LOCUS       gnlProkkaNIMANOIA_192  14936 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NIMANOIA_192.
ACCESSION   gnlProkkaNIMANOIA_192
VERSION     gnlProkkaNIMANOIA_192
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 21:13:21
            Original ID  :: gnl|Prokka|NIMANOIA_192
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 31767
            Orig. end    :: 46703
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14936
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10345]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10345
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14936
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14936
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2007..3044
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg175_27"
                     /sec_met_domain="PF04055 (E-value: 3.4e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSID
                     EMTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERAT
                     LCISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDN
                     LEEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRA
                     ELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCR
                     INLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQE
                     ENNKS"
     CDS             3062..4099
                     /locus_tag="ctg175_28"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGSDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTKEA
                     EPTNK"
     CDS             4104..5198
                     /locus_tag="ctg175_29"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGDGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5322..6563
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg175_30"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6550..7077
                     /locus_tag="ctg175_31"
                     /transl_table=11
                     /translation="MNWIKKIARPLILIVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7082..7876
                     /locus_tag="ctg175_32"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVADEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLKEEEKAKAASSAETNETGRTDETTETNTVEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7907..8278
                     /locus_tag="ctg175_33"
                     /transl_table=11
                     /translation="MVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRKTTDFLEKA
                     TWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAPQTDATAPA
                     ESAPATEAPATETPAPAAE"
     CDS             complement(8306..8446)
                     /locus_tag="ctg175_34"
                     /transl_table=11
                     /translation="MKKSRPDPIIKTGANYTYYTILLESLVIRVIRAYNEENGSKSPFT
                     Q"
     CDS             8569..9957
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.3; E-value: 8.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg175_35"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10345
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg175_36"
                     /sec_met_domain="PF05402 (E-value: 1.5e-17, bitscore: 55.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 6.4e-10, bitscore:
                     30.2, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEREGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQHEAGYESRVSTYLSQLQ
                     KDGFIKWIID"
     CDS             10373..10627
                     /locus_tag="ctg175_37"
                     /transl_table=11
                     /translation="MRLSSWNIIPYVHYPLSIFHYPLKKDCPQEDSTSYQYAHNDERSP
                     YEIAVIFFFFLFRILDDAFHLFRSRIRQKIGVVVSSESP"
     CDS             complement(10743..11807)
                     /locus_tag="ctg175_38"
                     /transl_table=11
                     /translation="MKKFIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAIVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREEGK"
     CDS             complement(11881..12207)
                     /locus_tag="ctg175_39"
                     /transl_table=11
                     /translation="MKACELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGS
                     GDVLTGVILALLAQGYPAEDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWR
                     LVSE"
     CDS             complement(12207..12899)
                     /locus_tag="ctg175_40"
                     /transl_table=11
                     /translation="MGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLD
                     IQLSEEGIEETETNYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAA
                     RACLRSGVGLLTVHAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGL
                     GRSEETEAALIEQLEHCQTPTVVDADALNILANHRHTLTHLPKGPSSPLTRKSWNAWSA
                     NVRTHTND"
     CDS             complement(12899..13390)
                     /locus_tag="ctg175_41"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     "
     CDS             13970..14851
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 100; E-value: 3.5e-30)"
                     /gene_kind="other"
                     /locus_tag="ctg175_42"
                     /transl_table=11
                     /translation="MVRNAYQGVGSEYETLIKAFDKDCANFLKRVGKDRSIGTYKVMVR
                     ARNYVAAFIKSFYKRTDMSMLELTPDFIKEFAAYLTAERGLKNATIWLNCMWLKGVVMR
                     AHYNGLIPRNPFAQFHISPNVKEQEYLTEDEIKRIMAHEFDNPTLTLVRDLFIFACFTA
                     LSFVDMKELTTDEIVEVNGEKWILSKRHKTNVPFQVKLLDIPLQIIERYKYLSEDKLVF
                     GKINYWTMCKQLKKVMAECGIEKQISYHCARHTFGTLALSKGMPIESVSRVLGHTNIVT
                     TQIYASAPRMVA"
ORIGIN
        1 acgttaataa caaactggtt gagaaagaag caaaagcatt gggactgaca gtttctgctg
       61 ctgaaattca ggatatcctg aaagcaggcg tgcatccatt gttgcaacag actcctttcc
      121 gcaacccgca gaccggtgct ttcgataagg atatgctcaa taagttcctg gtagattacg
      181 ctaaaatgaa cgaatctcag atgccggctc agtatgcaga acagtacaac aacatgtaca
      241 aatactggtc attcatccag aagacattgg ttcagagtcg cctggcagag aaatatcagg
      301 cattggtggc aaaagcgctt ctctctaacc cggtagaagc acaggacgct ttcgacgcaa
      361 gagtgaatca atatgacttg ttgatggctg ccgttcctta ttcttctata gtagattcta
      421 caatcgttgt gaaagaatct gaactgaaag acctttataa caagaaaaaa gaacagttca
      481 agcaatatca ggaaagccgt gatatcaagt acattgatgt tcaggtgact gcaagtgcgg
      541 aagacagagc tgctatccag caggaagtag acgaagctac tgcacagctg gctactacaa
      601 cagatgacta tacttctttt atccgttctg taggttcgga agctccttat gtagacttgt
      661 tctataataa aacagctttc ccgtcagatg tagttgcccg tctggactct gcatccgttg
      721 gttctgttta tggtccgtac tataatggtg ccgacaatac tatcaattca ttcaaagtgg
      781 ttgcaaaaac agctgctgcc gactcaatcg agttccgtca gattcaggtg tttgcagaag
      841 acgctttgaa gacaaaagcc ttggcggaca gtatctatac tgctatcaaa ggcggtgcta
      901 acttcgcaga tctggctaag aaatacggtc agacgggtga gactaactgg atgagctctg
      961 cacagtatga aggcgcacag atcgatggtg acaacctgaa gtttatctct gctatcaata
     1021 atacaggcgt gaacgaagta gtaaacctgc cgttgggaca agctaatgta atcctgcaag
     1081 tgactaacaa gaaagctgtg aaggataaat ataaagtagc tgttgtgaaa cgtgaagttg
     1141 aattcagcaa agaaacttat aaccgtgctt acaatgactt cagccagttc atcgctgcca
     1201 atcctactgc tgaaaagatg atcgctaacg ctgaagaagc cggatacaaa ctgcttgaca
     1261 gaagagactt gtatagctca gaacacacta tcggtggtgt aagaggtact aaagaagcat
     1321 tgagatgggc gtttgccgct aaaccgggtg atgtttccgg tttgtatgaa tgtggcgaaa
     1381 gcgaccatat ggttgcagta gctctggttg gtgttactcc ggaaggatat cgtccgctga
     1441 aagctgtaca ggatcagttg agagctgaaa tcgttaaaga taagaaagcc gaaaagatca
     1501 tggctgacat gaaggctgcc aatgcaactt ctctcgacca gtacaaggct atgtccggcg
     1561 cagtcagcga ttctttgaag ctggttacat ttgccgctcc cgcttatgtc tctgaattgc
     1621 gcagcagcga accgctggta ggtgcatatg cttctgtggc tgaaatgaac aaactgagcg
     1681 ctccgatcaa aggtaatgcc ggtgtatttg tgcttcagat gtatggcaaa gacaaactga
     1741 gcgatacttt caacgctaaa gatgaagaag ctacattggc taacatgcac gcacgcttcg
     1801 caagccgtct gatgaacgac ctgtatctga aaggaaaagt gaaggataca cgttacctgt
     1861 tcttctaaga ttagttataa aaacgataac tgcaaaaggt cgttccatgc tttggaacga
     1921 ccttttttgc taacttttac atccttgcta tacggaaatc gactttattt ccttacattt
     1981 gcaaatataa accatgaaca gaaagaatga tgtctaaata tcccctctta ggaatgacgc
     2041 ttatagagct gcagtcactg gtgaaacgtc tgggaatgcc gggctttgca gccaaacaga
     2101 ttgcatcctg gctttatgat aagaaggtga cttcgattga tgaaatgact aacttgtcgt
     2161 tgaaataccg ggagttactg aagcagaact atgaggtagg agctgaagca ccggtggagg
     2221 aaatgcgctc tgtagacggt acggtgaaat acctgtaccc tgtgggtgag aatcattttg
     2281 tggagtcggt gtatattccg gatgatgaac gggcgacttt atgcatctct tcgcaggtag
     2341 gctgcaaaat gaactgcaag ttctgtatga ccgggaaaca aggctactct gccaacctga
     2401 ccgcccatca gattatcaat cagattcact ccttgccgga acgggacaaa ctgacgaatg
     2461 tcgtcatgat gggaatgggc gaaccgctcg ataatctgga agaggtgttg aaggcattgg
     2521 acatactgac tggatcctat ggttatgcat ggagtccgaa gcggattacc gtttcaactg
     2581 tcggattgcg gaaaggattg cggcgcttta tcgaagaaag cgactgtcat cttgccatca
     2641 gcctgcattc tccggtgacc gcccagcgtg cggaactgat gccggcggag aaagcctttt
     2701 ctatcacgga aatggtggaa ctgttaaaaa actatgattt tagcaaacag cgtcgacttt
     2761 cgtttgagta tattgttttt aaggggctta atgattcgca agtttatgcc aaggagttac
     2821 tcaaactgct tcgcggactg gattgccgga ttaacctgat ccgtttccat tctattccgg
     2881 gagtagccct tgaaggagcc gatatggata cgatgacccg tttccgtgac tatctgacca
     2941 cgcacgggct tttcactacc attcgtgctt cgcggggaga ggatattttt gcggcatgcg
     3001 gtatgctgtc gactgcgaaa caggaggaaa ataataaaag ttaatataaa aatcgaacat
     3061 catgaaaaag tacttttttt atttaagcat ggctctggta gccttcgtag ttgcttcttg
     3121 tggattaaag gggaatcata cctctagcgg tcgtccgtat gaactgttgg ttgtagtaga
     3181 tgcgggagtg tgggaccgtg ccgccggaag ggccttgcat gatgtgcttg attctgacat
     3241 gccgggactg ccccagtcgg aaccttcttt ccggattatg tatacttcac cgaaggacta
     3301 tgattctacg ctgaagttga tccgtaatat tgtgatagta gatataaaag atatttatac
     3361 caaaggtact ttcaagtatg cgaaagacgt ttatgcttct ccacagatga tactgaccat
     3421 tcaggctccg aacgaagaag tgtttgagaa gtttgtggaa gaaaataagc agacgattat
     3481 cgacttcttc actcgcgctg aaatgaaccg tcagattact ttgctggagg aaaagcacaa
     3541 caactttatc tcaaataagg tagatagtct gtttggctcc gatatctgga taccttccga
     3601 actgaataac tccaagacag gagaggactt cttctgggca tctaccaata caggcagcgc
     3661 ggatcgcaat ttcgtgatgt attcttatcc ttatactgac aaggatacat tcaccaaaga
     3721 atactttgtt cataagcgcg attccgtgat gaaagccaat atccccggat ataaagaagg
     3781 cgtatatatg tcgacagact cgttactgac cgatgttcgt ccgatcaacg tgcacaatga
     3841 ctacacgatg gaagctcgtg gattgtggcg catgaagggt gacttcatgg gtggcccgtt
     3901 cgtttcccat actcgtctgg atcagaagaa ccaacgtatt attacagcag aaatatttgt
     3961 atattcaccc gataaaatga aacgcaatct ggttcgccag atggaagcat ctctttatac
     4021 gctgaaactt ccgcaagaag gtcagcagag ccagattcca ctgggggtaa ccaaagaagc
     4081 ggaaccaact aataaataaa aacatggaag aaaacaaaat aagaatcggc attacccaag
     4141 gagatatcaa cggggtaggt tatgaagtga tcttgaagac attctcagac cctaccatgc
     4201 ttgagctatg tactccgatt atctacggtt cacctaaagt agcggcttac catcgtaaag
     4261 cactggatgt acaggctaat ttcagcattg tcaacactgc ttccgaagcc ggatacaacc
     4321 gtctgagtgt agtgaactgt acggatgacg aagtgaaagt ggaattctcc aaacccgatc
     4381 ccgaagcagg taaggctgca ttgggtgctt tagaacgtgc catagaagag tatcgtgagg
     4441 ggctgatcga cgtcattgtg acagctccga tcaacaaaca taccattcag tcggaagagt
     4501 tctctttccc cggtcatacg gagtatattg aagaacgtct gggcgatgga aacaagtcac
     4561 tgatgatcct gatgaaaaac gattttcgtg tggctttagt aacgacgcat attccggtaa
     4621 gggagattgc tacaacaatc accaaggaac tgattcagga aaagctgatg attttccatc
     4681 gttgcctgaa acaggatttc ggtatcggtg cgccccgtat tgcagtgctt tcactgaatc
     4741 ctcatgcagg agacggcgga ctgctgggta tggaagaaca ggaaatcatt atccctgcca
     4801 tgaaagaaat ggaagagaaa gggatcatct gttacggtcc ttatgctgcg gacggtttta
     4861 tgggttcggg caattatact cactttgacg gaatccttgc tatgtatcat gatcagggac
     4921 tggctccgtt caaagccctg gctatggaag acggtgtgaa ctataccgcc ggactgccgg
     4981 ttgtacgtac ctctccggcc catggaacag cttatgacat cgccggtaaa ggactggcca
     5041 gcgaagactc tttccgccag gctatttatg tagcgattga tgtattccgc aaccgccagc
     5101 gcgagaaagc ggcacgggta aacccgttgc ggaagcagta ttacgagaaa cgggacgata
     5161 gtgataaact aaaactggat acagtagacg aagattaagt aataggtatt aagtaataag
     5221 tattaagtat tagccttgcg gatggaagcg agatgatcat gatggtaata cttaatactt
     5281 attacttaat acttattacc tattacttaa tattaagata gatgaccaaa gcggagatac
     5341 aacaagtgaa acagcgtttc ggtattattg gcaataccga ggctttatca cgtgccatag
     5401 atgttgccat tcaggtagcg cctaccgatt tgtctgtgct gattaccgga gaaagtggtg
     5461 tcggaaaaga aagttttcca cagatcattc atcaatatag ccggagaaag cacggacagt
     5521 atattgctgt caactgcggt gccataccgg aaggtacgat cgattccgaa ctgttcggac
     5581 acgagaaagg agcatttacc ggtgctattg gtgagcggaa aggatatttt ggagaagctg
     5641 acggtggaac catcttcctt gatgaagtgg gagagttgcc gttgcctaca caggcgcgtc
     5701 tgctccgtgt acttgaaagc ggtgaattta tcaaggtagg ttcatccaaa gtgcaaaaga
     5761 cggatgtacg tattgtggca gctaccaacg tgaacctgac acaagccatt gccgaaggac
     5821 gcttccggga agatttgtat tatcggttga acacggtgcc tattcagata ccacctttgc
     5881 gtgagcgcgg agatgatgtg ctgttgttgt tccgtaagtt tgccgcagac tttgccgaaa
     5941 agtaccggat gccggctatc cagctgacgg aagatgccaa gaagatattg cttgcttatc
     6001 cgtggccggg aaacgtccgg cagttgaaga acatcacaga gcagatttcg attatagaaa
     6061 caaaccgtga gataacggct gcgattctgc agacctatct tccggcacag aatacccaac
     6121 gccttccggc actgttcggc acacgcgaga gcaagagctt tgagagcgaa cgcgaaatac
     6181 tatattctgt cttgttcgat atgcgtcagg aggtggcgga actgaagaag atggtgcaca
     6241 acatgatggc cgaacgtgcg ggacaagtcg gacagatggg acaggtagtg gctactccgg
     6301 tagtgacgac gacgcaccaa ccatccgtgc cggccattat ccatgctgtg cagcaaccgt
     6361 ctgtttgtcc caaagaagac gatgacgaca ttcaggacac ggaagagtat gtggaagaaa
     6421 ccctttcgct cgatgaagtg gaaaaagaaa tgatacgtaa agcgcttgag aggcatcatg
     6481 gtaagcggaa aagtgcggcg aaggatctga atatctccga gcgtaccctt tacagaaaaa
     6541 taaaagaata tgaattggat taagaaaata gcacgaccgc tgatactgat tgttttaccg
     6601 gcagtcatca tcgcctgtag tgtgtcctat aagtttaatg gctcctctat caattacgat
     6661 aaggtgaaga ccatttcgat tgctgatttc ccgattaagt cggagtatgt gtatgctccg
     6721 ctggctacca agttcaatga agacctgaaa gatatcttca tcagacagac ccgtctgcaa
     6781 ttgctgaaac cgaaccagaa tgcggatctg cagattgacg gtgaaattac gggctacaac
     6841 cagtataacc aggcagtgtc tgccgatggt tactcttcgg aaacgaagct gaccatcacg
     6901 gtcaatgtac gctttgtcaa caacacaaat cacgccgaag acttcgaaca acaattctca
     6961 gctttccgta cctatgattc tagccagctg ctgacagccg tacaggatgg attaatagcg
     7021 gaaatgagta aagagataac cgaccaaata tttaatgcaa ctgtagcaaa ctggtaattt
     7081 aatgacttct gttaacttgc aacaatggat tcagcatccc gagacgctga atagggatac
     7141 tttgtacgaa ctgcgcaacc agctcgcaag gtatccgtat tttcagtcgc tccggttgtt
     7201 gtatctcaag aacctgtata ttctccacga cattaatttc ggtgcggaac tgcggaaagc
     7261 cgttctgtat attgccgacc gacggaaact gtttcatctg atcgaaggcg aacgcttcgc
     7321 tgtcgaatcc cagaagaaag ggctgcctct ctctgaagta ttgaaagatg agcctaccgt
     7381 cgaccggaca ctggctctga tcgatgcttt cctttcgacg gctcccgaag aagtaaccag
     7441 tcagacaagc tttgattact ccatggacta tacggcatac cttctcgaag agacacctgt
     7501 cgccgacgag ccggcagagg caatgcccaa gctgaaagga cacgagctga ttgacaactt
     7561 tatcgaaaaa agcgagactg atccagtcgt atatctgaaa cctttgaagg aagaagagaa
     7621 agcaaaggca gcttcttccg ctgaaacaaa cgaaacgggc agaacagacg aaacaactga
     7681 aaccaacacc gtagaagagg aagatgacag ctgtttcaca gaaactttgg ccaaaatcta
     7741 cgtaaaacag caacgatatt cgaaagctct tgaaataatt aaaaaattaa gcttgaaata
     7801 tccaaaaaaa aatgcttact ttgcagacca aatcagattt ttggagaaat tgattattaa
     7861 cgctaattca aaataactaa aaatgtactt attattcatt atcttaatgg tgattgcagc
     7921 cttgctgatg tgcttcatcg tgctgattca gaattcaaaa ggaggcggac ttgcttctgg
     7981 tttttcttca tcaaacgcta tcatgggcgt gcgcaagact acagattttc tggaaaaagc
     8041 aacttggggt ctggctatct tcatggttgt gatgagcgtt gctactgctt acgttgttcc
     8101 ttcttcttct gcagctaaag atgtattgtt ggaacaagca cagaaagaac aacaaaccaa
     8161 cccgtataat atgcctaccg gtactgctgc tcctcagaca gacgctactg ctcctgcaga
     8221 gtctgcacca gcaacagaag ctccggctac tgaaactcct gctcctgcag cagaataatt
     8281 cagtgacagg atattcggtt taaacttatt gagtgaatgg gctttttgac ccgttctctt
     8341 cattataggc gcgaattacg cgaattacaa gagattctaa tagaatcgtg taatacgtgt
     8401 agttcgcgcc tgtctttatt attgggtccg gtctgctctt cttcatacag gaatatccgg
     8461 ttagatgtcc tttttcttat aaaatgttct ccttttttag taaaacaaat gataattagt
     8521 taactttgtt gcccgttacg agattattaa ctccttttaa atattacaat gacagaacaa
     8581 ttgaaacaaa agctgaatga ctccgcagtg ctgcgttgga gtgttctagc attagtcgct
     8641 tttaccatgt tgtgcggcta cttcctcaca gacgttatgt ctcctctgaa acccatgctt
     8701 gaaaaagaac ttctctggga cagtttagat tacggttttt tcaccagtgc ttatggctgg
     8761 tttaatgtat tcctgctgat gctcatcttt ggtggtatca ttctggataa gatgggagta
     8821 cgcttcaccg gaatgggtgc ctgtttattg atggtgttcg gttgtggatt gaaatattat
     8881 gctattacta ctactttccc ggaaggtgcg atgcttttcg gattcaagat gcaagtcaca
     8941 ttggctgcat tgggttatgc catctttggt gtaggagtcg aaattgcggg tatcaccgtt
     9001 tcgaagatta tcgtgaagtg gtttaaaggc aaagagatgg ctctcgctat gggactggaa
     9061 atggcgaccg cgcgtattgg aacaactttg gccatggtgc ttaccgttcc tttggcagac
     9121 ttcttcgggt ctacggatga gagcggcgta ttccatacca atattcccgc tccgattctg
     9181 ttctgtctcg tcatgctgtg cgtaggtacc atcgcattct tcatctatac tttctatgat
     9241 aagaaactgg atgcttcact ggatgcggaa ggactggaac cggaagaacc tttccgcatg
     9301 aaagacatcg tatatatcat taccaacaaa ggattctggc tgatcgcatt actgtgcgta
     9361 ttgttctatt cggctgtatt ccccttcatc aagtatgcgg ctgatttgat ggtacagaag
     9421 tacaatgtag atccgaaact tgcgggaacg attcccggat tgctgccgat tggcgcgatc
     9481 atcctgacac cgttgttcgg gtcattgtat gaccgtatcg gtaagggagc cacgctgatg
     9541 gtgatcgggt cggtgatgct gattttcgta cacacgatgt tcgctcttcc tattctgaat
     9601 atatggtggt ttgcaacggt gatcatgatt attctgggat ttgctttctc attggttcct
     9661 tcggcaatgt ggccttcggt tccgaagatt attccggaga aacagttggg aacggcttat
     9721 gcgttgatct tttgggtaca gaactgggga ttgatgggcg tgcctttgct gatcggatgg
     9781 gtgttgaact cttattgcaa aggtccggtt gtagatggtg cacagactta tgattatacc
     9841 ctgccgatgg ctatttttgc tatgttcggt gtacttgccc tgattgttgc cttgatgctg
     9901 aaagcagaaa acaagaagaa aggctacgga ctggaagagg caaatattca gaaataatcc
     9961 agtatatatt ctatctgaaa agatataaaa gagaaaagat atggctacga aagagaaaat
    10021 aaacctcctg gaggtgatcc cttgtcgtaa cgaacatatt aaagctgaac gggaagggga
    10081 gactattgtg ctctcctttc ctcgttttaa acgttcgtgg atgagtcgtt atttattgcc
    10141 gaaaggaatg tccaaagata ttcatgtgcg tctggaagaa catggtacgg ccgtatggaa
    10201 cctgatagac ggccagcgga cggttcgtga gattatagaa aaactcgcag accactttca
    10261 acatgaagca ggctacgagt ctcgtgtatc tacttatctt tcccaattac agaaagacgg
    10321 atttattaaa tggataattg attaatggat aattgataat ggaaaatgga taatgaggtt
    10381 gagcagctgg aatattatcc catacgttca ttatccatta tcaattttcc attatccatt
    10441 aaaaaaagat tgcccacagg aggacagcac atcctatcag tacgcccata atgatgagcg
    10501 ttccccatac gaaatagctg ttatcttttt cttttttctt ttccgaatcc ttgatgatgc
    10561 gttccatctc ttccggagtc gtatccggca gaagataggg gtcgttgttt cttctgagtc
    10621 gccctaactt gtcatttctc cgttcacggc gtaagcggga ggcttctttg ccgtctttca
    10681 gccgacgtat catgtcgagc atatgtcctt cgccacccat agttttgttt tttttagagg
    10741 ttttatttgc cttcttctct atctactttc agtagtccac cggtcaccgg atcaaagtaa
    10801 actttgatgg ttgagttctt gttgaataat accggagcaa ggtattctat gataccgaat
    10861 tgggtaacag gtatttctcc ttcatacaat ttctttttgc cgtccgtcag cgtcactatt
    10921 gcctgtcccg gtacgttata agcaatacct tccatctctt tcttcttttt cccgtcctct
    10981 tgcggaatct tcaccgtttt caggtctttc agactgatgt agaatggagt gcctgccaaa
    11041 tcgttgttgg caactatacc cagcttcttt gaaaagcgga aggctacctc attgtcgaat
    11101 tctttatccg gagtgaggcg gacagtaaat gtcttttctt ctttattgcg gactcccgaa
    11161 aacatctcgg tcatggcttc ttcctgaaga ttcaggttgt cgagcatgat tttgagctgt
    11221 gcgccgtccg aaggcatatt atctgcttgt ccgcgcaata atgcgttttt actttcgcgg
    11281 atattataga tttcctttgc taccaattcg gccatcttgg cggtggaact tgccatcaga
    11341 atttcttctg tgagaaagtc gcggggattg gcttttcgtt ggggagcaac ggcattgttt
    11401 gctgcattct ttgcattgtt gctgctgtag gggacgttga tcgatttgat aagaccctct
    11461 tcagtcagtt ccataagagg agctacggtt ttgtctttca gtttgacgaa ataagtagct
    11521 tcgctgtttg gtacacctac aggtttcact ttgacactgt tcagttccca gtattcttcg
    11581 ggttcggcag agacgttggt cagtctcagg tagcggtcgg cgtatttgct gaattcaccc
    11641 ggcttatagt tgactttgtt tgcttttatt tctatttcta tctgggtttt ggggagggcg
    11701 tacactactc cgtagtcttt tcctcgcgtc actcctgtca gcacttcggt ctgcgcatag
    11761 gcggaagttg ccattagtag tcctgttgct atgataaact ttttcatatt cggttctttt
    11821 tagctgattt tgaaaaacaa agttaatgaa gttattgaat aaaccgtaag ttcttaactt
    11881 ttattcgctt acaagtcgcc atgccgtcgg cagacaagtc acgatatcac ttgcgattaa
    11941 tccgatcatg ccctgttttt tctgggcgat gtctccggcc aatccgtgaa tgtaagtacc
    12001 gatctttgcg gcgtcttcgg cgggatagcc ttgcgcaagg agtgcaagga ttactcctgt
    12061 cagtacatct ccgctgcctc ctgttgccat accgggatta ccggtctggt tgaagtaaca
    12121 tttgccttcg ggggtgataa tggcggaata agctcccttc agaatgatat gtactttggc
    12181 agtgtgcgcc agttcgcagg ctttcatcag tcgttcgtat gagtcctgac atttgccgac
    12241 caggcgttcc agctctttcg ggtgaggggt gaggatggac ctttcggcag atgggtgagc
    12301 gtatgccggt gattggccag aatattgagt gcgtcggcat ccactacggt cggagtctga
    12361 caatgttcca gttgttctat caaggcagct tccgtttctt cgctgcgacc gagtcccgga
    12421 ccgatgccga cagcttgata atcatccgta tcggtaggta cggcaaagca tgtttcgctg
    12481 acatctgttt ctaccatggc ttcgggggca gacgtttgca gaatatcgtt gttgcataac
    12541 ggcgcgtgta cggtcagcag acctactccc gagcgcagac aggcacgggc ggccagtacc
    12601 gatgcacctg ccattccttt cgaaccggct atcaacaggg catgtccgaa gtttccttta
    12661 tgggcgaatt gctggcgtgg cttgatcagc gaacggattt cttcgatttc cagcatttcg
    12721 tagtttgttt cagtctcttc gattccttct tcgctcagct ggatgtccaa taactcccat
    12781 tcgccaacaa attctgtatt ttcggcgaag aggaaggcca gtttaggaag ttgcaggctg
    12841 aaagtgacgt ccgcacggat aatattgctt tttacattga atgtattttc ttctcccatc
    12901 agccggaagg aatgtcgatg gagactacca tggcgggaga ggcattgata tatttcacga
    12961 cggcagcgaa tcctccgctc agtggtttgt tgagtccgga accgaataat ccgtcgatca
    13021 cgagatgctc cggtgtcagt gtgggaggga cgaactgggt gctgatttca tggaaagtta
    13081 cttcttccat catctctacc agttctttgt tggtctgaca gtcgggcgaa agttcgcctt
    13141 tcgtgttgaa gagatatact tcgatcttgt atcctttttc cgccatcatg cgggcgatgg
    13201 cgagggcgtc tccgccatta ttgcccggtc cggcaaagat ggtgacaggt gtttccggat
    13261 tccatctgtt ggtgatggct ttagtcagcg cctgtgcggc acgttccatt aaatctatgg
    13321 atgcaatcgg ttcatgttca atggtatagg catctaactt cttaatgctg ctgcttggaa
    13381 atattttcat tgcgatattc ttttagtttt cgacgcacaa acttacataa aatctctgga
    13441 ataacctcga aaaacgggag aaatgacgct aaacgactta atatcagagt tgttacggtg
    13501 tcaaatgatg acaagccgaa aaatcggaaa acgcaaagaa aagcggattt aagaagaaga
    13561 atggtttgca aatcattacc cgtgaaagag taagatttaa catatgagag atgctattgc
    13621 accgtttgtc accgatttgc gtatcaaggt ctaactcgtt gatatttaac tttgcaaaca
    13681 aaaaacgagt atggcaagaa gtacattcaa agtgctgttc tacgtgaacg gcagcaagga
    13741 gaaagacggt attgtcccca tcatgggacg agtgacaatc aacggtactg tggcgcagtt
    13801 cagttgcaag cagaccatcc cgaaaaccct ttgggatgcg aaaggcaacc gagccaaagg
    13861 caagagcgcc gaagcacgga acatcaatct ggcattggac aacatcaagg cgcaaatcat
    13921 caagcactat cagcgcatat ccgaccgaga ggcatacgta acggctgaaa tggtgcgcaa
    13981 tgcctaccaa ggggtaggaa gcgagtatga gacactgata aaggcttttg acaaggattg
    14041 cgccaacttt ctgaaacgtg tcggtaaaga ccgcagcatc ggcacgtaca aggtcatggt
    14101 aagggcaagg aactatgtcg cagcctttat caagtcattc tacaaacgga cagacatgtc
    14161 catgctggaa cttacacccg acttcatcaa ggagtttgcg gcttatctta cggctgaacg
    14221 gggactgaaa aacgccacca tttggctgaa ctgcatgtgg ctgaaaggcg tggtcatgcg
    14281 tgcgcactat aacggactga taccgagaaa tccgtttgcg cagttccata tcagcccgaa
    14341 tgttaaggaa caggagtatc tgacagagga cgaaatcaaa agaatcatgg cgcacgagtt
    14401 tgacaacccc accctcacat tggtgcggga tctgttcatt ttcgcctgct tcaccgcctt
    14461 gtctttcgtg gatatgaaag aactcacaac ggacgaaata gtggaggtga acggtgagaa
    14521 atggatattg tcgaaacggc acaagacaaa tgtcccgttc caagtgaagc tgctggatat
    14581 tcccttgcag ataatcgaac ggtacaagta tctgtcggaa gacaagctag ttttcgggaa
    14641 aatcaactat tggacgatgt gcaaacaact gaaaaaggta atggcggaat gcggaataga
    14701 gaagcaaatc tcctaccatt gcgcacgtca tacgtttgga acactggctc ttagcaaggg
    14761 gatgcccatt gaaagcgtga gccgtgttct gggacacacg aacattgtca cgactcaaat
    14821 ctatgcgagt gcgcccagaa tggtcgctta ataaatactt ctttagcaag aagttaggat
    14881 tgggttcgat ataatcctat cgtcaatcag tttatccaaa ggggaaaccc gatggg
//
