LOCUS       gnlProkkaIOIGNEMP_2    13525 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IOIGNEMP_2.
ACCESSION   gnlProkkaIOIGNEMP_2
VERSION     gnlProkkaIOIGNEMP_2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:41:38
            Original ID  :: gnl|Prokka|IOIGNEMP_2
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 109085
            Orig. end    :: 122610
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13525
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8525]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8525
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13525
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13525
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(34..1107)
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.6e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_ctg2_113_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_113"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.5e-108,
                     bitscore: 353.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.6e-08, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     aSDomain        complement(676..1077)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_113_NAD_binding_4.1"
                     /evalue="2.60E-07"
                     /label="ctg2_113_NAD_binding_4.1"
                     /locus_tag="ctg2_113"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS_motif       complement(1024..1080)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg2_113_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg2_113"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     CDS             complement(1126..2268)
                     /locus_tag="ctg2_114"
                     /transl_table=11
                     /translation="MDKNYQVCTHCVMDTTDSNLTFDENGVCDRCREYEQHILPWWNHG
                     KGHEVELKAILEQVRISGKGKKYDCILGLSGGLDSCYMLHLAVKEWGLRPFVFHIDAGW
                     NLPVAEENIKKLCDKLNVHLHIQKLDFEELKQMQIAFFKTGHAGLDVPQDHAFIAQIDK
                     YSEELGVKYILNGYNICTEIVADPDSWFDGAGPTADKTYVKDVLKKHGNVKTKNYIYTT
                     GFKHKFVLPYIKGVKTLQLLNYVPFTKAEMLATLQREYDYQPYGQKHFEDLLTKFLEAW
                     WLPTRFGYDIRRAQLSSLIITGQMSREEALEILKNPPASDEECKKMFDEVAEKLAISKE
                     ELMSYHKLPKKYLHYKNNAWAFKIGIRLYQLLGLDKRIRK"
     CDS             complement(2277..3500)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 67.2;
                     E-value: 2.6e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_115"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.1e-19,
                     bitscore: 62.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLLQISIEVNSGSVGRIAEQIGQVALAHGWKSYITYARNHLPS
                     QSMTIKIGTKWDVYWHGIMTRLFDTHCLHSTRATRRLIQQIEEIHPDIIQLHHIHGYFL
                     NMEVLFKYLSSISTPVVWVFHDCWSMTGHCAHFDYVGCEKWLTHCETCVQKKIYPGSVL
                     IDRSFKNYELKKKLFTSMENLTIVPVSQWLGMIVKKSFLKNYPINVIQNGIDLKLFSPQ
                     SLQSVCAMRNKLGLAEQTSVLLGVASIWDKRKGLEDFVQLYNMISEDWVIVLVGLSKTQ
                     LKEIPDGIIGIERTENVTQLATLYTLASVFINPTWEDTFPTTNLESLACGTPVITYRTG
                     GSVESVSDETGYIVEKGDIKGIKRAVAEIVKRGKEVYHHICRKRAVKYYDKNERFEDYI
                     KLYDTLLK"
     CDS             complement(3512..4204)
                     /locus_tag="ctg2_116"
                     /transl_table=11
                     /translation="MNQKEKEWLASLLLVRDILDRFSIKYILDTGTLLGAVRDRAFIPW
                     DDDIDIAIIDFLFDKHLAKTIGRELYLVGFDVIITANTVHLRRCNCEINLKSYLRNGTF
                     YNSTMTKVEGSDLLYSIYNCLRRLALYRNSHSFSRQVVNFIYFIISFMNYLGGAFLQDL
                     LIAKSKPKIRKIVIPAYLLSNTKDILFYDEYFKVPIDVNEYLTLRYGKNWNIPNRNYNY
                     ITDDLSLK"
     CDS             complement(4201..4992)
                     /locus_tag="ctg2_117"
                     /transl_table=11
                     /translation="MKELSCDEFKQIQIQILSEIKIFCEKNGLNYYLAYGTLLGAVRHQ
                     GFIPWDDDIDIVMPRIDYLKFEKLFKHDRFEFLSISKDATYPYHFGKVLDKNTILVDDS
                     SSSYDIGVNIDVFPIDGLPSSEMRKRIHCHFVWFLQNIATLKLMKYVRKRGMIKNIILA
                     FLKFIFIPFPLYTVLKAINNYAMKYSMEKSSEYLLEGAYKNREVVCASIFQSKMNVVFE
                     NESYSAPVGTNSWLMQLYGNYMEMPPVERRISTHNYKVLQK"
     CDS             complement(5001..6074)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_118"
                     /sec_met_domain="Fe-ADH (E-value: 1.2e-73, bitscore: 241.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRCFLGESSIENLLLVLKEFSFSHLFLVRGRNSYETCGAKSIM
                     TAVFSELDCEVTEYFDFEENPKIEDLERGLLLLRKYSCSVIVAVGGGSVLDMAKLLRFF
                     YSYSGEPTSGKFEKEKDLLPLIVLPTTAGTGSEATHFAVLYKNKVKYSVEHNAILPDVA
                     IVYPPFTYNTPRYLTACAGFDALAQAIEAYWNAYATKESDEFAKRAIELLWPNLPLVVN
                     SPTNSMRNKVSEGAYWAGRAINITKTTAPHAFSYSFTTYYGYPHGHAVAMTFPFFWSIN
                     MDIHRIRKNISPSLYKQKIEYLKNLCNIDIGDYIEKRILLPLKLPENFNKYFILESVNR
                     QRLQNNPVDLDDFSELF"
     CDS             complement(6079..7209)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.2;
                     E-value: 1.3e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_119"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.2e-18, bitscore:
                     57.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-19, bitscore:
                     63.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISSKFFIDSLCSMQMDFFTGVPDSLLKNVCAYITDHFVTERNVI
                     AANEGAAVGLAAGYYLATKKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLVGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIKYAIMSQNETEFLSQLNYANFYMNETHEPFAFV
                     IPKGTFEEYKLQQDGEVILPLKREAAIQLIASSLSKEDIIVSTTGMISRELFEYRTSAF
                     MEHEKDFLTVGSMGHASQIALGIALEKKKCKVFCFDGDGSTLMHMGSLAIIGSLHPDNY
                     VHVIFNNGAHDSVGGQPTVAFNIDLCKIAQACGYEAALSVSDSDSLCEALKRITYMHGP
                     ILLEVKVRKGARKDLGRPTTTPLQNKDTFMLFLNNQ"
     CDS             complement(7248..8525)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 206;
                     E-value: 1.2e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_120"
                     /sec_met_domain="CTP_transf_like (E-value: 6.8e-14,
                     bitscore: 45.3, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 5.3e-120, bitscore:
                     392.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.5e-64, bitscore:
                     210.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADIIHPGHLNIIHEAQKYGSVTVGVLTDAAIASYKRLPYLTYE
                     QRSLIVKNLKGVEEVIPQTTLDYVPNLELIKPDFVVHGDDWKDGIQKETRQRVIDTISK
                     WGGKVIDVPYTKGISSTQLNTQLKEIGTTPEIRLKRLKRLISAKKIVRICESHSGLTGL
                     IIENTSVEVNGIKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDALECTTKPVI
                     FDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQDTIEGFCDKI
                     KAGKRAQITADFMIIARIESFIAGKGLDDAMERALAYIEAGADGIMIHSKDKSGKDIRE
                     FCMTLRKKHKSIPIVVVPTTYNHITEDELASWGVNVVIYANHMLRSAYPAMLNTAKSIL
                     ANARSYEANDLCMPVKEILELIPGTK"
     CDS             complement(8515..9825)
                     /locus_tag="ctg2_121"
                     /transl_table=11
                     /translation="MDFLSKKFLYVFLFWWGAYLFCSTFNPCDLFLVSNETYIILLGYV
                     VSFLIGFSIFPIKYNHSIYKNRANILAIKTNWWYVLAGISSIIILYNYICKYLLLLEVV
                     GAXXXXYLLLLEVVGADEARESLFESGLLFSTNYEIYLFQFLFTPFQTIVQFFLAYCIV
                     FKSKFPPIYLMLFVLYFFLYGYLGGGRANYLALFLYVILLFVLRTQIASKLHCNIRKYS
                     FKFTFFLFFFCAIIFVIVSIQTTLRKGVTDIDGQTILMGFEELLSQFVWYMLGPIRALD
                     YAFEYQYDSFLGLWYGRATVGGFDTLLKMFIHALGGSYTTANQVIGGYLQEHLITVGYG
                     ITFNFAYTALIFYYLDFGYFGILLWPFFLGITTRFTVYKFQKKATFARLILMLFFFYTA
                     IFATFSWTFYKTASVVLIILLIIYQKYEQKSLCRHEC"
     CDS             complement(9882..10802)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_122"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1e-20, bitscore:
                     67.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLVSIICITYNQAEYLSSCLDSIFSQQVDFQVELIIHDDASTD
                     STTEIISQYIKKCPFQIKTILQKENQYSKGIDIFSKYIYPKVEGKYIAICEGDDYWTDS
                     RKLSIQIKMLEANQSFSATAHQSTVIYEKENREHLFCLLRKNIIKMDDVMGNRIFHTAS
                     FVFRSDIIPLLSIDIIPFAYDRFLFLVCSFYGDIYYFYDNMCVYRKSEIGITSHITYQI
                     HKRDLFVPKKLKEINSNFPYYRYMAYVNKAMLSSVDISLWNYICHSVTFLFYSFSYFPR
                     NIMDIYRWGYLTVWWMTKGRKFRMK"
     CDS             complement(10807..11349)
                     /locus_tag="ctg2_123"
                     /transl_table=11
                     /translation="MIGSTSFLTEEEIKSLGFKKYGDNLKISRFAHFYTPSTIEIGNNV
                     RIDDFCILSGNIKLGSNIHISAYCALYGAYGITMCDNTGLSPRATIFSSMDDFSGDFLI
                     GPIHDKSKINVQGGSVLLEEYVQIGSGSILFPKLKISKGCVVGAMSLVNKSLDEWGVYA
                     GIPVKKIKERRRGLLNL"
     CDS             complement(11357..12466)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     289.5; E-value: 6.7e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_124"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.3e-96,
                     bitscore: 316.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKVITVTSPLLPSLDDFIPYLQDIWNRKWLTNNGYYHQELEKA
                     LCEYLKVPYISLFTNGTLPLMCALQALRITGEVITTPYSFVATTHALWWNGIKPVFVDI
                     DPETCNIDPDKIEAAITPKTTAIMPVHVYGKPCDTERIQAIADKYGLKVIYDAAHAFGV
                     EVGGKSILNAGDMSTLSFHATKVYNTIEGGALICHDEKTKKRIDYLKNFGFAGETTVIA
                     PGINGKMDEVRSAYGLLNLKQVDAAIEARRQVAIMYRKGLEHVPGITFMEDMPGVRHNY
                     SYFPIFVDSEKYGMTRDELYFKMKERNILGRRYFYPLISEFSTYRGLESAKPENLLVAN
                     RVANSVICLPIYNSLSQIEIDRVISVISK"
ORIGIN
        1 tttctttcct gttgtattat tcaaattaaa gacttattca ctcttgattt ccgcgctctt
       61 cgccttttcc tccattccga ggtcttcgcg gatgaagcgg agtttcaaaa gaagcttttt
      121 catgccctcc acatccaggc gggcggtgtt atggctgtga tagtcctcta tacgggcaat
      181 atcctcattg ccttccgtga agaacttgtc atagttcagg tcacgggtgt cgcaggggat
      241 gcggtagtag tcgcccatgt cgacagcctt tgccatctct tcgcgggtta ccagtgtctc
      301 atacagtttc tcgccgtggc gcgtgccgat ggtcttcacc tccgtctcac cgtatttcgg
      361 atcaacctgc gcgtatgttt ccttcaaggc ctgcgccagt acatccaagg tggcggcagg
      421 agccttctgc acgaacaggt caccgttatg cccgtgttca aacgcataga ttaccaaatc
      481 cacggcatcg tccagcgtca tcatgaagcg ggtcatgttg gggtccgtta ccgtaatggg
      541 cctgccgttc tttatctgct ccacccacaa cggtattaca gaaccgcggc ttgccatcac
      601 attgccgtaa cgggtgcagc agatggtcgt tcctgcctct tcacccagcg cacggccctt
      661 ggctatggca accttctcca tcatggcctt gctgatgccc atggcattga tgggataggc
      721 agccttgtcg gtagaaagca ctactacatt ctttacacca tgcgctatgg cggattccag
      781 tacattgtcg gtaccgatca cattggtctg cacagcctgc aacgggaaaa actcgcaact
      841 gggaacctgc ttcaaggcgg cggcggaaaa cacataatcc actcccatca tggcaccgtc
      901 cacagactgg cggtcacgga cattaccaat gtagaatttt actttgggat tttgcaggtg
      961 atgacgcatg tcatcctgct ttttctcgtc acggctaaaa atacggattt ccttgatgtc
     1021 actatcaaga aaacgacgca atacagcgtt accaaaagat ccggtgcctc cggtgattaa
     1081 taaaactttg tccttgaata tagacataac tcactaatat ttttcctatt ttctaattct
     1141 tttatccaat cccaatagtt gataaagtct aataccaatc ttaaatgccc aggcattatt
     1201 cttatagtgc aagtattttt tcggcaattt atgatatgac attagttctt ccttactaat
     1261 agccagtttc tctgccactt catcaaacat ctttttacac tcctcatcag aagcaggagg
     1321 attctttaaa atttcaagag cttcttcacg gctcatttgt cccgtaataa tcaaacttga
     1381 taattgcgcc ctacgaatat catagccaaa ccgagtagga agccaccaag cctctagaaa
     1441 cttagtaagc aaatcctcaa aatgtttttg cccataaggt tgataatcat attcacgttg
     1501 aagggttgcc aacatttcag cttttgtaaa aggaacataa tttaggagtt gcaacgtctt
     1561 tactcctttt atgtatggaa gaacaaattt atgtttaaaa cctgtagtat aaatataatt
     1621 cttagtcttc acattgccgt gcttttttaa tacatccttt acataggttt tatctgccgt
     1681 aggtcctgca ccatcaaacc aagagtctgg gtcagcaaca atttcagtac aaatattata
     1741 accattcaaa atgtatttca cacccaattc ttccgaatat ttatctattt gagcaatgaa
     1801 agcatggtct tgaggaacat ccaacccggc atgtccggtc ttgaaaaatg caatctgcat
     1861 ctgcttcaac tcttcaaaat ccaacttctg aatatgaaga tggacattca gtttatcaca
     1921 gagcttttta atattctctt ctgctacagg cagattccat ccggcatcaa tatgaaacac
     1981 aaagggacga agcccccact ctttgactgc aagatgcagc atataacaac tatccaatcc
     2041 accactcagt cctaaaatac aatcgtattt tttacctttt cctgagattc ttacttgctc
     2101 caaaatggct ttcaactcaa cttcgtggcc tttgccatgg ttccaccaag gtaatatatg
     2161 ttgttcatac tctcggcatc tgtcacatac accattttca tcaaaagtca gattagaatc
     2221 agtcgtatcc attacacaat gggtacatac ttggtaattt ttatccatac tcttttctac
     2281 tttaacaaag tatcatacaa ttttatataa tcttcaaagc gttcattttt atcataatat
     2341 ttaacagctc gttttcgaca tatatgatga taaacttctt ttcctcgctt tactatttca
     2401 gctacagccc tctttatgcc ttttatatcc cctttttcta caatatatcc agtttcatct
     2461 gatacagact caacacttcc gccagtccga tatgtaatga caggtgttcc acaagctaaa
     2521 gattctagat ttgttgttgg aaatgtatct tcccaagttg ggttaataaa gacagaagct
     2581 aaagtgtaca aagtagctaa ttgagtaaca ttttcagttc tctcaattcc aattatgcca
     2641 tcggggattt ctttcaactg tgtttttgat aatcccacta aaacaataac ccaatcttca
     2701 gaaatcatgt tatacaattg aacgaaatcc tcaagcccct tgcgtttatc ccaaatacta
     2761 gctactccta ataaaacact agtttgctct gctaatccca atttatttct catggcacat
     2821 acactctgca aggattgagg agaaaaaagt tttagatcaa ttccattttg aattacattt
     2881 attggataat ttttcaagaa tgatttcttt acaatcattc ctagccactg tgataccggc
     2941 acaatagtca aattttccat agatgtaaac aacttttttt ttagttcata atttttaaaa
     3001 gacctatcta ttaatacact tccaggatat attttctttt gtacgcaagt ctcacaatgc
     3061 gtcaaccatt tctcacatcc gacatagtca aaatgagcac aatgcccagt cattgaccaa
     3121 cagtcatgaa aaacccatac cacaggtgta gaaatagaag ataaatactt aaataaaacc
     3181 tccatattca aaaaataccc atgaatgtga tgaagttgaa taatatcagg atgaatttcc
     3241 tcaatctgtt gtattaatct tctagtggct cgagtagagt gaagacaatg agtatcaaac
     3301 aaacgtgtca taattccatg ccaatacaca tcccattttg tacctatttt aatagtcata
     3361 gattgactag gcaaatgatt acgagcataa gttatataac tcttccaacc atgtgcaaga
     3421 gctacttgcc ctatttgttc agcaatacgt cctacagaac cagaattcac ctctatacta
     3481 atttgaagaa gagtaagcat aaagattaaa actattttag ggataaatca tctgttatat
     3541 aattataatt tctattagga atattccaat tcttgccata tcgtaaagtc aaatattcat
     3601 tcacatcaat tggaacttta aaatactcat cataaaagag aatatctttt gtattcgaca
     3661 acaaataggc aggaattaca atcttacgaa ttttaggttt agatttagct ataagtaaat
     3721 cctgcaaaaa agccccacct aaatagttca taaacgaaat tataaaataa ataaaattca
     3781 ctacttgacg agaaaaagaa tgagagtttc tataaagagc aagtcgtctt aaacagttat
     3841 aaattgaata taataaatca gatccttcta cttttgtcat tgttgaatta taaaaagtac
     3901 catttcgcaa atatgatttc aaatttattt cgcaattaca acgacgtaga tgaactgtat
     3961 ttgcagtaat aattacatca aaccctacta aatagagctc tcttcctatt gttttcgcta
     4021 aatgtttatc aaataagaaa tcaattattg cgatatcaat atcatcatcc caaggaataa
     4081 atgctctgtc tcggactgca cccaataatg tacctgtatc taaaatatat tttatagaga
     4141 atctatccaa tatatcccgt acaagtaata aggatgctaa ccattctttt tctttctgat
     4201 tcatttctgc aatactttat aattatgcgt tgaaatccgt ctttcaacag ggggcatttc
     4261 catataattt ccatagagtt gcataagcca tgaatttgtc ccaacaggtg cactataaga
     4321 ctcattttca aacacaacat tcattttact ttgaaaaata gaagcacaaa cgacctccct
     4381 attcttataa gctccctcca aaagatattc tgatgatttc tccatagaat atttcattgc
     4441 atagttgttt atagctttta aaactgtata taatggaaag ggaataaaaa taaatttcaa
     4501 gaatgcaaga atgatatttt taatcattcc tctttttctc acatatttca ttaatttaag
     4561 agttgcaata ttttgcaaaa accaaacaaa atgacaatgt attctttttc tcatttctga
     4621 acttggcaga ccatctatcg ggaaaacatc tatattaacc ccgatatcat aggaagagga
     4681 agaatcgtct actaatattg tatttttatc taaaactttt ccaaaatgat aaggataagt
     4741 agcatcctta cttattgaaa gaaattcgaa tctatcatgt ttaaataact tttcaaattt
     4801 taaataatca atacgaggca ttactatatc aatatcatca tcccaaggaa taaaaccttg
     4861 atgcctcaca gctcccaata aagttccata cgctaaataa taattcaacc catttttttc
     4921 acaaaatatt tttatttcac tcaatatttg tatctgaatt tgcttaaatt catcacaaga
     4981 caactccttc ataatatgtt tcaaaacaat tcactaaaat catctaagtc cactggatta
     5041 ttttgcaatc gctgcctatt tacactctct aaaatgaaat acttattaaa attttccggc
     5101 aacttcaatg gcaataaaat tcttttttct atatagtcac caatatcaat attacacaga
     5161 ttttttaaat attcaatctt ttgtttatac agagatgggg atatattttt tctaattcta
     5221 tgtatatcca tatttattga ccaaaaaaaa ggaaatgtca ttgctactgc atgcccatgt
     5281 ggatacccat aataagttgt aaatgaataa gagaaagcat gaggcgcagt cgttttagtg
     5341 atatttatag cacgaccagc ccaataagcc ccctccgaca ctttatttct catactatta
     5401 gtaggagaat ttacaactaa tggtaaatta ggccacaaaa gttcaattgc tctcttagca
     5461 aattcatctg actcttttgt agcataagca ttccagtaag cctctatagc ctgagccaaa
     5521 gcatcaaaac ctgcacaagc tgtcaaatac ctcggagtat tgtatgtgaa tgggggatat
     5581 acaattgcaa catcaggtaa aatagcatta tgttctacag aatatttcac tttattttta
     5641 tacaatactg caaaatgggt cgcctcactt cccgtaccgg ctgtagtggg aagaactatc
     5701 aatggaagca aatctttctc tttttcaaat ttaccacttg taggctcacc agaataagaa
     5761 taaaaaaagc gaagtagttt agccatatcc aatacactac ctccaccaac agcgacaatg
     5821 acagaacaag agtacttacg taatagtaat aaccctcttt ccaaatcttc gattttagga
     5881 ttttcttcaa aatcaaaata ctccgttact tcacaatcta attcactaaa aacagcagtc
     5941 ataatagatt tggcaccaca agtctcataa gagtttctgc cacgcaccaa aaaaaggtga
     6001 gaaaaagaaa actccttcaa aactaagagc aaattttcga ttgaagactc tcccaaaaaa
     6061 caacgctgct ccataaaatc attgattatt caagaaaagc ataaaggtat ctttattttg
     6121 taagggagta gtagtcggac gtcccaaatc cttacgtgct ccttttctta ccttaacctc
     6181 taacaaaata ggaccatgca tatacgtaat tcttttaagg gcttcacata agctatcact
     6241 gtctgaaaca gataaagctg cctcataacc gcaagcctga gctattttac acaaatcaat
     6301 attaaaggca actgtgggtt gtccacctac agaatcatga gccccattgt taaaaataac
     6361 atgtacatag ttgtctggat gtaaggaacc tattattgca agcgatccca tatgcattaa
     6421 agttgatcca tcaccatcga aacaaaaaac tttgcatttt tttttctcaa gagcaatgcc
     6481 taatgctatt tgagaagcat gccccataga acctactgtc aaaaaatcct tctcatgttc
     6541 cataaaagca gaagtacggt attcaaataa ctcacgtgat atcatacctg tagtagagac
     6601 aataatatcc tcttttgaca atgaagaagc tataagttga atagcagcct ctcttttcaa
     6661 aggtaatatc acctctccat cttgttgaag cttatactcc tcaaaagttc ctttgggaat
     6721 tacaaaagcg aaaggttcat gtgtctcatt catataaaaa ttggcataat tcaattgaga
     6781 taagaattct gtttcatttt gagacataat ggcatatttt atacccatag cttcaagtaa
     6841 aggaagtgtc actttgccct gcttaatatg ctggggctca tcttttactc ctggctcgcc
     6901 acgccatccc acaagtaaca ataaaggaat attgtaaact tctttatccg ttaatgacat
     6961 taaaggattg acagcattgc caagaccgga attttgcata taaacaactg gtattttttt
     7021 tgtggctaaa taatatcctg cagctaaacc aactgcagct ccctcattgg ccgcgataac
     7081 atttcgttct gtaacaaaat gatcggtgat atatgcacac acatttttca ataaagaatc
     7141 gggaactccc gtaaagaaat ccatttgcat ggagcaaaga gaatcaatga aaaattttga
     7201 agatatcata ataacaagaa tctcaaatta atagaatata aacgaagtta tttagtaccc
     7261 ggaatcaatt ctaatatttc tttgacaggc atacataaat cattagcttc atatgaacgg
     7321 gcattagcca aaatggactt tgctgtattt agcatggcgg gatatgcact tctaagcata
     7381 tgattggcat aaattactac attcactccc catgatgcta attcatcttc tgttatatga
     7441 ttatatgttg taggaacaac cacaataggt atggatttat gcttcttacg caaagtcata
     7501 cagaactccc taatatcctt acccgattta tccttactat gaatcataat gccatcagca
     7561 ccagcctcaa tatatgctaa tgcacgttcc attgcatcat ccagaccttt acctgcaata
     7621 aagctctcaa tacgagctat tatcataaaa tcagccgtta tctgagcacg cttaccagcc
     7681 tttatcttat cgcaaaaacc ttcaattgta tcctgggttt gaacagcgtc tgttccaaaa
     7741 agcgagttct tcttcagacc aattttatct tcaataataa ctgctgatat ccctaagcgc
     7801 tccaaagtac gaactgtaaa tacaaaatgc tctatttttc cacctgtatc tccatcaaaa
     7861 attacgggtt tagttgtaca ttccaaagcg tcattcagat catgaagacg ggtagtcaaa
     7921 tcaacagctt caatatccgg ttttccttta gaggtagaat cagtaagact actagaccac
     7981 attccatcaa actcacgttt aataccgtta acctcaacac tcgtattttc gataattaaa
     8041 cctgttaatc cactatgaga ctcacatatt cgaacaattt tcttggcaga aatcagacgt
     8101 tttagacgtt tcaagcgaat ttcaggggta gtaccaattt cctttaactg ggtatttaac
     8161 tgggtggaag atataccttt tgtataagga acatctatca ctttaccacc ccatttagaa
     8221 attgtatcta tgacacgttg acgagtttct ttttgaatac catccttcca atcatcacca
     8281 tgaactacaa aatcaggttt tatcaactct aaattaggaa cataatcaag agttgtttgg
     8341 ggaatcactt cttcaacgcc tttcaaattc ttcacaatta gcgaacgctg ttcataagtc
     8401 aaatatggca aacgtttata actagcaata gcagcatctg tcaatactcc aacagttaca
     8461 gaaccatatt tctgggcctc gtgaataata ttcaaatgcc ctggatgaat aatatcagca
     8521 ctcatgccga cataaacttt tttgttcata tttctggtat ataattagta atataattaa
     8581 cactactgaa gctgttttat aaaaagtcca tgaaaaagtc gcaaatattg cagtataaaa
     8641 aaagaataac attaatatca atcttgcgaa agttgctttt ttctgaaact tataaacagt
     8701 aaaccgagtt gttattccca aaaagaatgg ccacaacaat attccaaagt aaccaaaatc
     8761 taaataataa aatatcaatg ctgtataagc aaaattgaaa gttataccat aaccgacagt
     8821 tattagatgt tcttgaagat agccacctat aacttgatta gcggttgtat aacttcctcc
     8881 taacgcatga ataaacatct ttaaaagtgt atcaaatcca ccaacagttg ctcttccata
     8941 ccacaagcct aaaaaggaat catactgata ctcaaaagca taatctaacg ctctaatagg
     9001 tcccaacata taccatacaa attgggacaa caattcttca aatcccataa ggatggtttg
     9061 tccatctata tcagtgactc cttttctcaa tgtagtttga atagaaacaa tcacaaaaat
     9121 tattgcacaa aagaaaaaaa ggaaaaaagt aaatttgaaa gaatattttc gaatattgca
     9181 atgtaatttt gaagcaatct gggttcttag tacaaataac aatataacat ataaaaagag
     9241 agctagatag ttagcccttc ctcctcctaa atagccataa agaaaaaaat agagaacaaa
     9301 taacattaaa tatataggag gaaacttgct cttgaagact atacaataag ctaaaaagaa
     9361 ctgcactatt gtttgaaaag gagtaaacag aaactgaaat aaatatatct cataatttgt
     9421 actaaacaga agcccagatt caaaaagaga ctctcttgct tcatctgcac ctaccacctc
     9481 taacaacaac aaatacnnnn nnnnnnctgc acctaccacc tctaacaaca acaaatactt
     9541 acaaatataa ttatatagaa taatgatact tgatattcct gctaacacat accaccaatt
     9601 agtttttatg gctaaaatat tagctctatt tttataaatt gaatgattgt attttatagg
     9661 aaatatacta aaacctatta aaaaagaaac aacataccct aacaatataa tgtatgtttc
     9721 atttgaaaca agaaataagt cgcaaggatt aaatgtagaa caaaataaat atgcacccca
     9781 ccaaaacaaa aaaacatata agaatttttt tgataaaaaa tccattctac ttttttttaa
     9841 aagtaaaaat atgagagtaa aaaagcagaa tactatcaaa ctcatttcat acgaaatttt
     9901 cgacctttag tcatccacca aactgtcaaa tacccccacc tatatatatc cataatattt
     9961 ctaggaaagt atgagaaaga atagaacaaa aatgttacag aatggcatat gtaattccag
    10021 agagagatat ccactgaaga caacatagcc ttattaacgt aagccatata tctataatat
    10081 ggaaaattag aatttatttc tttcaacttt ttcgggacaa ataaatcccg tttgtgaatt
    10141 tgataagtta tatgactagt aatacctatt tcgctctttc gatatacaca catattatca
    10201 taaaaataat atatatcacc ataaaacgaa caaactagaa ataaaaaacg atcataagca
    10261 aaaggaatta tgtctattga aagcaaggga attatgtcac ttctaaaaac aaaagatgca
    10321 gtatgaaaaa tacgatttcc cataacatca tccattttta ttatattctt tcgtaataga
    10381 caaaacaaat gttccctatt ttctttttca tatataacag tagattgatg agctgttgcc
    10441 gaaaaagatt gatttgcttc taacatttta atttgaatag atagtttccg agaatccgtc
    10501 caataatcat ctccttcaca aatagcaata tatttacctt cgaccttagg atatatatat
    10561 tttgaaaaaa tatcaattcc tttagaatat tgattctctt tttgtagaat agttttaatc
    10621 tgaaaagggc atttcttgat atactgagaa attatttcag ttgtactatc tgtagaagca
    10681 tcatcatgta ttatcaattc tacttgaaaa tccacctgct gagaaaaaat actatctaag
    10741 catgaagata aatattcagc ttgattataa gtaatgcaaa taatacttac caatggcttc
    10801 ataaaactat aaattcaata atcctctacg gcgttcttta atttttttta caggtattcc
    10861 tgcatatacc ccccattcat caaggctttt attaaccaaa gacatagctc caactacaca
    10921 ccccttagat attttcaact ttggaaacaa tatacttcct gaaccaattt gcacatattc
    10981 ttctaacaaa acggaaccac cctgaacatt tattttgctt ttatcatgta ttggacctat
    11041 taaaaaatca ccactaaaat catccattga gctaaaaatt gttgcacgag gagaaagtcc
    11101 tgtattatca cacatcgtta ttccataggc tccataaagt gcacaataag cagaaatatg
    11161 aatatttgat ccaagtttaa tattcccaga taatatacaa aagtcgtcaa tacggacatt
    11221 attacctatt tcaatagtag aaggggtata aaaatgagca aaacgactaa ttttcaaatt
    11281 atctccatat tttttaaacc ctaacgattt tatttcttct tccgttaaaa aagacgtact
    11341 accaatcata aaaagattat ttcgatataa ccgatattac tctatcgatt tctatttgtg
    11401 ataaagaatt atatataggc aaacatatta cactatttgc cacccgattt gctactaata
    11461 gattctcagg cttagccgat tccaatcctc gataagtaga aaattcgctt atcaacggat
    11521 agaaatacct acgccccaat atattccgtt ccttcatctt gaaataaagt tcatcgcgtg
    11581 tcatgccata tttctcagaa tccacgaata tgggaaagta agagtaatta tgacggactc
    11641 cgggcatatc ttccataaaa gtgataccag gtacatgttc caagccttta cgatacatga
    11701 tagccacttg acgacgagct tcaatagctg catccacttg tttcaaattc aacaaaccat
    11761 aagcactacg tacttcgtcc atcttgccat tgatacccgg agctatgaca gtcgtttccc
    11821 ccgcaaaacc gaaattcttc aaatagtcga tacgcttttt agtcttctca tcatgacaaa
    11881 tcaaagcacc accttcaatc gtattgtaaa ctttggtcgc atgaaaactc aaggttgaca
    11941 tatctccggc attcagaatt gattttccac ccacttctac cccaaaagca tgggcagcat
    12001 cataaatgac cttcaaaccg tatttgtccg ctatcgcctg gatacgctct gtatcacaag
    12061 gcttgccata aacatgtacc ggcataatcg ccgttgtctt gggggttatt gccgcttcta
    12121 ttttgtccgg atcaatgtta caagtttcag ggtcaatatc cacaaatacc ggtttgattc
    12181 cattccacca caaagcatgg gtggtagcta caaagctata cggagttgtt atcacctcac
    12241 cagtaatacg caatgcttgc agagcacaca tcaaaggcag tgtgccattg gtaaaaagac
    12301 tgatataagg caccttcaaa tattcacaca aggctttctc caattcttga tgataataac
    12361 cgttattggt cagccactta cggttccaaa tatcctgtaa ataaggaatg aaatcgtcaa
    12421 gcgaaggaag taatggagaa gtaactgtaa tcactttatt ttccatctta ctataaaaat
    12481 atatactgat ttctattttt tgtgaagagc cgacaaccca agccgtttta cctcaagata
    12541 ctctggtaat cttaatcttt cataaacagc aaaagctaat gtcaaaccaa caataatctg
    12601 aatgggtaat tgaatataaa cggatatatc caataaggaa aaaagccaca tgatagtaga
    12661 aactatcaaa gaaactacaa aaaccggaag cacatcctta atttgttcta tggtagaata
    12721 gcatatcaaa tcggcagaat aatggctatt taagaaatag gctatgaaag aggttaagac
    12781 actcccccac agcatatatt cgatgccata aaaaatacct atcagaatag gaaacaccgc
    12841 aatggtcttc tttatgattt ccagtttcag aaacaagtcc gaacgtcctt tcacctgcaa
    12901 gatattcaga ttgatggcat gaagcggata aagcatacca ctgaaacaaa tgatctgcag
    12961 aaaggaaacg gcagtcaacc atttctcacc gatcagaatt ataatcaaag gtttagccac
    13021 agctgcaagt cccagcatgc aagcgaatgt cacaagcatt gtagtcttta ttatctgccg
    13081 ataagcttca cgcaagcgct ccggttcttc ttgaatggaa ctaagcaccg gataactgac
    13141 acgctggaca atactggtca gattactgga aaatatcgta ttgaactgct ctgcacgagt
    13201 atattgcccc aactgtgcag aactgtaaca acggcctata accacataat aaacattctt
    13261 gtaaagagta tccaataatc cggacaacaa gagcttatag ccaaagccga acatttcctt
    13321 gaagcttttt acggagaatt cccattgggg catccattta cagaatatcc aaagaaacag
    13381 agaattcaga atctgccggg aaagctgttg ccacaccaaa ctccatacac caaagcccac
    13441 tatagccatg cctacgccaa ccaatccact tgaaacagaa gagattatgg acactttggt
    13501 ctgtgtctta aaatcaatac ctctt
//
