LOCUS       c00008_gnlPro..        17267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FFFLGJHJ_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 19:58:55
            Original ID  :: gnl|Prokka|FFFLGJHJ_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17267
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1011
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="PLQIFLHKDEGHWLNGQPEAEDKESFQVGNRWFKPNYHAHVVFDW
                     MNHETGKSRKLNDEDMATMQTLASDILLMERGQAKAVTGKEHLERNDFIIEKQKAELQR
                     IEETKRHKEQQVSLAEQELKQVKAEIRTDKLKKTATNAATAIASGVGSLFGSGKLKELE
                     HHIEQLHQEITKRDKATDELKIQIQQIQEQHSRQIRNLQRIHNQELEAKDKEISRLSTL
                     LEKAHKWFPMFKEMLRMEKLCAVIGFTKDMIENLLTKKESIQCSGKIYSEEHRWKFDIK
                     NDIFRVEKHPMDSGKLMLTINRQPIVQWFKEQWEKLQQNLRNSVQREQKSRGFRI"
     protocluster    1..17267
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4308:7267]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4309..7267
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..17267
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17267
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             1100..1453
                     /locus_tag="ctg8_2"
                     /transl_table=11
                     /translation="MKPKEVLEKWIDCFNKADAYHIAELYATNAVNHQVANEPIIGKES
                     IYKMFVNEFATAKMVCMVENIFEDGEWAIMEWKDSLGLRGCGFFHVKDNKIVFQRGYWD
                     KLSFLKQHNLPIE"
     CDS             complement(1901..2413)
                     /locus_tag="ctg8_3"
                     /transl_table=11
                     /translation="MTKKEHTTITELFQVLDLLESLDMQFWLDGGWGVDVLYGQQTRLH
                     RDIDIDFDANYTDQLLDLLQERGYQIETNWLPTRVELYSKELGYIDIHPFVLNADGTSK
                     QADLDGGWYEFQPDYFGTAVFEGRSIPCISAKGQQVFHSGYDLREKDIHDLSIIKQCIT
                     TMSLTIR"
     CDS             complement(2438..3331)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 50.5; E-value: 5e-16)"
                     /gene_kind="transport"
                     /locus_tag="ctg8_4"
                     /sec_met_domain="MFS_1 (E-value: 4.5e-16, bitscore: 50.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTACRSIGSTFHAPALQASIPLLVPKHHLVRVSGLYHSIQSFSEV
                     IAPVVGASLVVWLPIQYILLIDVIGAVAACLTLLCVQIPSLQKTKVLPDFKKELTECWH
                     TLRRTMGILPLFVCFTLVTFVLMPVFTLFPFMTLLHFNGNILQMGVVEMGWGSGALLGG
                     LVLACKALKSKQTLVMHTAYVILGLYLISASYLPSSAFIGFVCLTFTGGIAYSIYHALF
                     IAIIQQNLASDMLGRTFSLIFSLSTFPSMLGIVASGYWVEAWGITSVFMISGWVIFLIG
                     VGANFISSIKQLDNYA"
     CDS             4309..6537
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_5"
                     /sec_met_domain="Gly_radical (E-value: 2e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1165.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANFAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             6542..7267
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_6"
                     /sec_met_domain="Radical_SAM (E-value: 2.7e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(7500..8762)
                     /locus_tag="ctg8_7"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKRPEAVTEEKRTEPQQEATAAIE
                     KKESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(8814..9362)
                     /locus_tag="ctg8_8"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             9550..10302
                     /locus_tag="ctg8_9"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(10407..11405)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg8_10"
                     /sec_met_domain="LysR_substrate (E-value: 1.4e-46,
                     bitscore: 150.3, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.2e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMELKTPDIRKALLTG
                     EVDAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             11475..11948
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(12052..13050)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_12"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.3e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(13105..14373)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_13"
                     /sec_met_domain="MFS_1 (E-value: 3.5e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(14623..15636)
                     /locus_tag="ctg8_14"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTVALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(15659..16768)
                     /locus_tag="ctg8_15"
                     /transl_table=11
                     /translation="LLACFVLPMILAGCNDADYQVIDNAIYLNEASENGSAKVTVDPEN
                     VTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTYDKEIKIAAG
                     DVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDKPLIQSVPFM
                     NTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVYIRFGDAMIP
                     YNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQTKGGPVRFD
                     KMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGYWKMDEGKGN
                     AFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 ccgctacaga ttttcctgca taaagacgaa gggcattggc tgaacggtca gccggaagca
       61 gaagacaagg agagcttcca agtcggtaac agatggttca aaccaaatta tcatgctcat
      121 gtcgtattcg actggatgaa ccatgaaact ggaaagagcc gaaagctcaa tgacgaggat
      181 atggcaacca tgcagaccct tgcttccgat attctcctga tggaacgtgg acaggcaaaa
      241 gctgtcacag gtaaagagca tctggaacga aatgatttca tcattgagaa gcagaaagcc
      301 gaactgcaac gtatagagga aaccaagcga cacaaggaac aacaagtaag ccttgccgaa
      361 caggaactca aacaggtaaa agcagagata cgcacggaca aactaaagaa aacagccacc
      421 aatgctgcta ccgccatagc aagcggtgta ggttctcttt tcggaagcgg taagctgaaa
      481 gaactggaac atcacatcga gcagctacat caggaaatta ccaaacggga caaagctact
      541 gatgaattaa aaattcagat acaacaaata caggaacagc atagcagaca aattcgtaat
      601 cttcaaagaa tacataatca agaacttgaa gccaaagaca aggaaatatc acgattgagc
      661 accttgcttg aaaaagccca caaatggttt cccatgttca aagagatgtt gagaatggaa
      721 aaattatgcg ctgttatcgg gtttaccaaa gacatgatag aaaacctctt gacaaagaaa
      781 gaatccatac aatgtagtgg caaaatttat tccgaagaac acaggtggaa atttgacatc
      841 aagaatgata tttttagggt tgagaaacat ccgatggata gtggtaagct tatgctgacc
      901 ataaaccgac aacccatagt acaatggttt aaggaacaat gggaaaagtt acagcagaat
      961 ctacgtaact cggtgcagag agagcaaaaa tccagaggat ttagaatata gaatagccta
     1021 ttattaataa aatcaagtat ctatgcatcc aaacagattg tttttattac agaatcaaaa
     1081 tcctaagaat ttataaaaaa tgaagcctaa agaagttttg gaaaaatgga tagattgctt
     1141 taacaaagca gatgcttatc atatagcaga gctgtatgct actaatgcag taaatcatca
     1201 agtcgcaaac gaaccaataa taggtaaaga atcaatctac aaaatgtttg tgaatgaatt
     1261 tgccactgct aaaatggttt gtatggtgga aaatattttt gaagatggcg aatgggctat
     1321 catggaatgg aaagactctc ttggacttcg tggatgcgga ttttttcatg taaaagataa
     1381 caaaatcgtc tttcaaagag ggtattggga taaactttca ttcttgaagc aacacaatct
     1441 tccaattgaa taagtactat cagaatacgg actgggaaat tgaaataccc agtccgagtt
     1501 atataatgaa ttttacttgt taaactattt aaagtcagtt ggataacaaa ccataccttt
     1561 cacattctca gtagctccag gtattaattc agccaccatg caatattcat gagagacttc
     1621 gaaaggaaat tcaattccta aatcgatagc cttgcgatag ccaaatcgag gataatactc
     1681 tttatgcccc aatacgactg ctgtgccgta acccaaaagt gctgccctct gatgggctta
     1741 ctgaatcaac atcccccccc caattccctt acgctggaat tccggcaaga ctgccaatgg
     1801 agctacactc agggatgtga cagactgggt gtcactgtct atctttactt ctgtaagtaa
     1861 gatataccag acaatttgtt tttctgtcat tttcttgttc ttatctaatt gttaggctca
     1921 ttgttgttat acattgttta attatagata aatcgtgaat atccttctct cttaaatcgt
     1981 agcccgaatg gaatacttgt tgcccttttg cagaaatgca agggatgctt ctgccttcaa
     2041 agactgctgt tccaaaatag tccggttgaa attcatacca gcctccatcc aagtcggctt
     2101 gtttggaagt gccgtccgca ttcaagacaa aaggatggat atcaatatag cctaattctt
     2161 tgctatacag ttccacacgg gtgggcaacc aatttgtttc aatttgatat cctctctcct
     2221 gcaaaagatc aaggagttgg tctgtataat tggcatcaaa atcaatgtca atatctctat
     2281 gcaagcgggt ttgctgtccg tacaagacat ccactcccca gcctccatcc aaccaaaact
     2341 gcatgtccag gctttccaac aagtccaaaa cttgaaataa ctctgtaatc gtagtgtgtt
     2401 ctttctttgt catataataa ttctttaata aataatacta tgcgtaatta tccaactgct
     2461 tgattgaaga aataaaattt gcacccactc caatcagaaa gataacccat ccgctgatca
     2521 taaagacgga tgtgataccc catgcttcca cccaatatcc tgaagctacg atacccagca
     2581 ttgatggaaa ggtactcaaa ctaaagatga gagaaaaagt ccgtccaagc atgtccgaag
     2641 ccaagttctg ctgaataata gcgatgaaaa gcgcatggta aatggaatag gctatgcctc
     2701 ctgtaaatgt taggcaaaca aaacctataa atgcgcttga tggtaaataa ctggcgctaa
     2761 tcagatacaa tcccaatatc acataagccg tatgcatcac taatgtttgc ttgcttttca
     2821 aagccttaca ggcaagtact aaaccgccca acaatgcccc tgagccccaa cccatttcca
     2881 caactcccat ttgcaaaatg tttccgttga aatgcagaag cgtcataaaa ggaaataacg
     2941 taaaaacagg cataaggaca aaagtcacca gcgtaaagca tacgaataaa ggcaaaatgc
     3001 ccattgtacg ccgcaaggta tgccaacatt ccgtcagttc ttttttgaaa tctggaagaa
     3061 ctttcgtttt ttgaagagaa ggaatctgga cacaaagtaa ggtcagacaa gcagcaacag
     3121 ctccgatcac atctatgagc agaatatact gtatgggaag ccaaacaacg aggcttgccc
     3181 ctacaacggg agctatcacc tcactgaagg attgaatgga atggtacaaa cctgataccc
     3241 tgacaagatg gtgcttggga accagtagag ggatgcttgc ctgtaaagca ggtgcatgaa
     3301 acgtactgcc tattgaacga caagcagtca atagataaaa aaaagaaagg tctttataac
     3361 ccttggttat cacaataaaa agacataggg tacagaacgc gatgaacaag tccgaataaa
     3421 acatcgtttt ctttcgattc catctgtcaa catagacccc ggcaaacaag cctaatacaa
     3481 attgtggtaa aaatccagct aaaatagcca gagataaagc tgtcggggat ttaaattcgt
     3541 tgctaatcca aaaaataatg gagaagccaa caatcgtact tgttaaaata gatatgagtt
     3601 ggcctattcc tatcacggcc aaagttgatt tccaatgatt cattgtgcta atatttcatg
     3661 cgtttataga taagtacttt cgtacattaa gcaaaacgaa attctatcca cacaaaaaac
     3721 ttgtattata atccactcct gacgttggaa tacaataaca aatactttca ggacgatgta
     3781 aagtcctgaa aaatcaaact gaatggatag ataaatatta gtcttttctc atcggattct
     3841 tttaatatcg ctactctttt attatgtagt ggttgtatta tcttaaataa aacaaaaaca
     3901 ccgactttac attcttgggt gtaaaactgg gtgtttgttt tgcaatctgc tgattttcag
     3961 cgtttgttgc ggagagacag ggattcgaac cccgggtacc tcgcagtaca acggttttca
     4021 agaccgccgc aatcgaccac tctgccacct ctccagaact acggttaagt agtgcttttc
     4081 tcttaaagcg ctgcaaaggt acgaatcatt ttttaacttg caaattattc cgcaaaaaaa
     4141 tattagaaaa gtatatttgg aagtaataac tgctatctag cttctcccca taaataggta
     4201 tttttatgct attcaacata aaataggacc cttttatata cctaaaccga aaaaaggttg
     4261 taaatttgcg cgctctaaag gataactaac cactaactga ttaattttat ggaactgaat
     4321 aagaccttta aagatggact ttggagcaaa gaaatcaatg taagggattt cgttagtaac
     4381 aacatcactc cttatgaagg ggatgcttct ttcctgcaag gacctaccga acgcaccaaa
     4441 gctgtctgga atcactgtct caaagctctc gaagaagaga gaaacaataa tggtattcgt
     4501 gcactcgact acacaactgt atctactata acctctcacc ctgccggcta catcgataaa
     4561 gagaacgaac tgatcgtcgg actacagacc gatcaggtat taaaacgtgc catcaaaccg
     4621 tttggcggaa tcaatgtggt tatgaaagct tgccgtgaaa acggagtgga agtagatgac
     4681 agagtcaagg atatcttcac tcactatcgc aagactcata atgatggggt attcgatgtg
     4741 tataccgaag aaattcgttc gttccgttca ttgggattcc ttaccggact tcccgacaac
     4801 tatgcacgcg gacgtatcat cggtgattat cgccgcctgg ctctctatgg tcttgaccgt
     4861 ctgatagaag ctaaaaaaga agatctgcat aatctgacag gtcctatgac tgaagcccgc
     4921 attcgtcttc gcgaagaagt agccgagcaa atcaaggccc tgaaagagat taaagtattg
     4981 ggcgaatatt atggtttgga tctgagccga ccggcatata ccgcacagga agctgtacaa
     5041 tgggtgtata tggcttatct ggctgccgta aaagagcagg atggtgctgc catgtcactg
     5101 ggtaatgtat cttcattcct cgacatctat cttgaatatg aattaagcca gggtacgata
     5161 accgaaacat tcgctcagga actgatcgac caattcgtta tcaaactccg tatggtacgc
     5221 cacttgcgta tgcagtcgta caacgatatt tttgcgggtg atcccacatg ggtgaccgaa
     5281 tctatcggtg gacgtttcaa tgatggacgt accaaagtta ctaaaacttc tttccgcttc
     5341 ttgcagacac tttataactt aggcccgtca ccagaaccta acatgactgt actatggagc
     5401 cctgagttac ccgaaggttt caaagcattc tgtgcacaag tatctatcga cacttcttcc
     5461 gtacaatacg aaaacgacga cctaatgcgt gaagtccgtc aatcggatga ctacggaatc
     5521 gcttgttgtg tttcatatca ggaaatcgga aagcagattc agttcttcgg cgcacgtgcc
     5581 aactttgcca aagccctgct actggctatc aacggaggac gttgcgaaaa tacaggtaca
     5641 gttatggtaa aagacatccc tgtattgacc ggtgaaacac tgaagttcga agaagtaatg
     5701 gccaactata agaaagtatt gatacaaatt gcacgtgtat acaacgaagc aatgaatatc
     5761 atacattaca tgcacgataa gtattactac gaaaaggcgc agatggcttt cgtggatact
     5821 gatccccgca ttaacctcgc ttatggtgta gccggactct caatcgccat cgattcactg
     5881 tccgccatca aatatgcaca tgtgaaagcc cgccgcaacg acatcggact gacggaggga
     5941 ttcgatatcg aaggtgcttt cccttgtttc ggtaatgacg atgaccgtgt agaccacctg
     6001 ggtgtggacc tggtatattt ctttagcgaa gaattaaaga aactccccgt atataagaat
     6061 gcccgtccta ccctttcgct gctgactatc acttcgaacg taatgtatgg caagaagacc
     6121 ggtgccactc ctgacggacg cgccaaaggc attgcctttg ctcccggtgc caaccccatg
     6181 cacggacgtg ataaaaatgg tgcaatcgcc tcactgagtt ctgtagccaa gttgcgttat
     6241 cgcgactcac aggatggtat cagcaataca ttctcaatcg ttcccaaatc attgggagca
     6301 acacaagaag accgtatcga caatctggtg accatgatgg acggatattt tacaaaaggc
     6361 gcacaccacc tgaacgtaaa cgtgctgaac cgggaaatgt tgcaggatgc gatggaacat
     6421 cccgaaaagt atccgcaact gactatccgt gtctcaggat atgccgttaa tttcgtgaaa
     6481 ttgagccgcg aacatcagtt ggaagtaatc agccgcagtt ttcacgaaag aatgtaattg
     6541 aatgataaac gtacactcat acgagtcaat gggaacattc gacgggccgg gtctccggct
     6601 cgtcgttttc cttcaagggt gtaacttccg ttgcctctat tgtgccaatc cggacacaat
     6661 tgaagccaaa ggagggacag caaccgaccc tgaggaaata gttcgcatgg ccgtcagtca
     6721 gaaagctttc ttcggtaaaa agggaggtat caccttttcc ggtggagagc ctacttttca
     6781 agcaaaatcg cttatcccac tttttaaaag actaaaggaa gcaggaatcc atatttgcct
     6841 tgataccaat ggcgggctat ggaacaatga tgtagaggaa ctattggaat tgactgatct
     6901 ggttttatta gatatcaaag aatttaatcc ggaacatcat cagtctttaa ccggaagaag
     6961 caacgagcag accctgaaaa ccgcagcctg gcttgaaacc aatcataaac cattctggtt
     7021 gcgatacgta ttagtgcccg gctacagtga cttcgaagac gatatccggc agctgggaga
     7081 gcatcttgga acgtaccaga tgattcagcg tgtagaaata ttgccttacc acaccttggg
     7141 tgttcacaaa tatgaagcaa tgaacaaaga atatatgctg aaaggagtga aagagaatac
     7201 tccggagcag atagaaaagg ctgaaaaact attcaggcaa tatttccgga ccgtacaagt
     7261 gaattgactt atataagtgt cgaaattcgt attcgccaca gattacacga atttacacag
     7321 ataaagattc attggccatc aatagattaa gttcactctg cggtgaatta tgacgactgc
     7381 acttatttat aattttgtaa gtcacgatat aaaagtctcc ctgttcttgc cttaattcat
     7441 tacaatacaa ggcaagaaca gggagataat gtaaccggca tattttttgc caccctactt
     7501 taataagtga atcgcaatcc tgcctgcaag ttaaagttac aaggcctttc ttttcggatg
     7561 gtttgtactt tggagccatc atcaaagaaa tacgaaactc ccggttccac atataggccg
     7621 acatgatctg tcgcattgaa ctgcgctccc acggcaccgg ctacagaaaa ttgcaaaggc
     7681 ttcacattca ccttatcatc tgccaacttt ccataaacac acttttcaac cattcctccg
     7741 gcagatacat agagtgtaaa atatttcttt tccagaaaat tccagtttcc acgtacagga
     7801 atacctatat aatgcaattt ctgactctgc atcttggtat ccccctgccg tttgatatca
     7861 gaagacaaca acgtataagt caatcccgtc tctacagaga aacctttggg aagagactta
     7921 cgtacagaca gtccgaagct aaccggctga tgatgttcat aatccaccac ggcagttgta
     7981 ttggacttca ggtaaggaac cccttcttca aatataactt cctgatcggc aggaatactc
     8041 acagctccat tcatgatcgt catcaagtcg accctgttag tcatcggacg gggcgcaaaa
     8101 ttttcggaac catttgtcgg aagtccacct ccattaccga tacccactcc catcgaccat
     8161 ttaccaccac gtttagcaga agagtctccg ataggcaact gatacttgtc tttaccggac
     8221 ggtcgccgcg cttctttcct ctttggaggc tgcgccgtcg cactttcttt tttctcgatt
     8281 gcagcagttg cttcctgttg cggctcagtt ctcttttcct ccgtcactgc ctccggtcgc
     8341 ttctctgcca aggaggatac ctccggaaca atcaccggat cagtattctt tgccaaatag
     8401 cccgaaacag ggttgatact cgtcgttcct accggcttaa cgggttcgga tacagctacc
     8461 tgtacatccg gcaaggcagg ttccggcaat acatccgggt tgacagccag tgaaggagcc
     8521 gttgcataac ggatttcatc agctaccgga ctattcagaa aatacaaact gacagcagtc
     8581 gttaccacca ataccacagc tgccgcagca accgcccacc ggcgatacgg atatattcgt
     8641 ttttcggtta caggcatcag ttccctttcc agtcgttccc aaccggaagc aggcatcggc
     8701 tccgaataat cttcgagctt atccttgaat gctttaatcc atttttcgtc ttctttcatc
     8761 attctatttc atttttgaaa tccaaggttc acctcagtat ctgtaaatac atgtcaacca
     8821 ttggtcacca accattcttt cactttcttt gccaatacac tttttgcgcg aaaaagctgt
     8881 gaggcagaag atttttcatt aatccccaac atctgtgcga tttccttgtg cgacttatct
     8941 tcaaaggtgt ataaattgaa tacggtacga tatccggcgg ggagttcatt aataaattgc
     9001 atcagcactt tctgtggtat tgcttcaaca gccgaagcat ccggttcttc atacgtttcg
     9061 ggaacttcat ccagtgccgt ggtctggttc atcacgtcgt tctttcttaa gaactgtaaa
     9121 gccgtattca ccattacacg ctccatccat gctctcagag agccttcacc ccgccaggta
     9181 aacttgtcga aggagtcgaa aatcttcagg aaaccgtcgt gtaccaagtc ttgtgccata
     9241 tccctgtctc cggcataacg aagacagaca ccaagcatgc gccctgcgta ctgctcataa
     9301 agttctttgc gggcacgatt atctccctgc ctgcaacgtt ccgacagctc taattcattc
     9361 attctcctaa acacgtgttt accttataaa tgcagcaaag atagaaatac tgcacagaga
     9421 gaacaactct tttatcactt ttgtttcttt aacattttag gatgcaatat ttcatcactt
     9481 cctgcatttt ctcaatacaa taaagaataa atctcaatgg ataaatagga taaaaccaac
     9541 aagaaactta tgaagaaatt taatttaata acttttgccg tcatcctgat gttattgccc
     9601 attttacagt catgtctgga cgatgccaac aacgacgagt gggtcacttg tcctccgggt
     9661 ggaatattgg ccatcggcac aatgaagatt cccaatgcgg acactccaag ggactttttc
     9721 attgcattgg acaatggaga caatgtactt ccggcagata cggccgatat acgcaacagg
     9781 aaatacactg ttgcagaagg tcaaagagtc ttcgttggct atctgcagat gggagaagag
     9841 aaacccggat atgagaacgg taaaatattc acgatagaag atatattgac gaaagagatc
     9901 attccactga cggaagctac agcagacagc attggagacg accgtatcaa cgtcacagcg
     9961 catgcactta cgaaagatta tctgaccatc gaatatcaat atctgggcag catgaatgaa
    10021 aataaaaaac acatgctgaa cttggtacaa aacgaaataa caggtcccat aaaagatgac
    10081 ggatatatct atctggagtt ccggcataat gcctttaatg actcccccaa tcaattgggt
    10141 tcgagccttg tttctttcaa gctggatagt atagccgagc aattggcgac agccaaagga
    10201 ataaaactcc gtgtgaacac catttatgac aatatacagt atgtcacaat agatatcaac
    10261 gaagacaaaa acttaaaaat aaaatcattt cattctcaat aaaacaacaa gaaacaccta
    10321 cacaatcagg caaaacgagt aataattctg atacataaaa gaaataaggc ggcgatgttt
    10381 gtgaaaatat cgccgtcgtt tttatattat accagacact gaacggcctg cagggtaagc
    10441 atctccttgg gaaccgccgc ctgaatctcc tctttcaaaa cctgcagcag actggtgcgg
    10501 atgaagtctt tccgggtcac caggacaatc tgacgggtag gccgcgggat agcaaacgga
    10561 cggaccagtt ctttctgctc ttcgctcaat tgcatcactg ccagttcggg aataaacgta
    10621 atccccttac cactctccac catatgcata aaggtttcca tactacccag ccgatacgcc
    10681 atttggctga tcttaaccgc ttccatctga caaaaacgaa ccaactgatc gcggaagcaa
    10741 tgcccttcgt caagaagcca aagccgttcc cctgtcacat cggacgtacg aatcacatcg
    10801 tgcttgaaca acggttcctt ctttgagaca tagcccagga attgctcgta gaataaggtc
    10861 tcttccgtta atgcggcatc atccagcatg ctggcaatga tagcagcatc cacttcaccg
    10921 gtcagcagag ccttgcgaat gtcgggcgtc ttcagctcca tcacccgtat atcaagatcc
    10981 gggtatttct ccatcagttg cggaaagaaa cggggcagaa gataaggtgc aatcgtcggt
    11041 aacactgcca atcggaatgt acccgacagg gagtgctgtt cttcgctgat gatctccttg
    11101 acacagataa cttccgaaag aatcttacgg gcctgttcca gcactttctt accaatggca
    11161 gtagggcaaa ccggtgtcat gctacggtcg aacagtttca cccccaattc gtcttccagc
    11221 ttttggatca ttgcactcaa agtaggttgc gtcacccggc aatactcggc agctttagca
    11281 aaatgccgga actggtccac agccagaata tattccaatt gttgtatagt catcgttctc
    11341 tgatttatta aagatataga atctatcaat gcaaagatag aaattttcag tttgacacga
    11401 atcattttgt gccgtatctt tgttccagat aaaaagaaga aatatagtat taactcaaaa
    11461 aaaacaatat cattatgaag actttaaatt atacacattt ggaagaaaaa ggagctaaca
    11521 ccatcgtact gtcattacag caactgcttg ccgattttca gattcattat gcaaacctga
    11581 gaggatttca ctggaacatc aaaggacacg gtttcttcgt actgcacagc aagtttgaag
    11641 atttatataa tggagccgcc gaaaaggtgg acgaaatagc cgaacgtata ctgatgctgg
    11701 gaggaactcc cgccaataaa tacagtgact atctgaagat ggcgcagatc aaggaagtgg
    11761 acggagtgaa taaggccgac gacgctctga atcatattct cgaaacttac gggcatctga
    11821 ttgcggaaga acgtaaaatc ctgtctctcg cctcttcaca caacgacgaa gtaacagtgg
    11881 ccatgatgag cgactacctg aaagaacagg aaaagatggt ttggatgctg actgcataca
    11941 acggataaca gccgaaaggg tgtagccatc tgaccgaaaa ggtgtagcca tacaagcaaa
    12001 agggtgtagc catcccggcg ggatagctac accctttctg ttttattcga ttcagatgat
    12061 acttgtacgt ttggtaaatt caataatttc cggaatgtat ccgaatgcga gcccggtcac
    12121 tgtatccgca cacccataat agatggcaat ccgtccggtc tccgaatcat gaagcgctgc
    12181 gcatgggaaa cagacattag gcacatcacc catacattcg taatccttct gaggtgaaat
    12241 cagataaggc cccgaacgga attttacttt ccagggctga tcgatgtcaa gcagtgccga
    12301 accaaaacta tacacaaaac cgttgcagga agccaataca ccatgataga tcagtaacca
    12361 gccttccgag gtttcaatcg ggataggccc tgcaccgatc ttggtacact gccaggcact
    12421 gtcttcgaac ggagccggcg acataacatg acgatgacgt ccccaaaact ccatatcggg
    12481 agactcgcta tagaaaatat ctccaaaagg agtatgccca ttatcactcg ggcgactcaa
    12541 catcgcaaaa cgaccgttta tcttacgagg gaacaagact ccattccgat tgaaaggaat
    12601 aaaggcattc tccaactggt gaaaagtaac aaaatcatag gtgtaggcca caccgatagt
    12661 aggaccatga tagccattac accaggtcac atagtagcgg tcttcgataa agcaaacccg
    12721 tgggtcatat ccatagaccc aggttccaac ctcagcatca tcacattgaa actttaacgg
    12781 ttcttcgttg atatcccaat gaacagcatc cttgctgaat cccacatgca aacgcatgcg
    12841 acgattagta tcatcacaac ggaacacccc tgcatagcca tccttaaacg gaactacggc
    12901 actgttgaat atactgtttg aagtagggag caagtcgcgc ggaataatcg gattggccga
    12961 acaacgccac actacatctt tacatcctgc cggacgttct tcccaaggca tagccggcaa
    13021 agcagcacct gcaattttaa tttcttccat gattcgatta aattaatatt atgtatatat
    13081 cttgtttata ttgaaaatct ctttttattt cttctttccg tccggatatg tgaaaggtac
    13141 cagccaagtc acgataaaag ccggtatggt agcgataagt acccagataa agaaatcgcg
    13201 ataacccagc caatcgctca ggtatccgct catcattccg ggaagcatca cccccagatt
    13261 cataataccg gtagcaaaag cataatgtgc catctgatgt ttgccgggag ccacttgctg
    13321 catcataaag agcatcaatc cgacaaaacc aaacccgtaa cccaagtatt cagacacaat
    13381 ggccatacca ataatccata gatcggaagg ctggtaaagg gctaacagga aatataccaa
    13441 gaacggaata ttaaaagcgc aacataaaga aaacaaagtc ttccgaagtc cgaaagccga
    13501 aatgtaataa ccggccaaaa gcgaaccgag aataaaagct cccgctccga acgtaccata
    13561 taccagtccg atatcctgag tgctgagtcc caatccacca tccgcaaccg acgctttcag
    13621 gaacaacggt acaatcttga tggcatatcc ttcggcaaac cggtacaaaa tgataaagac
    13681 aatgtagaaa gcaatatgtt ttttttggaa aaaagagcgg atgacttccc aaagcatatt
    13741 caatgcgtca ctcatcgtat tcacttcacc ggaagcgcct cctcccgaag gcaaaatccg
    13801 gatgtggtaa agaccgatca gaatcataat acccgcacac atcaacatga caatcatcca
    13861 ggcatgtacc actccaaatt catccttcag catacctgcc agccaaacca agcctccgtt
    13921 ggcaagtatc ttggccagat tataaaaagc tccctgccaa ccgatatact tggcttgctg
    13981 ggtagcagtc agttcagtca ggtatactcc gtcacccgca atgtcatgag tcgcaccact
    14041 gagagcaatg atccccatca gagcgatggc ataacgaaaa aagtcgggca gcggcagcga
    14101 aagtgctacc aatgcaaatg ccagtccggt aatgatttcc gtagcgacaa caaagtactt
    14161 tttcgtttta aacatttcca gaaacggact ccataaaggc ttcaatgtcc agggaagcat
    14221 aatgagagaa gtccagaaag caatctgtgc attcgacact tccatatcgg aaaacataag
    14281 gacagaaacc atcgaaaggg ccacaaacgg caatcccata gcaaagtaaa cagtaggcac
    14341 ccaacataca gggcttatcg gctttttatt catcagttag ttttttataa taattccatc
    14401 ggttaacaat tccagtaagc aaagataggg gatattaaaa acataaccca agattacgac
    14461 aagaagttgc tttcattatt taataataca actcacccgg gaaaactact aacctctatc
    14521 accctttttt tattaaactt tattaataca atacacgcaa agaagcaccg aagactttca
    14581 tccccgatgc ctctcgcccc cttatctaca atctaaacac ctctattgct tcacatataa
    14641 atttatctca gcaaacccgg tataattatc cggagtcaga cagtttattc tgaattcctt
    14701 tacattcggg ataggtggtt cgatggccgc atattgcgga tcagcccctt taaaatttct
    14761 gaaagtcaag actctcgggt aagtaaccca ctcggtttca ccctctttcc gaaccttaat
    14821 ctcagcactt ctcaggttat aacccgatcc gtaggcactc tgtttagtga ccgaaaatcc
    14881 ggttaaggta acaggccggt ccagtaccgt attccaccaa cactctccgg cattagccac
    14941 tccccatgta aaccaagtag tatttatctc accgtcaata gccagatgtg caccatattt
    15001 agcatcatca tcggcataaa cattgctgca acttacactc cacgcacttc gatctacagc
    15061 ggaccaattc ccgggtttcg tataactggt ataaagcacg ctggtataaa tccggatata
    15121 aaccgtcttc atagatgtac tgacagcctg ttcgtccatg cccgtaactc ctttaagcgt
    15181 cacgggaagc acatatccgt caggattagt caacttttct atattcttca aaacgacctg
    15241 aaaagatgaa tcggccactg tctgtcccgt ttttaagaca acttcacttg tttcaatggt
    15301 ataattatct tggggcaaca acttacattt cgtcttattg gcagaattgt aagtatccac
    15361 tttcagcgta tctactccca aagcgacagt gacatcccgc gtaaccggct gtacggcaca
    15421 caattgtatt tcaaaatcag aacggtcggc agtagaggaa ttgctcacac aatccaccac
    15481 taccgcagca cccatttcgg cccccggtgc aactcccgtt ctgatatata tcttttgata
    15541 tttgtccatt tcatcatcat cgttgctgca cgaagccaac gatacaaagc ctgttatcag
    15601 gcagattaag gtcacaaaat tcaaatgtct attcatatct tatcttcttt ttacatagtt
    15661 attgcttatc aaaacgaaca tgctctttcc agacaagagt tcctcctgcc accaaatcgt
    15721 atccgtgtcc ggtacagtcg gcaaaggcat ttcctttacc ttcatccatt ttccaatagc
    15781 ctatcaggtt cggatcggcg ggtttcacgg caaaatacat gttggactga atttgcgtct
    15841 ggctgattgc gctcttccaa agacgcacct gggccatctg acaattgttg cggaagtaac
    15901 taccgctcga aaccatgttc atcttgtcga atctaaccgg gccacccttt gtctgcagag
    15961 tcacgtcgag cactccgttg atataaatcg acaataaccc ggaagaatta taaacgaagg
    16021 ccagatgata ccacttattc ttctcaaaca aagtcaccgt attgacctga cttccaagtg
    16081 tcttcacctg taatgaatta taagggatca tagcgtcacc gaaacggata taaacctcgt
    16141 ggtcgctgct gcccgaatta aatatagcct gattattaat atcgaatccg tccatctgta
    16201 cccaagcctc gagtgaccat tcattggttg tcactcccca caattcgtcc ttggcgggct
    16261 tcacggcatt ggtcgtattc ataaacggta cagactgtat cagcggctta tccagcaaaa
    16321 tgataaactt cgacgaaagc ccgattgtgg acaccggtcc ctgaatttct gtgagagata
    16381 ccggaatagc atacaattct ccgttttcgt ttgaataagg tttcactcta aactcactgg
    16441 ggattgcgct aacatcgcct gccgctatct ttatctcttt gtcataagta aaatactgct
    16501 cgggaaggac ttcgtacgaa gtttcattag cttcattgta ctctttaaga atagaaggat
    16561 ctaccgtcag gacagcagtc acattttcgg ttacaggctg tcccacacgt acggtcagag
    16621 tagttgttgt tacattttca ggatcaacgg taacctttgc cgaaccattc tcggatgctt
    16681 cattcaaata aatcgcattg tcgataacct ggtaatcggc atcgttgcat cctgccagga
    16741 tcatcggcag aacgaaacag gcaagcaaac attgttttat tgttattctt ttcataatca
    16801 aattctttaa agtcatttta cagcaggatt cattattctg attgcttcac gcaggtactt
    16861 atattcgatg tcgcccggat agtcatattc catgtgatag gtgcctactc cccccttccg
    16921 tacctgtttt ccgtcaatag tcggagtcca gcgtgccatg ccggcaagtg ctctcatttt
    16981 gtttccgtaa cgatctacat aatcacctcc tcctgtcgga gcataagatt cgaaattctc
    17041 cgtaacgatg tacatattag ccactttctc cggaggaagt attcctttaa agttggcaat
    17101 cgtaccagcc agacgtctgt caagattagc atcggaatta cccgcaaggt tagagtatgc
    17161 ctgcacaatg aaatagtcaa agtaaggccc ggtttccgga tgaatacttt gaggctcgcc
    17221 atcaatcaca agtaaccgtc ccgtacccga tttaggtccg attcttt
//
