LOCUS       c00025_gnlPro..        15494 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LKNPHNPM_25.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 22:30:05
            Original ID  :: gnl|Prokka|LKNPHNPM_25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15494
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15494
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2266:5494]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2267..5494
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15494
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15494
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             127..1965
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGTTVKYVAAPEISKLESVNGGVKISWGKVSGATKYRV
                     YYKGSKGWTKMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVA
                     TPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFD
                     LSIDDIYYTVRCISKDAKSFTSGYDSKGTPIGNHQDCPEIYSIGAVNNGVEMHWTGDAP
                     KFRVYIKENGSWKRIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYR
                     YKTSDKTRDAYINYMMNHTDEWMPSLGSNHNLSGVMFLDFDFDGVPELVAQKADSNEYS
                     FHSVVYKFEDGKLKRVGNVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITY
                     DGETLFANMYSARGVGEESNNNIYYSYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTQ
                     FIATGYGDNSVWGENTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(2267..3307)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_2"
                     /sec_met_domain="IlvN (E-value: 5.2e-83, bitscore: 269.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 7.3e-60, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLR
                     DSGCDVIVGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(3368..3859)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.1e-29, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(3872..5494)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(5692..6936)
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="LKKIFLLLVTALFLLSLYGCNTSSSSNNPTEQTTVTDTDDLSLDS
                     DTDSETEFNYDLEIYYNDKKIDNLNLFDALMPTEDGLIYSKINETSPNEIEYYRYYLDK
                     KNSVKLGSIKNWSMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMTTVF
                     SDKGGFPYDTITGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIR
                     KVSIDKSTKTISLLVLDCISQNEASLKIETYDYDMNFLKSYDISNISDDSNELIQGVQV
                     FDFKNNYLFYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRA
                     ESSSENNYIYLFDTTNKTMKETKFNIEEKGYTIGGISRIGKDNLMIMMSPDNTDEKSNL
                     NPRIYFTKLSDLNFQ"
     CDS             complement(7136..9460)
                     /locus_tag="ctg25_6"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETDD
                     FEDVSFNFATKLLNFKSEKQNPVSEIQSICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KINHDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMAVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQVVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVENTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVIIAARLLKKKY"
     CDS             complement(9473..9790)
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             10520..11812
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDSLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             11935..12723
                     /locus_tag="ctg25_9"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             12745..13230
                     /locus_tag="ctg25_10"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKPMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             13245..14984
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MALDGIFLRHIKSEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLKCSVLDVCTAVKNLDTEMPLNKALLRTIEGVSPIVCREIEYKVMEGATN
                     RIEGVLFDRLAVEIEKLKSVCSDCSGKPVVVYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYIDSVLDTVDRAENEKDLAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKEISD
                     TAIYEAARLAAYHSKARNSSQVPVDYTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQTV
                     EKQ"
ORIGIN
        1 aaaaatttgt gatagtttat caagatgtat tgctttttat atcatttaat gttacaatta
       61 acttgcataa aaatttagcg aaagttttta ataatgcata gaatttgaac aaagcgaggg
      121 atagatatga aaaagttttt acctatagct atggcggcgg taatgtcgat gtctgcggtt
      181 gcggtttcgg cagtttctgc aaatgcggtt gaaccgctta acacacccgt gcagtatgca
      241 caggttgcaa gggcaagctt ggcaactccg aaaatttcaa aagccgaaag cgtttacggt
      301 ggtgtaaagc ttacatggaa caaagtgaat ggtgcggcta aatacagagt ttactacaag
      361 ggccgtaaag gttggacacg aatggtcgat acaacttcaa cctcatatat cgacaaggat
      421 gtttcatcgg gcaggaatta cacctatact gtaagatgta tttctgctga cggaaagagc
      481 tttacaagcg gttatgattc aaaggggaca accgtaaaat atgttgctgc tcccgaaatt
      541 tcaaagcttg aaagcgtaaa cggcggtgtg aaaatctctt ggggcaaagt aagcggtgcg
      601 actaaataca gagtttacta caaaggtagt aagggttgga caaaaatggt tgatacaact
      661 tcaacctcat atatcgacaa ggatgtttca tccggcagaa attacaccta tacggttaga
      721 tgcattacat cagacgcaaa gaaatttaca agcggttata acccgacagg caagtcggta
      781 aagtatgttg ccacaccgaa aatttcaaaa cttgaggtta catatgacgg tgtaaagctg
      841 acatggaaca aggttgcagg tgcagagaag tatcgtgtgt actacaagga cagaaacggt
      901 tggacaaagc ttgccgatac aacaggcacg actatgcttg atatgaatgt tgtttcaaag
      961 gaatttgatt taagcattga tgatatttat tacacggttc gttgtatcag caaggatgcc
     1021 aagagtttta caagcggcta cgattcaaag ggtacgccta ttggcaatca tcaggattgt
     1081 cccgaaattt acagcattgg tgcagtaaac aacggtgttg aaatgcattg gacgggagat
     1141 gcgccaaagt tccgtgttta tattaaagaa aacggttctt ggaagaggat agcagaaact
     1201 tatgacaact attatgttca caagggtgca aagtccggca gtaacactta cacagtaaga
     1261 ggtgtttcaa aagacggtaa aaagtttact acgatgttta acccaaccgg tgtaacatac
     1321 agatataaga catccgataa aacaagggac gcttatatca actatatgat gaatcatacc
     1381 gatgaatgga tgccaagctt gggaagtaat cacaatttgt caggtgttat gtttttggat
     1441 ttcgactttg acggagttcc ggagcttgtt gcacaaaagg ctgattccaa tgagtatagt
     1501 ttccattccg ttgtttacaa atttgaagac ggtaagttaa aaagagtggg aaatgttaac
     1561 gacggttttg cgatatacta taataaaact gccaaaaagt atgaggttca cgacctaaag
     1621 atatctttaa atgtagatga cggttactat tggtcgggta attcaataat cacatacgac
     1681 ggagagactc tttttgcaaa tatgtattcg gcaagaggcg taggcgaaga atcaaataat
     1741 aatatttatt atagttattt tgacggtaat gacaaaaata tttcacgggc aaaatataac
     1801 gaaattaacc ttaaacagtt taataattgc gtaaatgcac atatgtttac ccaatttatt
     1861 gcgacaggtt atggtgataa cagcgtatgg ggtgagaaca ctaccgctga gaataagcag
     1921 tctttgcttg acgcttataa ttctttctcc tatgagaagt attgattatt taaaaattaa
     1981 taagttttaa ctgcaaaagg gttcagccgt aaaaagctga acccttttat tgcacaacaa
     2041 aaaacggttc agccaaattg actgaaccgt taatctgtac tatgttaagc ttgggaataa
     2101 gtagttgtaa attatcacaa actacctaca cgaactacga gcgaggtact cgcaaaaagg
     2161 gtagcttgaa aatcaagcta ccctaaattc gtactatgta atgctcgggt gacagaagtt
     2221 tgaatacatc aaactgtctt cacgaactgt gtgcgagaca ctcgcattag ttgttgatga
     2281 gcttatcttc gtcagaccag ctatagagct ttctaacttc cttaccgaat acttcggcag
     2341 gagcttcggc agcgagcttt ctcatagcct tgaagtgaac ctgtgaaccg gcatcgctca
     2401 tgtcaaggag gaagtcctta gcaaatgtac cgtcctgaat gtcagaaaga acctttctca
     2461 tagccttctt agtatcctct gtgatgatct ttggacctgt gatgtagtca ccgtactcag
     2521 ctgtgttaga gattgaatat ctcatgcctg caaaacctga ctgatagata aggtcaacga
     2581 tgagcttcat ctcatggata cactcaaagt aagcatttct tgggtcgtaa ccggcatcgc
     2641 aaagtgtttc aaaacctgcc tgcataagtg cacaaacacc gccgcaaaga acagcctgtt
     2701 caccgaagag gtctgtttct gtttctgttc tgaatgttgt ttcaagaacg ccggctcttg
     2761 caccgccgat accgagtgca tatgcaagtg cgagatcctt agcctgacct gtagcatcct
     2821 gttcaacagc aacgaggcaa ggtacaccct taccaacctg atactctgaa cgaactgtgt
     2881 ggccaggtcc cttaggagct accattgtaa catcaacatc ctttggaggc ttgatgcaac
     2941 cgaagtgaat gttaaagccg tgagcgaaca taagcatatt gcctgcttcg aggtttggct
     3001 cgatgtcgtt cttgtaaaga gctgcctgct tttcatcgtt gataagaatc atgatgatgt
     3061 cagcctgctt tgcagcctct gctgatgtat ataccttaaa gccctgtgcc tcagcctttg
     3121 cccagctctt gctgcctttg taaagaccga cgattacatc acaacctgaa tccctgaggt
     3181 tgagagcgtg tgcatgaccc tggctgccgt aaccgataat agcaattttc ttacccttga
     3241 gaaggtcaag gttgcaatct gactgatagt agattggtgc tgtcatgttt tttgtgtagt
     3301 ctttcatatt aaagtcctcc ttaccgcaaa cgcggcatat aaattaaaat atatgctaac
     3361 tgtaagatta aacggaaacc gaagctgtgc ctctgtcgat ggcaacagta cctgttctta
     3421 caatctcacg gataccataa ggcttgagta agtcaacaag cgtgttgatg cggcttgcac
     3481 attcgcagta ctcaacggta actgacgaag gggatacatc aacgattttc gcctgcataa
     3541 tttcaaccgt tttgacaatt tcggctcttt ttgaggcggc gcaatgaacc ttgattaaaa
     3601 caagctcacg gctgataaat tcgccctcgt taagcctttt taccttaata acgggaatga
     3661 gcttgttgag ctgtttttca agctgttcaa caatgtactc gtcaccgttt gcaacgattg
     3721 tgattcggga aaccgacggg tcctgagtaa cacctactgc aagtgagtcg atgttaaaac
     3781 ctcggcgaga gaaaagtccc gaaatctttg aaagaacgcc cgcctgattt tcaacaagta
     3841 ttgataatgt atactgcatt ttatcacctc attaaattga cggagtgtcg gggtgaacat
     3901 cgcaaacaag aatgaacggt ttttccgaat caacaatacc cttgatgatg ttttcggctt
     3961 ccttgtttga atgagcctct gcatggtcaa tgccgtaagc atcggcaatc ttcaagaagt
     4021 cgggatcacc gttgagaatt gttgcggagt gtctgccgcc gtagtgtttg tcctgaagtt
     4081 cacgaaccat tccgagtcgt gcgtttttca taatgatgat tttaattccg agctgattgc
     4141 ctgcaatagt cgcaagctca ttaagcccca tctgaaaact gccgtcaccg cagattacaa
     4201 taacatcacg gtcgggtctt gcaaactttg caccgattgc agcgggaatt gagtaaccca
     4261 ttgtacccat accgcctgtt gtgaggaatc tgccctcacg aatacggaag ttgtttgcac
     4321 accagatttg attttgtcct acatcggcaa caagaattgc cttcgagcgg aacattgcac
     4381 tgagatgacc gacaagtgtt ctcggctcaa caaagccgtc aaaaacggga ggctcacggt
     4441 aaaggtcttt tttccagttc tttacggttt cgctccacat tgttgtaacc ttgtaatcgc
     4501 cgatgctgtc aagcagcata ttgatgacat ttttcatatc gcctacaatc ggaatttctg
     4561 ttttaacatt cttaccgatt tcagcagggt caatgtcaat gtgaattacc tttgtgtttt
     4621 cactcatctg gtcgggagcc gcaacagctc tgtcaccgag tcttgcaccg catacgatta
     4681 caaggtcggc ttcgtgaaga gcacggttgg caacagcctt gccgtgagtg ccgagcattc
     4741 cgagataaag ctcatgctcg ctgggcataa caccgatgcc catcatagtt gaaataacgg
     4801 ggatacccgt agtttctgca aatttttgaa gcttaagctt gatacccgaa ctcagcacgc
     4861 cgccgcctga tacgataaca ggacgcttgc ttgcgttgat ggcctcaaca gcctttttaa
     4921 cctgaattgc gtgtccctta gtattcggct tgtaaccgat aatgtttacg ctttcgggat
     4981 attcaaaact ttcaatttca ttttcctgaa tatcaacggg aatgtcgata agtacaggac
     5041 cgggtctgcc ggttgaggca atatggaaag cctctttgaa aactctcgga aggtcttctg
     5101 ttttgctgac gagataactg tgctttacaa acggttcaca agctcccgtg atgtcagctt
     5161 cctgaaagac atctctgccg agaaggtcgg aacgaacctg acctgtaatg gcaacaatcg
     5221 gaatagagtc cgtataggcg gttgcaatgc ctgtgatgag gttggttgca ccgggaccgg
     5281 aagttgccac gcaaacaccg ggacgattac tgcatcttgc atagccgctt gccgcatgag
     5341 cagcgttctg ttcctgacga acaagaatgt gggtaatgct cgaatcgtaa actttatcgt
     5401 aaaatgggca gatagccgca ccgggataac caaagactat gtcaacgccc tcggcttcca
     5461 aacattttac cataatttca gcaccgctga tcattatgtt ttgtccctcc tatccttatt
     5521 tattgtgagc aaaaggtgtt ttgtaacaat aaatatacct ttttgcttta ccgctaatta
     5581 tacaataaat accttaaaaa gtaaagagca gtattgccca taaattaaat tttttgcagg
     5641 attttgacag ataatttgca aaatggattt taattgattt ttaccgcctg tttactgaaa
     5701 atttaagtcg cttagttttg taaagtatat tcttggatta aggttgcttt tttcatctgt
     5761 attatcaggg gacatcatta tcatcaaatt atcttttcct atccgtgata taccgcctat
     5821 agtgtaccct ttttcttcaa tattaaattt tgtttctttc attgttttgt tggttgtatc
     5881 aaaaagatat atgtagttat tttctgaact tgattccgcc ctcttataca ataaatttgt
     5941 atcactgtca tcttcagatg cggatactat tgaaaaagta tcatctacat cttctgatat
     6001 gtcggatttt ttcagcttat cgctgtctat atatcctata catcttgtta tgctgaaatt
     6061 ttgatagaat agataattgt ttttaaaatc aaaaacctgt acgccctgaa ttaattcgtt
     6121 tgaatcatct gaaatgttgg atatatcata gcttttgaga aaattcatat catagtcata
     6181 agtttctatt tttaaagaag cttcgttctg tgaaatgcaa tccaaaacca aaagagagat
     6241 tgtttttgta cttttgtcaa ttgaaacttt tcttatagtt tccccgatac tgtttttatc
     6301 atcaaactct aaatatttca gttgtttaaa cttttgcgtt tcggtgtcat acagttccaa
     6361 agaagtaccg ttgtttaata cttttgtaat tatgacaaga ttgtctgcac ctgtaatggt
     6421 atcataggga aaaccgcctt tgtcagaaaa gacagtagtc attttgtttt tattaaggtc
     6481 tatatcaata aattcaaggg ttctgttttc ttcgtctgta atgtcacccg tgcttgccat
     6541 aaaacataag tgattattta catacgcttt atcgttaatt tgcatagacc agttttttat
     6601 tgaaccaagt tttacactgt tttttttatc taaataatat ctgtagtatt ctatttcatt
     6661 cggagaagtt tcgttgattt ttgaatatat gagtccatcc tcagttggca taagtgcatc
     6721 gaaaagattt aaattatcaa tctttttatc gttatagtaa atctccaaat cgtaattaaa
     6781 ttctgtttca gaatctgtat ctgaatcaag agataaatca tctgtatccg ttacggttgt
     6841 ttgttcagtg gggttattgc ttgatgaaga agtgttacat ccatataatg aaagtaaaaa
     6901 taaagcggtt actaataata aaaatatctt tttcaaatta atctctccga agtttattta
     6961 tcagttacaa gcactgacaa aaacattata atttatataa ttataaaagt caatgatttt
     7021 aaaatactat aatataagat tatgtttaga aaaattttgg caaatgaaag caccgtgaaa
     7081 cttgtgaaag ctcacggtgc tttatcataa taaatgatat gatttgcaaa aaaaatcaat
     7141 atttcttttt gaggagtctt gcggctatga tgacgcagac tacgctgacg cctgtgtcgg
     7201 cgataacgga catccagatt tgtgcaagac cgaatgcggc gaggataatt acaagagcct
     7261 tgattgagag ggcaaagatg atgttgcctt tgacggtgtt gataacactt cttgcaattt
     7321 taattgcctt tggaagctgt ttgagtgtgc ctgatgcgag aactgcgtct gacgcttcaa
     7381 tagcggcttc actgccgaat cccattgcga taccgcagtc gcttgccgaa agaacagggg
     7441 catcattgat gccgtcgcct acaaagcaag cacccttgga ttttgatttc aagcccttga
     7501 aaagctcaag cttttgagca gggagaagtt ctgcgtgaca ttcggaaagt ccgagttcgt
     7561 ttttaacatt ttcggcaggc tgttgtctgt cgcctgtgag cattaccgtg ttctcgacac
     7621 cgagcgcttt aagctgtgag ataacctctt ttgcctcagg tcttactgtg tcgctgacat
     7681 tgagcgaacc gataagctga ccgtcataaa ttacgaaaac agaatcgtct ttatttgcaa
     7741 tcttcttctg ttcgtccgaa agaatctttg aaccgccgca ctgaatagtt ttgccgttat
     7801 aaactgcgct tgttccgtga ccggcacttt cgctgtagtc ggaaagctcg ggaagttcaa
     7861 gaccgtttgc cttttctctg attgcggatg caatcggatg agcggaatat ttttcgcttg
     7921 cagcggcaag agcaagaact tcgtcagcac tgtatgaacc gacagtatta accttgttta
     7981 cgctgagctt gccgcttgtg agcgtgcctg ttttatcgaa tacgaatgtg tctgctttcg
     8041 caagagcctc aatatatttt ccacccttga tgagtacacc gacttcggat gccgcaccga
     8101 tacccgaata gtaggagaga ggtacggaaa taacaatagc acacggacat gacgctacaa
     8161 gacaaacaag cgcacggtat agccattcgc tgaatgctcc gagtccgcaa agcggaggaa
     8221 ttactgcgat tgcaactgca atgagtacaa caaccggtgt gtaaacagag gcaaatcttg
     8281 aaataagctt ttcgctgttg cccttttgag cggcggcatc ttcaacaagc tgaagaattc
     8341 ttgttgcggt actgtcgccg aaatgctttg tggttttgac agtaataagg ttactgccgt
     8401 tgattgcgcc gctgagtacc tcactgccct cgcctgcatc aacaggaagg ctttcgcctg
     8461 tgagagccga tgtgtcgaga gtcgttttac ctttgataat aatgccgtca agcggaactc
     8521 tttcgtatgg cttgacttca atgatacttc cgatttcaac gctttcggca ggaacaacct
     8581 gttctgcacc gtcaacaata attgttgctg tatcgggacg aatgtttgca agcttttcaa
     8641 tgtcacggcg ggatgcgtca actgctcgat cctcaaaaat ttcaccgata gaaaagagga
     8701 ttgttaccat tgccgcctca acaaaatctc caagacagaa tgccgcaatt accgcaacag
     8761 ccataagcgt tgtttcgtca attctcagct ttagaatgtt ttttgcaccc ttgataaata
     8821 ccttgtaacc cgaaagaagt gttgcaacaa aacacgctgc gagtacaaca taatgaacag
     8881 ccgtaacacc gtcaagtgta aggtggagaa tttcggacac tacagcaagt acaattgaaa
     8941 ttgcaaggaa gattgtgtca tggttgattt tctttttcgt gatttcgggt tctgcctttg
     9001 ttgtgatatc atttttcgga gttttgtcaa caacagttac accgtcctca atgctgtcgc
     9061 agatcgactg aatttcggaa acaggattct gcttttcgct tttgaagttg agaagttttg
     9121 tcgcaaaatt aaagcttaca tcctcaaagt cgtctgtttc tgcaatttta gcctcaattt
     9181 tgcccgcaca atgagcacaa ttgagattgt ctaaagtgta ggtgtatttt ttgagattgg
     9241 ttttcggagt tttgtcaaca acggttacac cgtcctcaat gctgtcgcaa attgcctgaa
     9301 tttcggaaac aggattctgc ttttcgcttt tgaagttgag aagttttgtc gcaaaattaa
     9361 agctcacatc ttcaaagccg tttgtttctg caattttagc ctcaatcttg cctgcacaat
     9421 gagcgcagtt gagattatca agctgatatt tgtacctcat atgtctccct ccttattcaa
     9481 ggacatggtc aagtcccatt tcgatgattc gtttcacatg gtcatcgtca aggctgtaat
     9541 aaatctgctt tccttcacgg cgaacacgca ccagcttgtt ctgccttaac acacgcagtt
     9601 ggtgggaaat tgtgctttgc tccatgctga gagcttcagc aatgttgagc accgacattt
     9661 cattttccga aatggtgtac ataatgcgaa gtcgggttga atcaccgaaa accttaaaaa
     9721 ggtctgcaag ctcaaacagc acatcaatgt cgggcatttc gggagtggtt gttttttctt
     9781 tgttttccat aggcgtcccc ttaattttct ctcaggttaa tagttatact tgaacatatg
     9841 aagatatgct catatgttaa ttataatata gcattccctt tttaaaaagt caatagacac
     9901 acacgaaaaa atgtaatgtt tttcaagttt ttttgcccca aagtttcacc tgtttattgt
     9961 gtccgtttgg aaagtatata tagtatagaa agttaatttt aaatttgaaa aaagaagatt
    10021 gaaggtgtaa aattatcata ggaataacgg aacgatattt ttctgtgttc aatttgaatt
    10081 ggaaaatact cagatgtttg atgataacac gaaaataaca cttgtttcaa tttgtaataa
    10141 ttttacaaaa aattgcttta attaattact tctttttagg aaaaaacggt tttaaaaagc
    10201 atggttggtt atattaaaaa caaaaaaagc aacaaattaa taatttgagt acaacttgcc
    10261 caaaaataga ttacagtttt attattccgt tgactttaat acaattttgt agtatcattt
    10321 tctgtaagag atttgttaaa ttacatctgc gtaaccgagt gggttcgttt ttaataaaat
    10381 gtaacaaatt agttctcatt atgaatttta gattcgtata atttttgatt tttacttata
    10441 cactatatag atatacattt tcagatattt agcttattta gttaaaagta tcttctacac
    10501 attaattggg gtgtaacaat tggagaagtt cgtagttacc ggcggaaagc cattatcggg
    10561 tgaagtgaca atcagcggtg cgaaaaatgc agccgttgca attattccgg cagttattct
    10621 ttgtgatgaa ccgtgccaga ttgaaaatat tcctaacatc agcgatgtat cacttatcag
    10681 cagaattctt cagcagatgg gtgctaatgt aagacgaatc aaccgttcgt ccttatatat
    10741 tgatcctaca aaaatccgca catgcaatgc tgtgaccgac cttgtaagag gtatgagagc
    10801 gtcatattat ctcctcggcg cacttttggg caagtacggc aaggctaagg tggctcttcc
    10861 gggcggctgt aactttggcg tgcgtccgat tgaccagcat cttaaaggct ttgaggctct
    10921 cggtgcgaca actcagcttg ttgacggtgc gattatagag gcagaatgcg acagccttgt
    10981 cggtacacat gtgtaccttg atgttgtgtc cgttggtgca acaatgaaca ttatgcttgc
    11041 cgcatcaaag gcaaagggac agaccattat tgaaaatgcc gcaagagaac cgcatattgt
    11101 tgaccttgcg aacttcctta attcaatggg tgcggatgtc aggggcgcag gtacggatgt
    11161 tatcaaaatc cgtggcgttg agtatcttca cggcattact tattcgatta ttcccgacca
    11221 gattgaggca ggaacatata tgtgtgccgc cgccgcaaca agaggttgta ttacggtaaa
    11281 gaatattaca ccgaagcatc ttgaatcaat cagcgcaaag ctgcgtgaga tgggtgttaa
    11341 gattacggaa tatgatgaag ctctcaaggt tgatgcgtca tctgctccgc taaagcgctg
    11401 taatatcaag acaatgccgc atcccggctt cccgacagac tgtcagccgc agtttgccgc
    11461 attgcttatg agcgttcccg gaacaagcat catcaacgag aatgtttggg ataatcgcta
    11521 ccagtatgtc agcgagctta tcagaatggg tgcgcagatt tctgttgagg gcagacttgc
    11581 aatcattgag ggcggtgttc cgctcacagc ggctcccgtt aaggcaaccg accttcgtgc
    11641 aggtgcggct atgattattg ccgctcttga aattaacggt acaacagaga tttcaaatat
    11701 tcagttcatt gagcgtggat atgaagatgt tgttgaaaag ttcagaggac ttggtgcaga
    11761 tatcaaaaag gtgtatttta caggagacaa cgagcaagag ctcggtgcct gactaaaatt
    11821 taattagaaa tcaaagccgt tttctttgtg agaacggctt ttttgtgaga taatttacaa
    11881 attttaaaat ttgtgttatc atattcgtta tactaaagat aaggattgat tgttttggca
    11941 agagcagtac cgctgttcag cggaagtaag ggtaacagct actacatagg ttcggcaagc
    12001 gaaggcgtac tgattgacgc aggtcgttca tgcaagcaga ttgaaaatgc catgcttgca
    12061 aacggacttg atatgggcag tatcggggcg gtttttataa ctcacgaaca cactgaccat
    12121 tgcagtgcct tgcgtgtgct tgcaaagcgt tacggcttta aggtatattc aagtcttggt
    12181 acgctcaatg ctttgagggc aggtaataag cttgatccaa acacggatgc agatgttata
    12241 actgacgagg ttgtaatcgg caatatgcgt gttcagcgaa ttgacacccc ccacgatgcg
    12301 gcggaaagct gttgttaccg tgttactgct cccgacggaa aatccgcact tatagcaacc
    12361 gatatgggcg ttatgttgcc cgatgtcaga actgccgcag agcagagcga ctttgttgtg
    12421 cttgagtcaa atcacgatat taatatgctc aaaaacggat tttatcctta tccgctaaag
    12481 cagagaatcc tttcaaacag aggacatctt tcaaatgagg catgtgcaaa agaacttgtt
    12541 aaccttgttg aaaagggaac tttaagactt atgctcggcc atctcagcga agaaaataat
    12601 accgttccgc ttgcaatgtc gacatccgta gacctgctca catcaaacgg aatgaagtac
    12661 aaaagcgatt attcgcttga tgttgctccg agtgtaagca caacaaaagc catcatcttt
    12721 taaccttaaa caaacaagag aaatatgatt aagattaaca taatttgtat cggcaaaatc
    12781 aaagaaaaat attttaccga cgcaattgca gagtatgcaa aacgcttgac cgcattttgt
    12841 aaattcaata ttattgagct ttcggaagaa cgcattaaga gcaacatacc gaataggtcg
    12901 cagattgatg aggttatttt ctctgaggga aaacgaatca tgcagaaaat ttcgccttcg
    12961 gattatgttg ttgcaatgtg tattgaggga aagcctatgt cgagcgagga gctttcaaag
    13021 ctgattgaca atgcgtccgt aagcggaaaa agcaccgttg attttattat cggcggcagc
    13081 tacgggcttg acgaatcggt taaaaaacgg gcggatgtcc gtctttcaat gagcagaatg
    13141 accttccctc accaaatggc aagaatgatt ttaagcgaac agatttaccg tgcgtttgaa
    13201 atttcatcaa acggtaaata tcacaaataa tttacggagt tactatggcg cttgacggaa
    13261 tttttttaag acatattaaa agtgaaatag aaaaagaggc tctcggtgca agggtgtcgc
    13321 agatttatca gccgaacaga gaggagcttg tgttcgggct gagaacattt tccggcaaca
    13381 aaaagctgtt gctttctgca cgagcaaatt caccgagagt gaacttctgt tcgtcaacac
    13441 ccgaaaatcc tgcacaacct ccgatgttct gtatgctttt gcgaaaaaga atcggcggcg
    13501 gaaagcttgt gggacttcgc cagaacggtt gcgaccgtgt tcttatgctc gatttcgagt
    13561 gcgtgaacga actcggtgat actgtgatga taactgttgt atgcgaaatt atgggtatgt
    13621 acagcaacat aattattgtt gattcaaacg gcgtcatcat tgattcactc aagcgtgtag
    13681 atcttacaat gagcagtaaa agacttgtac tgccgaatat aaaatacgaa cttcccgaat
    13741 cgcagaacaa gctgaatctg cttaaatgtt cggtgcttga tgtgtgtaca gccgtaaaaa
    13801 atcttgacac ggaaatgccg cttaacaagg cgctgttaag gacaattgag ggcgtttctc
    13861 cgattgtatg ccgtgagatt gaatacaagg ttatggaggg cgcaacaaac agaattgagg
    13921 gtgtgctttt tgaccgactc gcagttgaaa ttgaaaagct gaaaagcgtt tgcagcgatt
    13981 gttcgggcaa gcctgttgtg gtttatcgtg aggacggcaa gcctatggac ttctgcttta
    14041 tgaatgttga gcagtacggc gattttgcaa aggttgagag taaggaaagc ttctccgatt
    14101 tgcttgacgg attctatgag gctcgtgaca gtcgtgacag aatgagggtg aaatcacaaa
    14161 gccttacaaa gcttttgaac aacacacttg aaagacttgc acgaaaaatt gcaaagcaga
    14221 agagtgagct tgaacgctgt gcagaccgtg agcatcttcg catatgcggt gaccttttac
    14281 aggcaaatat ctatcgcatt gagcgtggtg cggagtatgt tgatgttgaa aacttttacg
    14341 atgagaacaa cgcaatttta cgcataaagc ttaatccggc aatctcacct tcggcaaatg
    14401 cccagaagta ttacaaggat taccgcaagg ctaaaaatgc cgaaattatg ctcaaagaac
    14461 agcttgaaaa gggcagagaa gagcttgatt atatagactc cgttctcgat acggttgacc
    14521 gtgcggagaa tgaaaaagac cttgcgcaaa ttcgtgagga acttaccgag cagggctatc
    14581 tcaaggttca aaagggcaaa aagccccgtc agacaacttt gccgccgctc gaatttgaat
    14641 caagcgacgg ttttaaaatc cttgtaggaa gaaacaaccg ccagaacgat aagctgactt
    14701 tgaaaacagc atcaaagaac gatatgtggt tgcatacaaa ggacattcac ggttctcatg
    14761 taattgttgt ttcggacggc aaagagattt ccgacacggc aatctacgag gcggcacggc
    14821 ttgcggcata tcacagtaag gcgagaaaca gcagtcaggt tcccgttgac tacacacttg
    14881 ttcgctatgt gtcaaagcca aacggctcaa aaccgggtat ggtgatttat gtcaacaaca
    14941 aaaccctgta tgtaaaaccg tcacaaacgg ttgaaaagca gtaagatatt ttaataaaaa
    15001 ttaaacggag ggcaagacgc tctccgtttt tatgttaatt taattgtttt taacgggcgg
    15061 taaaatcgaa tgtaaaaatt cgtattttag gggtgcagaa tttgaactca tacccttcag
    15121 aatttgcacc tgcccccttc agaatttgaa cccgccccct tcagattttg aaggggacta
    15181 cttcagaatt tgaagcctaa taatacccat agaaaaagac taagagaata ataccaagta
    15241 aacaatacca attgaaaaat gaagaggaat tcagatgacc gaactgacaa aatcatcctt
    15301 caaaatccca ttcggggaca tagctttcat ctgcggaaga aagctcctgt gtaaagccgt
    15361 caattcccag tcgcatcatt tcaagcttta ccttgtcata ttctctgcgt gtgattttac
    15421 ggttaattcg tgaaaactcc ctgtcgctga ccttgcccat aggaatgtac tgacacataa
    15481 gacttaacaa aacc
//
