LOCUS       gnlProkkaBICEFGKB_29   13919 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BICEFGKB_29.
ACCESSION   gnlProkkaBICEFGKB_29
VERSION     gnlProkkaBICEFGKB_29
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:27:44
            Original ID  :: gnl|Prokka|BICEFGKB_29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13919
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13919
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1132:3919]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1133..3919
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..13919
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13919
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(2..88)
                     /locus_tag="ctg29_1"
                     /transl_table=11
                     /translation="MTQFTTELLNFLAQKQDIDEFFRTSLETA"
     CDS             332..487
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_2"
                     /sec_met_domain="L_biotic_A (E-value: 3.7e-28, bitscore:
                     87.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 4.6e-08, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       332..406
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MEKETTIIESIQEVSLEELDQIIGA"
                     /locus_tag="ctg29_2_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       407..487
                     /prepeptide="core"
                     /locus_tag="ctg29_2_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKETTIIESIQEVSLEELDQIIGA"
                     /leader_location="[331:406](+)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     CDS             952..1113
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_3"
                     /sec_met_domain="L_biotic_A (E-value: 2.4e-26, bitscore:
                     81.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNNKICQDALESLQELKLEEVDELLGGAGHGVNTISAECRWNS
                     LQAIFSCC"
     CDS_motif       952..1038
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKNNNKICQDALESLQELKLEEVDELLGG"
                     /locus_tag="ctg29_3_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1039..1113
                     /prepeptide="core"
                     /locus_tag="ctg29_3_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.40"
                     /molecular_weight="2495.8"
                     /monoisotopic_mass="2494.2"
                     /core_sequence="AGHGVNTISAECRWNSLQAIFSCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNNNKICQDALESLQELKLEEVDELLGG"
                     /leader_location="[951:1038](+)"
                     /alternative_weights="2513.8"
     CDS             1133..3919
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     689.6; E-value: 1.2e-208)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_4"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-82, bitscore:
                     267.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.7e-54, bitscore:
                     174.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQKEQLYSQFDKFPKVVIERLIPEVLNESDSLIKQIEEKISDYY
                     RSTLIYLINEKRINGTLVGETAELRYDFFNNVLCRNGTILDEIEERFPKINQRVFISIK
                     HYLDLLNCVKKHFVSDFLELKKLKFLKSNDESPDLNVLDIKVTGDIHNGSGVCILDYNR
                     QKLVYKKKSSRPNILLKELDSQASNYLKKEIRFIPDFLDKNEYFWEVFVESKPVSSLKE
                     ANEFYKRMGYLLVYSYILNISDLHFENLISHSIQPILVDAETVFSTNPYETVAENDATL
                     KIVENSRNSVLSTGLLPISEADKIFGGDTSGVLGGTLIGEAKVIINHNRDDIHVEKQKY
                     KTENQNHLPYFENNLGIKTYLNAEEYVEYIKEGFIELSKFIINNKEALKKLYLSFSDIK
                     TRVLFRNTRDYSLVRQLLLSPVYCNQDNILFEKMSNKLTNYDSHNLCQSEVKQLLNMDI
                     PYFYVCASDINVKDKDGNTNIWKLKKSSLSDTIEKLEKFDLDTMEEQLDLVEFSIKTPN
                     ALYSTELQESYKIFQNSNSNHSILFTGINTIVDTILKNEKFSKLDGSTNWLTLKVTDYD
                     AFQLEPMDSSIYEGIAGLSIALCEVYKLVDDDRQQRIYNCLRRIFMTLMKAYYSTQNQS
                     YYVGKLGILSAMIRIQSITGQEIPVSIFDINNKYILDLNVQSADFLSSFPSEIVALRNS
                     NVSIGNLQQSFEKLVDLKIISEDYIAWDKLESNNVSLAHGNLGIELGLLYLAVALNSSE
                     AVELFYQATNFDSHQKLSNGWIDKRNNSTSANWCHGSTGVLAARLAQLQLDKKFHIISK
                     TKRSELEADMKHAASQIIEIGFDMTNFSICHGTSGNLLALSYYCSYLSGNEREELEKIL
                     DIEYRKLHSFGLENGWMCSFNTKYNVYGIMNGLSGILYSTAKYLKKDDSLDILIPTL"
     CDS             3946..6018
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 128.8; E-value:
                     4.3e-39)"
                     /gene_kind="transport"
                     /locus_tag="ctg29_5"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.7e-39, bitscore:
                     123.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDSLPADGLN
                     VSYLLSLNKRFGVALKAYHASFRDLLQVYNEKKQRIILHWNQDHFVVLDKITEKQVTIV
                     DPAIGRVKYSHDEFLNHYSETIVLINKDENFQTQKYKQIFWKYFKLTLKTKTIILFLLS
                     LVLIQISVLAFSILLRYMLSEKFQFLSNILVLFGVVLFQLLGYFIKNSALNEYNLDFDD
                     NYSKALFQKLLKKPLLYFRNHLSGGISEKINFKSTLRDNVTLKIIPSCVSFISAIVIFT
                     YLITISVRLTIILIIIILVYSVISIILYRKQNEYNQTYLQYLIDFNSELQTDLDDIDYI
                     KIMRREGLTFASWMKINQQVTEKYSQILKFENLSQLVSTIFNYISLSVIIVIATYYNKY
                     IKVSISDLLVYQTSISLLISAIEQVKGAVFEVVKLGIYAEKQSDLLKDSRPILVQSSDS
                     DEYLIKAESLNFSYGMSPIYKDINLTINRGEKIAIIGKSGSGKSTLLLLLAGMLRFSGS
                     LKYGIKNFEDSLSVVLQNMTLRKGSVLENLEWDTDNLEPLYQVLKDTSADEVIAQLPNK
                     IHSKLLKQGKNLSGGQIQKMLIAKSLLKKNSIIFWDEAFSNLDEQSKNRIYLNILQNSQ
                     YSERTMLIVSHHLDIVDYVDYVIYIDNEMGDVYKDTHINLMESNENYRNFINSKI"
     CDS             6122..7033
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.8; E-value:
                     7.9e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg29_6"
                     /transl_table=11
                     /translation="MMNNIIELKKVKKVYKDITTVDIEKITVREGEIYGFLGPNGAGKT
                     TTMKMILSLVDPTSGEIFVNKKDIRKDKNYLSQIGSMIEEPSYYPNLTGYENLLVFQKM
                     VGFDENNIWPTLELVGLADEKNRKKLVKAYSLGMKQRLSLAFALVKKPKILLLDEPTNG
                     LDPAGIHEIRELIVELAKEKGLTVFISSHILPEIEHIADRVGIINHGRLVYEGEIEAIK
                     SNTWIEIGGDFSQSNIVHTLVELGTVEILGASTSHVKLSNIDNNQLANVVSYLTENGYR
                     IFRVVRESETLEDIFLSLTKEA"
     CDS             7035..7799
                     /locus_tag="ctg29_7"
                     /transl_table=11
                     /translation="MIKVLQIELLKSKRTKSFMISFLMMFVAVTWSLLAASRSIGVPKL
                     RTIGLFFNNLQATPIFLPIAISLFVSRIVSNEKEGNTFKLQEANNINLITIFKRKLIFT
                     NTIFLLLNVVQVLIVYLYAVRYGIDVAVSNLLLQVVGLTMSSFTLITFFLFLSMILEKH
                     GMVLGIGFVSGFLGMVLSEASKWLNLIFPFGGSSFLALYRIKVLHSGDKLDYIFVWDKS
                     VPLNYLIYLFYCIFVYFIIKYLLVKKKEENYD"
     CDS             7862..8599
                     /locus_tag="ctg29_8"
                     /transl_table=11
                     /translation="MIDYFKAEWIKNRKVVILAIGLIFLALSSFIGLANFFLNYDVLIE
                     EQMSRVLWGQLTFYNGQLLFPAMLAIFSGLIILPEFERKTLEMLRANQASVKKMVLSKF
                     LLALFLVSVVQAVLFAIYLLTLYLSQIPFQIEDLLLFLRATILSVIGSSSVLMIHSYLM
                     AKTRNFAKSVGVAAIGSFSGFIFIMLGGFINQLFPYSQPMIGLRSRALNDMSFLEFMLF
                     ITVNSLYSFIFYWLTVKKLENNE"
     CDS             8879..9103
                     /locus_tag="ctg29_9"
                     /transl_table=11
                     /translation="MYQRIRDLREDHDFTQRFVANLLSFSHTNYAKIERGEVALTADVL
                     VQLSKLYNVSTDYLLGLTDYPDRIKHKIK"
     CDS             9144..9251
                     /gene="allorf_09144_09251"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_09144_09251"
                     /protein_id="allorf_09144_09251"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGLSYLSSNLVRYAVIGAKIISYKIEWFSICHNHK"
     CDS_motif       9144..9197
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MGLSYLSSNLVRYAVIGA"
                     /locus_tag="allorf_09144_09251_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9198..9251
                     /prepeptide="core"
                     /locus_tag="allorf_09144_09251_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="2110.5"
                     /monoisotopic_mass="2109.1"
                     /core_sequence="KIISYKIEWFSICHNHK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGLSYLSSNLVRYAVIGA"
                     /leader_location="[9143:9197](+)"
                     /alternative_weights="2128.5"
     CDS             9564..11318
                     /locus_tag="ctg29_10"
                     /transl_table=11
                     /translation="MKTNNVEIIKADSLVRRRGVNVERHLKRVAAYCRVSSDSEDQKNS
                     YESQVKHYKDYISQRSDWELADIYADEGISGTQVGKRQDFQRLINDCVNGEIDYIVTKA
                     IARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVENTSA
                     HVKKGLKMKMQRGELIGFQGCLGYDYDVETKQLSINKKEAKIVRYIFERYLEGIGGKVI
                     ARELDELGYKSPRGLDHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSNFGEED
                     KYYIKDNHEPIISKEDFEKAQEIRLRRAGNKKTVANVNGKRERYSKMYAFSSMLECGFC
                     GSLLSRRSWHCRSDYRKVVWHCVTSIKKGKKYCKHSKGLEELAIEGAFMEAYRQLYHSN
                     ENIVSDLLETIESELNDNSLNKELKKITNKLRTLLKKEENLVNLKLEGKISDSIYNEKY
                     NELSLEKEYLAEEKVNVETTLKSEIDVKKRLTEFKQLLSSQKMLTEFDRTVFESIVEKI
                     IVGGVNSDGEIDPAMLTIIFKTGETQNKDGKQFKSKRKNAKLESDELCPQNCDEDKKLY
                     SQGIDNTC"
     CDS             complement(11602..11676)
                     /gene="allorf_11602_11676"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_11602_11676"
                     /protein_id="allorf_11602_11676"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKSKYSLLEAIIYTSKICIGLQDF"
     CDS_motif       complement(11635..11676)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKSKYSLLEAIIYT"
                     /locus_tag="allorf_11602_11676_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(11602..11634)
                     /prepeptide="core"
                     /locus_tag="allorf_11602_11676_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="1105.3"
                     /monoisotopic_mass="1104.6"
                     /core_sequence="SKICIGLQDF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSKYSLLEAIIYT"
                     /leader_location="[11634:11676](-)"
     CDS             11736..11876
                     /locus_tag="ctg29_11"
                     /transl_table=11
                     /translation="MPNAKYESPYDGANEMLLVDDVDNKNYLTGLFNAMYDELPAPKPK
                     K"
     CDS             12108..12452
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 63.3;
                     E-value: 4.5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_12"
                     /transl_table=11
                     /translation="MQPVGSIGLMIGSASDKGIPDAEAEVGYWIGVLYWGQGLIPEAVR
                     EIMRHGFDDLNLEKMWFGYFDGNTKSKRVQEKCGFRYHHIKEKVPCALEGVFSTEHIAC
                     LSKAEWISIK"
     CDS             12632..13198
                     /locus_tag="ctg29_13"
                     /transl_table=11
                     /translation="MVILELYQGDYQKDLVAFDSLEEGRAFVAQIPGYTLETEDGFGVE
                     FVNPKYLPDYMEIVFNGNIVPLSRFSFNSEENVDIIWKEISNLSVKNDKVIEGYSKIDA
                     YVVNNDEVKAYVEAREANYRKAKDFLERCGYEADRSFFGSEDGEAILYRKKGTEDWKFL
                     CHLDPLFVEIEDVEGYVKEEIQLLN"
ORIGIN
        1 tagctgtttc aagagaagta cggaaaaatt catcaatatc ttgcttttgg gctaggaagt
       61 taagtagttc tgtggtaaac tgagtcatag gaataaatct ctttctagta atgttttgca
      121 actctactat aacggattta ttcctttttg tgtttacaca acttatttta cactaccagt
      181 aaaatcaaag atttaaaatc tttaaaataa ctttatgatt tctttaatat atcttaaagt
      241 caactttgta aaatttactt gtaacaaaga taaagacact tggtctcaaa ataagaacgg
      301 cactcaaata aaattaagaa aaggataaat tatggaaaaa gaaacaacaa ttattgaatc
      361 aattcaagaa gttagtcttg aagagcttga ccaaattatc ggtgcaggaa aaaatggcgt
      421 atttaaaacc atttcgcacg aatgtcacct aaatacatgg gcgtttcttg ccacatgttg
      481 ttcttgattt tggatgacta agtgtctaat atgttacatt aaaaaaggag ggaaacctct
      541 tttttatatt cagaaatttt aattcttaaa gataatagaa ttgcttatcg aaaaatagaa
      601 tctaggagta aagatttgta aagtattttg tgtcaagacg agattctacc cactaaatat
      661 tctccgttgt attcactaaa gtttacgatt taatgatgaa ggataaaatg tgatgtgtat
      721 ttaaagaaag tatatgattt acaacttatg taaaaaatat taagaagagg tataaattag
      781 taatgtgaag ttactttatc cttgtttgat tctgaactaa caagatttat caataaatta
      841 acattagctt tagattagct ttaacttttc tttatgttgc gattttaaaa ttaaagcata
      901 aataaaaata ttttcgagtt atgctcggta taacatatga ggtgataaat tatgaaaaat
      961 aataataaaa tttgtcaaga tgctttggaa tccttacaag aacttaagtt agaagaagtt
     1021 gatgaacttt taggtggagc aggccatgga gtaaatacta tttcagcaga atgtcgttgg
     1081 aatagtttac aagcaatctt ttcatgttgc taatttttag agaggtaata ttatgaatca
     1141 gaaagagcaa ctatatagtc agtttgataa atttcctaaa gtagtaattg aaaggctcat
     1201 ccctgaagtt ttaaatgaaa gtgactcgct aattaagcaa attgaggaaa aaatttcaga
     1261 ttattataga tctacattga tttatttaat taatgaaaag cgcattaatg ggacattggt
     1321 tggtgaaaca gcagaacttc gatatgactt ttttaataat gtattatgta gaaacggtac
     1381 tattttagat gaaatagagg aacgatttcc taagattaat cagcgtgtat ttatcagtat
     1441 taaacactat ttagacttac taaattgcgt gaaaaagcac tttgtgagtg atttcttaga
     1501 attaaaaaaa ttaaaatttt taaagtctaa tgatgagagt cctgatttaa atgttttaga
     1561 tataaaagtc acaggagata ttcacaatgg aagcggagtc tgtattctag attataatag
     1621 acaaaaattg gtttataaga aaaaatcatc aagaccaaat attcttttaa aagaattaga
     1681 tagtcaagca agtaattatt tgaaaaagga aattaggttc attcctgatt ttttagataa
     1741 aaatgaatat ttttgggaag tatttgtcga gagtaagcca gtatcctcac ttaaagaagc
     1801 aaacgagttt tataagagaa tggggtatct tttagtttac tcctatattc ttaatatctc
     1861 tgatttacac tttgaaaatc ttatatctca tagtatccaa cctatattag tagatgctga
     1921 aactgttttt tcaactaatc catatgagac agtagctgaa aatgatgcaa cattaaaaat
     1981 tgttgaaaat agtcggaatt cagttctttc tacgggatta ttacctattt ctgaggctga
     2041 caaaattttc ggaggtgata cgagtggtgt tttaggagga acgcttattg gtgaagcaaa
     2101 agttattata aatcataata gagatgatat acatgttgaa aaacagaagt acaagactga
     2161 aaaccagaat cacttaccat actttgagaa taatttggga ataaaaacgt atttaaacgc
     2221 tgaagaatat gtagaatata ttaaagaagg cttcatagaa ttaagtaaat ttattattaa
     2281 taataaggaa gcattgaaga aactttactt aagttttagt gatataaaaa cacgtgtttt
     2341 atttagaaat actagagatt atagtctagt tagacaatta ttgctttcac cagtttactg
     2401 caaccaggat aatattttgt ttgaaaaaat gtcaaataaa ttaacgaact acgatagtca
     2461 taatttatgt caatctgaag taaaacaact tttgaacatg gatattccgt atttttacgt
     2521 ttgtgcaagt gatattaatg ttaaagataa ggacggtaat actaatattt ggaaactaaa
     2581 aaaatcttca ctgagtgata caattgaaaa attggaaaaa tttgatttag atactatgga
     2641 agaacagtta gatttagtag aattttcaat taaaacccca aatgctttat acagtacaga
     2701 gttgcaagag tcatataaaa tttttcaaaa ttcaaactca aatcatagca tattatttac
     2761 tggtattaat actatagttg atacaatttt aaaaaatgaa aaattttcta aattagatgg
     2821 aagtacaaat tggttaactt tgaaagttac agactatgat gcatttcaac tagaacccat
     2881 ggattcatca atttatgagg gtattgcagg actgtctatt gcgttatgtg aagtttataa
     2941 attggtcgat gatgatagac aacagagaat ttataactgt ttacgcagaa ttttcatgac
     3001 tttaatgaag gcttattatt ctacacaaaa tcaatcgtat tatgttggca agttaggaat
     3061 tttatctgca atgattagaa tacagtcaat tactggtcaa gaaataccag tatctatttt
     3121 tgatattaat aacaaatata tcttagattt gaatgttcag agtgcagatt ttctatcaag
     3181 ttttcctagt gagattgtag ccttacgaaa tagtaatgta tcaattggaa atcttcaaca
     3241 atcttttgag aaattagttg atttgaaaat tatttctgaa gattatattg cgtgggataa
     3301 attggaatct aataatgtta gtttagcaca tgggaattta ggaatagaac tgggattact
     3361 ttatcttgcg gtggcattga atagttctga agcagtggaa ttgttctatc aagctacaaa
     3421 ttttgatagt catcaaaaat tatcaaatgg atggatagat aaaagaaata attcgactag
     3481 tgctaattgg tgtcatggtt ctacaggggt gttagctgca agattagctc aattacagct
     3541 ggataaaaaa ttccatatta tatctaaaac aaagagaagc gaattagagg ctgatatgaa
     3601 acatgcagca tctcagataa ttgaaattgg tttcgatatg acaaattttt ctatttgtca
     3661 tggaacaagt ggaaatttgt tagcacttag ttattattgc tcgtatctat caggaaatga
     3721 aagagaagaa ttggaaaaaa ttttagatat agagtataga aaattacatt catttggttt
     3781 agagaatgga tggatgtgca gctttaatac taaatataat gtttatggaa taatgaatgg
     3841 tttgtcagga attttatatt ctacagcaaa atatttaaaa aaagatgatt cgttggatat
     3901 tttaatccct actctttaaa aagagataga aaggaaaact caagtatgaa gattatttta
     3961 caaaacaacg aagaggattg tctgttagcg tgttacacaa tgttattaaa tgatttaggt
     4021 cataaagttc cactatatga agtatacgat aaagactcat taccagcaga cggacttaat
     4081 gtatcatact tgctatctct aaacaaaaga tttggagtag ctttgaaggc gtatcacgcg
     4141 tcgtttagag atttattaca agtctacaat gaaaaaaagc aaagaataat tcttcactgg
     4201 aatcaagatc atttcgtagt attagataaa attactgaaa aacaagttac gattgtagat
     4261 cccgctattg gtcgtgtaaa atacagtcat gatgagtttc taaaccacta ttctgaaact
     4321 atagtgttaa taaataagga tgaaaatttt caaactcaaa aatacaaaca gatattttgg
     4381 aaatatttta aacttacttt gaaaacaaaa acaattattc tatttttgct ttcgttggta
     4441 ctaatccaga taagcgtttt agcattttct atcttattaa gatatatgtt atcagaaaag
     4501 tttcaattct tgtcaaacat actagttcta tttggtgttg ttctttttca actattaggc
     4561 tattttatta agaatagtgc cttaaatgaa tataacttag attttgatga taactatagt
     4621 aaagcacttt tccaaaaatt gttaaaaaaa ccactattat attttagaaa tcatttaagt
     4681 ggcggtattt cagagaagat aaatttcaag tctactttaa gggataatgt gacattgaag
     4741 attatcccct cttgtgtaag tttcatctca gcaattgtta tttttacata tttaataaca
     4801 atttctgtaa ggttaacaat aatcttgatc ataataattt tggtttacag tgtaatttct
     4861 attatacttt atcgtaaaca gaatgaatat aaccaaactt atctgcaata tttgattgac
     4921 tttaattcag agttacaaac agatttagat gatattgatt atatcaaaat aatgagacga
     4981 gaaggtctaa cttttgcatc gtggatgaaa attaatcaac aagttactga aaaatattca
     5041 cagattttaa agtttgaaaa cttatcacag ttagttagca cgatttttaa ttacattagt
     5101 ttgtctgtaa ttatagttat agcgacttac tataataaat atattaaagt atccatctcg
     5161 gatttactag tctatcaaac aagtatttca ttattaatat ctgcaattga acaagtgaag
     5221 ggtgcagttt ttgaagtagt aaagttgggg atatatgctg aaaaacaaag tgatttatta
     5281 aaagatagta gaccaatttt agtacaaagt tcagattcgg atgagtattt aattaaggct
     5341 gaaagcctaa atttttctta tggcatgagt ccgatttata aggatattaa cttgacaatt
     5401 aatagaggtg aaaagattgc aatcataggt aaatcaggta gtggaaaatc aacgttacta
     5461 ttacttttag cgggtatgct acgatttagt ggatcgttga aatatggtat taaaaatttt
     5521 gaagatagtt tgagtgttgt tctacagaat atgacattaa gaaaaggaag cgtgttagaa
     5581 aatttagaat gggatacaga taatttagag ccattgtatc aagtattaaa agatacttca
     5641 gctgatgagg ttattgccca gttaccaaat aaaattcatt caaagttatt gaaacagggg
     5701 aaaaatttat ctggaggaca gattcaaaaa atgttaattg ctaagtcttt attgaaaaaa
     5761 aactctatta ttttctggga tgaagctttc agtaatcttg atgaacaaag taaaaataga
     5821 atctatctta atattcttca gaacagtcaa tactctgaaa ggacaatgtt gattgttagt
     5881 catcatctag atattgtcga ctatgttgac tatgttattt acatagataa cgaaatgggt
     5941 gatgtttata aggatacaca tattaatctt atggaaagta acgaaaacta tagaaatttt
     6001 attaattcaa aaatttgaga cttgcgttat acattcttaa tgttatcttt aagatgaaca
     6061 ggtacaatta ttaatgtaaa gaaaggagta gtctaataaa atagattgct aaaggataat
     6121 gatgatgaat aatattattg agctgaaaaa agtaaaaaaa gtttacaaag atattactac
     6181 tgtagatatt gaaaaaatta ctgtacggga gggagaaatt tatggttttc tagggccaaa
     6241 cggtgctggg aaaacgacaa cgatgaaaat gattctatcc cttgtagatc cgacttcagg
     6301 tgagattttt gttaataaaa aagacattcg aaaagacaaa aattacctga gtcagattgg
     6361 atctatgata gaagagcctt catattatcc taatttaaca ggttacgaaa atttattagt
     6421 gtttcaaaaa atggtgggat ttgatgaaaa taatatctgg ccaacattag aacttgttgg
     6481 attagctgat gaaaaaaatc gaaaaaaatt agttaaggcc tattctctag gtatgaaaca
     6541 acgtctttct ttagcgtttg cattagtaaa aaagcctaaa atcttattat tagatgagcc
     6601 tactaatggt cttgatccag caggtattca tgaaattcgt gaattgattg ttgagttagc
     6661 caaagaaaaa ggtctgacag tctttatttc tagtcatatt cttccagaaa ttgaacacat
     6721 tgcagatcga gtgggtatta tcaatcatgg tcgtctagtt tatgaaggag aaattgaagc
     6781 tattaaatca aatacctgga ttgagattgg tggtgatttt tcacagagta atattgttca
     6841 cactttagtt gaactaggga ctgtagaaat tttgggtgca tccacaagtc atgtaaaatt
     6901 aagtaatatt gataataatc aattagctaa tgtggtgagc tatttgacag aaaacggata
     6961 ccgtattttc cgagtggtta gagaaagtga gaccctagaa gatattttcc tttcgttaac
     7021 gaaggaggct taaaatgata aaggtattac aaatcgaatt attgaagagt aaacgaacaa
     7081 aatcatttat gatatcgttt ttgatgatgt ttgtagcagt aacttggtca ttactagcag
     7141 catcaagaag cataggtgta ccaaagttaa ggacaattgg attatttttc aataatttac
     7201 aagctactcc tattttttta ccaattgcga ttagtctttt tgtatcccga attgttagta
     7261 acgaaaaaga aggaaataca tttaaactac aagaagcgaa taatataaat cttataacca
     7321 ttttcaaacg aaagcttatt tttacgaata ctatttttct attattgaat gtagtacaag
     7381 tattgattgt atatttatat gctgttagat acggtataga tgttgctgtt tcaaatttac
     7441 tattacaagt tgtaggtttg acgatgtcta gttttacttt aattactttt tttctatttc
     7501 tatctatgat attagaaaaa catggtatgg ttttaggaat tggatttgta tcagggtttt
     7561 tagggatggt tctatccgaa gcatctaaat ggttaaatct aatctttcct ttcgggggtt
     7621 caagttttct tgcactttat cgcataaaag ttttacattc tggagataaa ttagattaca
     7681 tatttgtttg ggacaagagt gtaccactca actatcttat ctatctattt tattgtatat
     7741 ttgtctattt tattattaag tacctattgg ttaaaaagaa ggaggaaaac tatgattgat
     7801 tattttaaag ctgagtggat taagaatcgt aaagtagtgg ttaaaaagaa ggaggaaaac
     7861 tatgattgat tattttaaag ctgagtggat taagaatcgt aaagtagtta ttttagctat
     7921 tggtcttatt tttcttgctt tgtccagttt tattggatta gctaattttt tcttgaacta
     7981 cgatgtgttg attgaagaac agatgagtag ggttctttgg ggacagctga ctttttataa
     8041 cgggcagtta ctttttccag ctatgttagc tatattctca ggtctaatta tccttcctga
     8101 atttgaacga aaaacacttg aaatgctacg agctaatcaa gcatcagtta agaagatggt
     8161 actaagtaag tttttattag ctttgttctt ggtatctgta gttcaagcag tgctgtttgc
     8221 tatctattta ttaactcttt atcttagtca aattccattt cagatagagg atttattatt
     8281 atttttgaga gctacaatat tatcagttat tggttcaagt tctgttttga tgattcacag
     8341 ttatcttatg gcaaaaacta ggaattttgc taaatcggtt ggagttgcag caattggttc
     8401 cttctcaggt tttattttta ttatgctagg tggttttatt aatcaattat ttccatattc
     8461 tcagccgatg attggtttac gaagtagggc attgaatgat atgtcatttt tagagtttat
     8521 gttatttatt acagtgaact ccttgtatag tttcattttt tattggttaa ctgttaagaa
     8581 attggagaat aatgaataac gtgatgataa attttttgtg tagttcttca acatagtaga
     8641 taaaatgaaa ctcagatcca taaaataatc gctatgctga ttttcgattt gttcttgaaa
     8701 tgatagtaag cctgatttac gtaaagaata gaacaacaac tttcttgcaa aattaaatga
     8761 taaatttgca cgagctatta tcataattac aggaatgacg caataattac tgtcatatta
     8821 tgacaatttc ccagcttttt tctgaaagtg acatatactt ttcttaggag aaagctatat
     8881 gtaccaacgg ataagggatt tgagggaaga tcatgatttc actcaaaggt ttgttgcaaa
     8941 tttactttcc ttctctcata caaattatgc aaaaattgag agaggagagg ttgccttaac
     9001 ggcagatgtt ctagtgcaac tttctaaact ctataacgtt agtacagatt acctattagg
     9061 gttaacagat tatccagata ggataaaaca taaaataaaa tagtctctcc ttgatttgtt
     9121 cattgacaat tgaataaacc gaggtgggac tttcttattt gtcgagcaat ttagtgagat
     9181 acgccgtgat aggagcgaaa attattagct ataaaataga gtggttctct atctgccata
     9241 accacaaata aggacaatga tacttctgaa cgttcaggct gccatcgtaa aaggacagcg
     9301 ggtgaaatgc ccatgaatga tttaaccaat catacctact gaggaaatta tagagtaaca
     9361 cgttatcagg aggaaaagtt ttggaacaat cagtagtaat atatagtatg caattatcaa
     9421 tgcttaactt tttatactca agaaatatgc tatctaaaaa tgagtatgaa aaaatcagaa
     9481 acaaactgcg tattaagtac acaaaatagc tgaccttttt atttgaacgc ggtaatatag
     9541 aatcaaaagg aggaatttca gttatgaaaa caaataatgt tgaaataata aaagctgatt
     9601 ctttagttcg acgtagaggt gtcaatgttg aaagacattt aaaaagggtt gctgcttatt
     9661 gccgagtgag ttctgatagt gaggatcaga agaacagtta tgaatctcag gtgaaacatt
     9721 ataaagatta catttctcag cgttcagatt gggaactcgc tgatatctat gcagatgagg
     9781 ggatttcagg aactcaagta ggaaagagac aagattttca acgcttaatc aatgattgtg
     9841 taaatggaga aattgattat attgtaacaa aagcaattgc tagatttgca agaaacacct
     9901 tagatacttt gaagtatgtc agaatgttaa aggatatgca aattggagta tattttgagg
     9961 aagagaacat tgataccctt actatggatg gagaattact tctaaccatt cttagctctg
    10021 ttgcacagca agaagtagaa aatacatctg cacatgtgaa aaagggatta aaaatgaaga
    10081 tgcaacgtgg tgaactgata gggtttcaag ggtgcttggg gtatgactat gatgtagaaa
    10141 ccaagcaact ttcaatcaat aaaaaagaag ccaaaatagt tcgttatatc tttgaaaggt
    10201 acttagaagg tattggaggg aaagtcatag caagggaact tgatgaacta ggttacaaat
    10261 cgccgagagg attagatcat tggaatgata caacagtctt aggaatcata aagaatgaaa
    10321 aatataaagg cgatattcta atgggcaaaa cttttacagt ggatccaata agcaagagac
    10381 gtttaagtaa ttttggtgaa gaagataagt actacatcaa agataatcat gaacctataa
    10441 tatctaaaga agactttgag aaagctcagg agattaggtt gcgtagggca ggaaataaaa
    10501 agacagttgc gaatgtaaat ggaaaacgtg aacgctattc aaaaatgtat gcttttagta
    10561 gtatgttaga atgtggtttt tgtggttcat tattgtctag gagaagttgg cactgtcgtt
    10621 cagattatcg aaaagttgtg tggcattgtg ttacttcgat aaaaaaaggg aaaaaatact
    10681 gtaaacatag taaaggatta gaggaactgg ctattgaggg agctttcatg gaagcatata
    10741 gacaactcta tcattcaaat gaaaatatag tgtcagattt acttgaaacg attgaatctg
    10801 aattaaatga caatagcctc aacaaggaac tgaaaaaaat aactaataag cttcgtactt
    10861 tactaaaaaa agaggagaat cttgtaaatt taaaactaga aggaaaaata agtgattcaa
    10921 tttataatga aaaatataat gagctctcct tagaaaaaga atatcttgca gaagaaaaag
    10981 taaatgttga aacaacattg aagtcagaaa ttgatgttaa gaaaagacta actgagttta
    11041 aacaattact gtcttcacag aaaatgctca ctgagtttga tcgtacagtt tttgagagca
    11101 tcgttgagaa aattattgta ggtggtgtta atagcgatgg tgaaattgat cctgcaatgt
    11161 taactattat tttcaaaaca ggagaaacac aaaataagga tggcaaacaa ttcaaaagta
    11221 aacgtaaaaa tgctaaacta gaatcagatg aattgtgtcc tcaaaactgt gacgaggaca
    11281 aaaaattgta ttctcaagga atagacaaca catgttgagg cggtatcact acttgtacga
    11341 gctgagactt cagcgaagta gaagtagatg ctccgcccat gcgatagctg tcgtagagta
    11401 aggagtttac gacgaaacga tacggtaata gcgaaccgcc gagtgtgtga gtttttagtg
    11461 aaacgtagct aatcctcaaa aggttctccg aaccttttga gtcccacgga cgcatcatgt
    11521 tgaatgcgta acactgcttg tacgagctac gaagtagcat agtagaaacg gaaggcccac
    11581 catattgaac taatataagt attaaaaatc ctgtagacca atgcaaattt tggaggtgta
    11641 gattatggct tcaagcaaag aatatttaga tttcattatt gtgaatttat gatgatagat
    11701 ttttagtgaa gccttttaaa tctgcaatag catatatgcc aaatgcaaag tacgagtcac
    11761 catatgatgg agcaaatgaa atgctgttgg tagatgatgt tgacaacaaa aattatttaa
    11821 ctggcttatt caatgcaatg tatgatgaat tacctgcacc taaaccaaag aaatgatcag
    11881 agtggaattt aaggagaaaa aacgatttta gaaacggaaa ggttgattct tcgcccatgg
    11941 gaagaaagag atgccaatga tttattccaa tatgccagta atccagaggt tcagagattg
    12001 gtccgattgc aggttggcca gtacatacta gtgttgaaaa cagtagggaa attataaaaa
    12061 gttatttttc cgcacctgag acatacgcta tagttttaaa agaaacaatg cagccagtgg
    12121 gtagcatagg tttgatgatt ggctctgcaa gtgataaagg tattcctgat gctgaggcgg
    12181 aggttggtta ctggatagga gttctgtatt ggggtcaggg gcttatacca gaagcagttc
    12241 gtgagataat gagacatgga tttgatgact tgaatttgga gaaaatgtgg ttcggttatt
    12301 ttgacggcaa tacaaagtca aagagagttc aggaaaaatg tgggttccgt tatcatcata
    12361 taaaagagaa ggttccatgt gcattggaag gtgtttttag cacagaacac atcgcctgtc
    12421 tctcaaaggc agagtggatt tcaattaagt aaatcttagt ttgttgaggt cataccttta
    12481 aatgataacc ttatgcgatc gttaaaagct ctatagacct gtttctacat acagataggt
    12541 tcactcgttt catgttgatg tagtatcact gcttgtaaga tttgaaaaat aaatttgcgt
    12601 agcgtcgtaa aggttaaatg gagggttatc gatggttata ttggaattgt atcaaggtga
    12661 ttatcaaaag gatttagtcg cgtttgattc tttagaagag gggagagcgt ttgtagctca
    12721 aatcccgggg tatactttag aaacagaaga tgggtttggg gtggagtttg tgaacccaaa
    12781 atacttgccg gattatatgg aaattgtctt taacggaaat attgtccctc tatctagatt
    12841 ttcgtttaat tctgaagaaa atgtggatat tatttggaaa gaaatttcga atctatccgt
    12901 taaaaacgat aaagtgattg aaggatattc aaaaatcgac gcgtatgtcg ttaacaacga
    12961 tgaagtgaaa gcctatgtcg aagcaagaga agcgaactat cgcaaggcaa aagactttct
    13021 agaacgctgt ggatatgagg ccgacagaag ctttttcgga agtgaagacg gcgaagcgat
    13081 tctctataga aaaaaaggta ccgaagattg gaaattctta tgccacttag acccactatt
    13141 tgtagagatt gaagatgtag aaggatatgt caaagaagag attcagttgt taaactaaag
    13201 aatgttgcga aggcgtggcg tgagttatat ttaaaaaggc ttctattttg ccagatggtg
    13261 gaattaagga gaaatttatg accttaaaac aaattaaatt taattctttt aaacactggg
    13321 gaatcatcag cgacttgtat aagcagtcct ttccaaagga ggagcgaatt cccttctttg
    13381 gacttggctc ttatcattga gaaaaatgga tttacactgt gtccctgtct cattcgtgaa
    13441 ttaggcgttg actttgctct tatgagccag acagggcaac taattccatt cgactatcag
    13501 gatatctttg acaatttctc ttttggactt ggagatgtat caatttgttc gataaattaa
    13561 taaaacgtac cttaccaaaa ttgtactgaa ctaaaaaatt atctaattga gaaaagaaca
    13621 aaagttttgg tctataatat agatattttc tagcatcaca tgtggaggca gtctcactgc
    13681 ttttacgagc tgagacctca gcgaagtaga agcagatgtt ccgcccatgc gacaaggtga
    13741 gaccgaaggt cgagaaggtg ccctggggta taggactcgt agaatgagga ggtacaccga
    13801 cgagatgata cggtaagtcc gaaccgctta gtgtgagttt attggtaaaa cgcagctaaa
    13861 cgtctcgaat atttcattca cggtgagatg ctgtagctaa gaatgagcta attgaggat
//
