LOCUS       gnlProkkaKKGBGPNG_115  14793 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KKGBGPNG_115.
ACCESSION   gnlProkkaKKGBGPNG_115
VERSION     gnlProkkaKKGBGPNG_115
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:35:26
            Original ID  :: gnl|Prokka|KKGBGPNG_115
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14793
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14793
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10861:11962]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10862..11962
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..14793
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14793
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     CDS             3..674
                     /locus_tag="ctg109_1"
                     /transl_table=11
                     /translation="MEKGDQRSISFIQNAFSNASADFVKYTIQWLDRFIDFFGVAISGE
                     EYTTLYANLINIHLADSYFKGNSFFFSNDHSETEPDQLVDSFLDHLTTQVVWLDKNRKR
                     ELLDRYRFLLRNVLGFDGAVKPIKIKLYSIFGEAGKNVGLKMVQEVYPHLRFCEPGETP
                     DLIVSDRDYVTLKKEKANGAVVCILNVNNPAKQDYLRLENCIRVILKKNEAQPTVSNVI
                     H"
     CDS             complement(887..2341)
                     /locus_tag="ctg109_2"
                     /transl_table=11
                     /translation="MKESFLKALTFVLLSSLLLWPQAPAHAGFLGTGKPAPGAPPGTWV
                     VGDSPATTAGSPILFVHGLNSSALTWFEPNDMFVHTYEQGFPSAYINLHPDKSNWQNGE
                     LLAEKIRDIYHHFGEKVTVVAHSKGGVDTQTALLHYGAEPYVKEVITLGSPHHGSELAN
                     LAYSNWAGWLAEIIGQRSEGTDSLQTGNMAYFRAQTDALISAQSVPFSTISGTSWGSFG
                     SALYFGGLYLQFFGTNDGAVTVNSSRLSYAQELASNRWDHMQVAQGHLVFPLLQAQMGA
                     QAKKEEKTKSMSAAIVRGGQFNGNGSQAFVVEPNVKKAQISVLANEKLDSAELHSPDGK
                     VYHVAAVAAEQEHSVFYGAYAHHFEMDHPSAGEWELKMEHPQTTAYLAVIALEGGVSPA
                     IAFDSVRLQSDIDPNAIDVSKTRYTVHVNDDNIAANTASLHALPPQKDASQTITIDIEG
                     MTRNGDRFERTIITNRYVDKHGIIYE"
     CDS             2520..3194
                     /locus_tag="ctg109_3"
                     /transl_table=11
                     /translation="MIDWKPILIVVSVEPEKQAVLQGLGNSSAYEVLVGGVGMAQAAAR
                     TARQLTQKHYQGTINMGIAGGFPGKAANGTVAVATSIIAPEIGAESPGGFLTIDALGFG
                     TQTLPAVANDSYIGKLQEAVSVATGTILSVMTVTGTEATLNVRQSYGKDIVAEAMEGFG
                     VASAAAEFGLPFAEVRSISNQVGIRDKASWEFASAFSSLTKAAEKLKEVEQLGDCFFTM
                     SK"
     CDS             3163..3993
                     /locus_tag="ctg109_4"
                     /transl_table=11
                     /translation="MEIAFSPCPNDTFVFYAWVHGKIAGAPKLNVTYADIDRTNYWAID
                     QTGPEVMKISYAALPYVLDHYSLVPSGGALGRGCGPLVLTKEQQEAAALEGKTVAVPSD
                     RSTAYLLFRLWTEQNLPNNNIFIKVMPFDHIMPAVAKGEVDAGLVIHEARFTYETYGLS
                     LLQDLGEWWEQDTGFPIPLGAIIAKRSLDKEQLAKWARQSVEYAWAHPEETSDYVLSHA
                     QELSEEVANAHIELYVNEFTKSLGEDGYQAIENLLGRAMKQGLVPHFDVAKIRL"
     CDS             4048..4638
                     /locus_tag="ctg109_5"
                     /transl_table=11
                     /translation="MEKETATQYRQLALAMLRTGLFGFGGGPSVMPLFRVEAVDTYKWM
                     DNEEFGETLAIANTLPGPVATKMAAYLGYRLKGWTGACWATLWHILPTSVAMVLLFSLV
                     DAISGSEVVAGMIGAVTPVIAVLLAQMAYDFGKKAVKGFGWVFGILTFLIAFAALQGFD
                     VHPGFVIIAFIIYGVFHYKLVDKWRSRQKGESS"
     CDS             4635..5174
                     /locus_tag="ctg109_6"
                     /transl_table=11
                     /translation="MILLYLFIAFFLANLLGYGGGPASIPLMFEEVVNRYHWLTSDEFS
                     NVLALANALPGPIATKIAAYVGFAAGGWSGFIVAHAATIVPSALAMILLMRVLRKYRQS
                     KVVKGISLAVQPVICILMVVLTFDIIGDAAAEIGWLQSLAIAAVAFLLLTKAKVHPALV
                     IVASFVYGGLVIPFLG"
     CDS             5293..6048
                     /locus_tag="ctg109_7"
                     /transl_table=11
                     /translation="MFTLERHEKLLAYLAKHKSIRVSQASEWLGVTEKTIRLDLERLEE
                     KKLLKRVHGGAVLMETDTSLFPIQEREQRNEKEKHAIAEKAKSLICENDVILLDGGSTT
                     LALAERLGDKPMTVITNDIRIANALYEKEAIQLILLGGTRLGTSSALYSQQTTAMLKSL
                     YVQKVFLGATGVSLDHGLSILNSFHYEWKRAAINCGRKTILLSDSSKFGQVGLMRFADI
                     TEIDELVSDDLLDSETRSVLEEEYGINVY"
     CDS             6147..6899
                     /NRPS_PKS="Domain: PKS_KR (9-168). E-value: 7.3e-08. Score:
                     24.4. Matches aSDomain: nrpspksdomains_ctg109_8_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     215.8; E-value: 1.1e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_8"
                     /sec_met_domain="adh_short (E-value: 5.7e-33, bitscore:
                     104.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMFSLAGKTAVVTGASRGLGQGMALGLAEAGANIIGAGISEMTE
                     TKQKVEELGGRFYGIKADLSQPDGAKELAAKVLEHVESVDILVNNAGIIKRADANLLDD
                     AAWREVLHVNLDAVFTLSREIGAHMLEKGSGSIINVASMLSFQGGLRVAAYTASKHAVA
                     GLTKALANEWAKKGVRVNAIAPGYMVTDNTEGIRTDESRYAYISSRIPKGEWGLPDDLK
                     GPVVFLASEASNYVNGHILAVDGGWLSA"
     aSDomain        6174..6650
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg109_8_PKS_KR.1"
                     /evalue="7.30E-08"
                     /label="ctg109_8_PKS_KR.1"
                     /locus_tag="ctg109_8"
                     /protein_end="168"
                     /protein_start="9"
                     /score="24.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGASRGLGQGMALGLAEAGANIIGAGISEMTETKQKVEELG
                     GRFYGIKADLSQPDGAKELAAKVLEHVESVDILVNNAGIIKRADANLLDDAAWREVLHV
                     NLDAVFTLSREIGAHMLEKGSGSIINVASMLSFQGGLRVAAYTASKHAVAGLTKA"
     CDS_motif       6180..6245
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg109_8_0001"
                     /evalue="3.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg109_8"
                     /protein_end="33"
                     /protein_start="11"
                     /score="10.1"
                     /tool="antismash"
                     /translation="VVTGASRGLGQGMALGLAEAGA"
     CDS             6950..7780
                     /locus_tag="ctg109_9"
                     /transl_table=11
                     /translation="MDIRYEVGPRDFKTYTTEEIRKAFLVESLFEEGTLHLSYSHYDRL
                     IIGGAVPSREAIALDAGDALKTDYFLERRELAVINIGGEGTVTVGKDTYKMAKRDCLYV
                     GKGNEHVEFASNDPQQPARFYLVSATAHQTYPTKLAPIGEAQPTKLGSDAESNNRTIYK
                     YVHKDGIESCQLMVGMTLLEPNNMWNTMPAHLHDRRMEAYLYFDMEEDTRVFHFMGQPQ
                     ETRHLVIKNEQAVISPPWSIHSGVGTSNYTFIWAMAGENYTFTDMDTVAMEELK"
     CDS             7781..9199
                     /locus_tag="ctg109_10"
                     /transl_table=11
                     /translation="MISTGKAFIHENFMLQNKTAETLYHTYAKTLPIIDYHCHVPPQEI
                     AENRQFNNISEIWLHGDHYKWRAMRAVGVEETFITGDGDDKEKFLKWAETVPYTMGNPL
                     YHWTHLELKRYFGIDELLSSDTAEAIWRATKEQLAERERSVQGIIKESNVEVICTTDDP
                     SDHLEDHQQIRKDGACQAAVYPAFRPDKALFASAPSFVSYLETLGAAAEVDISSLRSLL
                     EALEKRATFFAEEGCVLSDHGLRTLPFVDATEKEAEAAFQKALNQETLTPQEEEKYQTY
                     VLLFLARLYNKLGWTMQFHLGALRNNNSRMAEQVGPDSGFDSMGDDRFAESLNRFLNEL
                     ERTNELPKTILYTLNPIYNEVIATAIGNFQGGGIPGKIQFGSGWWFNDTKDGMEKQMTD
                     LANNGLLSLFVGMLTDSRSFLSYTRHEYFRRILCNRIGEWVERGEWPADEKWLGKVVED
                     ISYYNAKRYFAFPK"
     CDS             complement(9156..9782)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 134.9;
                     E-value: 4.6e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_11"
                     /transl_table=11
                     /translation="MYRPHLQASTELLTKRLFLRLPLPGDGFALYQALQASKKELVPWI
                     PWVERMSSPEQAEQGVQQAHVDFLQKKAFHFHLFEQRSGTFVGSCGLHHINWDVPRMEM
                     GYWIDSRFAGKGYMTEAAKALMFYAFFTHDTHRLEIRCDRNNKKSRAIPEKLGFMLEAT
                     LLENERSPHTGELMDTCIYTAFHPSVSRPPESISGKQNSALHYNN"
     CDS             complement(9942..10697)
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     124.7; E-value: 9.3e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg109_12"
                     /transl_table=11
                     /translation="MEYTVKKLAQLAGVSARTLRYYDEIGLLKPERVNSSGYRIYGPKQ
                     VDLLQQILFYRELDVDLETIMQLVTDDSFDPVKALYEHRAHLLNKRARLDRIIDTVERT
                     IASKKGAETMSDKDKFDALKEKRIADNEKAYGEEIRQKYGDKTVEESNAKFRGLSKEQY
                     DAMQAKEQEVFALLKEALATNDPTSETARKLAQTHKEWLQFSWASYSKEAHAGVAKMYV
                     DDERFAAYYNKAVPGGAIFLRDAILAYLQ"
     CDS             10862..11962
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_C"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:chalcone and stilbene synthase domain protein
                     (Score: 416.3; E-value: 1.3e-126)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_13"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 3.4e-25,
                     bitscore: 79.1, seeds: 21, tool: rule-based-clusters)"
                     /sec_met_domain="Chal_sti_synt_C (E-value: 1.8e-25,
                     bitscore: 80.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTILSVSTYDPPHPLKQEQTVEFARELFAESFSDIERLLNVFAN
                     GEIEKRHFSVPLEWFQTSHRLGERNDLFIEKATDYSVEAVKSCLANGHFLSRTIAPEEI
                     DAIIFVSSSGMATPSIDARIMNKLPFRPETKRLPIWGLGCAGGAAGLSRAYDYCLAHPE
                     TAVLVVCAELCGLTFQKEDQSKSNLIGTSLFADGVACALVAGHASPLLADAAQAYRPVI
                     RATQSVLMPDSEDVMGWDVRDNGLNVIFSRHIPTLVAQWLKPNVEELLRQEGKEIGEIN
                     AFIAHPGGKKVLEAYEKALGFPEEMTMLSRKVLKEHGNMSSPTVLYVLKESMEETHKHG
                     DVGLVAALGPGFCSEMLVLEWAGGLH"
     CDS             11959..12510
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1150:isoprenylcysteine carboxyl methyltransferase
                     (Score: 219.2; E-value: 5e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_14"
                     /transl_table=11
                     /translation="MTWAYMMIALIIIQRLVEVRVARRNERWLKAQGGVEAGTAHYPWM
                     VTLHCGFFISLLIEVTVSNIAFSRWSAIPLAIVVIAQIIRIWALSSLGKYWNTKIIVLP
                     EAPVIEKGPYRFLRHPNYMVVVAEIAFVPLLFQAYWTAIVFSLLNAVMLTIRIPTEEAA
                     LQGETDYGERFKEKKRFWLV"
     CDS             complement(12619..12735)
                     /locus_tag="ctg109_15"
                     /transl_table=11
                     /translation="MIKTVLLLTILFFAFNAQTAFISTYENVNTSVKPGQAV"
     CDS             complement(12732..13766)
                     /locus_tag="ctg109_16"
                     /transl_table=11
                     /translation="MKDLANNHPELSFEQVLTMVKKTLPNDYVPLMNIYALHVKKLRHV
                     QDAFEYANLFRQVDLLDKMIDTHKTDELLEDWVEVYRLFSKFLKQEVNADNFIHEAKIL
                     YGKTQNNQLRMRLDIAQLNYYDILGSINNQKPLIEQFKSQFAVMESGFLKSALAIRVTL
                     LAGNAYLFGDGDFETAEGYYLAASVVDSIPDALLVTSYHGLGLIYLKDDKQRCLEAHEK
                     ALFYSRRAKIIDYEKKLLYDYIPFVKNMLGETFEIKNVVPKEQAHQYVIRGEMNKALEI
                     INELELKGNTSKAHLLFYKAKATKSVPLFFKSIQAFSAEGYTHMIEYVLKEINKIKPFK
                     GDIL"
     CDS             14115..14498
                     /locus_tag="ctg109_17"
                     /transl_table=11
                     /translation="MGDQREIAKLHHEISQMRAQLFQTEAQLERLRAAKQALVSEQATL
                     HDHKKWGSEPELDHDAWRGQAESTHDDIRRHMQLAYTNVQDETEQLMRAIEMETRRLQT
                     TIASCQIVIDTKQQSLQTLKAAK"
     CDS             14517..14780
                     /locus_tag="ctg109_18"
                     /transl_table=11
                     /translation="MPEIKIDEGSVLSALSETGEQASYSVSGHEPAIHTSSMAFLHSLL
                     EVESGYADQFNRYLDVVKNVQAETKELVQTYGVVDKMLASRG"
ORIGIN
        1 atttagaaaa aggcgaccaa cgttccattt cttttatcca aaatgctttt tccaacgctt
       61 ctgctgattt tgtcaaatac accatacaat ggttggatcg ttttattgat ttttttggcg
      121 tcgcgattag tggcgaagaa tatacaacac tatatgctaa cttaatcaac attcatttgg
      181 cagacagtta ttttaaaggt aattcctttt ttttcagcaa cgaccattct gaaacagagc
      241 ctgaccaatt ggttgactcg tttctggatc atttgaccac acaagtggtt tggttagata
      301 aaaatagaaa acgagaattg ttagataggt atcgattttt attaagaaat gtactgggtt
      361 ttgatggtgc agtaaaaccc attaaaataa agttgtattc catttttggc gaagcaggaa
      421 aaaacgtagg tttaaaaatg gtgcaagaag tttatcccca cttgcgtttt tgtgagccag
      481 gggaaacgcc agatttgatt gtttcagacc gcgattatgt aacgctaaaa aaagaaaagg
      541 caaacggagc ggtcgtctgt atattgaatg tgaacaatcc ggcgaaacaa gattatttaa
      601 ggttggaaaa ttgtattaga gtaatattaa aaaagaacga ggcgcaaccg acagtaagca
      661 atgttattca ttgagagaag ccgctgccag ttacgtttcg taaataaggt tcctttttcg
      721 atatcgaaaa aggaaccagc aacgattatt gggtatttgt caattcaatg ttttagtgga
      781 ccagctgctt tggtatgatt cctttttgtt gttgcggaat tacagacaat tgatcgtatt
      841 cttcctaatt ttagtccgct cctaaattgc cggcgccatc tgtcgatcat tcataaataa
      901 tgccatgctt gtcgacatag cggttggtaa tgatcgtccg ttcaaagcga tcgccgtttc
      961 ttgtcattcc ttcaatatca atggtaatcg tttgcgaagc atctttttgg ggcggcagcg
     1021 cgtggagcga agctgtattg gctgcgatat tgtcatcatt gacatggacg gtgtagcgtg
     1081 ttttgctgac atcgatggca ttcgggtcaa tgtcagactg gaggcgaacg ctgtcaaaag
     1141 cgatggctgg cgaaacgccg ccttcaagtg cgataaccgc taaataggct gttgtttgcg
     1201 ggtgttccat ttttaattcc cattccccgg cactcgggtg gtccatttca aaatgatgag
     1261 cataagctcc gtaaaaaaca ctatgctctt gctcggcagc gacggcggca acatgataga
     1321 ctttcccatc tggagagtga agttcagcgg agtcgagctt ttcatttgca agcaccgaaa
     1381 tttgtgcttt ttttacgttt ggttcgacga caaacgcctg gctgccattt ccgttaaatt
     1441 ggccgccacg gactatagct gcgctcatgg actttgtctt ctcttctttc ttagcctgtg
     1501 cacccatttg cgcttgcagc aaagggaaaa caaggtgtcc ttgcgccact tgcatatgat
     1561 cccaacggtt ggaagcaagt tcttgtgcgt agcttagtct agagctattt actgtcacag
     1621 ccccatcatt agtgccgaaa aattgcaaat acaatccgcc aaaatagaga gcagatccaa
     1681 acgagcccca ggatgttcct gaaatcgtcg aaaaggggac agattgtgca gagattaaag
     1741 cgtctgtttg cgctcgaaaa taggccatgt tccctgtttg caaagagtct gtgccttctg
     1801 agcgttggcc gatgatttcc gcgagccagc cagcccagtt gctgtatgct aagttggcaa
     1861 gttcgcttcc gtggtgaggc gaaccgagcg taatgacttc ttttacataa ggttcagctc
     1921 cgtaatgtag gagcgcagtt tgcgtatcga cgccgccttt gctatgagca acaactgtga
     1981 ccttttcacc gaaatggtga taaatatcgc gaattttttc cgctagcaac tcgccatttt
     2041 gccagtttga tttatcaggg tgcaaattga tgtaggcgct cggaaatcct tgctcatatg
     2101 tgtgtacgaa catgtcattt ggctcgaacc aagtgagtgc ggaactatta aggccatgga
     2161 caaacaaaat cggcgatcca gcagtcgtag ctggcgaatc accaacaacc caggttcctg
     2221 gcggagcgcc aggggctggt tttcctgtgc caagaaaccc agcgtgtgct ggagcttgcg
     2281 gccataaaag cagggaagac aacaaaacaa aagtaagcgc tttcaaaaat gattctttca
     2341 tccaaattca ctccttattt gtcagataat acattctatg aatgattcct tgccgcatgt
     2401 ataggtaata gaagtgattg ttatattgaa caggcttgaa agcaaacaaa tggactttgt
     2461 tggcaacttc atttatggta tactagaccg ttagaattgt tggaaaggat tgttggcgcg
     2521 tgatagactg gaagcctatt ttgattgtcg tttccgtgga acctgaaaaa caggctgtct
     2581 tacaagggtt gggaaattct tcagcctatg aagtacttgt gggcggtgta ggaatggccc
     2641 aagcagctgc acgtacagca aggcagctca cccaaaaaca ctatcaagga acgataaata
     2701 tggggattgc tggtggtttc ccgggaaaag cggcaaatgg cacggttgct gtcgcaacgt
     2761 cgattattgc cccggaaata ggggcagagt cacctggagg gtttttgacg attgatgcgc
     2821 tcggttttgg tacacaaaca ttgcctgcag ttgcaaacga ttcttatatt gggaaacttc
     2881 aagaagccgt atctgtagca actggcacaa ttttgtccgt gatgaccgtg actgggacag
     2941 aagcgacatt aaacgtccgc caatcctatg ggaaagatat agtggcggaa gcgatggaag
     3001 ggtttggagt agccagtgca gcggcggagt ttggcttgcc ttttgccgaa gtaaggtcta
     3061 tttcaaacca agtaggcatt cgcgataaag caagctggga atttgcgagt gctttttcgt
     3121 cgttgacaaa agcagcagag aaattgaagg aggttgaaca acttggagat tgctttttca
     3181 ccatgtccaa atgacacatt tgtcttttat gcatgggttc acggaaagat tgctggtgcc
     3241 cctaagttaa atgtaaccta tgccgatatt gaccgcacca actactgggc gattgatcag
     3301 acggggcctg aagtcatgaa aatttcttat gctgcgttgc cgtatgtact cgaccattat
     3361 agtctagtgc cgagcggagg cgctcttggt cgtgggtgcg gacctcttgt gttaacgaaa
     3421 gaacagcaag aagcagctgc tcttgaaggg aaaacggttg ctgtgccaag tgaccgctca
     3481 actgcatact tattgttccg tctctggact gaacaaaatt tgcctaataa taacatcttt
     3541 ataaaagtga tgccatttga ccatattatg cctgcagtcg caaaaggaga agtcgatgca
     3601 gggctcgtca tccacgaagc acgttttaca tacgaaacgt atggactctc cctgttgcaa
     3661 gatctaggcg aatggtggga acaagataca ggttttccga tcccgttagg cgcgattatt
     3721 gccaagcgct ctctcgataa agagcaattg gccaagtggg cccgacaatc ggttgagtat
     3781 gcatgggcac accctgagga gacaagcgac tatgtgcttt cacatgccca ggagctttca
     3841 gaagaagtcg ccaatgctca tattgaactt tacgtaaatg agtttacgaa gtcacttgga
     3901 gaagatggct atcaagcgat tgagaacttg ttaggccgtg cgatgaaaca agggcttgtc
     3961 cctcactttg acgtcgctaa aattcggtta tagcgctaag tggagctttg taaactagaa
     4021 tgaatagaga aaagagggat aacagcagtg gagaaggaga ccgcaacgca atataggcag
     4081 ctagcactgg cgatgctgcg gacagggctg tttgggtttg gcggcggccc gtcagtcatg
     4141 ccactgtttc gggtggaagc tgttgatacg tataaatgga tggacaatga agaatttggc
     4201 gagacgctgg cgattgctaa tacgttgcca ggaccagtgg caacgaaaat ggcagcctat
     4261 ttaggttatc gattgaaggg ctggactggc gcttgctggg caacgttgtg gcacattttg
     4321 cctacgagtg tagcgatggt gttgcttttt tcgcttgttg atgccattag tggctctgaa
     4381 gtggttgctg gcatgatagg tgcagttaca cctgttatcg ctgttttgct cgcgcaaatg
     4441 gcgtatgatt ttggcaagaa ggcggttaaa ggtttcggct gggtttttgg cattctcact
     4501 tttctcattg cctttgccgc tttgcaaggg tttgacgtcc accctggctt tgtgattatt
     4561 gccttcatta tttacggtgt atttcattat aaactggtgg ataaatggcg gagcaggcaa
     4621 aaaggagagt cgtcatgatt ttattatatt tatttatcgc attttttctt gctaacttgc
     4681 taggctatgg gggtggcccg gcttccattc cgcttatgtt tgaagaagtt gtcaaccgct
     4741 atcactggtt gacgagcgat gagttttcca atgtccttgc cttggcaaat gctctgccag
     4801 ggccgatcgc aacaaaaatt gctgcatatg ttggatttgc tgccgggggc tggtcaggtt
     4861 ttatcgttgc ccatgcagcg accattgttc catcagcgct ggccatgatt ttgttgatgc
     4921 gtgttttgcg aaagtaccgc cagtcaaagg tggtcaaagg catttccctt gctgttcaac
     4981 ctgttatttg catattgatg gtagtgttga cattcgatat cattggcgat gccgctgccg
     5041 aaattgggtg gcttcagtca ttggcaattg cagcggttgc ttttctgcta ttgacgaagg
     5101 caaaagtcca tccagcatta gtgattgtcg cctcatttgt ttacggcggt cttgtcattc
     5161 catttctagg ataggcagtt aacgagggag tcggtatgag tgtatacaca caggcagttt
     5221 cataaaaagc tgcctgtttt tatgtttatt tatgttcggt tatgtgtgat aatggaacag
     5281 aggtgaagaa tcatgttcac attggaacgg cacgaaaaac tgcttgccta tttagcgaaa
     5341 cataaatcga tacgcgtttc ccaagcgagc gaatggcttg gtgttacaga aaaaacaatt
     5401 cgcttagatt tagagcggct tgaagaaaaa aagctgctta agcgtgttca tggcggtgcc
     5461 gtattaatgg aaaccgacac aagcttgttt ccgattcagg agcgggagca aagaaatgaa
     5521 aaggaaaagc acgctattgc ggaaaaagca aaatcgttga tttgtgagaa tgacgtgatt
     5581 ttgctggatg gcggcagcac gacgctggcc cttgctgagc gccttggcga caagccaatg
     5641 acggtcatta ctaatgacat ccggatcgcg aacgcccttt atgaaaaaga agcaattcag
     5701 cttattttgc tcggaggaac acgacttggc acttcttcgg cactgtatag ccagcaaacg
     5761 acggcgatgc tcaagtcgtt gtatgtgcaa aaagtatttt taggggcgac tggcgtctct
     5821 cttgatcacg gcttatcgat actaaacagc tttcactatg aatggaaaag agcggcaatc
     5881 aattgcgggc gaaaaacgat cttgctgtct gattcaagca agtttggcca agttggttta
     5941 atgcgatttg cagacataac agaaattgac gaacttgtca gcgatgactt gttagacagt
     6001 gaaacacgaa gcgtcttgga ggaagaatac ggcatcaacg tttattaaca agtgcagtaa
     6061 aaaacgctgc ctagttgtaa gcggtttaaa gctatggtat gatcaaacgt aaatgaacca
     6121 aaacaaacat ataaggggga atggggatga agatgttttc gcttgcagga aaaacagccg
     6181 tcgtcactgg cgctagccga gggcttggcc aagggatggc gctcggactt gccgaggcgg
     6241 gtgctaacat cattggagca ggcattagcg agatgacgga aacaaaacaa aaagtagagg
     6301 aactcggcgg gcgcttttat gggataaaag ccgatttatc tcagcctgat ggggcaaaag
     6361 aattggccgc taaagtttta gaacatgttg aaagcgttga catcttggtc aataatgccg
     6421 gcatcattaa gcgggctgat gcaaacttgt tggatgatgc agcttggcgg gaagtgctgc
     6481 acgtcaattt ggatgctgta tttacgttgt ctcgggaaat tggcgcacat atgcttgaaa
     6541 agggatcagg atcgatcatt aacgtggcct cgatgctgtc gttccaaggc ggattgcgcg
     6601 ttgccgccta tacagcaagc aaacatgccg ttgctggttt gacgaaagca cttgccaatg
     6661 agtgggccaa aaaaggggtg cgcgtcaatg cgattgcccc agggtatatg gtaacagaca
     6721 atacagaagg gattcgtaca gatgaaagcc gttatgctta cattagctcg cgaattccga
     6781 aaggcgaatg ggggctccct gatgatttga aaggtcctgt tgtttttctc gcatcggagg
     6841 cgtcaaacta tgtgaatggc catattctag cagtcgatgg cggttggtta agtgcataaa
     6901 cgaaccattg tgactctaac aaacgaaaac gtgaaaaggg gaaatggaaa tggatattcg
     6961 ttatgaagta gggccaagag attttaaaac gtatacaaca gaggaaataa gaaaagcttt
     7021 cttagtcgaa tcgctgtttg aagagggtac gctccattta agctactccc actatgaccg
     7081 attaattatc ggcggcgctg ttccaagccg tgaagcgatt gccctagacg caggcgatgc
     7141 tttaaaaacc gattattttc ttgaaaggcg ggagttggct gttatcaata tcggtggcga
     7201 agggacggta acggtcggaa aagacacata taaaatggca aagcgtgact gcctctatgt
     7261 cgggaaaggc aatgaacatg tcgaattcgc aagcaacgat ccacaacaac cagcccgatt
     7321 ttatttagtg tcagccactg cccatcaaac atatccgaca aaactggcac cgattggaga
     7381 agcgcaaccg acgaaattag gttcagatgc tgaatcgaat aaccggacga tttacaagta
     7441 tgttcataaa gacgggattg aaagctgcca gttaatggtg ggaatgacgc tgcttgagcc
     7501 gaacaatatg tggaatacaa tgcctgccca cctccatgac aggcggatgg aagcctattt
     7561 gtattttgat atggaagaag atacgcgtgt gttccacttt atgggtcagc cgcaggaaac
     7621 gcgccatcta gtgatcaaaa atgaacaggc tgtcatttca ccgccatggt caattcattc
     7681 aggcgtcggc acaagcaatt acacatttat ttgggcgatg gctggcgaaa attacacgtt
     7741 tacggatatg gacacagtag cgatggagga gctgaaataa atgatttcca caggaaaagc
     7801 attcattcac gaaaatttta tgctgcaaaa taaaacagca gaaacacttt accatacgta
     7861 tgcaaaaacg ttgccgatta tcgactacca ttgccatgtc cctccacaag aaattgccga
     7921 aaaccgccaa tttaacaaca ttagcgaaat ttggcttcac ggcgaccatt acaaatggcg
     7981 ggcaatgcgt gctgtcggtg tcgaagaaac gtttattaca ggcgatgggg atgacaaaga
     8041 gaagtttctt aaatgggcgg aaacggtccc ttatacaatg ggcaatcctc tctaccactg
     8101 gacgcacttg gaattgaaac gttattttgg cattgacgag ctgttaagca gtgatacagc
     8161 tgaagccatc tggagggcca cgaaagaaca actggcagaa cgagagcggt cagtccaagg
     8221 catcatcaag gaatcgaatg tcgaagtgat ttgcacaaca gacgatccga gcgaccattt
     8281 agaagaccat cagcaaatta gaaaagatgg agcgtgccaa gcagcggtgt accctgcatt
     8341 tcgccctgac aaagccttgt ttgcttcagc gcctagcttt gtctcttatt tagaaacgtt
     8401 aggggctgcg gcagaagtgg acatttcatc gcttcgctct ttattggagg cactggaaaa
     8461 acgggcgacg ttctttgccg aggaaggctg tgttctttct gaccatgggc ttcgtacact
     8521 cccgtttgta gatgcgaccg aaaaagaagc agaagcggcg tttcaaaaag cactaaacca
     8581 agaaacgctt acgccgcaag aggaagaaaa ataccaaaca tacgtattgt tgtttttggc
     8641 acgtctgtac aacaaactcg gctggaccat gcaatttcat ctaggggcat tgcgaaacaa
     8701 taattcgcgg atggctgagc aagttggacc agactcaggt tttgactcta tgggtgatga
     8761 ccgttttgct gaatcattaa accgtttttt aaacgagcta gagcggacaa atgagctgcc
     8821 aaagacgatt ttgtatacat tgaacccgat ttataacgag gtgatcgcga ctgcgattgg
     8881 caacttccaa ggaggcggca tacctggcaa aatccaattc ggttcaggct ggtggtttaa
     8941 cgatacgaaa gatggcatgg aaaaacaaat gacggacttg gcaaacaatg gtttgttaag
     9001 cttgtttgtc ggtatgctta cggattcccg cagcttcctt tcctacacgc gccacgaata
     9061 ttttcgtcgc attctgtgca atcgtatcgg tgaatgggtt gagcggggcg aatggccagc
     9121 ggacgaaaaa tggctcggca aagtggtaga agacattagt tattataatg caaagcgcta
     9181 ttttgctttc ccgaaataga ctcaggtggc cgggagacag acggatgaaa agccgtataa
     9241 atgcacgtat ccatcagttc tcccgtatgt gggctccgtt cgttttctag caatgtcgct
     9301 tcaagcataa agccgagctt ctcaggaatc gctcggcttt ttttgttgtt tcgatcacag
     9361 cgaatttcca ggcggtgagt atcgtgtgta aagaaggcat agaacataag tgctttagcc
     9421 gcttcagtca tatagccttt tccagcaaaa cggctatcga tccaataccc catttccata
     9481 cgcgggacat cccagttaat atggtggagt ccgcaggagc cgacaaaagt accggaacgc
     9541 tgctcaaata agtggaaatg aaacgctttt ttttgcaaaa aatcaacatg tgcttgctgt
     9601 acaccttgtt cagcttgctc tggcgatgac attctctcca cccatggaat ccatggcacc
     9661 aattcttttt tggaagcctg gagcgcttga tacaaagcaa acccgtcgcc aggcagtggc
     9721 agcctcagga ataaccgttt agtcaaaagc tcagttgacg cttgcaaatg gggccgatac
     9781 atcaaaacgc ctcttttcct ttcatatgga atccagcatt agttcaatgt atgggaaaaa
     9841 aggctggttt atgaataatg gcgcgcagct tggaggagca agcttactag gaataaccca
     9901 gttgaagaga acttcaaact gggttgcatc aatacgtcaa attattgaag ataagccaat
     9961 atagcatcgc gcaagaagat ggcgcctcca gggactgctt tgttgtagta agcagcaaag
    10021 cgctcatcat ctacatacat tttggcaacg ccagcatgtg cctctttcga gtaagacgcc
    10081 cacgagaact ggagccactc tttatgggtc tgggctagtt ttcgggctgt ttcagacgta
    10141 gggtcgttcg ttgccagtgc ttcttttaac aaggcaaaga cttcctgttc ttttgcttgc
    10201 atggcgtcgt attgctcttt cgagagacca cgaaatttgg catttgactc ctcaaccgtc
    10261 ttgtcaccgt atttttggcg tatttcttct ccatacgctt tttcattgtc tgcaattcgc
    10321 ttttctttca aagcgtcaaa tttgtctttg tcactcatcg tttctgctcc tttctttgag
    10381 gcaatcgtcc gctcaaccgt gtcgataatg cggtcaagac gggcgcgttt attcaggagg
    10441 tgggcacggt gctcataaag cgccttgaca ggatcaaagg aatcgtcggt cacgagctgc
    10501 ataatcgttt caaggtcaac gtcaagctca cggtaaaata aaatttgctg caacaggtcg
    10561 acttgttttg gcccatatat ccgataacct gatgaattga ctcgttctgg cttaagcaaa
    10621 ccaatttcat cataataacg aagcgtccgt gcactgacgc ctgctaattg agccagtttt
    10681 ttgaccgtat actccatttc aactcccccc ttgagttaac aataaacgtt tacgtaacgt
    10741 taatgtcaat acacaaataa aatctttttt tcttacgttt agatttcctc catagaaggg
    10801 atgcatgcac aaggaaagcg tagggcatgc tataagcatt ctaacgtaga ggtgagcgat
    10861 cgtgcctacg attttatcag ttagtacata tgatccacca catccactta aacaagaaca
    10921 aacggttgaa tttgcccggg aattatttgc agaaagtttt tccgacatcg aacggttatt
    10981 aaacgttttt gctaatgggg aaattgaaaa gcgccatttt tccgtgccat tggaatggtt
    11041 ccaaacaagc caccgtctag gagagcggaa cgacctcttc attgaaaaag caacggacta
    11101 tagtgtagaa gcagtaaaaa gctgcttggc aaatggccat tttttatcaa gaacaatcgc
    11161 tcccgaagaa atcgatgcga ttatttttgt gtcctcgtca ggcatggcaa cgccatcgat
    11221 agacgctcgc atcatgaaca aactgccttt ccgtcctgaa acaaaacggt tgcctatttg
    11281 gggacttggc tgcgcgggag gagctgcggg cttaagccgc gcttacgact attgtctcgc
    11341 ccatcccgaa acagccgttt tagtcgtttg tgccgagcta tgtggactaa ctttccaaaa
    11401 agaagatcaa tcgaaaagca atttaatcgg cacgtcgctt tttgccgatg gcgtcgcatg
    11461 tgcccttgtc gctgggcatg cctcgcctct gctcgcagac gccgcccaag cctatcgccc
    11521 agtaatccgt gcgacccaat cggtactgat gcctgactca gaagatgtca tgggctggga
    11581 tgtacgggac aatggattaa atgttatctt ttcaaggcat attccaacat tagttgccca
    11641 atggctgaag ccgaacgttg aggagctgct tcgccaagaa gggaaagaga taggggagat
    11701 caatgctttt atcgcccatc ctggcggaaa aaaagtgttg gaagcgtatg aaaaagcact
    11761 aggttttcca gaagaaatga cgatgctttc ccgcaaagtg ttaaaagagc acggcaatat
    11821 gtcttccccc actgtccttt acgtgctaaa ggaatcaatg gaagaaacac acaagcacgg
    11881 cgatgtcggc ctcgttgcgg cgctcggccc tggattttgt tcagaaatgt tagtgcttga
    11941 atgggcaggt ggcctccatt gacgtgggcc tatatgatga ttgcgctgat tatcattcaa
    12001 cgcctcgtgg aagtaagggt agcgagacga aacgaacgtt ggctgaaagc acaagggggc
    12061 gttgaagcgg ggacagccca ctatccatgg atggttacgc tgcattgtgg tttttttatt
    12121 tcactactga ttgaagtgac ggtatccaat atagcatttt cgcgttggag cgcgattccc
    12181 cttgccatcg tcgtcattgc ccaaatcata cgcatctggg cgctttcctc cctcggtaaa
    12241 tattggaaca cgaaaattat tgtgttgcca gaagcgccag tcattgaaaa agggccatat
    12301 cgctttttgc gccatcctaa ttacatggtt gtagtggcgg aaatcgcgtt tgtcccattg
    12361 ctgtttcaag cgtattggac ggctattgtg tttagtctat taaatgcggt catgctgacg
    12421 atccggattc ccacggaaga ggcagccttg caaggagaga cagactacgg cgaacgattt
    12481 aaggagaaga agcggttttg gttggtgtga gaggaaataa taaaaaataa tatgctttct
    12541 tggaggtgag gttaaccaaa aaatttcccc agaatatttt ctggggttct tctatctatt
    12601 cgaaaatatt tgagattatt aaacagcttg tccaggtttt acactagtat tcacattctc
    12661 atatgttgat ataaaagcgg tctgagcatt aaaggcaaag aacaggatcg tcagcagcag
    12721 tacagtttta atcataatat gtctccttta aatggtttta ttttatttat ctcttttaaa
    12781 acatattcaa tcatgtgagt ataaccttct gcactgaaag cttggatcga tttaaaaaat
    12841 aaagggacac tttttgttgc ctttgctttg taaaataata aatgagcttt ggacgtattt
    12901 ccttttaact ctaattcatt aataatctca agagctttat tcatttcacc tcgtatcaca
    12961 tattgatgag cttgttcttt aggtactaca tttttgattt cgaaagtttc tcccagcatg
    13021 ttcttgacaa acggaatgta gtcataaagc aatttttttt cataatcgat tatttttgcc
    13081 cttcttgaat aaaacaaagc cttttcgtgt gcttctaaac atctctgttt atcatcttta
    13141 agataaatta aaccgagtcc atggtatgaa gtgactagca gtgcatcggg aatggagtca
    13201 acaacactcg ccgctaaata ataaccttca gctgtttcaa agtccccgtc gccaaataaa
    13261 taagcatttc ctgccaaaag cgttactcta atagctaaag cacttttcaa aaaaccgctc
    13321 tccattactg caaattggct tttgaattgc tcaataagtg gcttttggtt atttatactt
    13381 ccgagaatgt catagtaatt cagctgtgca atatcaagtc tcattcttaa ttggttattt
    13441 tgggtttttc cgtacaatat ttttgcttca tgtataaagt tatcggcatt cacctcttgt
    13501 tttaaaaatt tggagaataa acgatatact tcaacccaat cctcaagtag ttcgtctgtt
    13561 ttatgtgtat cgatcatttt atctagaagg tcaacttgtc taaacaaatt cgcatactca
    13621 aatgcatctt gcacatgacg gagtttttta acgtgtaagg cgtaaatatt cattaaagga
    13681 acgtaatcat tcggcagcgt ttttttcacc attgtcaaca cttgttcaaa tgaaagttct
    13741 ggatggttgt ttgcgaggtc tttcatcaat tgtgctgtaa tttgttcttt ctgcaatata
    13801 ccgttattgg caattgcaac tacaggttgt tgaatgtttt cccctccttt tttggttggg
    13861 cttatttaaa ggatagtaca gcaaatgaca caaatcaaca actttctgct aatttttgat
    13921 tttcccaata cgcagctagt taatttttgt cgtttctgaa gaaaaaacga ggaatacagt
    13981 tctttttgtc ttttgagggg gagaaatgat ttgctttttc tagacgattt cgaacagttg
    14041 ttttaaaata aaatggaatg aatagccatt ttttttagac ggaagaatga aaccaccagg
    14101 ggggaggatg gcctatgggc gatcagagag aaatagccaa gctccaccat gaaattagcc
    14161 agatgcgggc gcaacttttt cagacagaag cgcaattgga gcgattgcgg gcggccaaac
    14221 aagcgcttgt ttccgaacaa gcgactcttc acgaccataa aaaatggggg agcgaaccag
    14281 agctagacca tgatgcgtgg cgcggccaag ccgaatcgac gcacgatgac attcgccgcc
    14341 atatgcaact ggcttacaca aacgtacaag acgaaacgga acaactgatg cgcgcgattg
    14401 aaatggaaac gaggcggctc caaaccacga ttgcctcttg ccaaatcgtg atcgacacaa
    14461 agcaacaatc gctccaaaca ttaaaagcgg cgaaatagga aaggaggaga gaactgatgc
    14521 cggaaatcaa aatcgacgaa ggctccgtgc tcagcgcttt aagcgaaacc ggggaacagg
    14581 ccagctattc tgtgtcaggc cacgagcctg cgatccatac gtcgtcgatg gcctttctcc
    14641 attcattgct ggaagtagaa agcgggtatg ccgaccaatt caatcgctac ttagacgtcg
    14701 tgaaaaacgt acaagcagaa acgaaagaac tcgttcaaac atacggagtc gtggacaaga
    14761 tgctggcaag ccgcggataa cgaagaaagg aat
//
