Select genomic region:
Overview
4.1
11.1
34.1
48.1

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaKEIKEFLO_6 (original name was: gnl|Prokka|KEIKEFLO_6)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | cyclic-lactone-autoinducer | 3,204 | 24,683 |

gnlProkkaKEIKEFLO_13 (original name was: gnl|Prokka|KEIKEFLO_13)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 11.1 | ranthipeptide | 333,564 | 355,229 |

gnlProkkaKEIKEFLO_36 (original name was: gnl|Prokka|KEIKEFLO_36)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 34.1 | lanthipeptide-class-ii | 1 | 7,795 |

gnlProkkaKEIKEFLO_50 (original name was: gnl|Prokka|KEIKEFLO_50)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 48.1 | lassopeptide | 1 | 1,718 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | cyclic-lactone-autoinducer | 3,204 | 24,683 |
Region 11.1 | ranthipeptide | 333,564 | 355,229 |
Region 34.1 | lanthipeptide-class-ii | 1 | 7,795 |
Region 48.1 | lassopeptide | 1 | 1,718 |

No secondary metabolite regions were found in these records:
  gnlProkkaKEIKEFLO_3 (original name was: gnl|Prokka|KEIKEFLO_3)
  gnlProkkaKEIKEFLO_4 (original name was: gnl|Prokka|KEIKEFLO_4)
  gnlProkkaKEIKEFLO_5 (original name was: gnl|Prokka|KEIKEFLO_5)
  gnlProkkaKEIKEFLO_7 (original name was: gnl|Prokka|KEIKEFLO_7)
  gnlProkkaKEIKEFLO_8 (original name was: gnl|Prokka|KEIKEFLO_8)
  gnlProkkaKEIKEFLO_9 (original name was: gnl|Prokka|KEIKEFLO_9)
  gnlProkkaKEIKEFLO_10 (original name was: gnl|Prokka|KEIKEFLO_10)
  gnlProkkaKEIKEFLO_11 (original name was: gnl|Prokka|KEIKEFLO_11)
  gnlProkkaKEIKEFLO_12 (original name was: gnl|Prokka|KEIKEFLO_12)
  gnlProkkaKEIKEFLO_14 (original name was: gnl|Prokka|KEIKEFLO_14)
  gnlProkkaKEIKEFLO_15 (original name was: gnl|Prokka|KEIKEFLO_15)
  gnlProkkaKEIKEFLO_16 (original name was: gnl|Prokka|KEIKEFLO_16)
  gnlProkkaKEIKEFLO_17 (original name was: gnl|Prokka|KEIKEFLO_17)
  gnlProkkaKEIKEFLO_18 (original name was: gnl|Prokka|KEIKEFLO_18)
  gnlProkkaKEIKEFLO_19 (original name was: gnl|Prokka|KEIKEFLO_19)
  gnlProkkaKEIKEFLO_20 (original name was: gnl|Prokka|KEIKEFLO_20)
  gnlProkkaKEIKEFLO_21 (original name was: gnl|Prokka|KEIKEFLO_21)
  gnlProkkaKEIKEFLO_22 (original name was: gnl|Prokka|KEIKEFLO_22)
  gnlProkkaKEIKEFLO_23 (original name was: gnl|Prokka|KEIKEFLO_23)
  gnlProkkaKEIKEFLO_24 (original name was: gnl|Prokka|KEIKEFLO_24)
  gnlProkkaKEIKEFLO_25 (original name was: gnl|Prokka|KEIKEFLO_25)
  gnlProkkaKEIKEFLO_26 (original name was: gnl|Prokka|KEIKEFLO_26)
  gnlProkkaKEIKEFLO_27 (original name was: gnl|Prokka|KEIKEFLO_27)
  gnlProkkaKEIKEFLO_28 (original name was: gnl|Prokka|KEIKEFLO_28)
  gnlProkkaKEIKEFLO_29 (original name was: gnl|Prokka|KEIKEFLO_29)
  gnlProkkaKEIKEFLO_30 (original name was: gnl|Prokka|KEIKEFLO_30)
  gnlProkkaKEIKEFLO_31 (original name was: gnl|Prokka|KEIKEFLO_31)
  gnlProkkaKEIKEFLO_32 (original name was: gnl|Prokka|KEIKEFLO_32)
  gnlProkkaKEIKEFLO_33 (original name was: gnl|Prokka|KEIKEFLO_33)
  gnlProkkaKEIKEFLO_34 (original name was: gnl|Prokka|KEIKEFLO_34)
  gnlProkkaKEIKEFLO_35 (original name was: gnl|Prokka|KEIKEFLO_35)
  gnlProkkaKEIKEFLO_37 (original name was: gnl|Prokka|KEIKEFLO_37)
  gnlProkkaKEIKEFLO_38 (original name was: gnl|Prokka|KEIKEFLO_38)
  gnlProkkaKEIKEFLO_39 (original name was: gnl|Prokka|KEIKEFLO_39)
  gnlProkkaKEIKEFLO_40 (original name was: gnl|Prokka|KEIKEFLO_40)
  gnlProkkaKEIKEFLO_41 (original name was: gnl|Prokka|KEIKEFLO_41)
  gnlProkkaKEIKEFLO_42 (original name was: gnl|Prokka|KEIKEFLO_42)
  gnlProkkaKEIKEFLO_43 (original name was: gnl|Prokka|KEIKEFLO_43)
  gnlProkkaKEIKEFLO_44 (original name was: gnl|Prokka|KEIKEFLO_44)
  gnlProkkaKEIKEFLO_45 (original name was: gnl|Prokka|KEIKEFLO_45)
  gnlProkkaKEIKEFLO_46 (original name was: gnl|Prokka|KEIKEFLO_46)
  gnlProkkaKEIKEFLO_47 (original name was: gnl|Prokka|KEIKEFLO_47)
  gnlProkkaKEIKEFLO_48 (original name was: gnl|Prokka|KEIKEFLO_48)
  gnlProkkaKEIKEFLO_49 (original name was: gnl|Prokka|KEIKEFLO_49)
  gnlProkkaKEIKEFLO_51 (original name was: gnl|Prokka|KEIKEFLO_51)
  gnlProkkaKEIKEFLO_52 (original name was: gnl|Prokka|KEIKEFLO_52)
  gnlProkkaKEIKEFLO_53 (original name was: gnl|Prokka|KEIKEFLO_53)
  gnlProkkaKEIKEFLO_54 (original name was: gnl|Prokka|KEIKEFLO_54)
  gnlProkkaKEIKEFLO_55 (original name was: gnl|Prokka|KEIKEFLO_55)
  gnlProkkaKEIKEFLO_56 (original name was: gnl|Prokka|KEIKEFLO_56)
  gnlProkkaKEIKEFLO_57 (original name was: gnl|Prokka|KEIKEFLO_57)
  gnlProkkaKEIKEFLO_58 (original name was: gnl|Prokka|KEIKEFLO_58)
  gnlProkkaKEIKEFLO_59 (original name was: gnl|Prokka|KEIKEFLO_59)
  gnlProkkaKEIKEFLO_60 (original name was: gnl|Prokka|KEIKEFLO_60)
  gnlProkkaKEIKEFLO_62 (original name was: gnl|Prokka|KEIKEFLO_62)
  gnlProkkaKEIKEFLO_71 (original name was: gnl|Prokka|KEIKEFLO_71)
  gnlProkkaKEIKEFLO_78 (original name was: gnl|Prokka|KEIKEFLO_78)
  gnlProkkaKEIKEFLO_83 (original name was: gnl|Prokka|KEIKEFLO_83)

Compact view
gnlProkkaKEIKEFLO_6 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,204 - 24,683 nt. (total: 21,480 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaKEIKEFLO_13 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 333,564 - 355,229 nt. (total: 21,666 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaKEIKEFLO_36 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 7,795 nt. (total: 7,795 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg34_4

ctg34_3
Leader:
MNSNEKHEEIDCAELERLAAFGG
Core:
S D D S Q I N P C S D V A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K G
Core with dehydrations:
Dha D D Dha Q I N P Cys Dha D V A Dhb Dhb Dhb A I I Dha A I Dha Dha V V Dha A I Dha N I Dha A A M Dhb K V P A Cys K P K G

#### MIBiG 3.1 matches for ctg34_3

17.4% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P
44
T I I +S S T C+P
7
T V K I I F R V S S H F G G N G G F G L F C T L S K E C Q P
36
17.4% BGC0002130 (QKI29070.1): Lanthipeptide: cacaoidin
8
P C S D V A T T T A I I S A I S S
24
P C+ A+ +A I S A +S
4
P C T I Y A S V S A S I S A T A S
20

#### antiSMASH-DB 4.0 matches for ctg34_3

100.0% NZ_QVFA01000004.1: Lanthipeptides: DW882_RS14120_lanthipeptide
1
S D D S Q I N P C S D V A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K G
46
S D D S Q I N P C S D V A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K G
1
S D D S Q I N P C S D V A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K G
46
93.5% NZ_JAQCXO010000012.1 and 1 other:
NZ_QVFB01000013.1 Lanthipeptides: DW855_RS14250_lanthipeptide
Lanthipeptides: PGY55_RS14505_lanthipeptide
1
S D D S Q I N P C S D V A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K G
46
S D D S Q I N P C S D V A T T T A I I A I S S V V S A I S I S A A M+K V P A C K P K G
1
S D D S Q I N P C S D V A T T T A I I G A I S S V V S A I S T I S A A M S K V P A C K P K G
46
30.4% NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide
Lanthipeptides: OCU69_RS05005_lanthipeptide
16
T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K
45
T I+S A I S+ V++ + I S A T A C K
2
T P I V S A I S A T V A S A T A I S A L F T V T S A C T T K
31
with 5 more sequence matches
26.1% NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
15
T T A I I S A I S S V V S A I S N I S A A M T K V P A C
42
T T ++S A I S+ V++ + +S A T A C
1
T T P V V S A I S A T V A S A T A V S A L F T V T S A C
28
23.9% NZ_QXPZ01000025.1: Lanthipeptides: D3H64_RS06235_lanthipeptide
15
T T A I I S A I S S V V S A I S N I S A A M T K V P A C
42
T T ++A I S++ I S N +T K +C
17
T T P E L T A I S A L T V G I S N F---V T K F K S C
41
21.7% NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
19
I S A I S S V V S A I S N I S A A M T K V P A C
42
+S A I S+ V++ + +S A T A C
1
V S A I S A T V A S A T A V S A L F T V T S A C
24
17.4% NZ_CP036170.1 and 1 other:
NZ_CP036170.1 Lanthipeptides: allorf_1760547_1760705_lanthipeptide
Lanthipeptides: allorf_1772186_1772344_lanthipeptide
13
A T T T A I I S A I S S V V S A I S N I S A A M T K V P A C K P K
45
++ T +S A S ++ S N+ + +P C +
3
S S A T P F L S A S S E C L A T F S N L E M Q H S P I P V C N F R
35
17.4% NZ_FOBB01000013.1: Lanthipeptides: BMZ54_RS31540_lanthipeptide
25
V V S A I S N I S A A M T K V P A C K P K G
46
++ A I S A T P C +G
16
I L G A I S Y A E C A S T G Q P T C N T Q G
37

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg34_3 - Class II
  Cleavage pHMM score: -2.80
  RODEO score: 0
  Monoisotopic mass: 4314.3 Da
  Molecular weight: 4316.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4334.9 Da N = 1
    4352.9 Da N = 2
    4370.9 Da N = 3
    4389.0 Da N = 4
    4407.0 Da N = 5
    4425.0 Da N = 6
    4443.0 Da N = 7
    4461.0 Da N = 8
    4479.1 Da N = 9
    4497.1 Da N = 10
    4515.1 Da N = 11

gnlProkkaKEIKEFLO_50 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 1,718 nt. (total: 1,718 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lasso peptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.