaaaaaa
      601 tatggtgaat tagataaacg agctagaaaa caagcaacat taggaatatt tctaatagta
      661 actacaatat ttgatgaagg ctatgaaaat aaaatactat atacgatagt atcaatagca
      721 ttgttggtat atatagtctt agtgatgtat agattagtta tggctattaa ggataggaaa
      781 aaataataag aaaggtgata aagcaaatga aagcaatcta tagaggtaga aaagtagatg
      841 tttggcaagt gagtagagat aatatccagc ctgattgggt aaaatatgct tttgagcata
      901 atggattacg atggctgcat ggtagtggta ataaagtcag aatttattgg ccggcagtta
      961 ctagggcaaa aaaaggaata atacgaacta ttttgaatgg tatttcagct tctcttgtta
     1021 gtataaatgg tggcagcgcg tcgatgtatg atattggctt tgagggagat gttatcgact
     1081 ttaccaattc taaggttgtt acagccgaaa agttcgctaa gaaatatcgg atagtgtctg
     1141 aagattgagg taaaggtatt aaattgtcta tgacaagata atcaactttt atgtcaaaat
     1201 aagattgaat aattatatga tataataaat atgtattacg aaaggtggtt gatttattgt
     1261 gattaaagcg gctatatttg atcttgatgg attgctagta gatacagaaa ttgtatcttt
     1321 aaaaatatat caggaattat tatctgaata tggatatagt tttactaaag aagaatatgc
     1381 aaaacattat agtggtaaaa cagaaaaaga aaatattaaa cgttttatag atacgtataa
     1441 cttatcggta tcttatcagg aatatttaga tgaagttttg aatattgaac gcaaacttat
     1501 ttcacaaggt gtggaattaa aagtaggggt aaaatctcta cttgtgtatc taaaagagaa
     1561 taattataaa gtagctttgg caacatcaag taccaaagat agagcgatct ctattctaaa
     1621 agggcacgat attctcagct actttgatga gtttgtattt agtgaagatg taacactaag
     1681 caagcctaat ccagaagttt tcttaaaagc ttgcgaaaaa ataaatgtat caactaatga
     1741 ggcaatagtt ttagaagata gtgaaaatgg tattatggct gcctacaatg cacatattcc
     1801 agttatttgt atacctgata tgaaaagacc agcgaaagaa tatttagaga aaactattgc
     1861 tgtttgtaaa acattaaacg atgttattga ttatttaaaa acaaaataac agttaccgca
     1921 taataaaagt aacataataa aaaaagttga atataaagat aggaccaatt tactaattta
     1981 tgcaaaaatg tagttttgaa tctacaaaaa tcgattattt gcataaattt tctaattggt
     2041 cctattgcta tattgcatat ttacttttta tctatttcct tttatttatt tctttccaac
     2101 tcaaccataa acatattaag aatcccaaat atagaactag aaaagtaatt aacattatag
     2161 tacgttctaa ttgcttagga attttaggaa taggaagttt aaataatggc tgatgataaa
     2221 gagggacaac tcctaattgt ggtagagtag agtttttact tcctctattc cttaaaagga
     2281 ttggatgggc ttatttttat agcaaaaaaa gcagaagttg ggttgcttgc caccgcatct
     2341 gcttttacta tctggattaa tacttcaaag attaatgttt ccgtttatga cggttcttaa
     2401 tcttgtccga aataatatca gatattatat ttgttaggat agttagtcct aacatttgta
     2461 gtaggtttag caagaggtat acacctcaat tccggtacag tttaagatgg ttaatcttat
     2521 gtaccaaagg tcattataca ctatgatata agtcaaaaaa atattttaaa gtgatttatt
     2581 gacaaattta tatgctgcta tataatttag atagtaggtt agtaagaggt tagttacctc
     2641 aaaaagaagt tatggttagt taccatttat ttcctccttt ctgttattcc aacagaaagg
     2701 tttttttatt attcttagaa aacataagac accttgtttc tacctattat atgagtagag
     2761 gcaaggtgtc ttttttgatt gaatacgatt tgaatacgtt gaaccgaaac tatggaacat
     2821 tacagtgaac taaatatcat cttttttgtt aaaatggtag ttatagaaag ctttgagaaa
     2881 gctcaaaaaa ttgcacgtta aaacgaagcg tttaaagcta actatctaaa gtggtcaggt
     2941 gataaattgt tatttattat gaatgggagt taaggcacct gttaaaatta gtgcttggac
     3001 gaactttaag actttattta atgagccttc aggttggtgg acaacttatg caagtgggta
     3061 tataggcgat tacttggatt tcactaatcg taaaattata ccagaaagaa aatttaaaaa
     3121 gaagtacaaa attgttaata aataagccta tcaggtgtaa tttgatacct gataggctta
     3181 ttgttatctt cctgaaatca agaaaaattt aataatagaa ataaagataa atagcaattg
     3241 taatccaaaa tcaattctat ttagtggatg cttgtcatca gtagcttcaa aataatggaa
     3301 atgtagcatg gttgtaacca aagaagaaaa ggctagtata ccaagatgaa ttagatttcc
     3361 atcaactaat gtccagatca ataggagtaa agtaattagt gaaacagaaa ttttgctgaa
     3421 attaatatta ttagaaaaac tattcataat ttttacctca attcattata aaagtatttt
     3481 tattattaca tagaaggtaa taaattgagg agatttttcc aatttggtaa taagtggtgc
     3541 ctatctggtt gaaaaaagag aataagaata aaatttagca aaattagaag aaatagtcaa
     3601 aaagagcaga tgaagtgaat aattataagt gtaaattata gctataataa atttttaaaa
     3661 ttatgaggtg ttgaagttat gaataataat tttatacaag ttgataagaa agaattagca
     3721 catataattg gtggaagaaa ttcttatgat tatatagata gcggacagtt tggttatgat
     3781 ataggatgta caatcgctaa taccaaattt ttcaaaagat taagacattc aaatcaaaat
     3841 atttgtagtt aaacagaaat gtaaccaact aggtataaaa cattttatgc taaattgata
     3901 tttgaatacg gaatgataat acaataaaag tgtaagcata tgtttcacaa gtgttttaga
     3961 gaggatgtgt tctatgtgct gaaaaaatta tggaatatct ggttagatgg cggattaatt
     4021 agaggaagga agagatatgt aatcattcca attatttttg caatatttct tcccctatcg
     4081 atgtggttat ccgacaatga aggaatgtct tatttagact atattcaaat gcctaaatgg
     4141 ataatatttg ctgttttttg tctagtaggt ggcagtacac tgctttactt attagatact
     4201 gcgatgaaag taaataaaca tatgaaagga tgattatcat gatgaaggaa tttacagtat
     4261 taacagaatg tgagttagca aaagttgatg gtggctatac gcctaaaaac tgtgcaatag
     4321 cagtaggcgg tgggatgcta tctggtgcaa tcagaggagg aatggcagga actgtatttg
     4381 gagtaggcac aggtaatctt gcgggagcat ttgctggtgc acatataggt ttagtagcag
     4441 gtggattggc ttgtatcgga ggatatttag gcagtcatta aactaggaat gattaaaatg
     4501 atattttggg ttacagtaat agttgtatat agtaccttta tcagtatcta tactagtaaa
     4561 aaagaagatg gacattacaa gttatttgat gagaaagcta taaaaaagaa taagaaaata
     4621 agttataaaa aggcgtggat tttaaatttt atatattggt tttatggttt ttattagtga
     4681 tgcgaggaga tataatcatg agttatgaaa aattaaataa tgaggaattt tctaaaattt
     4741 taggagggaa tggcattaat tggggagcag tcgcaggtag ttgtgccagt ggtgcggtta
     4801 taggtgcagc tttcggtaat ccattaacag gttgtgtagc caattcagct ttttctttta
     4861 gttggcaagc atttaaaaat agacctcgtc ctaaaaaaat agcgtaatta taaattttta
     4921 tagaatagtg tcaaataaaa gctaataagt tatgtttgac gctatttttt aataaggtaa
     4981 aattattctg atgatgatga ggacacatga cattttgggt tacattagca gttccgtata
     5041 ttatctttat cagtatctat actagtaaaa aagaagatgg gcattacagg ttatttgatg
     5101 agaaagttat aaaaaagaat aagaaaataa gttatgtggt agctatagtt ttaagaattt
     5161 catccaaata agcattaaaa tgaaccgaat atgataaaaa acgaataaag tagattaaaa
     5221 aatgttaaac tatatttgta ataaagataa caaaggagag attttttatg aagtttgaag
     5281 tgttaacaga aaagaagtta cagaaaatag ctgggggagc aaccaaaaag ggtggcttta
     5341 aaagatggca atgtatattt acattttttg gtgtttgtaa ataatggtta atttaaattc
     5401 aacatctggt tatatagtag ctacactaat tttatttata aatacttttt gtagatatag
     5461 ttttttttat cttttgaccc ctactaggaa aagtaagaag tataatttat tatttatact
     5521 tcttactttt cctgtaattc ttttaattaa tggtgttgga gatattattg gtttttttgc
     5581 accatttatt gaaattttta ttttttatat tgtatacaga caactaactt tggattacag
     5641 attatgtgga aggttgttaa tgctagattt attttcctac ataacattcg gtgcttcagc
     5701 attatttttt acattattta caaattatta cacaatggtc agtgtgataa tattagatgt
     5761 gtcattaaac atttttgaat atataatttt aacaaagacg actataatag agaaactaga
     5821 tgatgagtat ggattattgt atttttattt aattttatac atatggatta gttcaatggt
     5881 tatttactat ctaacaacat atgtatttaa tatagatgca gtatcgtata ttatagctat
     5941 ggtagttgtt gttagccaat tgttcttttc attatttgta tattccatta ataagaaaat
     6001 acggcaggat aaattaagtt tacaacaaat taatgatcta aaaatttata cacaacagtt
     6061 agaaagtagc cagcgaggtt tacgtaaatt taagcacgat tatcaaaata tgctattaag
     6121 cttgaaactc agtgcaaaaa aaagtcatga taaagagtta atagataaac tagctgaata
     6181 ttcaagtaag actttagaag ataaagtatt atggcagttt aatgatgttg acaatgttaa
     6241 agatgaatta ttaaagagtc tatttatcag taagttgaat agaatctttc aaaacaatat
     6301 tcaatattct tttgaatgtc gaattgtgat agaaaacttg tcgaataagt ataactcgtt
     6361 tgacattgtt agaatattag gaattgtgta cgataatgca attgaagaaa gtcttgagtt
     6421 tggtgatgaa gctaagatag atactatgat ttatcaagaa aatggtgaac ttgaaattga
     6481 gattagaaat cgttatcgag ataccgatct aacaattcaa gatataaaaa aatcaggttt
     6541 tacaactaag aagaatcatg acggattagg attagctaat atagaagaat taagtcaatc
     6601 ttataatgat atttttatta attatcaaat taaagatggt tggtttactt tccttatggt
     6661 tatgagcatt taaggggtag tttaatttgg aagaatatgg aattattatt tgtgacgatg
     6721 agaaggatca agttagaagg atacatgatt tagttaaata tgctatttgg tctttagaag
     6781 attctgctga cagtaaagat aaagagttta aaataacttt ggaagctaat agttatattg
     6841 aagtagctga ctatttagaa gataataaag tggatagtgg agtttatttt ttagatatcg
     6901 agcttagtag ggataaagca gatagagatg ggatagattt agccgaattt attagacaaa
     6961 aagatccaaa tgcacagata atttttatta cagcttatga aaatctagca gcaatgacct
     7021 atcgacgtcg cacaggagcg ttagatttta ttactaaaaa cgatagtgat gaagtgattc
     7081 aaaagagact aaatgaaact ttatcattag ctacaaggag aattagggaa tctcatgcca
     7141 taaagaaaat gacatttagt tataaaatgg gcagaagaat tattaacgaa aatatcaatg
     7201 atattctata tattattacc actcctaagt cacatagatt aaaaatagtt acagttaatg
     7261 gtatgggtga gtttacaggc gatattaaga agttagaggc agaaaatgat tttctagaaa
     7321 aaatatcaca atcttgttta gctaatccaa gtaatattgt tgaaattaac cagtcaacaa
     7381 gggttatttc ttttaaagat ggatataaag agacttttcc tagaagaagt aaggctaaaa
     7441 tgaaaagttt gattgaaagg tataacttaa gaacagtcta atttttttgt gtttattggt
     7501 ataggtggtg aatgatcatg gtagaaacag gtattattat attgctagtt gtagggttta
     7561 tggtaatttc aaggttgaaa gtaaatttta caaaaaatag tagatatgca ggctttttat
     7621 tgttaatatt actggatcta aatgggctta tgcgaacttc tatgttaaca atgagaggtt
     7681 taatcttatt gggaacattg atggtttttg tagttatgtt gattaaagaa attagacaaa
     7741 atagaaaata taattaataa agagggttgg aactagggta ttccaattct tttcaaaatc
     7801 ctgtgtagtc ctaatgttgg atccatagga ttttttattt tctatgtgaa aaaattcaaa
     7861 attctataat aaccacgatt ctgtcactac agagttagaa aaataacaaa cagaagacga
     7921 gtgattatta tggaaaacac aaaaagttta acatccacgc tctcatataa cttattttct
     7981 tattgtattt taaatttttt ttagataatg cccatcttct tttttactag tataaatact
     8041 gataaaaata acatatacga ttataactac aatccaaaat gacatatatt ctactccctt
     8101 aacaccaatg attctatttg aaaaaaatag tgtcaaattt agccaataga ttattagctt
     8161 atatgacacc attcaaaaaa tattttatta tttaatataa ctacctatca tttacgcggc
     8221 ttacttgtaa ctataattac tatccctaca gacattagaa aaatcgaata tattacgcca
     8281 cttcctaaca tcatattgat taaccccata agtatctgac ctatacctat gcaatacata
     8341 agaattctat ctgtcttctt catcaggaat tgtgataccc aatccacgca cctgctcctg
     8401 ctccaactat tccacatcct gttgtgaccc atggtccaaa ttgtttacac actttgatac
     8461 cctcagttgc accacctaaa gcgcctataa aagcatttcc ctagttattt ccacctacaa
     8521 tggtagataa ttcttcaact tttacaacat aaaatctagt catcttaaaa acctcctgtc
     8581 gcacctgtaa ctatagtcca accaataggt gcataatgtg cacctatcat agcacatgga
     8641 actccacaaa ttgcaccacc taatccagtg cctgctatcg ctgcactagc aaatccagcc
     8701 acataagagc tccctttact acctttacca ccatcaacct ttgctaactc acattctgtc
     8761 aatactgtaa attctttatc catcatgata atcatccttt taaatgttta ttgaccttta
     8821 ttaatgtatc tacaacataa agcaatggac tgctagatat taaacaaaaa atagcaatca
     8881 ttatcatttt aggagagcta ataaattcca aaaaaggtat actggcagag ttgcctaacc
     8941 aatcacctag ccaaatgcct aaaggtacaa aaattgctaa attaattgaa aaaagaaagt
     9001 atctatattt ttcctatttt ctagccgtga tgcccataat ttaatcaacg cctttcattg
     9061 acaatgtaag ttatatctta accacactgc tagtatatgt catttctaac ttagataata
     9121 tgaattagcg aaagatgtgt aaaattaaac agaattggta ctattgccaa ataaatctaa
     9181 aaaaagacca aatttgataa tttagacata atgatttaag aatatgataa attgaagcta
     9241 ggaggtgaat tgctatgaaa gtgtataacg aagaaaatct agccgaaatt attggtggga
     9301 gaagtataga aggtaagata tggtatggat atggctacca attagggatg acggcaagat
     9361 ggaatttaag acatccgtat tttcaattac cttatcatta aaagtggagg agtaagatat
     9421 gaaaataaat aaaaagtttt ataaaaatta tactttttat atcggtttag taatgttatc
     9481 aatagcgata ggaagtattt tttttgataa aggatatttt ttatttacaa ttattgatat
     9541 attttttgct tacttaggca taaaatatat ttatcaatca ttggtggtaa caaaactttg
     9601 cgaaagaggt cattaaaatg aataaaaaat taaatagtat agatgaaaaa gatttagtaa
     9661 agattgttgg agggggttct ccatggtcaa acctcattgt tcaaggagca gttgcagttt
     9721 ttaaatctgg atatagacac agaaatgata taaaggcagg atttagtgca ggattttacg
     9781 gtaaataaaa taagaaagct aggaaaaatc aaattaaaat ttactcaatg atttttctta
     9841 gttttttatt ttgataagtc aaagaaacca aataagtaaa aaaaggacca aattcgataa
     9901 tttaggcata ataatttaca gacatgatac actcaatata aaagagatga aagataataa
     9961 gtttagtaaa ggggatatta acttatgata cataaatata aaaaatatta tatcccacaa
    10021 gtagatgaat ctgattgtgg tgtagcttcg ttagccatga ttttaaaaca ttatggttct
    10081 tctgtatcat tagcgtattt aagaaaaatt gctaaaacaa caatggaagg taccacagca
    10141 ttaggaattg ttaaaacagc tcaagaatta ggattagaaa cgcaggcagt aaaagcagac
    10201 atgtcccttt ttgaaatgaa agatattaca tatcctttta ttgcacatgt gattaagaat
    10261 ggaacattat tacattacta tgtggtatta aaagcaacgt ctaaatatat tttaattgca
    10321 gacccagctc aagaagtagg gataaccaaa atgtcatatg aacgttttga agaagaatgg
    10381 acaggtgtta ctttatttat tgctcccggt attgaatata agccagtaaa agaagataga
    10441 aaaaagttat ggtctttatt tactaagtta tttaaacaaa agcagttagt gcttaatatc
    10501 gttttagcag ccttactgat aacaattatt agtatcttag gttcctactt cttacaagca
    10561 gttatcgata catatattcc taatggcatg cgtaatacaa tggcaattat tgcactagga
    10621 ttattagtaa tttatatttt caattcaatt tttacgtatg ccagagattt tctattagct
    10681 gttttaggac aacgactttc aatcgaaatt atactaagtt atattaggca tatttttgag
    10741 ttacctatgg aattttttgc aactagaaaa acaggggaaa ttgtttctcg ttttaatgat
    10801 gccagtaaga ttatagatgc tctagctagt acagtaatat ctattttttt agatgttagc
    10861 attgtagtta ttatgggcat cattttagcc attcaaaacc ttaaattact gggtataacg
    10921 ctcatatcac ttccaatcta tgcagttatt attcttactt ttaccaaagc atttgaaaaa
    10981 ttaaataata agcaaatgga aagtaatgca gtacttagtt cgtctattat tgaagatatt
    11041 caaggtatag aaacgataaa ggctttaaat agtgagcaga ctcgctatcg tagaattgat
    11101 ggtcaatttg tagactattt gaaaaaatca ctagcctatt taaaaactga ttcattacaa
    11161 caagcattaa aactgtgtat tcaacaatct ttaaatgtcg tagtgttatg gctaggggcg
    11221 aacttagtga ttaacaatca actttccata ggacaattaa tgacttttaa cgccttatta
    11281 agttattttg taaatccatt gcaaaatatt ataaatttac agccaaaatt acagagtgca
    11341 agagtagctc ataatcgcct aaatgaagtt tatttagtgg aaagtgaatt taaagataaa
    11401 aaagtcattc atgatgttca acaacttcaa ggagatattg agtttgaaga tgttgattat
    11461 cgttatggat atggagaaaa tgttctagat aagattaatt tgacaattaa gcaaagagaa
    11521 aaattaacaa tagtggggat gagtggttct ggtaagtcaa ctttagttaa actattagta
    11581 aatttttttg aaccaacttc aggaatttta aagtttaata atcatagtag taatgaaata
    11641 gataaacata tcttacgttc ttatattaac tatgtaccac aaaatcctta tatattcgca
    11701 ggaaccatag aagataatct taaattgggt aatcgtatta atgtaacaga tgaagatatt
    11761 tttaatgcat gtaaaattgc gatgattgcc gaagatatag ctaagatgcc actgcaatta
    11821 agaacagaac tagacgaaaa tgctaatact ttatcaggtg gacagaagca aagaattaca
    11881 attgctagag ctttattatc gccagcacaa gtattgattt ttgacgagtc tacaagtgga
    11941 ttagatgcaa ttacagaaaa aaggttaatt gataatttaa tgcaattaaa agataagaca
    12001 attattttta tcgcacatag attatcaata gctaaacgaa cagataatat tttagtatta
    12061 gataatggaa aaatcgtgga acaaggtaga catgatgaat tgttagcaca agagggatac
    12121 tactacaatt tagttaatag ttaggggtgg aattatggaa gataaatttt tagaaagtag
    12181 tgaattttat tctactagat ttagaaactt ttcaactatg attattatcc caactgcaat
    12241 tttactgttg ctagtaatca tgtttggctt ttttggaaaa aaagaaataa ctattaaagg
    12301 agtagggaca cttgaagctg tgggaactaa tcctgttatt caagcaactg taaatagtcc
    12361 tattgaaaag aactatttag aagaaggtaa gtatgttaaa aagggtgata cacttcttgt
    12421 atataataat gtaaatatca gggataaaga gaaattatat aactatcaaa gagaaacttt
    12481 aaatcaacag ttagaagcat taaatttact caaacaagga atacaaacga atcaagatac
    12541 ttttggaagt gatgatgaat ttggatacca taatgagtta gatagttatt tagaacaaag
    12601 aaatacatat ttgacagaaa atacaatgat acaggaaaaa gcaaaaaatg ataaagcaaa
    12661 acaaagctcg atttctagcg aattaaaaaa gcaaggagag ttgtcatcaa gtatacctga
    12721 ttttgactca tcaaaatatg acgttgaaat aaataatcaa aaacttcaag agttacaatc
    12781 aagtaagcta aactctatta atcaagaaat tacaaaagtt aaacagaatc ttcaagagat
    12841 agatacaaat atcagtgata ataataatgt taataaggaa tataaggtaa cagccattaa
    12901 aaatggaatt ctacatatta acaataacta taaaggaagt agatatgtaa gtgcaggtac
    12961 aaatctagca cagatattgc cagtattaaa aacacaaaaa acattgaaaa ttaatgcata
    13021 tataagtacg gcagatattt cttccattaa ggtagggcaa aacataaaat ttaaagtaat
    13081 cagaaatgtt cctaagccaa ttattttaac aggcaaaatt tataagatag gtgtttctcc
    13141 agtaacggta gaaaaaaatg attactatca agttgaagca aaagtcaata ttaatgatag
    13201 taataaagat ttactaaaat atggtatgca aggacaaacg acagtaatta cagggaaaac
    13261 aacatttttt gagtactata aaaataaatt attagacaaa taaatcattt actacggttt
    13321 ttacaacatt tactacatct tatgctattt atttaattta tattctataa taggagatat
    13381 tgtaaattaa agaagtgaga aagatgatat ttagtcttat cattttaata atggtagtta
    13441 ttgctgtata tctaatatgt aaagatatta taaataattt aaataatcgt ttgtaagagc
    13501 cgtgagattt catggctctt ttttaggggg atttctagtg aacttagaat tattaattcc
    13561 tattagttta tcaataggaa ttgtactatt gtttaacaca tatcaattta aaagaatgaa
    13621 tatagtatca atcataaata tctgtatagc gtttatttta tcactgtata atgggattta
    13681 ttaccatgaa agatatttac tgttactttt ggtattggta attgaagtaa tagtaataaa
    13741 caaaaaaatt ataacagtag atatagcagt attattaatt atttatttat tttttgtttt
    13801 agattataat attttacttt ttttaacaca tttagttggt acaatagcag gaaaaattac
    13861 gaaatttgat gaatttttaa taggtgtgtt aattatagtt agtcttatag tggtttattt
    13921 gttactaaag aataatcgaa ataagattaa taaaattatc gaaactataa aacataatac
    13981 aatcttatta aaaaccatta tatcagtagt gctaatctta ttattttctg aaagtttgat
    14041 attattttta gtggatatat atggaataag ggaattggta caaggttttc taattgcttt
    14101 tttaggtatt gtaacaggaa taattttact tattttagat tattatatag taatgtatca
    14161 agaaaaagta cagtataagt tgcaacgtga aaaatatatt caacaagaga agtatttatc
    14221 tgctttagag aaaagttatc aagatttaag aaaagccaga catgattatc agaatacttt
    14281 gttagccatt caaggagcta taaatgaaaa aaatatatta gaagcagaaa attatttaaa
    14341 agagatattg aaacaaacca ataatgatac taaaaatgaa gctaagattt tatttaatct
    14401 aaataaaata aaattatctg gaattagaaa tctattagca gtaaaaatta aaaaaatgca
    14461 agaatttgga attaaatata caatggaagt tatagatgat attgataatt tgccggggga
    14521 tattgtcagt attgtaagaa ttatagggat attggttgat aatgcgatag aggcatcaca
    14581 aaatcaggat aatccgcaga ttaatctggc actgattaag tataattcta aagcttacag
    14641 tttttcgatt gtgaataaaa ttaacaaaaa agtcgaactt aataaaatta ttgaacgagg
    14701 atatacaaca aaagaaaatc atacaggttt agggcttgat aatgtattac agttggtaga
    14761 aaaatcagaa aattttactc ttgaaatcaa tcaaagcaac aatacgatag aatttgactt
    14821 tatgatggag ggaatgtaga tgctaaaagt attaatattg gaagataata atcttcagcg
    14881 taaaaccatt agtcaaattg ttcaaaatag aattatgatt aataatacgg ataaatcata
    14941 tgatatggaa attacaattt caactgataa tccagtagat gctataaatt atgtggaaaa
    15001 tcatagagaa gaaatggtac tagctttttt agatatagat ttaaaaaata aacaaattaa
    15061 tgggcttgat attgcggagc atattcgaca atatctaaga tttgcagaaa ttgtttttgt
    15121 aacaactcat caagaattaa tgccattaac tttacgaaag aaagtcgcac cattagattt
    15181 tattgataag gataacaata tgactgacca aattagagaa tgtgtagata tagcatatga
    15241 acattatcaa aaagaaatta gtggtcctag taaaagtact cttacttatg agattatgaa
    15301 tggtatatat aagcaaatat taattgagaa aatatacagc tttgaatcaa taaagggtaa
    15361 taataggcat ataaaattaa ttgcggaaga tgcagtagct actattatcg gtaacttaag
    15421 ggatattgag caaaagaatg aagaattttt tagatgtaat agaaatacag taataaatct
    15481 tattaatatt gagcaaatag atttaaattc caaaataata aagttaaaaa acagtagcat
    15541 atataatata agtactagaa aaattaagga tattaaaaaa attctaaaaa gtagatagaa
    15601 ataaaagagg ctgggaaaaa actatatttt cagataaatt ttagaaaata gttatattaa
    15661 aaaccgctag gaatcaacgt ttttagtaac gtgatttcta gcggtcttta agtcttgaga
    15721 cttttttccc agactctttt tgttagctaa ttattattta ttttttctat aaaatttaat
    15781 atttgcaaat aataatacaa ttaaagttgt aatagttatc caaatattaa gagaaaataa
    15841 actatgcatt aagataattt ttgctagact tattaaagaa aatagtccta acataactga
    15901 taatagtata atatttaatt tcattaaaat cgcaagtctt ctaaaaagtt aatgtaactg
    15961 taatattccc aacataatga cccgatctta taaagacatg cttaattctt atcttttgaa
    16021 tatttagcat gtctaatttt tgcagcaatt aatataataa ataacggaac aattccatta
    16081 acttgtccac gagtgaaaat atctacaatt attagaagga acgtaataat tataagtatt
    16141 gattttagtt tatcgtattt cataataatc attccttact ttataaatga catcaaatta
    16201 agaataaacc tgcaaccgct ataccccata aagcagcttt accggtataa tgaccgatac
    16261 gaccggctaa ccgattatac ccgccgttta catgagacaa tgtagtgtct gaaattattt
    16321 caaatttttg taaattattc atagtaatca tccttcttga tattaataac taaattgcat
    16381 taagaaaacc ttcaccaaaa ctaactactg catcaacaat gtggtatccc aaaccgtgtt
    16441 taccaccaat aataccctgt aattctgtat tatttaatga tgtaaaattg ttacaattat
    16501 ccataaaaaa gacctcctaa aaattatatt tagtaactgt taacaatgta tagtatatac
    16561 gcattttaca gcaaaagaga aaaatgtatt aaatgtataa aattacgtat taagtgataa
    16621 ttattatcat agaacagcat ttaattcact tgaagtacta tttaatacaa taattatgac
    16681 aattcataaa catattcatt aaaatcaaca ttcaacaaat tttgacgata atatactagc
    16741 gacttaatag atagatgaag atgattcaaa agctcaattt cagacttatc tttattagta
    16801 aggagataat tatagatata gctttgtctt aattttgaag gagctagtgt catattcaaa
    16861 atttcttcat caggtctaac tctcattaat aatgaattta gcgaattcaa tggtttctca
    16921 ggatcgtttt ttagtgagaa tacgaaataa ttatcgggtt ttacttcaat attatctagc
    16981 aaaattccaa tattttctgt attaaagttt cgaagctgtc caaaagtaat attaagtaat
    17041 ccctttggtt cgatattttg agagattaga aaaagttcta attttgcatc atcagaaagt
    17101 tccgcaattt tgaaaatttc aggtagatat tgctgccaac caag
//
