LOCUS       gnlProkkaDAAPCEDA_23   11683 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAAPCEDA_23.
ACCESSION   gnlProkkaDAAPCEDA_23
VERSION     gnlProkkaDAAPCEDA_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:59:27
            Original ID  :: gnl|Prokka|DAAPCEDA_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 129212
            Orig. end    :: 140895
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11683
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11218]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11218
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11683
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11683
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(175..1071)
                     /locus_tag="ctg23_147"
                     /transl_table=11
                     /translation="MSSKYAVWLAFFLNLSFSIVEFIAGGIFVSSAVLADSVHDLGDAL
                     AIGLSAFLETISNREEDSRYTLGYKRFSLLGALVTAVILMTGSGMVILENISKLFHPQP
                     VNDEGLLWLGIIAISVNLLASLVIRKGQTKNESILSLHFLEDTLGWLAVILMAIVLRFT
                     DWYILDPLLSLAISFFILSKAIPRFWSTLKIFLDAVPEGVDIKQVKNDLEQLDNVASIN
                     QLNLWTMDGLEKNAIVHVCLEHVKHIEVCKESIRDLLKESGFQNVTIEVDEDLATHQAH
                     KRNIEELEAESEQQHHH"
     CDS             1169..1744
                     /locus_tag="ctg23_148"
                     /transl_table=11
                     /translation="MYVTEQFVHSVHMTAQDRRITKTRKAIYQAFLYLLNQKDYEAITV
                     QEIIDLADVGRSTFYSHYESKELLLDELCQKLFHHLFERTQYLSPQDYLAHIFQHFKKN
                     QDHVTSLLLSKNDYFIRQLRKELEHDVYPMVADELIQSHPNIPHSYLKHLVITNFIETL
                     TWWLKKGKSYSEQEVVQFYLEILNVASN"
     CDS             1783..1995
                     /locus_tag="ctg23_149"
                     /transl_table=11
                     /translation="MLLLILLGIFTAFLSLAFALLHLMASLSELRKHKNTLGNRLLLIG
                     SNLATFSHPLLPFADCCFIPLADRS"
     CDS             complement(2172..2894)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     76.2; E-value: 4.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_150"
                     /transl_table=11
                     /translation="MRGRVSSYLADFSKLDNVYRFVEEIKRDFQRIDILFNNAGLYAGK
                     ERKASGENVELTFMLSVLVPYIFITELIPLLEKLPDGLVINTSSYMHHFAKVKDLDFGF
                     EKEYNPGLAYNNSKLYTIWMTRYLARDFFLKGSNTTINAYHLGLILTNLGNNSSDKKTE
                     KSLFGRLMKSLSKDLDQGIETGYYLTLSEEVSGLTGYYFDEKKVKSVSEKGYSFEKTQK
                     LMNYCQEKVKMFKEKQNV"
     CDS             3146..3850
                     /locus_tag="ctg23_151"
                     /transl_table=11
                     /translation="MTEKGIIISEKLADLAGISVGDEVTVQNSQDKDIKLKVAGISEMY
                     MGYFIFMNESTYKDAFGKEASQNATILTLKDHSDKNVEQTASRFMSLDGVKGDVQNTTL
                     KAQIKTIVNSLSRVMGVLISVSILLAFVVLFNLTNINVAERIRELSTIKVLGFFNKEVT
                     LYIYRETICLSIIGILVEFGLGLGLHQYMVDVIPPENIMFNPNLGWLIYAVPTLVIIII
                     LTGSGYLCEPTP"
     CDS             4107..4997
                     /gene_functions="other (smcogs) SMCOG1206:transposase
                     (Score: 305.3; E-value: 1.1e-92)"
                     /gene_kind="other"
                     /locus_tag="ctg23_152"
                     /transl_table=11
                     /translation="MRLIKNNTELIGIKDQNIKISLVFETDTHIEIQAKLDYPAPSCPH
                     CHGKMIKYDFQKPSKIPLLEQAGTPTLLRLKKHRFQCKSCRRVTVAETSIVEKNCQISN
                     LVRQKVTQLLTEKVSLTDIASRLRVSTSTVYRKLDQFTFKKHYDKLPAVMSWDEFGFKK
                     GELAFVAQNYETNQLITILDNRRQTTIRNYFLKYPLKVRQQVQFITMDMSGAYIPLARK
                     LFPNAKIVLDRFHIIHHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQKDSRKLIS
                     QLFLFKDFPPNFSTT"
     CDS             complement(5213..5329)
                     /locus_tag="ctg23_153"
                     /transl_table=11
                     /translation="MNVQSDEDTLLKVDEVSKTEAQAFDVFDQTISRFKFRV"
     CDS             complement(5417..6136)
                     /locus_tag="ctg23_154"
                     /transl_table=11
                     /translation="MSEAIKLFQYNTLGALMAGLYGGTLTVGELLEHGDLGLGTLDSID
                     GELIVLDGKAYQAKGSEGKVEVVEVSPDEKVPYAAVVPHQAEVIFRQRYEMTDKELEDR
                     IESYYDGVNLFRSIKIKGHFKHMHVRMIPKSNADIKFADVATRQPEYEVDDISGTIVGI
                     WTPEMFHGVSVAGYHLHFISDDLTFGGHVIDFVIENGIIEVGPVDQLDQRFPVQDRQYL
                     FAKFNVDEMRKDITKAE"
     CDS             complement(6152..7828)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 503.4;
                     E-value: 1.4e-152)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_155"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-51, bitscore:
                     168.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.9e-46, bitscore:
                     149.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEEKQLYGADLVVDSLINHDVEYVFGIPGAKIDRVFDTLEDKGP
                     ELIVARHEQNAAFMAQGVGRITGKPGVVLVTSGPGVSNLATGLVTATDEGDPVLAIGGQ
                     VKRADLLKRAHQSMNNVAMLEPITKYAAEVHDANTLSETVANAYRHAKSGKPGASFISI
                     PQDVTDAPVSVKAIKPMTDPKLGSASVSDINYLAQAIKNAVLPVFLLGNGASSEAVTYS
                     IRQILKHVKLPVVETFQGAGIVSRDLEEDTFFGRVGLFRNQPGDMLLKKSDLVIAIGYD
                     PIEYEARNWNAEISARIIVIDVEPAEVDTYFQPERELIGNVEASLNLLLPAIQGYKLPE
                     GSVEYLKGLKNNVVEDVKFDRQPDEGTVHPLDLIEVLQEQTDDDMTVTVDVGSHYIWMA
                     RYFKSYEPRHLLFSNGMQTLGVALPWAISAALVRPKTKVISVSGDGGFLFSAQELETAV
                     RLKLPIVHIIWNDGHYNMVEFQEEMKYGRSSGVDFGPVDFVKYAESFGAKGYRATSKAA
                     FASLLQEALTQAVDGPVLIDVPIDYKDNIKLGETILPDEFY"
     CDS             complement(8082..9254)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 61.4; E-value: 1.2e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg23_156"
                     /transl_table=11
                     /translation="MKIKKYAALSIYFNRFSSLISEYGYTILINILLSRISVQLVMYFW
                     VVKCLAAIVTNRINISNSKLSRKYLLILLEITKAILLFLLGFGLNHIIVLLVVFIIEVV
                     NVLFSSLLYSCVPIIIDKDSLIKFNARYTSIGSVSYFLAPLFVGLFINKSHFLLFAVYA
                     LLLIVGATSLLFLPNISTLNLKEERKKQNLNITLFNILRSKKIALVLLSGVIVGSIGVV
                     YDTYEVVYLTKYLGISDSMYSFSLSFLAVSFLVMSFLLSFVKQISSHMKAFALGLSFYV
                     LYLLLFSTSSNIYTVLMSYVFLAIGQTMMGIIETNYFQLSLNMKELQKLYIYSETLHSV
                     FSGIAVLVIGSFAFLSSHLVLVFRSLAVFALFILLCYCVFVNLKKLSIDK"
     CDS             complement(9261..10004)
                     /locus_tag="ctg23_157"
                     /transl_table=11
                     /translation="MKILSIIYDGGSRIPGARFAPTKYYQEAMLYDRKDSDIITINLGN
                     QDLFSIDLESLSRTIAESKVQIALGGDHSVTYLLAKATVREGAYLIVLDAHLDYFKDFE
                     SVVKNWNFLSFLTDIFEKIIIIGERNFEFPSSFDNKIIILSMEEYWLNKSRVLKKLDSY
                     IDESKDIYLSIDIDVLDPSVFDSVSYPIIGGFQMNDFLGIISKILCSDKVYFCDIVECN
                     PMVGSDNAHIFYQMIQFVKSKLRRI"
     CDS             complement(10001..11218)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Streptide_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_158"
                     /sec_met_domain="Streptide_RRE (E-value: 4.9e-16, bitscore:
                     52.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.2e-21, bitscore: 70.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.9e-10, bitscore: 32.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-11, bitscore:
                     37.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.1e-09, bitscore: 29.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNVYSIFFNWYNKQGILRNNRNNKLFSLNLATFLALKFMYQFS
                     LKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKIPLKVIQIEVTNKCNLRCMH
                     CYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLLQGLSEIIEEVLKEGMCTTI
                     FTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRGRGTFKRTIKNIEYFRSLGV
                     PVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFERNNRLSISDEEFNNAILCIP
                     NIQANCNNISESTFESFYCGAGNSYVFINSSGDVGFCPTLSSTKFCGGNINEKTLNDIW
                     INSKFFNHIRNVRCKYYNECPANYVCQGGCRSRAQFFGGSIGSPDIQECKLAYNLTGIK
                     PKSMSL"
     CDS             complement(11301..11450)
                     /locus_tag="ctg23_159"
                     /transl_table=11
                     /translation="MQVSDAIAQIELAEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             complement(11510..11683)
                     /locus_tag="ctg23_160"
                     /transl_table=11
                     /translation="MCGKRSHRNKSLSSNVLQLYYNGFIPFCVYTTYFTLPANQFNKTI
                     SKHFQLNFIDKE"
ORIGIN
        1 tccttcatag gtaatctctt ctggtgaccc aaaggtcatc atcaacacag ctctcttact
       61 cataattaat ccttgttcta catttgttct attttatcat gaaaaggatc actttaggga
      121 acttggtatc aaaataactc ttaaaggtag actctaagag tttaaaaaca aaccttaatg
      181 atggtgttgc tgctcacttt ctgcttctag ctcttcgata tttcgcttgt gagcttggtg
      241 ggttgccaag tcttcatcaa cttcgatggt gacattttga aagccactct ctttgagcaa
      301 gtctcggata gactctttac agacctcgat atgtttgaca tgctccagac aaacatggac
      361 aatagcattt ttctccaagc cgtccatggt ccaaagatta agctgattga tactagcaac
      421 attatccaac tgctctaagt cattcttaac ttgcttgata tctacccctt ctggcacagc
      481 atccaggaaa atcttgagcg tgctccaaaa acgtggaatg gctttggaca gaataaagaa
      541 ggaaatagca agagacaaga ggggatctag gatataccag tccgtaaatc ggaggacaat
      601 ggccatcagg atgacagcca accaacctaa ggtatcttcc aaaaaatgca ggctgagaat
      661 agactcattc ttggtctgac ccttacgaat gaccagacta gccagcagat tgacactgat
      721 agcaataatt cccaaccaaa gaagcccttc gtcattgacg ggttgtgggt ggaaaagctt
      781 gcttatattt tctaaaatca ccataccaga ccctgtcatc agaatgactg ccgttaccaa
      841 agcccctaat aagctaaaac gcttgtagcc tagggtatag cgactatctt cttcacgatt
      901 ggagattgtt tctagaaagg ccgagaggcc aatggctaga gcatccccca agtcatggac
      961 agagtcagcg agaacagcac tggaaacaaa gattccccct gcaataaact caacaatgga
     1021 aaagcttaga ttcaagaaaa aagccaacca gactgcatat tttgaactca ttttttacct
     1081 tcctttggta taatagattc acgaacatca tattcaatat ctattatcca atactaccaa
     1141 cagaaaggat aggggcaaac cgttcgctgt gtacgttact gaacagtttg ttcatagtgt
     1201 ccatatgact gcacaagatc gtcgcattac caagactaga aaagccatct atcaagcttt
     1261 cttgtactta cttaaccaaa aagattatga ggccatcacc gttcaggaga ttattgactt
     1321 ggctgatgtg gggcgttcga ccttttacag ccattatgag agcaaagagt tactactgga
     1381 tgagctctgc caaaagctct ttcaccattt gtttgagcgt actcaatacc tctctccaca
     1441 agactacctg gcccatatct ttcaacattt caagaaaaat caagaccatg taaccagtct
     1501 cttgctttca aaaaacgatt attttatccg gcagctgcga aaagaactgg aacatgacgt
     1561 ctatccaatg gtagctgatg aactgattca atcacacccc aacattcctc actcatatct
     1621 caagcacctg gttataacca acttcattga aaccctgacc tggtggttga aaaaaggcaa
     1681 gtcctacagc gagcaggaag tagtccagtt ttatttggag attttaaacg tcgcttctaa
     1741 ctaaggtgcg actttacatc atgtatcata gaaaggaaaa ctatgctcct tctcattctt
     1801 cttggtattt tcacagcttt cttatccctt gcttttgctc ttcttcattt aatggccagt
     1861 ctttcagaat taagaaagca caagaatact ctaggaaatc ggcttctcct tatcggaagc
     1921 aaccttgcga ccttctctca tcctttactt ccttttgccg attgttgctt tattcctttg
     1981 gctgatcgga gttagcttga tttgctacgg agcctattgg aatggcaagc ataaaggaaa
     2041 tttccatcta gtagcccact acctgattcg gatcggaatc gctctggtaa ttacgatttt
     2101 attaactctt gtataagaaa agatcaagtt ttattaatga aaacttgagc ttttttctta
     2161 tatttatgat attaaacatt ctgcttttct ttaaacattt tgaccttttc ttggcagtaa
     2221 ttcattaatt tctgtgtttt ttcaaatgag tagccttttt cagataccga cttgactttc
     2281 ttttcatcaa agtagtagcc agtcaagcca ctgacttcct ctgataaggt gagataatag
     2341 cctgtttcga ttccctgatc tagatctttt gaaagagact tcatcaagcg tccgaagaga
     2401 gacttttccg tctttttatc actagaatta ttccctaagt tggttaaaat caagccgaga
     2461 tggtaggcat taatagtggt atttgaacct tttaaaaaga aatctcttgc tagatagcgt
     2521 gtcatccaaa tggtgtagag cttggaatta ttgtaggcca aaccgggatt gtattctttc
     2581 tcaaagccaa agtccaaatc cttcactttc gcaaaatggt gcatatagga agaggtattg
     2641 ataacaaggc catcaggcaa tttttctaac aaggggatta gctctgttat aaaaatatag
     2701 ggaaccagaa cggataacat gaaagttagt tcgacatttt caccactcgc ttttcgctct
     2761 ttccctgcat acagacctgc attgttaaat aagatatcaa tcctttgaaa gtctcgcttg
     2821 atttcctcca caaatcgata aacattatct aattttgaaa aatcagccaa gtagctagac
     2881 actctgcctc tcaaggagac tgcccgaacc tcctgagtag ccaattccag cttttgagga
     2941 ttgcgaccgt ggaggatgat atgatagcct tcactagacg gtttctttgc tagatgctta
     3001 ccgataacgt ccgtagcacc tgttagatgt aggaagtaat aacgatcgtc aagatatcac
     3061 aacacttgtt gtcaatgata aagatcaaaa aacacttcaa aattacatca aactcaatca
     3121 tcgtgaaact ggtcagaagc ttgatttgac tgaaaaaggc attattatct cagagaaatt
     3181 ggcggaccta gctggtattt ctgtaggtga tgaagtaacc gttcaaaata gccaggacaa
     3241 agacatcaaa ctcaaagttg ctggtatttc tgagatgtac atggggtact tcatctttat
     3301 gaacgaatct acttataagg atgctttcgg aaaagaggct agccaaaatg ctacgatact
     3361 tacactgaaa gatcattcag acaaaaatgt tgagcaaaca gccagtcgat ttatgtctct
     3421 tgatggtgta aaaggggatg tccaaaatac tactctaaag gcacaaatca agaccatcgt
     3481 caactcactt agccgtgtta tgggagtttt gattagtgtt tctattcttc ttgcttttgt
     3541 tgttctcttc aatttaacga atatcaatgt ggcagagcgt atccgcgaat tatcaaccat
     3601 taaggttcta ggtttcttta ataaagaagt gacgctctac atctatcgag aaacaatttg
     3661 tctttctatc attggtatct tggttgaatt cggacttggt ttgggactgc atcaatacat
     3721 ggtagatgtt atcccacctg aaaatattat gttcaatcca aatcttggct ggctcatcta
     3781 cgctgttcca acactagtaa tcattatcat tctgacaggt tctgggtatc tttgtgaacc
     3841 aacaccttaa gaaagtcaat atgctcgagg ctctaaaatc tgttgagtga gatatgctat
     3901 aacttaataa ataaaacgga agagttagga ccacttcgtc gttttaaaac aagatactcc
     3961 cctatgtcga ataggggagt atcttggctc tataatttct gtagtgggta aaactactgt
     4021 agggattata gagctttttg agtgtacaca aaaagtccca taagaactat aatgaaaagc
     4081 aaccaaacca tcattaggaa gaatttatga gacttattaa gaataacaca gaattaatcg
     4141 gaatcaaaga ccaaaatatc aagatttcac ttgtttttga aactgacact catatcgaga
     4201 ttcaagcaaa acttgattac cctgcaccat catgtcctca ttgccatgga aagatgatca
     4261 agtacgactt tcaaaagcct tctaaaatcc ctcttctcga gcaagcggga acgccaactc
     4321 tactacgtct gaaaaaacat cgtttccagt gtaaaagttg tagaagagtc acggtagctg
     4381 agacatctat cgttgagaaa aactgccaaa tctccaatct agtccgacaa aaagttacac
     4441 aactcctaac tgagaaagtg tcactaactg atattgcaag cagacttcgc gtgtcgacgt
     4501 ccactgtcta tcgtaagctt gatcagttta ctttcaagaa acattatgac aaactccctg
     4561 ctgttatgtc ctgggatgag tttgggttca agaaagggga attggctttt gtggcgcaga
     4621 attatgagac aaaccaactc ataaccatcc ttgataatcg ccgccaaact actatacgaa
     4681 actacttttt gaagtatcca ttgaaagtcc gacaacaggt acagtttatc acgatggata
     4741 tgtctggagc ttatattcca ctggctcgca agctctttcc aaacgcaaaa atcgttcttg
     4801 atcgtttcca catcatccat caccttggac gtgccttttt aaagacaaga attgcaatta
     4861 tgaaccaatt cgataagaag tcactaccct atcgagccct gaaaaatcac tggcgactct
     4921 tccaaaagga cagccgtaaa cttatctctc aactcttttt attcaaagac tttccgccaa
     4981 actttagcac cacatgaagt tgttgcgaag acactagtct tttcaaaaga gtttactgac
     5041 tactatacac tttatcagct tttgcttttt cactttcagg agaagagagt agatgagttc
     5101 tttgaactga tagaggaaaa taggagcaag gtcaatcatt attttcaaac tgtctttagt
     5161 acttttctta gacacaagca aatacatcaa aaacacacta gaaacggact attcaaacgc
     5221 gaaacttgaa gcgactaata gtttgatcaa agacatcaaa cgcttgggct tcggttttag
     5281 aaacttcatc aactttaaga agcgtgtctt catcactctg aacattcata aaaagaggac
     5341 ctatccggcc ctctctagat attagctttt cgtcacccac tatagttgac aaagagacag
     5401 tatcttattt atatgcttat tcagccttag taatatcttt acgcatttca tcaacattga
     5461 atttagcaaa gagatattga cggtcttgaa ctgggaagcg ttgatcgagt tggtcaactg
     5521 gtccaacttc aataatacca ttctcgataa caaagtctat aacgtgacca ccgaatgtca
     5581 agtcatctga aataaaatgg agatggtaac cagcaacact cacaccgtgg aacatttcag
     5641 gtgtccagat accaacgatt gtacctgaaa tatcatctac ctcatactca ggttggcgag
     5701 tggcaacatc agcaaactta atgtccgcat ttgattttgg aatcatgcgc acgtgcatgt
     5761 gtttaaaatg acctttgatt ttgattgaac ggaaaagatt gaccccatca tagtatgatt
     5821 caatacgatc ctcaagttct ttatcagtca tttcataacg ttgacggaag ataacttcag
     5881 cttggtgagg tacgactgct gcatagggaa ctttttcatc aggagaaact tctaccactt
     5941 cgactttacc ttcagagcct ttagcttggt aggctttacc gtcaagaaca atcaactcac
     6001 catcgataga atctaatgtt ccgagaccca agtctccatg ctctaacaac tctccaacgg
     6061 ttaaagtacc tccataaagc ccagccatca aggctcccaa agtattatat tgaaataatt
     6121 ttatggcttc agacatgtct acaccctctt tttagtaaaa ttcatctggc aaaatagttt
     6181 cgccgagttt aatgttatct ttatagtcaa ttggaacatc aataaggact ggtccatcta
     6241 cagcctgagt caaagcctct tgaagcaagc tagcaaatgc tgctttactt gttgcacgat
     6301 aacctttggc tccaaagctc tcagcatatt ttacaaaatc tacaggacca aagtcaaccc
     6361 cagatgaacg accgtacttc atttcttcct ggaattccac catattgtaa tgaccatcgt
     6421 tccagataat atggacaatt ggcaatttca aacgaactgc tgtttccaat tcttgtgctg
     6481 agaagaggaa accaccatca ccagaaacag aaatcacttt tgtcttagga cgaaccaaag
     6541 ctgcagagat agcccatgga agagcaacac ctagcgtttg catcccattt gagaaaagca
     6601 aatgacgtgg ttcatacgat ttgaaataac gtgccatcca aatatagtga ctaccaacat
     6661 caaccgtaac agtcatatca tcatctgttt gttcttgcaa aacttcgatt aaatctagcg
     6721 gatgcaccgt accttcatca ggctgacggt caaacttaac atcctcaaca acattgtttt
     6781 tcaaaccttt aagatattca accgaacctt caggcaattt ataaccttga atagcgggca
     6841 aaagcaagtt taagctcgct tctacattac caatcaattc acgttccggt tggaagtaag
     6901 tgtccacctc ggccggctca acatcaataa cgatgatacg tgctgaaatt tcagcattcc
     6961 agttacgtgc ttcatattcg attgggtcat aaccaatggc aataactaag tcggattttt
     7021 taagcaacat gtctccgggt tggttacgga aaagacctac acgaccaaag aaagtatctt
     7081 cttcaaggtc acgtgacacg ataccggcac cttggaaagt ttcaacaact ggcaatttaa
     7141 catgcttcaa aatttggcga atagagtaag ttacggcttc tgatgaggca ccattcccca
     7201 aaagaaagac tggcaacact gcatttttaa tggcttgtgc gagatagtta atatcagaaa
     7261 cagatgctga accaagtttt ggatctgtca taggcttaat agccttaaca ctgaccggag
     7321 catccgtcac gtcttgagga attgaaatga agcttgcacc tggtttccct gacttagcgt
     7381 gacgataggc attagcaacc gtttcagaaa gggtgttagc atcatgtact tcagcagcat
     7441 atttggtaat tggctcaagc atagcaacgt tattcattga ttggtgggca cgtttcaaga
     7501 gatctgcacg cttaacctga ccaccaatag caagaacagg gtctccttca tccgtcgctg
     7561 ttaccaaacc agtagccaaa ttggagacac ctggaccaga tgttaccaat actacacctg
     7621 gtttcccagt aatacgtcca acaccttgag ccataaaagc agcattttgc tcatgacggg
     7681 caacaatcaa ttcaggtccc ttatcttcca aggtatcaaa aaccctatcg atttttgcgc
     7741 ctggaatccc aaagacatac tcaacatcat ggttgatcaa actatcaacc actaaatctg
     7801 caccatacaa ttgcttttct tctgacatga acacagtcct tctagcccta aaatggtaga
     7861 gccaactttc ctttcaagta taagtcacaa agtgtcaaag tctgctcgtt ttttcacaaa
     7921 ctttcatcaa ttcacaattc tgttatcatt atagcacagt tttcagacaa tcttgtgaaa
     7981 aaaggcagac taggtgacta aaaaaagaca aacactcaaa atagcgtttg tctactttat
     8041 agattaacta tctcatttgc ttgttttctg atttataaat attacttatc aatgcttagt
     8101 tttttgaggt ttacaaacac acaataacac agaagaataa acagagcaaa aacagcaaga
     8161 cttctgaaaa ctaaaacaag atgactactt aaaaaggcaa aacttcctat tactaaaaca
     8221 gcaatgcctg aaaatacaga atgtaaggtc tccgagtaaa tatatagttt ctgtaattct
     8281 ttcatgttaa gtgacaactg aaaataattg gtttcgatta tccccatcat tgtctgacct
     8341 atcgctagaa aaacataact cattagtact gtataaatgt tcgaagatgt actaaataaa
     8401 agtagatata gaacataaaa tgaaagacct aaggcgaaag ctttcatatg agaacttatt
     8461 tgtttcacga agctaagaag gaagctcatt actaagaatg aaactgctaa aaatgataag
     8521 gaaaaggaat acatagaatc actaataccg agatactttg ttaaataaac aacttcataa
     8581 gtatcataaa caactccaat tgatcccaca ataactccag ataatagaac taatgcaatt
     8641 tttttggatc tcagaatgtt aaataatgta atgtttaaat tttgtttttt tctttcttct
     8701 ttcaaattta aagtcgaaat atttggtaaa aataaaagac tagtagctcc cactatcaaa
     8761 agaagagcat aaactgcaaa caataaaaag tgacttttat taataaataa accaacaaac
     8821 aacggtgcta aaaaataaga tactgaacca atgcttgtat acctagcgtt aaacttaatc
     8881 aatgaatcct tgtctataat aattggtaca caactatata ataaactgga aaacaataca
     8941 ttgacaacct caattatgaa tacaactaat aggacaatta tatggtttaa tccaaaacct
     9001 agtaagaaaa gtaagattgc ctttgtaatt tctaacagaa taagcaggta ttttctgctc
     9061 agtttactat ttgagatatt aatcctattt gtaactattg cagctaaaca ctttaccacc
     9121 caaaaataca taactaattg cacagaaatt ctagacaata gaatgttgat caagatagta
     9181 taaccatact ctgagattaa cgatgagaaa cgattaaaat aaatactcaa tgctgcatat
     9241 ttttttattt tcaatatttc ctatatcctc cttaattttg atttaacaaa ttgaatcatt
     9301 tggtaaaaaa tgtgagcatt atcacttcca accatcggat tgcactcaac tatatcacaa
     9361 aaatatacct tatcagaaca taaaattttg gaaattattc caagaaaatc gttcatttga
     9421 aatcctccaa taataggata tgatactgaa tcaaaaacag atggatccaa aacatcaatg
     9481 tctattgata agtaaatatc ttttgactca tcaatataac tatctaactt tttcaaaact
     9541 ctactcttat ttaaccaata ctcctccatt gagaggatga ttattttatt atcaaatgaa
     9601 ctaggaaact caaaattcct ttccccaatg ataattattt tttcaaaaat atcggttaaa
     9661 aaacttaaaa aattccaatt ttttacaaca ctttcaaagt ctttgaagta atctaaatga
     9721 gcatctaaaa caattaaata tgctccctct cgaacagtgg cctttgctaa tagataagta
     9781 actgaatgat ctcctcctaa agcaatctga actttagatt cagcaatagt tcgacttaga
     9841 ctttctaaat caatagaaaa taaatcttga ttacctaaat taattgtaat tatatcagaa
     9901 tctttcctat catataacat cgcttcttga taatattttg tgggagcaaa tctcgctcct
     9961 ggaattctac ttccaccatc ataaataata gataatattt tcataaactc attgactttg
    10021 gcttaatccc agttaaatta tatgctaact tgcactcctg tatatcggga ctcccaatag
    10081 aacctccgaa aaactgagct cgacttctac acccaccttg acaaacataa tttgcagggc
    10141 attcattata atacttacat cgtacatttc gaatatgatt gaagaacttc gaattaatcc
    10201 aaatatcatt taaagtcttt tcattaatgt tacctccgca aaatttagtg gaggataatg
    10261 tcggacaaaa tccaacatca cctgacgaat ttataaacac ataagaattg ccagcaccac
    10321 aataaaatga ttcaaatgtg gattcggata tattattaca atttgcttga atattgggaa
    10381 tacacaaaat agcattattg aattcttcat cactaattga tagtcgatta ttcctttcaa
    10441 aaggtaaaaa cctatcaaaa gcatatttca catctaatcg atcaaacaac tccaaaaaat
    10501 acttcactcc actaatattc ttgttattca aaacaacatt aacagtaaca ggtactccta
    10561 aactcctaaa atattcaata ttcttaattg ttctcttaaa tgtacctctt cctctaattg
    10621 aatcatgtat tgtttcattc caaccatcta aactaacttt tagtcttata ccatcatatc
    10681 tttgaatcaa tattttaaaa tcttcaggaa tatatacagc atttgtaaaa attgttgtac
    10741 acattccctc ttttaatact tcctcgataa tttcacttaa tccctgtaat aataatggtt
    10801 cgcctccagt gaaatcaaca tccattactc ctagctgctt agcttcatat actatacttg
    10861 aaattttctt tctatcgagc tcctttgaat aatcaggtaa ataacaatgc atacatctta
    10921 ggttacattt gttcgtgacc tcaatctgta tcacttttaa tggtattttc gttgaaaatt
    10981 caacaatttt agtgttggtc ttagagagtg atatttcatt gttatttaga aaatctataa
    11041 cattttttat tacctgactc tttgaatcag aaaacttttt caatgaaaat tggtacataa
    11101 attttaaagc taaaaatgta gctaaattta atgaaaatag tttattattc ctattattcc
    11161 tgagtattcc ttgcttattg taccaattaa aaaaaatcga gtaaacattg ctcgtcatat
    11221 taattccctg caatcttcca aaaatattaa tataaaaacc aaaggattag aaatagactc
    11281 taatcctaca atcagttcta ttagacagac ggtgggcaac gacctttgag tccatcaatc
    11341 aactctgtag caacagaagg tttaatttcc ataatgtcaa tagatagacc gctagaaaca
    11401 acttcttctt ctgctaattc aatttgtgca atagcatcac taacttgcat cgtaatatcc
    11461 tccattattt atttaagaat caataagtac ccataacaaa tcatagaaat cattctttat
    11521 ctataaaatt tagctgaaaa tgctttgaaa ttgtcttatt aaactgattt gcaggtagtg
    11581 taaaataagt tgtgtaaaca caaaaaggaa taaatccgtt atagtagagt tgcaaaacat
    11641 tactagaaag agatttattc ctatgactcc gtttaccaca gaa
//
