LOCUS       gnlProkkaAHBBDOLG_3    14547 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AHBBDOLG_3.
ACCESSION   gnlProkkaAHBBDOLG_3
VERSION     gnlProkkaAHBBDOLG_3
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:31:23
            Original ID  :: gnl|Prokka|AHBBDOLG_3
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 282378
            Orig. end    :: 296925
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14547
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:9547]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9547
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14547
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14547
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(322..1287)
                     /NRPS_PKS="Domain: PKS_KR (32-194). E-value: 3.3e-11.
                     Score: 35.2. Matches aSDomain:
                     nrpspksdomains_ctg3_290_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     181.3; E-value: 3.8e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_290"
                     /sec_met_domain="adh_short (E-value: 6.5e-32, bitscore:
                     105.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIDHSVTNTEQLEQQNPGMKTKIKLKKLKDQVIVITGASSGIGL
                     VTARMAAEKGAKVVLAARNEDALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETAIS
                     TFGRFDTWVNNAAVSTFGHAMDITVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVPGAL
                     INVGSLFGDRGTVIQSTYASAKFVLHGWTESIRMELEKEQAPVSVTLIHPGRIDTPYNE
                     HAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALFPRLTD
                     RLMEKIMYHSQHAERPSKPREESALYDAGCGMHDRGTNKG"
     aSDomain        complement(706..1191)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg3_290_PKS_KR.1"
                     /evalue="3.30E-11"
                     /label="ctg3_290_PKS_KR.1"
                     /locus_tag="ctg3_290"
                     /protein_end="194"
                     /protein_start="32"
                     /score="35.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIVITGASSGIGLVTARMAAEKGAKVVLAARNEDALKELTDELKE
                     KGHDAIWVKADVGKEEDVNRIAETAISTFGRFDTWVNNAAVSTFGHAMDITVEDMKRMF
                     DTNFWGPVYGTRAAVKHYTGRGVPGALINVGSLFGDRGTVIQSTYASAKFVLHGWTES"
     CDS_motif       complement(1096..1188)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg3_290_0001"
                     /evalue="3.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg3_290"
                     /protein_end="64"
                     /protein_start="33"
                     /score="19.6"
                     /tool="antismash"
                     /translation="IVITGASSGIGLVTARMAAEKGAKVVLAARN"
     CDS             1419..1994
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 62.4; E-value: 1.2e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_291"
                     /transl_table=11
                     /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLYH
                     FFPNGKEELAIEAVTYTGKIVEHLIQKSMDESSDPVEAIQLFIKKTASQFDNTESIKGI
                     PVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGG
                     IMLSLTNKDKTPLLLIAEQIPVMVRKKG"
     CDS             2088..3122
                     /locus_tag="ctg3_292"
                     /transl_table=11
                     /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGDL
                     FEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTPHS
                     YRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVADIVF
                     LDEGKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQFIVVS
                     SEGPKGDRIVDHYHEHHTETFYCLEGQMTMWADGQEIQLNPGDFLHVPANTVHSYRLDS
                     YYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPSEPQALRFDRVLQNIEALDLKVDYRADI
                     VSAR"
     CDS             complement(3241..3429)
                     /locus_tag="ctg3_293"
                     /transl_table=11
                     /translation="MSQNKLLFLLFLFSSIVRLFFNTVLSPTVSWKSWTVNIVFILLFL
                     LFLNLTLKERKSKDQVL"
     CDS             complement(3531..5000)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 77.5; E-value:
                     1.5e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_294"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTAADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KKAVKADIKDVKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSNLLESSKE
                     NAKTQQKKLKKQKKSIKNSLDKTKNKVKRKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SFQTNKQNVEQQLDDLRKMKDELDKNSFSQKKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SFDEINSSMKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKATSDGYVNVLTNISPGDYLQAGTAILTIVPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTVKGVITKISPDSISDQSGQKFYIAESTIESKEIEKNNGTK
                     IHLKNGMQTDVSIIVDSKRYIDYFLDVLHLR"
     CDS             complement(5001..7184)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     248.8; E-value: 6.5e-76)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 300.9; E-value:
                     3.1e-91)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_295"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.4e-44, bitscore:
                     144.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 1.2e-236, bitscore:
                     782.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILKKYHCVKQMDDKDCGAACLATILKHYGSKISLAKIRNIAGTD
                     TQGTNVLGVIKAAETLGFSAKGVKADQTAFEQPFPLPAIAHVVLNGQLLHYMVIHKIKK
                     DKIIIADPGKGIITYRKDEFFKIWTGILIFMVPSDTYQQQTDIRSVKKDILNLILHQKS
                     LIIHTALASFIITIFGILSTFYFQTIIDQILPNGLKNSLHIISIGLIIMYLFKVLLTAF
                     RQYLMILLGQKLSISIMLGYFKHVLKLPMKFFSTRKDGEILARFNDTNKVIDAIVSASL
                     SAVLDTFMLIMVGIFLYIQNTSLFIVTLALIPFYILTVWVFMKPYESINDNEMENNAQL
                     TSKIVETLSSIETIKAYNAEYIMSFETEKRFVKYLQSSFKHGVIDNLQSSIKLFLDLIS
                     GALILWIGAWQVIKGNMTIGQLITYNALLAYFLNPLQNIISLQSKLQSASVASKRLGEI
                     LDEEPEIQTSEARVTDPAYIQGPIEINNVDFRYGTRRLILKDITLHIQKGEKVAFVGES
                     GSGKSTLTKLLMKFYTAESGEILINGYHINDIHTNALRESISYIPQESHFIQGSILENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYAQTVDVTTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSREMVTI"
     CDS             complement(7348..7602)
                     /locus_tag="ctg3_296"
                     /transl_table=11
                     /translation="MEFLYILVESVIWILITTIPSKRNLKFRRNLKTLKKHAWFRNLMK
                     DYRPLFLMNSTIQNKIIEYNENIDSKTFKMELEQLAKNI"
     CDS             complement(7880..9004)
                     /locus_tag="ctg3_297"
                     /transl_table=11
                     /translation="MDKFTRKTSFEQWFSPIFSTKLEELVESYQLNYYTKKLHIASFLK
                     LFVFAQLNETESLRAVSETLFSDDLQKATHLEAISFSQLGRRLNQVPTEVFQQVFLDLV
                     AQIHEKSHYEQRRETTTPLKIIDSSTLPLNLKNHKWAEFRKTKSGIKLHLRLVYAEKGC
                     SYPDKAVLTNAKEHDRGQLEVLVDDKECMYVFDRGYLDYERFDRMTDDGYFFVSRLRKN
                     AVIRVIEPFKLPEDSLVFSDEMVLIGTPQNRAENAFRLIKVLDSKGNELHLITNRFDLS
                     ADEIAELYKSRWAIELFFKWLKQHLNIKKFYAQSEQGVHNQVYIAMIVYCLNVLAQLNT
                     NSSRTYLQISRLLKAAPWKSAHLWLRKIVGKTVP"
     CDS             9326..9547
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_298"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.9e-09,
                     bitscore: 32.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQNTNFELLTVEEAEKIDGGGYGSYLIRGVGTGTAVGAALGGP
                     GGAVLGANVGAIWGSAAYGVDALISGHK"
     CDS             9592..9810
                     /locus_tag="ctg3_299"
                     /transl_table=11
                     /translation="MLHNIENSNKMIELSEQEMLNTDGGGWRDLAGAAAGAAVMGGTAI
                     ALGAAAGPVGFAAGVGMAILTRPGHAR"
     CDS             complement(10014..10415)
                     /locus_tag="ctg3_300"
                     /transl_table=11
                     /translation="MIDERIQQEQHKLSYYSFGLSIILFILSFFVSILTQNLFYTQLSI
                     IISFMVVSTYYSIFAIKRGLIIKRKNSNLKHFYIFILSGMFWIIISFLSKEINNMKELL
                     IQLLFFSLFYTVIFLSIRSIIKYSHKQSN"
     CDS             complement(10433..10633)
                     /locus_tag="ctg3_301"
                     /transl_table=11
                     /translation="MNNKVKIERLTLGLTQADLAKKLGITRQTVSLIEKGHYNPSLNLC
                     IRICNVFKKTLDDVFWPSDNL"
     CDS             complement(11520..11720)
                     /locus_tag="ctg3_302"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVMIGDINTDQMEE
                     TVDAIRKKRRTGRILSPRCVR"
     CDS             11823..12074
                     /locus_tag="ctg3_303"
                     /transl_table=11
                     /translation="MKVQHKKELKFYCFITIPSAFVVLTVISFLLQEITFPVTASAFLN
                     ASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG"
     CDS             12242..14122
                     /locus_tag="ctg3_304"
                     /transl_table=11
                     /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFIPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKYIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEENKYKDLFEEMK
                     NILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
ORIGIN
        1 agcctgttta ccattacaaa actcggcaaa caactattaa aagccgatca gcaaaagcgc
       61 cttgaacgtt atgaacagat gctgaaagaa tggtcaacac aggaaaaaga gatgttcggc
      121 gagctgctgc agcgtatgaa caaggctttt atcgattaac agctaaaaaa cccatggttc
      181 cgctggaaca gcatgggttt ttcttatggt cagtgattac ctgcatcgtt tggcggcagc
      241 ccaagccact agtccggcaa caacagccgc cgatacaatg gggcgcttcg tcgcttttgt
      301 gtagtagctt cttgacctca ttcatccttt atttgtgcct ctgtcatgca taccgcagcc
      361 cgcatcataa agagcgcttt cttctctcgg tttggacggt ctttcggcat gctggctgtg
      421 atacatgatt ttttccatca gtctgtcggt cagacgagga aaaagcgcgc ccagcatggc
      481 gatggctttg gcctgtgagc cgatgtacat gtcgcgctta gggtgttcgg cggcaaacag
      541 gatcgcttcg gcgaccgctt ccggcggata gatcatggag cggtaatgag ccggctgttt
      601 gtcgaggtag ctgtgcgcat gctcgttata tggtgtgtca attctgcccg ggtggatgag
      661 cgttaccgag acgggcgcct gttccttttc aagctccatt cggatgcttt ccgtccagcc
      721 gtgaagcaca aatttggcag acgcatatgt ggattgaatg actgttcccc tgtctccgaa
      781 caggcttcct acattaatga gtgcgcccgg cacacctctg ccggtgtagt gtttgacagc
      841 cgctcttgtt ccgtaaacag gtccccagaa atttgtgtcg aacatgcgct tcatgtcttc
      901 gacggtgatg tccatggcat gtccgaaagt cgagacggcc gcattgttga cccatgtgtc
      961 aaagcggccg aatgtgctga tcgcggtttc tgcgatgcgg ttgacgtcct cttcttttcc
     1021 gacatccgcc tttacccata tggcgtcgtg ccctttttcc ttaagttcat cagtgagctc
     1081 cttcagcgcg tcttcatttc gcgctgctaa cacgaccttt gcgccttttt cagctgccat
     1141 tcgtgccgtg acaagtccga ttccgcttga agcgccggta atgacgatca cctgatcctt
     1201 gagttttttc agtttgatct tcgttttcat gccggggttc tgttgttcaa gctgctctgt
     1261 attcgtgact gaatgatcga ttgtcattga gagatccctc ctagacgctg tttttgtaca
     1321 tttaccccat ccgggagggt cttacccctt ttgacaatca cagggttctt ttttatatta
     1381 tataagtcgc tctaccatac ctaggaggga atgttttaat gactagcaga ggagattcac
     1441 gtgaaaaaat ccttcacacg gcgtcacgtc tgttccagct gcaaggatat cacgcgacag
     1501 gtttgaacca gattgtaaaa gaaagcggtg ctcctaaggg atcgctttat cacttttttc
     1561 cgaatggcaa agaagaatta gcaattgaag cggttacata tacaggtaag atcgttgaac
     1621 atctgataca gaaaagcatg gatgaatcct ctgatcctgt tgaagcgatt cagcttttta
     1681 tcaaaaaaac agccagccaa tttgataaca cagaaagcat taaaggtatt ccagtcggtt
     1741 tgctggcgag tgagacagcg ttaatcagtg aaccgctgcg gacggtttgc atgaaggtgt
     1801 ttaaaagctg ggaagcggtt tttgccagaa aattaatgga aaacggattt gcagaagaag
     1861 aagcaaatca gcttggaacg ctgattaatt cgatgattga gggcggcatc atgctttcgt
     1921 taacgaataa agacaaaacg ccccttcttc tcattgccga acaaatacca gtgatggtga
     1981 gaaaaaaagg gtagcatttt gttatccttt ctcctacaat tatatagaac ggtctagaca
     2041 aataaatgat aatatataga ctggtctaaa ttggaggaaa cgataatatg aaaacattat
     2101 gtacacattc attgcctaaa gaaaaaatgc cttatttgct ccggagcgga gaaggcgagc
     2161 gctatctgtt cggcagacag gttgccacgg tgatggcgaa tgggaggagc acaggtgatt
     2221 tgtttgagat cgtgcttctt tccgggggaa aaggagatgc ctttccgctt cacgtccaca
     2281 aggacacaca tgaaggaatt ctcgttttgg acgggaaact ggaactgaca cttgatggtg
     2341 aacgctattt attaatatca ggtgattatg cgaacattcc ggcgggaaca ccgcacagct
     2401 accggatgca gagccacaga acaagactgg tatcttacac gatgaaagga aacgtagcgc
     2461 acttgtattc cgttattggg aatccgtatg atcacgctga acatccgccg tacgcaagcg
     2521 aagaagtctc aaacgagcga tttgcagaag cagccgctgt agcggacatt gtatttctag
     2581 atgaaggaaa gcctgcatgt tcggccaaat tagcagaact tacagagctg ccagatggag
     2641 ccgttccata cgttcttgaa tctggagaag gagatcgcct gttgactgga gatcagcttc
     2701 accgcattgt ggctgcacaa aaaaatacag atggccagtt tatcgtcgta tcctctgaag
     2761 gccctaaagg tgaccgaatc gttgatcact accatgaaca tcatacagaa acattttatt
     2821 gccttgaagg ccagatgacg atgtgggcag atggccagga aattcagctg aatccgggag
     2881 atttcctgca tgtccctgca aataccgttc actcctatcg ccttgattct tactatacaa
     2941 agatggtggg cgtattggtt cctggtttat ttgaaccgtt tttccggacg ctaggcgacc
     3001 cgtatgaagg ccacatcttc ccaagtgagc ctcaggcttt gcgctttgat cgcgttttgc
     3061 agaatatcga agcattagat ttaaaggtag attatcgggc tgatattgta tcggctcgat
     3121 gaagggaagg cgcatgcgcc ggaagtgctg gcgagggagt ttttgcagtt tttggatgtg
     3181 aagaagtata aggttgtttt gctttgaagt gcccggagac ttgatccggg ctttgggtcg
     3241 ttataatact tggtcttttg attttctttc ttttaaggtg agattgagaa atagaagaaa
     3301 caaaagaata aaaacaatat tcaccgtcca agacttccag cttacagtgg gggacaatac
     3361 tgtattgaag aaaaggcgaa cgatagaaga gaataaaaag agtaaaaata acagtttgtt
     3421 ttgagacatg attctatacg tcctctgcct ttcttataaa aaataaaatg cctcaaagca
     3481 gatcctcatc tgcttttgag acatatatgc actttttctc tagatggaaa ttaacgtaag
     3541 tgtaatacat ctaaaaaata atcaatatat cttttggaat caacgataat tgatacatca
     3601 gtctgcatgc cattttttaa gtgtattttt gttccgttat ttttttcaat ttctttactt
     3661 tctattgtgc tttcagcaat ataaaatttt tgcccgcttt gatcacttat actgtctgga
     3721 cttatttttg taatgacacc tttaacggtt tgatttgtat tttcaatatg gaatcttact
     3781 tcatcttttt catttatatt tgtgatctca tgactcggaa tataaatgtt agctttaagc
     3841 ttctctttat caggaacaat agtcaaaatg gcggtgcctg cttgtaaata atcacctgga
     3901 gatatatttg ttaatacatt aacatagccg tcacttgttg cttttatttt atatttttct
     3961 aattgtaaat ctatcatctt tagatcatct tcttttgatt taagagtggt ctgaagatct
     4021 gtttgctttt gagatgtttg atttagcaaa tttgttttaa gctgttcaat tgaaagctta
     4081 taatttgttt cctctgagtt atcggaatca ctgtcagaat cgtcactttt cattgaactg
     4141 ttaatctcat caaatgattg atttaattcg tctttttctt cgcttagttt tactagcata
     4201 tcttgtttta aactttcaag ctgtccgttt agattctctt tcttctgtga gaaactgttt
     4261 ttatcgagct catctttcat cttccgtaga tcatcaagct gctgctctac attttgtttg
     4321 ttagtttgaa aactattata gtaagaactg tacttatcat cctgtttggc aaaggattta
     4381 ttgtttttaa tggagtcttg cagatcagaa attctttgaa gctttcgttt cactttgttt
     4441 tttgtcttat cgagactatt ttttatgctt tttttctgct tcttaagttt tttctgttga
     4501 gtttttgcat tttcttttga tgactctaac aaattgcttt gtttttcgta tgagagatat
     4561 tgatcttgat aaccccaatg atcgtcctcg ctgaataaat ttttgtcatt ttcaatactt
     4621 ttttttagag ttttgtttaa cgcagcttgt tcttttacat ctttgatatc tgctttaaca
     4681 gcttttttct gcgcttggat ttcagtattg tctagagtta atagagtatc cccctttttc
     4741 accttatcaa cctgtttaat atcaactgtt tttactttgc cggctacttc gtttgttacg
     4801 ttgctgttag gtttcgtata ttggatgtca gctgccgttt ttagaatcac ttctttcttt
     4861 ccatagaaac taaaaacaat acatgcaata agtaaagcta tcagtatata tgtaaagaaa
     4921 acaccaattg gtttgggttt tgattcgtag aattctctgc tatccttcaa atcatgtaaa
     4981 ttgaaaaagt tacgtttcat ctaaattgtc accatctctc tcgatggcat ttggttctcc
     5041 cacaactcat agtactttcc ttttttcttc aataaatcat tgtggttccc atactctatg
     5101 atttctccat tttccatgac aaatattttg tcgcaattca taattgtact taaacgatga
     5161 gcaattataa ttgtagttac atcgacagtc tgagcgtaaa tcatctttga tattccctgt
     5221 tcggtcgtcg tatcgaggtt gcttgttgat tcatccatta taagaatgtt aggttttctt
     5281 aataatgccc tggcaattgc aagtctttgc ttctggcctc cagataaatt agacccgttt
     5341 tcctctacga gagtatcgta tctcattggt aaatcattga caaaatcatg tacatttgtt
     5401 tgtttgcaaa cttctataat ctcttcgaag gtaaaacttc ctgagttccc aagcaaaagg
     5461 ttttcaagaa ttgatccttg tataaaatga gattcttgag gtatataact tatgctttcc
     5521 cttaacgcat tggtgtgaat atcatttata tgataaccat tgattaaaat ctcacctgat
     5581 tcagctgtat aaaatttcat taaaagctta gtcaaagtag attttcctga accgctttct
     5641 ccaacaaagg caactttctc tcctttttga atatgcagtg taatatcttt taagatgagc
     5701 cttcgagttc cgtatcgaaa atcaacattg tttatttcaa tagggccttg tatataggct
     5761 ggatcggtaa cccttgcttc agatgtttgt atttcaggtt cttcatctaa aatttctccc
     5821 aatctctttg aagcaaccga agctgactga agtttggatt gaagtgagat gatattttgt
     5881 aaagggttca aaaaatatgc caatagtgcg ttatatgtaa tcaactggcc aattgtcata
     5941 tttcccttta tgacttgcca agcgccgatc catagtatca atgcaccact tattaaatct
     6001 agaaacaact taatagaact ttgaagatta tcaattacac cgtgtttaaa agaagattgc
     6061 aagtatttca caaatcgctt ttcagtttca aatgacataa tatattcagc attgtaagct
     6121 tttattgttt ctatactact taatgtttca acaatttttg aagtgagttg agcattattt
     6181 tccatttcat tgtcattaat actctcatag ggcttcataa aaacccaaac agttagaata
     6241 taaaagggga ttaaagctaa tgttactata aacaaagaag tattttgaat atataaaaag
     6301 atcccaacca tgattaacat aaatgtatcg agcactgcgg acaaggatgc gctgacaata
     6361 gcatcaataa ctttatttgt atcattgaat ctagctaaaa tttcaccatc ttttctagtg
     6421 ctaaagaatt tcataggcag cttaagaaca tgcttaaagt aacccagcat aatggatata
     6481 cttaattttt gacctaatag aatcattaaa tattgtctaa aagctgttaa aagaacctta
     6541 aataggtaca ttattataag tccaatagaa ataatatgta aagagttctt caaaccgttg
     6601 ggcaaaattt gatcaatgat tgtctgaaaa taaaaagtgc tcagaatacc gaagatcgta
     6661 ataataaaag atgctaatgc tgtatgtata attaaagatt tttgatgaag tattaaattt
     6721 aaaatgtctt ttttaacact tctaatgtct gtttgttgct gataagtatc acttggaacc
     6781 ataaaaatta aaattccggt ccaaatctta aaaaattcat ctttcctata ggtgattata
     6841 ccttttcctg gatcagcaat aataatttta tcttttttaa ttttgtgtat gaccatgtaa
     6901 tgcaataatt gaccatttaa aaccacatgt gcaatagctg gaagagggaa cggttgttcg
     6961 aaagctgttt gatcagcttt aactcctttt gcagaaaacc caagggtctc tgctgctttt
     7021 attacaccaa gaacattagt accttgtgta tctgtgccag caatatttcg aattttcgct
     7081 agtgatatct ttgatccata gtgctttaga atcgttgcta aacacgcagc accgcaatct
     7141 ttatcatcca tttgttttac acagtgatat ttttttaaaa tcattttcta atctccgtag
     7201 ttaaaaaatt taatccgtaa aattatgcgg aactttataa tcataatata acagtaatac
     7261 atatatcgat aatttaaggt gaaatataac ttttttgtgt aaaggtacga tgaaatttag
     7321 attattaatt gtacatactt ttcacactta tatgtttttt gctagttgtt ctaactccat
     7381 cttaaaagtt ttagaatcaa tattttcgtt atattcaata attttgttct ggatagttga
     7441 gttcattaaa aacaggggcc tgtaatcttt cattaaattg cgaaaccaag catgtttttt
     7501 taatgttttt aagtttcttc taaatttcaa gtttcttttt gatggtatgg tagtaattaa
     7561 aatccatatc acactctcaa ctaatatgta caaaaactcc atcaaattaa cctccttatg
     7621 ctaataaaac attatgatat taaaattaat ttttcataaa aaatcctttt ctagattaac
     7681 ataaaaaaaa ctttggttaa agtttcaagt agttagttat tatatgaatt tagtcactag
     7741 tgttgcataa attttgactg aattttctgc tttcttgttt ttgctcatga gaagaaaaac
     7801 aaagacattt gaatagaggt agttaacatc cattttttta ctataatctt tgacgagtgc
     7861 aacagacctg tgaaattctt tagggcacgg ttttccctac gatttttcgt agccataaat
     7921 gagcggattt ccatggtgcc gctttgagta agcgactaat ttgtaagtac gtccttgaac
     7981 tgttcgtgtt cagctgtgcc agtacattta ggcaatatac aatcattgcg atatacactt
     8041 gattatgtac gccttgttcg ctctgcgcgt agaacttttt gatgttcagg tgctgcttca
     8101 gccatttaaa aaatagctcg attgcccagc gcgacttata taactcagcg atttcgtcag
     8161 cgcttaaatc aaatcgattc gtgatcagat gcagttcgtt tccttttgaa tcgagcactt
     8221 tgatgaggcg aaaagcgttt tctgcacggt tttgtggtgt accaatcaaa accatttcat
     8281 ctgaaaacac aagcgagtct tcaggcagtt taaatggctc gattacacga atgacagcgt
     8341 tttttcgtaa gcgtgacaca aagaaatacc catcgtctgt catgcggtca aatcgttcat
     8401 aatccaagta accccggtca aagacgtaca tgcattcttt gtcgtcaacg agtacttcca
     8461 gctgaccacg atcatgttct ttcgcgtttg tcagcaccgc tttatctgga taggaacagc
     8521 ctttttctgc gtaaacaaga cgtaaatgaa gcttgatgcc cgactttgtt ttacggaatt
     8581 cagcccactt atggtttttc aagttcaatg gcaacgtact cgagtcgata attttcagtg
     8641 gtgttgtcgt ttctcggcgc tgctcataat gtgatttctc gtgaatttgg gcaactaaat
     8701 ccaaaaatac ctgttggaac acttcagtcg gcacttgatt taatcggcgt ccgagctgcg
     8761 aaaagctaat cgcttctaaa tgcgtcgctt tttgaaggtc gtcagaaaat aatgtctcac
     8821 tgactgcacg cagactctcg gtttcattga gctgagcgaa tacgaacaat ttcaagaatg
     8881 acgcaatatg tagcttcttt gtatagtaat ttaattgata gctttcaact aattcctcga
     8941 gttttgtgga gaaaatcggt gaaaaccatt gttcaaatga tgtttttcgt gtaaacttat
     9001 ccatgcttat tgtcctttac tttggatttg gatggtttat taccgcccta ccattataaa
     9061 ggcttttttt atgcaaagat aaaattactg aaaatttaga tttttataaa tcgttgaatt
     9121 attttaatgc gacactagtg gaatttagtc aaatattcaa ttacatagcg actctaggat
     9181 attaagtaat taaagaaatt ataggcattt tagatgtatt aagtaatata aatttggtta
     9241 taactgttga aaaaacttca aattacattt atagtaatat aagtcgacaa taatttacca
     9301 agttcggact taggaggagt aaactatgaa aaagcaaaac accaattttg aattattaac
     9361 tgtagaagaa gctgaaaaga tagatggtgg gggttatggt tcttatttaa taagaggagt
     9421 tggaacaggc actgctgtgg gagcagcttt aggcgggcct ggcggagctg ttttaggtgc
     9481 taacgttggg gctatctggg gttctgcagc gtacggtgta gatgcattga tttctggaca
     9541 taagtaatta aaatttcact aatataaacg taaaaaaaca ggaggtttag catgttacat
     9601 aatatcgaaa atagtaataa aatgattgaa ttgagtgaac aagaaatgtt aaatactgac
     9661 ggaggagggt ggagagattt agcaggagct gccgcaggag ctgcagtaat gggtggaacg
     9721 gccattgctt taggagcggc tgctgggcca gttggatttg ctgcaggagt aggaatggca
     9781 atcttaactc gcccaggtca tgctagataa cttatcttat agaaagctgt cgataaatga
     9841 cgacagcttt ttcttttaca attatttgag ggctcaactt cataccttta ccaacagttt
     9901 tgtagtgagg ggttatgtta atactttgaa aaaatctgta ggttaatata ctcctattac
     9961 tattagtgtt aaacactttc cttaaaaggt tataacctaa tttaaattat gtactaatta
    10021 gattgtttat gtgaatactt aattatagaa cggatgctta gaaatataac agtgtagaag
    10081 agtgaaaaaa atagtaactg aatcagtaat tctttcatat tatttatttc tttagaaaga
    10141 aaacttatta ttatccaaaa cattccgctc agtataaaaa tataaaagtg ttttaaattg
    10201 ctgttttttc tctttattat taagcccctt tttatagcaa aaattgaata ataagtgcta
    10261 acaaccataa acgatataat tatacttaac tgggtgtaaa ataagttctg ggttagaata
    10321 gaaacaaaaa aactaagaat aaataaaatt atagacagac caaaactgta ataactcagt
    10381 ttatgttgtt cctgctgtat tctttcatca atcattctaa ctatgcactc ctctataaat
    10441 tatctgaagg ccaaaaaaca tcatctaaag tttttttaaa aacgttacaa attcttatac
    10501 ataaatttaa actaggattg taatgacctt tttctattaa gctaacagtt tgtcttgtta
    10561 tcccaagttt tttagctaaa tcagcctgag ttaaaccaag agttaatctt tcaattttaa
    10621 ccttattatt catggcatcc tcctttatta atgattgtaa catatatatt actttatgta
    10681 caatatatat tacattgata ggatgaaatt gttaaaactg aaaggagtct tttggagata
    10741 ttcttaaatg aaacatatta ctgagatagt cggagcctga ctaatattca atgttcaagg
    10801 ttttagattg aaaaaagtca taaataggag tgtttttttt gtttcgtttg cattcggaaa
    10861 ttaaaaaaag agggcgtttt atccctcttt gagctaacgt tatttcgttt cttccttcca
    10921 tttctcatca atcagcatct tcccaggcca tgtatatgcc atgatgccgc cgtctgcggt
    10981 gatgtcctct cctgtgacgt atgagctgtc atctgacgcg aggaacaggg ccactgtcgc
    11041 catttccttc ggctggccga ggcggccgag cggcgtgacc catttgttgg cttcgcggga
    11101 ttattcaccc atttcctgtt ctttggtgcc tgctaatttg tcaatcagcg gggtttcgat
    11161 cgtacccggt gaaatggaat tgacgcggat gccgttccgt gcgtagtcga tcgccatcgc
    11221 ttttgtcagg ttggtgatgc cgccttttgc tgcgttgtag cccgagcggt caaggtccgc
    11281 ggcacggcct gacatgagga ggtgttgatg atggagcctc cattttcgag catgagcgga
    11341 atcagatatt tgctgcaaag gaatgtgccg cgcaggtcga cagcgataat gcggtcaaac
    11401 aggtcaaccg gatattcgtg cacctttccg ccttcctgat caacgccggc attattaaac
    11461 agaatatcaa tcgttccgca gcatccttga tttgatcagc aaatgctttc acactgtttt
    11521 catctgacac atcgaggtga aaggattcgg cctgtcctcc gtttttttct gattgcgtca
    11581 actgtttctt ccatttgatc tgtattgatg tctccgatca ttacacgcgc gccttcattg
    11641 gcaaaaacct ctgccgtcgc ttgtccaatg cctgtcgcgg cgcctgtgat cactgcggtt
    11701 ttgttttcaa gtcttcccat gacgagacct cctttttcta tttggcagtg ataaacatga
    11761 agaaaaagaa ctgccaacat atgttaagat ggattgggaa attgttggga gggttgtgtg
    11821 ttttgaaagt acagcataag aaggagctca agttttattg ctttatcacg attccatcgg
    11881 cgtttgttgt gctgactgtc atctcttttt tattgcaaga gattacgttt ccggtgactg
    11941 caagcgcatt tctgaatgct tcatggcata atcttttgtt tttgataccg ttcggtttgt
    12001 ttttctaccc ggtgcatata tggatgaagc gggagtttgg ccgctggaat gacacagaaa
    12061 aaaagagagg atgatgaagc ctctcttttt tatgagaatg agtgagaaaa agagtgaaaa
    12121 caaatccaaa taatgttaaa tttacatata tatgcatcta tcaatctaat tgacaattgt
    12181 catcttatgt gataaataga tgctaaaaag ggtttacata atggtaaagg agcgatcaag
    12241 agtggcgaaa aaagagttta aagcagagtc taaacgcttg ctggatatga tgattaactc
    12301 catttatacc caaaaagaaa ttttcctgcg cgagttaatc tccaattcga gtgatgcgat
    12361 tgacaaaatc tattacaaag cgcttacgga cgatgcgctt acgtttgata aagacagtta
    12421 ctacataaag gtcgcagctg acaaagatgc gagaacatta accatctctg atacggggat
    12481 cggaatgaca aaggatgagc ttgaacagca tcttggaaca attgcaaaaa gcggttccct
    12541 cgcgtttaaa aaggaaaacg agctgaaaga cggacatgac attatcgggc agttcggtgt
    12601 cggtttttac gcggcattta tggttgccga tgtcgtgaca gtcatcagta aagcgcttgg
    12661 cagcgaagag gcttataaat gggagtctgc gggtgcagac ggctatacaa ttgagccgtg
    12721 tgaaaaggat tctgtcggta cagacattat cctgaaaatc aaagagaaca cagaagatga
    12781 cagctatgac gaattcttag aagaatatcg tttaaaagcg atcatcaaga agtactccga
    12841 cttcattcgc tacccgatca aaatggatac gaccattaat aagccgaagg aaggcagcga
    12901 aaatgaattc gaagaggtgc aggaagagca gacggtcaac agcatggtgc cgatctggag
    12961 aaaaaacaaa agcgagctga cagatgagga ttatgaaaaa ttctatgctg aaaagcatta
    13021 cgggtttgat aaaccgctga cacacgttca tatcagtgtg gatggagcgg ttcgctacaa
    13081 cgcgattcta ttcatccctg aaaacatgcc gtttgactac tattccaagg aatatgagaa
    13141 aggcttggag ctgtattcca atggcgtgct gatcatgaat aagtgcgcag acctgctacc
    13201 ggaccacttc agctttgtga agggcatggt cgattccgag gatctgtcgc tgaatatttc
    13261 cagagaaatg ctgcagcatg accgccagct gaagctgatc gcgaaaaaca tcagcaagaa
    13321 aatcaaaagc gagctgcaaa gcctgttgaa aaaagaccgc gagaaatacg agacgttcta
    13381 caagtcgttt ggcagacagc tgaaattcgg cgtgtataat gattttggcg cgaataagga
    13441 tcaattgaag gatctcctat tattctactc ttcaaaagag aaaaaactgg tcagcttaga
    13501 cgagtatgtt tccagaatgc cagaggagca aaaatacatt tattacgcga ccggtgattc
    13561 ttacgaccgc attgagaaac tgccgcaaac ggaaatggtg gcggacaaag gctatgaaat
    13621 cctctacttt actgaggaca tcgatgagtt tgcaattaaa atgctggctt cttatcagga
    13681 aaaagaattc aagtccgtat caagcggaga ccttggcata gacacggatg aggatcaaaa
    13741 gcagtccgag gaagaggaaa acaagtataa ggatctgttt gaggaaatga aaaacattct
    13801 gtcagacaaa gtgaaaaacg tcagaatctc aaaacggctt aaatcacatc cagtctgcct
    13861 tgctgctgac ggcgaagtga caattgagat ggaaaaaatc ttaaacgcaa tgcctgacag
    13921 ccaaaatgtg aaggcggaaa aagtgctgga aatcaacccg aatcacgagg tattccaaac
    13981 gctgcaggac gcgtttgaac aagataaaga gaagctgagc ctgtacacaa accttctgta
    14041 caatcaggcg cttctcattg aaggcctgcc gattcaggac cctgttgaat ttacgaacaa
    14101 tatttgcaag gtcatggtgt aaacagaaaa aggaatcgtc ccttaaggag acgattcctt
    14161 ttttttataa agtacgctca ttcagcactt ggttttgggt gcttttcttc tttttaaacc
    14221 gttttttcag gcttgcttca atttcctcca agcttttccc tttggtttcc ggtaccatgt
    14281 agaacgcgaa gaaaaatgag agaagacaaa tgactgagaa aaccataaag acccatgcga
    14341 tgcccatcgc gcttagcatc agcgggaaga caagcgacac gatcaggtta gccgccgata
    14401 acaccaaagt cgtgaaccct gtcgcggctc cgcgtgcttt ggatgggaag agctcaggca
    14461 tgagcaccca cactaccgga ccccatgtcg cctggtaaaa gacgatatag acacctagaa
    14521 agactactgt catccacgct gttgaag
//
