LOCUS       c00001_gnlPro..        14847 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CCBCIBCO_1.
ACCESSION   c00001_gnlPro..
VERSION     c00001_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 22:40:27
            Original ID  :: gnl|Prokka|CCBCIBCO_1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14847
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14847
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1407:4847]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1408..4847
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14847
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14847
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(195..1148)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKALDYKIGNKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFESD"
     CDS             1408..2082
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="SucD_FumR (E-value: 1.7e-66, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             2121..4064
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.1e-59, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.6e-37,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             4092..4847
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="Fer2_3 (E-value: 1.7e-25, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 4.9e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.2e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             5035..5193
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSVDSDT"
     CDS             complement(5166..6197)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEAKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREARHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     TDC"
     CDS             6578..7837
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="Peptidase_U32 (E-value: 2.3e-68, bitscore:
                     223.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNEKDFEIMAPVGSYESLMAAIQGGADSIYFGIEGLNMRSRSSNN
                     FTTDDLRKIVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAADVAAM
                     NYANSIGQEVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQQITG
                     PKGELIRIEMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIEL
                     DIENQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNG
                     TFDEKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDK
                     IGVAEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEK
                     IRPSDRLYKMEKVQLEKVFE"
     CDS             7837..8244
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="HBT (E-value: 2.2e-08, bitscore: 28.2,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 4.7e-09, bitscore: 30.6,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLRSGDSYISCLNVYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             8241..9338
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDTPILFYF
                     KGNTDLDATRIISIVGTRNATKYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRVGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAAATPVQMELFSASEQNPVLAIMRTRNEIHINELASVLEMPVHQ
                     LSMLLFELEINGKVKALPGNLYKLS"
     CDS             complement(9589..10485)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MKMLSFILVLLLGGGMPAGNLLASDKEQNSHYITVKNSRDLQAYF
                     RYAPDRPIVISGHRGGMLDGYPENCIESFEKTLSYMESFFEIDPRLTKDGIIVLMHDET
                     IDRTTTGKGKVSDYTYAELQQFNLVDRNGNVTTFKIPTLKECLEWSKGKTILNLDIKDV
                     PLEVMADFIETEKPVNVIYTVHNAGQARYYLDRKPDAMFSCWCKNREEFDNYEKAGIPW
                     KQVMAYVGPKMKPEQQPLYDALHRNGVMCMISVAPTHDRAKTETEKTAGYQSEISTRPD
                     VIETDYPYLFQGLDLTK"
     CDS             11089..11451
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MERLTRQEEDVMRWIWQIEPCFIKDILAKYEEPKPPYTTLASIVK
                     NLERKKYVKAKRYGNTYEYRPLIPQEEYKRTFMGSVVNNYFENSYKEMVSFFAKEQKIS
                     TDELKEIIDMIEKGRE"
     CDS             11472..13208
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MTPEFAYFLKVNVAFILLYAFYRLFFYKDTFFKLRRTILLAFFGV
                     SLLYPLMNIQDWIREQGPIVEVIQMYSAILPETTITPGNVPQTNWHDLLLSGISYLYWS
                     GVIALSFRFLVQLSSILLLARRSEVTLIRNVRVHLLNKPAGPFSFFRLVFLHPDSHSEK
                     EIDEILVHECTHVSQWHSIDVIICELVCIICWVNPFVWLLKREVRHNLEYLADDTVLES
                     GYDSRSYQYHLLGLAHTNRSVTSLSNNFNMLHLKNRISMMNKKRSRSIGRTKYLIFIPI
                     VGALLILSNVDALARITDELTESTFADVLLPEAILPFPFVGDASPAEKREEYVLSEEGI
                     EAARRARNQVFTVVEVMPEFPGGQGALLKFLATNVRYPESAVKNGIEGRVSCSFVVGKD
                     GAISEAEVIRGVSPELNEEALRVINSMPVWSPGKQRGKAVNVKYTVPVTFRLSGGKKKT
                     SSRIVQRQIKEVDTSGRVFTVVQQMPEFPGGQASLLKYLATRIKYPAIAQENGIQGRVS
                     CSFVVDTDGSLKNIEVIRGIDPSLDREAVRVIREMPKWNPGVQNNMAVAVKYTVPVTFR
                     LQ"
     CDS             13242..14795
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MKCKFSLLLFLCVLSLWGQAQSLNLQELVNKKQFQEVVARADSLT
                     PADSADYATMSAIGQAYEGLLRYKEAYQCFSHCLKMDTNNVDALNAVARNAINFGRIAE
                     AKQCYRKVLGTDSMNFYANYQLARLYYQLGDYGRATEHYHILASIEGENPSILTGLADC
                     HIKRGTGPNTMIALSLYARALELNPENVRVASSLINTLLRMGDGQGALQVCDTALFYNP
                     DNSQIRQSKGMALYMTKDYKQADSVYTGLLADGDSSFLNLKYAGAARYMSGHALDGVEL
                     LEKAYEIDSTDVETVMLYGASLGKTYDRKRAYELFDLAETNMQPKKFLVNMLTTFRGDA
                     LERDGRWPEAEKLYYAAWKEDPTQLHFLYKISTQYWDVDPGLFQQEEKLQKTIFSRYTY
                     LTAYMKTDKSQKYLYNYRPFLEAVCEDAFFRNADEVTMLAPDGKKTKLAVADLRALVAQ
                     LPQMPEDERLRREKMQEHIKKAREKEKELRKSGAKLDTLALSKEEKEKARKMLKDADLE
                     "
ORIGIN
        1 ataagagcgt aagatccggg tgtcgggggg cgggcacatg gggggtgttg ggcaagtttt
       61 attacgtgtt tttcattgat ttgtagctgt atttacataa aagagccttg tctttgatga
      121 tataggagaa caagcccttt ttccttttct tgtttacctt gccctgcaaa ttgtcagttt
      181 gttttagtag aaattcaatc actttcgaaa tcggacagca cttctgccgt agtagcgttg
      241 atgttcttgt ccaatacata aatgcggtaa gacaggctca gttctttacc gggttccaag
      301 gtgaatgcct tctgcttggt cggtgagaaa ttccacatga cgtcaccggc aggcttgttg
      361 acagttttgt cccatacgcg taaaggctca ggatagttca ggttggaagg ggaggcaacg
      421 attaggatac aggccttttc gtttccggct ttcccttggt aatagcacca acgggctctc
      481 gaaccgtcag cttcgtcgcg ggaaaggcct tccgaggtga gcatttcggc tgtctgatcg
      541 ttccagtctt cgcgcgtacg gatgcatatg ccgccataac ggtaagcttc catggtgatc
      601 gggctggggc tggcgaggcg gatagtggta tgatagtcga tgtaataacc tggtaaggat
      661 gttgtcccga tgttgatctc caggcgttcg ttcattgcta ctttttctgc gggagaatcg
      721 gggtagacca catggtccag tgtcgcaaca aaaccgttgt cggatacgtg ctcgaagttg
      781 cggaagcgaa ctgttccttg ttttttgtgg agattccaga agtcgatctc gtttccttcg
      841 aacgtggttt tcgtccaggc ataccacaaa ccgaaatgat ggtaatggtc ggcgggagaa
      901 caattggtca tcacttcgcc tcccaatgtc ttcaaaggat ggatgaaacc gctgcgttta
      961 tagaccgagt caacgccagg ggctgggtaa accgtggtat agttgtaaga gaacaacagt
     1021 ttatttccta tcttatagtc caaggctttc cccgtgtcga cgacggaaca ggatgtttcg
     1081 gaaggctgac aagagcctaa gaacagagaa atcaaaaaaa caccaataga aaaaatagca
     1141 gttttcataa tatgacaatt aaataataat cagttatccg gcaagacctt gcctgtatcg
     1201 gctacaaaaa aacgaaattt tttcgtttcg tacaatccgt ttgtgatatc tgatgaaaat
     1261 aaaaccagcc agcaagcagc gttctaattg atgaaatatt tctttaatcg tttgcgtgat
     1321 atggggattt agcatacctt tgcacgataa taaccataga ttggaagaaa tttctaaata
     1381 caattaaata acttaaatta ttatcttatg tggttactta attcttctat cgggaagaag
     1441 ctgataatga gtatatcagg tctttttctc attctgttct tggtgttcca cttatgtatg
     1501 aacattgcgg cagtattttc tggtgaagcg tataacgtga tttgcggttt gctgggttct
     1561 aactggtatg ctttgctcgg tacattggtg ttggctgcag gtgtagtcgt gcacttcgtg
     1621 tatgctatta tcttgactct gcagaatcgt aaggctcgcg gtaacgaccg ttatgccatc
     1681 aacgctcgtc cgaaaggtgt tgaatgggct tctcagaaca tgtttgtttt gggtgtgatc
     1741 gttatcctgt tcatggttct gcactttact cagttctggt acaacatgat gtttgccgaa
     1801 ctggcaggta ttcatggtga cattcatccg caggatggtg cagcgtttat caatttctac
     1861 ttccagggca atgtcgtgaa tacggtgttg tatctgatct ggttcgttgc tctgtggttt
     1921 cacctgactc acggtttctg gtctgcgatt cacacaattg gctggaacaa taccgtttgg
     1981 ttaagccgtt gggaatgtat ctctaaatgg gttgccacta ttatttgtgg cttattcgct
     2041 gttatcacag ttatcttcta cctgaacggt gtaggtgctt aatttcggat attatttttt
     2101 caatttgaaa ataaaacatt atgactcaaa tagattctaa aattcctcaa ggcccgttgg
     2161 ctgagaagtg gacaaattat aaaaatcacc agaaattggt gaatcccgca aacaaacgtc
     2221 gtttggacat aattgtagta ggtactggtc tggcgggtgc ttctgctgct gcctctctgg
     2281 ctgaaatggg attcaatgta ttgaatttct gtattcagga ctctccccgt cgtgcacact
     2341 ctatcgctgc acagggcggt atcaatgcgg caaagaatta tcagaatgat ggtgactcgg
     2401 tttatcgtct gttctacgat acaatcaaag gtggtgacta ccgtgcccgc gaagcaaacg
     2461 tctatcgtct ggctgaagtg tcaaactcta ttatcgacca gtgtgtggca cagggtgtac
     2521 cattcgctcg cgaatatggt ggtctgttgg ataaccgctc attcggtggt gctcaggtat
     2581 cccgtacgtt ctatgcccgt ggtcagaccg gacagcagct gctgttgggt gcttactctg
     2641 cattgagccg tcagattggt ttgggaaagg tgaagatgta cacacgccat gaaatgctgg
     2701 atgttgtgaa ggttgacgga cgtgctcgcg gtattattgc ccgtaatttg attaccggta
     2761 agatcgaacg ttttgccgct cacgcagtcg ttgttgcgac aggtggttat gtaaatacat
     2821 tcttcttgtc tactaacgcg atggcgtcta acggttctgc tgcatggcag tgctacaaga
     2881 aaggggctta ctttgctaac ccttgtatgg tgcagatcca cccgacttgt gtgccggtga
     2941 aaggtgactt ccagtctaag ctgactttga tgtcagaatc actgcgtaac gatggtcgca
     3001 tctgggttcc gaagaaactg gaagatgcga aggcattgca ggccggaaca aaaaaaggta
     3061 aggatattcc tgaagcagat cgcgactact atctggaacg tcgttatccg gcattcggta
     3121 acttggttcc tcgtgatgtg gcttcacgtg ccgctaaaga acgttgtgat gccggtttcg
     3181 gtgtaaatag cacgggcttg gctgtattcc tggatttctc cgacgctatc aaccgtctgg
     3241 gtaaggaagt agttaaacag aaatatggta acctgttcga tatgtacgaa gagatcacga
     3301 acgatgatcc gtacgaaact ccgatgatga tttatcctgc attgcactac tcaatgggtg
     3361 gtttgtgggt agactatgaa ttgatgactt ctattccggg gctgttcgca atcggtgaag
     3421 caaacttctc tgaccacggc gctaaccgtc tgggtgcttc tgctttgatg cagggattgg
     3481 ctgatggtta ctttgtattg ccttacacga tccagaacta tctgtctgac cagatccagg
     3541 ttccgcgctt cagcactgac ctgcctgaat ttgtggaagc agaaaaggct attaacgctc
     3601 gtatcgcgaa gttgatgaac gtgaagggta aagaaactgt cgattctatc catcgtaagc
     3661 tgggacatat catgtgggaa cacgtcggta tggcacgcga cgcggaaggc ttgaaagaag
     3721 ctatccaaat gttgaaagac ctgaagaagg aattctggag caatgtattc attccgggtg
     3781 aggccaatag cttgaacgtg gaattggaca aggcattgcg tttggctgac tttatcgaaa
     3841 tcggtgcatt gatggcacac gatgcgttag accgtgcaga atcttgtggt ggccacttcc
     3901 gtacggaaca tcagaccgaa gaaggcgaag ctatgcgtca tgacgataag ttcatgtacg
     3961 tctcttgttg ggaataccag ggtgaagaca aagacccggt tatgctgaag gaagatttga
     4021 actatcagtt cgttgttcct caaacacgta actacaagaa gtaataatca tcaatcacaa
     4081 aaattagaat catggataaa gatataaagg taacacttaa agtttggcgt cagaaaggtc
     4141 cgaaagataa aggacagttt gagacttacc aaatcgacaa aatcaatcag agtgtttctt
     4201 tcttggaaat gttagacatt ttgaatgaac gtttggttag cgaaggcaaa gaacctatcg
     4261 tattcgacca cgactgccgt gaaggtatct gcggtatgtg ttcattgtat gtaaacggac
     4321 atccgcacgg accggcaaca ggtgcaacaa cctgtcagct ctatatgcgt cgttttaatg
     4381 atggtgagac gattacgatc gagccgtggc gttctgccgg tttcccggta atccgcgact
     4441 tgatggtaga ccgttatgct tatgataaga ttatccaggc aggtggtttc gtttctgtaa
     4501 acacaggtgg ggttcctgat gctaatgcaa ttcctatttc taaggctgat gcggatttgg
     4561 ctatggatgc tgctgcttgt atcggctgcg gtgcttgtgc tgctgcttgt aagaacggtt
     4621 cagctatgct gttcgtctct gcaaaggtta gccagctggc tcttttgcct cagggtaagg
     4681 tggaagctgc tcgccgtgca aaagcaatgg ttgctaagat ggatgaactg ggctttggta
     4741 actgtacgaa cactcgcgct tgcgaaatgg aatgtccgaa gaacatctcc gttagcaaca
     4801 tcgctcgctt gaaccgcgag ttcatctctg ctaagttaca agactaatac attatatatg
     4861 tatatggaaa agcccgtcgc caatggcaac gggctttctt tatgttcgtt caaacccaca
     4921 aaaaagcgca ctccctataa taaaagtgga tgcggctttt ttgttgcttt ccagtgaaac
     4981 agtctctcga ttccctctct gcaaagactt tgttaacctt agatctaaaa tactatgaaa
     5041 aaaactcact gcaaatataa agtatattta ctgaatacgc aagagtttgt aattacattt
     5101 tattgcaaat ttgctacttt ttgttttaaa attgacactg tgtgcggatt cacactgtta
     5161 ttatatcaac aatcggtcga ttctgacact tgagagtcgc tttgaaatcc gtatcctgta
     5221 tgaaatttgt cggggataga atccagaatg tcgaataatg cttccactgt ttccgcacgt
     5281 agcatggcga cgcgtgtctg cttgaagtct gcaatacctt taaacagcgg agttgcagcc
     5341 aaatggcggc gaatgtggag aattccccgg cgctcatcca aacgttccac gctttgttcc
     5401 acctgctttt tcagtatgtc cagataccat gagaaagatt cggcaggcaa tgtctcgccc
     5461 gtatccaggt aatgcctcgc ttctctgaaa atccaggggc ggcctatgct gccccggcca
     5521 atcataacgg catccacgcc atattgttcg aaacgttgtt tgcagatttc ggcggaagta
     5581 acatcgccat tgccgatgat gggaatttgt atgcggggat tgttttttgc ttcgccgatt
     5641 agtgtccagt ctgcctctcc tgtgtacatt tgtgcccggg tacgtccgtg gatggaaagg
     5701 gctgcgatac cgcaatcctg tagctgttcg gccaagtcta cgatgatccg gttgtcggca
     5761 tcccagccca agcgggtctt tacggtgaca gggatgttca ccgctttgac gacttcacgg
     5821 gtgatgtcca gcatcagtgg aatattgcgc agcatgccgg cgcctgctcc tttgcctgcc
     5881 actcgtttga caggacaacc gaaattgata tcgagaatgt ccggatgagc agcttcgcaa
     5941 atttgcgcgg cttcgaccat tgtcggaaca tcacggccat atatctgtat ggcgaccgga
     6001 cgttcttcat ccgccacgtt cagcttttgc tgtgttttat ttacactgcg gatcagggcg
     6061 tctgctgaaa cgaattcggt atacaccata tccgcaccaa aacgtttaca catcaaccgg
     6121 aaagaaatat ctgttacatc ttccatagga gccaggaaga cggggcgttc gcctaaatct
     6181 attgtaccta ttttcatatt tatatcatca ataacgggta caaaggtact gatttcctgc
     6241 taaaaacagg gataaaagga tatctactaa aaaatgtagt aattgatcaa taaaaagtac
     6301 aaatgtcata ctgtcaatga tatagataaa atgataagct gaaatcatga tagttgcatg
     6361 atagtagcat gatagttaaa aatagaaact atcatgtctt aaggtattga ataacagatt
     6421 ctaaaggaca acaatgacag tatgatggtt gttttgcaaa tctttataga aaatggtatt
     6481 tgatcacgat tttgatgctc tgagaaacgg atacccatgc aattcttctc ggatattatt
     6541 cctacctttg cgaacgaacc agtaaatgta taagaacttg aacgagaaag attttgaaat
     6601 aatggcgcct gtcggttcgt acgaatcgct gatggcggct atccaagggg gagccgattc
     6661 tatctatttc ggtatcgaag gattgaatat gcgttcgcgc tcttccaata actttacgac
     6721 agacgatttg cgcaagatcg ttgcgctttg tcgtgagcac ggtattaaga gctatttgac
     6781 cgtcaatacg gttatttatg gggaagacct gcctctgatg cgcgagatta tcgatgcagc
     6841 gaaagaggcg gaagtttcag cgatcattgc ggccgatgtg gcagctatga actatgccaa
     6901 cagcatcgga caggaggtgc atctttccac acagctcaac atttccaatg cggaagcact
     6961 gaaattctat gcccgttttg ccgatgttgt cgtcttggcg cgtgagctga atttgaaaca
     7021 ggtgcatgaa atctatcggc agatcgtcga ccagcagatt acgggaccga aaggagaact
     7081 gatccgtatc gaaatgtttg cccacggagc tctctgtatg gccgtttccg gtaaatgtta
     7141 cctgagcctg cacgaaatga acgcttccgc caaccgggga gcttgcatgc agatttgtcg
     7201 gcgtgcttat tcggtaaaag ataaagacag caatatcgaa ctggatatcg aaaaccagta
     7261 tattatgtcg cctaaagacc ttaagacaat tcatttcatg aataagatga tggatgcagg
     7321 tgtacgggta ttcaagatcg aaggacgtgc ccgcggtccc gaatatgtcc gtctggtgac
     7381 cgaatgctat aaggaagctg tgcgtgccta ttgcaatggc acgttcgatg aaaagaaagt
     7441 tgccgcttgg gacgaacgcc tgcgcagtgt gttcaaccga ggattctggg acggctatta
     7501 tttggggcaa cggttgggtg agtggagtag caaatatggc tccggcgcga ctaagaagaa
     7561 agtgtatgtt gccaaaggaa tcaaatattt cgacaagatc ggcgtggcgg agttcgaaat
     7621 ggaatccggt aacctgaaag tgggtgatga gatcctgatt accggaccga caacgggtgc
     7681 ggttatgcag acgatagaag aaatccgtgt ggacttgaag ccggtggacg agaccgttaa
     7741 aggtgaacgg ttctctctca aggtgaacga gaagattcgg ccgtctgacc gattgtataa
     7801 aatggaaaag gtgcaacttg aaaaggtatt tgaataatga aagagtatat ttttaaactg
     7861 acagacaagg tccgtgacta cgaatgcgac ctgcaaggag tggtcaacaa ctccaattat
     7921 cagcattata tggaacatac tcgacatgaa ttcttggagt cgcttggtga gaacttcggg
     7981 aagatgcacg aaaaaggggt tgacggattt gtatcgcggg tagaaatcca gtataagacc
     8041 tcgctcagga gcggcgacag ctatatctct tgcctcaatg tctataaaaa aggagtcaag
     8101 ctcgtattcg agcaggatat atatagggct tctgacaatg cattggcgac gaaaggaatc
     8161 gttgagtcgg ttatcgttga gaacggaaag ttgacacgcg gtgaatattt cgacgaaatg
     8221 ctaaaaagaa tagaacatac atgactgaca aacggattta ccaaatcggc cttactatga
     8281 taaacggtgt gggagatatc ctggcgcgcc atctcctgca ggctttggga gaagcagagg
     8341 ctgtgtttac tgaaaagcaa cagttgttag gaaggatccc tggtatcggc agcaatattg
     8401 ctgccgaaat caaacgcccg gaaatcttgc aacgggcgga aaaagagttg gcttttattg
     8461 agaaaaacaa tatttcctgt tattatctga ctgatacaga ttatccggtg cgcttgagag
     8521 aatgtccgga tacccctata cttttctatt ttaagggaaa tactgacctt gatgcaaccc
     8581 gtatcatcag tattgtgggt actcgcaacg cgaccaaata tggccgggag cttaccgaat
     8641 cccttataaa agacttggca aaagtgatcc cggacttgtt ggtcgtgagt ggattggctt
     8701 acggcatcga tatctgtgcc caccggaacg ccttgtacaa ccgacttccg actgttgctg
     8761 tgctggcgca tggcttggat cgtatctatc cttcctgcca tcggaatacg gctgtcgaaa
     8821 tgctggaatc gggcggtctg ttgaccgatt ttcccagcgg cacagaacca gaccgtccaa
     8881 atttcctccg gcggaaccgg attgtcgccg gaatctcgga ttgtacgatc gtggttgaat
     8941 cggctgaaaa aggaggctct ttggtaactg ccgatattgc attctcttat ggccgagatg
     9001 tctatagctt tccagggcgc gtcggtgaca gccattctaa aggatgcaac aatttgatcc
     9061 gacaaaacaa agccggcctg atcacttctg cggacgatct gctctccgct ctttgttggg
     9121 atatccaagc tgcggctact cccgttcaaa tggagctgtt ttccgcctcg gaacaaaatc
     9181 cggttttagc cattatgcga acgcggaatg agatccatat caacgagctt gcctcagtgt
     9241 tggagatgcc ggtacatcaa ctctctatgc tattgttcga actggaaata aacgggaagg
     9301 taaaagcgtt gccgggaaat ctctataagc tgtcctgacc ggctttttcg tatacgattt
     9361 gtatgtggga gaagaaacgg aacctctata aacaattaaa ggctgtctca cgacaacccc
     9421 taaccaactt tgttaacctt aaatctaata ctattatgaa aaaaccacat tgcaaagata
     9481 cactcgtcaa gagcgtttgt caagcatttt gtcgctaata cttgttaatc agatgagcat
     9541 aaatagcaaa aagattttaa tcggctataa agagtccttt aaactgcgct attttgttaa
     9601 atcgagtcct tgaaacaggt acggatagtc cgtttcgatc acgtcgggac gagtgctgat
     9661 ctctgactgg taaccagcgg ttttctctgt ttccgttttc gcgcgatcat gtgtcggagc
     9721 aacggaaatc atgcacatga ctccgttacg gtgcagagcg tcatacagtg gttgctgttc
     9781 aggcttcatc ttcggaccga cataagccat tacctgtttc caggggatgc cggctttttc
     9841 ataattatcg aattcttccc gattcttaca ccagcaagaa aacatcgcat ccggtttccg
     9901 gtcaagataa tagcgggctt gaccggcgtt atgtaccgtg tatattacgt taacaggctt
     9961 ttctgtttct ataaaatcag ccataacttc taaaggtaca tccttgatat ccaaattcag
    10021 gattgttttg cctttgctcc attccaggca ttcttttaaa gttggaattt tgaaggttgt
    10081 cacgttgccg tttcggtcca ccagattgaa ttgttgcagt tctgcataag tgtaatctga
    10141 aacctttcct tttccagtag ttgtccggtc gatggtttcg tcgtgcatca atacgattat
    10201 cccatctttt gtcaaacgtg ggtctatctc gaaaaacgat tccatatagg acagggtctt
    10261 ttcgaatgat tcgatgcagt tctccggata gccgtccagc attccaccac gatgtccgct
    10321 gattacaatc gggcgatcgg gagcataccg gaaataggct tgcaggtccc gactgttctt
    10381 cacagtaatg taatgagaat tttgttcttt gtctgaagcc aaaagattcc cggcaggcat
    10441 acccccccct aaaaggagta ccaaaataaa agatagcatt ttcatgatat tgtatttata
    10501 tagattcctt atcaattatg cggcttaaaa gtaagacttt tttatcagtg gcgtactata
    10561 aaaagcgcta caaaaatatg aaaatatgac cggaaacaat atatgcaaag gaagaggcag
    10621 gtatataaaa aattaaggat tgtcatctcg acaaccccta accaactttg ttaaccttaa
    10681 atctaatact attatgaaaa aaccacaata caaaagtaca ctaaccaagc ttgtttgtca
    10741 agcctttcat ggataatata tgttaagttt taatagctat tttgtcaaaa aatgttggtt
    10801 atttctaaac tatacagatt atatgtaaaa actgctaatt caaatacttt ttatcgtcga
    10861 aaaaagtgaa atcccatgct taaaaaatgt ccccttggag tatataaaat cattaattaa
    10921 tataggggga tgtttttggt gtggctgctt atagataaat tcctttttgg cgtatgcagc
    10981 gaatagatga tggattatta attattaata caaattaacg cattattcct tgcgtattta
    11041 cgatgtattc gtagatttgc gatgcgatcg taaaaataat atagaaacat ggaaagatta
    11101 acaagacagg aagaggatgt aatgcgctgg atctggcaga tcgagccgtg ttttatcaaa
    11161 gacatcctgg cgaagtatga agagcctaag cctccttata cgacactcgc ttctattgtg
    11221 aagaatctgg aacgtaagaa atacgtgaaa gcgaaacgtt acggaaatac ttacgaatac
    11281 aggccgctga tcccacagga ggaatataaa cggacgttta tgggaagtgt ggtgaacaac
    11341 tatttcgaga attcttacaa ggaaatggtc tccttttttg ctaaggaaca gaagatatcg
    11401 accgatgagt tgaaagagat tatcgatatg attgaaaaag gacgagaata aactgttaaa
    11461 tacataatgc catgacaccg gaatttgcct acttcttgaa ggtaaatgta gcttttatac
    11521 tcctttatgc cttctaccgg ctgttctttt ataaggacac cttctttaaa ctacgccgta
    11581 ccattttgtt ggcatttttc ggggtgtcat tgctttatcc gctgatgaat attcaggatt
    11641 ggatccggga gcaggggccg atagtggaag tcatacaaat gtattcagcc attttgcctg
    11701 aaacgacaat aacccccggc aatgttcccc aaacaaattg gcatgatttg ttactttccg
    11761 gtatttctta tctttattgg agcggtgtaa ttgccttatc gttccgtttt ttagtacagt
    11821 tgagcagcat cttgttactg gcacggcggt cggaagtgac tttgatccgt aacgtacgtg
    11881 tacatctgtt gaataaaccg gccggtcctt tttctttttt ccggctggta tttctgcatc
    11941 ccgacagcca ttccgagaaa gagatcgatg agattttggt acacgagtgt acgcatgtca
    12001 gccagtggca ttcgattgac gtgattattt gcgaattggt ttgtatcatc tgttgggtga
    12061 atccgtttgt ctggctgttg aaaagagagg tacgtcataa tctggaatat ttggcggatg
    12121 atacggtact tgaatcgggc tatgacagtc gtagctacca atatcacctt ttggggttgg
    12181 cacataccaa tagatcggtg acctctttat ctaataactt taatatgctg catctgaaaa
    12241 atcggatcag catgatgaat aagaaacgtt cccggagcat agggaggacg aaatacctga
    12301 tttttatacc gattgtgggc gccttgctga ttttgagcaa tgtcgatgca ttggcccgga
    12361 tcacggacga actgacggaa agcacgtttg ccgatgtctt actaccggag gctatcttgc
    12421 cgttcccttt tgtcggtgat gcttctcctg ctgaaaaacg tgaggagtat gtgctatcgg
    12481 aggaaggaat tgaggctgcc agacgtgccc gtaaccaggt gtttaccgtt gtggaggtaa
    12541 tgccggaatt ccctggcgga cagggtgctc tgctgaaatt cctggcgacg aatgtcagat
    12601 acccggaatc ggccgttaaa aatggtatag agggacgggt tagctgttct ttcgttgttg
    12661 gaaaagacgg agctatctcg gaggcagaag tgattcgtgg ggtaagtccg gaactgaatg
    12721 aggaggcttt gcgtgtgata aactccatgc cggtatggtc gccgggaaaa cagcggggca
    12781 aagcggttaa tgtcaaatat acggtaccgg taactttccg gctttccggt ggaaagaaaa
    12841 aaacatcctc tcgtatcgtg cagaggcaga ttaaagaagt cgatacgtcc ggtcgtgtct
    12901 ttacggtagt gcaacagatg ccggaatttc cgggtggaca ggcttcgttg ttgaaatatc
    12961 tggcaacacg cataaaatat ccggctattg ctcaggagaa tggaatacaa ggacgtgtct
    13021 cttgctcttt cgttgtcgac acggatggaa gtttgaaaaa tattgaagtg atccgtggaa
    13081 tcgatccttc gctggacagg gaggctgtcc gggtgatccg ggaaatgccg aaatggaatc
    13141 ctggcgtaca aaacaatatg gctgtagccg taaaatatac ggttccggtt actttccgtt
    13201 tgcagtaatt gaccagaatc ggtcattaat acgataccat tatgaaatgt aagttttctc
    13261 tattactgtt tctttgcgta ctgtcccttt ggggacaggc gcagagtctt aatcttcagg
    13321 aattggtcaa taaaaaacaa tttcaggaag ttgtagcacg tgcggatagt cttactcctg
    13381 ccgattcagc cgattatgct acaatgtcgg caatcgggca ggcgtatgag ggactgttgc
    13441 gctataagga ggcctatcag tgcttttctc attgcttgaa gatggatacg aacaatgtgg
    13501 atgcattgaa tgccgttgcc aggaatgcga tcaatttcgg aaggatagcg gaagctaaac
    13561 aatgttatcg taaagtattg ggaaccgaca gcatgaattt ttatgccaac tatcagttgg
    13621 cgcgtctcta ttatcagttg ggagattatg gtcgagcgac ggaacactat catatacttg
    13681 cttccatcga aggtgaaaat ccttctatcc tgactgggct ggctgattgc catattaaaa
    13741 gagggaccgg tcctaatacg atgatcgctc tttctttgta tgcccgtgct ttggagctga
    13801 acccggaaaa tgtgcgtgtg gcatcttctc tgataaatac gttattgcgg atgggggacg
    13861 gacagggagc tttgcaggtg tgcgataccg ccttgttcta taatccggat aacagccaga
    13921 tacggcagag taaagggatg gctctctata tgacgaaaga ttataagcag gctgattcag
    13981 tctataccgg tctattggcc gatggcgatt cttctttttt gaatcttaaa tatgcggggg
    14041 cggcccgcta tatgtccggt catgcacttg atggggtcga gctgctggag aaggcctatg
    14101 aaatagattc gacggatgtg gaaacagtca tgttgtatgg cgcttccctg ggaaaaacat
    14161 acgaccgtaa acgggcttat gagcttttcg atctggcgga aacgaatatg cagccgaaaa
    14221 agttcctagt taatatgttg acgaccttcc gaggtgatgc cttggaaagg gacggccgtt
    14281 ggcccgaagc ggaaaagctg tattatgccg catggaagga agacccaacc cagttacact
    14341 tcctgtataa gatcagtaca caatactggg atgtcgatcc gggactcttt cagcaggagg
    14401 aaaaattgca aaagacgatt ttcagtagat acacttacct gacagcctat atgaagacag
    14461 acaagtcgca aaagtatctt tataattacc gccctttctt ggaagcggtt tgtgaagatg
    14521 cctttttccg gaatgccgat gaagtgacga tgttggctcc cgatgggaag aagacgaagt
    14581 tggctgtcgc tgatctgcgt gccttggtcg cccagttacc gcaaatgccg gaagatgaac
    14641 gtttgaggcg cgagaagatg caggaacata ttaaaaaagc cagggaaaaa gaaaaggaat
    14701 tgcgtaaaag cggtgctaaa ctcgatacgc tcgccctgag taaggaagaa aaagagaaag
    14761 cacggaaaat gttgaaagac gccgacttgg aatagataga atagctgaac aatataatcg
    14821 atataaatat ggaatataga aaagtat
//
