LOCUS       c00054_gnlPro..        10572 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LMIHIBLO_54.
ACCESSION   c00054_gnlPro..
VERSION     c00054_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:28:53
            Original ID  :: gnl|Prokka|LMIHIBLO_54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10572
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10572
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4565:10553]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4566..10553
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10572
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10572
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..433
                     /locus_tag="ctg54_1"
                     /transl_table=11
                     /translation="DKIKQDSLRTRAGREGWTHGRERTEISGKNEGASCSGKKEKEHTD
                     VKTNNCRIMYAEWTRVSGTEWVFTIKADRFLRNMVRAVVGTLVEVGRGKMTLDGFRKVI
                     ENKDRCSAGSSVPGHALFLVDVGYPEELFIVSPSDISNT"
     CDS             complement(399..1166)
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MILFIYDHTFEGLLTCIFDAYFRKTFPDLLLMEGEPLPLFYNEAI
                     HIATDEEKAGRVWRGLQKKISKHALFSLTCCWLSELPKVDEMLFHYIQKAINSPHSIET
                     NFADPDVLELAKIYKRVDGERVHLMQFVRFQKAADGTFFAAVKPQFNALPLAVDHFKDR
                     FADQRWLIYDVKRQYGYYYNLTEMEEVTFEDPRQAHLVTGMLNETLMDNNERLFQELWK
                     TYFKSICIKERWNPQKHRQDMPVRYWKYLTEKQ"
     CDS             complement(1163..2506)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_3"
                     /sec_met_domain="Radical_SAM (E-value: 7.9e-11, bitscore:
                     32.0, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRENAKPFAHSKHYLYFWQKYSDQMNENVLAKLKILAESAKYDV
                     SCSSSGTVRRNQSGALGNTVGGWGICHSFAEDGRCISLLKIMLTNYCIYDCAYCINRRS
                     NDIPRATLSVSELVDLTIEFYRRNYIEGLFLSSGVVRNPDYTMERLVRVAKDLRLVHKF
                     NGYIHLKSIPGASRELVNEAGLYADRLSVNIEIPKEENLKLLAPEKDHKSVYQPMRYIQ
                     QGILTNKEDRKKFRHIPRFVPAGQSTQMIVGATTESDKDILYLSSSLYQHPTMRRVYYS
                     GYISVNTYDKRLPALKQPPLVRENRLYQADWLLRFYQFKVEEIVDDSYPDLDLEIDPKL
                     GWALRHPEQFPIDINQADYEMILRVPGIGIKSARQIIASRRFSKLGFYELKKIGVVMKK
                     AQYFITCNELPTRTVNELTPTGVRRLLVPKPKKKVDERQLILNFTDNK"
     CDS             complement(2859..3425)
                     /locus_tag="ctg54_4"
                     /transl_table=11
                     /translation="MENKYITVAYKLYVMQDGQKTLVEEATVEHPFQFISGLGTTLERF
                     ETEITALKKGDKFKFVIPTAEAYGEYMPEGVRTVSKDMFTIDGVFDEERIFPGAVIPLQ
                     DNEGHHFYATVSEVTNDTVTVDLNHPHAGKDLTFEGEVVESRTATNEEIQEMVKMMSGE
                     GCGCGCGDCGEGCGDEGGCGCGHCH"
     CDS             3781..4155
                     /locus_tag="ctg54_5"
                     /transl_table=11
                     /translation="MKRLVLLVVVALGMSATSFAGEKVEGKDWKVDVNVAKLSKYLNLD
                     ARQMEEVANISDYFADKVQSASYAKEAKQGKKLREAVYGNFKLMKRTLTNEQYKKYVQL
                     LNVTLKNKGLDSYMEDVANK"
     CDS             4566..6368
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_6"
                     /sec_met_domain="ILVD_EDD (E-value: 1.3e-217, bitscore:
                     712.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFT
                     QFVPGHTHLHEIGQQVKVEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNNQHLDLID
                     AMIKSADASVSDEDVAQIENNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATH
                     ANRTQLFKDAAALIVKNAYKYYEEGDDSVLPRNIATRDAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGG
                     LLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELD
                     TDRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSDEELAARPMTAVTRDRK
                     VPKSLKAYASMVSSADKGGVRIID"
     CDS             6470..8167
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_7"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHRNT
                     LNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGN
                     AQDELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVG
                     MRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVLGNCKYTLAMLTQLIRKNE
                     HSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQM
                     MAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVM
                     KREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
     CDS             8178..8732
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_8"
                     /sec_met_domain="ALS_ss_C (E-value: 1.2e-19, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTQDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             8732..9475
                     /locus_tag="ctg54_9"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDILSFYREEV
                     EEKEYDIEVKKNGTDVVVRSKVIFI"
     CDS             9510..10553
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_10"
                     /sec_met_domain="IlvN (E-value: 1e-46, bitscore: 148.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.1e-41, bitscore: 131.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMS
                     VWPTIKPYLTQGKALYFSHGFAITWSDRTGVVPPTDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
ORIGIN
        1 ggataaaata aaacaagata gcctgcgcac gcgcgccggc agggaaggat ggacacatgg
       61 aagagaacgc acagaaattt ctggaaaaaa tgaaggagct tcttgctctg ggaaaaaaga
      121 aaaagagcat actgatgtga agacgaataa ttgccggatt atgtatgctg aatggacgcg
      181 ggtgagtgga acagaatggg tatttactat taaagccgac cgttttttac ggaatatggt
      241 aagggctgtg gtaggtacgc tggtggaagt ggggcgtggt aaaatgactt tagatgggtt
      301 caggaaggtg atagagaata aagatcgttg tagtgccggt agttctgtgc cgggacatgc
      361 cttgttttta gtagatgtgg gatatccgga agaactgttt attgtttctc cgtcagatat
      421 ttccaatacc tgacaggcat atcttgccgg tgtttttggg gattccaacg ttctttgata
      481 caaatggact tgaaatatgt tttccaaagt tcctgaaata atctctcatt gttgtccatc
      541 aatgtttcat ttagcattcc tgtgaccaga tgtgcttggc ggggatcttc aaatgttact
      601 tcttccatct ctgttagatt atagtaatac ccatattgtc gcttcacatc ataaatgagc
      661 caacgctggt cggcaaaacg gtctttgaaa tgatccacag ccagtggcag tgcgttgaat
      721 tgaggtttta cggctgcaaa gaaagttccg tccgctgctt tttggaaacg gacgaactgc
      781 atgaggtgta ctcgttctcc atctactctt ttatagattt tcgcaagctc cagcacatca
      841 ggatcggcaa agttggtctc aatagaatga ggagagttta tggccttctg gatatagtgg
      901 aaaagcattt cgtccacctt tggtaattct gataaccagc agcaggtcaa gctgaaaagg
      961 gcatgcttgg agattttttt ctgtaatccg cgccacacgc gtccggcttt ctcttcatca
     1021 gtggctatgt gtatggcttc attgtaaaac aagggtagcg gctcgccttc catcaagagc
     1081 aagtcaggaa aggttttgcg gaagtaagca tcgaaaatgc aagtcagcaa gccttcaaat
     1141 gtatggtcat agataaacag aatcatttgt tatcagtaaa gtttagtatt aattggcgtt
     1201 cgtccacttt ctttttgggt ttgggtacta acagtctgcg tactcctgtc ggagttagtt
     1261 cattaacagt ccgggtgggg agttcgttgc aggttatgaa gtattgcgct tttttcatca
     1321 ctacacctat ttttttcagt tcatagaatc ccagttttga gaagcggcgt gacgcgatga
     1381 tttgtcttgc cgatttgatt ccgatacccg gtactctgag aatcatttcg taatctgcct
     1441 ggtttatatc tataggaaat tgttctggat gccgtaatgc ccaacctaat ttggggtcga
     1501 tttccaaatc tagatcagga taggagtcat cgactatttc ttctacttta aattgataga
     1561 aacgtaacag ccagtcggct tgatacaaac ggttctcacg taccaatggc ggctgtttca
     1621 gtgccggaag ccgtttgtcg tatgtattta cggatatata tccagagtag tagacgcgcc
     1681 tcatggtggg gtgttggtag agtgaagaag aaagataaag gatgtctttg tctgattcgg
     1741 ttgtggcacc gacaatcatc tgcgtacttt gtccggcagg aacgaagcgt ggaatatggc
     1801 ggaatttttt tcggtcttct ttgttggtaa gtattccctg ctggatatag cgcatgggtt
     1861 ggtatacact tttgtgatct ttttcgggag ccagtaattt cagattctct tctttgggaa
     1921 tttctatgtt tacactgaga cggtcggcgt agagtccggc ttcattgact agttcgcgac
     1981 tggctccggg gatacttttc aggtgaatat atccgttgaa tttgtgtact aaccgcaggt
     2041 ctttggcaac acgtaccaac ctttccatgg tgtaatcagg attgcgtaca acgccggaac
     2101 tgaggaaaag cccttctata tagttgcgtc ggtagaattc gatggtgagg tctaccagtt
     2161 cgcttaccga aagcgtggcg cggggaatgt cattgcttct tctattgata caataggcac
     2221 agtcatagat acaataattg gtcagcatta ttttcagcaa ggatatgcaa cgaccgtcct
     2281 cggcgaagct atggcatatc ccccagccgc ctacggtgtt tcccaatgcg ccggattggt
     2341 tacggcgcac ggtcccacta ctagagcagg aaacatcata tttagcagat tctgcgagta
     2401 ttttcaattt ggcaaggaca ttctcattca tttgatcaga atatttctgc caaaaataca
     2461 gatagtgttt ggaatgggca aacggtttgg cattctctct gttcattttt aacttctttg
     2521 ttacattatg ttattcttta gtcttattat ctgtgtcttg caatagaaga aaaatgtgtt
     2581 tattacccag ctaaatgcat ttgtttcgcc tatgaatcaa gataaccggt cctatagtca
     2641 aaaagaaccg gacgttttta aaaaaggtct agttcttttt ttaaaagaac tagatgttta
     2701 atagaaaaga actagatctt ttttgaaaac ttcaagttct tttttttgaa atgtttgaag
     2761 aaacactgaa gctgccaatc agtattgttt cgttatcaat aataaaaaga gggcggatgt
     2821 tttgttccgt cctcttcttt atctattgtt taacgaaatt aatgacaatg tccgcatccg
     2881 catccacctt catcaccgca tccttctccg cagtcaccac aaccacagcc gcatccttct
     2941 ccactcatca tttttaccat ttcctgaatt tcttcattag tggctgtgcg ggattctact
     3001 acttcacctt caaaagtgag atctttacct gcatgaggat ggttcaaatc tacagttaca
     3061 gtgtcattgg ttacttcgct tacggtagcg tagaagtgat gtccctcatt gtcctgtaag
     3121 ggaatgacag ctcccgggaa gatgcgttct tcatcaaaaa caccatcaat ggtgaacata
     3181 tctttagata cagtgcgcac accttcgggc atatattctc cgtaggcttc tgcggtagga
     3241 atgacaaatt taaatttgtc acccttcttt aaggctgtta tttctgtttc aaagcgttcc
     3301 agtgtggttc ctaatccgga tatgaattgg aaaggatgtt ctacagttgc ttcttctacc
     3361 aatgttttct ggccgtcctg cattacataa agtttgtatg ctacggtgat gtacttattt
     3421 tccatgtttt cttattataa taatgtaata taaactattt acgtaagttt tttgttggca
     3481 aagatacgaa ttaattcccc ttaatccttt gttattacgt ttatattaca taaatttgtt
     3541 attatgatac tataaatgcg cttttgattg cgtttgattc ttgatataaa tcaattaacc
     3601 gctcgccttg atagattttt gctttaatta acggatatat gacaacatgt cgtaaagcat
     3661 gttgttatat ttgcagtgta aagagaaaga gataacgaga ttgtttttaa aaggtattat
     3721 ttagttctta ggtactaaat aaattgtttt taggtttaac aaattaaaat tttaggtatt
     3781 atgaaacgtt tagtattgtt ggttgtagtg gcattaggaa tgtcagctac aagttttgca
     3841 ggagaaaaag tagaaggtaa agattggaag gtagatgtta acgtcgcaaa gttgagcaaa
     3901 tatttgaatt tggatgcacg tcagatggag gaagttgcta atatttctga ttattttgct
     3961 gacaaagtac aaagcgcaag ctacgcaaaa gaagctaaac aaggtaaaaa attgcgtgaa
     4021 gccgtatatg gaaacttcaa actgatgaaa cgtacattga caaatgagca gtacaagaag
     4081 tatgtacagt tgttgaatgt tacattgaaa aacaaggggt tggattccta tatggaagat
     4141 gtggcgaata agtaaattta taaaatgaaa taaatgaact gaaaagagaa tgcaaaccaa
     4201 tgcattctct tttttattta tccgttggaa gatacagtgt atatttgtga taaaatgatt
     4261 gtttaaagct cgatttagtt acgaataata atttataaga aaaaaaatct tcattttatt
     4321 tgtttgttac gaaaaacgcc ttacctttgc agtcgttaaa gaaacaaaga aaacagatat
     4381 atgaatatta ctactctaaa taacctagca gtcctgcata ttattcgcgt cgtggtggtc
     4441 acactaggag cgtgagaaag gttgtgtatg tgtagttgta catataaaga aataattgga
     4501 agcctttctc acatggtgag gaaggctttt tcaataagta taggacgtta tagatttaga
     4561 ataagatgaa gaatcagtta cgcagttcgt ttagcacaca gggtcgccgt atggcaggag
     4621 cgagagcttt atgggtggct aacggcatga aaaaagaaat gatgggcaag cccattatag
     4681 ccatagtaaa ttcgtttaca cagtttgttc cgggacatac ccatctgcat gaaataggtc
     4741 agcaggtgaa agttgagatt gaaaaattgg gatgttttgc agcagaattc aatacgattg
     4801 ccattgatga cggaatagct atgggacacg atggtatgct gtattcactg cccagtcgtg
     4861 atatcattgc cgacagcgtg gaatatatgg tgaatgctca caaggcggat gcaatggtgt
     4921 gtatcagtaa ttgtgacaaa atcactccag gtatgctgat ggctgccatg cgactgaaca
     4981 taccggctgt ttttgtatcg ggtggtccta tggaagcggg agaatggaat aaccagcatc
     5041 ttgatttgat agacgccatg attaaatctg ctgatgcatc ggtcagcgat gaggatgtgg
     5101 ctcaaattga aaataatgcg tgtcctggct gtggttgctg ttcgggtatg tttacggcta
     5161 attccatgaa ttgcctcaat gaggctattg gtctggggct tccggggaat ggcactattt
     5221 tggcgactca tgccaaccgt actcagttgt ttaaagatgc ggctgctctg atagtgaaga
     5281 atgcttataa atattatgag gagggagatg acagcgtgtt accacgcaac attgctactc
     5341 gtgacgcttt tctgaatgcc atgacattgg atattgcaat gggtggttct accaatactg
     5401 tgctccatct tttagctatc gcccacgagg cggaagtaga tttcaagatg gatgatattg
     5461 atatgctttc acgccatgtg ccttgtttgt gtaaagtagc tccgaataca cagaaatatc
     5521 atatccagga tgtgaaccgt gccggtggta tccttaatat attgggagaa ttatccaagg
     5581 gtggtttgct gaaaactgat gtgaaacgag tggacggcct gacattggcg gaagctgtcg
     5641 aaaaatataa tatatgtaag aaagaagtgg atactgaagc aaaacgtatt tattcaagtg
     5701 ctccgggaaa caaattcaat ataaagttag gttctcagaa tgctgtttat aaagaactgg
     5761 atacagatcg tgccaatggt tgtatccgcg atttgcaaca tgcctatagt aaagatgggg
     5821 gtttggccgt tttgaaaggg aacattgcac aggatggttg cgtagtgaaa acggccggag
     5881 tggatgaaag tatttggaaa ttctcggggc ctgccaaggt gtttgattcg caggatgctg
     5941 cttgtgaagg tattttagga ggaaaagtag tcagcggaga tgttgttgtt atcactcatg
     6001 aaggtccgaa aggtggtccc ggtatgcagg aaatgcttta tcctacttcc tatatcaaat
     6061 ccaagcattt aggaaaagaa tgtgctttga ttaccgacgg acgttttagt ggaggaactt
     6121 cgggattaag catcgggcat atttctcccg aagctgcagc gggtggtaat atcggaaaaa
     6181 tagtggatgg tgatataatt gaaatcgata ttccgaatcg cagtatcaat gtgaaactga
     6241 gtgacgaaga attggccgcc cgaccgatga cagcggtgac ccgtgaccgt aaagttccta
     6301 aaagcttgaa ggcatacgct agtatggtaa gttctgcaga taaaggagga gtgagaatca
     6361 ttgactaaat tagaaattaa aaattgagaa taaaaaaaat agatttgttg tcattggtcg
     6421 attgtccggc atcgtatttt tttgattctc aattctcaac taaacaatta tggcaaaaga
     6481 aaagataaca ggagcagagg cgatgatgcg ttctttggag tatcaaggag tgaaaactct
     6541 tttcggatat cccggaggtt ctatcatgcc tacttttgat gctttatatc atcatagaaa
     6601 tacattgaac catatattgg tccgtcatga acaaggagct gcccatgcag cacagggatt
     6661 tgcccgcgta tccggtgagg ttggtgtctg tttggtgact agcgggcccg gtgcgacaaa
     6721 taccattact ggcattgccg atgctatgat tgacagcacg cctatcgtgg tgattgccgg
     6781 gcaggtagga gcttcctttt taggtacgga tgcttttcag gaagtggatc tggtgggcat
     6841 cactcagcct attaccaaat ggagttacca aattcgtcgt gcggaagatg tagcttgggc
     6901 tgtagcccgt gctttctata tagctaaaag cggacgtccc ggtcctgtcg ttttggactt
     6961 tgccaagaat gcacaagtgg agatggtgga ttatgaaccg atgaagcttg attttatccg
     7021 tagttatgat ccagaaccta atcctgataa ggaatctctt caggaggctg ccgaattgat
     7081 aaacaatgct caaaggccat tagtgttggt aggacagggg gtagagttag gtaatgcgca
     7141 agatgagtta cgtgcattta tagaaaaagc cgatatgcct tgtggctgta ctttgctggg
     7201 actttcggct ataccaactt cgcatccttt aaacaaagga atgttaggta tgcatggaaa
     7261 tctggggccc aatgtcaaaa ctaatgaatg tgatgtgttg attgctgtag gtatgcgctt
     7321 tgacgatcgt gtaactggaa aattagatac atatgctaaa caggcaaagg tgattcattt
     7381 ggatattgac cattctgaaa tagataagaa tgtaaaagtg gatgtacccg tattaggtaa
     7441 ttgtaaatat acgctagcta tgctgacgca acttatccgg aagaatgaac attccgaatg
     7501 gattgatagc tttactgaat atgaaaagac ggaatatgaa catgttatca gtaaagaaat
     7561 tcatcctgtt gacggggcgt tgaatatggg tgaagtggtg cgtgcggtaa gtgaggcttc
     7621 gaacaacgag gctgtattgg tgacagatgt aggacagaac caaatgatgg ctgctcgtta
     7681 ttttaaatac agtaagaacc gtagcattgt aacttcgggt ggattaggaa cgatgggatt
     7741 cggtcttccc gctgctatag gcgctacttt cggtcgcccg gatcgtactg tatgcgtatt
     7801 tatgggggat ggcggtttgc agatgaatat tcaagaattg ggaactatca tggagcaaaa
     7861 agcaccggta aagattattt tattgaacaa taactatttg ggtaatgttc gtcaatggca
     7921 agctatgttt tttggtcatc gttattcatt tactccgatg ttgaatccgg attatatgaa
     7981 gattgccgag gcatatgaga ttcctgcccg ccgtgttatg aagcgtgagg aattgcaggc
     8041 tgctatccat gaaatgttga ctactgacgg gccattcctg ctggaagctt gtgtgataga
     8101 agagggaaat gtgttgccga tgacacctcc gggaggctcg gtgaatcaga tgttactgga
     8161 atgctaattt aataattatg gacaagacat tatatacatt aatcgttcat tcagaaaata
     8221 tcgccggttt gctgaaccag attacggcag tgtttactcg ccgccaaatt aatatcgaaa
     8281 gtcttaatgt ttctgcatct tccatcaagg gggtgcataa atatactatt actgcttgga
     8341 ccacccagga tgtgatagaa aaagtggtga agcagattga aaagaaaata gatgttttgc
     8401 aggcacatta ttttactgat agtgagattt atcagcatga gattgctttg tacaaggttt
     8461 ctactcctga atttcaggag aatcctatgg catctaaagt tatccgccgt tatagtgccc
     8521 gcattgtaga agtgaatccg gttttctcta ttgttgaaaa gaatgggatg agtgaggaaa
     8581 ttactgctct ttatgaggag ttgcgcggat tgggatgtgt gttgcagttt gtccgttcgg
     8641 gacgtgtggc cattactacc agctgtttcg agcgtgtgaa cgaatatctg acccaacgcg
     8701 aggaaaagta tcgccagcaa aaaacagaat aatgatgagt gagaataaag taggaacata
     8761 cagatttgtg gcagaaccct ttcactgtga tttcagtgga aagttgacca tgagtgtgtt
     8821 gggtaatcat ttactgaatt gtgccggctt tcatgctgcc gaccggggtt tcggaattgc
     8881 tacgctcaat gagaatcatt atacatgggt actttcccgt ttagctgtag agttagagaa
     8941 tatgccctgt caatatgagg gtttcagtat tcagacatgg gtagagaatg tttatcgtct
     9001 ttttacagac cgtaattttg caattttgga caaggaagga aagactgtcg gatacgcccg
     9061 ttctgtatgg gcgatgatca gtatggaaac tcgcaaacct gctgacctgc ttacgcttca
     9121 cggaggtagt atcattgatt atgtatgcga taagaaatgt cctataagca agcccggtcg
     9181 tattaaggtg acagagaaag ctccggtttc tgaataccag accagatata gcgatattga
     9241 tattaatggt catgtgaaca gtattaagta tatagaacat attctcgatt tgtttcctat
     9301 agagtttttt aaagagaaac ggattaaacg ttttgagatg gcttatgtag ctgagagtta
     9361 ttatggtgat atattgagtt tctaccgcga ggaagtggag gagaaagaat atgatataga
     9421 ggtgaagaag aatggcacag atgttgtcgt tcgtagtaag gtgatattta tttagaatct
     9481 aatttttaat ttttaattta taatttaaaa tggcacaatt gaattttggc ggcgttacag
     9541 aaactgtagt tatccgcgat gaatttcctt tggaaaaagc acgtgaagta ttgaaagatg
     9601 aaacaatcgc tgtgatcggg tatggtgtac agggaccggg gcagtctttg aatctccggg
     9661 acaatggttt caatgtaatt gttggtcagc gtccgggaaa aacatatgaa aaagcagttg
     9721 ctgacggatg ggttccgggt gaaactctgt ttggtattga agaggcttgt cagaaagcga
     9781 ctatcgtaat gtgtctgtta tctgatgcag ctgttatgtc tgtatggccg actatcaaac
     9841 cttacttgac ccaaggcaag gcactttatt tctctcatgg ctttgccatt acttggagtg
     9901 accgtacagg ggtagttcct cctactgata ttgatgtgat catggtagct cctaaaggtt
     9961 cgggtacttc actgcgtacc atgttcttgg aaggtcgtgg cttgaactct tcatacgcta
    10021 tctatcagga tgtaaccggt aaggcttatg aacgtactat tgcattgggt attggtatcg
    10081 gttcaggcta tttattcgaa acgactttcc agcgtgaagc aacttctgac ctgacaggtg
    10141 aacgcggttc tttaatgggg gctatccaag gattgttgtt ggctcagtat gaagtattgc
    10201 gtgaaaacgg acatagtcct tctgaagcat ttaatgaaac tgtagaagaa ttaacccagt
    10261 cattgatgcc tttgtttgct aagaatggta tggactggat gtatgctaac tgctctacca
    10321 ctgctcagcg cggtgcattg gattggatga ccccatttca cgatgctatc aaacccgtag
    10381 ttgaaaagtt atatcacagt gtgaagactg gcaacgaggc tcagatttct atcgattcta
    10441 actctaaacc cgattatcgt gaaaaattgg aagaagaatt gaaggcattg cgtgaaagcg
    10501 aaatgtggca gactgctgta accgtacgta aacttcgtcc tgaaaataat taataatgcg
    10561 aatcagtagt tg
//
