LOCUS       c00002_gnlPro..        14363 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KLOCNCOL_2.
ACCESSION   c00002_gnlPro..
VERSION     c00002_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:54:23
            Original ID  :: gnl|Prokka|KLOCNCOL_2
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14363
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14363
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[373:4363](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(374..4363)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14363
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14363
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(374..4363)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_1"
                     /sec_met_domain="HGD-D (E-value: 1e-63, bitscore: 207.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 6.8e-37, bitscore:
                     118.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VANALQDYEPKTDVAIELGGEDAKIIYFNNGIEQRMNGVCAGGTG
                     SFIDQMASLLQTDATGLNEYARDYDTLYPIAARCGVFAKSDIQPLINEGATKENLAASI
                     FQAVVNQTISGLACGKPIKGYVAFLGGPLHFMPELKNAFIRTLNLDEEHIIDPPYSHLF
                     AAKGAALNAKEECSFTLDDLLKEFESDIQLAVEVERMEPLFKDEKEYDEFIEEHNQFKV
                     KKADLATYSGKCYLGIDAGSTTTKLALVGEDGSLLYRFYDNNNGSPLNTTIRAMKELKE
                     LLPPAAKISGSCSTGYGEALIKAALQLDHGEVETMAHYYAAAFFEPDVDCILDIGGQDM
                     KCIKIRNHAVDNVLLNEACSSGCGSFIETFAKSLNYSVADFAKVALFAPSPIDLGSRCT
                     VFMNSKVKQAQKEGASVGDISAGLAYSVIRNALLKVIKLTDPKQLGKKIVVQGGTFYND
                     AVLRSFERISGCHAVRPDIAGIMGAFGAALIAREREEETGDTQMLSIDEIINLEYSTSM
                     SRCQGCNNHCILTINKFNNDRQFISGNRCERGLGLEKNHEHVPNLYEYKYKRIFGYKAL
                     KPDEAKRGVIGIPRVLNMYENYPFWYTFFTNLSFRVLLSPKSSRKIYELGIESIPSESE
                     CYPAKIAHGHVMWLLKKGINTIFYPCVPYEEDQMEGANNHYNCPIVTSYAENIKNNMEE
                     LRDPNVLFMNPFLALDNADALKVRLYDELSKHFDVTKEEIDHAVDEAYKEAAQVRKDVQ
                     AKGEETLAYLAETGKMGIVLCGRPYHIDPEINHGIPELINSFGIAVLSEDSICHLGHVE
                     RPLIVSDQWMYHSRLYAAANYAKKNKQLEVIQLNSFGCGLDAVTTDQVNDIMTNSGRIY
                     TVLKIDEVNNLGAARIRIRSLIAAVKIRNRKHIEPHPVPANIEKVEFTKEMKKDYTILI
                     PQMSPIHFDLLTPAFRHCGYNVEILPEMGKQAVDTGLKYVNNDACYPSLIVVGQIMTAL
                     TSGKYDLNKTAVIISQTGGGCRATNYIGFIRRALAKNGYGQIPVISLSVQGIEKNEGFK
                     FTPALLVRALQGVIYGDLFMRVLYRVRPYEKVKGSANHLHEVWKKRCIKSLEKARYGEF
                     KKNIRGIIRDFDRLPITDEKKPRVGIVGEILVKFLPDANNHLVELLEEEGAEAVMPDLL
                     DFMFYSFYNSNFKAEYLGKSTKAAKLCNMAISALEAYRGFLRKELERSDRFTAPPHIEE
                     LAEYAKPIVSLGNQTGEGWFLTGEMVELIKQGAPNIVCTQPFACLPNHVVGKGVIKELR
                     RKYPESNIVAIDYDPGASEVNQVNRIKLMLATAEKKLKSDLPQAR"
     CDS             5038..5409
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_2"
                     /sec_met_domain="LysM (E-value: 3.8e-14, bitscore: 44.0,
                     seeds: 155, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKVYVNICDTKKCPGPVYAVKTGDTLYSIAQRHHCRVRTLLDL
                     NPFVDIYNLQPGEEICVPDCRGQGKVDFRPYVVKEGDTLKIILKNVSMTFEELAKVNRI
                     LYNLTVPAGTILLVPAKKE"
     CDS             5605..6543
                     /locus_tag="ctg2_3"
                     /transl_table=11
                     /translation="MIRIFKTTDSGIRKVAVAEEGCWIALTNPTAEELSTTADQFNIDV
                     DDLKSPLDEEERSRIQVEENYTLIILDIPTIEERKGREYFYTIPFGIIFTDKYIFTVCL
                     VDSPVLTVFMDGRVRDFYTYKRTRFIYQMLYRNATMFLQYLKIIDKKSDEVEKKLHISQ
                     RNQELIEMLDLEKSLVYFTTSLRGNEVVLEKLMRNTSIPRYEDDEELLEDVIIENKQAI
                     EMAKIYSDILSGTMDAFASVISNNLNIAMKFLSVITIVLTVPTIVTSALGMNVAGIPFA
                     NNPYGFWIVVGISLLLTLIAGAIIAKNKHFK"
     CDS             6690..7505
                     /locus_tag="ctg2_4"
                     /transl_table=11
                     /translation="MNWLDKLERKFGRYAIRNLPLYIVMLYAIGAVLNILTKGSYYYYV
                     ALNPYMILHGQIWRLLGFLIVPPNASLIFIIFVLMFYYSIGESLVQVWGAFRFNMYILI
                     GVLATIVASFIVYFIYPSTMIFMDTFYLNLSMFLAYATIFPEMRVYLYGILPLKVKWMA
                     WFDVALLVWQFVVGGLGARIAIVVSLLNFLLFYFSSRNYKKVSPKEIHRKRAYRKASSV
                     ASNKPYRHKCAVCGKTELDDPNLEFRYCSKCNGNYEYCNEHLFTHTHVK"
     CDS             7611..7931
                     /locus_tag="ctg2_5"
                     /transl_table=11
                     /translation="LLTISEHIMIGETISHDAKAILRGVRHPFIWKKGLWYGITTSCGK
                     DVIMYILSSREMRQKFYQNNDLKLLGLAGSMKEAYEIVLKLVQMGYNSDCIYEMNDYLE
                     KF"
     CDS             7947..8876
                     /locus_tag="ctg2_6"
                     /transl_table=11
                     /translation="VLYVLLLLLKILGILLLLFIGLVLLVLLTPIRYSFELEKEEQKEP
                     KFMVRVTWLFWLFYFKTSYIEKVFNYRIRILGYQIAGNQPEFLEKQKERQKKKSQKEKA
                     KEERKTAETLAEGKSRSIDSVSKQKAEKAVPKEKSSDVSEGREKTKEKDSGDDKNSKDK
                     KKNKEKKQKDGKKPKKESSLKKIKSKIKSLKETKVNLDKMPWREWLELGKDVLIRFLKH
                     ALPGKLEGNIAFGTGNPEYTGYITGIAAVFYSKYGEHFSLYPDFERKMFEAKCRGRGRI
                     RLGYMLVLAVSILKEKSVRTMIKNIILG"
     CDS             8892..9332
                     /locus_tag="ctg2_7"
                     /transl_table=11
                     /translation="MDKQNFDTTVNSLFSGMDHVLSSKTVVGEPQVIGDTIILPLVDIS
                     FGMGAGAFNKEKGSSAGGGIGGKMSPSAILVIHNGQTKLVNIRDQDAVTKVLDMVPDAV
                     NKVVSIIKGEDAEDKVDPEVESAVNKAAQAEASVVDVDGAGI"
     CDS             10173..10529
                     /locus_tag="ctg2_8"
                     /transl_table=11
                     /translation="MKGQMHTDLGQVIIDEEVIATYAGINAIECFGIVGMASVNMKDGF
                     AQLLKRDNVSKGVHIKINDNKIYIDFHIIVVYGVSIATVTENLIQNVKYRVEKFTGMSV
                     EKINIYVEGVRIVD"
     CDS             10698..12197
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_9"
                     /sec_met_domain="Dak2 (E-value: 3.2e-40, bitscore: 129.2,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNSHTIDAKTFQKLFLAGANRINSRKDYINELNVFPVPDGDTGTN
                     MSLTILAAAKEVGAVAEPTMATICKAISNGSLRGARGNSGVILSQLFRGFTKAVSKADS
                     LGKDEITAGFTRAVETAYKAVMKPKEGTILTVAKGMADKAEELVDEDMDVIAFCEAIVA
                     YGYEVLSKTPDMLPVLKEAGVVDSGGQGLMEVLQGIVDALTGKVTDIEVPAEAASMSSA
                     VISAPKADISTADIKFGYCTEFIILLDKPLTKEDEKGLKKFFLSIGDSLVLVADEEICK
                     VHVHTNHPGEAFEKALTFGALSNMKIDNMRLEHQEKLIKDAENEAARQRQQEAEEEKLA
                     AKEAAAEKPAKEVGFIAVSVGEGLTDIFKGLGVDYLIEGGQTMNPSTEDMLNAIEQVNA
                     KNIFILPNNKNIILAAEQARDLTEDKKIIVLPTKTIPQGISAMIGYMPEAGVDENEENM
                     KEAYQDIASGQVTYAVRDTVIDGKEIHNGDIMGINDDGSLQ"
ORIGIN
        1 cacgcgttat gataaattag catccacttt tgcagcattt atatgcatcg cctcaatatt
       61 aatttggtta aaatgaacaa cttaaaatgt ttttcaaaca cgctctagag cgtatttgaa
      121 aaatcattcc tacaatctgc acgccccaat ttgcggtata ttttgctttc attcagttgc
      181 cgtagcccgc tacgccgccc tcattcagga aaatcttcca catcccaagc acagccctct
      241 gagaatgaaa gaatccttat ttgtggcctc ggagcaagtg ttggatacga gcgagtagag
      301 cgagtattca acacgccgcg actaaagtca caaataagga ttctttcatt ctcagagggc
      361 gtttgtttgg cgtctatctt gcctgcggca aatcagattt caacttcttc tccgctgttg
      421 ccagcatcaa tttaattcgg tttacctggt ttacttcgct tgctcctgga tcgtagtcaa
      481 ttgcgacgat attagattcc ggatacttac ggcgcagttc cttgataaca cccttaccta
      541 caacgtggtt tggcaggcag gcaaatggct gtgtacatac aatgtttggg gcaccctgtt
      601 tgataagttc aaccatttca ccagttaaga accatccctc accggtctgg ttaccgaggg
      661 atacgattgg ttttgcgtac tcggcaagtt cctcaatgtg aggtggtgca gtgaaacgat
      721 cgcttctttc taattctttt cgaaggaagc ctcggtaagc ttcgagtgcg gagattgcca
      781 tattacataa cttagcagct tttgtagatt ttccgagata ttctgcttta aagttactgt
      841 tgtagaagga gtagaacata aagtctaata aatctggcat tactgcctct gccccctctt
      901 cctctaaaag ttctaccaga tggttgtttg cgtctggaag gaattttacg aggatttctc
      961 caacgatacc aacacgaggt ttcttctcat ctgtgattgg taatctgtca aagtcgcgga
     1021 taatgccgcg gatatttttc ttaaattctc catatcgtgc tttctcaaga gatttaatac
     1081 aacgcttttt ccatacttca tgtaaatgat ttgcagaacc ttttactttt tcgtatgggc
     1141 ggacgcggta gagaacacgc ataaataaat ctccgtaaat aactccctga agagcacgaa
     1201 ctaaaagtgc cggagtgaat ttaaaacctt cattcttctc aattccctgt acgcttaaac
     1261 tgataactgg aatctgaccg taaccgttct tagctaatgc acggcggatg aatccgatat
     1321 agtttgtcgc acgacagcca ccaccagtct gggagatgat aacggctgtt ttgttcagat
     1381 cgtatttgcc ggaagttaag gcagtcataa tctgtccaac aacgataaga gatggatagc
     1441 aggcatcgtt atttacatat tttaatccag tatctactgc ctgtttcccc atttccggca
     1501 aaatctctac gttatagcca cagtgacgga aggcaggggt gagcaggtcg aaatgaattg
     1561 gggacatctg aggaatcaga atggtgtagt cctttttcat ttcttttgta aattctactt
     1621 tttcgatatt tgccggaacc ggatgtggct caatgtgctt acggtttctg atctttacgg
     1681 cagcaatcag agaacggata cggattctgg cagcacctaa gttatttacc tcatcaatct
     1741 taaggacggt ataaatacgt ccggaattcg tcataatatc atttacctgg tcggtagtta
     1801 ccgcatcaag accacagcca aaggagttaa gctgaatgac ttctaactgc ttgttcttct
     1861 ttgcgtagtt tgcggcagcg tacagacggg aatgatacat ccactggtca gaaacgatta
     1921 atggacgctc aacatgacct aagtgacaga tggaatcttc acttaatacg gcgatgccaa
     1981 aagagttaat cagttcagga ataccgtggt taatctctgg gtcgatatgg taagggcgac
     2041 cacaaagaac aatacccatc tttccagttt ctgcgagata agcaagtgtt tcttcgccct
     2101 ttgcctgtac atcttttctt acctgtgcag cttctttata agcttcatct acggcatggt
     2161 caatctcttc ttttgtcaca tcgaaatgtt tagataactc gtcataaaga cgtaccttca
     2221 aggcatctgc attatcgagt gctaagaatg ggttcataaa aaggacattc ggatcacgga
     2281 gctcttccat gttgttttta atattttctg cataagatgt tacgatcggg cagttgtaat
     2341 ggttgttggc accttccatc tggtcttcct cataaggaac acaaggatag aaaatggtgt
     2401 tgataccctt ctttaaaagc cacattacat gtccgtgtgc aatctttgca ggatagcatt
     2461 cggattcact tggaatggac tcaataccaa gctcgtaaat ctttcgggaa gactttggag
     2521 aaagcaatac ccggaaagaa aggtttgtaa agaatgtata ccagaatgga tagttctcat
     2581 acatattcag tactcgtgga ataccgataa caccacgttt tgcctcgtct ggttttaatg
     2641 ctttatatcc aaaaattcgt ttatatttat attcgtaaag gtttggtaca tgctcatgat
     2701 tcttttcaag gccaagacca cgttcacaac ggttaccaga aataaactga cggtcgttgt
     2761 taaacttatt aatggtaagg atacagtggt tgttacatcc ctgacagcgg ctcatggaag
     2821 tgctgtattc caagttgata atctcgtcga tggagagcat ctgtgtatct ccagtttctt
     2881 cctcacgctc tcttgcaatt aaggctgcac cgaaagcacc catgataccg gcaatatctg
     2941 gacgaacggc gtgacagccg gaaatacgtt caaagcttcg aagtaccgca tcattataga
     3001 atgtaccacc ctgaacaacg atttttttac caagctgttt ggggtcggtt aacttaataa
     3061 cttttaataa ggcattacgg ataacggaat aagcaaggcc agcagaaata tcaccaacgc
     3121 ttgcgccttc tttttgtgcc tgttttactt tggagttcat aaatacagtg cagcgggaac
     3181 ctaagtcgat tggagatggg gcaaacagcg caacctttgc aaaatcagct acagaatagt
     3241 tcagagattt tgcgaaagtt tcgatgaaag aaccacatcc agaagaacag gcctcattta
     3301 aaagtacgtt atctacagcg tggttacgaa tcttgataca tttcatatct tgtccgccga
     3361 tatctaaaat acagtctaca tctggctcga agaaagcggc agcatagtaa tgtgccattg
     3421 tctctacttc gccgtggtca agctgcagtg cagccttaat taatgcttca ccgtaaccag
     3481 tagaacagga accggaaatc ttcgcagcag gaggaagtaa ctcctttaac tctttcatag
     3541 cacgaattgt tgtatttaac ggacttccgt tattattatc gtagaaacgg tataagaggg
     3601 aaccatcttc tccaactaaa gcaagctttg ttgtcgtaga tccggcatca ataccgagat
     3661 agcatttgcc actgtaggta gctaagtctg cctttttcac cttgaattgg ttgtgctctt
     3721 cgataaattc atcatattct ttttcgtctt taaaaagagg ctccatacgt tctacttcta
     3781 cagcaagctg aatgtcggat tcaaactctt ttaagagatc atctaatgtg aaggaacatt
     3841 cttcttttgc gtttaatgcg gcaccttttg ctgcaaaaag atgagagtat ggagggtcga
     3901 taatatgttc ttcgtccaga tttaaagtac ggataaatgc attctttaat tctggcataa
     3961 agtgaagagg accaccaagg aaagcgacat atcccttgat tggtttacca caggcaagac
     4021 cactgattgt ctggtttact acagcctgga agatagaagc agcaagattt tcttttgttg
     4081 ccccctcatt gattaatggc tgaatatcag actttgcgaa aacaccgcaa cgagcggcga
     4141 ttggatagag ggtatcgtaa tcacgggcat attcattaag accggttgca tctgtctgta
     4201 aaagacttgc catctggtcg atgaaagaac cagtaccacc ggcacataca ccgttcatac
     4261 gctgctcaat tccgttatta aaataaataa tcttggcgtc ttcaccgcca agttcgattg
     4321 ctacgtctgt ttttggttca taatcctgta aggcattcgc cacacaaact acttcctgac
     4381 agaatggaat atgtaagtat tctgagattg ccatcccacc ggaaccagtt acggttggat
     4441 ggattgtgag attgcttagc ttttctctcg cctcagataa taaggtctgt aaagttcctt
     4501 taatatttgc aaaatgtcgt ttgtaatcgg aaaaaaggat atcatggctc tcattgataa
     4561 ctgttacctt aacggtagta gaaccaatat caatacctaa tgcgtgtttc atgattaatt
     4621 aatcatctcc tttagtaaaa tgtgtattca tgttgtgtat taaaataagg taatctaatg
     4681 ttcagaatac atttataaca ccgtccgcga tacacttcgc ttgccgatgc caccgtatcg
     4741 tcttgttcag tcactttgtt gatgaaaaag cattctgcgt tatttgacag aaaggcaatg
     4801 agacagacac tatggctctg aatcactata tatagataaa tttctcaata tccaaaccat
     4861 tataaacgag ttgaacgtaa aatacaacaa atttcgaaaa aaagatataa tgaatggaaa
     4921 atgtttacaa aaagcaaaag aagaggggag tatttgtatg aggagttttt cacgataaag
     4981 tacctttttc tctgactgtc atattttata attgaggaag aaaaaggaag agcatctatg
     5041 agtgaaaaag tttatgtaaa catatgtgac accaaaaaat gccccggccc ggtgtatgca
     5101 gtaaagacag gagatacgct gtatagcatt gcacaaaggc atcattgccg ggtaagaaca
     5161 cttcttgatc taaacccttt tgtagatata tataatttgc agccgggtga ggaaatctgt
     5221 gtaccagact gcaggggaca ggggaaagta gatttccggc cttatgtagt aaaagaaggg
     5281 gatacattaa aaattatcct gaaaaatgtt tcaatgacct ttgaagaatt agcaaaggta
     5341 aaccgtattt tgtataatct tactgtacca gcgggaacga ttctgctcgt tcctgcaaaa
     5401 aaagaataaa tgaaaaagaa aagcagttaa aaaatagtaa aaaaatcaca gaaatgcgtt
     5461 tgacaaagta ttagatattt cttataataa atttaaacgg tttcagttat gtaagagtcc
     5521 gcgaaacgga ctctttcttt cgttttgcca agatagagaa gatgcagact gagatacgat
     5581 aaactgttga aagagggaag tctcatgata agaattttta aaacgaccga ttcagggatt
     5641 cgcaaagttg cagtggcaga ggaaggatgc tggatagccc ttaccaatcc tacggcagaa
     5701 gaactaagta ccacagcaga ccagtttaac attgatgttg acgatttaaa aagccccttg
     5761 gatgaggagg aacgttcccg tatacaggtg gaggaaaatt acacattaat tatcctggat
     5821 attccaacaa tcgaagagcg taagggaaga gaatacttct atacgatacc gtttggaatt
     5881 atctttactg ataagtatat atttaccgtc tgtcttgtag actcaccggt actgaccgta
     5941 tttatggatg gaagagtgag ggatttttat acgtataaga gaactcgttt catctaccag
     6001 atgttatacc gcaatgcgac gatgtttctg cagtatctga agattattga caagaagagt
     6061 gatgaagtgg agaagaagct tcacatttct cagagaaatc aggaattgat tgaaatgctt
     6121 gatttagaga agagtcttgt atattttaca acttctctgc gaggcaacga ggttgttctt
     6181 gagaaactga tgcgtaatac atccattcca cgttatgaag atgacgagga gttacttgaa
     6241 gatgttatca tcgagaataa gcaggcgatt gagatggcga agatttatag tgatatttta
     6301 agtggaacaa tggatgcctt tgcttctgtt atatcgaata acttaaatat tgcgatgaag
     6361 tttttgtcag ttattaccat tgtgcttact gtaccaacga ttgttacaag tgcgcttggt
     6421 atgaacgtag caggaattcc atttgcgaat aatccatatg gattttggat tgttgtagga
     6481 atctctttat tactgactct gattgccgga gcaatcattg ccaagaataa acattttaaa
     6541 taattgaata tgtatgagac agccgggatt tccggctgtt catttataaa caaaaatatt
     6601 ttattaagaa tgtacgcttg ggatttttac tgcacttgtt tttgcagaag gtttcttgtc
     6661 agtacattga aagttaaagg aggagtgcca tgaattggct agataagctg gaacgtaaat
     6721 ttggaagata tgcgatacga aatctgccgc tgtatatcgt tatgctgtat gcgataggag
     6781 cggtacttaa tattttgaca aagggttctt attactatta tgtcgcatta aatccgtata
     6841 tgatacttca tggacagatt tggagactgc ttggtttcct tattgtgcca ccgaatgcaa
     6901 gtctcatttt tattattttt gtactgatgt tttactattc gattggagaa tctttagtac
     6961 aggtatgggg agcatttcgc tttaatatgt atatccttat aggagttctt gcgacaattg
     7021 tggcatcatt tattgtatat tttatttatc catcaacaat gattttcatg gatacttttt
     7081 atttgaactt atccatgttt ttagcctacg ccacgatatt cccggagatg cgggtatatc
     7141 tttatggtat tcttccgctg aaagtaaagt ggatggcgtg gtttgatgtg gcgcttttag
     7201 tttggcagtt tgtcgttgga ggacttggag caagaattgc tattgtagta agtttactga
     7261 actttctgct gttttacttc tcatcaagga attataaaaa ggtttctcca aaagagattc
     7321 acagaaagag agcataccgg aaggcatcat ctgtggcttc aaataaacca tatcgtcata
     7381 agtgtgcagt ctgtggtaag acagaattag atgacccaaa tttagaattc cgttactgct
     7441 caaagtgtaa tggaaattat gaatattgca atgaacattt atttacacat acgcatgtaa
     7501 aataaagcaa tattaaaaga gttatattct ttcaaataaa tctgaaaaat taatggatag
     7561 aataaagata taatataagt tgcaaataaa tcatgacagg aggcggtctt ttgttgacaa
     7621 tatcagaaca tataatgatt ggggagacga tttcccacga tgcgaaggct atattgcggg
     7681 gagtccgcca tccttttata tggaagaaag gactttggta tggtattacg acttcctgtg
     7741 ggaaagatgt gatcatgtat attctttctt cacgagagat gagacagaag ttttatcaga
     7801 acaatgattt aaagctgttg ggacttgcag gttctatgaa agaggcttat gaaatcgtgt
     7861 taaaacttgt gcagatggga tataatagtg attgtatcta tgagatgaat gattatctgg
     7921 agaagtttta aaacaggagg agaaatgtgc tgtatgtatt attattacta ttaaaaatac
     7981 ttggaatact gctcctgtta tttatcggac ttgttttgct tgttttgcta acgccgattc
     8041 ggtattcttt tgaactcgaa aaggaggaac agaaggaacc aaagtttatg gtaagagtta
     8101 cctggctgtt ctggcttttt tattttaaga ccagttacat agagaaggtc tttaattacc
     8161 ggatacgtat actggggtat cagattgccg ggaatcagcc ggaatttctt gaaaaacaga
     8221 aagaacggca aaaaaagaag tctcaaaagg aaaaagcaaa agaagaacgt aaaacagcag
     8281 agacactggc agagggaaaa agtagaagca tagattctgt ttctaaacag aaagcggaaa
     8341 aggcagtccc taaagagaaa tcctcagatg tgtcagaagg cagagaaaaa acaaaagaga
     8401 aagactctgg agatgataaa aatagtaaag ataagaaaaa gaataaagaa aaaaagcaaa
     8461 aagatggaaa gaaaccaaag aaagagtctt ctttaaagaa aataaaaagc aaaataaaaa
     8521 gcttaaaaga aacaaaggtt aatttagata aaatgccgtg gcgggaatgg ttagagctgg
     8581 gaaaggacgt tcttattcgc tttctaaagc atgctcttcc gggaaagcta gaaggaaaca
     8641 ttgcatttgg aactggtaat ccggaatata caggatatat tacaggaatt gcggctgttt
     8701 tttattcgaa gtatggagaa catttttctt tatatccgga ttttgaaaga aagatgttcg
     8761 aggccaagtg caggggaaga ggaagaatcc ggctgggata tatgcttgtt ctggctgttt
     8821 ctatattaaa agagaaaagt gtaagaacaa tgattaaaaa catcatttta ggttaaacag
     8881 gagggcgtac aatggataaa caaaactttg atacaacagt gaattcttta tttagtggaa
     8941 tggaccacgt attatcttca aagacagttg ttggagaacc acaggttatt ggagatacga
     9001 ttattctgcc acttgttgac atttcctttg gaatgggagc aggtgccttt aataaagaaa
     9061 agggaagcag tgcaggcggt ggaatcggag gtaaaatgtc cccaagtgct attttagtta
     9121 ttcataacgg acagacaaag cttgtcaata tcagagatca ggatgccgtt accaaagtac
     9181 ttgatatggt tccagatgcc gtaaataaag ttgtttctat tattaaggga gaggacgcag
     9241 aggacaaagt tgacccggaa gtagaatctg cggtgaataa agcagcacag gcagaggctt
     9301 ctgttgtaga tgtagatggc gcaggaattt aaaaggtatt cggtattcag ttaacgtgag
     9361 attaccacgt tactttcgtg caggaaaaat cttccacgaa gtgtaatgca tatcgtatag
     9421 aaagcggttt ttaaacacac tttgggttgc cttagatcaa tcaaataaaa aaagtgaaga
     9481 tttttaaaag ttttccttgc aatttgtttt gatttctgat agtatagact cgttgtaagt
     9541 ctgtcagact taagtatatt cgcgaggagg tgctatcatg gcaagatgcg ctatttgtga
     9601 caaaggtgct catttcggta tcaaagtgag tcattcacat agaagatcaa acaaaatgtg
     9661 gaaatccaac attaagtctg taagagtgaa agtgaacgga gcttctaaga aaatgtatgt
     9721 ttgtacttct tgtttaagat caggtaaagt agaacgtgcg tagttttact gtcactgagg
     9781 ataagagaag actctaatct ttgtccttac aggaatgtat gcagatatga gttaagaggg
     9841 aatcagtgat tccctctttt ttcttttctg ttaaaatcgg tcacaaaaca gcagatatcc
     9901 aagcaggatg ctgatgacca gaataatgaa ctttactgca aagccggtga gaaagcagct
     9961 caggaacaga ccaaaggaaa agcaaaaaag agcgaatccg cataattttt tcataaaatc
    10021 tccccaatat gttccttata atagtatatg ggaagatact tcttttgttt caggagaaag
    10081 tacttaaatg gaagaatttt atgtttgtgg ttccaatttc accgaaaaga ggttatacta
    10141 tagaaaacga taataaaacg gagggatagt atatgaaggg acaaatgcac accgatttag
    10201 gtcaggttat tatagatgaa gaggttattg caacttatgc cggaattaac gcgattgagt
    10261 gttttggtat cgttggaatg gcatctgtga atatgaaaga tggttttgcc cagcttttaa
    10321 agagagacaa tgtaagcaag ggcgttcata tcaagataaa tgataacaag atttatatag
    10381 attttcatat tattgtagta tatggtgtct ccatagctac agttacagag aatttaattc
    10441 agaatgtaaa gtaccgcgtg gagaagttta ccggtatgag tgtagagaaa attaatattt
    10501 atgtagaggg agtccgtatc gtagattaga acgtgtttga aaaatgcttt ctgcaaattg
    10561 gggcgtgcag gttgctggaa tgatttttca aacacgctct aagataacgc tttagaaggg
    10621 attccttttt atagaataaa agaacaagat aactactatg aattatagat aaaacaggta
    10681 aataaggagg aaatgttgtg aacagtcaca ccatagacgc aaaaactttt cagaaattgt
    10741 ttttagccgg tgcaaaccgt attaattcca gaaaagatta tatcaacgaa ctgaatgtat
    10801 ttccggttcc cgatggagat accggaacaa atatgtccct gacaatttta gcagcagcta
    10861 aggaagttgg agcagttgct gaacctacaa tggctacaat atgtaaagct atcagcaatg
    10921 gttctcttcg tggagcccgt ggtaactctg gtgtaatcct ttcccagcta ttccgaggat
    10981 tcacaaaggc agtttctaaa gcggattctc ttggtaagga tgagattaca gccggattta
    11041 caagagcagt agagacagcg tataaggcag ttatgaagcc aaaagaagga actatcctta
    11101 cggttgcaaa aggaatggca gataaggcag aagagttagt cgacgaggat atggatgtta
    11161 tcgcattctg cgaggcaatc gttgcctacg gctacgaagt cctttctaag acaccagata
    11221 tgcttccggt attaaaagag gcaggtgtag tagattctgg cggacagggt cttatggaag
    11281 tgttacaggg aatcgttgat gctcttaccg gcaaggtaac agacattgaa gttccggcag
    11341 aggcagcgtc tatgtcatct gcagtaatca gtgcaccaaa agcagatatt tctacagcag
    11401 atatcaaatt tggctactgt acagaattta ttattttgtt agataagccg ctcacaaaag
    11461 aagatgagaa gggattaaag aagttcttcc tttctatagg tgattcttta gtattagttg
    11521 cggatgaaga gatttgtaaa gtacatgtac acacaaatca tccaggagaa gcctttgaaa
    11581 aggccttaac atttggtgcg ctttctaata tgaagattga caatatgcgc ttagagcatc
    11641 aggagaagct catcaaagat gcagagaatg aggcagcccg tcagagacag caggaagcag
    11701 aagaagagaa acttgccgct aaagaagcag ctgcagaaaa accagccaaa gaagttggat
    11761 ttattgcagt atctgttggt gagggactta ccgatatttt caaaggtctt ggtgtagatt
    11821 accttattga aggcggccag acgatgaatc ctagcacaga ggatatgctt aacgcaatcg
    11881 agcaggtcaa tgcaaagaat atctttatcc tgccaaataa taagaatatt attcttgcag
    11941 cagagcaggc cagagattta acagaagata agaaaattat cgttcttcca acaaagacaa
    12001 ttccacaggg aatatccgca atgattggat atatgccaga agcaggtgtg gatgagaacg
    12061 aagagaatat gaaagaggct tatcaggata ttgcaagcgg tcaggttact tacgcggtac
    12121 gagacacagt aattgatgga aaggaaattc ataatggaga catcatggga atcaatgatg
    12181 atggatcgct gcagtaggaa agaatcttac tgagacaaca ttagaattac tttctacaat
    12241 ggcagatgaa gattcggaac ttatttgcct ttactatgga gccgatgtaa ccaaagatga
    12301 tgcagataca ctttccgatg caattgagga taagttccca gaatgtgaag tagaggtcaa
    12361 ctttggcgga cagccaatct attactatat gatttctgtc gagtaagata aatgaaataa
    12421 tgatataatg aaaaaagagg gaataaatca ctcctttgtg gcagcaattc cgtgtattga
    12481 catggaatcg ctgctatttt catataagag tgttttgatt aagataaaat aatattacca
    12541 tatgatgcat gtggaggaag gagaatctca gttgggaata ccagtaaggg aaattaaagg
    12601 aattggagaa aagacggaaa agttacttgc aaagcttgac atagagaccg tggatcagtt
    12661 ggtgcatcac tatcctcgtt gctacacgac ttatccagag ccaatttcca tatcagagat
    12721 aaagacagga caaagatgtt cgattgaggc agaaatcgct tccccgattc atctaaagac
    12781 tgttcggaag ttaaaacttt gtaccgggct tatcgcagat gtcagcggac agctttttgt
    12841 gcgctggttt aatatgccat atcttcgaaa tacattaaaa cagggagaac ggtggatttt
    12901 tacaggaacc ccgatttata aagatggacg tcttatgtta gaacagccgg agcactgtaa
    12961 gagggaaaag tatttgcagt taatggaaac atttcagccg atttaccctc tcacaacagg
    13021 attgtcgaat aagacagtac aaaaagcaca ggcagctgca tttgaaatgt acagagaaga
    13081 agagtatctt ccggaaaccg ttcgaaatta ttatgattta gaaccagtga atacagcact
    13141 tagagaagta cattttccta cagggaccga acatttgatg gaggcgaaaa agcgaatcat
    13201 ttttgatgaa tttttccgtt ttttcagtgc gttagaactt gtcaaagaca gggaggaaca
    13261 agcactcaat cactatatta ttccaatgga agaacccgta aagaggtttg tagaaaattt
    13321 accgtatcct cttacagggg cacaaaaaaa ggtgttaaat gaaattcgcc aggacttttc
    13381 cgatacaatg gcaatgaacc gccttttaca gggagacgtt ggttcgggaa agacgattgt
    13441 agcaatgaca gcgatgtatg ctgctgttct tgccggttac caagcggcgt tgatggctcc
    13501 gacagaggta cttgcagaac agcattacca gaactttgtg aaactccttt ccccacttgg
    13561 gattaccgtt gccctgctta ccggttccac aaaagcaaag gaaaaaagag agataaaggc
    13621 agcctgtgcc tctggtgaga ttcagatttt aattggaacg catgcagtga tacaggacga
    13681 tgtagctttt gacaatcttg catttattgt taccgatgag cagcatcgtt ttggagtaaa
    13741 acaaagagat gcctttatga aaaaagggaa agatccccat gttcttgtaa tgagtgcgac
    13801 gccgattcca cgtacactgg gaattatttt gtacagagat ttagatgtta gcattatgaa
    13861 tgaaatgccg gcttccagac tgccgattaa aaattctgtt gtgggaactt cctatcgtcc
    13921 ggctgcatgg gaatttataa gaaagcaggt agcacttgga catcaggcat atgtgatctg
    13981 tccgatgatt gaggaaaatg aaaaaatgga tttggaaaat gtggaagagt atgcaagaat
    14041 gctttcgcag gcattaccgc cttctattac cgttgaagct ttaaatggac atatgcgccc
    14101 ggcagaaaag aatgatatta tggaacgctt ttcgaagaat gaaattcaga ttttagtttc
    14161 tactaccgtt gtagaagtcg gtattgatgt tccaaatgca accgttatgc tcatagagaa
    14221 tgcggaacgg tttggccttg ctcagctcca tcagctccgc ggacgtgttg gaagaggaaa
    14281 agcacagtca tactgtgtct ttatttctgg ttcagaaaaa gaagaagcga tggaacgttt
    14341 ttccattatc ggacattcta atg
//
