GCA_003434135.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaDAKFFJCC_5 (original name was: gnl|Prokka|DAKFFJCC_5)

Region	Type	From	To	Most similar known cluster		Similarity
Region 5.1	cyclic-lactone-autoinducer,lanthipeptide-class-ii	73,954	97,206

gnlProkkaDAKFFJCC_12 (original name was: gnl|Prokka|DAKFFJCC_12)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	ranthipeptide	95,278	116,943

gnlProkkaDAKFFJCC_21 (original name was: gnl|Prokka|DAKFFJCC_21)

Region	Type	From	To	Most similar known cluster		Similarity
Region 21.1	cyclic-lactone-autoinducer	1	13,827

gnlProkkaDAKFFJCC_26 (original name was: gnl|Prokka|DAKFFJCC_26)

Region	Type	From	To	Most similar known cluster		Similarity
Region 26.1	cyclic-lactone-autoinducer	5,396	16,420

gnlProkkaDAKFFJCC_27 (original name was: gnl|Prokka|DAKFFJCC_27)

Region	Type	From	To	Most similar known cluster		Similarity
Region 27.1	cyclic-lactone-autoinducer	1	13,139

Region	Type	From	To	Similarity
Region 5.1	cyclic-lactone-autoinducer,lanthipeptide-class-ii	73,954	97,206
Region 12.1	ranthipeptide	95,278	116,943
Region 21.1	cyclic-lactone-autoinducer	1	13,827
Region 26.1	cyclic-lactone-autoinducer	5,396	16,420
Region 27.1	cyclic-lactone-autoinducer	1	13,139

Compact view

gnlProkkaDAKFFJCC_5 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii

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Location: 73,954 - 97,206 nt. (total: 23,253 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg5_85

allorf_95404_95613

Leader:

MNSNEKHEEIDCAELERLAAFGG

Core:

SDDSQINPCSDVATTTAIIGAISSVVSAISTISAAMSKVPACKPKG

Core with dehydrations:

DhaDDDhaQINPCysDhaDVADhbDhbDhbAIIGAIDhaDhaVVDhaAIDhaDhbIDhaAAMDhaKVPACysKPKG

MIBiG 3.1 matches for allorf_95404_95613

19.6% BGC0001229 (SBI_06989): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

10

SDVATTTAIIGAISSVVSAISTISAAMSKVPACKPK

45

+D A T I+G ++ +SAA C +

1

TDPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSR

36

15.2% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

15

TTAIIGAISSVVSAISTISAAMSKVPACKP

44

T II +SS + C+P

7

TVKIIFRVSSHFGGNGGFGLFCTLSKECQP

36

antiSMASH-DB 4.0 matches for allorf_95404_95613

100.0% NZ_JAQCXO010000012.1and 1 other:

NZ_QVFB01000013.1 Lanthipeptides: DW855_RS14250_lanthipeptide

Lanthipeptides: PGY55_RS14505_lanthipeptide

1

SDDSQINPCSDVATTTAIIGAISSVVSAISTISAAMSKVPACKPKG

46

SDDSQINPCSDVATTTAIIGAISSVVSAISTISAAMSKVPACKPKG

1

SDDSQINPCSDVATTTAIIGAISSVVSAISTISAAMSKVPACKPKG

46

93.5% NZ_QVFA01000004.1: Lanthipeptides: DW882_RS14120_lanthipeptide

1

SDDSQINPCSDVATTTAIIGAISSVVSAISTISAAMSKVPACKPKG

46

SDDSQINPCSDVATTTAII AISSVVSAIS ISAAM+KVPACKPKG

1

SDDSQINPCSDVATTTAIISAISSVVSAISNISAAMTKVPACKPKG

46

26.1% NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide

Lanthipeptides: OCU69_RS05005_lanthipeptide

16

TAIIGAISSVVSAISTISAAMSKVPACKPK

45

T I+ AIS+ V++ + ISA + AC K

2

TPIVSAISATVASATAISALFTVTSACTTK

31

with 3 more sequence matches

23.9% NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

20

GAISSVVSAISTISAAMSKVPACKPK

45

G + VSAIST+SA AC +

4

GCAWAAVSAISTVSALFQITTACTTR

29

21.7% NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

15

TTAIIGAISSVVSAISTISAAMSKVPAC

42

TT ++ AIS+ V++ + +SA + AC

1

TTPVVSAISATVASATAVSALFTVTSAC

28

17.4% NZ_JACSJU010000005.1: Lanthipeptides: KNO78_RS14610_lanthipeptide

31

TISAAMSKVPACKP

44

T S AMSK+ C P

18

TFSVAMSKLFKCGP

31

allorf_96380_96529

Leader:

MEKICNKTGFIHNNMSPNTGLPASGDISERMIAA

Core:

YSHHICKLTISQSLL

Core with dehydrations:

YDhaHHICysKLDhbIDhaQDhaLL

antiSMASH-DB 4.0 matches for allorf_96380_96529

100.0% NZ_JAQCXO010000012.1and 1 other:

NZ_QVFB01000013.1 Lanthipeptides: allorf_96380_96529_lanthipeptide

Lanthipeptides: allorf_071718_071867_lanthipeptide

1

YSHHICKLTISQSLL

15

YSHHICKLTISQSLL

1

YSHHICKLTISQSLL

15

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_95404_95613 - Class II

Cleavage pHMM score: -2.80

RODEO score: 0

Monoisotopic mass: 4257.3 Da

Molecular weight: 4259.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4277.8 Da N = 1; 4295.9 Da N = 2; 4313.9 Da N = 3; 4331.9 Da N = 4; 4349.9 Da N = 5; 4367.9 Da N = 6; 4386.0 Da N = 7; 4404.0 Da N = 8; 4422.0 Da N = 9; 4440.0 Da N = 10; 4458.0 Da N = 11

allorf_96380_96529 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 1669.9 Da

Molecular weight: 1671.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1689.0 Da N = 1; 1707.0 Da N = 2; 1725.0 Da N = 3

gnlProkkaDAKFFJCC_12 - Region 1 - ranthipeptide

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Location: 95,278 - 116,943 nt. (total: 21,666 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDAKFFJCC_21 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 13,827 nt. (total: 13,827 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDAKFFJCC_26 - Region 1 - cyclic-lactone-autoinducer

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Location: 5,396 - 16,420 nt. (total: 11,025 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaDAKFFJCC_27 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 13,139 nt. (total: 13,139 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.