LOCUS       gnlProkkaLKMAKOFG_32    9161 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LKMAKOFG_32.
ACCESSION   gnlProkkaLKMAKOFG_32
VERSION     gnlProkkaLKMAKOFG_32
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:51:10
            Original ID  :: gnl|Prokka|LKMAKOFG_32
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9161
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1347)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     372.7; E-value: 6.3e-113)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_1"
                     /sec_met_domain="DUF4135 (E-value: 3.3e-77, bitscore:
                     249.5, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAGDVHNGGKSVVIIEFENNKLVYKPRSLEIDVFYEKVIDYVNQ
                     YYQTNLKTPLSLDQGEYGWQEYVQAEPCDNIEQVRNYYYQFGMHLGFIYAFQGSDFHFE
                     NIIASRDKPVLVDLETLFQSSLFFSEENKENVNLMASAQVNKTILKSALFNYMSFPEDN
                     GLTNIGGLINTENQKGEKEEVLHIKTDKISMRKKQYLFKRGRNLPVYKNKVAECFEFER
                     EFIEGFKRIYFILKEDLYIRNLISDLNYAPIRIIVRPTYVYASFLETLLHPMYLKDYGE
                     RIRVLSFIKDAYTKYEVFDSISPFEIKDMMIGDIPYFNAPISEKRVYSNSIHVVDTGIM
                     KQSAKQEVLTRLANMSEEDMHQQVSLINMALSSTAANLDIIYKNQIDDFVPGYLKNDIQ
                     IKELIQIETDCILKQAIESEKYLQWVSIVSAPNGTLSVGPLSFGLYDGLA"
     protocluster    1..9161
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4668:7851]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4669..7851
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..9161
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9161
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(1527..1847)
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="MKKTQNSDNYVYENSMLNLFKEEDYFEGFAQYYISIFKAQIVKEI
                     DRIPSESLLDKGCLVESILINYKKKIYHLAGKTLIHEFHQTFDEFDQKNESKNYDIYSQ
                     KG"
     CDS             complement(1936..2112)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MKKDFQALTPMTEEELKKLAGGSDATPMTVTPTTITIPISLAGCP
                     TTKCASIVSPCND"
     CDS_motif       complement(2047..2112)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKDFQALTPMTEEELKKLAGG"
                     /locus_tag="ctg32_3_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(1936..2046)
                     /prepeptide="core"
                     /locus_tag="ctg32_3_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3391.9"
                     /monoisotopic_mass="3389.7"
                     /core_sequence="SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKDFQALTPMTEEELKKLAGG"
                     /leader_location="[2046:2112](-)"
                     /alternative_weights="3409.9"
                     /alternative_weights="3427.9"
                     /alternative_weights="3446.0"
                     /alternative_weights="3464.0"
                     /alternative_weights="3482.0"
                     /alternative_weights="3500.0"
                     /alternative_weights="3518.0"
                     /alternative_weights="3536.1"
                     /alternative_weights="3554.1"
     CDS             complement(2149..2325)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_4"
                     /transl_table=11
                     /translation="MKKEFLALEVMTEEELKELAGGSEATPMTVTPTTITIPISLAGCP
                     TTKCASIVSPCND"
     CDS_motif       complement(2260..2325)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKEFLALEVMTEEELKELAGG"
                     /locus_tag="ctg32_4_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2149..2259)
                     /prepeptide="core"
                     /locus_tag="ctg32_4_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3405.9"
                     /monoisotopic_mass="3403.7"
                     /core_sequence="SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKEFLALEVMTEEELKELAGG"
                     /leader_location="[2259:2325](-)"
                     /alternative_weights="3423.9"
                     /alternative_weights="3442.0"
                     /alternative_weights="3460.0"
                     /alternative_weights="3478.0"
                     /alternative_weights="3496.0"
                     /alternative_weights="3514.0"
                     /alternative_weights="3532.1"
                     /alternative_weights="3550.1"
                     /alternative_weights="3568.1"
     CDS             complement(2348..2506)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_5"
                     /transl_table=11
                     /translation="MKKNFSALYETSEQELKELVGGQNSVSITTYPITNHICPTITVGC
                     ACPQRQV"
     CDS_motif       complement(2441..2506)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKNFSALYETSEQELKELVGG"
                     /locus_tag="ctg32_5_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2348..2440)
                     /prepeptide="core"
                     /locus_tag="ctg32_5_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3119.6"
                     /monoisotopic_mass="3117.6"
                     /core_sequence="QNSVSITTYPITNHICPTITVGCACPQRQV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKNFSALYETSEQELKELVGG"
                     /leader_location="[2440:2506](-)"
                     /alternative_weights="3137.6"
                     /alternative_weights="3155.6"
                     /alternative_weights="3173.6"
                     /alternative_weights="3191.6"
     CDS             complement(2532..4679)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 222; E-value: 2.5e-67)"
                     /gene_kind="transport"
                     /locus_tag="ctg32_6"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.6e-29, bitscore:
                     90.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIRKRKLPVILQRNQFDCGITCLAMVLSRAEGIKINPNKLKLNK
                     EIIGRDGTDLIEMKKISETFDYDFKAFRTDNIMQLKELNKNHPLIVHWNHNHFVVVDAF
                     GTDNVKIIDPSSGRLTITLEEFKTFYNGISIMLIRKNELERKDKTASSLKDVSSFRKIG
                     KYLLKDKKLLGVIISFTFIFQALNLMTPFLTQYIIDSFIDGNEKILPIPMLFMLVIVSI
                     VLFFSLSLIRMKFIIKLQLKINKSMTEKIIHKIFSLPLKFFEANTAGDISTRIHNIAVI
                     REVISRLASTLILDISLIFVFFIVMFVYSPILSFIVLLGAAIQVMSTKILLPKIEMFTK
                     QEINSQSNFQSQLIEILRSMTFIKTIGETRNIESQLNYNFKHQLDYFSKRMNYSSLLGA
                     VSNAINLSLPLLILIAGTWSAASIGLTLGAVIAFSNIAGRFMSPLGSIIGSLESIKLVE
                     EMVDRVEAVLDEKDEEVNDKSSELFNPAAHNISLKNIDFSYNGNNYVLNNINLMIRPRE
                     KITLIGKTGCGKSTLIKIIAGLYQKTAGEICYGEFKIEDVNMVKLRETLGYIVQDVNLF
                     NDTIINNIKYFNEKITMEEVVQAAKEACIHEDIIKMPMGYHTMIGENGITLSGGQRQRI
                     SIARVLAKNPQILFIDEGTSNLDKDTELNILNNIYKKDITVISITHRTEWLEFSESVYE
                     IENGNLKTIKAKYESQLQQTY"
     CDS             complement(4669..7851)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     869.1; E-value: 7.3e-263)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_7"
                     /sec_met_domain="DUF4135 (E-value: 2.6e-102, bitscore:
                     332.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.1e-62, bitscore:
                     199.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLTNILLSKEKKAAVSQSDENENLFDRNLKLIYKNDIQMAQES
                     IHNVLSIQSIDKVKNLYQTPLHKSAFTVHVFENLKKGIAHQAIKKEDVNEEIMFHVFAL
                     KVSSYFNDLLKKSKFPSYDYLLEQPALFHHSISNQLEKIILKVSYRTLILDMNMNREKG
                     FLAGETPEEKYGYYNKTLLCSPEYLKSFFQQYPVLLRVIGNELRKFKKFILEFISRFEK
                     DKPELLSLFGFSEQVKIRDIEVGMGDSHSDGRKVTKITLNEGKLIYKPRSLEIDLLYKK
                     IIEFLNEKIRDHDIKLSTPNVLSRDGYGWTEFISFKACNCLKDIQNFYQRTGAQIGLLY
                     ALKAVDFHSENLIANGSYPVLIDLESLFHPAYQKKKDGMDAYEKAETQLHESVRALGLL
                     PFFFGGKADISGIGRKGKVKSVIKVPQLINLKTAEMSVKRDYVEIDTANNHPMLENKFV
                     YAKDYVEELKQGFSKAYMTILKHASELIRIIEKSENKIYVRFISKPTIKYSALLELSFH
                     PRFLHNSIDREIFLSKIWERPKQEDEYQSIVKYEFNDLINNDIPYFKVKLNEKDLLSSK
                     NKKIENYFPETPAQSVKERISNLSKDDLKFQLYVIELSMLASEDDRQIVLKEFITKEPG
                     QYVNVFSSNQESILIEKAEELAAYIYNQSYKAHTDKGSSYSWLNATPIGVDEIQWNLSV
                     MGDTFYDGLSGMAFTYLVLWRVTKKEKYLDIAEKIMKDVVSRFIDIEVKPDEDSSMSVG
                     AFSGVSSIVYTLMNFYMYTKREKYKQDAKQIAQLIPSLLPYDKELDIIGGTAGALIVMI
                     RSFEIENDTFFLSLAEQCGSFLMKQAIFLDEDFVTWEGIANKPLTGFSHGNAGMIYALQ
                     LLEKHSKHQDISMYIRKGLAFENSKKVNGNWLDLRKTVNEAATSAWCHGSPGILLSRLE
                     LKDSKHSDIAEVAKKDLNKTVSNIFYDGFGREQSLCHGDMGNALILIEYGKRTGESQFV
                     NIGKNLILESVQDKNIGFYQCGVGRDVETPNLMLGLAGIVYGMLYAADAELPNILNLEI
                     GRVDTLGDIYEN"
     CDS             complement(7938..8120)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="MNEKMYRFAGDLREELEEISLNEISGGGGAEQRGISQGNDGKLCT
                     LTWECGLCPTHTCWC"
     CDS_motif       complement(8040..8120)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNEKMYRFAGDLREELEEISLNEISGG"
                     /locus_tag="ctg32_8_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7938..8039)
                     /prepeptide="core"
                     /locus_tag="ctg32_8_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.40"
                     /molecular_weight="3435.8"
                     /monoisotopic_mass="3433.5"
                     /core_sequence="GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNEKMYRFAGDLREELEEISLNEISGG"
                     /leader_location="[8039:8120](-)"
     CDS             complement(8314..8979)
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 105.3; E-value:
                     4.2e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MIKILLIDDHIGVAQGTKAILEKSNKMGVTILSCCKEVLNHLKHY
                     EYDLLLLDLYMPELNGMELSKMILRESPDQKIIIYTGFDISVHFNLLVEVGVSGFISKS
                     STEEHMIKVIESVIEGDTIIPTHLFKQLRRTEANTFNIDKLEDRIRDITLNEREQDILA
                     GVAEGMTNRELSAKLLISQRAVEYILTGVYNKLGVKSRTEALIKANRYSLISMKTIYE"
     CDS             complement(8991..9161)
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="MDNGIGIDWNKVNSKTNSFGLTGIKERINCMNGIHNISSGVNEGL
                     LLRFEISTKNE"
ORIGIN
        1 agctaaccca tcgtacagcc caaaactcag cggtcctacg gataaggtgc cattgggagc
       61 cgagactatt gatacccatt gaagatattt ctccgattcg attgcttgtt ttaatataca
      121 atctgtttct atttgaatca gctctttgat ttgtatgtca ttttttaaat atccaggtac
      181 aaaatcatca atttgatttt tgtaaataat atccaaatta gccgccgtgg agcttaaggc
      241 catatttatc aagctcactt gctgatgcat gtcttcttcc gacatattcg ctaaacgagt
      301 taaaacttct tgtttagcgc tttgtttcat aatccctgta tccaccacat gtattgaatt
      361 tgaataaacc cttttttcac taataggagc attaaaatag ggtatatcac cgatcatcat
      421 atccttgatc tcaaatggac tgatggaatc aaatacttca tattttgtat aagcatcctt
      481 aataaaagat aaaaccctta tcctttctcc ataatctttt aaatacatag gatggaggag
      541 ggtttcaaga aatgaagcgt aaacatatgt aggtctgaca ataattctaa taggagcata
      601 atttaaatcg cttataaggt tccgtatata taaatcttct ttcaaaataa agtatattct
      661 tttgaaacct tcaataaatt ctctttcaaa ttcaaagcat tctgctactt tatttttgta
      721 aacaggaaga ttccttcccc ttttgaagag atattgtttc tttctcatag aaattttatc
      781 tgtttttata tgaagcactt cttctttttc acctttttga ttttctgtgt ttatcaagcc
      841 tcctatatta gtcagcccgt tatcttccgg aaaactcata tagttaaaaa gtgcagattt
      901 taatattgtt ttattcacct gtgctgatgc cattaaatta acattttcct tgttctcctc
      961 agaaaaaaag aggctgcttt gaaacagagt ctcaagatca accaataccg gtttatcacg
     1021 acttgctatg atattttcaa aatgaaaatc tgacccttga aaagcataaa taaatcctaa
     1081 atgcattcca aattggtaat aataatttct tacctgttca atattatcgc acggttcagc
     1141 ctgtacatac tcttgccatc catactcacc ttgatccaag gataaaggtg tttttaaatt
     1201 agtttgataa tactgattga cataatcaat gaccttttca taaaaaacat caatttcaag
     1261 tgaacggggt ttataaacga gtttgttatt ttcaaattca ataataacaa cacttttacc
     1321 gccattatga acatcccctg cattcatatt aatctttctc atttttccga acgaaagatt
     1381 gaatttttgt tggatttttt tatagtcatt aacccaatgt ttaataatag atatagtgaa
     1441 gcgtataaaa tcagaggtgg atctggagat taaatcttgc aatacaggat aattattgag
     1501 tatttcttca acaaatgcgg agtttttcag cctttctgag aatatatatc ataattttta
     1561 gattcatttt tttgatcaaa ctcgtcaaaa gtttgatgaa actcatggat aagtgttttc
     1621 cccgccaaat ggtatatttt tttcttataa ttaattaata tcgattcaac aagacatccc
     1681 ttatccagta gactttcgga tggtattcta tctatttctt taacaatctg agctttaaaa
     1741 atacttatat aatactgcgc aaaaccttcg aaataatcct cttctttaaa aagatttaac
     1801 atagagtttt cataaacata gttatccgaa ttctgtgttt ttttcacatt tatcacttcc
     1861 ttatatattc ttgattgtct ttgacaaaaa agaaaaagaa tatgtacgca tatacatatt
     1921 ctttttcgga tatgtttagt cgttacatgg actgacaata gacgcacact ttgtcgtcgg
     1981 acagcctgct aaagagattg gtattgtgat ggttgtcggc gttacggtca tcggggttgc
     2041 atctgatccc cctgcaagtt tttttaattc ttcttcagtc attggagtca gtgcttgaaa
     2101 atcttttttc atgttaattc ctcctattgt ttgagttttt tataaatttc agtcgttaca
     2161 tggactgaca atagacgcac atttagttgt cggacagcct gctaaagaga ttggtattgt
     2221 gatagttgtc ggtgttacgg tcattggagt tgcttccgat ccccccgcca attcttttaa
     2281 ttcttcctca gtcattactt ccaatgctaa aaattctttt ttcattaaaa atccccccga
     2341 ttgtttttta tacttgcctt tgcggacatg cgcagcctac tgtgatagtt ggacaaatat
     2401 gatttgtgat tggatatgtt gttattgata ctgagttttg ccctccaaca agctctttta
     2461 attcttgttc tgatgtttca tacaacgcgc tgaagttctt tttcatattt catatttcac
     2521 ctcctttcaa gttaataagt ctgctgcagc tgcgattcat atttggcctt aatggtcttt
     2581 aagtttccat tttcaatctc gtagacagat tcggagaatt cgagccattc ggttctatga
     2641 gtaatagaaa ttacagtgat atcctttttg taaatgttat ttaatatatt taattctgta
     2701 tccttatcca aattgcttgt tccttcatct ataaaaagaa tttgcggatt tttcgctaat
     2761 actctggcta ttgagattct ctgccgctgt ccacctgata aggtaatacc gttttctcca
     2821 atcatggtat gataccccat gggcattttt ataatatcct cgtgaataca tgcttctttt
     2881 gcagcttgta caacttcttc cattgttatt ttttcattga aatattttat attatttata
     2941 atagtgtcat taaacagatt gacatcttga acaatataac ccaacgtttc tctcagctta
     3001 accatattaa cgtcctctat tttgaattca ccgtagcaaa tttctcctgc tgttttttga
     3061 taaaggccgg caatgatttt aatcaaagta gactttccgc atccggtttt tccgattaat
     3121 gtgatttttt ctctcggccg aatcattaaa tttatattat tcaaaacata attgtttccg
     3181 ttgtagctga aatcaatatt tttcaagctg atattatgag cggccgggtt aaatagttca
     3241 ctgcttttat catttacttc ctcatctttt tcgtccagca cagcttcaac gcggtctacc
     3301 atttcttcga ctaatttaat agactcaaga ctgccgataa ttgatccaag cggtgacata
     3361 aaccgtccgg caatgttaga aaaagcaatt actgctccga gcgttaggcc tattgatgct
     3421 gctgaccaag tacccgcaat taaaataagt aatggcaaag atagattgat tgcattggag
     3481 accgcaccca gtaaggatga ataattcatt ctttttgaga aataatctag ttgatgttta
     3541 aagttataat ttaattggct ttcaatattc cttgtctctc ctattgtttt tataaacgtc
     3601 atggatctta aaatttcgat tagctggctc tgaaaatttg attgactatt tatttcctgt
     3661 tttgtgaaca tttcaatttt cggaagcaaa attttagtac tcatcacctg tatagctgct
     3721 cccaataaaa ctataaaaga taatatcggg gaataaacaa acatgactat gaaaaataca
     3781 aatataagac tgatatctaa tatcaaagta gacgctaacc tggaaatgac ttcacgaatt
     3841 acagcaatgt tatggattct agttgaaata tccccggcag tattcgcctc aaaaaacttt
     3901 aatggaagac taaatatttt atgaattatt ttctcagtca tactcttatt aatttttaat
     3961 tgcagtttga taataaattt cattctgatt aaggacagac taaagaataa tacgattgaa
     4021 acaataacaa gcatgaaaag cattggtatg ggaagaattt tctcattccc gtcaataaat
     4081 gaatcaataa tatattgagt caaaaaaggg gtcattaagt ttaatgcttg aaaaataaaa
     4141 gtgaaactta tgataacccc caataatttt ttatctttca aaagatattt tccgatcttt
     4201 ctaaatgaag acacatcttt taatgacgaa gcagtcttat cctttctctc aagttcgttc
     4261 tttctgatta acataataga aatgccatta tagaaggttt tgaactcttc taatgtgatt
     4321 gtcagtctgc cagacgaagg gtctataatt ttaacgttat ctgtgccaaa tgcgtcgaca
     4381 actacaaaat gattatgatt ccaatgaaca attagcggat ggtttttatt taactcttta
     4441 agctgcatta tattgtctgt gcggaatgct ttgaaatcat aatcgaatgt ttcagaaatc
     4501 tttttcattt caattaaatc agtgccgtct cttccgataa tttctttatt taatttcaat
     4561 ttgttaggat tgatttttat tccctcagcc ctgctcaaaa ccatggctaa acaagtaata
     4621 ccgcaatcaa attgatttct ttgaagaata accggaagct ttctttttct aattttcata
     4681 aatgtctcct aatgtatcta cacgtcctat ttcaaggttg agaatattcg gcaattccgc
     4741 gtctgctgca tacagcattc catatacgat ccccgccaaa ccaagcatta aattaggtgt
     4801 ttcaacatcc cttcccactc cgcattggta gaaacctata tttttgtctt gtacactctc
     4861 caaaatcaag ttttttccga tatttacaaa ttgactttcg ccagtccttt ttccatattc
     4921 gatcagtatt aaagcatttc ccatgtctcc gtgacagagg ctttgctctc ggccaaaacc
     4981 gtcataaaaa atgttagaaa cggttttatt cagatctttt ttggccactt ccgcaatatc
     5041 agagtgtttt gaatctttca attctaatct acttaataga attccaggag atccatggca
     5101 ccatgcagat gttgcagctt catttaccgt ttttctcaga tcaagccagt taccgtttac
     5161 tttttttgaa ttttcaaaag caagtccttt tcggatgtac atacttatat cttgatgttt
     5221 tgaatgtttc tcgagtaatt gaagggcata tatcattcca gcgtttccat gggaaaaacc
     5281 cgttaacggc ttatttgcaa taccttccca agtgacaaaa tcctcatcaa gaaagatcgc
     5341 ttgtttcatt aaaaatgaac cgcattgttc agccaatgat aaaaagaatg tatcattctc
     5401 tatttcaaac gaacgtatca ttacaataag agcccccgct gtgcccccga ttatatccaa
     5461 ttctttatca taaggaagca aagacggaat aagctgagcg atttgttttg catcctgttt
     5521 atatttttcg cgcttagtat acatatagaa attcattaaa gtatatacta ttgaagatac
     5581 tccggaaaaa gcacctacag acatactgct gtcttcgtcc ggtttcacct caatatcaat
     5641 aaaacgagag acgacatctt tcataatttt ttcggcaatg tccagatact tttctttttt
     5701 cgtgacgcgc cataaaacca ggtaggtgaa agccatcccg gaaagcccgt cgtaaaaggt
     5761 atcacccata acggataagt tccattgaat ttcatcaact ccaataggag tagcgttaag
     5821 ccaagaatac gaacttcctt tatctgtgtg tgctttgtaa gattgattat aaatataagc
     5881 ggccaattcc tctgcttttt ctattaagat actttcttgg ttactactga aaacatttac
     5941 atattgtcct ggttcttttg ttataaattc tttcaaaaca atttgccgat catcctccga
     6001 agcaagcatg gacagttcga taacatagag ctgaaacttt aaatcgtctt ttgataaatt
     6061 tgaaattcgt tcttttacac tttgagctgg tgtttccgga aagtaatttt caattttctt
     6121 attttttgag cttagtaagt ctttctcatt caatttcact ttgaaataag gtatatcatt
     6181 attaattaaa tcgttgaact catatttaac aatagattga tattcatctt cttgctttgg
     6241 tctctcccat atttttgata agaaaatttc tctatcaata gagttgtgta aaaatctagg
     6301 atgaaaactt aattctaata aagcagaata ctttattgtc ggttttgata taaaccgaac
     6361 atatatcttg ttttcgctct tttctattat gcgaatcagc tccgaagcat gttttaatat
     6421 agtcatataa gcttttgaaa aaccttgctt cagttcttcg acataatctt ttgcatatac
     6481 gaatttattc tcaagcatag ggtgattatt agctgtatca atttcgacat agtctcgttt
     6541 gaccgacatt tctgctgtct ttaaattgat aagctgagga actttaatga ccgactttac
     6601 tttccctttc cggcctattc cgctgatgtc ggctttgccc ccaaagaaaa aaggaagcag
     6661 tcctaatgct ctgacagatt catgaagctg tgtttcagct ttttcataag cgtccatccc
     6721 gtcctttttt ttctggtatg caggatgaaa taaggattcc aaatcaatga gaactggata
     6781 gctcccgttg gcaatgagat tttccgaatg aaaatcaacg gctttcaatg catataacaa
     6841 accgatttga gctcctgtac gctgataaaa gttttgaata tcttttagac aattgcatgc
     6901 tttaaaagat ataaattcag tccatccata tccgtctctg ctaaggacat tcggagtact
     6961 caattttata tcatgatctc taattttctc attcaaaaat tcaattatct ttttatataa
     7021 tagatcaatt tctaaacttc tcggcttata aataagcttg ccttcattta atgttatttt
     7081 agtaaccttt ctcccatcag aatgagaatc acccattcct acttcaatgt cccttatttt
     7141 gacttgttct gaaaaaccaa ataaagagag cagttcaggc ttgtcctttt caaaacgcga
     7201 gataaattcc aatatgaatt ttttaaattt tcttagttcg tttccaatca ctcttaataa
     7261 gactggatat tgttgaaaaa agcttttaag atactccgga ctgcacaaaa gagttttatt
     7321 ataataacca tatttttctt caggggtctc ccctgccaaa aaaccttttt cccgattcat
     7381 attcatatcc aatataagtg ttctatagga tacttttaaa atgatttttt ctaattgatt
     7441 tgaaatacta tgatgaaaaa gagccggttg ttccagcaga tagtcataag aaggaaactt
     7501 tgatttttta agtagatcat tgaagtaaga ggacactttt aacgcaaaaa cgtgaaacat
     7561 gatttcttca tttacgtctt cttttttaat agcttggtga gcgatccctt tttttaggtt
     7621 ttcgaaaaca tgaactgtaa aagcggattt atgtaggggg gtttgatata agtttttcac
     7681 tttatcaatt gattgaatgg ataacacatt atgaatgctt tcctgggcca tttgaatatc
     7741 attcttatag attaatttta agtttcgatc aaacagattc tcattttcat cagattgaga
     7801 gacagcagct tttttttctt tacttaatag aatattagtt agcgaattca tttaatattc
     7861 atctcctttt aaaaaagagg gagacagctg gatctcccag agcattggaa atctattttc
     7921 ttattttcgg atttgtttta acaccagcaa gtgtgagtag gacaaagacc gcattcccaa
     7981 gttaacgtac aaagcttacc atcatttcct tgagaaatcc cccgctgttc tgcgcctcct
     8041 cctccgctga tttcatttaa agaaatttcc tcaagttctt ctcttaaatc accggcaaaa
     8101 cgatacattt tctcattcat taatattcct ccccttgagt ttttgaaata tattggattt
     8161 gaatccatat atttctataa atctatgata aacgatcttt tacctatagg caccgaaaag
     8221 tcatattcgg aaaaagcgct ttttttttgc gcgtttccga agtataagtt ataaagaaaa
     8281 tcgggattaa ctgttccgtt aatcccgatt cacttactca tatatagttt tcatagaaat
     8341 taatgaatat cgatttgctt tgatcagtgc ctctgttctg gattttactc cgagcttgtt
     8401 gtacacacca gtaagaatgt attcaaccgc tctttgactg atcaacagct ttgctgataa
     8461 ttcccggttt gtcattccct ccgctacgcc cgctaagata tcttgttctc tttcatttaa
     8521 agtaatatct cttattctat cttcaagctt atcaatgttg aacgtatttg cttctgttct
     8581 tcttaattgt ttaaagagat gagtaggaat aatggtatct ccctcaatga cactttcaat
     8641 tacttttatc atatgctctt ctgttgaaga cttacttatg aacccggaaa caccaacttc
     8701 aaccaaaaga ttgaaatgga cagagatatc aaaaccagta taaattataa ttttttgatc
     8761 gggactctct ctaagaatca tttttgacaa ttccattcca tttaactccg gcatatataa
     8821 atcaagtaaa agtaagtcat actcgtaatg cttaaggtga ttaagtactt ctttacagca
     8881 agacaatatt gttactccca ttttattgct tttttcaaga atggcttttg tcccttgagc
     8941 aacaccaata tgatcatcaa ttaataaaat ctttatcatg tcagcgctcc ctattcattt
     9001 ttcgtactta tttcaaacct taacagcaat ccttcattta cgcctgaaga tatattatga
     9061 ataccattca tacaatttat acgctctttg atccctgtca gtccaaaact gtttgttttt
     9121 gaatttactt tattccaatc aatgccgatt ccattatctt c
//
