GCA_002834165.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaLKNPHNPM_18 (original name was: gnl|Prokka|LKNPHNPM_18)

Region	Type	From	To	Most similar known cluster		Similarity
Region 18.1	ranthipeptide	129,694	151,301
Region 18.2	RRE-containing	252,220	272,483

gnlProkkaLKNPHNPM_25 (original name was: gnl|Prokka|LKNPHNPM_25)

Region	Type	From	To	Most similar known cluster		Similarity
Region 25.1	NRPS,HR-T2PKS	72,364	160,257	leucomycin	Polyketide	3%

Region	Type	From	To	Most similar known cluster	Similarity
Region 18.1	ranthipeptide	129,694	151,301
Region 18.2	RRE-containing	252,220	272,483
Region 25.1	NRPS,HR-T2PKS	72,364	160,257	leucomycin	Polyketide	3%

No secondary metabolite regions were found in these records:: gnlProkkaLKNPHNPM_1 (original name was: gnl|Prokka|LKNPHNPM_1); gnlProkkaLKNPHNPM_2 (original name was: gnl|Prokka|LKNPHNPM_2); gnlProkkaLKNPHNPM_3 (original name was: gnl|Prokka|LKNPHNPM_3); gnlProkkaLKNPHNPM_4 (original name was: gnl|Prokka|LKNPHNPM_4); gnlProkkaLKNPHNPM_5 (original name was: gnl|Prokka|LKNPHNPM_5); gnlProkkaLKNPHNPM_6 (original name was: gnl|Prokka|LKNPHNPM_6); gnlProkkaLKNPHNPM_7 (original name was: gnl|Prokka|LKNPHNPM_7); gnlProkkaLKNPHNPM_8 (original name was: gnl|Prokka|LKNPHNPM_8); gnlProkkaLKNPHNPM_9 (original name was: gnl|Prokka|LKNPHNPM_9); gnlProkkaLKNPHNPM_10 (original name was: gnl|Prokka|LKNPHNPM_10); gnlProkkaLKNPHNPM_11 (original name was: gnl|Prokka|LKNPHNPM_11); gnlProkkaLKNPHNPM_12 (original name was: gnl|Prokka|LKNPHNPM_12); gnlProkkaLKNPHNPM_13 (original name was: gnl|Prokka|LKNPHNPM_13); gnlProkkaLKNPHNPM_14 (original name was: gnl|Prokka|LKNPHNPM_14); gnlProkkaLKNPHNPM_15 (original name was: gnl|Prokka|LKNPHNPM_15); gnlProkkaLKNPHNPM_16 (original name was: gnl|Prokka|LKNPHNPM_16); gnlProkkaLKNPHNPM_17 (original name was: gnl|Prokka|LKNPHNPM_17); gnlProkkaLKNPHNPM_19 (original name was: gnl|Prokka|LKNPHNPM_19); gnlProkkaLKNPHNPM_20 (original name was: gnl|Prokka|LKNPHNPM_20); gnlProkkaLKNPHNPM_21 (original name was: gnl|Prokka|LKNPHNPM_21); gnlProkkaLKNPHNPM_22 (original name was: gnl|Prokka|LKNPHNPM_22); gnlProkkaLKNPHNPM_23 (original name was: gnl|Prokka|LKNPHNPM_23); gnlProkkaLKNPHNPM_24 (original name was: gnl|Prokka|LKNPHNPM_24); gnlProkkaLKNPHNPM_26 (original name was: gnl|Prokka|LKNPHNPM_26); gnlProkkaLKNPHNPM_27 (original name was: gnl|Prokka|LKNPHNPM_27); gnlProkkaLKNPHNPM_28 (original name was: gnl|Prokka|LKNPHNPM_28)

Compact view

gnlProkkaLKNPHNPM_18 - Region 1 - ranthipeptide

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Location: 129,694 - 151,301 nt. (total: 21,608 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaLKNPHNPM_18 - Region 2 - RRE-containing

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Location: 252,220 - 272,483 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaLKNPHNPM_25 - Region 1 - HR-T2PKS,NRPS

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Location: 72,364 - 160,257 nt. (total: 87,894 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

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transport-related genes

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resistance

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

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Similar known gene clusters from MIBiG 3.1

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 72363 - 160257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 72363 - 119695:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg25_83

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AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)