LOCUS       gnlProkkaOCEDIECO_28   12886 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OCEDIECO_28.
ACCESSION   gnlProkkaOCEDIECO_28
VERSION     gnlProkkaOCEDIECO_28
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 01:19:13
            Original ID  :: gnl|Prokka|OCEDIECO_28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 355143
            Orig. end    :: 368029
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12886
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9286]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9286
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12886
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12886
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(514..1317)
                     /locus_tag="ctg26_286"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
     CDS             complement(1367..1714)
                     /locus_tag="ctg26_287"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(1855..2193)
                     /locus_tag="ctg26_288"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDKSE"
     CDS             2715..3239
                     /locus_tag="ctg26_289"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             3243..3728
                     /locus_tag="ctg26_290"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             3725..5008
                     /locus_tag="ctg26_291"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     3.8e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_292"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.8e-14, bitscore:
                     48.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             5740..7041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_293"
                     /sec_met_domain="CTP_transf_like (E-value: 3.8e-11,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.8e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             7053..8189
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_294"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.5e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8186..9286
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg26_295_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_295"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-30, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        8276..9064
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_295_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg26_295_Aminotran_5.1"
                     /locus_tag="ctg26_295"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9306..10799
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_296"
                     /sec_met_domain="Polysacc_synt (E-value: 1.2e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPITVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             10803..11948
                     /locus_tag="ctg26_297"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             11945..12814
                     /locus_tag="ctg26_298"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             12822..12884
                     /locus_tag="ctg26_299"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLL"
ORIGIN
        1 caaactggtc gattttgttg gcaggaagaa agaccgcatt gtgtatttgc aatgtgcacc
       61 tctgctcaat gatgattttc aagtggagca aatgtacaac acgctggaga tgatacaaga
      121 caattatgaa aagtgggtcg tttctatgga cgataccaca ttgccctcca aagaagggat
      181 tcgtcacata caagtctggc aactgcctga aatactatag tctgacaatc ttttttgatt
      241 gctttgatgt ccggatgatg ccgtttacga agttaacatc ttgttgttta cgaagttaat
      301 atcataattt tacgaagtta aaatcgtatc ttcgggaagt taacttcctg aagtcacgat
      361 tttaacttcg tattagtgct ttttgaatcg cttttcaatc ccttgagaat cagtgctcgt
      421 ttccggagga aaacagctgc gttctttaat tgattgcaag caaatagcat tttccagaat
      481 ataaaatgta ctgtttgtca gaaaagttct tttttaggtt ccgcttcttt tctttgcccg
      541 gttcaacgct gcgatcatgt attttccttt tgctccgatg ttactccagt tcgtgctgca
      601 aatcagtttc catacagggg ttccttttct cccgtaatcc gacagtcgca ggattgcttc
      661 gatctctttt tcgtctgtta ttccgaatcg ttccaggttt cccattaatc ccacgtagtt
      721 gtgtgtcatt gtattaaatg cgtatccggg catactgacc ggcgtagcat tgacttcctc
      781 ttccttcccc cttgggggag ctgagggggg aaattctcta ctttgcttta ctttactttg
      841 ttcggtattg catgcatttt ttgcatcaga gcctgcatcc tgctctacat tttgcgtgca
      901 gacggtcttt tcttcattac atgtctcttt cggttttatc agtagataag gcatggctgt
      961 ccagttcctc tttcttcgct tggttgcctc tatccatact ttttgtattg cttcagaggt
     1021 cagtacttta tgttccgcat agcttcccct gtctatcatt cctttctcga tcattatctc
     1081 gataatcccc tgcacctctt ctgcgtctgc ctcttttccc gtcttgttgg cgaaaataag
     1141 gcattgttcc tcaccccacg gaatataata tccttcttta tatattttgc ataggagttt
     1201 cagtacaatc gcgagtcctt tcatgccata ttttgcttct attacctcca ttgcgttctc
     1261 ttccataaaa ttcacagcta tcggaaagta atttattcca tcgtatgttg ttgccataat
     1321 tgttaagttg ttatgttact gattaattgg tcactgaaag attctcctat acgatcgctc
     1381 tccattccat gaaattctct attttgaagg tcatccacct ttgttgctcc acatcccggt
     1441 agaccactgt gttttttatt tccatcggat catactgctt tccgaaatct ttttcgtatc
     1501 ccaccaatgt tcctttcacc agtttgaatg ttccgtcctg tttcatataa gctacggctg
     1561 catgtccata ttgcatatat tctatgaggg cttccagtcg ttctgccatc cattcggagc
     1621 actgttctgt gtagtccttt tcgagcatga tttgtctttt ccattttcct ttcatcattt
     1681 cgtttttcga tactgctttc ctgttctttt tcataattga tttttttaag tttattaatg
     1741 agttattgtc gggcttttat ttttacccgt ggcaaagtac ggtaataagt tttgaataga
     1801 ctaatcctgt aaaagtactt tagaaaggga cttttacagg attttaacaa tcggttattc
     1861 gcttttatct cgctttttcc ggaatgctct ggcatatttt ttcagctctg atagaaaaga
     1921 acgtttatta ggctctgtag caatgccttt gcgctgatat tcaaaggtga gatattcttt
     1981 tattgtttcc tgtagttctt caatgggtct gttttccatg ctgttgattc cgcctttgat
     2041 aaagctttcg gtaagtgcct ccattagctt tcctttgcct tttgtgatgc gtagtggttc
     2101 tctaaccttt tgattgaggc tgaattgcaa gtcggcttta cccgcaaaga ttacttttcc
     2161 atttacttcg atggttacta agttatcatt caatgagata actacttttt ttcttccata
     2221 atgttagtta ttaaatgaat ttatgaaagg acaaagtttg tataaaaaaa tataaatata
     2281 aaagaatacc ggagtttttt tagtttaaag ggagaatctt gaagtgtaag gatcttgtta
     2341 ttagttattt atcttaagat ataggcgttg tttcaaaaaa cgttcgtttg attgaacaaa
     2401 ggtaaggagt ctgttttaat gtacaaaata tttagtggat aaaattttat caaagatttt
     2461 atattgttga ttttcaaaca catatagagc aaaaaaagtt ctctgctcag ctactttaca
     2521 atattcattt tttcatcgaa aaaaactcaa aaaatgctgt ttcaaaagac gaacgttttt
     2581 tgaaacacat tcgttcgttc tcaacttcta aaaatgtttc gtaaaatttg acggtttgaa
     2641 agagaaaaga tgtctcgttc aaaccgcgaa gcgcacccga aacaaaggaa aatttcccca
     2701 agtataaatc gtaaatgtct gaacaacaga agtattggtt tgccgcccgt acccgagata
     2761 aacaagagtt tgctattcgt gactctcttg aaaaattgaa gactgaactt gatctcaatt
     2821 actatcttcc cactcagttt gtcatccggc agttgaaata tcgtcgaaaa cgggtggaag
     2881 tccctgttat taagaatctt atcttcatcc aagctaccaa gcaagatgct tgtgatattt
     2941 ctaataaata caatatccag cttttttata tgaaagacct gcttaccagg gccatgctga
     3001 tagttcctga taaacagatg caggacttca tatttgtcat ggatttagat ccgaatggcg
     3061 tcagtttcga taatgaccat ttatctgttg gtagcagggt tcaggtagtt aaaggtgatt
     3121 tctgtggtgt cgagggcgaa cttgccagcg aggccaacaa aacttatgtt gttattcgta
     3181 ttgccggtgt attgagcgcc agcgtcaaag ttcctaaaag ttatttacgt gtcatttaag
     3241 ttatgaatac actcacttct caaattgaac aattacagag tctcgcgcac gagttactct
     3301 atttaggtgt ggatggtgct cctatttata ccgatcattt ccgtcagttg aacaaagaag
     3361 ttttagaaca atccgatgcg ttgtatcctc agcgtggtgc tactcccgaa gaggaagcaa
     3421 acatctgtct ggcattattg atgggttaca atgcaaccat ctataatcag ggtgacaagg
     3481 aggagaaaaa gcaagttgtt ctcaatcgtt gttgggacgt gcttgaccaa cttcctgcta
     3541 ctttattgaa atgccagttg ttgacttatt gttatggtga ggtgtttgaa gaggagttgg
     3601 cgaaagaggc gcatactatc atagaaagtt ggagcaatcg agaactttta aaagctgaaa
     3661 aagaaatagc tgaaagtttg aataatttgg aagctaatcc ttatccgtac agcgaactac
     3721 acgaatgatt cgttcctttc tttcccgttc tcccctttac gttttggctc tctatgccag
     3781 cgttttgatt tttctggttt atacttgtgc ctatgcctac cgtaagccat ttaccgcagc
     3841 catttatgaa ggtgagattc tttggggatt cgatgtcaaa atcctgtatg tcctttctga
     3901 gattatcggc tacgcccttt ccaagttcat cggtgttcgt attttgcctt cgatgaaagc
     3961 gggtcaccgc atctattata taatagggct gcttactttt tccgaagttg ctttgttggg
     4021 ttttgcactt cttccggttc ctttgaaggt gtgttctatt tttctgagcg gtcttcccct
     4081 gggtatgatc tggggtgtca tttttagcta tatcgaaggg cgtcgtatca gtgaaatatt
     4141 gaatgtcggg ctgagcgttg ctttgatagt ctcttccggt ttggtgaaaa ccttgggaca
     4201 attcgtgatg gataatttgc atgtgtcgga atattggatg ccttttacca ccggtttgtt
     4261 ggtataccct gttatgttgc tttgcagctg gcttctcaat cagattccgg ctcccaatga
     4321 gcaagatatc atacagcgta ccaaacgtgc tccgatggat ggtaaagaca ggcgtaagtt
     4381 tttgaggcaa ttcttttggg gaatctgcat gctggttgtt ttttacggtg ccctgaccgt
     4441 gttccgtgag cttcgtgact ctttcgctgc cgatatttgg aaggagctcc atattgaggg
     4501 tgcaatgatc tttactcaga cagaggttcc cattgccgtt tttgtccttg tactgatgtt
     4561 cctgattgtg tttgtccgta ataaccgttt ggctcttaat atcatttatt gcatcgccgt
     4621 cacaggcggt tccttaatgg ttttttccac attgctttat gtgtacggtt ttctttctcc
     4681 tatttggtgg atgattcttt ccggtcttgg tctgtatatg gggtatattc ctttcactta
     4741 cctgatagaa cgtctgattg cttcccttag ggtggttagt acggctgttt ttattattta
     4801 tttggccgat tctttcggct atctgggcac tacgggtgtg tttatggtca agaacttcgt
     4861 ttctgctgac atttcctgga ctgtcatgct gatgcgtact gccctttttt caggatttgt
     4921 ttctgtcctg tcgatttttg cgatttactg ttatttcaag caacaattga attcacttat
     4981 attaattccc tctgaaattc atgattaaaa cagcaatgat catggctgcc ggtcttggta
     5041 cccgcttcgg gcattatacc gagcttgtgc ccaaaggttt tgtggaggtt ggtggaaaac
     5101 ctatgattat ccgctctatc gaaacccttc tttcctgcgg tatcgaacgt atcatcctcg
     5161 gtacgggtta taaaaaagag gcttatgaag cccttcaggc ggatttcccc cagatagaga
     5221 cctgtttcag tccccgttat gccgatacta acagtatgta cactctgtac aatacgcgtg
     5281 acgtgatagg cgatgacagt ttcctgctgc ttgaatcgga ccttgttttt gaacgcaagg
     5341 ccatcctctc gctgctggat gacgaattcc cggatgtgat gcttgtctct tctctgacca
     5401 agttccagga tcagtattat gtggaatatg accgcaatca catccttact tcctgttcgg
     5461 tagacaagga cgcccttgag gcaaaaggcg agctggtcgg tatccataaa ctttccaata
     5521 ctttctaccg ccggatgtgc gccgattatg cgaccatcct ggagtcccag cctaaactgg
     5581 gttacgaata cgaactgctc cgcatgtccc gttccgtttc ccctgtccgt gtgctcaggg
     5641 tggagggtct taaatggtat gaaatcgatg atgaagccga cctttcgtat gccgaggagc
     5701 acatcatccg ctattgttaa aaacaaatct tttccatata tgaacaagaa aatttatgtc
     5761 ggtatgaccg cggatatcat gcatccgggg ctgatccata ttattcatga agctactaaa
     5821 tacggtgatg tcatcgtcgg tctgctgacg gacaaggcca tcgccgaaca caaacgcctc
     5881 ccttacctta cctatgatca gcgtaaggag gttgttgaga atatcaaggg ggtttttgag
     5941 gttgttcccc aggaggactg gagctatgtt ccgaatctgg aaaaactcaa gcctgactat
     6001 atcatccacg gcgacgactg gaaaacgggc ccgttgcgcg aggtgcgcga acaggttttt
     6061 gaggtgatga acgcccaggg gggcaaggta atcgagatcc cttatacccg gggcatcaac
     6121 tcctcctcgc tcgacaagga tatcaaggcg atcgggacta cccctgacgt acgtcttaag
     6181 tccctccgcc gcctgatcca ggccaagcct gtggtccgta tcctggaggc tcacgacggt
     6241 ctttgcggtc tgattattga gaatcttgaa gtccagaagg gggataagcg cgaggtcttt
     6301 gacggcatgt ggtccagcag cctgaccgac tccacgagta agggtaaacc ggatattgaa
     6361 gcggtcgacc ttaccacccg tttacaggac ctgaacaata tccttgaatg taccaccaag
     6421 cctattattt ttgatggaga cacgggtggc aagatcgaac actttgtctt tactgtgcgc
     6481 actctggaac gtcatggcat ttctgcagta atcattgaag ataaagtcgg tctgaagaag
     6541 aattcccttt ttggtactga cgctatccag actcaggata gtatcgaggg gttctgcgat
     6601 aagatcagag cagggaagaa tgcccaggtc accggtgact ttatgatcat tgcgcgtatc
     6661 gaaagcctta ttgccggcaa acccatgagt gacgccctcg aacgtgctta tgcctatgta
     6721 caggcgggtg cggacggcat catgatccac agcaaggata agtcgggtga ggatatccgt
     6781 gagttctgcc ggactttccg caaagaatac gcccatgttc ccattgtcgt tgttccgacg
     6841 acttatgacc atgtgcacga atccgaactt cacgaatggg gtgccaacgt agtcatttac
     6901 gccaaccacc ttctccgtgc cgcttacccg gccatgatga acgtggccag gaccatcctt
     6961 gaaaacgagc gcgccgagga ggtccgtccg ctttgtatgc ctatcaagga aattctggaa
     7021 ttgattccgg gcactaaata aatcagacgg ttatggtaag tgtagaaaag atatacgata
     7081 cgttccttca tcacggtgtt gacttcttta cgggtgttcc cgattccctt ttgaagaata
     7141 tttgcgccta tatcacggat catgctccgc gtggtaagca tatcatcgcc gccaatgaag
     7201 gttccgcggt gggcattgcc tgcggttatt atatggcttc tggcaacgtt cctttggttt
     7261 atatgcagaa ctccggtctg ggaaatacgg tgaatcccct cttgtccctt gcggacgaga
     7321 aagtgtacag ccttcctctt cttttgctgg tcggctggcg cggtgagccc ggcacaaaag
     7381 acgaacccca gcataagaag cagggcgagg ttacccttga tcttctgaaa gccatgaaaa
     7441 ttccttttat aattctggat acggatgaag acgaggccct ggcgcagatc catgacgcgg
     7501 ttgtctcggc gaagagccgg tcgattcccc atgcgattgt catccgtaaa gatacgtttg
     7561 gaaaatataa attgcgtcag gaagccttga atgactatcc tctgtcccgc gaggaggcgc
     7621 taatgcaggt tgtcgaccac ctcggggaca atgacattgt ggtttccacc acgggcaagc
     7681 tctcccgtga gcttttcgag taccgtgaat cgaaagggca ggggcacgca agggatttcc
     7741 taactgtggg ttccatgggt cacagttctt ccattgccct ggggattgcc cttgagaagc
     7801 ctgaccgccg tgtctactgt cttgacggtg acggtgcctt tatcatgcac atgggtgctg
     7861 tcagcaatat cggcgatctt tctcccaaga attacaggca cgtccttttc aacaacggtg
     7921 cccatgaatc tgtcggcggt caacccacgc tcggtttccg tctggatatc gcctcgatag
     7981 cgaaaggttg cggttatgcg catgtactga ctgcctccga caaggaaggg ctttcgtgtg
     8041 cgcttgagaa gctgtccggc ctgtccggcc cggttcttct tgaaattaag gtccggatcg
     8101 attcacgtga tgatctgggt cgccctacga ctactccggt agagaataaa gagcatttta
     8161 tggcattttt aaaagatacg cattcatgaa tatcgaaaga aagatccttt tgaatccggg
     8221 tcccgccacc acgacggata cggtaaagct ggcgcaggtt gttcccgata tctgtccgcg
     8281 tgagaaagag tttgcgggta tgatgaaaca gttacgtgac gacctggtcc gcgttgcgca
     8341 tggagacctc tccaaacata cggccgtcct gttttgcggc tcgggtacga tcaatatcga
     8401 tatctgcctg aactctcttc ttcctgcgga taagaaagtt ctggttgtca ataacggtgc
     8461 ctatagcacc cgtgcggtgg aagtctgcga atattacggt cttccccata tcgatttgaa
     8521 gttttccgtt tacgaacttc ccgacctgtc ggtaatcgaa aagacgcttt ccgacaatcc
     8581 ggacatcgct ttggtctata ccacgcacca tgaaacgggt acgggtatct tgaaccccat
     8641 ccgtgagatc ggaaaaatag cccattcgca cggtgccgtt tttgttgtcg acaccacttc
     8701 ctccctgggt atgattcctt ttgatatcgg gaaggataat gttgactttt gtatggcttc
     8761 ggctcagaaa ggccttcagg ccatgacggg tctttccttt atcataggtg atgaatccct
     8821 gatacgtgct tcaagggatt atccgaaacg ctcctactat tgtaacctct atttacaata
     8881 cgattacttt gagaagacgg gtgagatgca ttttactcct cctgttcaaa ccgtttacgc
     8941 tgcccgtcag gctcttgatg aatattttgc agtaggtgaa gaggctaaat tcgcccgtca
     9001 caagagggtc tttgaagcca tccataaagg tttgcaagag cttggtcttc agtatgcgat
     9061 caaacgtgaa tggcagtcgg gtcttgttgt ttctgtattg tatcctgatg atcccctctg
     9121 ggattttgat aaggttcatg attactgcta tgaacgtggc tttacgatct acccgggtaa
     9181 gatttccaca acgaatacat tccggctttg tgcgttggga gagattgatg tggaggatat
     9241 tgagaggttc tttgaggtga tgagggaggc tgttttaaaa tactagagaa attgtcaatt
     9301 gggatatgaa agataaaaaa aatgtagtaa aatggaattt tgtattttat ctcttggaat
     9361 ttttgtatac aattttagtt gggattattt tggttccgtt gtatttgaaa tatattccaa
     9421 aggatttata tggtttctgg ctagctactg gtaatatatt gtctatttta actcttatca
     9481 atcctgggtt ttcagatgtg atacaacaaa aagttgcata ttgttatgga ttacatgatt
     9541 ataaaaaaat aggattatat accgtttcag gtatttgtct tacgtttgtt ttttcattaa
     9601 ttgttttgat aatcggagta gtagttaacc ttttaatagg tagtatattt acaatgcaag
     9661 ctaattattt atatgaatta aaaatagctt ttggcttaat gcttgttggt acatttttaa
     9721 ctattaatta ttattccttt tcttctatat tatatgcttt tcttagtagt aagtcaatcg
     9781 ggctaattgt acttctaggc aatagtttag gtactttaat atctatttat cttattatcc
     9841 atggatatgg tctaatagct ttgggaattg catcagttgt tcgaggaggt gtttttttgt
     9901 catgtagtgt tggctatgta atatttaaat ttcgaaaaaa gaaaataaaa attgtatttg
     9961 atttaaataa tgttaaggag atcttttctt tttctatata taatttttta ggtaaaacag
    10021 gacaaacatt gttgactaat atgaattctt tcttgactgc taagtttgtt tctcctattg
    10081 acgctgcaaa tttgagattt actcaaactg tgccggaatt tggtaaagtt ttagttttaa
    10141 gatttttata ttctgttgct cctattattc ctaatttgtt agcagctaag gggttggagt
    10201 ctattagaat aaagcttttg aatattgtgt attttttgat ttcctttatt ttcttagtat
    10261 gtattggttt ttatctattg aatgaacaat ttatatattt atggcttggt gagaacaatt
    10321 tttcagggaa aataattaat ttttttatca ttattttatt gtttttttct tctataaaca
    10381 aggtctgttt tcagtttctt tttgcattag gagatataaa gaaaagcaat aagattttat
    10441 tttaccaatc tttgttgtat ttacctatta ctgtttttac aacgaaattt tgtggaataa
    10501 ttggtttatt gttatctgga atattagtag aattattggc actattcatt ttcttctttc
    10561 ctaaaatggt tgatattctt aatatttcga aaatagatat tagaaagaaa ctttttgtgg
    10621 agttaaccaa aatatctttt gttacggtta ttacattatt aataggttct tgtgtcaagt
    10681 tctctaatcc tagttggcta cttttctttg tggaaattgt ttttattgta ttaacatttt
    10741 ttgttttgtt gtttttatgt tcaaagactt ttcgtaattt attgtctatt tgtaaataaa
    10801 agatgaagat actactagtt tttatagata tgatacgtgt tgatcattta tcattatata
    10861 atgataacat ggagaaaaca tcgttggatt tgttttttga aaatttagga ggtacaattc
    10921 taactaactg ttatacacct gcacctgata ctccaagaag tatagcttgt ttgcaaagtg
    10981 gcctattacc ctatttgaat ggctgcgata gtcgtgtcaa atggccaaga tattttatga
    11041 aacctaatat agaaactatt tttgatattg cagtagggtt aggatataaa gtaaatttgt
    11101 gtgcgactaa atctgatatt gaaacagggt tgtttaagtt taaagaaaat gaaaatatta
    11161 gtatatttac tactattgaa gattttactg atactgttca tttgtcagaa aatacattgt
    11221 ccttaattgc cattgatgat tatcattctg ccattgatga ttatggagga acctcattgg
    11281 gaattaaaga agggcagaaa gtgatattat attctttaaa taattttcta actccagata
    11341 tcgtaaataa atacgactat tcgtttttct tttcagacca tgggcatgct ttgcagagtg
    11401 aaattgtcat gcaaaaaaat aaactagaac tacttagtga tggaagaact aaacttttta
    11461 tgttctatca taatattaat aataagaaaa tagtaaaaga ttctaggctt gcttctattt
    11521 tggatcttta tgcctctatt gttgatttga ttggtagtgg agattttagg caaggttttt
    11581 ccttttttag agacagtcaa agagatatac ttcatataga ggaccatgct gattttaggg
    11641 tgtctccaga gcaaattgtg agtcaatggc gagtaatttc agatgaaata gatattagga
    11701 ctaatgtatt tgaaacttta aataaaaaag gacaaataat cgatataaat gtggtaaaaa
    11761 aatatttaga tagtttttcc ccctcgtttt cttattatat gaaacagata gagattctaa
    11821 aaatgtatga gaaaatgaaa caacggaaaa cgcattattt taatggggta aagcgagcta
    11881 attggtggat ccgctgttat gttagaatta taaataggtt atatatacta ataaatagat
    11941 tgaaatgatt gtatcatctt tgcgaggagg attggggaat caaatgttta tttacgctat
    12001 ggtgaaggcc atggcattaa gaaacaatgt accattcgct tttaatttga ctactgattt
    12061 tgcaaatgat gaagtttata aaaggaaact tttattatca tattttgcat tagacttgcc
    12121 tgaaaataaa aaattaacat ttgatttttc atatgggaat tattatagaa ggctaagtcg
    12181 taatttaggt tgtcatatac ttcatccatc atatcgttat atttgcgaag agcgccctcc
    12241 ccactttgaa tcaaggttaa ttagttctaa gattacaaat gcttttctgg aaggatattg
    12301 gcagtcagaa aaatattttc ttgattataa acaagagata aaagaggact ttgtaataca
    12361 aaaaaaatta gaatacacat cgtatttgga attggaagaa ataaaattgc tagataagaa
    12421 tgccataatg attggggtta gacggtatca ggaaagtgat gtagctcctg gtggagtgtt
    12481 agaagatgat tactataaat gtgctatgga tattatggca tcaaaagtta cttctcctgt
    12541 tttcttttgt ttttcacaag atttagaatg ggttgaaaaa catctagcgg gaaaatatcc
    12601 tgttcgtttg ataagtaaaa aggaggatga tagtggtact atagatgata tgtttctaat
    12661 gatgcatttt cgtaattata taatatcgaa tagctctttt tactggtggg gagcatggct
    12721 ttcgaaatat gatgataagc tggtgattgc tccaggtaat tttataaata aggattctgt
    12781 accagaatct tggtttaaat tgaatgtaag ataaaatctt aatgaatgta ttagtaaccg
    12841 gtgctgccgg atttataggt tcgcatgttt gtaagcgtct tttgca
//
