LOCUS       c00019_gnlPro..        13553 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JGEPINEL_20.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 19:24:03
            Original ID  :: gnl|Prokka|JGEPINEL_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13553
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13553
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[325:3553]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      326..3553
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13553
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13553
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(326..1366)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="IlvN (E-value: 5.1e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYEGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(1427..1918)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1.1e-29, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(1931..3553)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.8e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSFLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(3750..4985)
                     /locus_tag="ctg19_4"
                     /transl_table=11
                     /translation="LKKIFLLLVTALFLLSLYGCNTSSSSNNPTEQTTVTNTDDLSLDT
                     DTDSETEFNYDLEIYYNDKKIDNLNLFDAFMPTEDGLIYSKINKDSPNEMEYYRYYLDK
                     KSSVKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMTTVF
                     SDKGGFPYDTVTGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNCVGKTIR
                     KVSIDDKTKTICLLVLDCVSETDVSLKIETYDYDMNFLKSYDISNISDDSNELIQGVQF
                     FDFRNNYLIYQNFSMTRCIGYIGNKKLQKSDMIDNIDDTYSMAQTPQKGYNTVLSFKDV
                     DLERNIYLFNTIDKTMKKTKFKPEEENYYIGSMSRTGKDNLMIITTPDNADKKSNLNPK
                     LYFTKLSDLKFQ"
     CDS             complement(5183..7507)
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCANCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKITETDG
                     FEDVSFNFATKLLNFKSKKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KINRDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMAVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGTEQVVPAESVEIGSIIEVKPYERVPLDGVIIKGKTTLDTSALTGESLPV
                     DASEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGILIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             complement(7520..7837)
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEVLNMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             complement(8040..8756)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MSETAKEPKKISKRSSEEKIEIIVAIFLGITALATAWASWIGSLH
                     GGNQATNYTKSNNLSSEGNSMWNEASQNLMQDMITWNDINEANLNYQYAESKNDKAEME
                     KYQYQIDQLMSDNCTEEFLEAINWAMDQKENVTPFMKDGYTESYFAEAQATIEESDKLL
                     EQGKKDNANGDAFGLVSVIYSVVLFMLGIVGTFKNLPNRRIVLGVAVAGFILATIYMFT
                     IPMPTGFNILSYFGMA"
     CDS             9440..10732
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRALGADIKKVYFTGDNEQELGA"
     CDS             10855..11643
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             11665..12150
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKSMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
ORIGIN
        1 ataacgcttt ttcttacgac aaatattgat tgtcaaaatt gataagattt aactgcaaaa
       61 gggttcagcc gtaaaaagct gaaccctttt attgcgcaac aaaaacggtt tagccaaatt
      121 gactgaaccg ttaattcgta ctatgtaacg ctcggatgac agaaatttga aaatatcaaa
      181 ctgtcttcac gaactgcgag cgaggtactt gcaaaaaggg tagcttgaaa atcaagctac
      241 cctaaattcg tactatgtaa tgctcgggtg acagaagttt gaatacatca aactgtcttc
      301 acgaactgtg tgcgagacac tcgcattagt tgttgatgag cttatcttcg tcagaccagc
      361 tgtagagctt tctaacttcc ttaccgaata cttcggcagg agcttcggca gcgatctttc
      421 tcatagcctt gaagtgaacc tgtgaaccgg catcgctcat gtcaaggagg aagtccttag
      481 caaatgtacc gtcctgaatg tcagaaagaa cctttctcat agccttctta gtatcctctg
      541 tgatgatctt tggacctgtg atgtagtcac cgtactcagc tgtgttagag attgaatatc
      601 tcatgcctgc aaaacctgac tgatagataa ggtcaacgat gagcttcatc tcatggatac
      661 actcaaagta agcgtttctt gggtcgtaac ctgcatcgca aagtgtttca aaacctgcct
      721 gcataagtgc gcaaacaccg ccgcaaagaa cagcctgttc accgaagagg tctgtttctg
      781 tttctgttct gaatgttgtt tcaagaacgc cggctcttgc accgccgata ccgagtgcat
      841 atgcaagtgc gagatcctta gcctgacctg tagcatcctg ctcaacagca acgaggcaag
      901 gtacaccctt accaacctga tactctgaac gaactgtgtg acccggtccc ttaggagcta
      961 ccattgtaac atcaacatcc tttggaggct tgatgcaacc gaagtgaatg ttaaagccgt
     1021 gagcaaacat aagcatattg cctgcttcga ggtttggctc gatgtcgttc ttgtaaagag
     1081 ctgcctgctt ttcatcgttg ataagaatca tgatgatgtc agcctgcttt gcagcctctg
     1141 ccgatgtata taccttaaag ccctgagctt cagcctttgc ccagctcttg ctgccttcgt
     1201 aaagaccgat gattacatcg caacctgaat ccttgaggtt gagagcgtgt gcatgaccct
     1261 ggctgccgta accgataata gcaattttct tacccttgag aaggtcaagg ttgcaatctg
     1321 actgatagta gattggtgct gtcatgttct tagtgtagtc tttcatatta aagtcctcct
     1381 taccgcaaac gcggcatata aattagaata tatgctaact gtaagattaa acggaaaccg
     1441 aagctgtgcc tctgtcaatg gcaacagtac ctgttcttac aatctcacgg ataccataag
     1501 gcttgagtaa gtcaacaagc gtgttgatgc ggcttgcaca ttcgcagtac tcaacggtaa
     1561 ctgacgaagg ggatacatca acgattttcg cctgcataat ttcaaccgtt ttgacaattt
     1621 cggctctttt tgaggcggcg cagtgaacct tgattaaaac aagctcacgg ctgataaatt
     1681 cgccctcgtt aagccttttt accttaataa cgggaatgag cttgttgagc tgtttttcaa
     1741 gctgttcaac aatgtactcg tcaccgtttg caacgattgt gattcgggaa accgacgggt
     1801 cctgagtaac acctactgca agtgagtcga tgttaaagcc tcggcgagag aaaagtcccg
     1861 aaatctttga aagaacgccc gcctgatttt caacaagtat tgataatgta tactgcattt
     1921 tatcacctca ttaaattgac ggagtgtcgg ggtgaacatc gcaaacaaga atgaacggtt
     1981 tttctgaatc aacaataccc ttgatgatgt tttcggcttc cttgtttgaa tgagcctctg
     2041 catggtcaat gccgtaagca tcggcaatct tcaagaagtc gggatcaccg ttgagaattg
     2101 ttgcggagtg tctgccgccg tagtgcttgt cctgaagttc acgaaccatt ccgagtcgtg
     2161 cgtttttcat aatgatgatt ttaattccga gctgattgcc tgcaatagtt gcaagctcat
     2221 taagccccat ctgaaaactg ccgtcaccgc agattacaat aacatcacgg tcgggtcttg
     2281 caaactttgc accgattgcg gcgggaattg agtaacccat tgtacccata ccgcctgttg
     2341 tgaggaatct gccctcacga atacggaagt tgtttgcaca ccagatttga ttttgtccta
     2401 catcggcaac gagaattgcc tttgagcgga acattgcact gagatgaccg acaagtgttc
     2461 tcggctcaac aaagccgtca aaaacgggag gctcacggta aaggtctttt ttccagttct
     2521 ttacggtttc gctccacatt gttgtaacct tgtaatcgcc gatgctgtca agcagcatat
     2581 tgatgacatt tttcatatcg cctacaatcg gaatttctgt tttaacattc ttaccgattt
     2641 cagcagggtc aatgtcaatg tgaattacct ttgtgttttc actcatctgg tcgggagccg
     2701 caacagctct gtcaccgagt cttgcaccgc atacgattac aaggtcggct tcgtggagag
     2761 cacggttggc aacagccttg ccgtgagtgc cgagcattcc gagataaagc tcatgctcgc
     2821 tgggcataac accgatgccc atcatagttg aaataacggg gatacccgta gtttctgcaa
     2881 atttttgaag tttaagcttg atacccgaac tcagcacgcc gcctcctgat acgataacag
     2941 gacgcttgct tgcgttgatg gcctcaacag cctttttaac ctgaattgcg tgtcccttag
     3001 tgttcggctt gtaaccgata atgtttacgc tttcgggata ttcaaaactt tcaatttcat
     3061 tttcctgaat atcaacggga atgtcgataa gtacaggacc gggtctgccg gttgaggcaa
     3121 tatggaaagc ctctttgaaa actctcggaa ggtcttctgt tttgctgacg agaaaactgt
     3181 gctttacaaa cggttcacaa gctcccgtga tgtcagcctc ctgaaagaca tctctgccga
     3241 gaaggtcgga acgaacctga cctgtaatgg caacaatcgg aatagagtcc gtataggcgg
     3301 ttgcaatgcc tgtgatgagg ttggttgcac cgggaccgga agttgccacg caaacaccgg
     3361 gacgattact gcatcttgca tagccgcttg ccgcatgagc agcgttctgt tcctgacgaa
     3421 caagaatgtg ggtaatgctc gaatcgtaaa ctttatcgta aaatgggcag atagccgcac
     3481 cgggataacc aaagactatg tcaacgccct cggcttccaa acattttacc ataatttcag
     3541 caccgctgat cattatgttt tgtccctcct atccttttta ttgtgagcaa aaggtgtttt
     3601 gtaacattaa atataccttt ttgctttacc gctaattata caataaatac cttaaaaagt
     3661 aaagagcagt attgcccata aattaaattt tttgcaggat tttgacagat aatttgcaaa
     3721 atggatttta attgattttt accgcctgtt tactgaaatt ttaagtcgct taattttgta
     3781 aagtatagtt ttggattaag attacttttt ttgtctgcat tatcaggagt agttattatc
     3841 atcaaattat cttttccagt tcttgacatt gagccgatat agtagttttc ttcttcaggt
     3901 ttgaattttg tttttttcat tgttttgtca atggtattaa ataagtatat attccgttct
     3961 aaatcaacat ctttaaatga taaaactgta ttatatcctt tttgtggagt ttgagccata
     4021 gagtaggtgt cgtcaatgtt gtcaatcata tcggattttt gcaatttttt gttccctata
     4081 taacctatac atcttgtcat actaaaattt tgatagataa ggtagttgtt tctaaaatca
     4141 aagaactgta caccttgaat cagttcattt gaatcatctg aaatgttgga tatatcgtag
     4201 cttttaagaa aattcatatc atagtcatag gtttctattt ttaaagaaac atctgtttcc
     4261 gaaacacagt ccaaaaccaa gaggcagatt gtttttgttt tgtcgtcaat tgaaactttt
     4321 cttatagttt ttcctacaca gttcttatca tcaaactcta aatatttcag ttgtttaaac
     4381 ttttgcgttt cggtgtcata cagttccaaa gaagtaccgt tgtttaatac ttttgtaatt
     4441 atgacaagat tgtctgctcc tgtaacggta tcatagggaa aaccgccttt gtcagaaaag
     4501 acagtagtca ttttgttttt attaaggtct atatcaataa attcaagggt tctgttttct
     4561 tcgtcggtaa tgtcgcccgt gcttgccata aaacataagt gattatttac atacgcttta
     4621 tcgttaattt gcattgtcca gtcttttatt gagccgagtt ttacactgct ctttttgtct
     4681 aaatagtatc tgtaatattc catttcattt ggagagtctt tattgatttt tgaatatatg
     4741 agtccatcct cagttggcat aaatgcatcg aaaagattta aattatcaat ctttttatcg
     4801 ttatagtaaa tctccaaatc gtaattaaat tctgtttcag aatctgtatc tgtatcaaga
     4861 gataaatcat ctgtattcgt tactgttgtt tgctcagtgg ggttattgct tgatgaagaa
     4921 gtgttacatc catataatga aagtaaaaat aaagcggtta ctaataataa aaatatcttt
     4981 ttcaaattaa tctctccgaa gtttatttat cagttacaag cactgacaaa aatattataa
     5041 tttatataat tataaaagtc aatgatttta aaatactata atataagatt atgtttagaa
     5101 aaattttggc aaacgaaagc accgtgaaac ttgtgaaagc tcacggtgct ttatcataat
     5161 aaatgatatg atttgcaaaa aatcaatatt tctttttgag gagtcttgcg gctatgagga
     5221 cgcagactac gctgacgcct gtgtcggcga taacggacat ccagatttgt gcaagaccga
     5281 atgcggcgag gatgattaca agagccttga ttgagagggc gaagatgatg ttgcccttga
     5341 cagtgttgat aacacttctt gcaattttaa ttgcctttgg aagctgtttg agtgtgcctg
     5401 atgcgagaac tgcgtctgac gcttcaatag cggcttcact gccgaatccc attgcaatac
     5461 cgcagtcgct tgccgaaaga acaggggcat cattgatgcc gtcgcctaca aagcaagcgc
     5521 ccttggattt tgatttcaaa cccttgaaaa gctcaagctt ttgagcaggg agaagctctg
     5581 cgtgacattc ggaaagtccg agttcgtttt taacattttc ggcaggctgt tgtctgtcgc
     5641 ccgtgagcat taccgtgttc ttgacaccga gcgctttaag ctgtgagata acctcttttg
     5701 cctcaggtct tactgtgtcg ctgacattga gcgaaccgat aagctgaccg tcataaatta
     5761 cgaaaacaga atcgtcttta tttgcaatct tcttctgttc gtccgaaaga atctttgaac
     5821 cgccgcactg aatagttttg ccgttataaa ctgcgcttgt tccgtgaccg gcactttcgc
     5881 tgtagtcgga aagctcggga agttcaagac cgtttgcctt ttctctgatt gcggaggcaa
     5941 tcggatgagc agaatatttt tcgcttgcag cggcaagagc aagaacttcg tcggcactgt
     6001 atgaaccgac cgtattaacc ttgtttacgc tgagctttcc gcttgtgagc gtgcctgttt
     6061 tatcgaatac gaatgtgtct gcttttgcaa gagcctcaat atattttccg cccttgatga
     6121 gtatgccgac ttcggatgcc gcaccgatac ccgaatagta ggagagaggt acggaaataa
     6181 caatagcaca cggacatgac gctacaagac aaacaagcgc acggtagagc cattcgctga
     6241 atgctccgag tccgcaaagc ggaggaatta ctgcgattgc aactgcaatg agtacaacaa
     6301 ccggtgtgta aacagaggca aatcttgaaa taagcttttc gctgttgccc ttttgagcgg
     6361 cggcatcttc aacaagctga agaattcttg ttgcggtact gtcgccgaaa tgctttgtgg
     6421 ttttgacagt aataaggtta ctgccgttga ttgcaccgct gagtacctca ctgccctcgc
     6481 ttgcgtcaac aggaaggctt tcgcctgtga gagccgatgt gtcgagagtt gttttacctt
     6541 taataataac gccgtcaagc ggaactcttt cgtatggctt gacttcaatg atacttccga
     6601 tttcaacgct ttcggcagga acaacctgtt ccgtaccgtc aacaataatt gttgctgtat
     6661 cgggacgaat gtttgcaagc ttttcaatgt cacggcggga tgcgtcaact gctcgatcct
     6721 caaaaatttc accgatagaa aagaggattg ttaccattgc cgcctcaaca aaatctccaa
     6781 gacagaatgc cgcaattacc gcaacagcca taagcgttgt ttcgtcaatt ctcagcttta
     6841 gaatgttttt tgcacccttg ataaatacct tgtaacccga aagaagtgtt gcaacaaaac
     6901 acgctgcgag tacaacataa tgaacagccg taacaccgtc aagtgtaagg tggagaattt
     6961 cggacactac agcaagtaca attgaaattg caaggaagat tgtgtcacgg ttgattttct
     7021 ttttcgtgat ttcgggttct gcctttgttg tgatatcatt tttcggagtt ttgtcaacaa
     7081 cagttacacc gtcctcaatg ctgtcgcaga ttgcttgaat ttcggaaaca ggattctgct
     7141 ttttgctttt gaagttgaga agttttgtcg caaaattaaa gcttacatcc tcaaagccgt
     7201 ctgtttctgt aattttagcc tcaattttgc ccgcacaatg agcacaattg agattgtcta
     7261 aagtgtaggt gtattttttg agattggttt tcggagtttt gtcaacaacg gttacaccgt
     7321 cctcaatgct gtcgcaaatt gcctgaattt cggaaacagg attctgcttt tcgcttttga
     7381 aattgagaag ttttgtcgca aaattgaagc tcacatcttc aaagccgttt gtttctgcaa
     7441 ttttagcctc aatcttgcct gcacaattag cgcagttgag attgtcaagc tgatatttgt
     7501 acctcatatg tttccctcct tattcaagaa catggtcaag tcccatttct atgattcgtt
     7561 tcacatggtc atcgtcaagg ctgtaataaa tctgctttcc ttcacggcga acacgcacca
     7621 gcttgttctg ccttaacaca cgcagttggt gagaaattgt gctttgctcc atgttgagga
     7681 cttcagcaat gttgagcacc gacatttcat tttccgaaat ggtgtacata atgcgaagtc
     7741 gggttgaatc accgaaaacc ttaaaaaggt ctgcaagctc aaacagcaca tcaatgtcgg
     7801 gcatttcggg agtggttgtt ttttctttgt tttccatagg cgtccccttt aattttctct
     7861 caggttaaaa gttatacttg aacatatgaa gatatgctca tatgttaatt ataatatagc
     7921 attccctttt taaaaagtca atagacatag aggaaaaagt gtaatatttt tttgattctt
     7981 tacaaaaaac agcggcaaaa gcatttgctt tcaccgctgt gagtacagaa tattttgttt
     8041 tatgccattc cgaaataact gagaatattg aatcctgtcg gcatcggaat tgtaaacata
     8101 tatatagtgg caagaataaa acctgcaact gcaacaccga gcacaattct tctgttcgga
     8161 agattcttga atgtgcctac gataccgagc ataaagagta caaccgagta aattacgctt
     8221 acaagaccga atgcgtcacc gtttgcgtta tctttcttac cttgttcaag aagtttgtcc
     8281 gactcttcaa ttgtagcttg tgcctctgca aaataacttt cggtgtaacc gtccttcata
     8341 aacggagtta cattttcctt ttgatccatt gcccaattaa ttgcctcaag aaattcttct
     8401 gtacagttat cactcataag ctgatcaatt tggtactgat atttttccat ttccgcttta
     8461 tcgtttttag attccgcata ttggtaatta aggtttgcct cattgatgtc attccatgtg
     8521 atcatatcct gcataagatt ttgagaagcc tcattccaca tcgagttgcc ctctgatgat
     8581 aggttgttgc tttttgtgta gttagtcgcc tgatttccgc cgtgaagtga acctatccac
     8641 gatgcccatg ctgtggcgag tgcggttatt ccgagaaaaa tcgcaacaat aatttcaatt
     8701 ttttcttcac tgcttctttt acttattttt ttcggttctt ttgctgtttc gctcattctg
     8761 aatcccccgt taattaaaaa tttgccgcaa tgccttaatt ttgtcgttat tatattgtaa
     8821 aaggacactt gccgactgat tctgtttcaa tcataattga taaaagtttt aaattcaatg
     8881 caagtggcag taaagtcttt ttttaggcat aataatcatt ttgtctgtga tttttaaaaa
     8941 aatttacctt tagatatttt tgttttattc gtttgatttg caaagaataa atatatacga
     9001 tagatttgcc tgcaaatttt caattaagaa aatataataa ctgtttcaat ttgtaattat
     9061 tttacaaaaa aattgcttta attaattact tctttttagg aaaaaacggt tttaaaaagc
     9121 atggttggtt atattaaaaa caaaaaaagc aacaaattaa taatttgagt acaacttgcc
     9181 caaaaataga ttacagtttt attattccgt tgactttact acaattttgt agtatcattt
     9241 tctgtaagag aattgttaaa ttacatctgc gtaaccgagt gggttcgttt ttaataaaat
     9301 gtaacaaatt agttctcatt atgaatttta gattcgtata atttttgatt tttacttata
     9361 cactatatag atatacattt tcggatattt agcttattta gttaaaagta tcctctacac
     9421 attaattggg gtgtaacaat tggagaagtt cgtagttacc ggcggaaagc cattatcggg
     9481 tgaagtgaca atcagcggtg cgaaaaatgc agccgttgca attattccgg cagttattct
     9541 ttgtgatgag ccatgccaga ttgaaaatat tcctaacatc agcgatgtat cacttatcag
     9601 cagaattctt cagcagatgg gtgctaatgt aagacgaatc aaccgttcgt ccttatatat
     9661 tgatcctaca aaaatccgca catgcaatgc tgtgaccgac cttgtaagag gtatgagagc
     9721 atcatattat cttctcggcg cacttttggg caagtacggc aaggctaagg tggctcttcc
     9781 gggcggctgt aactttggcg tgcgtccgat tgaccagcat cttaaaggtt ttgaggctct
     9841 cggtgcgaca actcagcttg ttgacggtgc gattatagag gcagaatgcg acaaccttgt
     9901 cggtacacat gtgtaccttg atgttgtgtc cgttggtgca acaatgaaca ttatgcttgc
     9961 cgcatcaaag gcaaagggac agaccattat tgaaaatgcc gcaagagaac cgcatattgt
    10021 tgaccttgcg aacttcctta attcaatggg tgcggatgtc aggggtgcag gtacggatgt
    10081 tatcaaaatc cgtggcgttg agtatcttca cggcattact tattcgatta ttcccgacca
    10141 gattgaggca ggaacatata tgtgtgccgc cgccgcaaca agaggttgta taacggtaaa
    10201 gaatattaca ccgaagcatc ttgaatcaat cagcgcaaag ctgcgtgaga tgggtgttaa
    10261 gattacggaa tatgatgagg ctctcaaggt tgatgcgtca tctgctccgc taaagcgctg
    10321 taatatcaag acaatgccgc atcccggctt tccgacagac tgtcagccgc agtttgctgc
    10381 attgcttatg agcgttcccg gaacaagcat catcaacgag aatgtttggg ataatcgcta
    10441 tcagtatgtc agcgagctta tcagaatggg tgcgcagatt tctgttgagg gcagacttgc
    10501 aatcattgag ggcggtgttc cgctcacagc ggctcccgtt aaggcaaccg accttcgtgc
    10561 aggtgcggct atgattattg ccgctcttga aattaacggt acaacagaga tttcaaatat
    10621 tcagttcatt gagcgtggat atgaagatgt tgttgaaaag ttcagagcac tcggtgcaga
    10681 tatcaaaaag gtgtatttta caggagataa cgagcaagag cttggtgcct gactaaaatt
    10741 taattagaaa tcaaagccgt tttctttgtg agaacggctt ttttgtgaga taatttacaa
    10801 attttaaaat ttgtgttatc atattcgtta tactaaagat aaggattgat tgttttggca
    10861 agagcagtac cgctgttcag cggaagtaag ggtaacagct actacatagg ttcggcaagc
    10921 gaaggcgtac tgattgatgc aggtcgttca tgcaagcaga ttgaaaatgc catgcttgca
    10981 aacggacttg atatgggcag tatcggggcg gtttttataa ctcacgaaca cacagaccat
    11041 tgcagtgcgt tgcgtgtgct tgcaaagcgt tacggcttta aggtgtattc aagtctcggt
    11101 acgctcaatg ctttgagggc aggtaataag cttgatccaa acacggatgc agatgttata
    11161 actgacgagg ttgtaatcgg caatatgcgt gttcagcgaa ttgacacccc ccacgatgcg
    11221 gcggaaagct gttgctaccg tgttactgct cccgacggaa aatccgcact tatagcaacc
    11281 gatatgggtg ttatgctgcc cgatgtaaga actgccgcag agcagagcga ctttgttgtg
    11341 cttgagtcaa atcacgatat caatatgctc aaaaacggat tttatcctta tccgctaaag
    11401 cagagaatcc tttcaaacag aggacatctt tcaaatgagg cgtgtgcaaa agaacttgtt
    11461 aaccttgttg aaaagggaac tttaagactt atgctcggcc atctcagcga agaaaataat
    11521 accgttccgc ttgcaatgtc aacatccgta gacctgctca catcaaacgg aatgaagtac
    11581 aaaagcgatt attcgcttga tgttgcaccg agtgtaagca caacaaaagc catcatcttt
    11641 taaccttaaa caaacaagag aaatatgatt aagattaaca taatttgtat cggcaaaata
    11701 aaggaaaaat attttaccga cgcaattgca gagtatgcaa aacgcttgac cgcattttgt
    11761 aaattcaata ttattgagct ttcggaagaa cgcattaaga gcaacatacc gaatcggtca
    11821 cagattgatg aggttatttt ctctgaggga aaacgaatca tgcaaaaaat ttcgccttcg
    11881 gattatgttg ttgcaatgtg tattgaggga aagtctatgt cgagtgagga gctttcaaag
    11941 ctgattgaca atgcgtccgt aagcggaaaa agcaccgttg attttattat cggcggcagc
    12001 tacggacttg acgaatcggt taaaaaacgg gcagatgtcc gtctttcaat gagcagaatg
    12061 acctttcctc accaaatggc aagaatgatt ttaagcgaac agatttaccg tgcatttgaa
    12121 atttcatcaa acggtaaata tcacaaataa tttacggagt tactatggcg cttgacggaa
    12181 tttttttaag acatattaaa agtgaaatag aaaaagaggc tctcggtgca agggtgtcgc
    12241 agatttatca gccgaacaga gaagagcttg tgttcggact gagaacattt tccggcaaca
    12301 aaaagctgtt gctttctgca cgagcaaatt caccgagagt gaacttctgt tcgtcaacac
    12361 ccgaaaatcc tgcacaacct ccgatgttct gtatgctttt gcgaaaaaga atcggcggcg
    12421 gaaagcttgt gggacttcgc cagaacggtt gcgaccgtgt tcttatgctc gatttcgagt
    12481 gcgtgaacga actcggcgat actgtgatga taactgttgt atgcgaaatt atgggtatgt
    12541 acagcaacat aattattgtt gattcaaacg gcgtcatcat cgattcacta aagcgtgtag
    12601 atcttacaat gagcagtaaa agacttgtac tgccgaatat aaaatacgaa cttcccgaat
    12661 cgcagaacaa gctgaatctg cttaaatgtt cggcgcttga tgtgtgtaca gccgtaaaga
    12721 atcttgacac ggaaatgccg cttaacaagg cgctgttaag gacaattgag ggcgtttctc
    12781 caattgtatg ccgtgagatt gaatacaagg ttatggaggg cgcaacaaac agaattgagg
    12841 gtgtgctttt tgaccgactc gcagttgaaa tcgaaaagct gaaaagcgtt tgcagcgatt
    12901 gttcgggcaa gcctgttgtg gtttatcgtg aggacggcaa gcccatggac ttctgcttta
    12961 tgaatgttga gcagtacggc gattttgcaa aggttgagag taaggaaagc ttctccgatt
    13021 tgcttgacgg attctatgaa gctcgtgaca gtcgtgacag aatgagggtg aaatcacaaa
    13081 gccttacaaa gcttttgaac aacacacttg aaaggcttgc acgaaaaatt gcaaagcaga
    13141 agagtgagct tgaacgctgt gcagaccgtg agcatcttcg catatgcggt gaccttttac
    13201 aggcaaatat ctatcgcatt gagcgtggtg cggagtatgt tgatgttgaa aacttttacg
    13261 atgagaacaa cgcaatttta cgcataaagc ttaatccggc aatctcacct tcggcaaatg
    13321 ctcagaagta ttacaaggat taccgcaagg ctaaaaatgc cgaaattatg ctcaaagaac
    13381 agcttgaaaa gggcagggaa gagcttgatt atattaactc tgttctcgat acggttgacc
    13441 gtgcggaaaa tgaaaaagac cttgcacaaa ttcgtgagga gcttaccgaa cagggctatc
    13501 ttaaggttca aaaaggcaaa aagccccgtc agacaacttt gccgccgctc gaa
//
