LOCUS       c00021_gnlPro..        15560 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HKNGKOGP_21.
ACCESSION   c00021_gnlPro..
VERSION     c00021_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 05:46:34
            Original ID  :: gnl|Prokka|HKNGKOGP_21
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6516
            Orig. end    :: 22076
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15560
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16516:19633]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13117
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15560
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15560
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(103..1650)
                     /locus_tag="ctg21_8"
                     /transl_table=11
                     /translation="MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSM
                     LVEMIKTLRSGKYGVDLLAITAIVATLAVGEYWASLVVLIMLTGGDSLEDYAAKRANTE
                     LKALLDNSPRIAHRSVAGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFDESS
                     LTGESKPVDKHVGDDIMSGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVR
                     LADRYAVPFTLVAYVIAGVAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSR
                     NGIVVKTGDMLEKLSTAKSAAFDKTGTITSGQLTVNQIVPQPGFTAEQILHLAASAEQN
                     SSHILARSLVKYASATSLSPATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLA
                     TTAIYVGIDDQYAGYITFIDNVRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADV
                     GIDTVAADLLPADKIAHLKAVPAGERPVIMVGDGVNDAPSLAVADVGIAMAPMLNCC"
     CDS             2565..4091
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BCCT"
                     /gene_functions="transport (smcogs)
                     SMCOG1001:betaine/carnitine/choline family transporter
                     (Score: 401.8; E-value: 1.1e-122)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_9"
                     /sec_met_domain="BCCT (E-value: 3.9e-123, bitscore: 401.8,
                     seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNWLTNNMSWLYMSVYVITFIFFIYLGFSKLGKTKLGDPDDKPEF
                     STYHWGSMVYATGIDASILMLSMVDPLRYLQSPSFGVKPFSTSAYNYAHMLGQFNWGPM
                     AWMMFAPATIAIAYAMYVKHIKVQRLSAAISVLQGPGKGKQIARNTIDFLVIIGIMGGV
                     GTSVGMEIPVISKVLSAVTGIADTMTLKLGLFALLFVIFAMAVFNGLKKGIGRLSAAHV
                     WLAIGFLIVVLIVGPTLYILNSETNSIGLFVNKFITLSTNTAPNGHATAMQRQTIFYWG
                     WWLSFMPVMGLFIARISRGRTIRQVLGGMLLWGSLGCVSFYAILGGYALYLQRMGIVNL
                     VHILNTQGQAAVIAAVLSTLPLKMIMLALYCLSCFIFLATTVSSFAFITSSFTSKKLAA
                     GEQPSRFNRMSWVVIFLVFSLGLVTVGGFESIQSICAMSGFPLTIVALVLLYSIHHDLT
                     TDPVKEAAKANAKAAELARRKRLARDVEITTKTDYARERRTARKRETEAD"
     CDS             complement(4205..4387)
                     /locus_tag="ctg21_10"
                     /transl_table=11
                     /translation="LAWLVEDQYLRRGLRLKSVSTAFQQLAEMPGGRRRTNELSRFTLT
                     GTVSSGPKLVAVDFK"
     CDS             4394..4681
                     /locus_tag="ctg21_11"
                     /transl_table=11
                     /translation="LLSGISPLSIGRNAFQSGQYSNGGRRCTQLLMNLSLFSINSNFVN
                     QLLGRKDIGIARYFGITIVIIEHLNKVVRVTLTSRLKFLYQNNQRPIVPS"
     CDS             5106..5747
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lipase_GDSL_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_12"
                     /sec_met_domain="Lipase_GDSL_2 (E-value: 2e-20, bitscore:
                     64.4, seeds: 1564, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAISNGHVSFKRPAWLGDSITANNGLTTVHYHDILAADWDVERSD
                     NLGISGSTIGSRYDAMAARYQAIPEDADFIAVFGGVNDYGRNQPLGQYGDCDMTTFYGA
                     LMVLLTGLQTNWPTVPKLFISAIHIGSDFGGSFSAVTNGLGYRQSDYEAAIAQMTADYG
                     VPHLSLYRDAGMTFAIPTQAAIYSVDTLHPNNAGHRVIARKLQSFLDSHF"
     CDS             6451..6696
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_13"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 4.4e-05, bitscore:
                     13.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPLSSFEKNIPAVTELLAVDAELQTFFVALTPGYQREWARFI
                     FGTKAQATKERHIEVMKTVFRAGYKSKRAYDSRPDK"
     CDS             complement(6791..7315)
                     /locus_tag="ctg21_14"
                     /transl_table=11
                     /translation="MTSTCTICERIKLIQAHQNPYFVYELTTGYVVLADSQYFEGYTLF
                     LAKHHVTELHHLPAHEKLRYLEEMSIVQEACAQAFHADKMNIELLGNGDAHVHWHLFPR
                     HNGDTLNPGPVWWTPLETIYGDDVSLDIPRLSRLKRTLSVAIEATLNAREAELQALEAL
                     TRPASHRIDSN"
     CDS             complement(7485..8405)
                     /locus_tag="ctg21_15"
                     /transl_table=11
                     /translation="LKTINLGHSNIQASSVALGIMRMDALDVAQATKVIDTAADLGINY
                     VDSADIYGGGQSSTIFGQALKQAHVSRDQLYIQSKGGIVPGKRYDFSKQHILAAVDGEL
                     QRLGVDYLDTFLLHRPDALMEPEEVAAAFDKLQTSGKVRHFGVSNFNPMQVDMLQAALN
                     QRLIINQLQFGIMHTGAIDFGLHTNMQDERSLNHDGEMIEYSRLHKMTIQAWSPYQYGN
                     FAGIFLDNPKFPELNNAMQALADEKQVTKSAIATAWILRHPAHFQVVLGTMNPEHLAQN
                     AAGADVTLSRQEWYDIYFAAGNDLP"
     CDS             9448..9777
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FeS_assembly_P"
                     /gene_functions="other (smcogs) SMCOG1048:Iron-sulfur
                     cluster assembly protein (Score: 66.9; E-value: 4.7e-21)"
                     /gene_kind="other"
                     /locus_tag="ctg21_16"
                     /sec_met_domain="FeS_assembly_P (E-value: 1.6e-21,
                     bitscore: 66.9, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGRDTMTTTFKDRAFEALGHVIDPELGIDLVNLGLIYDAQLTAE
                     GTAEITMTLTIAGCPLTEWLAKDIHDELIKLPEVNNIEIEIVWEPAWNESMMSREARME
                     LGIHS"
     CDS             complement(10001..10822)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 74; E-value:
                     4.8e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_17"
                     /sec_met_domain="Radical_SAM (E-value: 8.1e-28, bitscore:
                     88.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKQVSTTQAAAKEPLIGYVHSIETFGSVDGPGIRYVAFLQGCH
                     MRCQYCHNPDTWKLNVGDQMTADEILEDAAKYRAFWGKTGGITVSGGESLVQIDFILDL
                     FEKAKAMNISTCLDTSGQPFTREQPFFDKFERLMKVTDISLVDIKHIDSAKHKQLTQYG
                     NENILDMIQYMAQHHDDMWIRHVLVPQRTDYDEDLKKLGDYIAKIPNDVVQKVEVLPYH
                     TLGVKKYHEMKIKYRLEGIESPTQDRVANAEKLLHTADYNGYKTWMPLPKL"
     CDS             complement(10859..13117)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_18"
                     /sec_met_domain="Gly_radical (E-value: 5e-40, bitscore:
                     126.9, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 8.3e-247, bitscore:
                     810.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITSEKTTKPAAWKGFKGGHWQEEINIRDFIQNNFTQYNGDESFL
                     AGPTAATKTLNDKVLELKKQERAAGGVLDADTKVVATITSHGPGYIQKDLEKIVGLQTD
                     KPLKRAFMPFGGIRMADDALKSYGYTPDEENDKIFTEYRKTHNQGVFDVYTPDMRKARH
                     YKIITGLPDAYARGRLIPDLPRVAVYGIDRLMEDKANDFAHIGDGELTDDVIRLREEVQ
                     DQYRALADMKKMAASYGYDISKPATNAQEAIQWMYFAYLAAIKTQNGAAMSVGRIDTTM
                     DIFIQRDLDNGVLDESQAQELIDQFVMKLRMVRFIRTEEYNSLFSGDPIWATLSMCGLG
                     VDGQHHVTKTAFRILKTLDNMGAAPEPNITILWSDRLPEDFKRYATEVSIDSSTIQYEN
                     DDLMRVQWGTDYYGIACCVSAQPIADGIQYFGARANLAKAILYAINGGRDEIAGDQVGP
                     AYEPITSEYIDYDEFMKKLDKQMDWLADTYVNSLNAIHYMHDKYYYEAAQLALKNTDLD
                     RTFATGISGLSHAADSISAIKYGHVKVIRDERGIAVDFKADNDYPRYGNNDDRADDIAK
                     WLVKELYSKMNTHHLYRNAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPAY
                     GAEKSGALASLLSTAKLPYRYATDGISNTFGVTPNTLGHDLESRKDTLVNMLDGYMKND
                     GMHLNINVFNKDTLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVISRTFFESM"
     CDS             13535..14524
                     /locus_tag="ctg21_19"
                     /transl_table=11
                     /translation="MRMLEKIEQYIDSCIEAGDIYGASFSLITPKGINQYYHGKQGRDE
                     FAVGLDPAMIYDLASVTKVVGTTTRIFQLLSDHTIHLTDSVARFLPGFTHPEITIKNLL
                     LHNSGLPADIDNLDKMQREDLIKAVYDAPLVTAPGTTYVYSDLGFILLGWIIRAVDGSL
                     ARSIQDHVCYPLAMTNTGYNLNRPKIRFVPTEFDPRRGQIQGQVHDYKAFLLNGESGHA
                     GLFSTLTDLSVFIEMMLNFGEYQGKRVLDENVFDWLGEYDENGRTLGWERRAGRHQYFH
                     TGFTGPAVAFDLDRQIGLVVLTNRVYPTSDNQVWNQDRKRVFDLFFES"
     CDS             complement(14692..15207)
                     /locus_tag="ctg21_20"
                     /transl_table=11
                     /translation="MLAWLPFFLISLMFIVLLYACTRSVRTNIQRFKQLSLIAFLWVLT
                     AFCYTPTSYNFGTQLVIQYIQWGPVKLNVIPFQQLDIEFWLNVLLTVPLGGLLAWNFPD
                     LPWRRFIWLGFLTGLTLELGQFILDWLVNLKRWVDIDDVITNWAGVIIGAAGYKIARHV
                     PGLRWLQK"
     CDS             complement(15430..15558)
                     /locus_tag="ctg21_21"
                     /transl_table=11
                     /translation="LCSVFKDLIPCVNRLTQLNHHNILINILSTTFFLRSNLINLS"
ORIGIN
        1 caaacggctt gtttagccac ttgcatggta tctttagcaa tgcgcaccgc cgtgaccacg
       61 cgactaagat cgtcttttaa gatgacgacg tcggccgatt cactagcagc agttgagcat
      121 gggcgccatg gcgatgccga cgtcagcaac agccagggaa ggcgcgtcgt taacaccatc
      181 gccaaccatg ataacggggc gttcgcccgc tggtacagcc tttaagtggg caattttatc
      241 tgcgggtagg aggtcggcag caacggtatc gataccgaca tcggcggcaa tatgatcagc
      301 aattgcctgt tggtcaccag taagcatcat gacgttttga acgccctcag cgtggagtgc
      361 ttgaagcgtg gcggctgctt cggggcggac attgtcgata aacgtgatgt aacccgcgta
      421 ctggtcatca atgccgacgt agatagcagt ggtagcaagt ggcttggcgg ttgtagtcgg
      481 tgcgacgaat ttaagtttgc ccactttgac ctgttgctgc tcaatcgttg ccgtgacccc
      541 attacccgtt acttctgcta attgtgttgc cgggctgagg ctagtggcac tcgcatactt
      601 gacgagtgag cgggccagaa tatgacttga gttttgttca gcgctcgctg cgaggtgcaa
      661 gatttgttcg gcagtaaaac caggctgagg aacaatttgg ttgactgtta attgaccact
      721 ggtaatggtc cccgtcttat caaacgcggc ggacttagcc gtagataact tctccaacat
      781 gtccccagtc ttgaccacga ttccgttccg actagttcgg ctcatccctg agacgagtgc
      841 aacgggtgcg gcgagaatca gcgggcaagg tgaagccact acgaggactt ctgcaaatcg
      901 gtggggatca ccgctgaatg cccaagctac tccggcaatg acgtatgcta ccaaggtgaa
      961 tgggactgca tagcgatcgg ccagccgtac gaatttggct ggtcgtgatt cggattcttt
     1021 aaccaatttg actaactgtt ggtattgact atcaatggct aatttatcaa caaccattgt
     1081 aacagcacta tcgccgttga ccgcaccaga cataatgtca tcgccaacgt gcttgtcgac
     1141 tggcttagat tcacccgtca atgaagattc atcaaagagt gccgttcctt gaataaggtg
     1201 accgtctact ggaactagct caccaggttt gacgactagc tgatcaccaa tttggacatc
     1261 ttcaacggca atatctgtta attggccggc gactgagcgg tgggcaatac gtggtgaatt
     1321 atcgagcaag gctttcaatt cggtattcgc tcgtttggcc gcataatctt ctaacgagtc
     1381 acccccagtg agcataatta gaacgacaag gctagcccaa tattcgccga cagctagtgt
     1441 tgccacaatc gccgtaattg ctaataaatc aaccccgtac ttacctgaac gtaaggtttt
     1501 gatcatctca actaacattg ataaggccat aagtgacccc attaatgtaa tgatgatttg
     1561 tgctgccaat tggtagtgca aaccaaactg taaaataacc gcaatgatac cgacgctgac
     1621 cgttaaaatt aatttatagt agtgccgcat gcagttcccc tccttttaga tgataacgtt
     1681 ttttttttac ttgttacaag aataacatga aatcggttta attgaaacag ataagaatga
     1741 ttctaaacta aaaaactaat tattacgaaa acttttaaaa agtttcagaa aaaatatggg
     1801 tgcaaaactc gtctaatcct tgacgggtta ggcctcgacg gctcaaaatg gttgatttta
     1861 cttctgattt aatactagta tacttataaa cgaacatcag atatcagaaa atactgaaat
     1921 cagcatttgt ataagccaac gtgcgctgtg caggtggtaa cttgttaccc ggtactaagc
     1981 gcttttttgg tgcaccaagc aattaatcta acagttgtgc ggtgggctta tctggtgatt
     2041 caagggggtt atctattagc aagagcagtg taaccattaa tcgttacgtg gtgtgacgac
     2101 ggtcgtgtgc taaaggcacg atggtaatag aaacactagc taaacaagat gaacaccaac
     2161 gtcgattaag caattaaaaa tcatttgtca gtatggcgtt gtccggattc aaccaacgga
     2221 aagaaggaaa ttctgctact gattttgagt tagcacaaac agaatgcgga tgacaatgcc
     2281 ggtcaaacct gatacagtca gggtgctgag tgctccgagg attaactcgg aggggtgtac
     2341 cgattgctag tcggaaattt acgcgtgggg actaccattg ctggtaggaa gaaccacgaa
     2401 tttgatctaa atatagagag tatatgctca gtagcaggtt tattatttta aaaagtaaga
     2461 atattgattg gtgggtctat ttaccaacaa ttgggctctt tgcggcggct tccgttgttt
     2521 tattaatggg gggccattcg ctggagacga gtttaagtgg catcttgaac tggctcacaa
     2581 ataacatgag ctggctttat atgtcggtat atgtgatcac ttttatcttt ttcatttact
     2641 tagggtttag taagttaggg aaaaccaaac ttggtgatcc tgatgacaaa ccagaatttt
     2701 caacgtatca ctggggcagt atggtttacg cgaccgggat cgatgccagc atcttaatgt
     2761 tgagcatggt tgacccgtta cggtacctcc aaagcccttc attcggcgtc aagccgtttt
     2821 caacttctgc atataattat gcgcacatgc tgggacaatt taattgggga ccaatggcgt
     2881 ggatgatgtt tgcgccagcc acgattgcaa ttgcctatgc aatgtatgtt aaacacatca
     2941 aggttcagcg gctcagtgcc gcaatttcag tactacaagg tcctggtaag ggtaagcaaa
     3001 ttgcccggaa cacgattgat tttctcgtta ttattgggat tatgggtggt gttggtactt
     3061 cagtcgggat ggaaatcccc gtcatttcaa aagttttgag tgccgttacc gggattgccg
     3121 atacgatgac tttaaagtta gggttatttg ccttattatt cgtaattttc gccatggctg
     3181 tttttaatgg tttgaagaag ggaatcggtc ggctaagtgc tgcccatgtt tggttagcga
     3241 ttggcttcct aatcgttgtt ttaattgttg gcccaacttt gtatatttta aactcagaaa
     3301 ctaatagtat tggcttgttt gtcaataagt ttattacgtt gagcacgaat actgcaccaa
     3361 atggtcacgc aacggccatg caacggcaga cgatcttcta ctggggctgg tggttatcct
     3421 ttatgccagt catgggctta ttcattgccc ggatttctcg gggccggacg attcgtcagg
     3481 tactcggtgg tatgttgcta tggggctcat taggttgtgt cagtttctac gccatcttgg
     3541 gtggttatgc cttatacttg caacggatgg gcatcgttaa cttagttcat atcttaaata
     3601 cgcaaggaca agccgctgtg attgcagcag tattgtcgac cttaccattg aagatgatta
     3661 tgctggcttt gtactgccta tcttgcttta ttttcttagc aacgacggta tcttcatttg
     3721 ccttcattac ctcgtcattt actagtaaaa agttggccgc gggggaacaa ccaagtcgtt
     3781 tcaatcggat gagctgggtc gttatcttcc tagtcttctc attggggctt gtcacggtcg
     3841 gtggctttga atcgattcag tccatctgtg cgatgtctgg cttcccatta acgattgtcg
     3901 cgctcgtctt actgtactcg atccatcacg acttaacgac tgatccagtc aaggaagctg
     3961 cgaaagccaa tgccaaagca gctgaattag cacgccggaa acggctagca cgtgacgttg
     4021 aaatcacaac taaaactgac tacgcacgcg aacggcgtac tgcacggaaa cgtgaaacgg
     4081 aagccgatta gcgctactca gttgaactaa atatatcaat taaactaggc tcgtattatg
     4141 gatttccata atacgagctt ttaagattgg cccacctgtt tgaaataatg gtagaaagat
     4201 gcctttattt aaagtcaaca gccaccagct taggcccgct ggaaacagtt ccggttagcg
     4261 taaacctgct tagttcgttc gtcctacgcc gccctccagg catttctgcc aattgctgga
     4321 acgcggtgga cacagattta agccgaagac cacgtcttaa atactggtct tccactaacc
     4381 aagccaagga cgcttgctaa gtggaatttc accgctgagc attggccgaa acgccttcca
     4441 gtcgggacag tattcgaatg gcggacgaag atgtacccaa cttttgatga atttgtcatt
     4501 gttctccata aacagtaatt ttgttaatca actgttaggt cgaaaagata ttgggatagc
     4561 tcgctatttc ggaattacta tagtaataat agaacacctc aacaaagtgg ttagggtaac
     4621 cctaacgtct cgtttaaagt tcctgtatca aaataaccaa cgaccaattg tgccgagtta
     4681 agtggccgtt catcagccat tcgagcggct tcctgaaacg tgttcggtgc cactaaagtc
     4741 tgtgcttgct atgccaacgg acaaatgccc aaaccgcatt aatccgttgg ctagacaatg
     4801 ctcggcttca acccgtggct tgagactgga ggggctgggt gacaatgctc agtagccaaa
     4861 ttattcttag tcggaagtga tttccttccg gcttagaata agactcgtat ttgagatgac
     4921 gcgggttatg cgttagctca aatcgatgtc ggctgcgttc cagcaattgt cacccagccc
     4981 cggaggtcgg aataggacgc tcaccggctg acgaacagaa aaccaaccct aaaaggcatc
     5041 tttctaccat aattcagatg ggatggatta gaatggtagc gatgatagta aagggaggat
     5101 tggctatggc gattagtaat gggcacgtta gttttaagcg gccggcgtgg ttgggagatt
     5161 cgattacggc gaataatggg ttgacgacgg tgcattatca tgatattttg gcggctgatt
     5221 gggatgtcga gcggagcgat aatttgggaa tctctggttc aacgattggg agtcgctacg
     5281 atgcgatggc ggcgcgctat caagctattc ctgaagatgc tgattttatt gctgtctttg
     5341 ggggcgtcaa tgactatggt cggaatcagc cgttagggca atacggtgat tgcgatatga
     5401 cgacatttta tggcgcgtta atggtgttac tgacgggatt acagacgaat tggccgaccg
     5461 tgccgaagtt atttatttca gcaattcata ttggctctga ttttggcggc agttttagtg
     5521 cggtgactaa tggtctcggg tatcgtcagt cagattatga agcagcgatt gcccagatga
     5581 ctgcggacta tggcgtccca catttgagct tgtaccgtga tgcgggaatg acgtttgcga
     5641 ttcccactca agcggccatt tattcggtgg atactttgca tccgaacaat gccggtcatc
     5701 gcgtgattgc acgcaagctg cagtcgtttt tggatagcca cttttaggtt ggcctagtca
     5761 gtaatgaatg gcacagttga tcgtaaataa aagcagcagc acgctaatga gcgtactgct
     5821 gcttatctga atctaggtgt caaaacgggc tacttggctt ttttcttagt cttgggccct
     5881 tgtttatgct tctgctcgcg cagcaagtct ttgaaggttt cgatttccgt agtgtgctta
     5941 gccatccatt ccttgtagtt agaatgggag tcggtatcgc tgattttaag gccggtttct
     6001 aaccagaata aagcttcggt tagggaaccg aaattatgaa accagagtgt gtggccgttg
     6061 tcagagtcca tggcaacgta agacttgtag tggggcgtta aaaaggtatg tttaacaatt
     6121 ttgaatgcgg cccggcgacg agttaatttg taatccggca agatatagcg gccaggatgg
     6181 gccagatgtg ggacagagtt cttacgttgt tctttatatt cagtcaacat cgctttagcg
     6241 cgttcgggac tgatgagggt gatatcaaat tttggcatag cagggctccc cttggtgaat
     6301 agcagtatgg ttaattatag tagtcaaata ataatactta tactataatg atagcgcaat
     6361 tttatgaaaa ttcgaaatat aaaaacctga aaattaggga ttttcccttt cttacagtaa
     6421 atttaagtaa aactaatcgg aggtttgatt atgagtacag cacccctcag ttcatttgaa
     6481 aaaaatattc cggcggtaac cgaattgtta gcggttgatg ctgaattgca aacgttcttt
     6541 gtggctttga cacctggtta tcagcgcgaa tgggcccgct ttatttttgg aactaaggca
     6601 caagcaacta aggaacggca cattgaagtt atgaagacgg tttttcgagc tggctataaa
     6661 tctaagcgag cgtatgatag tcggccggat aaataggtgg attttggcaa tttgaaatac
     6721 ggtgacggat tgcgattaag aattggggtg tagccaccaa gatctaagcg ggtctgggtc
     6781 ctgatttggt ctaattgctg tcaattctgt ggctagcagg ccttgtgagt gcctctaaag
     6841 cctgcaattc tgcttcccga gcattaagcg tggcctcaat tgctacgctg agcgtgcgct
     6901 tcaaccggct taaacgggga atgtctagac tgacatcatc accataaatt gtttccagcg
     6961 gtgtccacca gacgggaccg gggttgagcg tatcaccgtt atggcgagga aataagtgcc
     7021 aatgaacatg cgcgtcacca ttcccgagta gttcaatgtt cattttgtct gcatgaaagg
     7081 cctgcgcaca agcttcctgg acgatactca tctcttcaag gtatcgtaac ttctcgtgtg
     7141 ccggtaaatg atgtaattcg gtaacgtgat gtttggctaa aaagagcgtg tagccttcaa
     7201 agtactggct atcagcaagg accacgtagc ccgttgtgag ttcgtaaacg aaataaggat
     7261 tctgatgtgc ctgaattagt ttgattcgtt cacagatcgt gcaagtggat gtcattcgct
     7321 cgcctcctga gtcttgataa gattaagtat acgcgtagat gtggtgagta catcaaaaat
     7381 gttagtgaaa cgtctaaaaa acgacgacct gaaaatcaat cctgatttgg ggtcgtcgtt
     7441 ttgattgtaa aaactaatcg tcaattctgt taggtcgatc gtgattaagg taaatcgttg
     7501 ccagctgcaa agtaaatgtc gtaccattct tgccgagaaa gcgtaacgtc tgctccagca
     7561 gcattttgag ctagatgttc cggattcatc gtaccaagga cgacttggaa gtgggctggg
     7621 tgccggagaa tccatgcggt cgcaatagct gatttagtga cctgtttctc atcggcgagt
     7681 gcttgcatgg cattattaag ttctggaaac ttcggattgt ctaagaagat acccgcgaag
     7741 ttaccgtatt gataaggcga ccaagcttga atcgtcatct tatggagccg tgagtattcg
     7801 atcatctcgc cgtcgtggtt aagactacgt tcgtcctgca tgttcgtgtg caagccaaag
     7861 tcgatcgcac cggtatgcat gataccaaat tggagttggt tgatgatgag ccgttggttt
     7921 agtgccgctt gaagcatgtc aacttgcatg ggattgaagt tagagacgcc aaagtggcgc
     7981 accttgccgc tagtttgcaa cttgtcaaaa gcggcagcaa cttcttcggg ttccatcagg
     8041 gcgtccggtc gatggaggag gaaggtgtcg agataatcaa cacctaagcg ttgaagctcg
     8101 ccatccacgg ctgccagtat gtgctgtttg gaaaagtcgt aacgcttgcc aggaacaatg
     8161 ccgccttttg actgaatata gagctgatca cgcgatacgt gagcctgctt gagtgcttga
     8221 ccgaagatgg tcgatgattg accaccaccg tagatatcag ctgaatcaac gtaattgatg
     8281 cctaaatcag cagcggtatc gataaccttg gtggcttgag cgacatccaa ggcgtccatg
     8341 cgcatgatgc caagcgccac gctggaagct tgaatattgc tgtgacctaa attaatcgtt
     8401 ttcaaaacta aagtcctcct caatgtgcaa cttgatttaa attcagtata cggttttcgt
     8461 aagaggatgt aaacggttac gtctggtgcc gactgttggt aaatctgatt ttagagcaaa
     8521 aaaatagaac ccaaggcttc tctgcttgag ttctacttat gaggaataat cctgattagc
     8581 aatgaaaaat tgttcagtgt taatatgata caccttcatg ctattcaatt ttacgcgtgt
     8641 ccaacttcta acggactaac ccgtatttat tgtaactatc tgctatagtc gatctaaagt
     8701 aaggttgtta cttgattgcg actcgttaga cgggttttaa cgaaagtcaa actcgcgttt
     8761 aaaacttggg aatgtcttcg taacagacat gcacctccgt ttaaactttg taatacctga
     8821 gtctacaaat ggaactggta atgtggaact aacaactggt catcggagac acctgtttcc
     8881 aactaaaact tagttaaaat ctgttcgtca ttctaatgcc aattaattct ttgcggttat
     8941 cgtttatcta agggtcaacg ttcagtcatc caacgtaaat ctcacgacac tcgctagacc
     9001 gataacgctt cacggcgctt aaaacggttt cgataacgac ccaaactgtg atactagctg
     9061 tctaacatta cagcgacagc caaactcttt tgagaagctt tgctaatcga ggattaattc
     9121 ctttcctcac ttagtataat agcataaacc gcaaacgctt acaacaaaaa caaccgtgaa
     9181 ttcgcaataa aaatcaatag tgactcaaaa cgctgctata tcggggatta tagtgaattt
     9241 ttttcgagaa atagtcgcat aatttgctga ttgaccgacc gtttgaaaag tcggttaatt
     9301 agcgctaata attgattgaa tatgggctga catacggtac aatagaagta gacaagaaag
     9361 cgctttatat aacgatgacg tgtatcaagt gtggtggcac ttataccgcg aaacgttggc
     9421 gtgattaatc agtgaattca agctggtatg gaaggacgag atacgatgac aacaacgttt
     9481 aaagaccggg ccttcgaggc gctaggacat gtcattgacc ctgaattagg aattgatcta
     9541 gttaacttgg ggttgatcta tgatgcacaa ttgacggcgg aggggaccgc tgaaattacc
     9601 atgacgttga ccattgcggg ctgtcctttg accgaatggt tggctaagga cattcacgat
     9661 gaactgatca aattaccaga agttaacaat atcgagattg agattgtgtg ggaacctgct
     9721 tggaacgaaa gtatgatgtc ccgcgaagct cgaatggaac taggcattca tagttagtgg
     9781 ccggcctgtt cgcagccagt ccaagggctg acggtcattg gatagggcat gattaaggaa
     9841 agacgttgct ggtttaggct cgcggcgcct tttttgcgtg ccgctgtact aattccagcc
     9901 agcaatacgt gtatgcgtcg agccagcaaa aaacaccagt gacacaacca tccgtagacg
     9961 attgtatcgc tggtgtttta gtcatgctag aaatgccgat ttaaagtttt ggcaatggca
    10021 tccatgtctt gtacccgttg taatcagcag tgtgcagtag cttttcggca tttgccaccc
    10081 gatcttgggt tggagactcg attccttcaa gccggtactt gatcttcatt tcatgatatt
    10141 ttttaacgcc caaagtatgg tacggcaata cttcgacttt ttgaacgacg tcgtttggaa
    10201 ttttagcaat gtaatcgccg agtttcttca agtcttcatc gtaatcagtc cgttggggaa
    10261 ccaggacgtg acgaatccac atatcatcgt ggtgttgggc catgtactga atcatatcca
    10321 agatattttc gttcccatac tgggtcaact gcttgtgttt ggcagaatcg atgtgcttaa
    10381 tgtcgaccaa cgaaatgtcc gtgaccttca ttagacgttc gaacttgtca aagaaaggtt
    10441 gttctcgggt aaaaggctgt ccagaggtat ccagacaagt actgatattc atcgccttgg
    10501 ctttttcgaa taagtccaag atgaagtcga tttgtaccag tgattcacca ccactgactg
    10561 tgatgccacc cgtcttgccc cagaaagccc ggtatttagc cgcgtcttcg agaatctcgt
    10621 cggccgtcat ttgatcgcca acgttgagtt tccaagtatc agggttgtga cagtattggc
    10681 aacgcatgtg gcatccttga aggaatgcca cgtaacggat acctggtccg tcaacggagc
    10741 caaacgtttc gatggagtga acgtagccta tcaaaggctc ctttgccgcc gcttgcgttg
    10801 ttgaaacttg tttgttttcc atgagccttt cgccttctta actattaaag attaaatgtt
    10861 acattgattc gaagaatgtc cgtgaaataa cgtcatcttg ttgttccttg gttaaatctg
    10921 cgaagtagac acagtagcca gaaacccgaa ccgttaatgt tgggtattct tcagggtgtt
    10981 tctgagcatc aatcaaagtg tctttattga agacgttgat gttcaagtgc atcccatcgt
    11041 tcttcatgta accgtctaac atgtttacta acgtgtcttt ccgtgattcg aggtcatggc
    11101 ctaacgtgtt aggggtaacg ccgaacgtgt tggaaatccc gtcagttgcg taacggtatg
    11161 gtaatttggc agttgaaaga agtgaagcta atgcaccact cttttcagca ccgtatgcag
    11221 ggttagcacc tggtgagaat ggttcgcctt tttgacggcc atttggtgtg gtaccagtgt
    11281 tcttaccata aacaacgttg gaggtaatcg tcaaaacaga agttgaaagt ttggcattcc
    11341 gatagaggtg atgcgtgttc atcttgctgt ataattcttt gactaaccat ttagcaatgt
    11401 catcagcgcg atcgtcattg ttcccataac gtgggtagtc attgtcggct ttgaagtcaa
    11461 cggcaatacc acgttcgtca cgaattactt taacgtgacc atacttgata gctgagattg
    11521 aatccgcggc atgtgataag ccagaaatcc cagttgcaaa ggtccgatca agatcagtat
    11581 tcttcaaagc taattgggca gcttcatagt agtacttatc atgcatataa tgaattgcat
    11641 tcagtgagtt aacgtaagtg tcagctaacc aatccatttg cttgtctaat ttcttcatga
    11701 attcgtcgta atcgatgtat tctgaagtaa ttggttcgta agcagggcca acttgatctc
    11761 cagcaatttc gtcgcggcca ccattgatgg cataaagaat cgctttggct aagtttgccc
    11821 gggcaccgaa gtactggatt ccatcagcaa ttggttgtgc ggaaacacag caagcaatgc
    11881 cataataatc ggtaccccat tgtacccgca tcaagtcatc attttcatac tgaatggttg
    11941 aactgtcgat tgaaacttca gttgcgtaac gtttgaagtc ttctggtaag cggtctgacc
    12001 ataaaatcgt gatgtttggt tctggtgcgg cgcccatgtt gtccaaagtc tttaaaatcc
    12061 ggaaagcagt cttagtcaca tggtgttgac cgtcgacgcc taaaccacac attgataagg
    12121 ttgcccagat tgggtcacca gagaagagag aattgtattc ttcagtacgg atgaaccgaa
    12181 ccatccgtag tttcatgacg aattgatcaa ttaattcttg agcttggctt tcgtccagaa
    12241 caccattgtc caagtcacgt tggatgaaga tgtccatcgt tgtatcaatc cggccaacgg
    12301 acattgcagc gccgttttgg gtcttgatag cagctaagta agcgaagtac atccattgaa
    12361 tagcttcttg agcattagtt gcaggcttgc taatatcgta gccataactg gcagccatct
    12421 tcttcatatc tgctaaagca cggtattgat cttgaacttc ttcacggagg cgaataacat
    12481 catcagtcaa ttcaccatca ccaatgtggg caaagtcatt agctttgtct tccattaaac
    12541 gatcgatccc ataaacagcg acccgtggaa gatcaggaat gagacggcca cgtgcgtatg
    12601 catctggtag tccggtgatg atcttgtagt gacgtgcttt ccgcatgtca ggagtataaa
    12661 catcgaagac gccttggtta tgagtcttgc gatattcagt gaaaatcttg tcgttttctt
    12721 catcaggggt ataaccgtat gatttcaaag cgtcatcagc cattcgaata ccaccaaatg
    12781 gcatgaaggc ccgcttcaaa ggcttgtcag tctggagacc aacaatcttt tcgagatctt
    12841 tttgaatata accagggccg tgtgaagtaa tcgttgcaac gactttagta tcagcatcca
    12901 acacaccacc agcggcacgt tcttgtttct ttaattctaa gactttgtca ttcaaggtct
    12961 tagtagcggc tgttggtccg gccaggaagc tttcgtcgcc attgtactgt gtgaagttat
    13021 tttgaataaa atcacgaatg ttgatttctt cctgccagtg cccgcctttg aaacctttcc
    13081 aagctgctgg ttttgttgtc ttttctgatg taatcatttt ctcgcctcca taatttgaat
    13141 ccaatcaaat gattgataaa attctatatt tgaatcataa cattttttgc tggatttgta
    13201 accgctttca ggtgatttat ttcacgtttg ggttattttt ttgcaatcta ttattgaaaa
    13261 gttgactatt aacgttgata taacagtact tacatagcta gataggcatt ggtaattcac
    13321 ttaattatat ttagaaaacg gctaaaaaca agactcgttt tgatatataa gtggaatatt
    13381 gtccataatg taacaagtgt ttaactagtt aattaataaa aagtgcaacg aggtgtggag
    13441 ggtgttaaaa gcgtttgccg ttgattttat gaggaagttc gttatcataa agaagataag
    13501 cagaaactag tgaatgtagt gaaaggtggg cgtaatgcgg atgctcgaaa aaattgaaca
    13561 atatattgac agttgtattg aagctggcga catttatggg gcgtcgttta gcttgatcac
    13621 ccctaaaggt atcaatcaat actatcatgg taagcagggc cgcgatgagt ttgccgtggg
    13681 cttagatcct gcgatgattt atgacctagc atcggtaact aaggttgtag ggaccacgac
    13741 gaggattttt cagttgttat cggaccacac gattcattta acggactcgg ttgcccggtt
    13801 tttacctggg ttcactcatc ctgaaataac gattaaaaac ttgttacttc ataatagtgg
    13861 gctaccggca gatattgata acctggataa gatgcaacgt gaagatctga tcaaagcggt
    13921 ttatgatgcg ccactcgtca cggcaccagg gacaacgtat gtctattcag acctgggatt
    13981 tattttattg ggatggatta ttcgtgcggt tgacggctca ttggctcgga gtattcaaga
    14041 ccacgtttgc tatccactag cgatgaccaa tacgggttat aacttaaatc gtccgaagat
    14101 tcggtttgtg ccgacggagt ttgatccgcg gcggggtcag attcaaggac aggtgcatga
    14161 ttataaagcc tttttgttga atggtgagag tggtcacgca ggcttgttct caacgctgac
    14221 ggatttatcc gtatttattg aaatgatgtt aaactttggt gaatatcaag gcaaacgggt
    14281 gctggatgaa aatgtctttg actggttagg cgagtatgac gaaaatggcc ggacgttagg
    14341 ttgggaacga cgtgcgggac gacatcaata tttccatact ggttttactg gcccggcagt
    14401 tgcttttgat ttggatcgtc aaattgggct ggttgtgtta acaaatcgag tttatccaac
    14461 tagtgacaat caggtctgga accaagatcg taagcgagta ttcgatctgt tttttgaatc
    14521 ctgatgatgg cagcttcatt aatagttagt agttaaatta aataagcgtc gcagccactt
    14581 aaggctgcga cgcttattta attacgattt catgacagct agaccgctga agtgtttggc
    14641 acttgtgggt gctaagcaaa cgctattttg ctttttgctt ctatatatac gttatttttg
    14701 caaccagcga agtccgggaa catgacgtgc aattttataa ccagcggcac cgataatgac
    14761 accagcccaa tttgtgatga catcatcgat atcaacccaa cgtttgaggt taaccaacca
    14821 gtcaaggatg aattgtccca gctcgagtgt tagccccgta agaaatccca accaaataaa
    14881 acgacgccaa ggcaagtcgg gaaaattcca tgccagtaaa ccgcccaatg gaacagtgag
    14941 gagaacgttg agccaaaatt caatgtcaag ttgttggaaa ggaatcacgt tcagcttaac
    15001 gggtccccat tgaatatatt gaataacgag ttgggtacca aaattgtaac tggtaggtgt
    15061 atagcaaaaa gcagttaaga cccagagaaa ggcaattaaa ctgagttgct taaaacgctg
    15121 gatatttgtg cgcactgatc gcgtacaagc gtatagtaga acaataaaca ttaatgaaat
    15181 caaaaagaat ggtagccaag ctagcataat ttagtcgctc ctttaattaa atagtataga
    15241 gaaaaaaagc tggtttgact attaataaaa agaaattcag aaaaagtgtt gacacttttt
    15301 acttcaattg gtatattagt aaacgttgct gctacggcag atgcatctca ccaccaaata
    15361 attattgaaa ttagttgttg acaatttctt cagtaattgg taagatagtt tctgttgtcg
    15421 caacggcaac tatgacaaat taatcaagtt acttcttaaa aaaaaagttg ttgacaagat
    15481 attgattaag atgttatgat gattaagttg tgttaagcga ttaacgcacg gaattagatc
    15541 tttgaaaact gaacaaagtt
//
