LOCUS       gnlProkkaEHCCKLDA_1    12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EHCCKLDA_1.
ACCESSION   gnlProkkaEHCCKLDA_1
VERSION     gnlProkkaEHCCKLDA_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 05:46:22
            Original ID  :: gnl|Prokka|EHCCKLDA_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 690521
            Orig. end    :: 702663
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             637..2187
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 384.9; E-value: 5.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_686"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKANIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADRLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTEEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
     CDS             2550..3812
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 75.6; E-value: 6.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_687"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.9e-12, bitscore:
                     44.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.1e-07, bitscore:
                     29.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.8e-06,
                     bitscore: 25.4, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQCLNRAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAEN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             3775..4986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_688"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.4e-15, bitscore:
                     54.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.4e-05, bitscore: 22.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.1e-09,
                     bitscore: 35.9, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.5e-09, bitscore:
                     33.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVTRAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEACFKECSKHDEEKSVLAEEFIEGQEISIEAVVCQGKVDIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMKCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             5001..5885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.8;
                     E-value: 1.5e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_689"
                     /sec_met_domain="phosphonates (E-value: 5.1e-108, bitscore:
                     358.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 3.1e-126,
                     bitscore: 417.8, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.1e-67, bitscore:
                     225.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALNSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             5943..7142
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value:
                     3.5e-70. Score: 228.7. Matches aSDomain:
                     nrpspksdomains_ctg1_690_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 287.3; E-value:
                     3.1e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_690"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.7e-68, bitscore:
                     228.6, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-09, bitscore:
                     36.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTKIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYSKIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCTKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPKNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        6039..7106
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_690_Aminotran_1_2.1"
                     /evalue="3.50E-70"
                     /label="ctg1_690_Aminotran_1_2.1"
                     /locus_tag="ctg1_690"
                     /protein_end="388"
                     /protein_start="32"
                     /score="228.7"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYSKIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CTKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPKNIRL
                     NFAIPKDLITEALKRI"
     CDS             7207..8439
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 254.7; E-value: 1.8e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_691"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLVFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSANPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGR
                     LKVDVTESHRS"
     CDS             8757..9290
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 106.3;
                     E-value: 2.4e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_692"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQDTLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLKEPKYFKTWLIRILLHTIFAMRKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             9272..10714
                     /locus_tag="ctg1_693"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKV
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEESISFQVDYKDPWNMLAEDYDNSD
                     MKKMKDGRYAGQLRLFTDGSKLKDGDKLPLVITKIKDIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSVDFHDAAKNDAISIYEATDDAGNHYEMTAS
                     NIELGSRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHHHVGITIKKIKQQGRRVIVDYQFSGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSSNKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRPADGK"
ORIGIN
        1 gggaactcgg atgaaccgtc tgacaagcag cgtcaggaaa caaagccgga aaaagaggaa
       61 aagccgaaaa agcgggatca cagcgcggca ccgcagcctg tgatccgcaa caaaaccgcg
      121 gcacagctat ggccgtatgc agccatcgtc attgtgattt cagccgcggc ggcactcgcc
      181 tggctgctcc gggcgcgctg gattccgcac gttacagcag ccagattgaa gcggcgaacg
      241 gatgaaggcg tctttttcga cgcatatgcc gcactgctcc gacagctgaa acgaaaaggg
      301 ttcagcaggg gagacggaga aacgctccgt gattttgccg cgagggttga cgaggcgcac
      361 catacaaacg acatgtccga gctgacgctg cgctatgagc gtgcgttata ccgcagcgat
      421 aatgccgcaa agctttggaa tgaatcggga cagttgtggg aaaatataat taaaagaaga
      481 tagtcttgac cgcatatcgt cctgttgtta gaataaatga atgttaaatg ggagcccggg
      541 agcgttaaaa agccgggctt ccggacaagt cttgccgaca gagggctgaa cgtgtgtcct
      601 ccgttttttc tgtgtcaaaa acttagagga gattaggtga caaccatgac gaagttagtg
      661 aatgaaatga ttcttgttct tgatttcggc agtcagtata accagctgat tacccgccgg
      721 atccgtgaat ttggcgtata tagcgagctg catccccata cgttgacagc tgaggaaatc
      781 aaagaaatga atccaaaagg aattatcctt tcaggcggac caaacagtgt atatgatgaa
      841 ggatctttcc gctgtgatga aaaaatcttt gaacttgata ttcctgtatt gggcatctgc
      901 tacggcatgc agctgatgac tcattacctc ggagggaaag tcgaggcggc aagccagcgc
      961 gaatacggaa aagcgaacat tcagattcaa ggaactcctg acttgttcaa agatcttccg
     1021 gaagaacaag ttgtctggat gagccacggc gacttagtcg tacaagtgcc ggaagggttt
     1081 acggtagacg cgacaagcca tcactgcccg aactcggcga tgagcaaaaa agacaaaaaa
     1141 tggtacggtg ttcagttcca tccggaagtc cgtcattcag aatacggaaa tgaccttctg
     1201 aaaaactttg tcttcgggcc ttgtgaatgt aaaggcgaat ggtcaatgga aaactttatc
     1261 gaaatcgaaa tgcaaaaaat ccgcgaaacc gtcggagaca aacaagtgct ttgcgctttg
     1321 agcggcggag tcgattcttc tgtcgtagcc gttttgattc ataaagcgat cggcgaccag
     1381 ctgacttgta ttttcgtaga tcacggcctt ctccgcaaag gcgaagcgga aggcgtcatg
     1441 aaaacgttca gcgaaggctt taatatgaat gtcattaaag ttgatgcgaa agacagattc
     1501 ttaaacaagc tgaaaggtgt ttctgatcct gagcaaaaac gcaaaatcat cggcaacgaa
     1561 ttcatttacg tatttgatga tgaagcggac aggctgaaag gaatcgacta ccttgcgcaa
     1621 ggaacgcttt acacagacat tattgaaagc ggaacggcaa ctgcgcaaac gatcaaatcg
     1681 caccacaatg tcggcggact tcctgaagat atgcagtttg aactgatcga accgctgaac
     1741 actcttttca aagatgaagt gcgcgcgctc ggcacagagc tcggcatccc ggatgatatc
     1801 gtatggcgtc agccgttccc gggccctgga cttggcatcc gcgtactcgg cgaagtaacg
     1861 gaagaaaaac ttgagatcgt tcgtgaatca gacgcgattc tgcgtgaaga agtggcgaac
     1921 catggccttg agcgcgacat ctggcagtac ttcacggttc ttcctgacat ccgcagcgtc
     1981 ggcgtcatgg gagatgcgag aacgtatgat tacacaatcg gtatccgtgc cgtaacatca
     2041 attgacggca tgacatctga ctgggcgcgt atcccttggg atgtgcttga agtgatttcg
     2101 acacggatcg tcaatgaagt gaaacacatc aaccgcgtcg tgtatgacat tacgagcaag
     2161 ccgcctgcaa cgattgagtg ggaataatga gaaaagcctc aaatctttta tttataaaga
     2221 tttgaggctt ttttaattta catggttcta ggaataatgg gccttttatc attaacaccg
     2281 gagaagatgt gcagcagttt tttatatatt cgagtttttt aatcagttgt attcctaata
     2341 ttctccctat aatttcattt tttctaataa aactgaattc ataaaatatt catttaataa
     2401 caaataatgt atgttattat gaatatatac aaataaaaca tatgatggtt tgtgttttcc
     2461 aaggggtttt ttatcttctg cattcagttc tttagaaacg cagaaggttt ctaatttgca
     2521 gaaaaaaatg ttgaaagagg ctcggaagga tggaaaaaca tattttattt tttaatgcta
     2581 cttatattaa aaaaatttct actttggaga ctgctaaaaa tttgggcttg acggtttctg
     2641 ttgtcggccc tgaactgcct gaatggtcgc ggccattcgt tgaccattac atttccgcaa
     2701 atacttatca gattgatgag actatagctg ttctgaagga aactgccaaa gaaaatcctt
     2761 ttgatggagt cattacattc tgggatagag atgtggttcc ggtggcggta actgcccgag
     2821 aacttaactt aaagggcagt ccggtggaag cggcagaacg ggctcgaaac aaatggaaga
     2881 tgcgtcaatg tttgaaccgc gcacaagttc ctcatccaaa atattgcaaa tttacaaatt
     2941 ggaccgaatt atatcatgca agcattgata tggaataccc attgatcgtt aaacctgtgg
     3001 gtgcttctgc cagtaaaggc gtattccgaa tatcaaagcc tgaagattta aatcgcgcat
     3061 atcagcagct gttaaacgcc gcggtgccgg aaaacgataa aatgttttct ttttatcaaa
     3121 acgagtatat tgttgaagag tttatgaacg gacaagaagt cagcattgag ggagtgattt
     3181 ccgacggagt cattcacttt gcaggtgtta ctgaaaaatg gacggatcag tatttcgaag
     3241 aataccagca tgcatttccc gccaggctgc cggaggctgt ggaacgtgaa ttattccaca
     3301 tcaccagtga agggataaaa gctttggagc tgaacaattg tggttttcat gccgaggtca
     3361 tgatcacaga gaaagggtgc aagattatcg agatcaacgg tcgtctgggc ggcgatttta
     3421 ttactaccca tttggttcct ctagccaaag gtataaatat aacgcgcgca aacctattgg
     3481 ctgtattagg agaaacaata agctttgaag cttcgaaaag aagagctgcc tgcgtcaggt
     3541 ttttaattgc agaccgtgct ggtgtgatag aaaagtggga aggtgtcgaa tcgatcaaag
     3601 aaatgcccgg ggtcgttgaa tttgttttag aaaagcagcc gggcgatcat gttggcctgc
     3661 cgcctgaaaa gtttcatgat tcccggattg cttatgtcat cacagaagcc gaagatacag
     3721 aaaaagcgat cgaatatgct gaaaatgctt tatctgaagt gaggtgtttc atcaatggag
     3781 aggaaaagac tgttcctgat cgggattcct gaaacgcata ttgagaaggc cgttacgagg
     3841 gcaaaacaac ttggttttga cgtcttatta ggagatacag aagcttcatt aaaaaaatat
     3901 gagcatttaa taaaggaagc tgaccaaaaa atcgcattag attataccaa tcatgagaat
     3961 ctattctcag tcgctaaaga aatccatgac aaagagcctt tagatgccat atttactttc
     4021 aaagaagccg gcttattcaa tgtatccaaa cttcagcagg catttcattt aaaaggaaat
     4081 cctccgtctg tggtgcaagc atgccttgat aaatatacaa cgcgccggct tttaaaaaag
     4141 gcaggactaa actctcccga ttttggattg tgcaggagcg tggaagacgt atacgatttt
     4201 tggaatacat ctcaacatcc tatcatttta aagccgagat ctcagcaagg cagtataggc
     4261 gtcataaaag ttgagaaaaa agaggacatt gaggcgtgtt ttaaagagtg ttcaaaacat
     4321 gacgaggaga agtcagtatt agccgaagaa tttatagaag ggcaggaaat ttcaatagaa
     4381 gccgttgtct gccaaggcaa ggtcgacata tttggtgtga ccgaaaagtt gctatacccc
     4441 gggacttttg tagaatctgg gcatatatcg ccgtataaac ataaagaaaa acatcaggat
     4501 ttgtataaga atctggtcaa ggaagttgtt catgccatgg ggatcgtatt tggccccttg
     4561 catattgaag ggtatcacac aaataaagga tttgtggttg gcgaggtaca cacccgctat
     4621 ggcggagaca acatagtgac cattacagaa atcgccatga aatgtgatat gcatacacct
     4681 atttttgcgg aactggcggg catcccatat caaccggaaa ggaaacatgc tcaaagcgaa
     4741 gtatgcgccg ttcgtttttt agaaacgaac caaggggttg tacgcgcaat caaagggatc
     4801 agcgatctca aaatgatggg gaatgtagta gattttcatg taaattgcag tgtcggtgat
     4861 agaatcagac cgatcaaaaa cagctacgat agagcaggat ggatgattgt aaaggggaaa
     4921 aatgagcgag aagtcaatca cgcattacat gatgcgattg acaaaataaa aataatcatt
     4981 aggtgaaggg gagaatgatg gtgaaaaaca gaaaatcatc aatttttaga gatgctttaa
     5041 acagtaaagg tttggtgaaa gttgcgggag ctcatgacgg tttaagcgcc aaattagcag
     5101 agaaaaacgg atttaatgcc gtatgggcaa gcggtttggg aatctcggct gtgcaaactg
     5161 tacctgatgc cagtatatta acgatgactg aatttcttga agccgccgtc attatgaatg
     5221 aatcatgcaa tttgccggtc atcgctgact gtgattccgg ctacgggaac attcacaatg
     5281 tcacccgcat gatcaaaaaa tacgaagctg ctggtattgc cggagtttgt attgaagata
     5341 aagtatatcc aaaattaaac tcatttgacg acagacaaca gatccttgtc agtactgaag
     5401 aattttgcgc aaaaattaga gccgcaaaga tggctcagca aaatgacgat tttgtattga
     5461 ttgcccgtgt cgaagcttta attgctaaat tgggtcaaga agaagcctat acaagagcaa
     5521 aagcttatgt tcatgctgga gcagatgcaa ttttaattca ttcaaaagaa caatcgcctg
     5581 atgaaattat tgagtttgtt aacaattggg acgtggatgc gccgttggtt gtggttccga
     5641 ctaaatatcc gacgctctca atggaacagc ttgagaaatt gggagtgaag gtttccatct
     5701 atgcgaatca ggcgttgcgc gcttctgtta aggctataaa tgatacattc gaaagcatta
     5761 taaataataa atcgtctttg cagattgaaa atgacatcgt gagcgttaat gagatatttg
     5821 acattcaaga cgttccgggg atgaagcaac tggagcgttt gatccataga cagccggcta
     5881 actgaggttt ttgtatcgtg ctattttaag aatggcccat aaagacattg gaggcgtttg
     5941 aattgaataa aagattatcc gatagagtca tgaatataaa accttcggcc actatgtcat
     6001 taaatgccaa aacgaagata atggtaaaag aaggaaaaga cattataaat atgagtgtcg
     6061 gagaaccgga tcttcatccg ccattaacag cctcatatgc aggaattcag gcaatagtga
     6121 aggggaaaac cggatatacg ccggcagcag ggctgattga attaagagaa tccattgtgc
     6181 gatatctgct taacgaacga ggtttagaat ataaaccaaa ccaaataatt gcatctgccg
     6241 ggggaaaaca gccgctatat aatgtttttc aagcaatttg tgatcaagac gacgaagtta
     6301 tcctcccttc accttactgg gtatcttatc cggaacaaat caaactgtcg ggggcggttc
     6361 ctgttattgt aagctgtgat gaaactacaa attttaaaat cacacccgag aagcttgcag
     6421 aagtaattac ccctaagaca aaagctgttg ttatcacatc tcccaataat ccgacagggt
     6481 ccgtttattc agaaaatgaa ctgaaagctt taggaaatgt gttgaaagat tattcaaaaa
     6541 tttttatcat ttccgacgaa atttatgatc agtttgtgta tgagggcaag catatcagtc
     6601 tgccgctcat ttttcccgaa ttgctgaatc ggaccatcat aacgaatgga ttttccaaag
     6661 tttttgcaat gactggatgg aggctcggct atatcgcagc cccatcggat atagccgaag
     6721 ccattgccag ctttcaaagc catgctacag gcagcccgtc aactatttct caatatgccg
     6781 gtatttctgc tttaaacggt tttgacaagt cgatggtcga agaatacaaa aaaagacgcg
     6841 atatattagt cgatggttta aatcaaattg agggcattca atgcaccaaa ccaaatggag
     6901 ccttttatgc gtttccgaac gtttcacaat ttttcggaac aatgtttgaa gatcaacaaa
     6961 taattgatgc ggagacattt tgtcatcttc tgttggaaaa acagcacgtg tcagctgttc
     7021 ccggcacagc attcggagag ccgaaaaaca ttcgtttgaa ttttgccatc ccaaaggatc
     7081 ttatcacaga ggctttgaaa agaattaata attttacaac tcagctggca gttaaggtat
     7141 aacagagcgc tgaaagctta aacgagcctc tttatatctg catctaatgt ttaggcaggt
     7201 ggttttttga aaggcatacg attaagaatt caccctgtgg gctggaatat cattttaggc
     7261 accttgttta gcagaatgtc agtctcgatg agcattccct tcctttctat ttacctaaca
     7321 caagtaaaag gtgtttctcc tgctttgacc ggcatcattg tttcagtaag ttcgctggct
     7381 gggattgtaa tgagctttta cggagggtat ttgtctgatc tttttggcag gaaaattgtg
     7441 atgataacgt ctgtattttg ttgggcgctt gtttttgtaa gttttatgtt tgcagatagt
     7501 gtactcgcat tttttgtcat caatgcgctt aacgggctgt gtcaatctat ctttgaaccg
     7561 gcgtcaagag cattattatc cgatataagc aaagaagaaa atcgtttgaa gatgtttaat
     7621 ttgcggtata ctgcgattaa tatcggcgta gttttcggtc ctcttttagg ccttagattg
     7681 ggagctgcca agacggctct cccatttctg ttcgcaggtt ttacatattt tctttatggt
     7741 ctatctctcg tattttcatt ccgaaaattt aaattagacg agaacaatcg aaaagaaaat
     7801 aaaacgacta ttgctacggc ttttaatgtg acaaggaaag acaaggtttt tcttatcaca
     7861 ttacttggag tgatattatc aatatccgga tatgcgcact tttctacaac attgccccaa
     7921 tattttgccg ccaaaataga ggacggggtg accatatttt catggctttt agctttgaat
     7981 gcaattgtcg tcttaattgt tcaataccct attgtgaata tcatgaaaaa gttcccgccg
     8041 attcattcaa tcattctggg aaatgcttta attagtttca gtttattatt tttttcgcta
     8101 tcggctaacc cattcatatg gggctctatc gtcgtgtttt tcacaatagg ggaagttttg
     8161 attttttcga tggttgatat gctggtggat gaaattgcaa aaccaggctt caaagggaca
     8221 tactttggag cagcaggctt taaccgttta ggaaatgtaa tcggtccttg gctgggaggg
     8281 attcttcttt ccttttttgg tgtaaacggg tccttctata tgtttttgat catttttata
     8341 acgacagcct cgggaattcc ggttttattt ttggcaaaaa aacatcttga taagagcgga
     8401 cgtttaaaag ttgatgtaac agaatctcat aggagttaaa tgttttaaca caatgaagaa
     8461 ttaatggcaa agtctttgaa cctcaaaggt ttaaaggctt ttttcttttc agcagcgacc
     8521 catcagaatg ggaaacaaga gtgtttatat ttttggggag aggaatacag actgaacggc
     8581 gaacaaagaa ggtattaatc taagggactg accccataag atgagacaaa taaaaaacac
     8641 cttcaagttt gaaaacggat cgttgttatc cgaaattaga ctttgaggcg ttttttttca
     8701 tctttttgaa accgttttgc cctgattcat atctaacagc ataggaggtg gataaggtga
     8761 aggaagaacg attgatcaaa aaggcgaaaa aaggtgatgc cgcagccttt gaaaaactga
     8821 tcacagcaca ccaggatact ttatataaaa cagcttatct ctatttgcat cacaaggaag
     8881 atacgctgga cgctgttcag gaaacggctt acaaggcttt tcttcatatc gcgcagctga
     8941 aggagccgaa atattttaaa acgtggctga tccggatttt gcttcatacg atttttgcga
     9001 tgaggaaaaa gcacggtgac gtcatcccgt ttgagccgca gcatgatacg cgcgcggaga
     9061 ataagaacat tgaagaatac atagatcttc ggaatgccct ggaaacgctt gacgaacata
     9121 tacagctgac cattcagctt tattattttc aagatttctc gattgctatg atcgctgaac
     9181 agaccggtat ggcggaaggc actgtaaaaa cgcatctgca cagggcgaga aaagcattga
     9241 agcaggagct ggaaaaggag gataaacata tatggaaaag catcaaatga agcaattgta
     9301 tcaggacatt gacgtgccga aagctgagtt gaaaaatgtg atacacagcg ccgctgtccg
     9361 tgccggaaaa gaaggcgccg tcagacggag atggggacga aaagtgataa acggcctcgc
     9421 ggttgctgct gctttgttta ttctgtatct gtcctcaggc ttattcatgc cctccgttaa
     9481 tacggctatg ggaaacattc ctgttgccgg acaaatttac agtctgtttc aggataaggc
     9541 aggttctgcg ctgtttaaaa gcaatttggt gacaaaactg aatgagaaag cggaatcacg
     9601 cggaatcacg gtgacagtga aaagtgtgta ttacgacagc ggacagctcg tttacaattt
     9661 taccgttgac aatttgaaat cagatgagga gagcatctct tttcaagttg attataaaga
     9721 tccatggaat atgttagcag aggattatga caacagtgat atgaaaaaaa tgaaagacgg
     9781 acggtacgcg ggacagcttc gcctgttcac ggacggctca aagctgaaag acggtgataa
     9841 gcttccgctt gtcattacaa aaatcaagga catcccggga aactggcgct ttacactccc
     9901 tattaaaaaa caaaagtccg tttctcttga aggaacgaaa gctgtgaatg taaatcacgg
     9961 attataccgc tttttcgata tccgggcgga aaacggaacg acgggatcgg ctctcttata
    10021 ttcagtcgac tttcatgatg cagccaaaaa tgatgccatc tcgatttacg aggcaacgga
    10081 tgatgccgga aaccattatg aaatgacggc gtcgaatatt gaacttggca gcagaaagaa
    10141 tcttccgggc ggcgggaaaa gaatacgcgg ccaaactcaa ttcagcaaac cgatagaccc
    10201 gaaagcgaaa acacttttca taacgggcga tataaaaaca gaatcagagc cgggagaaat
    10261 cgtgcctctg aaaacaaaac tgcccgtcag ttataaaacg aaacatcatc atgtcggcat
    10321 caccatcaaa aagatcaaac agcaaggcag acgggtaatc gtcgattatc aattcagcgg
    10381 aatcaattac agcaaggcgg atgaagatca gctgatcaat gtcggtgagt caatcggtct
    10441 cggcaatacg aaaaaaatga aaacctggcc atcgcttaat gagtatgaaa aaggctatta
    10501 tctgaaaggg aataaggcga aagtcacgaa ccttaaaacg ggtgaaatgg aatccgtttt
    10561 tgaattggat gattcatcca ataaagacta ttcgttgcgc gatttctcat tcgattcata
    10621 cgctttgtac gtcaatcaaa cggttatgaa cttgctggcg gatgataagg ggatcacatt
    10681 cgcggtgccg gttcggcctg cggacggaaa atgatgtctg gaaggcggct tttgccgtct
    10741 tccatttttg gtcaattaac gaataaacca aattttttta ccgggattgt tcgttttttt
    10801 tattgagttt tcaaaattga attgatacaa tagactcaga aatcaaatat gcagatatcg
    10861 tataatggcg gggatatggc ccgcaagttt ctaccaagct accgtaaatg gcttgactac
    10921 ggatcaatct caatcgtttg atataaataa tccattctta tttattcaga ctgaacgtat
    10981 gtagtcaagc gtcccaaatg tatttggggc gttttttatt tggcggataa cgggcagaat
    11041 aaatgggaga gaatgaagga ggcaattggc ttgaagcaat tttttcagtt tgatgagctg
    11101 gggacaagct atcgtaatga aatcatcggc ggtttaacga cctttttgtc aatggcgtac
    11161 attctgttcg tcaatccgct gacattgtct ttaaacggtg tgaagggatt tccggaagca
    11221 ttaaaaattg atcagggcgc ggtgttcacc gctacagcct tggcgtctgc ggccggctgt
    11281 attttaatgg ggctcattgc aaagtatccg atcgcgattg cgccgggtat gggattaaat
    11341 gcgttttttg ctttctctgt cgtcctcggc atggggattt catggcaggc tgcgctttcc
    11401 ggcgtcttga tttccggaat tatcttcgtg gcgctttcgc tgacgggact gcgggaaaaa
    11461 atcattaatg cgattccgcc tgagctgaaa ttggcggtcg gcgcgggtat cggtttgttt
    11521 atcacatttg tcggtttgca gggttcgggc attattgaag cgaactcatc gactctggtg
    11581 tctatcggca atattcacag cggccctgtg cttctgacgg ttttcggtgt tattgtgacg
    11641 gtcattctga tggtgcttcg cgtaaacggc ggcgtattta tcggaatgct tctgacggcg
    11701 gttgccggca tggtctgcgg actgattcca gttccgacgc acattgtcgg cagcgtgccg
    11761 agtcttgcgc cgactttcgg gcaggcgtgg atgcaccttc cggatatctt ctccgtacaa
    11821 atgctgattg tcattttaac tttcttgttc gtcgggtttt tcgatacggc cggaacgctg
    11881 gtggctgtag cgacacaggc cgggctgatg aaggaaaaca aacttccgcg tgcgggaaga
    11941 gcgcttctgg cagattcgac atcaatcgtt atcggagccg tactcggtac gtctacaacg
    12001 acttcttatg ttgaatccag ctcaggcgtt gcggcggggg cgcgctccgg cttcgcggct
    12061 gttgtcacgg gcattctctt tttgctggcg atgtttttct cgccgcttct gtcagtcgtc
    12121 accacgaatg tgacggctcc gg
//
