LOCUS       c00129_gnlPro..        16667 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHJEEDLC_141.
ACCESSION   c00129_gnlPro..
VERSION     c00129_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:40:05
            Original ID  :: gnl|Prokka|HHJEEDLC_141
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16667
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16667
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3189:6747](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3190..6747
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16667
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16667
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(617..1771)
                     /locus_tag="ctg129_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTFPQ"
     CDS             1951..3156
                     /locus_tag="ctg129_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3190..6747
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_3"
                     /sec_met_domain="PFOR_II (E-value: 5.4e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.7e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 8.5e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.8e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 5e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.7e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.3e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6872..7060
                     /locus_tag="ctg129_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(7071..7688)
                     /locus_tag="ctg129_5"
                     /transl_table=11
                     /translation="MDVWMPVTMEDYMKQYGDKLEVIGDIYDGARIGLVVPDYVTINSI
                     EELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLDYKLMTSSGPAMTASLKKAIDKK
                     DWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHTIAWKGFSEKDPFAAELLGNIRL
                     TDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSWIPEKD"
     CDS             complement(7837..7929)
                     /locus_tag="ctg129_6"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVPAETTERVRR"
     CDS             complement(7957..8787)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg129_7"
                     /sec_met_domain="BPD_transp_1 (E-value: 3.1e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8784..10010)
                     /locus_tag="ctg129_8"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10483..11769
                     /locus_tag="ctg129_9"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSTGAYDSFFYARP
                     IAVWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11732..12064)
                     /locus_tag="ctg129_10"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGVPQ
                     CSRMVGRALKEVPDELSIPCHRVVNTAGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12092..14845)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg129_11"
                     /sec_met_domain="Peripla_BP_1 (E-value: 8.1e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFCLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAIRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKSSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15178..16404)
                     /locus_tag="ctg129_12"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 acataggaat aagaataaca aaagtaaacc tatttagata ttaaagtata ttgagtaaac
       61 taattcagtt ataacaaacg aagttgtcaa ctaaaaccag tacacatcat ttagcagtat
      121 cttcaaagag tttccattgc ttgaaaccag agtttcatcg gtgtgaaact gtagtttcat
      181 cggtgagaaa ctagagtttc atacgcttga aactttagtt ccaaacgctc gaaactatct
      241 gaaactactg ttgatttgat tgacttaacc gcatgttcca atcacattga acgcatcagc
      301 tacttcaata gtactgctct ctctgaaaac attaaatcat atatcagtca ataatacata
      361 aattatcagt ccttaatact tgatttctca attattaata tctgagaaat caaacgttaa
      421 cagttgagat atcagatatt aacatcctgt aaatcaaaga ataacacagt aaaaacggta
      481 tttatcagga cgatgcagag tgagagcaag tccttgctct cactctgcta ccactggatc
      541 tctaacagct aaaacatcga tgaataaagg gatacagacg aactgttaga gcatgagagc
      601 aaaagcacta tctttttcac tgggggaaag taagcaaaag aaacgcacga taccggcttt
      661 gaggcgtcac cggtactaac ggcaaatatc cggcacacac ccgattattc tctacggaca
      721 aagggaacga agccgacatc tgccgatgtt cctccaaagc ctgaccggct aaaggataat
      781 aatcaatccg aaaaactcct tccgcatccg cagccaaata acgatccgtc aagagccatg
      841 ccaccacccc catattcatt cgcagattaa tttcgacaca aggatgaatc cggtaaacag
      901 gcgcttcatc cggaaaatga caaatcatca tatccactcc caagtatcca tgataaaagc
      961 caccgaacaa agctgacaat tcttcttcca aacgagtccg cagcctgata aattcttctt
     1021 gtggcacata agccgatagt ttctgcagaa tcttctcgtc agacagcaag tcattccctg
     1081 catacatccc actcccaccc gtgtggaaga ccgaatatcc ggcaaaaaca acccttcctc
     1141 tcccgtcagc ataaaactcc atagcgaaat cttccacctt attatatata ggttcgccta
     1201 ccaccccacc ctgagaagca gcgacacggg cacaccaacc ggaaataaaa gtagtaaata
     1261 tgcctttaca ccaattcaat cctttcccgc ttccggaaag cggagctttt aacaagcacg
     1321 cttcccgccc ttcgacgaac gcactgcact ccgccaaagt actcaaataa aaagattctc
     1381 cacagaagta ttcattcaac cgcaacccag gcaacaactt taccgcctgc agacgatgcg
     1441 aatgctctct cagaatattc atataatccg cagaaggcag ctccgtctga tctgccccca
     1501 atgtcatcaa acgcttccgc aaagcagggt cccaccccca cggagagaac ttccggtctt
     1561 taccgtcagc cacttccggt tccgtcaaca aggccacatc catgcccaaa agttcactct
     1621 ttgttttcag gaagtccgca ttataagcag acggtgcaag caccgcactt cccgcttcgg
     1681 cataccacat aggaagcaac gccaggtcac tcgccatctg tcgggcggaa gccggcgcca
     1741 tatagttcgt ctcaccgctt gccaacgcca tatcatgctc cggattgaat atataaacag
     1801 gtcttttcgt catgtcaaag atggattcaa cacattattc tgcaaatata tacaggaaat
     1861 aatcaggaac ttacacaata aagagaaact tataaattaa agcacatttt tgctatctct
     1921 actttgcaaa tcctaaaaaa agcactatat ttgccagccg aaaaacaaag aaacgaaatg
     1981 gaatcattct atcgcacaca cgcctacctc gttgagcaca ccaatgcccc cgttcgccgc
     2041 gatcttatgg acgagatcga ctggagtgac cgtctgattg gtatcaaagg gacacgtggc
     2101 gtaggaaaaa ccactttcct cctgcagtac gccaaagaga aattcggcac cgaccgttcc
     2161 tgtctgttca tcaatatgaa caacttttat ttctccggtc acagccttgt tgacttcgcc
     2221 aacgagtttc agaaacgtgg cggaaaagta ctgctgatcg accaggtgtt caaacatccc
     2281 gaatggagca aagagctacg aatgtgctat gaccgtttcc ccagcctgaa gattgtcttc
     2341 accggttctt ccgtcatgcg actcaaagag gaaaacctcg aattgcgtga cattgcgaaa
     2401 agttataacc tgcgcggatt ctctttccgt gaatttctga acctgcagac aggaatgaaa
     2461 ttccgggcat acagcctcga agaaatcctc agtacacatg aacagatagc caaaggagta
     2521 ctttccaaag tacgaccgct ggattatttt caggattacc tgcatcatgg tttctaccct
     2581 ttcttccttg aaaaacgtaa tttctcggag aatctgctga aaacaatgaa catgatggta
     2641 gaagtggata tcttgctgat caaacaaatt gagctgaaat atctttcaaa gataaaaaaa
     2701 ttactatatt tgttggctgt ggacggaccg aaagctccga acgtgagcca actggcaagt
     2761 gacgtacaga catcccgcgc tacggtaatg aactatatca agtatctggc agacgcgcgt
     2821 ctgattaatc tggtttaccc gaaaggagaa gaattcccaa agaaaccgtc aaagattatg
     2881 atgcacaact ctaacctgat gtactccatt tatccggtga aagtggaaga acaggatgta
     2941 ctcgacacgt tcttcgttaa cactttatgg aaagaccata aggtacataa aggagataaa
     3001 aacgtctctt tcatggtaga cgaagtgatg ccgttcaaaa tttgtgcgga aggtacaaaa
     3061 ataaagaata acccggacgt gacgtatgcg ttgcaaaagg ctgagatagg ccgcggcaac
     3121 caaatacctc tctggatgtt cggattctta tactaaaaag atttatttac ttaaatattt
     3181 aatttagtta tgactaaaca gaagaaattc atcacatgtg atggtaacca agctgcagca
     3241 catatctcgt atatgttctc tgaagtagca gctatctacc ccatcactcc ttcttcgact
     3301 atggctgagt acgtagacga atgggctgcc gcaggacgta agaacatctt cggcgaaaca
     3361 gtattggtac aggaaatgca atctgaaggt ggtgctgccg gtgcagttca cggttctctt
     3421 caggctggtg cattgactac tacttacact gcttctcagg gtcttctttt gatgatccct
     3481 aacatgtaca agattgccgg tgaattcttg ccttgtgtat tccacgtttc tgctcgtaca
     3541 ctggcttctc acgcattgtg tatcttcggt gaccatcagg acgtaatgtc agctcgtcaa
     3601 accggcttcg ctatgttggc agaaggttct gtacaggaag ttatggattt ggcaggtgtt
     3661 gctcatctgg ctactatcaa atcacgcgtt ccgttcatga acttcttcga tggtttccgt
     3721 acttctcacg aaatccagaa gatcgaaatg ttggaaaacg acgacctcgc tccgctgatc
     3781 gaccaggaag ctttggctga attccgtgcc cgtgcactga atccgatgaa gccggttgcc
     3841 cgtggtatgg ctgaaaaccc cgaccacttc ttccaacatc gtgaatcatg caataactac
     3901 tatgaagcag ttcctgctat cgtagaagaa tacatgaacg aaatttccaa gatcacaggc
     3961 cgcaaatacg gtttgttcga ttactacggt gcagaagatg cagaacgcgt aattatcgca
     4021 atgggttctg taactgaagc tgcccgcgaa gctatcgacc acttggtagc aaacggcgaa
     4081 aaagtaggta tggttgccgt acacttgtat cgtccgttct ctgctaaaca cttcctggct
     4141 gctgtaccca agactgcaaa gagcatcgca gtgcttgacc gtacaaaaga accgggtgct
     4201 aacggcgaac ctctttacct tgacgttaaa gactgcttct atggcgcaga aaatgctcct
     4261 gttatcgttg gcggtcgcta cggtctgggt tcaaaagata ccactccggc acagatcatc
     4321 tctgtattcg aaaacttggc tatgccaatg ccgaagaacc acttcactat cggtatcgta
     4381 gacgacgtta cgttcacttc tcttcctcag aaagaagaaa tcgctctggg cggtgaaggt
     4441 atgttcgaag ctaaattcta cggtctgggt gctgacggta cagtaggtgc caacaagaac
     4501 tctgttaaga ttatcggtga caacaccgac aaacactgtc aggcttactt ctcttacgac
     4561 tccaagaagt cgggtggttt cacttgttct cacttgcgtt tcggtgatac tccgatccgt
     4621 tctacttact tggtaaatac tccgaacttc gttgcttgtc acgttcaggc ttacctgcac
     4681 atgtacgacg taacacgtgg tttgcgtaag aacggttctt tcttgctgaa caccatctgg
     4741 gaaggcgaag aactggctaa gaacctgcct aacaaggtga agaaatactt tgcacagaac
     4801 aacatctctg tatactatat caacgcaact cagattgcaa tggaaattgg tttgggcaac
     4861 cgtaccaata caatccttca gtctgcattc ttccgtatca caggcgtaat ccctgtagat
     4921 caagctgttg aacagatgaa gaaattcatc gttaagtctt acggcaagaa gggtgaagac
     4981 gttgttaaca agaactacgc tgctgtagac cgcggtggtg aatacaagac tctgactgtc
     5041 gatcctgctt gggctaacct gccggatgat gcaaaagcag aaaacaatga tcctgctttc
     5101 atcaacgaag tagttcgtcc gatcaatgca caggacggtg acttgctgcc ggtatctgca
     5161 ttcaagggta tcgaagacgg tacttggtat caaggtactt ccaaatacga aaaacgtggt
     5221 gtagctgcat tcgttcccga atggaatgct gaaaactgta ttcagtgtaa caagtgtgct
     5281 tacgtttgtc ctcacgcttc tatccgtccg ttcgtactcg atgctgaaga gcagaagggt
     5341 gctaagttcg agcaactgaa agctgtaggt aaagcattcg atggtatgac attccgtatt
     5401 caggtagacg ttctcgactg tctgggttgc ggtaactgtg ccgacatctg tccgggtaat
     5461 ccgaagaagg gtggtaaggc attgaccatg aaacaccttg aaagccagtt ggccgaagct
     5521 gataactgga cttactgcgc tgaaaacgtg aagagcaaac aacacctggt agacatcaag
     5581 gctaacgtga agaactctca gttcgcaact ccgttgtttg agttctcagg cgcttgctcc
     5641 ggttgtggtg aaactccgta cgtgaaactg atttctcagt tgttcggtga ccgtgaaatg
     5701 gttgctaacg ctacaggatg ttcttctatc tactccggtt cagttccttc tactccgtac
     5761 actatgaacg aaaagggtca cggtcctgca tgggctaact ccttgttcga agacttctgt
     5821 gaatttggtc tgggtatgga actggctaac gaaaagatgc gtgcccgtct ggtgaaagtg
     5881 atgaacgaag ctatcgcttc tgattgctgc ccggctgaat acaaagaagt atttgctgaa
     5941 tggatcaaca atatgctgga tgcagaaaag actaaggaac tggccgaaaa gatcattccg
     6001 atggtagaag ctgctaaaga taaatgcaac cactgcaagc aaatcgctga tctgcaacaa
     6061 tatcttgtta aacgcagcca atggatcatc ggtggtgacg gtgcttctta tgatatcggt
     6121 tacggtggtc ttgaccatgt aatcgcttcc ggtaaggacg ttaacatcct tgtattggat
     6181 actgaggttt actctaacac aggtggtcag tcttctaaag ctactccggt aggcgctatc
     6241 gctaagtttg ctgctgcagg taagcgtgta cgtaagaaag acctcggtct gatggctact
     6301 acttacggtt atgtatatgt tgctcagatt gctatgggtg ctgaccaggc tcagactctg
     6361 aaagctatcc gtgaagctga agcatatccg ggaccatcac tgatcatcgc ttacgctcca
     6421 tgtatcaacc acggtctgaa agccggtatg ggtaagagcc aggaagaaga agaaaaggct
     6481 gttaagtgcg gttactggca cttgtggcgt tacaaccctg ctttggaaga agaaggcaag
     6541 aatccgttcc aactggatag caaagaacct aactgggaag acttccaagg tttcttgaag
     6601 ggtgaagttc gttacgcttc tgtaatgaaa caatatcctg ctgaagctga agaactgttt
     6661 aaagctgctg aagaaaacgc taaatggcgt tacaacagct acaaacgtct tgccagagaa
     6721 aactggggag ctgatacagc tgaataataa gtagaaatac tttgtacata ataaaaggca
     6781 ggaatcctgg aaacagattc ctgccttttt tgtttatatc ttagaagtaa cgattacttc
     6841 tcacgaagat attcattaaa actctaaaga tatgatcgga tttgttattt ggattatcgg
     6901 tttgatactg actttcagag ctgccataga gatttggaat ataaatgcgg ctgtagagaa
     6961 aagacttata gcgattgtat taatcgttct taccagctgg ctgggactac ttttctacta
     7021 cttctatggt aaagaaagaa tggcgggatg gttgaagtag tgtttgcata tcaatctttc
     7081 tcaggaatcc aactgttcac cagttcctga tgttcttcca tccattgacg ggcagcctgt
     7141 ctttccgttg tctgcgcctc ttccagagca gtcattaagg agctgatttc cgcatctgtc
     7201 agacgaatgt tgcccaaaag ttcggcagca aaagggtctt tctcgctaaa acctttccat
     7261 gctatggtat gaatggattc cgtatttcca tatatcagct tcgggtcctg aagaactttc
     7321 agcttgaaac ggtcgaacat ccagtgaggc gtccatcccg tcacgacaat ccagtctttc
     7381 ttatcaatcg ctttctttag ggaagcagtc atggcaggtc cgctcgaagt catcagttta
     7441 taatccaatc catagtcttt gatggcctga tcggtagctt tcataatacc ggctccggca
     7501 tcaataccga caatctgacc ggagaaacgt tccttttccg cgttcagttc ttcgattgag
     7561 ttgatcgtaa cgtaatccgg aaccaccagc ccgatacggg caccatcata aatatccccg
     7621 ataacttcga gtttatcccc gtattgtttc atataatctt ccatagtgac aggcatccag
     7681 acatccataa atacgtctgc tttcttacgg gagatagagg taaatatagg tgcaaggtcg
     7741 gcattcagca actttacatc gtaccctgat cttcaaaaat cgctttggca aggtttgtca
     7801 ttgcaatacc ttccgaccag ttggcataag cgatacttat cttcttactc tttccgttgt
     7861 ctccgcagga acgaaggtta agagtatgcc ggcaataaac attgccgcaa tcatttttat
     7921 cttattcatt gattattcct ttctttggtg tgattcttat ttctttttac tttttctgtt
     7981 atctgccata ccctgagtga tgcggtccag cacgatcgcc aatatcacga ctgcgatacc
     8041 gccttcaaat ccgagtccga ttttcatttg ggtgatacct ttcagcacga tttctcccaa
     8101 tcctccggca gaaatcatgg cagcaatcac taccatcgaa agtgacatca tgatcgtctg
     8161 gttgattccc gtcagaatag taggcaacgc caaaggcaat tgcaccttat aaagaagctg
     8221 ccagggagta gctccaaaag agcgggaggc ttctactacg tttttaggaa cctgacgaat
     8281 gcccagaccg gtcagacgaa ccacaggagg cattgcaaag atgatggtgg caaaagcccc
     8341 cggcacagtt cccaatccga agaatagaac ggcaggaatc agatagacaa aggcaggcat
     8401 tgtctgcata aagtcgagga cagggcgcat tatcttgtta caacgatcac tgttggcagt
     8461 ccagattccc aacggaacgc ctaaaagcaa tgccagacaa gtggaagaaa gtaccaatgc
     8521 caatgtctgc atcgtttctt cccaaaagcc catgccgtaa ataagcaata aacccaagag
     8581 ggtaaatacg gctgtcccct tacccgactt aaaccaggcg agcgcagcca gcactgcgat
     8641 tgtgatataa aaaggtattc caaacagtac gtgctgaaaa ccgtctatga atcctccgat
     8701 ccccatgctg agagcatcaa aaaaggaagc aaaatgttct gtgagccaat taatggcagt
     8761 ctctatatat tgtccgatat ttatcataat tctattgcgt tttgaatgat ttcattaatt
     8821 tcttctttat cttttcccgt tacttcgatg atcaatgagg aaagtggcac tacgccttca
     8881 aactcccgat tctcatttac gacccagatt ggcgagttcg tttttgtcat caacggaaga
     8941 atatcttcca gcaccgtatc acccagcact gaatgaactt catgccttac tacggactcg
     9001 atggagcgga tttgctcttt tcgtagtttc agcaagtcat tcaaccgcac ctctcctact
     9061 aacagattat tggaatcgac taccggaaga acggtcagat tccgttcgcg catcttacgg
     9121 atcagcacct ccgggccttc tttcttcaaa cgtgccacta tgggtttatc taccataaca
     9181 gaggaagctg ttataatctt gcttcgatct acattctcca caaatcgttc tacataagcg
     9241 ttggcaggtt cggtcaggat ttcttccgat gtaccgattt gtacaatttc tccatccttc
     9301 atgatagcaa tccggtcacc caatttaatc gcttcactca ggtcgtgagt aataaagaca
     9361 atcgtttttt tcatcttcga ctgcaaagtc agcagttcat cctgcatctg cacacggatc
     9421 aaaggatcga gtgccgagaa ggcctcatcc atcaacagga cttcgggatt attggccaaa
     9481 gcccgcgcca gcccgacacg ctgctgcatc ccacccgaca gttcacttac catctgattc
     9541 tcgtagcctt tcagccccac cagttgcata ctttccatcg ctttctgctc ccgttctccc
     9601 ttttttactc cctgtagttc gagcccgaaa gctatattat gcaagacaga acggtgagga
     9661 agcagaccga agttctgaaa gaccatagcc agttctttcc ggcgaatctg caacagttcc
     9721 ttatccgaca ctttggctat gtctgttcca ttgataatca cttctccgga agtagggcgt
     9781 atcaaacggt tgatgcagcg gagtaaagtg gactttccac taccggacag ccccataatg
     9841 acgaatattt cgccttcatt aatggaaaga ttcgcatctt tcaccgcaac tgtacatccg
     9901 gtcgctttca atatttcact ttttgtttta ccttctttca acatcttcaa agccttctgc
     9961 ttctcattgc caaaaaccag atagagatct ttaatttcta ttttactcat acaataaaat
    10021 ggtttaggtt attaaaataa tatacacagc aagacaagaa caaacgataa caggaatctt
    10081 tctttatatc gtataaagtt ctgatttaaa tacgggacaa ataacaatga atcccgaaat
    10141 aattaataaa atgattattg acagactgag taattaaaaa aggaatagaa tttgataaga
    10201 taatcctttc aacgaatagc aaaaaatagc atttttatgt ataaaaacag cctgttccag
    10261 tatcttgctg gcacaaagat acaaaaaacg gattaaacat acaaattata ttcaaaatcc
    10321 ggggcataca gagggcttta tttgtaatga tatggaaagt ttccgggtaa tattccccta
    10381 tcactcagca aaatagaaca aaccggcaga taaatataaa ataagtttga atatttcact
    10441 taaacaccgt atatttggcg tcaataacta aactagattt atatgttcaa cagggctatt
    10501 acaattttcc tggggaagga taattgtcat tacacaacaa aagaaaaaca aacaggtact
    10561 gccacactag acgacaaaag ccaagtacag ttccttagta aaaagaaccc caaaatgccg
    10621 tttttctata gccggcggaa tctctacatg ataggtttcc tgctcgcttt tatagtgact
    10681 ctgctcgaat ttatacgagg acggcatcaa aactttatgg tcttctcgga cgctactcaa
    10741 ttcttctggc aaggcatcag cccatacaca actgaatttg tagaagctca cggacgctac
    10801 ttcctttatt ctccagtttt cacggtattg ttcgctccgt ttgcgtatct gcctgcatgg
    10861 ctgggacctt tcgcgtggaa tctattcaat tattcgctgt tctttatggc gatcttcacg
    10921 ctgccccaac aattcaccca gcagcagaaa tgccgtatgt tcctttttct gttactgatt
    10981 ttaggacaaa gtttactttc atttcagtat aacataacgg tagcctattt attcttattc
    11041 gcctatacgt tattggaaaa agaccgtgga tttctggctg ttctgttaat catgatttcg
    11101 ggatgtacca aagtatatgg aattttcgaa ctggcattgt tgctgtgcta tcctcacgta
    11161 tggcgtaact ttggctatgc cgttacaatg ggcattgtat tgcttgcatt accgttaatc
    11221 aaaatagctc ctgcagattt gctcccctat tatgaagaat ggtgccatag tcttgctgtt
    11281 catcagtcca ccggagctta tgattcattt ttctatgccc gccccattgc agtatggaca
    11341 ttgccacact tccgtgcact tcagatagga atgctcggct tgctgactct gctctttttg
    11401 gggaatttcc gcaaatggtc gtcttttgcc ttccgtgccc aggctttggg cattctcatg
    11461 ggctgggtag tattactgag tgactccgcc gagaagcata cctatattat cgcattggca
    11521 ggtttcatgc tctggtattg gagcagacca acacgtaccg caacagacaa gattctattt
    11581 tggtgctgtt ttgtgctgtt atgtatcgtt cctatcgaca tattcgtccc tgtacccatc
    11641 agagatttca ttaccaggac cttatggctt catgtatggg ttttctttat tgtatggata
    11701 cggatgatat ggcttacctt ccttgcatcc ttcattcatc cacgtgccac aaatgttctt
    11761 tcagattaac gcatccgtta gctttgaaag aaacttcttc tgccagcaag agttgttttt
    11821 gttccaccca accggggacc agccttccgg cggtatttac aactctatgg cagggaatgg
    11881 ataattcatc cggcacttct ttcaatgcac gtcccaccat acgcgagcat tggggtaccc
    11941 ccaacaacaa agcaatacct ccataggtag atacttttcc cacaggtatc tgggatacga
    12001 cttcgtacac ttccttccga aaggattcgg aaaagctctc tttatctact ttataatctt
    12061 tcatatatcc ctctttacga tatcaatgaa atcatccttt ccttttcagg aaatctgtcg
    12121 ggctctctcc aaactgctct ttatagcact tggcgaaata agaaggtgaa ctgaaaccga
    12181 cttcataacc aatctccgct acggtcatgt ccgaagaagc aagcaaagaa gctgccttct
    12241 tcaaacgggc gatacggagc aattcattcg gagagtagtt agtcaatgat ttaatcttgc
    12301 gataaagctg cacacggctt agtcccatgt ctttgcccaa gtcctccaca ttcaaaccgg
    12361 agtctcccat tttctcttca atcaatgact tgaatctttc tacaaaatcc ttgtccatat
    12421 cgcagacatc ttcttttgcc aatgtctgcc cgtcaccaaa gaactgtttc agacgacggt
    12481 gagaatcgat cagattgcgg acacgtgcca gcaacagctg tgaactgaac ggctttgaaa
    12541 tataagaatc cgcaccaccg tcatatccct gaatacgctg ttcgtccagt gaacacgctg
    12601 tcagcagaat aaccggaata tgacaggtct gtaactcact tttcagccgg cggcaacatt
    12661 caatgccatc aatgcccggc atcatcacat cagaaatgat caggtccgga acatacttca
    12721 tagccttacg gattccttcg gagccgtctg ccgcttcaat caccgtatag tctgtatgca
    12781 acagcgtatg aacatacgaa cggatatcct cattatcatc aataatcaat acggacgatt
    12841 tggaagagtc atatcctttt tccagttctt cctcttctgc caatagaaca tctgttgtac
    12901 gggaatccgc agaaacaagg gtggtatccg gttcggcagc aacagcctcg caagactgta
    12961 caggcagttc aacggtaaag accgtgccct gtttctcatc gctctctaca gagatcatac
    13021 caccgtgcat ttctacgaag gcttttacca atgccagtcc gattcccgaa ccggtatggt
    13081 gcatatcgat cttatagaaa cggtcgaata cattgcggat atgttcggca gaaatcatgg
    13141 aaccggtatt tgccaccgtg aaacgtatcc atcgcttgtc ctctttacta agggaagaca
    13201 gacggatggc tattttcccg ttttccggtg taaacttaaa ggcattggac aggagattga
    13261 aataaatacg ttccagcttc tccatgtctg ccagtgtatg ataatccgta tccggcatac
    13321 tatcaaaaga aaaatggata tgcttcttac gggctgccgc ctgaaaagac tcattccatc
    13381 cttcgaaaga agaaaggaca tccaccgtaa ccggagtata ttccatcttg ccgttttcat
    13441 atttacggaa atccagaatc tgattgacca gacgcagaag gatgttcaca ttccgctgaa
    13501 tcagcatgag catccggtgc tgatctccgc tcagtgtctt gtccgccaac aaatgttcta
    13561 ccggatcggc aaccaatgtc aacggagtac ggaagtcgtg agaaatattg gtgaagaata
    13621 ccagcttggc atgagtagct tcttccagtt gatgagaaag ttgtatcaat tggtcacgct
    13681 gttcttccag tttgtcacgt tgctcttcca attgttgctt ctgcttaaaa agttctttat
    13741 tcaagcgatt ctttgagcgg agtgatttat aaacgaccaa taataagccg gctaccaata
    13801 aaaggataat cagactgccg tataaaacga cctgttgtgt agctacctga gagagatagc
    13861 caccgatacg tccgttgagc gtttcaatct ttttgtcgag ttcggaaatg tgtgtggtct
    13921 gcaactgcat gacgtgtgcg ttggtacggt ccacaacagc ggtattcatc accgtttctt
    13981 tgggataggg tttcttctcc agaatatcca tagccagttg cagtacctta tcaccattgg
    14041 tcggatagat aaaggtggca tccagcacac tgtccagaac cagttccagt ccgtttccct
    14101 tacccggcaa ggcatctatg ccgacaaaaa tcatttcctt ctcccgccct gccatctttg
    14161 ctgcctgata ggcacccgga gcgatacggt cattatgggc atacacagca tcaatcttag
    14221 gatgcctccg aagcatacta tccatttcta tctctgccgg accacgttcc caagcagcat
    14281 ccgctttatc aatcagcttt atatccggga atttactgat ggcagccata aatccctgat
    14341 gccgttccat tgcaggagtc gaaccgctca atcctgtcag ttctactata tttcccttcc
    14401 ctttcagact ggaggcaata tagtttccta ccgaacgacc aatttcataa ttatcggctc
    14461 cgatataggc agtatattta tccgaaagaa tcttccggtc tacaagaata acggggatgc
    14521 ctttctgata agcttcttct acaatcggag tcataggagc agcttcgtta gcggaaataa
    14581 tcagcagatc gactccttcg tccataaaat aatggacatc ttccgcctgc ttactgttat
    14641 catcccctgc cgaacggatt tccaccgaaa caccattata aaacatcgct tcccgaagaa
    14701 tctcatcatt catcttatgt cgccatgaat catcgctgca ttgagccacc ccaatacgaa
    14761 aacggggtgt atcctgccgg caagccgtca tcccgattaa acaaaacagc accagcatcc
    14821 acttcagata tctcatcgtc ttcatccatc tcatcatttc gtagttcttt ctgtaatcca
    14881 attaagaaca aaaataagaa ataatactgt aaagttctct aacttcagct atttattatt
    14941 ctaaaaagaa ggaaagcagt cctctttcag accatcggaa agtattaaca aaagtataaa
    15001 gcgtaaaaca aacacttaat caatgttata aaacatagcg ttttacttgg ataatttgca
    15061 gatttcacag aagtccgtat ctttgcactg tgtttttcat agtattagat ttaaggttaa
    15121 caaaggttgg agcaaggcgt tgctcctttt tttatgccct gacctttcat ctaccggtta
    15181 gttttcatcc cattcctttt ccagtttacc atcaatagtg tagcgtttcc atcgtcctac
    15241 acggcgacca ttcttatatt ccccacattc acgaagctgg tcattcttta cataacgagc
    15301 ttcgaacggt ccgttctgcc ttccgttcac ataggtagaa gtttcccaat aatcaaagcg
    15361 gttgctcact atcagccgtc gttccttgcc atgcaatctg ccggcctgat aggtagcttc
    15421 atatctcaat tcaccatttt ccagattata ttcacggtat aaaccgtctt tacgatcgtt
    15481 cttcatataa tattctttct gccttacccc acttccgttg gcaaatgaga catggagtcc
    15541 atcttctttt ccatccagat aggtttcaat catcagcgta tctccgcttt cagcaaaagt
    15601 agtccaccga ccattcttct ttccattctt ataactaccc agtatacgtg gcgagccaaa
    15661 cgtaaacacg gacgaatatt caccgtcctg caaaccttct tcattgaaat aaacggtctc
    15721 atacaaatca tatgtacctt tcagaaaagt atactgtttg cctacctgct tcccgtcctt
    15781 gtaattatgc tctttccgca aagtaccgtc agattcgtac gacagttgct tcccgtgctc
    15841 tttccccatc cggaagtttc tttcactttc cacttttccg gtagtaaagt aacttttgct
    15901 cgtaccatcc agcttacctt ccttatagga cttttcttct ttcagcttac cgtcaaactt
    15961 ggagttaatc ttgaagaggc catccttccg cccttcttta taacttcctt ccgttattaa
    16021 tatattgtcc acatattctt tgtatccgcc atcataaaaa ccatctttaa aagatgccag
    16081 cacataggcg gaatgataac catctatgat gcgatgttcg ccattcaatg ctttttccgt
    16141 tttcagttcc tgaaacaaca gtctgccatc gcctacatta acaacagata cctgatcgat
    16201 cttatattcc ttttgcgcaa acaaaggaag agcaagatat aaaaacaaaa atacgttcca
    16261 gctttttgat ctgaggaagt tcgaaatgtg tttcataaag tagttttctc tttttgattt
    16321 attatttaaa aacctgccgc aaagataggc aatcggctta taaaacaagg caaggaagag
    16381 ggggacaatt agaaaaaaga acatctgtta ttatcattct aataattaac agattaagta
    16441 gtaaatcaaa acacagggaa gggggacatt tactgaaata agaaacagaa aagaagatgt
    16501 gccaaaagca actaaattcc cctccttcag gaaggaggag agtttagttg cttttgacac
    16561 atttacattt gcagtattaa atatcacaac aaaatataag tgtatatttg aaaagtagag
    16621 ttgcagtgaa ctaactttga cactagtctt aaatgactat aggctga
//
