LOCUS gnlProkkaNPEPGNMH_7 25312 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|NPEPGNMH_7. ACCESSION gnlProkkaNPEPGNMH_7 VERSION gnlProkkaNPEPGNMH_7 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 06:22:07 Original ID :: gnl|Prokka|NPEPGNMH_7 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25312 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25312 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1484:5312]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1485..5312 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25312 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25312 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS 3..1448 /NRPS_PKS="Domain: Epimerization (15-318). E-value: 2e-163. Score: 536.9. Matches aSDomain: nrpspksdomains_ctg7_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (322-471). E-value: 8.2e-55. Score: 176.7. Matches aSDomain: nrpspksdomains_ctg7_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 139.4; E-value: 3.1e-42)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_1" /sec_met_domain="Condensation (E-value: 3e-87, bitscore: 285.9, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MVERAEGKQADQGPVEGEVILTPIQRWFFEKNFTNKHHWNQSVML HAKKGFDPERVEKTLQALIEHHDALRMVYREENGDIVQVYKPIGESKVSFEIVDLYGSD EEMLRSQIKLLANKLQSSLDLRNGPLLKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLE DFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLP KDCETEQRIVKDTSSVLCELTAEDTKHLLTDVHQPYGTEINDILLSALGLTMKEWTKGA KIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDISDADASAVIKTVKENLRRIPDK GVGYGILRYFTETAETKGFTPEISFNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALY ALSFSGMIRNGRFVLSCSYNEKEFERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSD FSAEDLEMDEMGDIFDMLEENLK" aSDomain 48..956 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_1_Epimerization.1" /evalue="2.00E-163" /label="ctg7_1_Epimerization.1" /locus_tag="ctg7_1" /protein_end="318" /protein_start="15" /score="536.9" /tool="antismash" /translation="EGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTL QALIEHHDALRMVYREENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKL QSSLDLRNGPLLKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESL VFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSS VLCELTAEDTKHLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDII PNVNISRTVGWFTAQYPVVLDI" aSModule 48..1415 /domains="nrpspksdomains_ctg7_1_Epimerization.1" /domains="nrpspksdomains_ctg7_1_TIGR01720.1" /incomplete /locus_tags="ctg7_1" /tool="antismash" /type="unknown" CDS_motif 63..92 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0001" /evalue="2.80E-05" /label="NRPS-E1" /locus_tag="ctg7_1" /protein_end="30" /protein_start="20" /score="16.7" /tool="antismash" /translation="LTPIQRWFFE" CDS_motif 153..227 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0002" /evalue="1.70E-06" /label="C2_LCL_024-062" /locus_tag="ctg7_1" /protein_end="75" /protein_start="50" /score="20.5" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVYR" CDS_motif 432..497 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0003" /evalue="3.00E-12" /label="NRPS-E2" /locus_tag="ctg7_1" /protein_end="165" /protein_start="143" /score="38.6" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 900..950 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0004" /evalue="1.20E-08" /label="NRPS-E5" /locus_tag="ctg7_1" /protein_end="316" /protein_start="299" /score="27.0" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 969..1415 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_1_TIGR01720.1" /evalue="8.20E-55" /label="ctg7_1_TIGR01720.1" /locus_tag="ctg7_1" /protein_end="471" /protein_start="322" /score="176.7" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKEFERA TVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 990..1049 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0005" /evalue="7.00E-12" /label="NRPS-E6" /locus_tag="ctg7_1" /protein_end="349" /protein_start="329" /score="37.3" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1083..1112 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_1_0006" /evalue="1.20E-03" /label="NRPS-E7" /locus_tag="ctg7_1" /protein_end="370" /protein_start="360" /score="11.2" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1485..1580 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg7_2_NRPS-COM_Nterm.1" /locus_tag="ctg7_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1485..5312 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg7_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 3.7e-119. Score: 389.1. Matches aSDomain: nrpspksdomains_ctg7_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 3.6e-112. Score: 366.8. Matches aSDomain: nrpspksdomains_ctg7_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.3e-25. Score: 81.3. Matches aSDomain: nrpspksdomains_ctg7_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1060-1266). E-value: 3.8e-37. Score: 120.7. Matches aSDomain: nrpspksdomains_ctg7_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 332.5; E-value: 8e-101)" /gene_kind="biosynthetic" /locus_tag="ctg7_2" /sec_met_domain="Condensation (E-value: 1.6e-93, bitscore: 306.5, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 2.6e-122, bitscore: 401.8, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 7e-18, bitscore: 58.5, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQRKKQ KDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAA ELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANIQGL VKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRIMGPGKLINCY GPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAVGELCISGMG VSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYLKNGGSDGLQ DVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEILLEFLNTQTVTVS" aSDomain 1512..2408 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="3.70E-119" /label="ctg7_2_Condensation_DCL.1" /locus_tag="ctg7_2" /protein_end="308" /protein_start="9" /score="389.1" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQRKKQKDGYEPKEL LFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1512..5282 /complete /domains="nrpspksdomains_ctg7_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg7_2_AMP-binding.1" /domains="nrpspksdomains_ctg7_2_PCP.1" /domains="nrpspksdomains_ctg7_2_Thioesterase.1" /final_module /locus_tags="ctg7_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1521..1562 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg7_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1584..1700 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg7_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 1917..1982 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg7_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 2028..2066 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg7_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2304..2399 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg7_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2448..2561 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0006" /evalue="1.00E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg7_2" /protein_end="359" /protein_start="321" /score="56.6" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 2892..4085 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_2_AMP-binding.1" /evalue="3.60E-112" /label="ctg7_2_AMP-binding.1" /locus_tag="ctg7_2" /protein_end="867" /protein_start="469" /score="366.8" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKE QAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANI QGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRIMGPGKLI NCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAVGELCIS GMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 3078..3119 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg7_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3312..3371 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0008" /evalue="9.20E-08" /label="NRPS-A_a3" /locus_tag="ctg7_2" /protein_end="629" /protein_start="609" /score="24.4" /tool="antismash" /translation="AYIMYTSGTTGKPKGNITTH" CDS_motif 3879..3968 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0009" /evalue="3.20E-13" /label="NRPS-A_a6" /locus_tag="ctg7_2" /protein_end="828" /protein_start="798" /score="41.8" /tool="antismash" /translation="PFGAVGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 4050..4115 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg7_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4404..4610 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_2_PCP.1" /evalue="1.30E-25" /label="ctg7_2_PCP.1" /locus_tag="ctg7_2" /protein_end="1042" /protein_start="973" /score="81.3" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYLKNG" aSDomain 4665..5282 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_2_Thioesterase.1" /evalue="3.80E-37" /label="ctg7_2_Thioesterase.1" /locus_tag="ctg7_2" /protein_end="1266" /protein_start="1060" /score="120.7" /tool="antismash" /translation="IFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLI QKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVES DVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDM PEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEILLEF" CDS_motif 4809..4883 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg7_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5341..6069 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 3.7e-55. Score: 179.7. Matches aSDomain: nrpspksdomains_ctg7_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 213; E-value: 5.8e-65)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_3" /sec_met_domain="Abhydrolase_6 (E-value: 4.5e-15, bitscore: 50.3, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 1.9e-06, bitscore: 21.1, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGI FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5383..6033 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_3_Thioesterase.1" /evalue="3.70E-55" /label="ctg7_3_Thioesterase.1" /locus_tag="ctg7_3" /protein_end="231" /protein_start="14" /score="179.7" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5566..5637 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg7_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg7_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6170..7396 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 339.3; E-value: 4.1e-103)" /gene_kind="transport" /locus_tag="ctg7_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHHSI" CDS complement(7411..7968) /locus_tag="ctg7_5" /transl_table=11 /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEEEMN RFKEIILKNTETKKLKFKKDQH" CDS complement(8022..8960) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 156.9; E-value: 1.2e-47)" /gene_kind="transport" /locus_tag="ctg7_6" /transl_table=11 /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT IAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPG FVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGMPAKK" CDS 9084..10418 /NRPS_PKS="Domain: Aminotran_1_2 (96-438). E-value: 4.2e-23. Score: 73.9. Matches aSDomain: nrpspksdomains_ctg7_7_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 264.9; E-value: 2e-80)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_7" /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-22, bitscore: 73.8, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCINK AIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCAMPF PNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFFYTMP RFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYL KSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKE KIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLEK QGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL" aSDomain 9372..10397 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_7_Aminotran_1_2.1" /evalue="4.20E-23" /label="ctg7_7_Aminotran_1_2.1" /locus_tag="ctg7_7" /protein_end="438" /protein_start="96" /score="73.9" /tool="antismash" /translation="DFQHCINKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFAD ERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEG LDIAKVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGD LEENKKADPLYAYDLSSHVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDC SMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPC MHTHLVLPQDLPASRVIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERG VK" CDS complement(10413..11087) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg7_8_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 193.4; E-value: 5.4e-59)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_8" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPEDITMVSYEE LL" aSDomain complement(10590..10778) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg7_8_ACPS.1" /evalue="6.00E-20" /label="ctg7_8_ACPS.1" /locus_tag="ctg7_8" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11192..11839) /locus_tag="ctg7_9" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12160..12903) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 222.5; E-value: 1e-67)" /gene_kind="transport" /locus_tag="ctg7_10" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(12917..13621) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg7_11" /transl_table=11 /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13608..14414) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.7; E-value: 1.6e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_12" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGE PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14530..15402) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 244.1; E-value: 2.9e-74)" /gene_kind="regulatory" /locus_tag="ctg7_13" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15492..16106 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_14" /sec_met_domain="Flavoprotein (E-value: 1.3e-32, bitscore: 105.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHLV VSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLAS IRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFY NRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16109..17530 /locus_tag="ctg7_15" /transl_table=11 /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGDK SPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMPVK REETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNVGI YRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLYDQ SEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYSGG RSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVAVN AMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVMWA LSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDSPL TTKEWEQKLMDLMNK" CDS 17547..17774 /locus_tag="ctg7_16" /transl_table=11 /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESIT NPEKYNPAFKIDPKETETAIEVPAVPERKA" CDS 17771..18235 /locus_tag="ctg7_17" /transl_table=11 /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR" CDS 18302..19147 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 63.5; E-value: 4.1e-19)" /gene_kind="biosynthetic-additional" /locus_tag="ctg7_18" /sec_met_domain="PF00561 (E-value: 2.1e-15, bitscore: 50.5, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 3.6e-09, bitscore: 31.0, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQK YQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEY ARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDIDKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLADVRM PVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFRKWLDQ " CDS complement(19187..20665) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 53.5; E-value: 2.3e-16)" /gene_kind="transport" /locus_tag="ctg7_19" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFTSKKAD KTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL" CDS 20945..22699 /locus_tag="ctg7_20" /transl_table=11 /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD TIDGNMIV" CDS complement(22653..22937) /locus_tag="ctg7_21" /transl_table=11 /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTTF AEWVVLLFFVLVLVREMYVIYKSKKKEPLKGGAFFRQSYCRLLYHCCVC" CDS 23063..24697 /locus_tag="ctg7_22" /transl_table=11 /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPESVSKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 agtacgtaga gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca 61 tcctgacgcc gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga 121 accaatcggt gatgcttcac gccaaaaagg gctttgatcc tgaacgggtg gagaaaacat 181 tgcaggcgct gatcgagcat catgacgcgc tccgcatggt ctaccgcgag gaaaacgggg 241 acatcgttca ggtgtataaa ccgatcggtg agagcaaggt cagcttcgaa atcgtggatc 301 tgtacggctc cgatgaagag atgctgagaa gccagattaa gcttctcgcg aacaagctgc 361 aaagcagtct cgatctgcga aacgggccgc ttttaaaggc ggagcaatat cgcacagaag 421 ctggggatca cctgctcatt gctgtacacc atctcgtggt cgacggtgtg tcatggcgga 481 ttttgcttga agactttgct tcaggctaca tgcaggctga gaaagaagag agccttgtct 541 tcccgcaaaa aacaaactcc ttcaaggatt gggcggaaga actggcggca ttcagccaat 601 cagcgcatct tttacagcag gctgaatact ggtcgcaaat tgccgctgaa caggtttctc 661 ctttacctaa ggattgtgaa acagagcagc ggatcgtcaa ggatacatca tctgtcctat 721 gtgaattaac ggcagaagac actaagcatc ttttaacaga tgttcatcag ccatatggaa 781 ctgaaatcaa cgatattctt ctcagcgcgc tcggtttgac aatgaaagaa tggacaaagg 841 gggccaaaat tggcattaac cttgagggac acggccggga ggacattatc ccgaatgtga 901 atatctccag aacggtcggc tggtttacgg cacaataccc tgttgtgctc gacatatctg 961 acgcagatgc ctcagctgtg atcaaaacag tcaaagaaaa cctgcgccgc attccggaca 1021 aaggtgttgg ctacggcatt cttcgttatt tcacagaaac agcggaaaca aagggcttca 1081 caccggagat cagcttcaac tatttgggcc aattcgacag tgaagtcaaa accgatttct 1141 ttgaaccgtc cgctttcgat atggggcgcc aagtaagcgg agaatcagag gcgctgtacg 1201 cattaagctt cagcggcatg atcagaaacg gccggtttgt gctttcctgc tcctacaatg 1261 agaaggagtt tgaaagagct acagtcgagg agcaaatgga acggtttaaa gaaaacctcc 1321 tgatgctaat ccgccattgc acggaaaaag aagacaagga attcacacca agcgacttca 1381 gcgccgaaga ccttgaaatg gacgagatgg gagatatctt tgacatgctt gaggagaatt 1441 taaaataaaa cgcaagggaa ttacagaagg cgggagcgaa acatatgagt caatttagca 1501 aggatcaggt tcaagatatg tattacctat cgccgatgca ggaagggatg ctttttcatg 1561 ccatcctgaa tcccggccaa agcttttacc ttgaacaaat cacgatgaaa gtaaaaggca 1621 gcttgaatat caaatgtctt gaagaaagca tgaatgtgat catggaccgg tacgatgtat 1681 ttcgtaccgt gttcattcac gaaaaagtaa aaaggcctgt ccaagtcgta ttgaaaaaac 1741 ggcagttcca tatagaagaa atcgatctga cacacttaac gggcagcgag caaacagcca 1801 aaatcaatga gtacaaagaa caggataaga tcaggggttt tgatttgacg cgggatattc 1861 cgatgcgggc agccattttc aagaaagctg aagaaagctt tgaatgggtg tggagctacc 1921 accacattat tttggacgga tggtgcttcg gcatcgtcgt acaggatcta tttaaggtat 1981 acaatgctct gcgcgaacaa aagccgtaca gcctgccgcc cgtcaaaccg tataaagact 2041 acatcaagtg gcttgaaaag caggataaac aagcatcact gcgttactgg cgcgaatatt 2101 tagagggctt tgaaggacaa acgacgtttg cggagcaaag aaagaaacaa aaggacggct 2161 atgagccgaa agagctgctc ttttcactgt cggaggcgga aacaaaggcc tttaccgagc 2221 ttgcaaaatc gcagcatacc actttgagta cggcgctgca ggcagtctgg agcgtattga 2281 tcagccgcta tcagcagtct ggcgatttgg ccttcggtac agttgtttca gggcgtcccg 2341 cggaaatcaa aggcgttgaa catatggtcg ggctgtttat caacgttgtc ccgagacgtg 2401 tgaagctgtc tgagggtatc acatttaacg gcttgctcaa gcggctgcag gagcaatcgc 2461 tgcagtccga gccgcatcaa tatgtgccgc tttatgacat ccaaagccag gccgatcagc 2521 cgaaactgat tgaccacatc attgtttttg agaactatcc gcttcaggat gcgaaaaatg 2581 aagaaagcag tgaaaacggc tttgatatgg tggatgttca tgtttttgag aagtcgaatt 2641 atgatctcaa cctgatggct tccccgggag atgagatgct gattaagctt gcctataatg 2701 agaatgtgtt tgatgaggcg tttatcctgc gcttgaaatc tcagcttctt acagcaattc 2761 agcagctcat ccagaatcct gatcagcctg tcagcacgat caacctcgtt gacgacaggg 2821 agagagaatt tttgctaacc ggcttaaacc cgccggctca agctcatgaa acaaagcctc 2881 tgacgtattg gttcaaggaa gcagtgaacg ccaatccgga tgcaccggcg cttacgtatt 2941 ccggccagac cctgtcttat cgcgaattag atgaggaagc gaaccgcatt gcacgccggc 3001 tgcaaaaaca cggtgcgggc aaaggctctg ttgtagcgct gtacacgaag cgctcacttg 3061 aactggtgat cggcattctc ggtgtattaa aggcgggagc agcctatctg ccggttgatc 3121 cgaagctgcc agaggaccga atctcgtata tgctggctga cagtgcggca gcctgtcttc 3181 tgacgcatca ggagatgaaa gaacaagcgg ctgagctgcc gtatacaggc acaacgctct 3241 tcattgatga tcaaacacgg tttgaagaac aggcaagcga tcctgcaacc gcgattgatc 3301 ctaatgatcc ggcatatatc atgtacacgt ccggcacaac cggaaagcca aagggcaata 3361 tcaccactca tgccaatatt caaggattgg tcaagcatgt agactacatg gcattttctg 3421 atcaggatac gttcttgtct gtttcgaatt acgcctttga tgcatttacc tttgatttct 3481 atgcttctat gctgaatgcg gcacggctca ttatcgcaga tgaacatacg ctgcttgata 3541 cagaacggct cacagatctg atcctgcaag agaatgtcaa tgtcatgttt gcgacaaccg 3601 cactatttaa tcttctcaca gatgcgggag aggattggat gaaggggctt cgctgtatat 3661 tattcggcgg agagcgcgcg tcagtgcctc atgtcagaaa agcgctgcgg atcatggggc 3721 cgggcaagct gattaactgc tacgggccga ctgagggaac agtgtttgcg acagctcacg 3781 tcgtgcatga tctgccggat tccatctcct cattgccgat cggaaagccg atcagcaatg 3841 ccagtgttta tattctgaat gagcaaagcc agctccagcc attcggggcg gtcggtgaac 3901 tgtgcatcag cggaatgggc gtgtcaaaag ggtatgtaaa tcgtgctgac ctcacgaagg 3961 aaaagtttat cgagaacccg ttcaagccgg gagaaacgct ttaccgtaca ggggatttag 4021 cgcgctggct gccggatgga acgattgaat acgccggccg tattgacgac caggtcaaaa 4081 tacgcggaca ccggattgag cttgaagaaa tcgaaaagca gctgcaggaa tacccaggtg 4141 tgaaagatgc ggtcgttgtg gcggaccgcc atgagtctgg cgatgcatca atcaatgcct 4201 accttgtgaa ccgaacgcag ctttcagctg aagacgtgaa ggcgcacctg aaaaaacagc 4261 ttcctgctta catggtgccg caaaccttta ccttcttgga tgagcttcct ttaacgacga 4321 acgggaaagt caataaacgg ctgctcccaa aacctgatca ggatcagctg gcggaagaat 4381 ggattggacc gcggaacgag atggaagaaa caatcgcaca aatatggtct gaggttctcg 4441 gcagaaagca aattggcatt catgacgatt tctttgcgct cggagggcat tccttgaagg 4501 ccatgaccgc cgcgtcccgc atcaagaaag agctcgggat tgatcttcca gtgaagcttt 4561 tgtttgaagc gccgacgatc gccggcattt cagcgtattt gaaaaacggg ggctctgatg 4621 gcttgcagga tgtaacgata atgaatcagg atcaggagca gatcattttc gcatttccgc 4681 cggttctggg ctatggcctt atgtaccaaa atctgtccag ccgcttgccg tcatacaagc 4741 tatgcgcctt tgattttatt gaggaggaag accggcttga ccgctatgcg gatttgatcc 4801 agaagctgca gccggaaggg cctttaacat tgtttggata ttcagcggga tgcagcctgg 4861 cgtttgaagc tgcgaaaaag cttgaggaac aaggccgtat tgttcagcgg atcatcatgg 4921 tggattccta taaaaaacaa ggtgtcagtg atctggacgg acgcacggtt gaaagtgatg 4981 tcgaagcgtt gatgaatgtc aatcgggaca atgaagcgct caacagcgaa gccgtcaaac 5041 acggcctcaa gcaaaaaaca catgcctttt actcatacta cgtcaacctg atcagcacag 5101 gccaggtgaa agcagatatt gatctgttga cttccggcgc tgattttgac atgccggaat 5161 ggcttgcatc atgggaagaa gctacaacag gtgtttaccg tgtgaaaaga ggcttcggaa 5221 cacacgcaga aatgctgcag ggcgaaacgc tagataggaa tgcggagatt ttgctcgaat 5281 ttcttaatac acaaaccgta acggtttcat aaatgaagtg atgaaaggag gagacagcca 5341 atgagccaac tcttcaaatc atttgatgcg tcggaaaaaa cacagctcat ctgttttccg 5401 tttgccggcg gctattcggc gtcgtttcgc cctctccatg cttttttgca gggggagtgc 5461 gagatgctcg ctgccgagcc gccgggacac ggcacgaatc aaacgtcagc cattgaggat 5521 ctcgaagagc tgacggattt gtacaagcaa gaactgaacc ttcgccctga tcggccgttt 5581 gtgctgttcg gacacagtat gggcggaatg atcaccttca ggctggcgca aaagcttgag 5641 cgtgaaggca tctttccgca ggcggttatc atttctgcaa tccagccgcc tcatattcag 5701 cggaagaaag tgtcccacct gcctgatgat cagtttctcg atcatattat ccaattaggc 5761 ggaatgcccg cagagcttgt tgaaaataag gaggtcatgt cctttttcct gccttctttc 5821 cgatcagatt accgggctct tgaacaattt gagctttacg atctggccca gatccagtcg 5881 cctgttcatg tctttaacgg gcttgatgat aaaaaatgca tacgagatgc ggaagggtgg 5941 aagaagtggg caaaagacat cacattccat caatttgacg gcgggcacat gttcctgctg 6001 tcacaaacgg aagaagtcgc agaacggatt tttgcgatct tgaatcagca tccgatcatt 6061 caaccgtgat caaaagcgga cagcttcggc tgttccgctt tttttgtgtt gaatgccaat 6121 ttctgcatgg tataatagtc gaaatactca aataaaggca ggtcgaaaca tgcgcacgtc 6181 tcccaggatg aaatggtttg tattgctgtt tacgtttgtt ttcgccatcg gaatgaactc 6241 attcagaaat tcctttcaat tttttatgct gccaatggca gacgccttcc atgccgacag 6301 gtcgctgatt tcggtttctg tcagcatttt tatgatcaca accggcatcg tccagttttt 6361 tgtcggtttt tttatcgacc gtttcagtgt cagaaaaatt atggcgctgg gagctgtttg 6421 catcagcgca agctttttgg tgcttcctta ttcaccgaat gttcatgtgt tttccgccat 6481 ttacggtgtg cttggcggaa tcgggtattc ctgcgcggtc ggcgtgacga cccagtattt 6541 catcagctgt tggtttgaca cacacaaagg tctggcgctt gctattttga ccaatgccaa 6601 ctctgcgggc ctgctgcttc tctcgcccat ttgggctgcg gctccgtatc atgccggctg 6661 gcagagcacc tataccattt tgggaatcgt catggcggct gttctgctgc cgctcctcgt 6721 ctttgggatg aagcacccgc cacatgcgca agcggaaact gtgaaaaaat cttatgattg 6781 gcgagggttt tggaacgtga tgaagcaatc ccgcctcatt catatcctgt acttcggcgt 6841 gtttacttgc ggatttacaa tgggaattat tgatgctcac ctcgtcccga tactgaagga 6901 tgcgcatgtc tctcatgtca acggaatgat ggccgcgttc ggggcattta tcatcattgg 6961 cggattattg gcgggctggc tgtcagatct cctcggcagc agaagcgtca tgctatccat 7021 cttatttttc attcggctgc tcagcctcat ttgcctgctc attcccattc tcggaattca 7081 tcacagcgac ctttggtact tcgggtttat cctgttattc gggctcagtt acacaggcgt 7141 gatcccgctg accgcggcgt caatttcgga aagctatcaa acaggattga tcggatcgct 7201 gttaggcatc aatttcttta tccatcaggt tgccggagct ctcagcgtgt atgcgggcgg 7261 tttgtttttt gacatgactc atggttattt actgattgtc gctgtgtgca tcgtgtttgt 7321 gggtttatcg gctgtaatag agctggtgcc gtttttagat aaacagaagg caaaagaaac 7381 ccaccattca atataaaagg atcagcactg tcaatgctga tcctttttaa atttgagttt 7441 ttttgtttcg gtatttttaa ggataatctc cttgaatctg ttcatctcct cttcggagtg 7501 aaaaaaatgt ttggggatcg caatatattg gccacttgat gtattgaccc tgaagatatt 7561 tttatattcg aaaacagctg taatttcatc ccaattgaaa atgaggtcat attttttaga 7621 acatatacga attccttctt ggttcagagt atatgttctt ttggatttca tccgttcgtt 7681 cttcttgtat gctctggaaa acttcacata tagaagaagg aggagcagca gtgtaaacag 7741 aacggacatc acgataatca acatactgtt cataaacaag ttaagcgcgt cacttccata 7801 aacgatacgg ggccatccgt taatgaagtt aactgcagca aatatggcgc aaaacaatag 7861 aaagtaaaag catgatattt ttgcgatttg ataaaaaaag atttctctta catccttaaa 7921 agtgatttct cctggaagat tgatactttc actagcatat tgaatcatac ggtaaaccta 7981 cacctctaac catgtttttc cttttagtct agcataattt ctcatttttt tgcaggcata 8041 ccagggcgct ttgttttttt ctccagattg atattgctcc ccaccacgcc aatcataata 8101 caaacagccc cggcaagatg ataccaggcc aggctttcgt tgagaatcac aaatcctgca 8161 atcatcgtca caatggtaga tacatgatta aaagcgctca ttttaaacgc ctcaattcgc 8221 gacagcgtat agttagacag aaatgaagtg acaagtgaag acagcacgcc caaatacaca 8281 atggcgagaa cgaagccggg ctcccggaac ggcagaaaat aagtgccgac tgttcccgcc 8341 gctccgtgac gcacaagggc gatggcgttg aagacgacaa agccgatggc tgacatgatg 8401 taggtgagct cggtcagctt gaaccgctgc gtcatttttc tggcagcagt attgtacatc 8461 gctgaagaca aagcggacaa taggatcagc aaagaccctt ttaagctggc tgattccacg 8521 tcaacgcctt tcatcacaaa aataaacatg acgccggcaa cggataaaac cgtgaacccc 8581 ttttgcgtcc acgttgggcg ttcctttaaa acataagcgg caaagaccat cgtgaaaatc 8641 ggaatggctg cctgaataat tcccgcttca gaggaggacg agtacacaag gccgaatgcc 8701 tgaaagctga aaaataacgc gggatacagc agggcgagcg gcaaaatgtc aatgacgtcc 8761 tttacgcgga ttgatagctt tacccagccg aataagatcg gtacagtggc cgcagcaaac 8821 gcaatggtga accgatgcgc caaaatatca aacggctctg ctgtttgcag tgcgattttt 8881 acgaatagaa aggataaacc gataatgaac gaatataaaa tagccgctat ataagcgggg 8941 gtttgctgat gtttaaccat aatgggaagg gctcctttac ctgaattgca gcgccggtcg 9001 ctccctttat tgtatggccg cggtcagaac ggtacaatga gaaaaacaat gaactgtacc 9061 ggtacaaaac agggggagaa ggcatggaga aatatatgag tctattaacg aggatagagg 9121 agatgatgca aagcacctca tatcaagaag gagacaggct tccatctatc cgtcagctgt 9181 ccgcccgcta ccaagtcagc aaaagcacag tgatccgcgc gctgcaggag ctggaaaagc 9241 gccaccttat ctattctgtt ccgaaaagcg gctattatat tgtgaaaaag tcagggaaat 9301 caaaaagcgg gcagcctggc cccatcgact ttgccacatc tgcgccggat cccgatgtgt 9361 ttccgtatct tgattttcag cactgcatca acaaagcgat tgatacatac aaaaacgatt 9421 tgtttattta tgggacgcca aaggggcttc catcactcat ccgcgtactc cgaaagctct 9481 tggccactca acaggtattt gcggatgaac ggcatatttt cattacatca ggtgtccagc 9541 aggcgttatc cttgctttgt gccatgccgt tcccaaatgg gaaagagaag atcgccattg 9601 aacagccggg ctaccatttg atggtcgaac agcttgagac acttgggatt cccgccatcg 9661 gggtgaaacg aacggaagaa gggcttgata tagccaaggt tgagcggtta tttcaaacag 9721 aatcgattaa atttttttat acgatgccgc gcttccataa cccgcttggg tgctcattgt 9781 cagagcgtga taaacaggag cttgtgagac tggcagaagc gtatgatgtc tatctcgttg 9841 aggatgatta cctcggtgat ctggaggaaa ataaaaaggc agatccgctg tacgcatatg 9901 atctgtcctc acatgtcatc tatttgaaaa gcttctcgaa aatgatgttc cccggcctcc 9961 gcgtgggggc ggctgttttg cccgaagcgc tgactgacac gttctatgcg tacaaaaagc 10021 tgaacgacat cgactgttcg atgatttctc aagcggcatt ggagatttac ctgaaaagcg 10081 gtatgtacgg caggcataag gagaaaatca gagattctta taaagagcgg tcgctgaggc 10141 tacatcaagc cattcgaact cacaggcagc tgggaagcgg acgctttacg ttctccagcg 10201 ggcaggcacc ctgtatgcac acccatctgg tgcttcctca ggatctgccc gcctcaagag 10261 tgattcatag actggaaaaa caaggggttc tccttgaggc gatagaccgt cattatttat 10321 cagattatcc gaaagaaaat ctattaaaaa tcaatatttc caatgtgaaa acggaagata 10381 ttgagcgcgg tgtcaagctg ttgatgagcc atttataaaa gctcttcgta cgagaccatt 10441 gtgatatcct cggggaaatc agggtgtacg gcgcatacag ccattttgta gccgggatcg 10501 acctcatacg ttttgatata gcatggggaa tggctgtccg gaagctcaat ggatacttgt 10561 ccgtcctggt gcaggcgcac tgaaaaggaa tcaagcggaa gcgataagcc tttgccttcc 10621 tgtttgataa agctttcttt cattgaccat agatgataaa aatagtctgt ctgctcgtcc 10681 ttgtcttttg ctaaaaggtc gctgtactct gtttttgaaa agaagcgctt ggcgatctca 10741 aggctgatcg gtttcgtttt ttcgatatct atgccgatcg gctgtgaatc aaacgcgcaa 10801 atgacccagc gtccggagtg agaaatgttg aaatgagcgt cgggaagatc agggatgcac 10861 ggcttcccgt attcctgcgt gctaaagcgg atatcggatt tgtccaactg atactgcctg 10921 cttatgactg agcgaacgag cacatctccc agcagggtgc ggtgagcatc ttctttatga 10981 taaaatctcc ggcatttctc ccgtttttca ggtgatatga aagacatgaa ccgttcattt 11041 tcttcctgtg aaagcgggcg gtccatataa attccgtaaa tcttcattct agatcctccg 11101 tctgcaaaag attgtcaaaa ccatcctatc atacttccac aagactcata tagaggagaa 11161 aataaaaaaa caaagccaag gcggctttgt tttagtgtac aggcggagat gctttcactg 11221 cggctgtccg ccttgccaca gcataattca gcaactggat tgactggggc aatgaaaaac 11281 gcaaaataag tccggtgagg atggcggtca aaatggtgcc aaaaccgatc ggtccgccca 11341 tgccccatgc cgcaaacaaa atggttaatt ccatgccgtt ccgcacccat tgcacattcc 11401 agccggtttt ttctgtaatc agcatcatca gtgaatcacg cggccccgcg ccaaggcctg 11461 ctgatacata aacaccgacg ccgtaaccaa tcagcaccac gcctagagag aagacgatga 11521 tcgagcctgt gtaggtcgag agggcaggca gaatgaaatt gaaaaaatct ataaatacac 11581 caatgagcac catattcagg agggcaccaa ttttcggcca agctctcgta aacaatgacg 11641 tgaatccgac gatgagcgct ccaataatga tggaccactg gccgacggta agcccgaagt 11701 gctgaaacag gctgtaatga aatgcatccc acggactaat gccgagtgct tttccttcta 11761 tcgtcaggga tacaccaaaa gccaaaatga tcaaaccggc aaaataaaat gtccagcgca 11821 gaacaagttc ttgcttcacg tgaggtccct tctttcgtaa aaatcagtcg attgtcattg 11881 tagcacatct gacagaaggg cggaataggc gaaaggggct caacaaaaaa acagggccgc 11941 cggaggcgcc ctgtttcagc gtgttggcaa acccttgcat tcgttgtcag gcctgtgctt 12001 cggtgctcac gaatttaaca ttagctgtgc tccaatgctc gcccttccta gacttcaaag 12061 gttttcaatc acgctgaaaa tcacaaaatc ctaaaacgaa tatcgtttta ggattttgtc 12121 aataatctga aacagggcgc tgacgctctg tttttcttat tacagcgggt tcaaaatccg 12181 gtttaagaac cgctgtgtcc gttcttcttt tggtgcggag aaaatttgct ccggcggtcc 12241 ctgctccacg ataacgccgc cgtcgatgaa gatgacttca tccgcaacct cctgcgcgaa 12301 cttgatttcg tgggtcacga cgaccatggt ccagccttca ttggccaagt ccttgataac 12361 cttcagcacc tctccgacaa gctcgggatc aagcgctgag gtcggttcgt caaacagcat 12421 gagctcaggc tgtatcgcca gtgcgcgggc gatgccgacg cgctgctgct ggccgccgga 12481 aagctggaac ggatataaat ccattttgtc cttcaatccg actttatcaa gaagctgaat 12541 cgcttctttt ctgacttcct ctttgttccg tttttgcacc tgaacagggc cctccatcac 12601 gttttcgagg gctgtgcggt gcgggaacag gtgatacgcc tgaaacacca ttccggattt 12661 tcggcgaagc tttaggatat ccgcctgttt cacctttttg gagaaatcga tggagaaatc 12721 atcaaatgca agctctccgc gattcgggat ctccagagcg ttcaggcagc ggagcagcgt 12781 cgttttccct gaacctgaag gcccaagtat ggcgatgact tttccttttt caatcttcat 12841 atctatcttt tttaaaattt cattttcacc gaatgatttg tttaatcctt taacggtaag 12901 catactcgga acctccttat ttggccacgt agcggtcaag acgccgttcg atgacatgct 12961 ggacgagtga gagcaggaag cagataatcc aataaataaa ggctgcttca atatagatca 13021 ctaaaatttg atcaagattc cgcgcgccga tttcctgggc ttttctgaac agctcagcga 13081 ccagaatttg agaggcgagg gatgtatctt taatcaggct gataaaggta ttggataatg 13141 gcgggatcga cacacgaaac gcctgcggca aaatgacgcg gaacagcgtt ttttgatgtg 13201 tcatgccaat tgtgtagccg gcttcccatt gccctttcgg cacggataaa atagatgccc 13261 gaatgatttc agatgcatag gcgccgacgt ttaatgaaaa ggcgataact gcgcttggaa 13321 atggatctaa tgtgacgtta aaggccggga acagatagaa aatgatgaac aattgaacga 13381 gaagaggagt gccgcgtatt gcggatacgt atacgctgaa cacccatctc aaaggtctca 13441 ctttcgacat tctggcaagc gccgtaatca gcgccaggat cattccgaat ataaaggaaa 13501 gaatcgtaag gggaatcgta tagtagattc cccctgaaag tatcggccag aatgactgct 13561 gcaccagatc ccacgggatc gccgtgccaa gcgtcaatgc cggcagatta tttagaaaca 13621 tcttcgccga accatttttt agaaatttta gaaagagtcc cgtcctcttt catttctttt 13681 aatgctttgt tgacttgatc aacaacctcg ccgcttcctt tacggaacgt gaaatatgtt 13741 gactgaggct cacctgtttc aaacgcgatt ttcacgtttt tattgccaga tgtttttaag 13801 tagttcaata cggcaagctt atcgttgtat gtcatatcga cgcggccttg ctggatcatt 13861 tgaagggcct gcgccatgcc ttcaacgcct tctactttag cgccggcatt tgtagctaat 13921 ttgttgtagt tgcttgtcag tgattgagct gacgtttttc cttttacatc tgcttcagac 13981 ttaatatcgt tgttgtcttt tttcgttacg acaacggctc ttgatgttgt gtatttatct 14041 gagaaatcat atttgtcttc acgatctgtt tttccgactt ggttggcaac aacgtcaaac 14101 cgtttggaat tcaggccggc aaacatactg tcccattgtg tttccttaaa gtcgacttta 14161 agcccgaggc gttttgcgac ttctgtgata acttcgacat catagccagt cagtttatca 14221 gtgtctttgt cgtggtaagt gaacggctca tatgttcctt ccgttccgac tgtgagcaca 14281 ccttttttct taattgaagc ccaaagatcg ccatctttgg cattatcttt tgactgattg 14341 tcatttcctg ctccgcaagc tgcaagagct gcaatactta cgaccatgaa taaagccaat 14401 aatgcttttt tcatcttatt ccccactttt ctggttgatt ttattgaaat aaaaaattag 14461 cttacaaatc taaaggataa ctttttttta gtatgagtca agtatttggt tttcataaga 14521 caaaatcttt taaaataaat ccaaaaattg ctgtgccggt ttaggcaaat aactgtccgt 14581 tctccacatg acagccggtg tcataatgaa gggattattt tcgatatgga cggtgtgaac 14641 gtgatttctc atatgaacgg gaatcattgt gacaggcaaa atagacgcgc cgaatccgga 14701 tgacacgagg ctgagcaaag ttgcagagtc gtggcattca caaacaatgc gcggctccag 14761 gttcaaacga tgaaattcat tcatgacctg attatagacg ccttttccgt tgacaggccg 14821 cagcaggatc agcggaaatg aaggaatgtc caccatctta atggtgtctc cgcacggata 14881 tccggcttca tctgaaagca cgagcacaca tggaatgtca tcaagctgct tgaattgtac 14941 tgtgtcactt ttgatcagtg ttgtcgtgac cgccgcatcg atttgccggc tttccagcag 15001 ttccaacagt gtcgcgggtt cattttccca aatattaaag gtgagatggg ggtatctctc 15061 tttgatctgt gttacttttt caagcatcag agccgcgcaa taaatcgttg atcccacggc 15121 aagtgtaccg gctacttcct ccttcagctc ctgtacctca atgactgcat cttcaaacct 15181 atgcagaatc tcttttgctc tttttagaaa aacagctcct tcatatgtaa gagtcatttg 15241 ttttttcttg ttacggtcaa acagaacaac accaagttcg tcctccagct gtttgagctg 15301 cctgcttaaa ggcggctgcg ccatgtgaag ctttttggct gcggacgtaa ttttctgttc 15361 ttgggcaatg gtaatgaagt atcgaagctg gcgaatatcc aaaagaaagc gcctccttat 15421 catacctttt aggtattaat tatagattta atagatattt ttcatatgga tatatcagga 15481 gtatgattga aatgaaagca gaattcaagc gtaaaggagg gggcaaagtg aaactcgttg 15541 tcggaatgac aggggcaaca ggggccattt tcggggtcag gctgctgcag tggctgaagg 15601 ccgccggagt ggaaacccat ctcgttgtgt ctccttgggc aaacgtcacg atcaaacacg 15661 aaacaggcta tacgttacaa gaagtagaac aactggccac atacacttac tcacataagg 15721 atcaggcggc agccatttca agcgggtcgt ttgataccga tggaatgatt gttgcgccgt 15781 gcagcatgaa atctctcgca agcattcgca caggaatggc ggataatctg ctgacacgtg 15841 cggcggatgt catgctcaag gagagaaaaa aactcgtcct cttaacgaga gagacgcctt 15901 tgaaccaaat tcatctcgaa aatatgctag cgcttacgaa aatgggcacc atcattcttc 15961 ctccgatgcc ggcattttat aatcggccga gaagcttaga ggaaatggtt gaccatattg 16021 tttttagaac gttggaccaa ttcggcattc ggcttcctga agcgaagcgc tggaatggga 16081 ttgaaaaaca aaaaggagga gcttgatcat ggcttatcaa gatttcagag aatttctcgc 16141 tgcccttgaa aaagaaggac agctgcttac agtgaatgaa gaggtaaagc cggaaccgga 16201 tttaggggcc tccgcacggg cagccagcaa tcttggcgat aaaagccctg cgctcttatt 16261 taacaacatt tacggctatc ataacgcgcg aattgcgatg aatgtcatcg gctcttggcc 16321 aaaccatgcc atgatgctgg gcatgccgaa agacacaccg gtaaaagaac agttttttga 16381 attcgcaaag cgttatgacc agtttccgat gccggtcaaa cgtgaggaaa cagcgccatt 16441 tcatgaaaat gaaatcacag aagatatcaa tttgttcgat atactgcctc ttttcagaat 16501 taaccagggt gatggaggct actatttaga caaagcatgt gtcatttccc gtgatcttga 16561 ggaccctgac aacttcggca aacaaaatgt cggcatttac agaatgcaag tcaaaggaaa 16621 agaccgcctt ggcattcagc ctgtcccgca gcacgatatt gcaatccatc tgcgccaagc 16681 tgaagaacgc ggcatcaacc ttccggtcac tattgcgctc ggctgtgagc cggtcattac 16741 aacggcggca tcgactccgc ttctctatga tcaatcagaa tacgaaatgg caggtgcgat 16801 tcaaggcgaa ccatatcgca tcgtcaaatc aaagctgtct gatcttgatg ttccgtgggg 16861 cgctgaagtg gtgcttgaag gtgagattat tgccggagag cgcgaatatg aagggccgtt 16921 cggtgaattc acaggccatt attccggcgg acgcagcatg ccgattatca aaattaaacg 16981 cgtctatcac agaaacaatc cgatctttga acatttatac ttaggcatgc cttggacaga 17041 atgcgattac atgatcggca ttaacacatg cgtgccgctt tatcagcagt taaaagaagc 17101 gtatccgaac gaaattgtgg cagtgaacgc catgtacaca cacggtttaa tcgcgattgt 17161 ttccacaaaa acccgctatg gcggatttgc gaaagcggtc ggcatgcgcg cactcacaac 17221 gccgcacgga ctcggctact gcaaaatggt catagtcgtt gatgaggatg tcgatccatt 17281 caaccttccg caggtcatgt gggcgctttc gaccaaaatg catccgaaac atgatgcggt 17341 catcattccg gacttatctg tcctgccgct tgatccggga tccaatccat caggaatcac 17401 tcacaaaatg attctcgacg ccactacacc ggttgcgccg gaaacaagag gccattattc 17461 acagccgctt gattctccgc taacaacgaa agaatgggaa caaaaactaa tggacttaat 17521 gaataaataa ggaaaggatg ttcgaaatgc atacatgtcc tcgatgcgac tcaaaaaagg 17581 gagaagtcat gagcaaatcg cctgtagaag gcgcatggga agtttatcag tgccaaacat 17641 gcttttttac atggagatcc tgtgaaccgg aaagcattac aaatcccgaa aaatacaatc 17701 cagcgtttaa aattgatcca aaggaaacag aaacagcaat tgaagttccg gcggtgccgg 17761 aacgaaaggc ttgatccgcg tgaactgtat gtcagaccgt ctctttgagc tgcttgacgg 17821 gagctgcctg aatgagaagc agcatgaggc cttcgttctg caaacagtat cagaggatgg 17881 ctggccgcat gccgctatga tcagtgcagg tgaaatcatc gcgctgagcc gaactgatat 17941 ccgaatcgct ctgtggaaaa acacaatgac ttcggccaac atccttcgca caggaaaagc 18001 acagttcacg gcgtggtgga agggagcggc ctattatgta aagcttgaat gcgcgccttt 18061 accgcctttg aaagatgccg aatatgaaag agaccgtttt tcctgccgca tcgtttcagt 18121 gaaagaggac gttgcgaaat acgctgattt gacttcaggt gtccgtatac agcttcacag 18181 ccctgaagag gtgctgagca gatggaaaaa gaccctggaa gatttaaaac ggtaatatcg 18241 atagcctgac gccatgcgtc aggctttttt tatataatga aaacaaaagg gggcgtgaga 18301 aatggaacgt gcggggatct gtcactcgga cggctttgat ttagcttatc gaattgaggg 18361 cgagggcgca cccatccttg tgatcgggag tgcggtttac tatccgcgcc ttttttcctc 18421 agatatcaaa cagaaatatc aatgggtctt tgtcgaccat aggggatttg ctaagcctaa 18481 gcgggagctt cgtgcggagg attcgaggct tgatgctgtc ttggctgata tcgaaaggat 18541 gagaacattt cttcagcttg aggatgttac tatcctggga cattccgggc acgcttttat 18601 ggctttagag tatgccagga catatcccaa acaagttcgg aaggtggcgc tctttaatac 18661 tgcgcctgat aacagtgaag aaagacagcg aaaaagcgaa tcatttttca tggaaacagc 18721 cagtcttgag agaaagaaac gctttgaaaa agacatcgag aatttgccgc aggacatcga 18781 caaagatcct gaaaggcgct ttgtgcacat gtgtattcgc gctgaagcga aaagctttta 18841 tcaagagcgg ccgcatgctg ctgccttatg ggacggtgta ttcacgaata tgccgatcat 18901 tgatgaatta tggggcaata catttgcccg gattgatctt cttcagcggt tagctgatgt 18961 tcgtatgccg gtgtatatcg gattagggag atatgattat ttggttgcgc ccgtttcgct 19021 atgggatgct gttgacggtt tatatcccca tgttgataag gttatttttg aaaagagcgg 19081 ccatcagccg atgctggaag aaccggaagc ctttgatcaa agcttcagga aatggcttga 19141 tcaataaaaa acagcccgca gatcaacatc cgcgggctgt ttctgattat aagacccctt 19201 tcatcgcgcg tttgatcacc ggcgagagca gcaggagaat gccgccaaga acgatagaaa 19261 tcaaaccgat ggtgccgaag tacattgttt caggaatttt atcaaacaat ccggctactt 19321 gggcattgat cgcttgggct gctgcgttcg tcagaaacca catactcatt gtctgtgcag 19381 agaaggcagc tggtgccagt ttcgttgtca cggataaacc gactggagac aggcacagct 19441 ctccaagcac gacaagcagg aagctgagaa cgagccaaag cgggcttacg agtgcttctt 19501 ttccttgcat agcagggaat accataatga taaatgacaa tccggctaaa ataattccga 19561 ttgagaattt aactggtgta gacggctgac gtttgccaag cttcatccag agccatgcga 19621 atattggcgc aaaaatgaca acaaacaatg gatttaatga ttggaaccat gatgactgaa 19681 gttcgaatcc gcccaatgaa agtcttatgc gttcatcagc gtataccgca agaatggtcg 19741 ctccctgttc ctgaatggcc cagaacatga cagcaccgat aaacaaagga acgtaagcgg 19801 caagacggga tttttctgtt ttgtccgctt ttttgcttgt aaacatgatg atgaaataaa 19861 tcacaggaat caaaataccg agaatactta caaggtcaat gaaacgtttg atcgtcagca 19921 cgcctgtttg tacagagata atcactgcga tcgccacaat gataacaccg attccggtgc 19981 caattgcaga ttttttagac agcggattcg gcacattgga acctgcaagc ccgaggtttt 20041 tctttcttgt caaagcaaat acgataagtc cgagaagcat tccgaccgcg gcagctccga 20101 atccgagatg atagttgtac ttctgtccga gtgttccgac aattaacggc gcgagtaaac 20161 caccgaggtt aatccccatg tagaaaatac tgaaacctga gtcgcggcgc gggtcttctt 20221 tcgtgtaaag atccccaact acgcttgaaa cgtttggttt taataagcct gttccgacaa 20281 tgataagcac catactgata tagaatgcta tcgaactgcc cggataggcg agtgcaatgt 20341 ggccgaacat aatgaatatg ccgccgtaaa acacggtgtt tgcggtaccg aatacccggt 20401 cagcgagcca tccgccaata atggtggaca tgtatacgag tgatccgtaa atcgacataa 20461 tggcaaccgc agtgcccttg tcaaagccga gccctccgtt taccgtctct gtatacaaat 20521 agtaaagtaa gattgctctc attccatagt aagagaaacg ctcccaaaat tcggtgaaaa 20581 atagtgtaaa tagtcctcgc gggtgaccaa agaacccttt ttgcgggacg cttttaatga 20641 tactttcgtt atcaatcgaa gccatgtcag ccaaaccctt tctaaaaaaa gtgtattata 20701 aaaatcatat tcttatataa tacttgtgtc aatataattt atactcattt caaatagttc 20761 catattggaa aaattataaa tacctaaaaa tagtgatttc ctcctaattt ttaaactttt 20821 tatcgtgaga ttttcttaca caactattcc tttatatttt tttaataaaa ttttagagaa 20881 atgtacaagc agatcgggcc tttgtgagta acatgatagt aatcatagag aaggaggctc 20941 gcaattggct gaattcatat taaatgcagc ggatttcggt gttcctagag atggtaaaac 21001 ggattcgaca gaacggatta atcagtgcct cagtacagct gtttcgaaag gctatcatac 21061 tgtctggttt ccaaagggaa catatttaat agacgcaacg cttggcggag atcttaatca 21121 gaggtttcga aacgcgggga tcattgttcc cggcaacctt gagattatga tggaccccga 21181 atgtatcatg aaagtgatac cgaatagttc gtggggttat tccgcatttt atgtaggcaa 21241 gcaagagaat ataactattt ccggaggaca aattatcggc gaacgggatg agcatacgta 21301 tgcctcggcg gggataaggt caacccatga atggggcttt ggcatatgta ttgaaggatg 21361 ctcgaatgtt gtcattgatg atgtgaaaat ttccgatttt accggcgatg ggatcatagt 21421 cagcccaagg ggattaaaga ccaatcaaga ttatcgaacg tcagagcaaa ttatcatccg 21481 ccgctgtgag gttcggcggt cgaggagaaa taacatttcc attaccggat gtgacatggt 21541 cacggtggag gaatgcttga ttgaagatgc cggaacgggg aatggaacag cgccgaaatt 21601 cggaattgac attgaaggat atggcgaagg tgacgttgat tatgaggaac cgattaatgt 21661 atcaattcgc aataaccact ttgttggaaa cgtttcaagt tctgtgacca attttaacgg 21721 gtatggcatt ttaatagaag gaaatcactc agacaataca atcagctacg gatatgggac 21781 gcaaacagtg atcaagggca atattctgag acgccctgaa gacgcggcgg ctgcgccaag 21841 agtcgggata accggactcg gtgtatcaca aggaaaagag accagtgatg cagtgatcgc 21901 tggcaacctc attaccggat tttcaactgg aattgatgtc aggggaaaga gcgttcttgt 21961 gacgaacaac aaaatcagca actttgaaaa cacagggata ttggtttatc agtcctccga 22021 cgtaaaggta gacggaaacc aaattcaaaa cggactgtct gaaacaaggc gcagcatcgg 22081 tcttcgcgca gtgctgtcag atgacatcgc atttctgaat aactgtctca ttcaagtcgt 22141 tgacggtgtg aacgtttccg gcggaaatat gatcattaaa gataatctcc tgagaaaatt 22201 cagccggggc atttggattg ctcaagggaa cgcggtgatt gaagggaata cactgaatcc 22261 tgacgcgttt gaagcagtgc cggaatcata ttctgtttcc gtcacaaaca atgccggcgc 22321 catcatcaaa aacaatacat ttaaagagtt caaaaattac cccatttatt gctccacaag 22381 tgcaaaaacc tcaattatcg gcaaccactt agagcgatcc ccgcttttgg tcaccatcta 22441 tatcagcgca ggtgtgcatg agatttttga taataccatt tcagtcaaca gaacagccgg 22501 gaatccgatt gtgatttatc tcaatggctc tgcaggctct atcatctctg gaaacaccat 22561 caataacctc tccgcgggca ctgcgacagc tattcaaaca aacacgtcaa ccaattccaa 22621 aatcatcggc aaccgcattt ttaaagggac catcaacaaa cacagcagtg atacaataga 22681 cggcaatatg attgtctgaa aaaagcgccc ccctttaggg gttctttttt tttcgattta 22741 tagatcacgt acatttctct cacaagtact aacacaaaaa ataaaagcac gacccattcc 22801 gcaaatgttg tcatcttaaa gctggacata ttgttataaa cggcttttgt taaactgaac 22861 ccttgaagca tgtccatcaa cacagaaata gctaataaac aaattaatat gaatccggtc 22921 acgcccaata tcttcatgct tcatcatcct ccgcttttag tgtctatctt tggcggagaa 22981 gttataccgc atctaaccct aatgcataat ctcaatttta aaaggaagaa tatgagaaaa 23041 cgacaaggaa aggtatttgt gtatgccttt attttctaag cgaaagaaca ataccgattc 23101 aaaagacaag cagaatacag acgaaaggaa tcaggaacag cagcaagaaa aagaaaggcc 23161 ggttctcatt tctccaagtt tagcaaagaa tatagcggaa acgaaaaagg aagtcggaag 23221 cagctctgac gtcatcattc gcgagattaa aatcggggag caggatcatg tccacctagc 23281 tgttatctat atttctgggc tggtcgataa taacacgatc catgagtcgt taattgaccc 23341 attggtacag gatgagtcta tccagaatac tcatgcgatc cagcaaattc ttgaaaaaac 23401 gctcccgctg ggcggggtga aagcggaaaa gagctgggac aagctttttt ccgagttaat 23461 gcttggcaat gcgctcattt ttgctgatgg ccatgatgaa gctttgattt gcagcactca 23521 agggggagag cagcgctcca tccaagagcc gagcacccag gtgtcattcc gcggcccgcg 23581 ccaagggttt acagagtctc tgcaaaccaa tatttccatg atccggcgat acattaaaaa 23641 tccgaattta tgggttgaaa aaatgaaaaa aggttctgtt acgaatacgg atatcgctct 23701 catgtacatt caaggaatat gtgatgaaaa ggtgctgaag gaagtgaaac agcgcctgga 23761 aaaaatagat attgacagta ttttggaatc tggatatatt gagcagctga ttgaagatga 23821 aacctttacg acgtttccga ctatgtatca tacagaacgc cctgatgttg tagcgggtaa 23881 tctgttagaa ggaagattcg cgattattgt ggacggaaca ccgtttgtgc ttattgcccc 23941 agccttattt gtccagtttt ttcagtctgt tgaggattat tattcgcgtt ttgacattgc 24001 gacaagcata agaattcttc gtgttttagt ctttttcatt tcgcttgtgg caccagctgt 24061 atacgtggca gccacgacgt ttcatcaaga aatgataccg actcagctgt tagtggtcat 24121 tgcggcccag cgggaaattg tcccgtttcc ggctgttgtg gaggcgctga cgatggaggt 24181 tgcttttgag attctgaggg aagcgggagt caggctgccc cgggttgtcg gctcggcagt 24241 gtcaatcgta ggcgcgctcg taatcggcca ggctgccgta caggctggta tcgtctctcc 24301 ggcaatggtg attatcgtgg cactcaccgc gattgcgagc ttcgcaacac cggcgtttgc 24361 aatggcgatt tcagcccggc ttattcggtt tatctttatt attgcctcag ctgttatggg 24421 tttttacggg ctgattttag ggatcattat gatgtttgtc cacttatgca gtcttcgttc 24481 attcggcgtt ccatatatgt cgccgcttgc acctttttct tcacaaggcg taaaggacgc 24541 gcttttccgg gttccgtggt gggccgatga aaaaaggccg gaatcggtca gcaaggaaga 24601 taaggtgcgg caggggaaag atcaacgccc agagccggcc gcttcacgag gaatggtgaa 24661 caaagatttg gaagaagggg atcagaatgg tacgtaaatg tctattagcc gttctcatgc 24721 ttttgagcgt cattgtgctg cccggctgct gggataagcg ggagctgacg gatcttgcga 24781 ttatctcggc gattggcatc gatcggacaa acgacagcaa ctacgtgctg catcttcaaa 24841 ttatcaatcc aggaaatgtt gccggcggcc ttcagggagg cggtgctgga gacaggccgc 24901 ctgtatctgt ctattcgatt gaaggtaaca atataacgga agcactcaga aaagcctcca 24961 tgaaggtatc acggcggctt tattttgccc ataccaatct agtcgtgatc aatgaaaagc 25021 tggcaaaaga agaaggtttg gattttgtat tagataatct tgaccgggac acagaattca 25081 ggacaacagc aacattcgtc gttgcccata aaacaaaagc agaaaatatt gtgaaaatct 25141 tgacgccgat tgataaaatt ccgtcaaata aagtcaataa aacactcgat ttcacggagg 25201 cacaatacgg gcgggtggtc aaaatcaata ttcaggacgt tttgaaaaca cttgccgcca 25261 acactatggc accggtcatc cccggatata tgatgattgg tgacgataaa aa //