LOCUS       c00009_gnlPro..        13292 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FGGCBLHG_11.
ACCESSION   c00009_gnlPro..
VERSION     c00009_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 05:49:54
            Original ID  :: gnl|Prokka|FGGCBLHG_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13292
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13292
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[767:3292]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      768..3292
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13292
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13292
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(2..148)
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="LKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVRN
                     HISN"
     CDS             complement(264..707)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_2"
                     /sec_met_domain="HBT (E-value: 9.9e-14, bitscore: 45.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 2.6e-10, bitscore: 34.4,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPAYIDMPFQEWKTSFSFFNEVSVRFSETDMFGHMNNVTPFIY
                     FEEARISYFKQLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLTLH
                     YLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR"
     CDS             complement(768..1529)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 96.2; E-value: 3.7e-30)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-29, bitscore: 96.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 2.9e-11, bitscore: 37.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00071, bitscore: 13.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIRR
                     NPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKTFP
                     VVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGVCLE
                     ACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLQDCGNSQNCVQSC
                     PKGIPLTTSIAALNRDTNLQAFRNFFGSDRV"
     CDS             complement(1532..3292)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 296; E-value:
                     1.7e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.9e-90, bitscore:
                     296.0, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.4e-42,
                     bitscore: 138.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCA
                     QGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFN
                     RTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFLGA
                     VLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQ
                     QGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGN
                     LVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFMGDDP
                     RKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGG
                     MVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEW
                     MTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARV
                     ITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQDVDVSLITPRK
                     RDYSKKKVAK"
     CDS             complement(3326..3934)
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNSA
                     AHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVTGI
                     ITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGLWSF
                     AVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV"
     CDS             4227..4673
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYWA
                     GKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEPCF
                     QLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV"
     CDS             complement(4717..5943)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_kinase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_7"
                     /sec_met_domain="AA_kinase (E-value: 2.5e-55, bitscore:
                     181.1, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGK
                     STDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGIRT
                     EAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVALAAA
                     LKADKCDIYTDVPGVFTTDPRYVKSARKLAGISYDEMLELANLGAGVLHPRAVEFAKNY
                     QVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFT
                     TLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAK
                     VSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAF
                     ELSKHPSAV"
     CDS             complement(6313..8085)
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYF
                     TGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFIKL
                     THERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCLYYH
                     LGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELR
                     DQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQ
                     EADEEFLTFIGQFYSKNNHFLPKEILVPDSVDQSMIEQLLETNVHQPKKGPKKELLMLA
                     HKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMI
                     VFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQ
                     INAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGEPLEVVYLERNSQEFYLLQRIQDE
                     VHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEASLEDIKKAGV
                     PAAAAQLLYDKLQK"
     CDS             complement(8221..8535)
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQE
                     MGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNKHL
                     "
     CDS             complement(8858..10366)
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MKGMIRGMSEHQAVIQTDIVKGTINKNIYGHFAEHLGRGIYEGIW
                     VGTDSDIPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGG
                     TIESNEFGTHEFMMLCELLECEPYICGNVGSGTVQEMAEWIEYMTFEEGTPMSDWRKQN
                     GREEPWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDD
                     FNWTDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQ
                     KHGTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQH
                     CRRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW
                     NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKMN
                     AHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS"
     CDS             complement(10563..11540)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ETF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 153.8;
                     E-value: 1.5e-47)"
                     /gene_kind="electron_transport"
                     /locus_tag="ctg9_11"
                     /sec_met_domain="ETF (E-value: 4.4e-47, bitscore: 153.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 2.8e-37, bitscore:
                     120.2, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGENV
                     QSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKDLS
                     PKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNIQAS
                     EKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSMEGFQPL
                     QELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNS
                     KVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKKLNIHS"
     CDS             complement(11576..12349)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 160.1;
                     E-value: 1.8e-49)"
                     /gene_kind="electron_transport"
                     /locus_tag="ctg9_12"
                     /sec_met_domain="ETF (E-value: 5.1e-49, bitscore: 160.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEAI
                     QLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLEEPDQYSISQVLYHY
                     MKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVEGDV
                     EKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKLKTIE
                     RFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI"
     CDS             complement(12364..13140)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ECH_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_13"
                     /sec_met_domain="ECH_1 (E-value: 1e-63, bitscore: 208.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAISLAVDQFVAVLAIHNPPANALSSRILEELSSCLDQCEIDAG
                     VRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIHGA
                     ALGGGLELAMACHIRIATEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIGSGE
                     PISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVYSYEG
                     SLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE"
ORIGIN
        1 catttgaaat atggtttcga acggttttct cactgataaa tagctcgctt gcaatctcct
       61 ttgttgtctt atcttgaacg agcaattcga acacttctct ttctcttttc gttagcagcg
      121 gcttcgattg aaattctttc tccttcaagt attgtaaccc tccttgctaa ggtgagagcg
      181 aatcagaaac gaatgggttt tgatatagtc gagatatcat atgtaagaag ggcgcaggag
      241 gtgacgttta caagataatt agtttatcgt gtatgaagga gcgtttcttt ctcctcatct
      301 gtccagctga cagccttgcc gctttccttt gagacttgaa ccatcacgac tgccccggtg
      361 aagcagggtt cgccttcgag gttctctccg agatagtgca aggtaagaga tgaactgccg
      421 actgcgcttg ttttcacata gatgcgcaac tcttcataag gcatgacttg gcgcaaataa
      481 tcgcattgct ggcttgccac gactgtcatg gtctgtttgt tttcactcat catattcagc
      541 tgtttaaaat aagaaatccg cgcctcctca aaatatataa aaggggttac attattcata
      601 tgcccaaaca tgtctgtctc ggaaaatctt acggatacct cattgaaaaa agaaaaggat
      661 gttttccatt cttgaaacgg catatcaata taagcgggaa gcttcatctt ttttcatctc
      721 cttattgttt aaaaaaacct ctcccatgcg gaagaggttt tttcttctta tactctgtcg
      781 cttccgaaga aattgcggaa cgcttgtaag tttgtatctc tattcaaggc tgcaatcgaa
      841 gtggtaagcg gaatcccctt cggacaggat tgaacacagt tttgcgagtt accgcaatct
      901 tgaaggccgc cttcatccat taatgcttct aatcgttcag atttattcat agcgcctgtc
      961 ggatgcgcgt taaacaggcg gacttgcgac atcggtgcag gccccatgaa cttcgatttg
     1021 ctgttcacat tcgggcaagc ttcgaggcag acgccgcatg tcatgcattt tgataattca
     1081 tatgcccatt gacggcgttt ttccggcatt ctcggccccg gtcctaaatc gtacgtaccg
     1141 tcaatcggta tccacgcttt aacttttttc aatgaatcaa acattctgct gcgatcaacc
     1201 tgcaaatcac gaacgactgg gaatgttttc attggtttta aacggatcgg ctgttcaagc
     1261 tggtcgataa gcgccgtgca agactggcgg ggttttccgt ttatgaccat tgaacatgcg
     1321 ccgcatactt cctcaagaca gttcatatcc catgtgacag gggttgtctt ctcacctttg
     1381 acattaaccg gattccggcg gatttccatc agagcggaaa tgacgttcag attcgggcgg
     1441 tatggaatct caaattcttc atcgtaaggc gtgctgtcgg ctgtatcttg acgtgtgata
     1501 ataaatcgta tggttttttg ttcactcatg attatttcgc caccttcttc ttcgagtaat
     1561 cccgtttccg aggcgttatc agtgatacat cgacatcctg atactcaaat tccggcgctt
     1621 catacgggct tacatgttta gccattgttg ttttgagcca ttcgtcatca ttacgttcag
     1681 gataatccgg tttataatgg gcgccccggc tttcattacg gttgtatgcg ccaagggtaa
     1741 tcaccctagc aagctgaagc atgttcgaga actggcgtgt gaacatcgct ccctggttgc
     1801 tccattttgt cgtgtcattg atgttgatct ttttgaagcg ctccattaac tcctgaattt
     1861 tgtcatccgt tttcaaaagc ttgtcattat ggcggacaac cgttacgttc gccgtcatcc
     1921 actcaccgag ctctttgtga agaacatagg cattttcggt tccgtccata ctcataatat
     1981 cagcccattt ttcttcttct ttcttaacgt gagcgtcgaa taatgatgaa gacatgtctt
     2041 ccgctgaaga ttctaagccg tttacatatt tcaccgcatt cggtccggcc accatgcctc
     2101 cgtaaatcgc agacagcaag gagttcgctc ccaagcggtt gccgccgtgc atagaataat
     2161 cacattcccc agccgcaaac agtccaggga tgtttgtcat ttgatcgtaa tccacccata
     2221 aaccgcccat agaataatgg accgcaggga agattttcat tggaagctta cgcgggtcgt
     2281 ctcccatgaa tttctcataa atctcaatga tgccgccaag cttaatatca agctctttcg
     2341 gatctttatg agacagatcg agatatacca tgttttcacc gttaatgccg agcttctggt
     2401 tcacacacac atcaaatatt tcgcgtgtcg caatatcacg cggcaccagg tttccgtatg
     2461 ccggatattt ttcctccagg aaataccatg gtttgccgtc tttatatgtc cacacgcgac
     2521 cgccttcacc acgcgctgat tcactcatca gtcttaattt gtcatcgccc ggtatggctg
     2581 tcggatggat ttgaatgaat tctccgtttg cataatacgc tccctgctga taaacgattg
     2641 atgcagcaga tcctgtatta atcatggagt tcgttgattt tccaaagatg attcccggtc
     2701 cgcccgtcgc cataatgaca gcgtctgaac ggaaggattc aatttgcatg tttgtcaggt
     2761 tttgcgcaac aattccgcgg caggttctgt catcatctaa aacagcgcca aggaattccc
     2821 agccttcgta ttttgtgacc agacccgcaa cttcgtatct gcgcacttgc tcgtccagtg
     2881 cgtaaagcag ctgctgtccc gtcgtcgcac cagcataagc agttctgtgg tgctgtgtac
     2941 ccccgaatcg gcggaaatca agcaggcctt caggcgtccg gttaaacatg acgcccatcc
     3001 ggtctaataa gtggatgatc gaaggcgccg cttcacacat cgccttgact ggcggctggt
     3061 tggcaagaaa gtctcccccg tataccgtgt catcaaaatg ttcccacgga gagtcacctt
     3121 ccccttttgt attgaccgct ccatttatgc cgccttgcgc acaaactgaa tgagaacgtt
     3181 tgacaggaac gatggaaaac aatttaaccg ccattcctga ttccgctgct ttaattgtcg
     3241 ccatgaggcc ggcaagaccc ccgccgacta cgataatgct tgattgactc atgatagccc
     3301 ctctccctct agtaatctag tactcttaaa caaatgcgaa aatcgctttt aagcctacgt
     3361 atgacagtgc aacaaaaata atcagcgtaa cgtatgtcga aattctttga gaacgaggcg
     3421 ttaccgtgat gccccatgta acagcgaaag accataaacc gttcgagaag tggaaaattg
     3481 ttgataaaac accgacaatg taaaaaccaa gcatagccgg agagctcaaa atattcgcca
     3541 tcatgtcgaa attgacctca gcacccattt gtgcggcaat gcgggtttcc cacacgtgcc
     3601 agctgacgaa aatgagggtg atgataccgg ttacacgctg caggacgaat agccagtttc
     3661 tcatgtagct gtattggcct gcgttatttt tcgcagtaaa cgctatgtac acaccataaa
     3721 ctgcatgata aattaatggt aagaagataa taaaaatttc caaggcatac ctgaaaggca
     3781 gactatccat aaaatgagca gcgctattga atgcttcagc gccccttgcg gcaaactggt
     3841 tgacgactaa atgctgaatg agaaagatgc cgaccggtat gacgccaagc aaggaatgca
     3901 atcttcgaaa ataaaactct ctgttcccag acattacttt accccctgtt tgataagtgc
     3961 gaaatgtgct aaatctcttc ccccacttct ttcaattgta agcactttat taagatttat
     4021 tgacaatttc attttactcc tccctcaaaa gggcgtcaag aaaacgcgta cataaattat
     4081 aattttccga attgattagt tgattgaaaa attttatttt atcaatatat atttcttgct
     4141 taatttttca taagaattac aggatcattc tgtaatcctc ccccctgttt gagctataat
     4201 atacgcagga gagaggggag acagatatga agtctaaatt tgaagcatct attgacaacc
     4261 taaaagaaat tgaaatgaac gcctatgcct acgaactaat acgagagatc gttctcccag
     4321 atatgcttgg ccaagattac tcttccatga tgtattgggc aggaaaacat ctcgcccgta
     4381 agtttcctct tgaatcatgg gaggaatttc cggccttctt tgaagaagcg ggctggggaa
     4441 ccctcaccaa cgtaagcgct aaaaaacagg agcttgaatt tgaacttgaa gggccgatca
     4501 tttccaaccg gcttaaacat cagaaagaac cttgctttca gctggaggct ggttttatcg
     4561 ctgaacaaat tcaattgatg aatgatcaga ttgccgaatc atatgaacaa gtgaaaaaga
     4621 gagccgataa agtggttctg actgtgaaat gggatatgaa agacccagtg taatcaaaaa
     4681 ggcggtgact gcatagtccc gcctttttga ttgtcattac acagctgaag ggtgttttga
     4741 aagctcaaat gcatcgtgaa gcgactcgac tgctttcacc atgtcatttt cgcttacgac
     4801 tgttgacact ttgatttcag atgtgctgac cattttgatt aaaatgtttt tttgcgccag
     4861 tacagcaaac atttcagccg ctacaccggg atttgagacc atgccggatc caacaataga
     4921 tactttagcc aatttgcttt ctgtctcgat tttctcaaat tccagcgcgt ctttatactc
     4981 ttcaagcacc gcaacggttt ggtctgcatc ttctgttttg acagagaagg aaattccagt
     5041 cttgtcctcg gcctgcgttt ggataatgat atccacgttt atgtttcttt tggcaagtgt
     5101 cgtaaaaata gtagacaaag ttgtcaggcc gctagtcagc ccgtaaatgg ttactcttgt
     5161 gatttgatct tcaaatgcaa tgcctctgac aattaaattc tgttccatgg atgattcctc
     5221 ctcaattaat gttcccgctt cggtttctgt acttgaacgc acttctaacg gcacttggta
     5281 atttttcgcg aactcaactg ctcttggatg aagaacgccg gcgcctaaat tggcaagctc
     5341 aagcatttca tcgtatgaga tgcccgcaag ttttctcgct gatttcacat agcgcggatc
     5401 ggttgtaaac acgcctggca cgtctgtgta tatgtcacat ttatcagctt ttaaagcggc
     5461 agccaaagca actgctgttg tatctgaacc gccccggccc aatgtcgtaa tttcacaatc
     5521 ctctgtcatg ccttggaatc ctgcgacaat gacaattttt cccttttcaa gctggtctgc
     5581 taaaaccgat gtgtctatat ctgtaattct ggcgtttccg tgaatggcct ctgtacggat
     5641 tcccgcctgc cagccagtat aagacacagc gtcatagcct ttttcctgca atgccattga
     5701 aaggagtgaa atcgtgacct gctcgcctgt cgccagcagc atatccattt cgcgtttgct
     5761 cggctggtca gaaatagctt ttgcaaggct gaccaattcg tcagtggatt ttcccattgc
     5821 tgaaacgacg acaacgactt gatggccttt ctgtttttct gcaattgcgc ggtttgccgc
     5881 attttgaatt ttttcgactg agccgacgga agtgcctccg aatttttgta caataagacc
     5941 catgtattac caccctttac attttggttc gtgcgggtga ggagaaagag cgctttgtcc
     6001 acaataaaaa aagcaatgag aggaatactc tcattgctta tcaattaatc atcataaatg
     6061 attatgaaca acgagatagc cctccaagaa aatgatttct tgacagcctt acatttattc
     6121 aatgcacggc cagcaaataa taccgatggg gttttatttg cttcggcgac gctccccttt
     6181 cagccttttt cacagaatcc atctttctcc aaaggcatac tcttgaagtt cgcacctcta
     6241 tcttcaccat ataacacgat ctaactatga aattagttca cattttatca gatcttattt
     6301 aaaaggacaa cattattttt gcaatttgtc gtaaaggagc tgagccgccg ctgcaggaac
     6361 accggctttt ttgatgtcct caaggcttgc ttccttcatt tttttaacgg aaccgaaatg
     6421 ctttaacagc attttctttc ttttctctcc gatacccggg atgtcgtcca aaacggattg
     6481 aaacgcgctt tttccgcgga tttgcctgtg aaaactgatt gcaaaacggt gcacctcgtc
     6541 ctgaatgcgc tgcaggaggt aaaattcctg gctgtttcgt tccagataca ccacctccag
     6601 cggctcaccg atcagtaaat ttgaggttct gtgtttttca tctttcgcta aaccggcgat
     6661 cgggatatcc aagccgagtt cattttcaat gacatccctt gctgcgttga tctgcccttt
     6721 tcctccgtca atgataatca gatcgggcag cggcagattc tcacgaagca ctctcgtata
     6781 gcgtcttctg acaacctctc tcatagaacc gtaatcatcc ggccctgtaa cggttttgat
     6841 tttatatttg cggtattcct ttttgtatgg tttgccgtcg ataaacacaa tcatcgcgga
     6901 aaccgggttt gtcccctgta tgtttgagtt atcaaacgct tcaattctgt gcggcgtata
     6961 aatatttaat gcctcaccta gtttctgcac agccccgatt gaacgctcct cgtcgcgttc
     7021 gattaaagag aatttttctt tcaatgcgat tttcgcattt ttatgggcaa gcatgagcag
     7081 ttcttttttc gggcctttct tcggctggtg aacgtttgtt tccagcagct gctcgatcat
     7141 ggattgatct acgctgtccg gaactaaaat ctccttcgga aggaagtggt tgttttttga
     7201 atagaactgc ccgatgaacg tgaggaactc ttcatctgct tcctgataaa gcgggaacat
     7261 gctgacatcg cgttcaatga gcttcccttg gcggatgaaa aagacctgca cgcacatcca
     7321 gcccttatcg tacgcgtacg cgaatacatc acggtcgact agatcgttca tcgtcatttt
     7381 ttgtttttcc atcgttgatt caatatgggc aatttggtca cgaagctctt ttgctcgttc
     7441 aaactcaaga ttctcagcag cttcatgcat tttctcttca agctcttttt tgacctcatt
     7501 atagccgccc cttaagaaac gtgtaatgct ttcaaccagc tctctgttcg tctcttcgga
     7561 aatatccttt acacacggag cgaggcattg gcccagatga tagtaaaggc acactctgtc
     7621 cgggagcttg gagcattttc tgagaggata cagacggtcg agcagttttt ttgtttccct
     7681 tgctgcctgt acattcggat acggcccgaa atagcgccct ttgtcttttt tgacattgcg
     7741 ggtgacaatc agccttgggt ggcgttcatg ggtgagtttt atgaaaggat aggttttgtc
     7801 gtctttgagc atgacgttgt atttcggatc atgctttttg atcagattca tttctaaaat
     7861 aagcgcttca agattggagg acgtcacgat atattcaaaa tcctcgattt ccgtcacaag
     7921 cctttgggtt ttcgcgtcgt gagaaccggt gaagtaggag cgcactctgt ttttcagcac
     7981 ttttgctttc cctacgtaga tcacagtctg ctgccggtcc ttcatgagat aacaacccgg
     8041 ttgatcagga aggagggcga gtttttcttt cagttgtttg ttcatatgtt acccttcctt
     8101 atgtttaatc ctttatttcc agtttaacac gaacgtttgt ttttctctat ggttcacaat
     8161 tggcgaataa aaaaagcgat ccctcaatcg gaatcgctct ggcatgtaag cagcggaaaa
     8221 ttaaagatgt ttgtttacaa gctcttgaag cgcttctttt ggtttgaagc cgactgaagt
     8281 ttcaactact tcgccgtctt ttaacacaag aagagtcggg atgctcataa cgccgtattt
     8341 tccggcagtt tcttggtttt cgtctacatc gatttttacg attttcagtt tgtctcccat
     8401 ttcttgatcc aattcttcaa gaacaggtgc aatcatttta caaggtccgc accaaggagc
     8461 ccagaagtct gccagtacga cgccttcgct tgtttcagct gagaaagatt gatcagttgc
     8521 ttttacgata gccattattg aattcctcca atgtgaaatg atgattttta gtatagcatc
     8581 tcccattcgt tcacgctatt ttaatgctta caaattattt tttcctgatc acagccggtt
     8641 tactcatttt tatatggttg aatgggatat gctctttttt taaaacacaa atctgataat
     8701 ggccccgatc actacaattg ccccaataat cattaaaatg gtacgaagca taagatcaca
     8761 tctcctcttc actgtcatgt actttaccat gccctgccgg agctgtttta aaacctgaaa
     8821 aagagcgccg gcatgaagct ccggcgctct tgcgcgatta agaatcagca cgcagcgtaa
     8881 gcaagacgac tgacattggc gggagtttta ctttcagttt gtttttgctg agcgtgtatt
     8941 gtctgaagga ttccggtttg acatgatgag gatcgtcaaa cgtgttatgc gcattcattt
     9001 tttctgccgt aagaatgact ccggaatggt ccgctgcctt gtgtaggccc ctcagctcga
     9061 tttccgcctc tgctttgttt tggtgatcga tgttgcaaat tgtgatattg atatcgcctt
     9121 cagcttgttt cgacgctgaa atgctgattt gcggaagcgt ttcaccgttc cattcatagt
     9181 cggcagacat tgtctctgtg gctaaaagag aagcgtcctg gtgcacctta aacatattga
     9241 atacatggta cgtcggtgtc aaaagcatcc gctctccctc agtcaaaatc atcgcttgaa
     9301 gaacatttac tgtttgggcg atgttggcca tttgcacccg gcggcaatgt tgatggaaaa
     9361 tgtggaaatg agaagccgcc accagtgcat cacgaatggt gttttgctga tataaaaaac
     9421 cgggattcgt gcctggctcg ggatcaaacc acgtgcccca ttcatcaata atcagcccga
     9481 cccgctgctc cggatcgtac cggtccataa tcgtgccgtg tttttgaatc aattcatcga
     9541 tgtatttggc ttttttcatc gtaataaacc attcatcttc cgtgaattct gtggctgatc
     9601 ctttgccctt ccagaaatcc cccggaatcg tgtaataatg aagactcaac ccgtccatca
     9661 ggccagcggc ttttttcata agcacgtccg tccaattaaa atcatccaca tttgcgccgc
     9721 ctgcaatttt ataaatgtca ttcccgctgt aattgcggac ataagtctga aaacgccggt
     9781 acagatctgc gtagtattcg ggatgcatgt tgccgccgca gccccagttt tcattgccca
     9841 cgccgaaata tttcagcttc caaggttctt ctcttccatt ttgctttctc cagtctgaca
     9901 tcggcgtgcc ttcttcaaat gtcatatact caatccactc cgccatttcc tgaacggttc
     9961 cgcttccgac attgccgcaa atatatggct cgcattcaag cagctcgcaa agcatcataa
    10021 attcatgcgt tccgaattca tttgattcaa ttgtaccgcc ccagtgagtg ttcagcattg
    10081 tcttacggtc accgacaccg tttgcccaat ggtattcgtc cgcaaaacac ccgcccggcc
    10141 acctgaggac aggaatgtgc agctgtttga gcgcctccag cacgtccttt cgtatcccgt
    10201 tgatattggg gatgtctgag tccgttccga cccagatccc ctcataaatc cctcttccta
    10261 aatgctcggc aaaatgaccg tatatatttt tgttaatggt tccttttacg atatctgttt
    10321 gaatcactgc ttgatgttca gacatgcctc tgatcattcc tttcatacgg atatgaaaag
    10381 caccacagtc aaatatgtga tctgtctttt gcctgaggag tcagcatgaa tgtaagcgct
    10441 tttaaagtaa ccatattata tatgttcgta catgtcaacg acattttcta ttgtttttat
    10501 atttgtacgt acgtatttat aaatatgaaa aaatcccgaa cttttaaagt ccgggatttc
    10561 ctttatgagt gtatattcaa ttttttgaat tcctcagtta ataacgggac aacttcaaat
    10621 aaatcaccga cgatgccgta atccgctatt ttaaagatat cggcttcggg gtctttattg
    10681 atggcgacga tcaccttgct gtttgacatg ccggccaaat gctggatggc gccggaaatg
    10741 ccgcatgcaa tgtacaaatc cggagtgacg actttcccgg tctgcccgat ttggagagca
    10801 taatcgcaat aatcagcgtc acatgccccg cgagaagccc cgactgcggc ccctagcacc
    10861 tctgcaagct cctgcagcgg ctgaaatcct tccatgcttt tgactcctcg gccgcccgca
    10921 acgataattt tcgcttcgga gagatcaaca ccgtccgccg tttttttgac gacctcttgg
    10981 ataacagtgc ggaggtcagt aagagaaaca tcaatgcttt cgatgctccc cgatctgctg
    11041 gtgtcttttt ctgaagcttg aatgttattg gggcgaattg ttgcaaagat catcggatcg
    11101 gttgaaatga cacgttcaaa agctttcccc gagtaaatcg gccgtgtgaa cacaacattt
    11161 cctccggtaa cgcttacatc tatagcatca gaaattaagc ctgtttgcag ccgggcagca
    11221 agcttcggtg aaagatcctt gcccattgcc gtatgcccga agatgactga atcaggattt
    11281 tcttgctcga taacacctct catgacctgg ctgtacccgt ctgccgtgta tgttttcagc
    11341 ttcgggtcct cagcggtaag aactttatct gctccgtaat gaataagctc ttgtgcaatg
    11401 ctttgtacat tttcaccgat gagaacaccg atgacttccc catctcctga aatggttctt
    11461 cctgcagcta ttgcttcaaa ggtgacattc cgcaattccc catcgcgtat ttctccaagc
    11521 acgatcactt tttttcccat tctaacatcc ccctgtttct ttgaatgtcc aagctttaaa
    11581 tgactttagc ttcgctgcgg agcaatgaaa caagctcttt tgcctgttca gcaggctcac
    11641 cttggagaag cttcccggct tcttttttcg gcggcagaaa acgttcaatg gttttcagct
    11701 ttggttcagc atcctcttcg tccaggtcaa gatcatcaag ttcaagctct tcaagcggct
    11761 ttttcttagc cttcataatt cccggaagcg atggatagcg cggctcgttt aagccctgct
    11821 gagctgtgac aagcaatggg agcgtcgttt tgattttttc aacatcccct tcgacgtccc
    11881 tttctgcttc tgcatcagtg ccgttgattt cgagtttggt gatcgtagtg atacatggaa
    11941 tgtccagtag ctcggcaagc cgaggcgcca cttgtcctga tcctccgtca atggcaacat
    12001 ttccgccgag aatcaaatca aactcctgat ccttcatata gtggtataaa acttgagaaa
    12061 tggaatattg gtcgggttct tcaagatcat cttctatgtt gattaaaaca gcttggtcac
    12121 aacccatggc aagcgccgta cgcaattctt tctccgcttc ttcaccgccg accgtgacgg
    12181 cggtgatcgt gccgccatgc ttttccttca gctggatggc ttcttctatc gcgtactcat
    12241 catatggatt aataatccat tccgctccgt catcctgaat ctttcctgtt tcaatgacga
    12301 ttttttcttc tgtgtcaaac gtccgtttca tcagtacaaa tagattcatg atcatatccc
    12361 cttttattcg cctttgaact gaggctttct tttttcgaga aatgcctgga tgccttcctt
    12421 ggcgtcctct gactcaaatg cttccccaaa tcgctttgct tcaagcttta agctgccttc
    12481 ataggaatac accttgttgg aataaagaag ttcaagcaaa gatgccagcg tttgtgggct
    12541 tttctctgca aacttagcgg caagtgcttt tgctttttca atcacttctg cctcatcttt
    12601 cgctccaatt gagacaagtc cgagatcaag cgcttctttt ccggatatcg gttctcctga
    12661 tccgataagc tctaatgctt tggctgtacc gacatatctc ggaaggcgct gtgtccccgc
    12721 aaaacctgga atgataccga gattaagctc cgggagcccc agcttagcat cttctgttgc
    12781 gattctgata tgacaggcca tcgcaagctc cagcccgcct ccgagagcag cgccgtgaat
    12841 cgctgcgata atcggttttg gaaagctttc gattctctcc attaactgct ggccgcgctc
    12901 agcgagcaat gaggaatcct cattgccttt aagcgatgta aattctttaa tatcagcgcc
    12961 ggctgagaaa aatcttccct cgccgtgaat gataatgctt cgaacgcctg catctatctc
    13021 acattgatca agacaggaag acagctcttc taatatccgg ctggaaagcg catttgccgg
    13081 cggattgtga atcgccaaaa ctgccacaaa ttgatcaact gccagtgata ttgcattcat
    13141 aggacagaac tcctttactt attatgaatt ccggacacca ataattctaa aacgctgtct
    13201 gaaagcgcag caagatcgta cttttggtca ttcatcaccc aagttgtcac ggtttcgtca
    13261 atcgttccaa aaatcatctg ccgggcgagg cg
//
