LOCUS       gnlProkkaPCEOLIPN_1    12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PCEOLIPN_1.
ACCESSION   gnlProkkaPCEOLIPN_1
VERSION     gnlProkkaPCEOLIPN_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:33:11
            Original ID  :: gnl|Prokka|PCEOLIPN_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 628184
            Orig. end    :: 640326
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             637..2187
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 384.8; E-value: 5.8e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_595"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKANIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTDEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
     CDS             2550..3812
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 68.5; E-value: 9.5e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_596"
                     /sec_met_domain="ATP-grasp_3 (E-value: 5.1e-12, bitscore:
                     44.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2e-07, bitscore: 28.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.2e-06,
                     bitscore: 25.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQFLNCAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAQN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             3775..4986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_597"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.8e-15, bitscore:
                     54.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3.1e-05, bitscore: 21.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 5e-10, bitscore:
                     37.0, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 3.2e-08, bitscore:
                     31.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVARAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEAYFKECSKHDEEKSVLAEEFIEGQEISIEAVVCQGKADIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMNCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             5001..5885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.8;
                     E-value: 1.5e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_598"
                     /sec_met_domain="phosphonates (E-value: 5.1e-108, bitscore:
                     358.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 3.1e-126,
                     bitscore: 417.8, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.1e-67, bitscore:
                     225.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALNSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             5943..7142
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value:
                     1.9e-69. Score: 226.3. Matches aSDomain:
                     nrpspksdomains_ctg1_599_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 287.8; E-value:
                     2.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_599"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-67, bitscore:
                     226.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-09, bitscore:
                     36.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTKIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYSEIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCAKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPNNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        6039..7106
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_599_Aminotran_1_2.1"
                     /evalue="1.90E-69"
                     /label="ctg1_599_Aminotran_1_2.1"
                     /locus_tag="ctg1_599"
                     /protein_end="388"
                     /protein_start="32"
                     /score="226.3"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYSEIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CAKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPNNIRL
                     NFAIPKDLITEALKRI"
     CDS             7207..8439
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 254.7; E-value: 1.8e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_600"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLVFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSSNPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGH
                     SKVDVTESHRS"
     CDS             8758..9291
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 106.3;
                     E-value: 2.4e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_601"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQDTLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLKEPKYFKTWLIRILLHTIFAMRKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             9273..10715
                     /locus_tag="ctg1_602"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKL
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEESISFQVDYKDPWNMLAEDYDNSD
                     MKKMKDGRYAGQLRLFTDGSKLKDGDKLPLVITKIKDIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSIDFHDAAKNDAISIYEATDDAGNHYEMTAS
                     NIELGGRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHQHVGITIKKIKQQGRRVIVDYQFTGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSTDKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRPADGK"
ORIGIN
        1 gggaactcgg atgcaccgtc tgacaagcag cgtcaggaat caaagccgga aaaagaggaa
       61 aagccgaaaa agcgggatca cagcgcggca ccgcagcctg tgatccgcaa caaaaccgcg
      121 gcacagctat ggccgtatgc agccatcgtc attgtgattt cagccgcggc ggcactcgcc
      181 tggctgctcc gggcgcgctg gattccgcac gttacagcag ccagattgaa gcggcgaacg
      241 gatgaagacg tctttttcga cgcatatgcc gcgctgctcc gccagctgaa acgaaaaggg
      301 ttcagcagga gagacggaga aacgctccgt gattttgccg cgagggttga cgaggcgcac
      361 catacaaacg acatgtccga gctgacgctg cgctatgagc gtgcattata ccgcagcgat
      421 aatgccgcaa agctttggaa tgaatcggga cagttgtggg aaaatataat taaaagaaga
      481 tagtcttgac cgcatatcgt cctgttgtta gaataaatga atgttaaatg ggagcccggg
      541 agcgttaaaa agccgggctt ccggacaagt cttgccgaca gagggctgaa cgtgtgtcct
      601 ccgttttttc tgtgtcaaaa acttagagga gattaggtga caaccatgac gaagttagtg
      661 aatgaaatga ttcttgttct tgatttcggc agtcagtata accagctgat tacccgccgg
      721 atccgtgaat ttggcgtata tagcgagctg catccccata cgttgacagc tgaggaaatc
      781 aaagaaatga atccaaaagg aattatcctt tcaggcggac caaacagtgt atatgatgaa
      841 gggtctttcc gctgtgatga aaaaatcttt gaacttgata ttcctgtatt gggcatctgc
      901 tacggcatgc agctgatgac tcattacctc ggagggaaag tcgaggcggc aagccagcgc
      961 gaatacggaa aagcgaacat tcagattcaa ggaactcctg acttgttcaa agatcttccg
     1021 gaagaacaag ttgtctggat gagccacggc gacttagtcg tacaagtgcc ggaagggttt
     1081 acggtagacg cgacaagcca tcactgcccg aactcggcga tgagcaaaaa agacaaaaaa
     1141 tggtacggtg ttcagttcca tccggaagtc cgtcattcag aatacggaaa tgaccttctg
     1201 aaaaactttg tcttcgggcc ttgtgaatgt aaaggcgaat ggtcaatgga aaactttatc
     1261 gaaatcgaaa tgcaaaaaat ccgcgaaaca gtcggagaca aacaagtgct ttgcgctttg
     1321 agcggcggag tcgattcttc tgtcgtagcc gttttgattc ataaagcgat cggcgaccag
     1381 ctgacttgta ttttcgtaga tcacggcctt ctccgcaaag gcgaagcgga aggcgtcatg
     1441 aaaacgttca gcgaaggctt taatatgaat gtcattaaag ttgatgcgaa agacagattc
     1501 ttaaacaagc tgaaaggtgt ttctgatcct gagcaaaaac gcaaaatcat cggcaacgaa
     1561 ttcatttacg tgtttgatga tgaagcggac aagctcaaag gaatcgacta ccttgcgcaa
     1621 ggaacgcttt acacagacat tattgaaagc ggaacggcaa ctgcgcaaac gatcaaatcg
     1681 caccacaatg tcggcggact tcctgaagat atgcagtttg aactgatcga accgctgaac
     1741 acccttttca aagatgaagt gcgcgcgctc ggcacagagc tcggcatccc ggatgatatc
     1801 gtatggcgtc agccgttccc gggccctgga cttggcatcc gcgtactcgg cgaagtaacg
     1861 gacgaaaaac ttgagatcgt tcgtgaatca gacgcgattc tgcgtgaaga agtggcgaac
     1921 cacggccttg agcgcgacat ctggcagtac ttcacggttc ttcctgacat ccgcagcgtc
     1981 ggcgtcatgg gagatgcgag aacgtatgat tacacaatcg gtatccgtgc cgtaacatca
     2041 atcgacggca tgacatctga ctgggcgcgt atcccttggg atgtgcttga agtgatttcg
     2101 acacggatcg tcaatgaagt gaaacacatc aaccgcgtcg tgtatgacat tacgagcaag
     2161 ccgcctgcaa cgattgagtg ggaataatga gaaaagcctc aaatctttta tttataaaga
     2221 tttgaggctt ttttaattta catggttcta ggaataatgg gccttttatc attaacaccg
     2281 gagaagatgt gcagcagttt tttatatatt cgagtttttt aatcagttgt attcctaata
     2341 ttctccctat aatttcattt tttctaataa aactgaattc ataaaatatt catttaataa
     2401 caaataatgt atgttattat gaatatatac aaataaaaca tatgatggtt tgtgttttcc
     2461 aaggggtttt ttatcttctg cattcagttc tttagaaacg cagaaggttt ctaatttgca
     2521 gaaaaaaatg ttgaaagagg ctcggaagga tggaaaaaca tattttattt tttaatgcta
     2581 cttatattaa aaaaatttct actttggaga ctgctaaaaa tttgggcttg acggtttctg
     2641 ttgtcggacc tgaactgcct gaatggtcgc ggccattcgt tgaccattac atttccgcaa
     2701 atacttatca gattgatgag actatagctg ttctgaagga aactgccaaa gaaaatcctt
     2761 ttgatggagt cattacattc tgggatagag atgtggttcc ggtggcggta actgcccgag
     2821 aacttaactt aaagggcagt ccggtggaag cggcagaacg ggctcgaaat aaatggaaga
     2881 tgcgtcaatt tttgaactgc gcacaagttc ctcatccaaa atattgcaaa tttacaaatt
     2941 ggaccgaatt atatcatgca agcattgata tggaataccc attgatcgtt aaacctgtgg
     3001 gtgcttctgc cagtaaaggc gtattccgaa tatcaaagcc tgaagattta aatcgcgcat
     3061 atcagcagct gttaaacgct gcggtgccgg aaaacgataa aatgttttct ttttatcaaa
     3121 acgagtatat tgttgaagag tttatgaacg gacaagaagt cagcattgag ggagtgattt
     3181 ccgacggagt cattcacttt gcaggtgtta ctgaaaaatg gacggatcag tatttcgaag
     3241 aataccagca tgcatttccc gccaggctgc cggaggctgt ggaacgtgaa ttattccaca
     3301 tcaccagtga agggataaaa gctttggagc tgaacaattg tggttttcat gccgaggtca
     3361 tgatcacaga gaaagggtgc aagattatcg agatcaacgg tcgtctgggc ggcgatttta
     3421 ttactaccca tttggttcct ctagccaaag gtataaatat aacgcgcgca aacctattgg
     3481 ctgtattagg agaaacaata agctttgaag cttcgaaaag aagagctgcc tgcgtcaggt
     3541 ttttaattgc agaccgtgct ggtgtgatag aaaagtggga aggtgtcgaa tcgatcaaag
     3601 aaatgcccgg ggtcgttgaa tttgttttag aaaagcagcc gggcgatcat gttggcctgc
     3661 cgcctgaaaa gtttcatgat tcccggattg cttatgtcat cacagaagcc gaagatacag
     3721 aaaaagcgat cgaatatgct caaaatgctt tatctgaagt gaggtgtttc atcaatggag
     3781 aggaaaagac tgttcctgat cgggattcct gaaacgcata ttgagaaggc cgttgcgagg
     3841 gcaaaacaac ttggttttga cgtcttatta ggagatacag aagcttcatt aaaaaaatat
     3901 gagcatttaa taaaggaagc tgaccaaaaa atcgcattag attataccaa tcatgagaat
     3961 ctattctcag tcgctaaaga aatccatgac aaagagcctt tagatgccat atttactttc
     4021 aaagaagccg gcttattcaa tgtatccaaa cttcagcagg catttcattt aaaaggaaat
     4081 cctccgtctg tggtgcaagc atgccttgat aaatatacaa cgcgccggct tttaaaaaag
     4141 gcaggactaa actctcccga ttttggattg tgcaggagcg tggaagacgt atacgatttt
     4201 tggaatacat ctcaacatcc tatcatttta aagccgagat ctcagcaagg cagtataggc
     4261 gtcataaaag ttgagaaaaa agaggacatt gaggcgtatt ttaaagagtg ttcaaaacat
     4321 gacgaggaga agtcggtatt agccgaagaa tttatagaag ggcaggaaat ttcaatagaa
     4381 gccgttgtct gccaaggcaa ggccgacata tttggtgtga ccgaaaagct gctatacccc
     4441 gggacttttg tagaatccgg gcatatatcg ccgtataaac ataaagaaaa acatcaggat
     4501 ttgtataaga atctggtcaa ggaagttgtt catgccatgg ggatcgtatt tgggcccttg
     4561 catattgaag ggtatcacac aaataaagga tttgtggttg gcgaggtaca cacccgctat
     4621 ggcggagaca acatagtgac cattacagaa atcgccatga attgtgatat gcatacacct
     4681 atttttgcgg aactggcggg catcccatat caaccggaaa ggaaacatgc tcaaagcgaa
     4741 gtatgcgccg ttcgtttttt agaaacgaac caaggggttg tacgcgcaat caaagggatc
     4801 agcgatctca aaatgatggg gaatgtagta gattttcatg taaattgcag tgtcggtgat
     4861 agaatcagac cgatcaaaaa cagctacgat agagcaggat ggatgattgt aaaggggaaa
     4921 aatgagcgag aagtcaatca cgcattacat gatgcgattg acaaaataaa aataatcatt
     4981 aggtgaaggg gagaatgatg gtgaaaaaca gaaaatcatc aatttttaga gatgctttaa
     5041 acagtaaagg tttggtgaaa gttgcgggag ctcatgacgg tttaagcgcc aaattagcag
     5101 agaaaaacgg atttaatgcc gtatgggcaa gcggtttggg aatctcggct gtgcaaactg
     5161 tacctgatgc cagtatatta acgatgactg aatttcttga agccgccgtc attatgaatg
     5221 aatcatgcaa tttgccggtc atcgctgact gtgattccgg ctacgggaac attcacaatg
     5281 tcacccgcat gatcaaaaaa tacgaagctg ctggtattgc cggagtttgt attgaagata
     5341 aagtatatcc aaaattaaac tcatttgacg acagacaaca gatccttgtc agtactgaag
     5401 aattttgcgc aaaaattaga gccgcaaaga tggctcagca aaatgacgat tttgtattga
     5461 ttgcccgtgt cgaagcttta attgctaaat tgggtcaaga agaagcctat acaagagcaa
     5521 aagcttatgt tcatgctgga gcagatgcaa ttttaattca ttcaaaagaa caatcgcctg
     5581 atgaaattat tgagtttgtt aacaattggg acgtggatgc gccgttggtt gtggttccga
     5641 ctaaatatcc gacgctctca atggaacagc ttgagaaatt gggagtgaag gtttccatct
     5701 atgcgaatca ggcgttgcgc gcttctgtta aggctataaa tgatacattc gaaagcatta
     5761 taaataataa atcgtctttg cagattgaaa atgacatcgt gagcgttaat gagatatttg
     5821 acattcaaga cgttccgggg atgaagcaac tggagcgttt gatccataga cagccggcta
     5881 actgaggttt ttgtatcgtg ctattttaag aatggcccat aaagacattg gaggcgtttg
     5941 aattgaataa aagattatcc gatagagtca tgaatataaa accttcggcc actatgtcat
     6001 taaatgccaa aacgaagata atggtaaaag aaggaaaaga cattataaat atgagtgtcg
     6061 gagaaccgga tcttcatccg ccattaacag cctcatatgc aggaattcag gcaatagtga
     6121 aggggaaaac cgggtatacg ccggcagcag ggctgattga attaagagaa tccattgtgc
     6181 gatatctgct taacgaacga ggtttagaat ataaaccaaa ccaaataatt gcatctgccg
     6241 ggggaaaaca gccgctatat aatgtttttc aagcaatttg tgatcaagac gacgaagtta
     6301 tcctcccttc accttactgg gtatcttatc cggaacaaat caaactgtcg ggggcggttc
     6361 ctgttattgt aagctgtgat gaaactacaa attttaaaat cacacccgag aagcttgcag
     6421 aagtaattac ccctaagaca aaagctgttg ttatcacatc tcccaataat ccgacagggt
     6481 ccgtttattc agaaaatgaa ctgaaagctt taggaaatgt gttgaaagat tattctgaaa
     6541 tttttatcat ttccgacgaa atttatgatc agtttgtgta tgagggcaag catatcagtc
     6601 tgccgctcat ttttcccgaa ttgctgaatc ggaccatcat aacgaatgga ttttccaaag
     6661 tctttgcaat gactggatgg aggctcggct atatcgcagc cccatcggat atagccgaag
     6721 ccattgccag ctttcaaagc catgctacag gcagcccgtc aactatttct caatatgccg
     6781 gtatttctgc tttaaacggt tttgacaagt cgatggtcga agaatacaaa aaaagacgcg
     6841 atatattagt cgatggttta aatcaaattg agggcattca atgcgccaaa ccaaatggag
     6901 ccttttatgc gtttccgaat gtttcacaat ttttcggaac aatgtttgaa gatcaacaaa
     6961 taattgatgc ggagacattt tgtcatcttc tgttggaaaa acagcacgtg tcagctgttc
     7021 ccggcacagc attcggagag ccgaacaaca ttcgtttgaa ttttgccatc ccaaaggatc
     7081 ttatcacaga ggctttgaaa agaattaata attttacaac tcagctggca gttaaggtat
     7141 aacagagcgc tgaaagctta aacgagcctc tttatatctg catctaatgt ttaggcaggt
     7201 ggttttttga aaggcatacg attaagaatt caccctgtgg gctggaatat cattttaggc
     7261 accttgttta gcagaatgtc agtctcgatg agcattccct tcctttctat ttacctaaca
     7321 caagtaaaag gtgtttctcc tgctttgacc ggcatcattg tttcagtaag ttcgctggct
     7381 gggattgtaa tgagctttta cggagggtat ttgtctgatc tttttggcag gaaaattgtg
     7441 atgataacgt ctgtattttg ttgggcgctt gtttttgtaa gttttatgtt tgcagatagt
     7501 gtactcgcat tttttgtcat caatgcgctt aacgggctgt gtcaatctat ctttgaaccg
     7561 gcgtcaagag cattattatc cgatataagc aaagaagaaa atcgtttgaa gatgtttaat
     7621 ttgcggtata ctgcgattaa tatcggcgta gttttcggtc ctcttttagg ccttagattg
     7681 ggagctgcca agacggctct cccatttctg ttcgcaggtt ttacatattt tctttatggt
     7741 ctatctctcg tattttcatt ccgaaaattt aaattagacg agaacaatcg aaaagaaaat
     7801 aaaacgacta ttgctacggc ttttaatgtg acaaggaaag acaaggtttt tcttatcaca
     7861 ttacttggag tgatattatc aatatccgga tatgcgcact tttctacaac attgccccaa
     7921 tattttgccg ccaaaataga ggacggggtg accatatttt catggctttt agctttgaat
     7981 gcaattgtcg tcttaattgt tcaataccct attgtgaata tcatgaaaaa gttcccgccg
     8041 attcattcaa tcattctggg aaatgcttta attagtttca gtttattatt tttttcgcta
     8101 tcgtccaacc cattcatatg gggctctatc gtcgtgtttt tcacaatagg ggaagttttg
     8161 attttttcga tggttgatat gctggtggat gaaattgcaa aaccaggctt caaagggaca
     8221 tactttggag cagcaggctt taaccgttta ggaaatgtaa tcggtccttg gctgggaggg
     8281 attcttcttt ccttttttgg tgtaaacggg tccttctata tgtttttgat catttttata
     8341 acgacagcct cgggaattcc ggttttattt ttggcaaaaa aacatcttga taagagcgga
     8401 cattcaaaag ttgatgtaac agaatctcat aggagttaaa tgttttaaca caatgaagaa
     8461 ttaatggcaa agtctttgaa cctcaaaggt ttaaaggctt ttttcttttc agcagcgccc
     8521 catcagaatg ggaaacaaga gtgtttatat ttttggggag aggaatacag actgaacggc
     8581 gaacaaagaa ggtattaatc taagggactg accccataag atgagacaaa taaaaaacac
     8641 cttcaagttt gaaaacggat cgttgttatc cgaaattaga ctttgaggcg tttttttttc
     8701 atctttttga aaccgttttg ccttgattca tatctaacag cataggaggt ggataaggtg
     8761 aaggaagaac gattgatcaa aaaggcgaaa aaaggtgatg ccgcagcctt tgaaaaactg
     8821 atcaccgcac accaggatac tttatataaa acagcttatc tctatttgca tcacaaggaa
     8881 gatacgctgg acgctgttca ggaaacggct tacaaggctt ttcttcatat cgcgcagctg
     8941 aaggagccga aatattttaa aacgtggctg atccggattt tgcttcatac gatttttgcg
     9001 atgaggaaaa agcacggaga cgtcatcccg tttgagccgc agcatgatac gcgcgcggag
     9061 aataagaaca ttgaagaata catagatctt cggaatgccc tggaaacgct tgacgaacat
     9121 atacagctga ccattcagct ttattatttt caagatttct cgattgctat gatcgctgaa
     9181 cagaccggta tggcggaagg cactgtaaaa acgcatctgc acagggcgag aaaagcattg
     9241 aagcaggagc tggaaaagga ggataaacat atatggaaaa gcatcaaatg aagcaattgt
     9301 atcaggacat tgacgtgccg aaagctgaat tgaaaaatgt gatacacagc gccgctgtcc
     9361 gtgccggaaa agaaggcgcc gtcagacgga gatggggaag aaaactgata aacggactcg
     9421 cggttgctgc tgctttgttt attctgtatt tgtcctcagg cttattcatg ccctccgtta
     9481 atacggctat gggaaacatt cctgttgccg gacaaattta cagtctgttt caggataagg
     9541 caggttctgc gctgtttaaa agcaatttgg tgacaaaact gaatgagaaa gcggaatcac
     9601 gcggaatcac ggtgacagtg aaaagtgtgt attacgacag cggacagctc gtttacaatt
     9661 ttaccgttga caatttgaaa tcagatgagg agagcatctc ttttcaagtt gattataaag
     9721 atccatggaa tatgttagca gaggattatg acaacagtga tatgaaaaaa atgaaagacg
     9781 gacggtacgc gggacagctt cgcctgttca cggacggctc aaagctgaaa gacggtgata
     9841 agcttccgct tgtcattaca aaaatcaagg acatcccggg aaactggcgc tttacactcc
     9901 cgatcaaaaa acaaaagtcc gtttctctgg aaggaacgaa agccgtgaat gtaaatcacg
     9961 gattataccg ctttttcgat atcagggcgg aaaacggaac gacgggatcg gctctcctgt
    10021 attctatcga cttccatgat gcagccaaaa atgatgccat ctcgatttac gaggcaacgg
    10081 atgatgccgg aaaccattat gaaatgacgg cgtcgaatat tgaacttggc ggcagaaaga
    10141 atcttcccgg cggcgggaaa agaatacgcg gccaaactca attcagcaaa ccgatagacc
    10201 cgaaagcgaa aacacttttc ataacgggcg atataaaaac agaatcagag ccgggagaaa
    10261 tcgtgcctct gaaaacaaaa ctgcccgtca gttataaaac gaaacatcaa catgtcggca
    10321 tcaccatcaa aaagatcaaa cagcaaggca gacgggtgat cgtcgattat caattcacag
    10381 gaattaatta cagcaaagcg gatgaagatc agctgatcaa tgtcggtgag tcaatcggtc
    10441 tcggcaatac gaaaaaaatg aaaacctggc catcgcttaa tgagtatgaa aaaggctatt
    10501 atctgaaagg gaataaggcg aaagtcacga accttaaaac gggtgaaatg gaatccgttt
    10561 ttgaattaga tgattcaacc gataaagact attcgttgcg cgatttctca ttcgattcat
    10621 acgctttgta cgtcaatcaa acggttatga acttgctggc ggatgataag gggatcacat
    10681 tcgcggtgcc ggttcggcct gcggacggaa aatgatgtct ggaaggcggc ttttgccgtc
    10741 ttccattttt ggtcaattaa cgaataaacc aaattttttt aacgggattg ttcgtttttt
    10801 ttattgagtt ttcaaaattg aattgataca atagactcag aaatcaaata tgcagatatc
    10861 gtataatggc ggggatatgg cccgcaagtt tctaccaagc taccgtaaat ggcttgacta
    10921 cggatcaatc tcaatcgttt gatataaata atccattctt atttattcag actgaacgta
    10981 tgtagtcaag cgtcccaaat gtatttgggg cgttttttat ttggcggata acgggcagaa
    11041 taaatgggag agaatgaagg aggcaattgg cttgaagcaa ttttttcagt ttgatgagct
    11101 ggggacaagc tatcgtaatg aaatcatcgg cggtttaacg acctttttgt caatggcgta
    11161 cattctgttc gtcaatccgc tgacattgtc tttaaacggt gtgaagggat ttccggaagc
    11221 attaaaaatt gatcagggcg cggtgttcac cgctacagcc ttggcgtctg cggccggctg
    11281 tattttaatg gggctcattg caaagtatcc gatcgcgatt gcgccgggta tgggattaaa
    11341 tgcgtttttt gctttctctg tcgtcctcgg catggggatt tcatggcagg ctgcgctttc
    11401 cggcgtcttg atttccggaa ttatcttcgt ggcgctttcg ctgacgggac tgcgggaaaa
    11461 aatcattaat gcgattccgc ctgagctgaa attggcggtc ggcgcgggta tcggtttgtt
    11521 tatcacattt gtcggtttgc agggttcggg cattattgaa gcgaactcat cgactctggt
    11581 gtctatcggc aatattcaca gcggccctgt gctgctgacg gttttcggtg ttattgtgac
    11641 ggtcattctg atggtgcttc gcgtaaacgg cggcgtattt atcggaatgc ttctgacggc
    11701 ggttgccggc atggtctgcg gactgattcc agttccgacg cacattgtcg gcagcgtgcc
    11761 gagtcttgcg ccgactttcg ggcaggcgtg gatgcacctt ccggatatct tctccgtaca
    11821 aatgctgatt gtcattttaa ctttcttgtt cgtcgggttt ttcgatacgg ccggaacgct
    11881 ggtggctgta gcgacacagg ccgggctgat gaaggaaaac aaacttccgc gtgcgggaag
    11941 agcgcttctg gcagattcga catcaatcgt tatcggagcc gtactcggta cgtctacaac
    12001 gacttcttat gttgaatcca gctcaggcgt tgcggcgggg gcgcgctccg gcttcgcggc
    12061 tgttgtcacg ggcattctct ttttgctggc gatgtttttc tcgccgcttc tgtcagtcgt
    12121 caccacgaat gtgacggctc cg
//
