LOCUS       c00190_gnlPro..        15156 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KLOCNCOL_222.
ACCESSION   c00190_gnlPro..
VERSION     c00190_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:54:23
            Original ID  :: gnl|Prokka|KLOCNCOL_222
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15156
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15156
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[183:5156]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      184..5156
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15156
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15156
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             184..1608
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg190_1"
                     /sec_met_domain="CT_Vparvula (E-value: 3.6e-137, bitscore:
                     448.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPIIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDSNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGEAVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPRASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             1621..1965
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg190_2"
                     /sec_met_domain="OAD_gamma (E-value: 1.3e-27, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSTDKLV
                     VRSIKRVKRR"
     CDS             2060..2428
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg190_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             2462..3586
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg190_4"
                     /sec_met_domain="OAD_beta (E-value: 2.6e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             3744..5156
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg190_5"
                     /sec_met_domain="HMGL-like (E-value: 6.5e-43, bitscore:
                     138.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 8.9e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVNATKKEGGHAQVALSYTIGDAYTLDYWKN
                     TAKNIEEMGADSLCIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAMSPFAMGTSQPATEVMAETFRDTEFDTGFDQKLLGEIADYFRPIREK
                     YLANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             5454..6602
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg190_6"
                     /sec_met_domain="Aminotran_5 (E-value: 4.6e-78, bitscore:
                     253.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIYFDNGATTRALPQVREIMDEVLEKEYGNPSSMHMKGFDAEK
                     YVNHAKEIIAKSLKVDPKEIYFTSGGTEANNLALIGTAFANKRERKHIITSCIEHASVY
                     NPLSFLEDEGFEVTYLPVDEHGIVDLEVLKKALRKDTLMVSIMCVNNEIGAIEPVEEIG
                     KIVKSFDPKILFHTDCIQAYGKLNCYPKKWKADMISVSGHKIHGPKGIGFIYIKNGTKI
                     KPIIWGGNQQKGMRSGTENVPGIAGLGKAAELIYENHEEKIAHIREIKDHFIKRVMEEI
                     PDVKDNSGDAPHVASISFLGVRSEVLLHALEEREIYVSAGSACSSNKPEVSGTLKGIGL
                     TKEYYESTLRFSFSIFNTVEEADICVEALKELLPMLRRFTRR"
     CDS             6699..7883
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:Thiamine biosynthesis protein (Score: 226.6;
                     E-value: 6.8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg190_7"
                     /sec_met_domain="ThiI (E-value: 3.2e-70, bitscore: 226.6,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFKAFLIKYAEIGIKGNNRRFFEDALVRQMKYALKPVGNFSIRK
                     ESGRIFVHANEEYDFDEAVESLSHVFGIAGICPIVVEEDKDFEKIAEVVEKYVDEDYAD
                     KHFSFKVHVRRADKKYPIPSMEAAARLGERLLEKFEDLSVDVHNPDVMLTVEIRDKVYI
                     YSREIPGPGGMPVGTNGRAMLLLSGGIDSPVAGYMISKRGVSIDATYFHAPPYTSERAK
                     QKVVDLAKEIAKYTGPITLHVVNFTDIQMAIYEKCPHDELTIIMRRYMMKIAEHFANQD
                     NCLSLVTGESIGQVASQTMHSLYVTNEVCQMPVFRPCIGLDKNEIVKVAEKIGTYETSI
                     LPYEDCCTIFVAKHPVTKPRLDVIKRSERNLDDCIDELMKTAIETTEEIKINAH"
     CDS             complement(8143..8379)
                     /locus_tag="ctg190_8"
                     /transl_table=11
                     /translation="MKTIKISLNSIDKVKTFVNVINRFDAEFDLVSGRYVIDAKSIMGI
                     FSLDISKPIDLNIHNADNLDEIMEQLQPYLVTE"
     CDS             8612..9964
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg190_9"
                     /sec_met_domain="Radical_SAM (E-value: 5.5e-30, bitscore:
                     95.9, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRRAAFLTLGCKVNQYETDAMEEILEKAGYEIVSFKETADVYI
                     INTCSVTNMADRKSRQMIHRAKKNNPDAIIVAAGCYVQAAEEELAKKNEADILVGNNKK
                     KDIAQILEEYFAAKEPEQEVPVVSEVIDINHTKEYEDLTIHKVNEHTRAYIKIQDGCNQ
                     FCSYCIIPYTRGRIRSKNPEEVIEEVKNLAAQGYKEIVLTGIHLSSYGKDLGIVTLLDV
                     IKRIQQVEDVERIRLGSLEPRIITEEFVKELVKCDKVCPHFHLSLQSGCDETLKRMNRK
                     YTTEEYEEALNILRKYYEHPALTTDVIAGFVGETEEEFEKTRAYLEKINLYEMHIFKYS
                     VREGTRAQKMSGHVPEQVKTERSEVLLSMAKRHKTAFEEWYVGRKEKVLLEEIVEKNGK
                     KYFQGYTAHYVKVAVELTENDTKLEQNEVIVVDIQGFIDENLLYGKVSIEF"
     CDS             10019..10276
                     /locus_tag="ctg190_10"
                     /transl_table=11
                     /translation="MGRNNTQFFHVVKEQEYDVASILKDVYEALTEKGYNPVNQIVGYI
                     MSGDPTYITSHKNARSLIMKVERDEILEVLFENYIDTQLK"
     CDS             10279..10716
                     /locus_tag="ctg190_11"
                     /transl_table=11
                     /translation="MKERWMGLDYGTKTVGVAVSDALGITAQGVETVTRKSNKKLRQTL
                     ARIEALIEEYEVSKIVLGLPKNMNNTLGERAEETKEFQAMLQRRTGLEVVLWDERLTTM
                     ESERILQEGGVRRENRKERIDWMAATLILQSYMDVHPIPEK"
     CDS             10756..11043
                     /locus_tag="ctg190_12"
                     /transl_table=11
                     /translation="MNNYQSIPFKDEDGKEKEFYVLEQTTLNGFHYLLVEDGSADADDE
                     EVEVLIMKRVADAAEDEEWATYEMVEDEEELISVSKVFEQLMDDINFEVE"
     CDS             11165..12829
                     /locus_tag="ctg190_13"
                     /transl_table=11
                     /translation="LKVTGNQSVKIIPLGGLEQIGMNITAFEYEDSIIVVDCGLAFPDD
                     EMLGIDLVIPDITYLKENASKVKGLVITHGHEDHIGAIPYALKELNMPIYATKLTMGLI
                     ENKLKEHNLLRTTRRKVIKHGQSINLGRFRIEFIKTNHSISDAAALAIYTPAGIIVHTG
                     DFKIDYTPVFGDAIDLGRFAELGKKGVLALMCESTNVEREGYTPSERTVGRTLRHLFDE
                     NKDHRIIVATFASNVDRVQQIIDCAYSCGKKVVIEGRSMVSTISTAAELGYIKIPDNTL
                     IDIEQMKNYVDEQLVLITTGSQGETMAALSRMAASTHRKVSIKPGDVIIFSSHPIPGNE
                     KAVSKVMNELAKKGASVIFQDTHVSGHACQEEIKLIYTLTKPQYAIPVHGEYRHLKRHK
                     DLAIEMGIPKENVMILQSGDVLTISKEQAKVTGHVPAQGILVDGLGVGDVGNIVLRDRQ
                     HLSQNGLFIVVVTLDRYNGVLLAGPDIVSRGFVYVRESEKLMEEAKSVVTNTLEHCNSK
                     KITDWGRIKGAIRDDLGDYIWKKMKRSPMILPIIMEV"
     CDS             12833..13222
                     /locus_tag="ctg190_14"
                     /transl_table=11
                     /translation="MMDEGKLSIPFFPDTEDIRQGTKKLTDMICHTEDYKCYQKDLTVL
                     KEQEELYRKFKEFRGKSLYLQLEKGQEQYFEKIESLHSEYKDVLTEPVVVDFLSAEQRM
                     CKLMRLVYDGIAENIKLDLSYMDEL"
     CDS             13219..13329
                     /locus_tag="ctg190_15"
                     /transl_table=11
                     /translation="MITSHIGLFRFRKLQTICRTKNVRREMNIHFGFTND"
     CDS             13436..13804
                     /locus_tag="ctg190_16"
                     /transl_table=11
                     /translation="MAEKVLHVIIKILMYIFIVLLFILLFVRMSGVGRAIFADKPKDKN
                     PQIASETVLVVEQGESLLEISKDLAEQGIVKNPYLFAISLRCMDGYQNIRPGEYQVSSS
                     EKPSEILKQLTHEEEKIQ"
     CDS             13801..14448
                     /locus_tag="ctg190_17"
                     /transl_table=11
                     /translation="VITEERVLDFIRSFGVDRGSEALHMIEKEAIRDDVPIIRKESGEL
                     LRILLQIKKPEKILEVGAAIGFSSVFMGENTDNNTHITTIENYPPRIERAKVNIALAGM
                     EDKITLISGDAAEVLKELSGSWDFIFMDAAKGQYIHFMPEVMRLLAPGGILVSDNVLQD
                     GDIFESRYGIKRRNHTIHNRMREYLYALTHDEALDTVILETGDGMAISVKKE"
ORIGIN
        1 agaattgtta aaaaaatttg caaataggca gaatgttcat tttgtttagt ggaatgggca
       61 aaataaaata aatgttaaat aactaacaga aaatggttgc taacatgata ataatttgtt
      121 attattacat agaatgaaag agcaacaagg tatacaatat agcattttta tggaggaaag
      181 aatatgggta attcaaaaat gaatgccaga gagcgcattg attatctgtt tgatgaccac
      241 agttttgtgg aagttggtgg atatgtttcc gctcgtaata ccgattataa tctcggtgca
      301 aagaaagtag aaggtgatgg tgttatcact ggatacggag ttattaatga ccgcatggtt
      361 tatgtttaca gtcaggatgc ttccgcactt ggaggttccg taggtgagat gcatgcgaag
      421 aaaattgctt ccctttatga tctggcgatg aaaacaggcg cgccaatcat tggaatgctg
      481 gattgtgcag gacttagatt acaggaagcg acagatgccc ttcacgcttt tggaacgatt
      541 tttaataagc aggcacaggc atctggaatg attccacaga tttctgcagt atttggaatg
      601 tgtggaggag gaagtgccgt aatgtccgct atgtctgatt ttacattgat ggagaaggag
      661 aacggcagtc tctttatcaa cagtccgaat gcattagcgg ggaatgaaga atcccgtcag
      721 aatacggcag gagcacagtt ccagtctgag caggctggta acgtagattt tgtatgtgag
      781 acagaagaag cacttcttga ccagcttcgt attctcgttg atgtacttcc ttctgattat
      841 gaagcagaag atgtttactt tgataacgat gatgatttaa atagggttat tcctgagtta
      901 aatgatgccg catatgatgc cgcttacatt ttaaaatcta tttctgacag caatatgtac
      961 atagagacaa aggcagccta tgccaaagag atggtaactg catttatccg tctgaatgga
     1021 gagacagtag gtgcggttgc aaaccagcca gtagatggtg aggccgtttt aacaagaaat
     1081 ggtcttgaaa aagcagaaag atttattaag ttctgtgatg cattttcgat tcctcttctt
     1141 actgtaacga acgtgacagg acttcgtgcc aacgcacatg aagagagaaa gcaggctctc
     1201 gcattagcga agtttacgac aacacttgca caggttagtg tacctcgtat taatctcatt
     1261 gcaggcgagg cttatggaac tgcagcggaa gtaatgaatt ctaaagctat cggagctgac
     1321 tttgttctgg catggccacg ggcatctgta ggaatgatgg atgcagaaca ggcagttcgt
     1381 atcatgtatg cagaggaaat caatacagat aagaataaga cagcacttat tgcagagaaa
     1441 actgcggaat atgcagaagg acagagcagt gcattagcag ctgcaaagag aggatatata
     1501 gatgacatca tcgagccgga cgcaacaaga aagcgtctta tcgctgctta tgaaatgctt
     1561 tacggaaaga aagtaactcc agtgacaaag aagcatacgg cagtatagtg aggtgagagt
     1621 atgaacgtat ttgaacaagc cttattaaat actttgatgg gtatgggaac tgtatttgca
     1681 gtactgattt tcatttcttt actgatttct ctttttgtat atatcccatc tattgaaaga
     1741 gcgttaaaga atcgttcttc taagaaagag aaaaaggctg cgcaggaaga aagaccggct
     1801 ccaaagcgtc cgattcttga agaagttgtg gaagaagagg aacttgtgga tgatggtgaa
     1861 cttgtcgcag taatcacagc ggcaatcatg gcagcgaatg gaggagcagc agtcagtaca
     1921 gataagttgg tcgttcgttc aatcaagaga gtgaagagaa gatagcaaaa atgtattctt
     1981 ggaatctttt tataaagttt tgaaaagtta gctatagaaa gattttagaa gtacataaaa
     2041 tcattcagga ggatttacaa tgaaaaatta tagaattaca gttaatggtg ttgcttatga
     2101 tgtagcagta gaagaattag gtgcaggaga agcaagtgca gcgccggtaa gtacaccagc
     2161 agccgttccg gctccagcta agaaagctgc cccaaagact tccggaagtg ccggtgccgt
     2221 aaagattaca gcaccaatgc caggtaagat cgtagcagta aaggcacagg caggtgcttc
     2281 tgtaaagaag ggcgacgctg ttcttgtatt agaggctatg aagatggaga atgaaatctg
     2341 tgcagcacag gatggtgtta tcgcaagtgt ggaagtagca gttggagata tggtagaagg
     2401 cggagatgta ctggctacaa tgaactagag catatttgca aaataaaacg gaggaagatt
     2461 tatgagttat gttgtagaga caatgacgaa tctcgcagca cagaccggat ttgcattctt
     2521 aaagccaggt aacttcatta tgatactggt tgctttagtc ttcttatatc tggccatcgc
     2581 caaaggatat gagccacttt tgttagtgcc gatttctttt ggtatgctgc tagttaactt
     2641 atatccgtcc attatggaag aaggcggatt attacattat ttttacttat tagatgaatg
     2701 gagtattctc ccttcactga ttttcttagg cgttggagca ctaacagact tcggtccgct
     2761 gattgccaat ccagcaagtt tcttgctagg agctgcggcg cagtttggta tttacagcgc
     2821 gtatttcctt gcaatgctta tgggatttaa cggaaaggca gcagcagcaa tttccattat
     2881 tggtggagcc gatggtccta cttctatttt ccttgccgga aagcttgggc agacagactt
     2941 aatgggacca attgcggtag cggcatattc ttatatgtca cttgtaccaa ttattcagcc
     3001 accgatcatg aagctcctta ctacagaaaa ggaacgtcag attaagatgg aacagttaag
     3061 aaccgttaca aaaacagaga aaattatgtt ccctatcgtt gtaacagttg ttgtatgtct
     3121 gattcttcct acaacagcac cattagttgg tatgctgatg ctcggtaacc tttttagaga
     3181 gtccggcgta gtaaaacagc tttcagagac agcgtctaac gctcttatgt acatcgtagt
     3241 tattattctt ggtacatccg ttggtgcgac aacaagtgca gaggcattct taaatgtcag
     3301 cacaatcaag attgtagtat taggtcttgt agcttttgct gttggtactg cagcaggtgt
     3361 cctgtttggt aaacttatgt gtaaggttac aggtggtaag gtaaatccat taattggttc
     3421 tgctggggta tctgccgttc ctatggcagc ccgtgtatcc cagaaagttg gtgcggaagc
     3481 agatccatca aacttcttac tgatgcatgc gatgggacca aacgttgccg gagttatcgg
     3541 tacagcggta gcagccggaa catttatggc aatttttgga gtataattta gaattatttg
     3601 attatttaaa attcattatt tatagggcta taatctgtaa aaaatgttac aggggatatt
     3661 tataaatagt ttacaagttg aattttagat aataacagtt gtaagcgcaa atagttacgt
     3721 gatttgaaat aaaaggagat attatggccg aaattaagaa aaaaccggtt aaaatagtag
     3781 aaaccgttct ccgtgacgca catcagtctc tgattgctac aagaatgaca acagaggaga
     3841 tgctgccaat cgtagataag atggatcagg ttggttatca tgcagtagaa tgctggggag
     3901 gtgcaacatt tgatgcctgc ctgcgtttct taaaggaaga cccatgggag agacttcgta
     3961 aattaagaga tggctttaag aatacaaagt tacagatgtt attccgtgga cagaacatct
     4021 taggatataa gccatatcca gacgatgttg tagaatattt cgtacagaag tctatcgcaa
     4081 acggaattga tgtcattcgt atctttgact gtttaaatga ccttagaaac ttacagacag
     4141 cggtaaatgc aacaaagaaa gagggaggac atgcgcaggt tgccctttct tatacaattg
     4201 gtgatgccta tacattagat tactggaaaa atacagcgaa aaatatcgaa gaaatgggtg
     4261 cagattccct ttgtatcaaa gatatggcag gtcttttagt gccgaatgaa gcaactcgcc
     4321 ttgtaactgc attaaagcag gcaacagaca ttcctatcga acttcataca cactatacaa
     4381 gtggtgtcgg tggaatgact tacttaaaag cagtagaagc aggagtcgat atcattgata
     4441 cagccatgtc tccatttgca atgggaacaa gccagccggc aacagaagtt atggctgaaa
     4501 cattccgcga tacagaattt gatacaggat ttgaccagaa gcttttaggc gagattgcag
     4561 actatttccg cccaatacgt gagaaatatc tggcaaatgg tttaatgagt ccaaaggtac
     4621 ttggcgtaaa tatcaagacg ttaatgtatc aggtaccggg aggaatgctt tccaacctcg
     4681 tatctcagtt agagcagcag ggcgcatctg ataagttcta tgaggtatta gaggaagtgc
     4741 caaaggtacg taaagatttc ggtgaaccac cattagttac accgtccagt cagattgtcg
     4801 gaacacaggc tgtattaaat gtacttaccg gagagcgtta taaaatgatt acaaacgagt
     4861 caaaagccct tcttcgtgga gaatacggtc agaccgtaaa accaatgaat aaagaagtac
     4921 agaaaaaggc aattggcgat gaaaagccaa ttacctgtcg tccagccgac cttcttgaac
     4981 cggaattatc taagattgag gcagagatga gccagtggaa agaacaggac gaagatgtgc
     5041 ttacatacgc attgttccca caggtagcaa ccgaattctt taaatacaga gcggcacagg
     5101 agaataagat tgatcctgca aaagccgatg taaagaatgg agcatatccg gtgtaggatt
     5161 gatttagatt aaaaacagac gaaaatgaaa aaggatactc ccctcaagat gtaatgtcgg
     5221 agtgagtgaa aatgcgactg agcattttgc tcgaacgact atctttacag cttgagggga
     5281 gtatcctttt tcattttcat ctgtttatct gcaaaatcca ttttacttct ctctcatttt
     5341 atgttatgtt tatatacgat tatgccattt tttatggctg ttttttgagt gtagagaatg
     5401 gaacaaaaaa acaataagac ataatatatt ttttgaagga gttgtaaacg agaatgtcag
     5461 agatttattt tgacaatggc gcgaccacaa gggcgctgcc gcaggtgcgt gagattatgg
     5521 atgaagtact tgagaaggag tacggcaatc catcttctat gcatatgaaa ggatttgatg
     5581 cagagaagta tgtcaatcat gcgaaagaga ttattgcaaa gagcctgaaa gttgatccaa
     5641 aggagattta ttttacttct ggtggtacag aggcgaataa tcttgcattg atcggtactg
     5701 catttgcaaa taaaagagag agaaagcaca ttattacaag ctgtattgaa catgcttctg
     5761 tatataatcc attatctttt ttagaagatg agggatttga agtgacctat cttcctgtcg
     5821 atgaacatgg aatcgtagat ttagaggtat taaagaaggc gcttcgtaaa gatacattga
     5881 tggtttctat tatgtgcgtg aataatgaga ttggtgccat cgaaccggtt gaggagattg
     5941 gaaagattgt aaagtctttt gatccaaaga ttttattcca taccgattgt attcaggcat
     6001 atggtaagtt gaattgttac cctaagaaat ggaaagcaga tatgatttct gtaagtgggc
     6061 ataagattca cggcccaaag ggaatcggat ttatttatat taagaatgga acaaagataa
     6121 agccaatcat ctggggtgga aatcaacaga agggaatgcg ttccggaaca gaaaatgtac
     6181 cgggaattgc agggcttggt aaggcggcag agttgattta tgagaatcat gaggaaaaga
     6241 tcgcacatat cagagagata aaagatcatt ttataaaaag agtgatggaa gagattccag
     6301 atgtgaagga taattccgga gatgctccgc atgtggcgag tatcagcttt ttaggagtaa
     6361 gaagtgaagt gcttcttcac gcattagaag aacgtgagat ttatgtatca gcaggttctg
     6421 cctgttcatc taataaaccg gaagtcagtg gtactttgaa gggcattggt cttacaaagg
     6481 aatactatga atcgacgctt cgtttttcat tctctatttt taatacggta gaagaagcag
     6541 atatttgtgt ggaagcgtta aaagaactgt tgccgatgct tcggagattt acaagacgat
     6601 aaaacaatta gaacataatg tactctcgga atctttttga gcttgatttt gtgacaagaa
     6661 agactacgag agtacatcat ataaaaaagg agatatttat ggaattcaaa gcatttttga
     6721 ttaaatatgc agaaattgga atcaagggaa acaatcgccg tttctttgaa gatgcccttg
     6781 tccgtcagat gaaatatgca ttaaaaccag taggaaactt ttctatcaga aaggaatctg
     6841 gacgtatttt tgtacatgcc aatgaagagt atgattttga tgaggcggtg gaaagcttaa
     6901 gccatgtatt cggtattgca ggtatttgtc caattgtagt agaagaagat aaagattttg
     6961 aaaagattgc ggaagtcgta gaaaaatatg tagatgaaga ttatgcagat aagcattttt
     7021 ctttcaaagt acatgtaaga agagcagaca agaagtatcc aattccgtct atggaagcag
     7081 ctgcccgtct tggagagaga ttattagaga agtttgagga cttaagtgtt gacgtgcata
     7141 atccagatgt tatgcttaca gtcgagattc gtgataaggt ttacatttat tccagagaga
     7201 ttccgggacc gggtggaatg ccggttggta caaacggaag agcaatgctt cttctttccg
     7261 gtggtatcga cagcccggta gctggttaca tgatttccaa gcggggtgta agcattgacg
     7321 caacttactt ccatgcacct ccttatacaa gtgagagagc gaaacagaaa gtagtagatc
     7381 ttgcaaaaga gattgcaaaa tatacaggac ctattacatt acatgttgta aactttacag
     7441 atattcagat ggcaatttat gagaaatgtc ctcatgatga attgacaatc attatgcgtc
     7501 gttacatgat gaagattgca gagcatttcg caaatcagga taattgtctt tccctcgtta
     7561 caggtgagag tatcggacag gttgccagtc agacaatgca cagtctttat gtaacaaatg
     7621 aagtgtgcca gatgccagta ttccgtcctt gtatcggact tgataaaaat gaaatcgtaa
     7681 aagttgcaga aaagattgga acatatgaga catctatttt accatacgaa gactgctgta
     7741 ctatttttgt ggcaaaacat ccggtaacaa agccaagatt agatgtaatt aagcgttctg
     7801 agagaaatct tgatgattgt attgacgagc tgatgaagac agcgattgaa acaacagaag
     7861 aaattaagat taacgctcac taaagtatta atggatgaaa gcattttcaa ggcagacata
     7921 agtattttga taatgtttat aatgcttgca gataagtgcc tttttaaaag gtgggaagaa
     7981 gaaatatcac taaaaatatt tgttttatct gaagattcat ataagaaaaa tttatctgta
     8041 aagaaagaac cgaggaaagt aatatttcct cggttgattt cataaataca tcacaggtta
     8101 tatataatat atccgtatac cagaaaaccc gctcttatgt aattattcag ttactaagta
     8161 tggctgtaac tgttccataa tctcatcaag attatcagcg ttatggatat ttaaatcgat
     8221 aggtttagaa atatctaaac tgaaaattcc catgatagac tttgcatcaa taacgtaacg
     8281 accggaaact aaatcgaatt ctgcatcgaa acgattgatg acattaacaa atgtttttac
     8341 cttatcgatg gaatttaaag agattttaat cgttttcata tacgcgctcc tcctaaaaat
     8401 gtctatatat attttaataa tatagtacct ttttagtgaa aaaaagtcaa tagatttgag
     8461 gaagatttgg aaaatattat ctaaagataa aggggaattt tttggcatga atctggagat
     8521 gaatgaagtt agaaaaaata ggattgcagg taggaaataa taaataacag aaaaaacgaa
     8581 aaggagaaac ggaaaaagga gatttgtttt tatgagtaaa agaagagcgg cgttccttac
     8641 actgggctgt aaagtaaatc agtatgagac tgatgccatg gaggagattc ttgaaaaggc
     8701 aggatacgag attgtcagtt ttaaagagac agcggatgtc tatattataa atacctgttc
     8761 tgtaacaaat atggcagaca gaaagagccg tcagatgatt catcgtgcaa agaaaaacaa
     8821 tccggatgca attatcgtgg cagcggggtg ttatgtgcag gcagcagagg aagaactagc
     8881 aaagaaaaat gaggcggata ttcttgtcgg taataataaa aagaaagata tcgcccagat
     8941 ccttgaggaa tattttgcgg caaaagaacc agagcaggag gtaccagttg tctcagaagt
     9001 aattgatatt aatcacacaa aagaatatga agatttaaca attcataagg taaacgagca
     9061 tacaagagca tatattaaaa tacaggatgg ttgtaatcag ttctgttcgt attgtatcat
     9121 tccttacaca agaggaagaa tccgcagtaa aaatccagag gaagtcattg aagaagtaaa
     9181 aaatctggca gcacagggtt ataaagaaat cgtgcttacc ggaattcatt taagttccta
     9241 tgggaaagat ttaggaatag tgactcttct tgatgtgatt aagagaatac agcaggtaga
     9301 ggatgtggag agaatccgtc tgggttcttt agagcctaga attatcacag aggagtttgt
     9361 aaaagaactt gtgaaatgtg ataaagtatg tccacatttt catctttctt tacagagcgg
     9421 ctgcgacgag acattaaagc gtatgaaccg caaatataca acagaagaat atgaggaagc
     9481 attaaatatt ttaagaaagt actatgagca tccggcatta acaactgatg ttattgcagg
     9541 ttttgtcgga gaaactgagg aagaatttga aaaaacaaga gcatatcttg agaaaatcaa
     9601 tctatatgag atgcatattt ttaagtattc tgtacgagaa ggaacaagag cacagaagat
     9661 gtccgggcat gtgccggaac aggtaaagac agaacgttcc gaggtgcttc tttcgatggc
     9721 aaaaaggcac aagacagcat ttgaagaatg gtatgttgga agaaaagaaa aagtactttt
     9781 agaagaaatt gtagagaaaa atggtaaaaa atattttcag ggatatacgg ctcattatgt
     9841 gaaagttgca gtggaattaa cggaaaatga tacaaaatta gaacaaaatg aggtaattgt
     9901 agtagatatt cagggattta ttgatgaaaa tttactgtac ggaaaagttt cgattgaatt
     9961 ttaatgtcac tcatagtaaa atatttattg attgtaaatc tgctagaagg aggtagacat
    10021 gggtagaaat aatacacagt tttttcatgt ggttaaagaa caggaatatg atgtagcatc
    10081 tattttgaaa gatgtatacg aagcattaac ggaaaaagga tataatccag tgaatcagat
    10141 cgtgggttat attatgtccg gagatccgac ttatattacc agtcataaga atgcgagaag
    10201 cttaattatg aaggtagaac gtgacgagat tcttgaagtt ttatttgaaa attatattga
    10261 tactcagtta aagtaattat gaaagaaaga tggatgggtc ttgattacgg gacaaagaca
    10321 gtaggtgtgg cggtaagtga tgctttgggt attacggcac agggagttga gacagttacc
    10381 agaaagtcga ataagaagct gcgccagaca ttggcaagga tagaagcgct catagaagaa
    10441 tatgaagtga gtaagatagt actcggattg ccaaagaata tgaataatac gctgggagaa
    10501 agagctgagg agacgaagga gtttcaggcg atgcttcagc gcagaaccgg attggaagta
    10561 gtcttatggg atgaaagact gactacgatg gaatcagaga gaattttgca ggaaggcgga
    10621 gtgcgccgtg agaacaggaa agaacgcatt gactggatgg cggctactct gattctgcaa
    10681 agttacatgg atgtacatcc aattccggaa aagtaagcgg agaacggacg taagtacgga
    10741 agaaagaggt tttatatgaa caattatcag agtattccat ttaaagacga agatggaaaa
    10801 gaaaaggagt tctatgtcct cgaacagaca actctgaatg gatttcacta tctgttagta
    10861 gaagacggaa gtgcagatgc agatgacgag gaggttgaag ttcttatcat gaaaagagtt
    10921 gctgatgcgg ctgaggatga agaatgggca acctatgaga tggttgaaga cgaggaagaa
    10981 cttatatcag tatccaaagt atttgagcag ttaatggacg atattaattt tgaagtagaa
    11041 tagcaggcag gctttcgtgt gagataaaac ggcagatatt tggcaggaat agatgtccgt
    11101 tttattctat gcgattgtgc tttctgctat atagacaagt gaatagtaga acggaggtta
    11161 gaatttgaaa gtaacaggaa atcaatcagt aaagataata cctctcggcg gattagagca
    11221 gatcggtatg aatattactg cgtttgagta tgaggacagt attattgtag tagactgtgg
    11281 tctggctttt ccggacgatg agatgttggg aatcgattta gttataccgg atatcactta
    11341 tttgaaagag aatgcctcaa aggtaaaggg acttgtaatt acccacggac acgaggatca
    11401 tattggtgcg attccctatg ctcttaaaga actgaatatg cctatttatg caacaaagct
    11461 tacaatggga cttattgaga ataagttaaa agagcataat cttttaagaa caaccagaag
    11521 aaaggtcatc aaacatggcc agtctattaa tctgggaaga tttcgtatag aatttattaa
    11581 aacgaaccac agtatcagtg atgcggcagc actcgctatt tatacaccag cagggattat
    11641 tgtgcatact ggtgacttta agatcgatta cacaccggta tttggagatg ccattgatct
    11701 tggtcgtttt gcagaacttg gaaagaaagg tgttcttgcc ttaatgtgtg agagtaccaa
    11761 tgtagagcgt gagggatata cgccatccga gaggaccgtt ggacgaactc tccgacacct
    11821 ttttgatgag aataaagacc acagaattat tgtagcgaca tttgcttcga acgtagatcg
    11881 tgtacagcag attattgact gtgcgtatag ttgtggaaag aaggttgtta tcgagggaag
    11941 aagtatggtc agcacaatct ctactgcagc agagcttggc tatattaaga ttccagataa
    12001 cacattgatc gatatagaac agatgaagaa ttatgtggat gagcagctcg tgcttataac
    12061 aacaggaagc cagggagaaa cgatggcagc attaagccgt atggcagctt ccactcaccg
    12121 caaggtttct attaagccag gtgatgtaat tatcttcagt tctcatccaa ttcctggtaa
    12181 tgagaaggct gtatcaaaag taatgaatga gcttgccaag aagggagcca gcgttatttt
    12241 ccaggatact cacgtttccg gacatgcgtg tcaggaagag attaagctta tctacacatt
    12301 gacaaagcca cagtatgcga ttccagttca tggagagtac cgtcacttaa agagacataa
    12361 agatcttgcc attgagatgg gtattccaaa agaaaatgta atgatcttac agtctggcga
    12421 tgtgcttacc atttcaaaag agcaggcaaa agttaccggg catgtacctg cacagggtat
    12481 tttagtagat ggtcttggtg ttggtgatgt tggtaatatt gtacttcgtg accgccagca
    12541 tttatcacag aacggcttat ttattgtcgt tgttacactt gaccgttata atggggttct
    12601 tctggcaggg ccagacattg tgtcaagagg tttcgtttat gtaagagaga gcgagaagct
    12661 catggaagag gcaaagagtg ttgtcacgaa cacattagag cattgtaact cgaagaagat
    12721 tacggattgg ggacgtatta agggggcaat ccgtgatgat ttaggagatt atatctggaa
    12781 gaagatgaag agaagtccga tgattcttcc gattattatg gaagtataga caatgatgga
    12841 tgaaggaaag ttatcaatac cgttctttcc tgatacagaa gatattcgtc agggtacaaa
    12901 gaagttgaca gatatgattt gtcatacaga agattacaaa tgttatcaga aagacctgac
    12961 tgttttgaaa gaacaggaag aattatatcg taagtttaaa gaatttcgtg gaaaaagttt
    13021 gtatttacag cttgaaaaag gacaggaaca atactttgaa aaaatagaat cacttcattc
    13081 agagtataaa gatgtgctga cagaaccagt tgtggtagac tttctttccg cagagcagcg
    13141 gatgtgtaaa ctgatgcggc tggtatatga tggtattgca gagaatatta agctggattt
    13201 atcttatatg gatgaactat gattacaagt catatcggat tattcagatt tcgtaaatta
    13261 cagactattt gcagaacaaa aaatgtcaga cgtgagatga acattcattt tggttttacg
    13321 aatgattaac tatggattaa aataaagata aattgacagc ttggatttgg ataaagagca
    13381 taagttatat tagagcgtgt tattaacacg ctctaggata aaaggagtga aaaacatggc
    13441 agagaaagta ttacatgtaa ttatcaaaat attaatgtat atctttatag tacttctttt
    13501 tatcctgctc tttgtgcgga tgagcggagt tggccgtgct atttttgcag ataagccaaa
    13561 ggataagaac ccgcagatag ccagcgagac tgtacttgtc gtagagcagg gggaatctct
    13621 tcttgagatt tctaaagatt tggcagaaca ggggattgta aagaatccgt atctgtttgc
    13681 catatctctt cgctgcatgg atggatatca gaatatccga ccaggggaat atcaggtttc
    13741 ctcttctgag aagccatcag aaatattaaa acagctaaca catgaggagg aaaaaataca
    13801 gtgattacag aagaaagagt tctggatttc attcgttcct ttggagtaga cagaggttct
    13861 gaggctttgc atatgataga aaaagaagcc atcagagatg atgtgccgat tatccgcaaa
    13921 gagtcagggg aacttcttcg aatattgctg caaattaaaa aaccggagaa aattctggag
    13981 gtaggtgctg ccataggatt ttcttcggtt tttatgggtg aaaatacaga taacaataca
    14041 cacattacga caattgaaaa ttatccgccg cgtattgagc gggcaaaagt aaatatcgca
    14101 cttgccggaa tggaagataa gattacgtta atttcgggag atgcggcaga agtgttgaaa
    14161 gaactttccg gaagctggga ttttattttt atggatgcgg cgaagggaca gtatattcac
    14221 tttatgccgg aagtaatgcg gcttctggcc ccgggaggaa ttttagtctc ggacaatgtt
    14281 ttgcaggatg gagatatttt tgaatcccgt tatgggatta agagaagaaa tcatacgatt
    14341 cataatcgca tgagagagta tttatatgca ttgacacatg atgaagcgct tgataccgtg
    14401 attttagaaa caggagatgg catggcaatc agtgtgaaaa aagaatgaga agaaagaaag
    14461 ggataagatg agaaatacag aattactcat accggcgagt agcttagaag tattaaaaac
    14521 agcagtactt tacggtgcag atgccgtata tatcggtggg gaaatgtacg gacttcgtgc
    14581 aaaggcccgc aatttttcca gagaagatat ggaggcaggc gtaaagtttg ctcatgaaaa
    14641 tggagtaaaa gtatacgtta cagctaatat tgtggcgcat aatgaagact tagagggaat
    14701 cagagagtac ttcagggaat taaaagaaat tggcccagat gccctgatta tttctgaccc
    14761 tggcgtattt atgattgcca gggaagaatg tccagacatt gagcgtcata tcagtacaca
    14821 ggcaaacagt acaaactacg caacttataa tttctggtac gcacagggag caagccgagt
    14881 tgtggcagct cgtgagcttt ctttagcaga actttctgag attcgtgcca acattccaga
    14941 agatatggaa atcgaagctt ttgttcacgg tgcaatgtgc atttcccatt ccggaagatg
    15001 ccttctcagt aattatttta ctggaagaaa tgcaaacatg ggagcttgta cacatccttg
    15061 ccgctggaaa tactatgtca tggaggaaag ccgtccgggc gaatatcttc cagtagagga
    15121 aaatgagcgc ggcacataca ttttcaattc caaaga
//
