LOCUS       c00090_gnlPro..        14757 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IPMLADIA_106.
ACCESSION   c00090_gnlPro..
VERSION     c00090_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 19:25:28
            Original ID  :: gnl|Prokka|IPMLADIA_106
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14757
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14757
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7990:13891]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7991..13891
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(109..1170)
                     /locus_tag="ctg90_1"
                     /transl_table=11
                     /translation="MKLNIAVLPGDGIGPEISVQGVEVMSAVCEKFGHEVHYEYALCGA
                     DAIDKVDDPFPEETYRICKDADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFA
                     NIRPVQTFKCLLHKSPLRAELVDGADFLCIRELTGGMYFGEKYQDNDKAYDTNMYTRPE
                     IERILKVGFEYAMKRNKHLTVVDKANVLASSRLWRQIAQEMAPSYPEVTTDYMYVDNAA
                     MRMIQEPKFFDVMVTENTFGDILTDEGSCISGSMGLLPSASTGESTPVFEPIHGSWPQA
                     KGLNIANPLAQILSVAMLFEYFDLKEEGALIREAVDASLDANVRTPEIQVEGGAKYGTK
                     EVGSWIVNYITEK"
     CDS             complement(1186..1629)
                     /locus_tag="ctg90_2"
                     /transl_table=11
                     /translation="MKKLTIALVAHDNRKAEMVEWAVHNAEFLSHHHIVCTGTTGNLVR
                     KALEEKGVNADIACMHSGPMGGDAEIAAMVVRKEIDLAVFLIDDLNPQPHEADIQMLLR
                     QCRVHNVPIACNRYSADLMITSTLWDDDTYFPTEPKYVHFNRE"
     CDS             complement(1650..3164)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_3"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEIMDTTLRDGEQTSGVSFAAHEKLSIAQVLLSDLGVNRVEIAS
                     ARVSDGEFEAVKRVAAWAARSGNLDKLEVLGFVDGTVSLDWIESAGCRVVNLLCKGSYK
                     HVTEQLRKTPEQHVDDIRTVVLEAAKRKIDVNIYLEDWSNGIKHSPDYVFLVIDALKGL
                     PIRRFMLPDTLGVLNPGNTYEYCKMMVDRYPDLRFDFHAHNDYDLAVANVYSAIRAGIK
                     GIHTTVNGLGERAGNAPLSSVLAVIKDQLGEETSLREEKINKASRLVETYSGVHIPPNK
                     PIIGEHVFTQCAGVHADGDSKNNLYCNDLLPERFGRVREYALGKTSGKANIRKNLEALG
                     IDMDEGSMRKVTERIIELGDKKEMVTPEDLPYIISDVLHHDNALEDQKIRILNYSLSLA
                     QGLKPVATLKIEINGEAYEESASGDGQYDAFVRALRRIYSRLNRPFPMLTNYSVSIPPG
                     GRTDAFVQTVISWNYAGVDFKTRGLDADQTEAAIKATLKMLNKIED"
     CDS             complement(3167..3754)
                     /locus_tag="ctg90_4"
                     /transl_table=11
                     /translation="MKTKFNIITSTCVPLPLENVDTDQIIPARFLKATTKEGFGENLFR
                     DWRYDKEGNKIESFVLNDPTYSGKILVAGKNFGSGSSREHAAWAIADYGFRVVVSSFFA
                     DIHKNNELNNFVLPVVVTEEFLAELFDSIYKDPKTEVEVNLPEQTITNKATGKSEHFEI
                     NAYKKDCLINGLDDIDYLLANKSKIEAFEAAR"
     CDS             complement(3781..5178)
                     /locus_tag="ctg90_5"
                     /transl_table=11
                     /translation="MSKTLFEKIWDKHVVDTLPDGTIQLYIDRLYCHEVTSPQAFAGLR
                     ARGLKPFRPAQITCMPDHNIPTLNQDKPIEDPISKNQVDTLEENAKYFGLTYYGLQHPK
                     NGIIHVVGPETGLTQPGMTIVCGDSHTSTHGAMGAIAFGIGTSEVEMTLATQCIMQRKP
                     KTMRITIDGVRKPGVTAKDFALYIISKMSTSGATGYFVEYAGEAIRNTTMEERLTICNL
                     SIEMGARGGMIAPDDVTFDYLKDREFAPRGEEWERKVSEWRQLYSDPDAKFDKEIVFHA
                     EDIDPMVTYGTNPGMGMSISKDIPSLESVPEAGRISYKKSLDYMGFKAGESMLGKKVDY
                     VFLGSCTNGRIEDFRAFASLVKGKKKADDVTVWLVPGSWQVEREIRAEGIDKVLAEAGF
                     VLRQPGCSACLAMNEDKVPAGKYAVSTSNRNFEGRQGPGARTILAGPLVAAAAAVTGKI
                     TDPRELM"
     CDS             complement(5193..6695)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_6"
                     /sec_met_domain="HMGL-like (E-value: 5.5e-95, bitscore:
                     307.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEA
                     GFPVSSPGDFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALKFAKRGRIHTGIGTSD
                     SHIKYKFNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGA
                     TVVNIPDTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGA
                     RQVEVTVNGIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQ
                     PNKAIVGRNAFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRL
                     HVLGVDLEQEKLDKVYDEFLKLADRKKDINDDDVLMLVGKDRTATHRIKLEYLQVTSGV
                     GVQSVASICLNLSGVRKYEAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDD
                     TGKVHMQVEYNGATYYGFSANTDIIAASVEAFVDAINKFIVD"
     CDS             7377..7610
                     /locus_tag="ctg90_7"
                     /transl_table=11
                     /translation="MTKLSNIPAKETTAKTAKTRKAKTEPAKPKWDPTKPMQFTQEEIR
                     EHIHEIEKGPFYPIEEVHQRIRSWMDSYQGKK"
     CDS             7580..7921
                     /locus_tag="ctg90_8"
                     /transl_table=11
                     /translation="MDGQLSRKKVIGSPIYEESLERTFVEGIERFGMFQARKYLEHILN
                     TVEKLENDYPYYPECRHLTTKSRMYRNIILDSHLIIYRITEERIEVLDIFHSASSMRKI
                     KKTKNIHIE"
     CDS             complement(7991..9034)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_9"
                     /sec_met_domain="IlvN (E-value: 1.8e-47, bitscore: 150.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.9e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(9084..9809)
                     /locus_tag="ctg90_10"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKNREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(9816..10370)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_11"
                     /sec_met_domain="ALS_ss_C (E-value: 1.7e-17, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             complement(10499..12088)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.6e-40, bitscore:
                     127.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMKNPDFVRSLKPMVSPVVPLK
                     SGRNWTTLSLRC"
     CDS             complement(12122..13891)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_13"
                     /sec_met_domain="ILVD_EDD (E-value: 1.8e-215, bitscore:
                     706.2, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MACQRDERGTVRQAIIAIVNSFTQFVPGHTHLHEVGQLVKAEIEK
                     QGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKI
                     TPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLIDAMIESADTSVSDERIEQVERHA
                     CPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENAYKYY
                     RDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDMLSR
                     KTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYA
                     VTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAYSKDGGLA
                     VLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVISGDVVVITYEG
                     PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLV
                     RDGDIIEINIPERSINVRLSDEELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMV
                     SSADKGGVRIVED"
     CDS             complement(14492..14701)
                     /locus_tag="ctg90_14"
                     /transl_table=11
                     /translation="MSLLELLLAWGMPDLVLILGDFIRMLTKFSPILDEISSLCSSENF
                     LMFFLEHYYEFFKAIYSLQVLINM"
ORIGIN
        1 atcggctcac gcgagtagtg gcgtaggcca atgccactac tcgcgtgagc cgatgccact
       61 atacgtgcga gcctgcgcca ctactggtgc gaaatcggcc tatttatact acttttccgt
      121 gatataattg acaatccaac tacccacttc tttcgttcca tatttcgctc caccttccac
      181 ttggatttcc ggcgtacgga cattcgcgtc gagggaagcg tctacggctt cacggatcaa
      241 ggctccctct tctttgaggt cgaaatactc gaataacatc gctactgaaa gaatttgcgc
      301 caaggggttc gcgatattca gccctttcgc ctgcggccaa gagccatgga tcggctcgaa
      361 aaccggtgtg ctctctccgg tagaagcgga aggcagcaag cccatagagc cgctgatgca
      421 agaaccctcg tccgtcaaga tatcaccaaa cgtattctcg gttaccatca cgtcgaagaa
      481 tttcggctct tggatcatac gcatagcggc attgtccaca tacatatagt ctgtcgttac
      541 ttccggatag ctaggagcca tctcttgagc gatctggcgc catagacggg aagaggcaag
      601 tacgttcgcc ttgtcaacaa ccgtcaggtg cttattccgt ttcatcgcat actcgaagcc
      661 cactttcaag atacgctcaa tttccgggcg ggtatacata ttcgtatcgt atgccttatc
      721 gttgtcttga tatttctcac cgaaatacat acccccggtc aactcacgga tacataagaa
      781 atccgcgcca tccaccaatt cggcacgcaa cggcgattta tgcaataggc atttgaaggt
      841 ctgcaccgga cggatattag cgaacaggcc caacttctta cgcatcgcca aaagaccttg
      901 ctccgggcgt actttcgctg tcgggtcatt atcaaactta ggatcgccca cggccgagaa
      961 aagaacagcg tcggcatcct tacaaatccg ataggtctcc tccgggaaag gatcatctac
     1021 cttatcgatc gcgtcagcgc cacaaagggc atactcatag tgaacctcat gtccaaattt
     1081 ctcacaaacg gcactcatta cttccacgcc ttgcacggaa atctctggtc cgatcccgtc
     1141 tccgggaagt actgctatat tcagtttcat cgtaaatgtt tgttattatt ctctgttaaa
     1201 atgtacatac ttaggctccg tggggaaata cgtgtcatca tcccacaggg tacttgtaat
     1261 catcaagtcg gcgctataac ggttacaagc gataggtacg ttatgaacac ggcactggcg
     1321 aagcaacatc tggatgtcgg cctcgtgcgg ttgcggattc aagtcgtcta tcaaaaagac
     1381 cgccaaatcg atctccttac ggacaaccat agcggcaatc tcagcatcgc ctcccatcgg
     1441 accggaatgc atgcaagcaa tatccgcgtt cacccctttt tcctcgagag ctttacgaac
     1501 caaatttccg gtcgtacccg tacaaacaat atggtggtga gacaagaact cagcgttatg
     1561 taccgcccat tctaccattt ccgccttacg attgtcgtgc gctacaagcg cgatagtcaa
     1621 ctttttcata ccctttacct ttttaattat taatcctcta tcttgttcag catcttcaat
     1681 gtcgccttga tcgccgcctc ggtctggtca gcgtccaggc cacgagtctt gaaatcgacc
     1741 ccggcataat tccagctgat gaccgtctgc acaaacgcat ccgtacgtcc tcccggcggg
     1801 atggataccg aatagttcgt caacatcggg aacgggcggt tcaaacggga ataaatccgg
     1861 cgtagggcac gaacaaaagc gtcgtattgg ccatcaccgg aagccgattc ctcgtaagcc
     1921 tcgccattga tctcgatctt caaggtagcc accggtttca gcccttgggc caaggataag
     1981 gaatagttca agatccggat tttctgatcc tccagcgcat tatcatgatg aagcacatcg
     2041 ctgataatat aaggaagatc ctccggggta accatttctt tcttatcccc taactcaatg
     2101 atccgttccg taaccttacg catcgaaccc tcgtccatgt cgataccgag cgcttccaga
     2161 ttcttgcgga tattcgcttt tccggaggtc ttgcccaagg cgtactcgcg aacccgtccg
     2221 aaacgttcag gaagcaagtc gttgcaatac aagttattct tgctatcacc gtctgcgtga
     2281 acaccggcgc actgcgtaaa cacatgctct ccgatgatcg gcttattggg cgggatatgc
     2341 accccggagt aggtctcaac caaacggcta gccttgttta tcttttcctc cctcaagctc
     2401 gtctcctctc ccaactggtc cttgataacg gcaagtacgc tactcaaagg agcgttaccc
     2461 gcacgctctc ccaaaccgtt cacggtcgta tggattccct tgatacccgc acggatggcg
     2521 gaatatacat tcgcgacggc aagatcatag tcgttatgcg catggaagtc aaaccgtaaa
     2581 tcagggtaac ggtccaccat catcttgcaa tactcgtagg tatttccggg attcaagact
     2641 cccaaggtat ccgggagcat gaaacggcgg atcggaagtc ctttcaacgc atcgattacc
     2701 aagaatacgt aatccgggga atgcttaata ccgttcgacc agtcctccaa atagatattc
     2761 acgtcgatct tccgtttcgc cgcttccaat acgaccgtac gaatatcgtc aacgtgttgc
     2821 tcgggagtct ttcgaagctg ttcggtgaca tgcttataag agcccttgca aagcaagttc
     2881 acgacacggc aacctgcgga ttcaatccag tcgagagaga ccgtaccatc cacgaaaccc
     2941 aagacctcca atttgtctag gtttccggaa cgggcggccc aagcggctac acgcttcacg
     3001 gcctcaaact ctccgtccga cacacgggcg gaggcgatct ccacccggtt cacgcctaag
     3061 tcgctcagca gcacttgcgc tatgctgagc ttctcgtgag cggcgaagga gacgcccgaa
     3121 gtttgctccc catctctgag ggttgtatcc attatttcta tcataatcag cgtgctgcct
     3181 cgaaggcttc tatctttgat ttatttgcca gtaaatagtc gatatcgtcc aatccgttga
     3241 tcaggcaatc ctttttatag gcgttgatct cgaaatgctc gcttttgccc gtagccttgt
     3301 tcgtgatcgt ttgctccggt agatttacct cgacctcagt tttcgggtcc ttgtaaatcg
     3361 aatcgaacaa ttcagcgagg aactcttcag tcacaacaac cggcagcacg aagttgttca
     3421 actcgttgtt tttatggata tcggcgaaga aactggagac cacgacacgg aaaccgtaat
     3481 cggcgatcgc ccaagccgca tgctcacggc tggaaccgga accgaagttc tttcctgcta
     3541 ccaatatctt tccgctatac gtaggatcgt tcaagacgaa tgattcgatc ttattacctt
     3601 ccttatcata tcgccaatcc cggaataagt tctcgccgaa cccttccttg gtagtcgctt
     3661 tcagaaagcg ggctgggata atctggtcgg tatccacgtt ctctaaagga agaggcacgc
     3721 aagtgcttgt gattatattg aattttgttt tcatcttatg ctactttatt agattagtct
     3781 ttacatcagt tctctcgggt ccgtgatctt acctgtcaca gcggcggcgg cggccacaag
     3841 cggccccgcc aagatggtgc gagcacccgg tccttggcgg ccctcgaaat tacggttgga
     3901 agtggagacc gcatatttac ccgccggaac cttatcctca ttcatcgcca gacaagcgga
     3961 acatcccggt tgacgaagga cgaagccggc ctcggccaaa accttgtcga tcccctcggc
     4021 acgaatctcc cgttctacct gccaactgcc gggaaccagc caaaccgtta catcatccgc
     4081 tttcttcttt cctttcacca aagaggcgaa agcacggaaa tcctcgatac ggccattcgt
     4141 acagctacct aaaaagacat aatccacttt cttacccaac atagactcgc ctgccttgaa
     4201 gcccatataa tccaaagact tcttataaga gatacggcct gcctcgggca cgctttctaa
     4261 ggaggggata tctttgctga tactcatacc catgcccggg ttcgttccgt acgtaaccat
     4321 cgggtcgata tcctcggcgt ggaaaacgat ctccttatcg aacttagcgt ccggatcact
     4381 atacagctga cgccactcgc tcaccttccg ctcccattcc tcgcctctcg gggcaaactc
     4441 acggtctttc aaataatcga aagtaacatc atccggagcg atcataccgc cacgggcacc
     4501 catctcgatc gaaaggttac agatcgtcag acgttcctcc atggtcgtat tacgaatcgc
     4561 ctcgccagcg tactctacga aatagcccgt agcaccgctg gtactcatct tactaataat
     4621 gtataaggca aagtccttcg ccgtaacgcc cggtttacgt acaccatcga tcgtgatacg
     4681 catcgttttc ggcttacgct gcatgataca ttgggtagcc aaggtcatct ccacctcgct
     4741 cgtaccgata ccgaaggcga tagcgcccat ggcaccgtgc gtagaagtat gggagtcgcc
     4801 acaaacgatc gtcatacccg gctgcgtcaa gcctgtctcc ggacctacca catggatgat
     4861 accattcttc ggatgttgaa gaccgtaata cgtcaagcca aaatacttag cgttctcttc
     4921 caaggtatcc acttgattct tggatatagg gtcctcgata ggcttatctt ggttcaatgt
     4981 cgggatattg tggtccggca tacaagtgat ttgcgcggga cggaagggct tcaatccacg
     5041 tgcacgtaat ccggcgaaag cctgcgggct agtcacctca tgacaataca gacggtcgat
     5101 atacaattgt atggttccgt cgggcaacgt gtccaccacg tgtttgtccc agattttctc
     5161 aaataatgtc ttgctcattg tcttgtctat ttttagtcta ctataaactt attgatggcg
     5221 tccacgaaag cctccacgga agcggcgata atatcggtat tcgcggagaa cccataatag
     5281 gtagccccgt tatactctac ctgcatatgc accttgcccg tatcatcgct acctttatta
     5341 atggcttgaa tcaagaattc ctgaatcgtc atgtcactat tactaatggc ttttttcacc
     5401 gccttgatac ccgcatcaac cggaccgtta ccagccgcgg cctcgtattt tcttactccc
     5461 gacaaattta aacaaatact tgcgactgat tgtactccaa caccactagt tacctgtaaa
     5521 tattccaatt taatacggtg tgtggccgta cgatcctttc cgaccaacat caaaacatca
     5581 tcatcattaa tatctttctt acgatcggcc agtttcaaga actcatcata caccttgtcc
     5641 aatttctcct gctccagatc cacacctaaa acatgcaggc gatgcttcaa cgccgcacga
     5701 ccgctacgag cagtcaatac gatcgcgtta tcatcgatac ccacatcctt cggatcgatg
     5761 atctcgtagg tttgcgcatt cttcaaaacg ccatcttgat ggataccaga ggagtgagcg
     5821 aacgcgttac gtccgacaat agccttattc ggttgtaccg gcatattcat caagctagaa
     5881 accatacggc tcgtactata gatcttattc gtcgtgatat tggtaataat atcacgttct
     5941 ttatggctct tgaaaaccat ggcgacttct tccaatgacg tgttacccgc acgctcaccg
     6001 ataccgttta cggttacctc cacctgacgg gctccgttca acacgccttg tacggtattc
     6061 gcggtagcca tacccaagtc attatggcaa tgagtggaaa gaatagcgtt atgtacgcca
     6121 tccacatgtt ccatcagata cttaatcttc gccccgtact catccggcaa gcaatatcct
     6181 gtcgtatccg ggatattcac tacggtagcc ccggccttga tcacggcctc cacgacacgg
     6241 gccagatatt cattatccgt acgcccggca tcctcacagt agaattctac gtcctccaca
     6301 tactttttag cgtatttcgt ggcggcgatc gcacgctcta taatctcctc tctcgtggag
     6361 ttaaacttgt atttgatatg agaatcagaa gtaccgatac ccgtatgaat acgtcctcgc
     6421 ttagcgaatt tcaacgcctc ggctgccacg tcgatatctt tctccaccgc acgggtcaag
     6481 gcacagatgg tcggccaagt cacggccttt gagatctcaa ccacactctt aaaatccccg
     6541 ggactggaga cagggaaacc agcctcgatc acatcaacac ctagctgttc caacgcctta
     6601 gctacttgaa tcttttccac tgtattcaac tggcatcccg gaacctgttc accatcacgt
     6661 aaggtggtgt cgaaaataaa taatctgtct gacataatct tatattctta atttactaat
     6721 atcctatact aactaaaaaa gcctctctca caaggaagtg agaaaggctc tttcatctat
     6781 cgtaatgctc gcaaagcata cagtctcact tcctatcccg ttcccagagt agaataatgt
     6841 ttagagaaat aatgagacta ttttgcaagt tgcgtgtcat tgttcttgtc tttattgttt
     6901 ttgtttcaac gttgcaaaga tacagccttt ttcgagacca gcaaatataa ttcgaagttt
     6961 tttacaggat atttcttata aaacgtaaga taaacaatta catctgttac taaataacac
     7021 tgcccatcgt tgggtcgtaa cgatggcagt ataagctgct tacgttgccc atcataaagg
     7081 ccttatgatg ggcagtgtta tgaaatatgt gagacagctc attttaacga gctacgatct
     7141 tcttcacgaa caagagcagc gtattaccgg ataacatcaa ggaacgcaat actgttttat
     7201 tcttaggcaa ggtaagcttc tctaccctat tgaggagatg agacggggca cgccccgtct
     7261 ctacaactgg gtaatgagtt aatcttataa acctactttt ttccttacca aatatcttat
     7321 tacatggaaa ttattccata catttgccac tgtactaata aataactgtt acgactatga
     7381 caaaattaag caacatcccc gccaaggaaa ctacggccaa gaccgcaaag acacgtaagg
     7441 ccaagaccga gcccgcaaag cccaagtggg atcctaccaa gccgatgcaa ttcacccaag
     7501 aagagatccg ggaacatatc catgagattg agaagggacc gttctatcct attgaagaag
     7561 tacatcaaag aataagatca tggatggaca gctatcaagg aaaaaagtaa tcggttctcc
     7621 catttacgag gaaagccttg agaggacttt cgtggaaggc atagaacgat tcggtatgtt
     7681 ccaagcccgg aaatatcttg agcatatatt gaatacagtc gagaaactag aaaacgacta
     7741 tccttattac cccgaatgcc gacacctaac cacgaaaagc cgcatgtacc ggaacatcat
     7801 cctagattca caccttatca tctaccgcat caccgaggaa cggatcgagg tgctggacat
     7861 cttccattcc gcatccagca tgcgaaagat caagaaaaca aagaatatcc acatcgaata
     7921 acacaaagaa aggcgagcca cccgtaagtg acccgcctct ttttgctgat atataaggat
     7981 taagattgga ttagttgttc tccggacgaa gcttgcgtac agtaacagct gtctgccaca
     8041 tctcgctctc gcgcaatgcc ttcaattcag cctccaattt ctcacgataa tccggcttag
     8101 agtttgagtc gatagagatc tgagcctcgt taccgcattt tacgttcgcg tacaatttct
     8161 cgacaaccgg cttgattgcg tcgtggaacg gacccatcca gtccaaagcg ccacgctggg
     8221 cggtagtaga gcagttcgcg tacatccagt ccataccatt cttggcgaat aaaggcatca
     8281 aggattgagt caactcctcg accgtctcgt tgaaagcctc agaaggagtg tgtccattct
     8341 cgcgcaatac ctcatactgg gccaacaaca aaccttggat agcgcccatc aaagaaccac
     8401 gctcaccagt caaatcggaa gtagcctcac ggatgaaagt cgtctcgaac aagtagccgg
     8461 aaccgatacc gatacccaac gccaacgtac gatccatcgc cttgccagta gcgtcttgat
     8521 agatagcgaa agaagagttc aagccacgac cctcaaggaa catggaacgc aaagacgtac
     8581 cagacccctt cggagcgacc atgatcacgt caatatccgc gggaggaaca acgcccgtac
     8641 gatcgttcca agtgatcgcg aaaccatgag agaaatacag ggccttgcca gctgtcaaat
     8701 aaggcttcat cgtaggccat acagacatta cggcagcgtc ggacaacaag cacatgatga
     8761 tcgtggcctt gtcgcaagcc tcctcgatac cgaacagagt ctcacccgga acccatccgt
     8821 cctcaaccgc tttctcgtaa gtcttacctt ggcgctggcc aacgattacg ttgaaaccat
     8881 tgtcacgaag gttcaatgac tgtcccggtc cctgtacgcc atagccgata acagcgattg
     8941 tctcatcttt taatatctct cttgcctttt ccaacggaaa ttcctcgcgg gtcattacat
     9001 tctctacaac accgccaaaa ttcatttgtg ccattttctt tttaactatt aatgtttaaa
     9061 aaactattta tgtatctctt ttattatctc caagtaaccg ccgcacgaca gatcgccttt
     9121 ccctcatggc aaatagccat gtcttgctta tcgggagcgg actccgcctt atgaagcgta
     9181 agcggcatac cttgtttacc ctcggattgg taggcgatct ccagacggcc gatctcacgg
     9241 ttcttgaact ggtcgatatc gaacaaatcc agcagatgct cgatatactt cacgctattg
     9301 aagtgaccgt tgatatccaa gtcgctgtat ttgatcgaat acgggattcc ctccgcctta
     9361 ttctccgccg gcatgatctt gcccggcttc tcgatcgggc acggacgctc gtcgatatat
     9421 ttgcccaatg cctctatatc caataaggta ggacggcggg tctccacatc gatagccgcc
     9481 cagatagaac gggcgaatcc aaaggttttc ccattctcat ccgccagctc aaaacaacga
     9541 ctggtgaaga ggcgtccgac ctcatcgatc caagtgtata gattaatctt atcgaaggcg
     9601 gtaggatatt ccttcatctc gatagccaga cgggacaaca cccaagccgt atgacgctcc
     9661 gacatatcat tgaaaccgaa cccacgctct ccggcatggc tggaagcggc gtgaatcaaa
     9721 tagttaccaa tcatagggag cgttacacgt cccctaaaat ccatcaaata cggctccgcc
     9781 acgaaatgaa ataatcctac tttctccata tcttattatt gttgcttttc atgtaacttt
     9841 cgctccatat cggccaacat atcgctcaag cgctccacct tgctcttcgt gatagccaca
     9901 cgtccggagc ggatgaattg caggacaccg atcgtctcgc tcaactcatt gaacaaggct
     9961 tgtgtctcgt catagtggcc actcttctcc aacaccacgc aggtctcgtt catctccaag
    10021 atacgagcgt tgtatttacg gatcaatccc tccacggttc ccatcttgat gaaaagctcg
    10081 gtacttagct tataaagagc gatctcttga taaaccaaat cctcatccgt attataataa
    10141 gccttcaaga tatccacacg tttatcgatc tgtttcacca ccttatcgat catatcctca
    10201 tcggcgaatg tcgtgatcgt aaacttatgg atgcccttga tagcggacgg agagacggac
    10261 agagtctcga tgttcagctg tcggcgtgta aagataatcg ttatctggtt caaaagacct
    10321 acgatattct ctgaaaagat aataacggta tataatttct ttgttgtcat agcttcatct
    10381 cctccttatt tctcgtctcc cataatcatg tttgtcacgc ttcccccggc aggaaccatc
    10441 ggatatacca ttccgcaagt ctccacgtta gcgaccaaca cgtaagcgcc gtcgtggttt
    10501 agcatctcag cgatagcgtc gtccaattcc tcccgctttt caacggcacg accggcgata
    10561 ccataggctt tagcgatcgc acgaaatccg gattcttcat gatggtgttt gaataacgct
    10621 cgtggaagaa caattcttgc cactgacgta ccatccctaa gaagttatta ttaagaatga
    10681 taatcttcac gttcagtttc tcctgcatga tagtgcccaa ttcctgaatc gtcatctgca
    10741 tacccccatc accggtaaag aagcagaccg tacggtccgg agccccgaac ttagcgccca
    10801 tagcggccgg cagaccaaat cccatcgtac ctaaaccacc ggaagtcacc acgctacggg
    10861 tttgtttata tttgaaatag cggacgccca tcatctggtt ctgcccaacg tcggtcacca
    10921 atacagcgtc gttaccggtc gcctcggaaa ccttacggac tacctcgccc attttcagtt
    10981 ggccctcggt cggatacaat tccttctcga ttaccttatc gtattcctct ttctcgtccc
    11041 gatcgaactc ggcattccat tccggacgtt tacgttcttc caacaacgcc gtgatcatcg
    11101 gtatcgtgtg cttggcatta cccagcacct ttacatctac ggggacgttc ttaccgattt
    11161 ccgagttgtc gatatccaga tggataatct tggcttgctt agcgtatgtc tttaaatcgc
    11221 cagtcacacg gtcgtcgaaa cgcataccga tagcgatcaa tacatcacac tcattcgttt
    11281 tccggttcgg ccctacgttt ccatgcatac cgagcattcc cttgttcaat gggaaatcgg
    11341 ttggcaacgc agataagccc aataccgtag atccggcagg tatatcattc ttttggagaa
    11401 acgctttcaa ttcctcttcc gcaccgccta acaatactcc ctgcccgacc agacagaagg
    11461 gtttcttcgc ctcattgatt aaatcggcgg cggccttgat acgatcctta ttgatatccg
    11521 gctccggttg ataactacgt acgtaatcga ccttcttata ttcatattcc accaacccta
    11581 cttgcgcgtc cttcgctaaa tccagcacaa ctggacccgg acggcctgta gaagcgatat
    11641 aaaaagcacg agaaacagcc catgcgatct cctccggctt gcggatttga taagcccatt
    11701 tcgtgatcgg ttgcgtgatg ccaatcacgt cgacttcctg aaaagcatcg gttcccaaca
    11761 acggcgaggg tacttgaccg gcgattacga ccattggcgt actatccatc agcgcgtcag
    11821 cgatacccgt gatggtattc gtagcgcccg ggccggaagt aaccaacgtc actcctacct
    11881 tgccggatac acgggcatat ccttgagccg catgggtagc gccttgctcg tggcgcacca
    11941 atacatgcct caactggtcc ctataatcat ataaactgtc gtaaataggt atcgcctgtc
    12001 cgccgggata accgaagata gtatctactc cttcagcaat caacgctttc agcaaagctt
    12061 ccgaaccggt tatcttttgt ttctccataa gaaataacgt gtttaatgta tattattggc
    12121 tttaatcttc aacaatcctt acacctccct tatcggcgga gctaaccatc ttcccgtacg
    12181 ctctcaatgc tttcgagacc tcacgctgac gcgtcggcgg cgtaaaggct ttctttccac
    12241 gtgcttcttc cgctttacgg cgctcggcca actcctcgtc actcagccgc acgttgatgg
    12301 aacgttccgg gatattgatc tcgatgatat ccccgtctct caccagtccg atagcgccac
    12361 cggaagcggc ctcgggagag atatgcccga tagaaagacc ggacgtaccg ccactgaaac
    12421 gaccatccgt gatcaaggcg cactccttac ctaagtgacg gctctttata taagaggtag
    12481 gatataacat ctcttgcatt cccggccccc ctttcggacc ctcatacgtg atgacgacca
    12541 catcgcctga aatgaccttg cctcctaaaa tgccctcgca agcggcatcc tgtgaatcga
    12601 agactttcgc cgggccggag aatttccaaa tactctcatc cacaccggcg gtttttacga
    12661 cacatccgtc caaggcgata ttccctctca aaacagccaa gccgccatcc ttggaataag
    12721 cgtgctccac gtcacggata caaccttcgg cacgatccgt atctaattcc ttataataag
    12781 attcttggga gcccatctgt atactgaacc gatgagcggg agcgctcttg tatttacgaa
    12841 tcgcctcctc cgttacgttc ggggaagtga cggcgtattt atcaacagcc tcggccaagg
    12901 tcaggccgtc cgcacgtctc gtgctgccat ccacaagccc ggctttcatc aactcgttca
    12961 tgataccgag gattccaccg gcacggttta cgtcttgtac atgataagtg tgcgtattcg
    13021 gggctacctt acacaggcaa ggagtcttgc gggataacat atcgatatcc tccatatgaa
    13081 aatcggcgcc ggcttcttgt gccacggcca ataagtgaag cactgtattg gtagaccccc
    13141 ccatggcgat atccagcgac atggcgttca agaaagcctg acgggtagcg atgttgcgag
    13201 gtaacacgga atcatccccg tcacgatagt atttgtaagc gttctctacg atttgcttag
    13261 ccgcgtcacg gaaaagttgg atacggttct tatgggtagc cacgatcgtc ccgttacccg
    13321 gaagcgccag accgatcgcc tcgttcaagc agttcataga gttagcggta aacataccgg
    13381 aacaacaacc gcaacccgga cacgcatggc gttccacctg ctcgatacgc tcatcgctta
    13441 ccgatgtatc ggcagactca atcatcgcgt cgatcaaatc aagatggcgg ccatccagct
    13501 cacctgcctc catcgggcca ccggacacga acaccgtcgg gatatttaat cgcatggaag
    13561 ccataagcat acccggcgtg atcttatcgc aattgctgat gcaaaccata gcgtccgcct
    13621 tatgggcatt taccatatat tccacgctgt ccgcgataat gtcgcgtgaa ggaagcgagt
    13681 aaagcatccc atcgtgcccc atagcgatac cgtcgtcgat agcgatcgta ttaaattcag
    13741 cggcgaaaca accttgtttc tcgatctcgg ccttgaccaa ttgcccgacc tcatgcaaat
    13801 gcgtatgccc cggcacgaac tgggtaaatg aatttacgat agcgataata gcttgccgaa
    13861 ctgttcctct ttcatcccgt tggcacgcca tagcgcacgg gctccggcca tcctacgacc
    13921 ttcggtgcta aatgagcttc ttaacggatt cttcatctct ttcctatttt ttgttcgtag
    13981 agcgctttat ccacgcctct accttgattt atttataata aaaaagcctt tccctatatg
    14041 gagaaaggct taagaaatat ctctacgact tcacaacttc ttacacacct ttctccttac
    14101 ctactaatga ctagaaggac caccacgaga ataatatgca atacgttgtt catcatcttt
    14161 tcttattgtc tttgtttgtt tgacgctgca aatgtagaac aataattgat atgcgcaaag
    14221 gatttaaaag aaaattcttc atttttcttt caattctcaa gcaaacacca ttttaggatt
    14281 gcattttaac aggagcaaga gtgtattact taggaatcgg aaggtataga agggaaaaaa
    14341 cttcgatttc caaacagaaa cagtaaaaag acaaatatta tctaaaacgg attccagata
    14401 acatttttat cagataacac gacttacgat aacacgtatc tcataagaaa atcctattct
    14461 agcgataaaa aagatacata taaactctaa atcacatatt tattaacact tgtagactat
    14521 aaatagcctt gaaaaattca taatagtgtt ctagaaaaaa cataaggaag ttttctgaag
    14581 aacataagga agaaatttca tctagtatcg gactaaattt tgttaacatt cgaatgaaat
    14641 cacctaaaat caagactaaa tccggcatac cccacgctag aagcagctca agcaaagaca
    14701 ttttcaaaat gactttcaga cagagaaagc cttaaattac tcaaaaccga tagacag
//
