GCA_003466725.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaFDDPCKPB_1 (original name was: gnl|Prokka|FDDPCKPB_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	HR-T2PKS,NRPS,NRPS-like	285,763	371,268	leucomycin	Polyketide	3%

gnlProkkaFDDPCKPB_10 (original name was: gnl|Prokka|FDDPCKPB_10)

Region	Type	From	To	Most similar known cluster		Similarity
Region 10.1	cyclic-lactone-autoinducer	1	10,381

gnlProkkaFDDPCKPB_31 (original name was: gnl|Prokka|FDDPCKPB_31)

Region	Type	From	To	Most similar known cluster		Similarity
Region 28.1	ranthipeptide	1,339	22,946
Region 28.2	RRE-containing	123,824	144,087

No secondary metabolite regions were found in these records:: gnlProkkaFDDPCKPB_2 (original name was: gnl|Prokka|FDDPCKPB_2); gnlProkkaFDDPCKPB_3 (original name was: gnl|Prokka|FDDPCKPB_3); gnlProkkaFDDPCKPB_4 (original name was: gnl|Prokka|FDDPCKPB_4); gnlProkkaFDDPCKPB_5 (original name was: gnl|Prokka|FDDPCKPB_5); gnlProkkaFDDPCKPB_6 (original name was: gnl|Prokka|FDDPCKPB_6); gnlProkkaFDDPCKPB_7 (original name was: gnl|Prokka|FDDPCKPB_7); gnlProkkaFDDPCKPB_8 (original name was: gnl|Prokka|FDDPCKPB_8); gnlProkkaFDDPCKPB_9 (original name was: gnl|Prokka|FDDPCKPB_9); gnlProkkaFDDPCKPB_11 (original name was: gnl|Prokka|FDDPCKPB_11); gnlProkkaFDDPCKPB_12 (original name was: gnl|Prokka|FDDPCKPB_12); gnlProkkaFDDPCKPB_13 (original name was: gnl|Prokka|FDDPCKPB_13); gnlProkkaFDDPCKPB_14 (original name was: gnl|Prokka|FDDPCKPB_14); gnlProkkaFDDPCKPB_15 (original name was: gnl|Prokka|FDDPCKPB_15); gnlProkkaFDDPCKPB_16 (original name was: gnl|Prokka|FDDPCKPB_16); gnlProkkaFDDPCKPB_17 (original name was: gnl|Prokka|FDDPCKPB_17); gnlProkkaFDDPCKPB_18 (original name was: gnl|Prokka|FDDPCKPB_18); gnlProkkaFDDPCKPB_19 (original name was: gnl|Prokka|FDDPCKPB_19); gnlProkkaFDDPCKPB_20 (original name was: gnl|Prokka|FDDPCKPB_20); gnlProkkaFDDPCKPB_21 (original name was: gnl|Prokka|FDDPCKPB_21); gnlProkkaFDDPCKPB_22 (original name was: gnl|Prokka|FDDPCKPB_22); gnlProkkaFDDPCKPB_23 (original name was: gnl|Prokka|FDDPCKPB_23); gnlProkkaFDDPCKPB_24 (original name was: gnl|Prokka|FDDPCKPB_24); gnlProkkaFDDPCKPB_25 (original name was: gnl|Prokka|FDDPCKPB_25); gnlProkkaFDDPCKPB_26 (original name was: gnl|Prokka|FDDPCKPB_26); gnlProkkaFDDPCKPB_27 (original name was: gnl|Prokka|FDDPCKPB_27); gnlProkkaFDDPCKPB_32 (original name was: gnl|Prokka|FDDPCKPB_32); gnlProkkaFDDPCKPB_33 (original name was: gnl|Prokka|FDDPCKPB_33); gnlProkkaFDDPCKPB_34 (original name was: gnl|Prokka|FDDPCKPB_34); gnlProkkaFDDPCKPB_35 (original name was: gnl|Prokka|FDDPCKPB_35); gnlProkkaFDDPCKPB_36 (original name was: gnl|Prokka|FDDPCKPB_36)

Compact view

gnlProkkaFDDPCKPB_1 - Region 1 - HR-T2PKS,NRPS,NRPS-like

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Location: 285,763 - 371,268 nt. (total: 85,506 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 285762 - 371268:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 323938 - 371268:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_386

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

ctg1_387

AMP-binding (499..751): X

nrpys: (unknown)

SVM prediction details:

NOTE: uncertain match

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKN-----K
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

gnlProkkaFDDPCKPB_10 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 10,381 nt. (total: 10,381 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFDDPCKPB_31 - Region 1 - ranthipeptide

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Location: 1,339 - 22,946 nt. (total: 21,608 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFDDPCKPB_31 - Region 2 - RRE-containing

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Location: 123,824 - 144,087 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.