LOCUS       gnlProkkaOMLMHIPO_18   13781 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMLMHIPO_18.
ACCESSION   gnlProkkaOMLMHIPO_18
VERSION     gnlProkkaOMLMHIPO_18
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 01:31:36
            Original ID  :: gnl|Prokka|OMLMHIPO_18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13781
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13781
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3430:3781]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3431..3781
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13781
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13781
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..94)
                     /locus_tag="ctg13_1"
                     /transl_table=11
                     /translation="MQHHYELTFISPEKDFWFFVKFGGTSSIVNK"
     CDS             276..1787
                     /locus_tag="ctg13_2"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1860..2927
                     /locus_tag="ctg13_3"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             2964..3248
                     /locus_tag="ctg13_4"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3431..3781)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_5"
                     /sec_met_domain="PqqD_RRE (E-value: 6.7e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.4e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(3879..5267)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5515..5910)
                     /locus_tag="ctg13_7"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVVKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5917..6690)
                     /locus_tag="ctg13_8"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6696..7223)
                     /locus_tag="ctg13_9"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7210..8451)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg13_10"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8461..9555)
                     /locus_tag="ctg13_11"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9560..10600)
                     /locus_tag="ctg13_12"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(10619..11653)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_13"
                     /sec_met_domain="PF04055 (E-value: 1.3e-17, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 atttattcac aatagaagaa gtaccaccaa atttgacgaa gaaccagaaa tctttttcag
       61 gagaaataaa agtaagttca taatggtgct gcattgaatt attttttggc ggagttattc
      121 taacacttaa tagttcaaaa acagatattt ctctgaccaa aagatagaac taatgatgaa
      181 ttaaaagttg caattatggt tttcttccca caacaaacgg gaaaagtcag aagaatcatg
      241 tacatttgta atccgaaaac taaaagaaca tcgcaatgaa aatatttcca agcagcagta
      301 tcaagaaatt ggacgcttat accattgaga acgaacctat tgcatcaatc gatctgatgg
      361 aacgtgcagc aaccgtatta acaaaagcca tcacagacag atggaatacg gaaacgccgg
      421 tcactatctt tgccggaccg gggaataatg gcggagacgc tctcgccgta gcccgcatga
      481 tggctgaaaa aggatataaa atcgaggtat ttctcttcaa cacgaaagga gaactttcac
      541 ccgactgcca gaccaataaa gaactggtag aaatgatgga agaagtaaaa ttccacgaaa
      601 tcagtaccca attcgtacct cccgtcctga cgcccgatca tctggtaatc gacggattat
      661 tcggttcagg cctgaacaaa ccgttgagcg gtggattcgc tgccgtagtg aaatacatca
      721 attcctcccc tgccatggta gtagccatcg acattccttc cggactaatg ggagaagaaa
      781 atacattcaa cgtaaaagct aatattatcc gcgccgacgt aactttcagt ctgcaactgc
      841 cgaagctcgc ctttcttttc gcagagaaca ctgaatttgt cggagaatgg gaagtgctgg
      901 atatccaatt aagcgaagac ggtattgaag agatggagac taactacgaa atgttggaaa
      961 tagaagaaat ccgttcactc atcaagccac gcaaacagtt tgcccacaag gggaacttcg
     1021 gccatgcact attgattgcc ggttcaaaag gaatggcagg agcctctgtt ctcgctgccc
     1081 gcgcctgcct ccgttcggga gtagggttgc tgactgttca tgcaccaatg tgcaacaacg
     1141 acatcttgca gacctccata cccgaagcaa tcgtagaaac cgacatcaac gaaacctgtt
     1201 ttgccgtacc taccgatacg gacgactatc aagcagtcgg catcggcccg ggactgggac
     1261 gaaacgagga aacggaagct gccttgttgg agcaactgga acactgccag actcctgttg
     1321 tagtggatgc cgacgctctt aatatcctcg ccaaccaccg ccataccctt acccacctgc
     1381 cgaagggttc catcctcacc ccgcatccga aagaactgga acgtctgacc ggcaaatgcc
     1441 aggactctta cgaacgtctg atgaaggctt gcgaactggc ccgtgccgcc catgtccaca
     1501 ttattttaaa aggagcctac tccgccatca tcacccccga aggtaaatgt ttcttcaacc
     1561 caaccggaaa tccgggaatg gcaaccggag gtagcggtga cgtactgacc ggagtaatcc
     1621 tggcgctgct tgcccaaggt tatcccaccg aagaagccgc taaaatcggc acttacattc
     1681 acggattggc gggcgatgtc gctcaaaaga agcaaggaat gatcggaatg atcgcaagcg
     1741 atattatcac ctgtctgccg acagcatggc gacttgtaag cgaataaaag ttaagaactt
     1801 acagtttttt caataacttc attaactttg ttttcaaaac cagttaaaaa gaaccgaata
     1861 tgaaaaagtt gattatagca gcaggactac ttatgacaac gtccgcctat gcacaaaccg
     1921 aagtactgac aggggttacc cgaggaaaag actatggagt ggtttacagt cttcccaaaa
     1981 cccaaataga acttgaaata aaagccaaca aagtcaacta tactccggga gaattcagca
     2041 aatatgctga tcgttacctg cgactgacca atgtctccgc cgaccctgaa gagtactggg
     2101 aactgactag cgtaaaagtg aaatccgtag gtgtgcccaa cagcgaaacg acgtatttcg
     2161 taaaattgaa ggataagaca gtagcaccgc tcatggaact gacagaggat ggcattgtga
     2221 aaacgatcaa tgttccttac agcaacagca gtgtaggcaa aaaagccgct cccgctccca
     2281 cagtcctcca aaagaaagca aatcctcgtg aattcctgac cgaagagatt ctgatggcta
     2341 gctctaccgc caagatggcc gaactggtgg ctaaagaaat ctataacatc cgcgaaagca
     2401 aaaatgcctt attgcgcgga caggctgaca atatgccttc agacggagca cagcttaaga
     2461 ttatgctcga caatctgaat gcacaggaag aagccatgac gcaaatgttc tccggcacct
     2521 gcaacaagga agagagaaca ttcactgtcc gccttacccc tgacaaggaa tttaacaatg
     2581 aagttgcttt ccgcttctcg aagaagttag gtgtagttgc caacaatgat ttggcaggaa
     2641 ctccgtttta tatcagtctg aaagacctga aatcggtcaa gataccacag gaagatggta
     2701 agaagaagaa agatttggat ggaatcgcct acaacgtacc cggacaagct atggttacat
     2761 tgaccgacgg caaaaagaaa ctttacgaag gtgaacttcc tattactcaa tttggtgtga
     2821 tagaatatct ggctccggtt ttgttcaaca agaattctac catcaaagtt tattttgatc
     2881 cgaatacggg aggattgctc aaagtggaca gagaagaagg gaaatagaaa aacgagaaag
     2941 tgaacttcta aaaaacaaag aatatggttg gtgaaggaca tgcattcgac atgatacgcc
     3001 gaataaaaga gggacgggaa gcttcccgcc tacgtcgtga acgtgctaac gacaagttga
     3061 agcatttaaa ccgtgcaaac gaaccttatc cactacccaa taccactccc gaagaaatgg
     3121 aacgtatcat ccacgactcg gagaaaaaga aagagaaaga cagcaattat tttgtttggg
     3181 gaacgcttat tatcatggga gtcctgatag caattgccgt catactttgg gctgtattta
     3241 tcaaataaat aataataaat tcaccacaga ggacacggag gacacagagg tttaatcttt
     3301 tttattcact atagagtaac acagagtctc acgtattgag aatcgtattt atcgctctgt
     3361 tttacttgcg gaaagagaga gaagaactct gtgtcctccg tgtcctctgt ggtgaaatat
     3421 aaattcctat ttatgcgact ggtatcacca gttttataaa tccatctttc tgcatttgag
     3481 aaagataagc cgatacacgc gactcgtagc cctcttcatt ttgaaaatgg tctgcgagtt
     3541 tttctataat ctcacgaaca ttgcgttttc catctatcag ttcccataca gccgtaccgt
     3601 gttcttccaa tttcacatga agttctttcg acattccttt cggcacaagg aagcgttgca
     3661 tccacggata tttaaaacgg ggaaaggaga gcacaattgt ctccccttcc ctttctgctg
     3721 taatatgttc actgcgacag ggaatgacct ctaacaggtt gattttctct ttggcagcca
     3781 tacttcttat tttttatttc agagtattca tactgatacc cttttgttta caccttgata
     3841 caaaattcct ttgttacttt aggtattgaa tttcccagtt acttttggat attcgcctct
     3901 tccagaccgt atcccttctt cttgttctct gccttcaaca tcaaagccac aatcagagca
     3961 agtacaccaa agagagcaaa aatagtcatc ggcaacgtgt agtcataagt ctgtgcaccg
     4021 tctactaccg gacctttgca ataagtattc aacacccatc cgatcaacaa aggaacaccc
     4081 atcaatcccc agttctgtac ccagaaaatc aatgcgtatg cggtacccaa ctgtttttcc
     4141 ggaataatct tcggaacaga cggccacata gctgaaggca ccaacgagaa ggcaaatccc
     4201 aatataatca tgatgatagt agcaaaccac catatattca gtataggcag agcaaacatc
     4261 gtatgcacaa aaataagcat cactgatccg attatcatca atgtggctcc cttaccgata
     4321 cggtcataaa gcgaaccgaa caacggagtc aggataatcg caccaatcgg caacaatccg
     4381 ggaatcgttc ccgccaactt cggatctacg ttatatttct gcaccatcaa gtcggcagca
     4441 tacttgataa aggggaatac agccgagtag aacaatacac atagtaatgc aatcaaccag
     4501 aatcctttat tggtaataat atacacaata tctttcatac ggaacggttc ttccggttcc
     4561 aatccctctg catccaaaga agcatccaac ttcttatcat agaaagtata aaggaaaaaa
     4621 gcaatcgtac ccacgcacaa cataatcaga caaaacaaaa tcggagcagg aatatttgta
     4681 tggaatgtgc cactctcatc cgtagatccg aaaaagtctg ccaaaggaac tgtcaatacc
     4741 atcgccagag ttgttccgat acgtgccgta gccatttcaa gtcccatagc caatgccatt
     4801 tccttgccct tgaaccattt cactataatc ttggaaacag tgataccagc aatctccaca
     4861 cctacaccaa agatagcata tcccaatgca gccaacgtca cctgtgtttt aaatccaaag
     4921 agcatggcac cttccggaaa agtagtagaa atcgcatagt atttcaatcc acaaccaaac
     4981 accatcaata agcaagctcc cattccggtg aaacgaactc ccattttgtc caaaatgata
     5041 ccaccgaaga tcagcatcaa caagaatacg ttaaaccaac cgtaagcgct tgtgaagaat
     5101 ccataatcaa gactatccca taatagttct ttctcaagca tgggttttag aggagacatt
     5161 acgtcggtga ggaaatagcc gcatagcata gtaaatgcga ccaatgctag aacactccat
     5221 cggagtacgg cggagtcatt caatttctgt ttcaaatgtt ctgtcattgt tatatttaaa
     5281 aaagtagtta ataatcttat acagccaaca aaggtagtta aatctcgttt gtttctatca
     5341 caaagagatt gtttttacaa gaaaaagtta agtgcggatt acactgacca cgcggaacat
     5401 tgaaaatccg tgtaatctgc gtaatccgca cttaaatatc aaagaaatgc agcatccgtc
     5461 tgcaccttcc cattaatggt tttaccccaa agtcttacct gacgacggag tgaattactc
     5521 tgctgcagga gcaggagttt cagtagccgg tgccggagtt tctgtagcag gtgcattggt
     5581 agcaggagct tcagtttgcg gcgcagccgt acctgcgggt aagttatacg ggttagtctg
     5641 ttgttctttc tgtgcctgtt ccaacactgc atctttaaca actgcagaac gaggaactac
     5701 ataagcagta gcaatgctca ttacaaccat aaagatggcc aggccccatg ttgctttttc
     5761 cagaaagtct gtagtcttgc gtacgcccat gatggcgtta gatgaagaga aaccagaagc
     5821 aagtccgcct ccttttgagt tctgaatcag cacgatgaaa cacatcaaca aggctgcaat
     5881 aaccattaag ataacgaata ataagtacat ttttagttat tttgaattag cgttaataat
     5941 caatttctcc aaaaatctga tttggtctgc aaagtaagca tttttttttg gatatttcaa
     6001 gcttaatttt ttaattattt caagagcttt tgaatatcgt tgctgtttaa catagatttt
     6061 tgccaaagtt tccgtaaaac agctgtcatc ttcctcttct tccttcatcg tttcttcttc
     6121 ggtaagttcg tccgaagagg ttggcgaaga tggcatttct tctcttaaag gtttcatgca
     6181 gaggggagag tcgctctcgc tcttttctat aaagtcgtca atcagttcga agcctttgag
     6241 tttgggcgtt tcttcagccg gctgttccgt ggccggagtc tcctccaaaa ggaaagaggt
     6301 gtaatccatc gaatagtcga aactggtccg ggcagtcacc tcttcgggta ctgtggacaa
     6361 gaaagcgtcg atcaatgcta atgtgcggtc tacggacggt tcgtctttca gcacctccgt
     6421 gagaggtact ccctttttcc gtgcctgcac atcatagcgg tcaccttcaa tcaaccggaa
     6481 caactgccgt ctgtctgcaa tgtaaagaac tgctttccgc agttctccac cgaaactaat
     6541 atcatggaga atatacagat tcttcagata cagcagacga agtgactgaa aatacggata
     6601 cctcgcaaga agattgcgca gttcgtacaa agtatcccta ttcagcgtct cgggatgctg
     6661 aatccattgt tgaaagttaa cagaagtcat ttatattacc agtttgctac agttgcatta
     6721 aaaatttggt cggtgatctc tttagacatt tcagcaatca atccgtcctg tacggcagtc
     6781 aacaactggg tagagtcgta agtacggaac gcagaaaact gttgttcaaa gtcttcggca
     6841 tgattggtgt tgttgacaaa acgcacattg acggtgatag tcaacttcgt ctccgaagaa
     6901 taaccgtcgg cagatactgc ctgattgtac tgattgtaac ctgtgatttc tccgtcaatc
     6961 tgcaagtcgg cattttgact cggcttgagc agttgcagac gggtctgccg gatgaagata
     7021 tctttcaggt cctcattaaa cttggttgcc aacggagcat acacatactc cgacttgatc
     7081 gggaagtcgg ctatcgaaat ggtctttacc ttatcataat tgatagacga tccgttaaac
     7141 ttataggaaa cagtgcacgc aatgactacc aacggcaagc cgaacagtaa caaagggcgt
     7201 attattttct taatccaatt catattcttt tatttttcta taaagtgtac gctcggaaat
     7261 attcaagtcc ttggccgcac tcttccgctt tccgtgatgc ctttcaagtg ctttgcgtat
     7321 catttctttt tccacttcgt ccagtgacaa aggaggttct tctacatatt cttccgtgtc
     7381 ttgtatgtcg tcatcatcct tgcaaaccgc aggctgcatg gtatgaatga tcgcaggtac
     7441 cgaaggctgg tgtgtcgtca ctaccggagt agtaaccacc gttcccactt gtcctacctg
     7501 ccccacctgt ccggcacgtt ccgccatcag gttgtgcacc atcttcttca gctccgccac
     7561 ttcctggcgc atatcgaaca gaacagaata aagaatctcc cgttcgctct caaagccttt
     7621 actctcacgc gttcccatca gcgcgggaag acgttgcgta ttttgtgcgg gaagataatt
     7681 ctgcaagata gcagcagaga tctccctgtt ggtttcaatg atagatattt gctcggtgat
     7741 gttcttcaac tgacgaacgt tgccgggcca cgggtaagcc aataactctt tcttcgcatc
     7801 ctccgtcaac tggatagcag gcatccggta tttctctgca aagtctgcgg aaaacttacg
     7861 gaacaacaaa agtacatcgt caccacgttc acgcaaaggc ggtatttgga taggcaccgt
     7921 attcaaccgg taatataaat cttcacggaa acgtccttct gcaatcgctt gtgtcagatt
     7981 gacattggta gctgccacaa tacgaacatc cgtcttttgc actttggacg aacctacttt
     8041 tataaactcg ccactctcca acacacggag caaacgcgcc tgggtaggca tcggcaactc
     8101 ccctacttca tcaaggaaaa tagtaccacc gtcggcttcg ccaaagtacc ctttccgttc
     8161 gccaatcgca ccggtaaacg cacccttctc atgcccgaac agttcggaat caatcgtgcc
     8221 ctccggaata gcaccacagt tgacagcaat atactgtccg tgcttcctcc ggctatattg
     8281 atgaataatc tgcggaaaac tttcttttcc gactccactt tctccggtaa tcagcacaga
     8341 caaatcggta ggagctacct gaatggcaac atctatggcg cgcgacaatg cttcagtatt
     8401 tccaataata ccgaaacgct gtttcacttg ttgtatctct gctctcgtca tcactcgttt
     8461 ttaatcttcg tctactgtat ccagcttcag tttatcacta tcgtcacgtt tctcgtaata
     8521 ctgtttacgc aacggattgg cacgagccac tttttcccgc tgacgattac ggaacacatc
     8581 gatggcaaca tagattgcct gacggaaaga atcttcacaa gccaatccct tgcctgcaat
     8641 atcgtatgcc gttccatgag ccggagaagt acgtactacc ggcaggcctg ccgtatagtt
     8701 caccccgtct tccatagcca aggccttgaa cggagccagc ccctgatcgt gatacatcgc
     8761 caggataccg tcaaaatgag tataattgcc tgaacccata aagccgtcgg ccgcataagg
     8821 accgtagcaa aggattcctt tctcttccat ttctttcatg gcagggataa tcacttcctg
     8881 ctcttccatt cccaacaaac caccgtctcc ggcatgagga ttgagagaga gcaccgcaat
     8941 acgcggagcg ccgataccga aatcctgttt caggcaacga tggaatatca tcagtttctc
     9001 ctgaatcagt tctttggtaa tcgtagtcgc gatctctctg acagggatat gtgtcgtcac
     9061 caaagccacc cggaagtcat tcttcatcaa aatcatcaat gacttatcac cattgcccag
     9121 acgttcttcg atatattccg tatgtccggg gaaagagaac tcttccgact gaatcgtatg
     9181 tttgttgatc ggagctgtta cgataacgtc tatcaaccct tcgcgatatt cttcaatggc
     9241 acgttccaaa gcccccagcg cagctttacc ggcttcgggg tcgggtttgg aaaattccac
     9301 tttcacctca tcatccgtac agttcaccac actcaaacgg ttgtaccccg cttcggtagc
     9361 agagttgaca atgctgaaat tggcctgtat atccagcgct ttgcgatgat aagccgctac
     9421 tttcggtgag ccataaatga tcggagtaca tagttccaac attgtagggt cggaaaatgt
     9481 cttaagaatc acctcatagc ccaccccgtt aatatctcct tgggtgatac ctatccttat
     9541 cttgttatct tccatgtttt tatttattag tttgttccgc ttccttagat gcttctccca
     9601 atggaatctg cttctgctga acttcattcg gaagtttcag tgtatacaga gatgcttcca
     9661 tctggcgtac caggttgcgt ttcattttat caggtgaata aacaaatatt tctgctgtaa
     9721 taattcgttg gtttttctcg tccagacgag tatgagacac atacggacca cccataaagt
     9781 cgcccttcat acgccacagg ccacgtgctt ccattgtgta gctgttctgc acattgatcg
     9841 gacggacatc ggtcagcaaa ctatcggtcg acatataaac gccctccttg aatccgggaa
     9901 tattggcttt catcacggag tcacgtttgt gcacaaaata ttctttggta aacgtatcct
     9961 tgtcagtgta cggataagag tacatcacaa agttacggtc ggcagtacct gtgttggtag
    10021 aagcccagaa gaaatcatcc ccggtctttg aattagccag ttcggcatcc acccagatgt
    10081 cgcatccgaa caaactgtcc actttctgcg aaatgaaatt actgtgtttc ccttctagaa
    10141 acgtaatctg acggttcatt tccgcacggg taaagaagtc gacaatcgtc tttttgttct
    10201 cttccacaaa cttctcgaac tcttcttcgt tcggagcctg gatagtcaat atcatctgcg
    10261 gattggcata cacgtccttc gcatatttga acgaggcttt cgtatatata tcctgtatat
    10321 ctacaataat aatgttacgt atcaacttca gcgtagaatc ataatctttc ggcgaagtat
    10381 acataatccg gaaagaaggt tccgactgcg gcaaaccggg catatcagca tcgagcgcat
    10441 catgtaaagc ccttccggca gcacgatccc aaacaccgtg atctactaca accaaaagct
    10501 cgtaagcacg accactagag gtgtgatttc ctttcagacc acaagatgca acgacaaagg
    10561 ctaccaaagc gatgcataaa ataaaagagt actttttcat gatgttcggt tttatatatt
    10621 aactttcatt atttttctcc tgtttcgctg tcgacagcat accgcaagcg gcaaaaatat
    10681 cttcgcccct ggatgaacgg atagtggtga aaagtccgtg tgacgtcaga taatcacgaa
    10741 aacgggtcat cgtatccata tccgccccct cgaggtctac ccccggtatg gcatgaaaac
    10801 gaatcagatt caccctgcaa tccagcccgc gaagaagttt cagcaactct ttggcataga
    10861 cctgcgaatc attgagccct ttaaaaacaa tatattcaaa cgaaagtcga cgttgtttac
    10921 taaaatcata gttttttaac agttccacca tttcggtgat tgaaaacgcc ttttccgccg
    10981 gcattaattc agcacgctga acggtcagcg gagagtgaag gctgatggca aggtggcagt
    11041 cattttcttc aataaaacgc tgcaatcctt tccgtagccc gactgtagaa agcgtgatac
    11101 gcttcggact ccatgcgtaa ccgtaggtag cggtcagtag ttccaatgcc ttcaatacct
    11161 catccaggtt atcgagcggc tcgcccattc ccatcattac gacattagtc agtttgtccc
    11221 gttccggcag cgaatgaatc tggtttatga tctggctggc ggtcaggtta gccgtatacc
    11281 cctgtttacc ggtcatacag aacttacagt tcatcttgca acctacttgt gacgacacgc
    11341 acaacgttgc ccggtcatca tccggtatat aaaccgactc tacaaaatgg ttctcaccca
    11401 ctttataaag atacttcacc gtaccatcta cagagcgcat ttcatctacc ggagcttccg
    11461 ctcccacctc atagttctgc ttgagcaact cccggtgttt caatgacaaa ttagtcatat
    11521 catcaatcga ggctaccttc ttttcgtaaa gccaggatgc aatctgcttg gcagcaaagc
    11581 cgggcatacc cagtcttttt gtcaatgatt gaagctctac aagagtcatt cctaaaaggg
    11641 gatatttaga cattcttctt tctgttgata gtttatatct gcaaatgtaa ggaaataaag
    11701 tcgatttccg tatagcagga atgtaaaagt taacaaaaaa gggaagtatg cctccgttat
    11761 gattcaacca cgctgatata ttgaagtagc ttttgcgcca tttcagaatc ctcgccattc
    11821 tttttcactt catgaccgta cgcctcacgg aaacaagcca gcgcctcttc ccgttcatta
    11881 caaaagctgt gcaaaacccc taagttctga caagccagaa tcgtatcttc ttcctcccat
    11941 cccaaatact tctttcgcag ttcgaactct ctgaagaaag cctctttcgc cattggataa
    12001 ttctccaact tcacataagc ctgtgctttg taataatata ccagacagga agcattaggg
    12061 tcagtatcat cgtgaaaatc caaagacgtt gcaatacgaa tcacgttatc atagtcttta
    12121 ttcatgtaat actgctgcat aatatcacat ctcaatgcct cgtagcggac agtcagttcc
    12181 gccagacgcg gtttttcgct gaaatacatt tcatgcagaa gagactcacg gaagaataaa
    12241 gtagatgcct gctcatcgcc acgttcattc atcatccgtt tgaattccct gcacagataa
    12301 tacaactgtt tatgacaagc gacgatctgt tttttactat ctatctgtat agcaatgtcc
    12361 aacgcctgat tcatcagcat ccatgcttca tcgtatcgtt tgatataata aagacattta
    12421 ccctgcatac gcaaacattt agccactcca ccggacagtc tgccattcaa cgactcatgc
    12481 atttcagcta ctttccggaa tttctcggca gcactctctt cctcatcctt atagtaatca
    12541 caataagcca gatattcgga aagttcaatg acttctgcct gactcttctc gtcagcagaa
    12601 gccgcatgat aatcaagcgc cctattcaga tagatcactg cttcattgta ttgctcattg
    12661 tagtaatatg ccagagctag atttcggcag gtgttggcaa tctccagttc cggagtaggt
    12721 acaatgtttt cctgcatcac caatgctttc aagaaacagt cgcatgccgt ttcgtactct
    12781 tcattacggg catagcggca tccctcattc atcttcaata ccgacttggc aatgagtggc
    12841 atggcagcac cttccatact cttctcactc acagcagctg ccgccttcgt cagatggaaa
    12901 gaactgctca agaaagtagc catatcatta gcaatgacag gaattaaaaa agaatcgatc
    12961 tcatcaaagt ccaattcggc atagacttca ggcgtaactt caggattgtc gttcatgatc
    13021 gccttccagc tatcttccaa cagagaacga ttcgtgcgat acaaaatctc gaaaatctcc
    13081 acatcacaaa tccaatcctt caatatatcc cattcttgca tcttatagca ttgataggta
    13141 atctccactt tatagcgata cgaatcatgg tagcagaact gtttcatgcg atagttataa
    13201 tcggcaaaag tcaacggatg ggaaaggacc tcttcctcat ccagcaaagc ggaaataatt
    13261 tcatggcgac tatcatctat acattcgtca tcttgagcga aatagcgttc gattgcctct
    13321 accatttgtg tgtcaccaat gcaatatcgt cctcctttgt tggtaagcca gctgctcatt
    13381 tccactctca actgcgacca aagtatctga ttaatgtctg ccatgctctt cacttcatct
    13441 tcggtaaatc cttctaaagt aagtgaaagc atcagaagcg ttcttccaat ctcttcgaaa
    13501 ccataatcag ccgacaaacg ccgtagcaca ctgtcataga attgcccaac ctcattgagc
    13561 cggcaatatc cactcatata ttcattgaga gcatcgtact gaccgaacga aaccagctcg
    13621 ttgagcaata cacttaaaca gcgcggttgt ttagccagca cccacgaagc aagaatatct
    13681 tcctgttgtg cagacaaagc cttggagtaa gtagacaaat attgctttga gaacgacttg
    13741 gcatccgcct gtgaaaaacc attcaactgg aaatgggcgt a
//
