LOCUS       c00005_gnlPro..        16194 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDKDDMJP_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:56:18
            Original ID  :: gnl|Prokka|NDKDDMJP_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16194
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16194
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1951:6194]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1952..6194
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..16194
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16194
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(3..335)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MGWQKPDELPVTLSTLMQKAMNDQCIPPGEGVLHHAEGVDLIPAS
                     IELAGLEVALVNTMSREKMLKQVLDSAKQDYDYILLDCTPSLGMLTINALAAADTALIP
                     VQAQYLS"
     CDS             complement(494..1363)
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="MTLDYFYGQTGELFSFYRIPKALFQEQRFQSLSTDAKTLYGILLD
                     RMSLSVKNGWLDKQNRVFILFTIEDVKRALCCADNKATKLLRELEKFGLIERKRRGQGK
                     PSLVYVKNFSAESSKESVKNRDNDDSCGFKIACQDPAKSRCNKTKENDTEMSETNLFYS
                     EESDGMSKRAQLEEYFSQSLEVDLLLRLCPDDEDTIYQIVDLLVDTCATNRKLLHIAGD
                     DKPAEVVRSRFMKLNADHIKFVLKCLAENSSPIRNMKQYLLASLYNAPTTMQLYYQNQT
                     NHDLAKRG"
     CDS             complement(1952..3163)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_3"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 4.1e-14,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEAQLHRLPTPCYLLDEAQLCRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RTDEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     KWLNFGGGHHITRPGYALATLENCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(3163..4422)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_4"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.9e-44, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 6.7e-33,
                     bitscore: 105.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTTTKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             complement(4462..5337)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_5"
                     /sec_met_domain="Arginase (E-value: 1.2e-76, bitscore:
                     250.0, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAIR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGRI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLDAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             complement(5337..6194)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_6"
                     /sec_met_domain="Spermine_synth (E-value: 1.5e-53,
                     bitscore: 173.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.6e-22,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAEAWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             complement(6207..7673)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_7"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.3e-11, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 8.8e-123,
                     bitscore: 401.9, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHQGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             8245..8988
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="MEKEGVGMALPIAIVEDQTPDAQRLEELLQQQLPAAECTWFACGD
                     DFLRAASEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQEEKFEHLAAELRRALRCKEPELEIRIARQSIQLPLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTALENFMSCNRGVIINMDKVLRFGEDCIEILDGTCLPV
                     RQKDKCTLLAHFTQYQFRHMRQELH"
     CDS             9006..10322
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCSVFGLSSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTVLNAQAEISNPQTVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLRQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILRSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEHLFRVNVLLNL"
     CDS             complement(10407..10646)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKNTKKLEK"
     CDS             complement(10666..11142)
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             complement(11556..13079)
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNGITVVKHYIDRA
                     LSAKTDNRPDFQQMIKDSEKRLFDIVLVWKLDRFARNRYDSAHYEYQLERNHVKLVSAT
                     EPISDSPAGIMVKSMLTGMAEYYSAELSEKVVRGMTENVLKGKYNGGTIPIGFKVDEEK
                     FFQIDPLKAPFVVEAFQRYNDGATMKELMNWLNDSGVTTNRNQKFTYNSVQTLLTNKRY
                     IGENHFKDIVMPDSIPAIVDKDLFEEVQLKIKKNSRAPARHKAEDDYLLTTKLFCGMCG
                     AMMFGECGTGRNKVVHHYYKCATAKRFKTCKKKTVRKEWLEDLVIAETMKLIQDDAVID
                     AIVAEVMELQDQENTTLPLLEKQMREVENGIENMLNAIQAGVLTNSTKSRLEKLEAQQK
                     ELEVRIAEEKIARPRLSENQVRFWLTRFRKLDPNVKSHRETLINTFENAVYLYDEKVLI
                     TFNYKDGTKTITFDEIAAKDAPEGNGSDLGCFAPPKSLSVCKCAEVFVL"
     CDS             complement(13093..13413)
                     /locus_tag="ctg5_13"
                     /transl_table=11
                     /translation="MKQYDVKISHAALSDMEQIYSYIADRLLEPDTAMGQYNRIAEAIQ
                     SLNILPERCALVESEPERTQGLRQMLVDNYSVFYIVGEDAVSVARVLYSASDLVRRLRR
                     MK"
     CDS             complement(13410..13715)
                     /locus_tag="ctg5_14"
                     /transl_table=11
                     /translation="MEKTMTLNLRVNPTVKQQAEDVLKQLGIPMATAIDMYLRQITLTG
                     GIPFSLSLPKAPAALNADTMTDDQLHAALQVGIKEIQNGDTVDAASAFAQFREQHR"
     CDS             complement(13953..14162)
                     /locus_tag="ctg5_15"
                     /transl_table=11
                     /translation="MKKILTAIVSVSIFIVGILLILCADTNFLWYAFNQNVRLTVVAGI
                     LIALVGGVGVIMNLWCILKELYSK"
     CDS             complement(14640..15089)
                     /locus_tag="ctg5_16"
                     /transl_table=11
                     /translation="MKRQWSNSSNEAMQMERCAETDDPNLITGRYMDNDSFFLVQYRNG
                     KATEIGIQRDLSKVASIKLFGIDMFNTTAECIIDSLMKKDNVICNEKDLQLGTEYLFPE
                     IGVRLWRERAFHLKLLKDPLYMEEMQAVLEDEYQYQYFQMVTVMG"
ORIGIN
        1 gcagaaagat attgagcctg tacgggtatc aaagcagtgt ctgccgccgc cagcgcgtta
       61 atggtcagca tcccaaggga gggagtgcag tccaacaaaa tatagtcata gtcctgcttt
      121 gcactgtcca agacttgctt cagcattttt tcccggctca tggtattgac aagggcaact
      181 tccagccctg ccagctcaat gctggccggg atgaggtcta caccctctgc atggtgcagc
      241 acaccttcac cgggcggaat gcactggtcg ttcatggctt tctgcatcag ggtagaaaga
      301 gtaacgggca gttcgtccgg cttctgccag cccatactaa tggtgagtga accctgcggg
      361 tcagcgtcta caagtaggac cttcttaccc tcggcggcaa ggccaacacc caggttttca
      421 caggttgttg ttttgccagt gcctcccttt tggttgacaa tggcaatcgt ggttgctttt
      481 ttggaaattt ttatcacccc cgtttcgcta aatcgtggtt ggtctgattc tgatagtaaa
      541 gctgcatggt ggtcggtgcg ttgtacagag aagcgagcag gtattgcttc atgttcctga
      601 ttgggctgct gttctctgca aggcacttca acacaaattt gatgtggtcg gcgttcagct
      661 tcataaatcg gctacgtacc acctcggcgg gcttatcgtc cccggcgatg tgcagcagct
      721 tgcggttggt agcacaggtg tccaccagca aatctacgat ctgatagatg gtgtcctcat
      781 catccgggca gagccggagc agaaggtcta cctccaaaga ctgcgaaaaa tattcttcca
      841 gttgggcgcg cttactcatc ccatccgatt cttcggaata gaagagatta gtctcactca
      901 tttcagtatc attctcttta gtcttattac atcgtgattt tgcagggtct tgacacgcga
      961 ttttgaagcc acaagaatcg tcattatcac gattcttgac actctctttt gaagattctg
     1021 ccgaaaagtt cttcacatac accaaacttg gctttccttg ccctcggcgt tttcgttcaa
     1081 tcagaccaaa cttttcaagt tcccggagca gcttggtcgc cttgttgtct gcgcaacaca
     1141 atgccctctt gacatcctcg attgtgaaga ggatgaacac ccggttctgc ttgtccagcc
     1201 agccgttttt caccgacagg ctcatgcggt ccagcaggat accatacagg gttttggcat
     1261 ccgtggacag gctctggaac cgctgctcct gaaaaagagc ctttggaatg cggtagaagg
     1321 agaaaagctc tccagtctgt ccgtagaagt agtcaagggt catgcggttg gtccatggat
     1381 aaaaaacagc aaaaatacat cgacatcgtt gagaaaacct ccttgtcaat atttttgggg
     1441 aaaataaaaa gcgcaacttt gatgtgtaaa atcaaaattg cactaagtaa gctgtcagaa
     1501 aaaacttttc tcgtaaatga ccttcgctct gagcaaaacc cattgacaca cttaaaaatt
     1561 gggtggtaaa attgccttgt aggcggagca tgattcctgg aagcaggatg cagctgtgaa
     1621 cctttttggc agatagaacg tatcaacgcg atattaagcc cgtccccaca ctttcgtgtg
     1681 ggggtgtgtt tcgataccgt tcgggagagc gcttgcatgg catgcaagag gtcaccggtt
     1741 cgatcccggt aatctccacc agaaacaaaa agcactacac agaaatgtgt ggtgcttttt
     1801 ttgacgccaa acgagtgagg gtttagctca cccaggagag tgccgtgcat ggactgcaag
     1861 agggtcaccg tgattacagc agcccggcaa tctccaccag aacaaaaaag cgtttgtcgc
     1921 agcccgcagg ccgtgacaaa cgctttttat tttactgtgc gcccaagcgc attttgaagt
     1981 cctgatagcc gaagtgcacc agttccctgc aattgccgtc tgcgcccagc agccagatgg
     2041 gcggcagggg catcccgttg aaggtgttgt tcttgcaggt ggtgtagatg gccatatcgc
     2101 cgaagatgag cttatcaccc tcagcaaggg gggcgtcaaa gctgtaatcc ccgatgatat
     2161 cccccgcaag gcaggtgggg ccgcccaagc ggacagtgtg cgctttctcc cccgcctcac
     2221 cggcatccaa cagcggcggg cggtagggca tctcgatgac atccggggtg tggcaggctg
     2281 cggacatatc cagaatggca aggctggtat ccccgttgcg cagggtgtcc agcacggtgg
     2341 taaccagata gcctgcattc agcgcccaag cctcgccggg ctccagatac acctgtacgc
     2401 cgtacttctg ccgcaccgag aggatgcagt tttccagcgt agcaagggca tagcccgggc
     2461 gggtgatatg gtgccccccg ccgaagttga gccatttcat tctgggcagc aggtctgcaa
     2521 actttttctc cactgcggcc agcgttaccg ccagcgcatc ggcgtcctgc tcgcacaggg
     2581 tatggaagtg cagaccgtcc agcagggcgg gcagctccgg gtgcgccgcc acagcagcgt
     2641 cccactgagc acgggtggtg cccagacggc tgccgggtgc gcaggggtcg taaatttcgt
     2701 gcccctcctg cgtggagcac tccgggttga tgcgcagacc gatgcttttg cccgctgcct
     2761 ttgccgccgg gccgaacttt gccagctggc tgggcgagtt gaacacgatg tggtcggcgt
     2821 attgcagcaa ttcctcaaac tcatctgtcc ggtaggcggc gcagaacaca tggttctcct
     2881 tctccggcag ctcttccctg cccaagcggc tctcgtacag gccgctggcc tcggtacctg
     2941 ccagataggg tgccagcacc gggtagacgt taaagttgga aaaagccttc tgcgccagca
     3001 ggatgcggca gccggtgcgc tgctgcacgc ccagcaggat ctcgccgttg cggcacagtt
     3061 gggcttcgtc cagcagatag cagggggtgg gcaggcggtg cagctgcgcc tcggacaggt
     3121 ttgccagccc cgcaaagggc gggcggctgt cgcgcacccg catcagtcca ccagagccgg
     3181 gttatggctc tcggagcggg gcaagccgta cttatccagt gcatccagat acggatcggg
     3241 atcaaactct tctacggtgt gcacgccctt ggtggtccac ttgccggtga gcagcatcag
     3301 ggcaccacac atagccggca cgccggtggt gtaactgatg gcctgactgc ccacttcttt
     3361 gtagcactcc tgatggtcac agacgttgta gatgtagtag gtcttatcct taccgtcctt
     3421 tttgccggta aagatgcagc cgatgttggt cttgccctta gtgcgggggc caaggctggc
     3481 ggggtccggc agcagagcct tgaggaactg gatgggcacg atctcctgtc cgttgaagtt
     3541 gacgggggtg gtggacagca tgcccacgtc ctccagacag cgcatgtggt ccagatagct
     3601 ctggccaaag gtcatgaaga agcggatgcg ctttgcctcc gggatgttct ttgccagaga
     3661 ctcgatctcc tcatggtgca gcagatacat atccttgtcg cccacctgat cgaagttgta
     3721 ctcccgcttg atgctcatgg ccgggatctc tacccagtgg ccgttctccc agtagctgcc
     3781 gggtgcggac acctcgcgca ggttgatctc ggggttaaag ttggtggcaa aggcatagcc
     3841 gtggtcgccg ccgttgcagt ccagaatgtc gatagtgtca atggtatcga actcatgctt
     3901 tttggcgtag gcacagtaag cctgggtcac gcccgggtcg aagccgctgc ccagcagagc
     3961 ggtcaggccg gcttcctcaa actttttggc gtaagcccac tgccagctgt aatcaaagta
     4021 ggcagagaag ccggcttcct tgcagcgctt ctcgtagatg gcgcgccact ccggatcgtc
     4081 ggtgttctcg ggctcatagt tggcagtgtc catgtagttg acgccacagg caaggcaggc
     4141 gtccatgatg gtcagatcct gataaggcag ggcgatgttc atcacgaggt cgggctggta
     4201 ggccttgatg agggcgatga cctcctccac cttgtctgcg tccacctgtg cggtggtgat
     4261 cttggtagta gtggtgggag ccagctcagc agccagttta tcgcactttg ccttggtacg
     4321 gctggcgatg cagatctcgg tgaacacctc gggcacctgg cagcacttat ggatggcaac
     4381 agaggccacg ccgccgcagc cgatgatcag aactttgctc atgtcggtta ctcctttatc
     4441 tgtaaaatgg taggttcgta tttatacctg aaaacccggc cagcccttgt ccagcgcgat
     4501 cagggtctcg cgcagcacct tgcaggcggt ggcggtggaa acgccggtgg tgtccagcgt
     4561 gggggccagc tcgttcaggt ctgcgccgat gatgttggcc ttggtcacag tgcggatggc
     4621 atccagcagc tgcaaaaagc ttacgccgcc agcttccggg gtaccggtac ccgggaagca
     4681 ggaggggtca agacagtcca gatcgatggt caggtacacc ggcaccttgc tctcgcacag
     4741 ctgtgcggtc agttcggcaa ggccggtaaa atcaaacttg tgcatctcgg tgtgctgggc
     4801 agcaaactca aactctgccc ggtcgccgct gcggatgcag aactgatgga tgcggccgtc
     4861 ccctaccagc tcgtggcagc ggcgcagcac acaagcgtgg ctgagcttcg cgcccagata
     4921 gtcgtcccgc aggtcggcgt gggcgtcgaa atggacgatg tgcaggtcgg ggtatttctt
     4981 caccgcagcc cgcacggcac ccagtgtgac cagatgctca ccgcccagca gcagcgggaa
     5041 cttgccgtcc ttcaaaatct cctctgcccg ggcctcgata tcggccagtg ccagctcgct
     5101 ggagccaaag cacagctcca gatcgccgct gtcgaacacg tcaaaatcgg tcaggtcggc
     5161 gttctggtag gggctgtaag tctccagacc gtagctctcg tgccggatgg ccgccgggcc
     5221 gaaccgtgct ccggggcggt agctggtggt ggaatcgtaa ggcgcaccgt acagcacgat
     5281 gctggcggcg cggtagctgc tgtcgcagcc gataaaggtc tcaacgttgg ggtgcatcag
     5341 tgttcctcca cttcccgcag catctcctcc agaaaagccg gcaggtaaaa tgctccgata
     5401 tgcagtttgg tggtatagta gcgggtgcgc atattcagcg ccttccacgc ttctgcgtcc
     5461 agatcatcaa tgggatggta ttttttgctt gcaaagccga acagccagta gcccgccgca
     5521 aaggtaggga tatgtgcctg atacacccgg ctgatgggga aggtggatgc aatgcgcttg
     5581 tggctgcgct gcatggcact ggcatcttcg gcgtagaagg gactgccctg ctggttgacc
     5641 atgatgccgt cctctttcag ggcgttgaag cagctgccgt agaactcgcg ggtgaacaga
     5701 ccctcagagg ggccgaaggg gtcggaggag tccacgatga tgaggtcgta ctcctcctcg
     5761 cagcggcgga tatacttcag ggcattctca aaatagatat gcacccgacg gtcatccata
     5821 cggcaggcat tgccgggcag ataggcgcgg caagcctcca ccacctgtgg gtccatctcc
     5881 acaaggtcga tgcgctccac gcggtcgtag cgggtcagct cccgcaccac gccgccgtct
     5941 ccggcgccga tgaccagaat atccttggcc tccttgtgca ccgccatggg cacatggacg
     6001 atcatttcat cgtagatgaa ctcgtcgcgc tcggtcagca tcacgttgcc gtccagcgtg
     6061 agcacccggc cgaactccgg ggtctcaaag atatcgatgc gctgataatc gctctgcttg
     6121 gagtagagct gcttgtttac acgaatgctg tgcttcacat ccggggtgtg aaactctgaa
     6181 aaccaaaatt ccatctcttt ccctccttat gccagaacat tcaggtgcaa aatttcgggg
     6241 tcctccgggc cggtcatgct gcagcccttg gccttggcgt actcgatgta gttcaagatc
     6301 tccttggtga tgcgctcgcc gggtgcaagg atggggatgc ccgggggata gcacatgacg
     6361 aactcgctgc acaccatgcc ctcggtctcc cgcaggggca ggctcttttt gggggcgtag
     6421 aaagcctcct gcgggctggc agccaccaca gggtcgatgt attcctgact cagcagcccc
     6481 gagccgtcgg tgcggtagcg gcgcttgatc tccgccagcg cactgaccag acgctccacc
     6541 tcctgcgggc ggtcgccgat ggacaggtag gcaaggatgt tgccgatatc gccgaactcg
     6601 atctgaatgt catactcgtc ccgcaggatg tcgtagacct cgatgccggc aagaccaata
     6661 tccagcgtat ggacgctgag cttggtggtg tcaaagtcaa aaacagaatc gccgttgcac
     6721 agttccttgc caaaggcgta gtagccgcct acggcgttga tttcctcgcg ggcgtactcg
     6781 gcaatgtctg ccacctgatg gaacacctgc cgtccccgca gcgccagatt gcggcgggag
     6841 atatccagac tggacatcag caggtagctg ccggaggtgg tctgggtcag gttgatgatc
     6901 tgacgcacat agccctggtg cacgttgggg ccaatgagca gcaggctgga ctgggtcagg
     6961 ctgccgccgc ttttgtgcat ggacaccgag gccatgtcgg ctccggctgc catggcggac
     7021 accggcaggc cgccgccaaa gtagaagtgg gtgccgtggg cttcatccgc aaggcagagc
     7081 atcccggcgt cgtgcgccat ttttacgatg gcacgcaggt cagagcagat gccgtagtag
     7141 gtggggttat tcaccagcac agccacagcg ttggggtgct ccttgatggc cttggccacc
     7201 tgctccctct tcatgcccag cgagatgccc aggcgcttat ccacctccgg gttcacatac
     7261 accggcaccg cgccgcacag caccagcgcg ttcagcacgc tgcggtgcac gttgcggggc
     7321 agaatgatct catcgccccg cttgcaggcg gtaagcacca tgctctgcac gctgctggtg
     7381 gtgccgccta ccattaaaaa ggcgtgtgct gcgccaaagg catcggcggc aagctcctca
     7441 gcttcccgga tgaccgacac cgggtggcaa aggttatcca gcggcttcat actgttcacg
     7501 tccacgccca cgcactgctg acccagaaaa gcggtcagct ccgggttgcc gcggcctcgc
     7561 ttgtggccgg gcacgtcaaa aggcaccacc cgcatctgcc ggaaccgctc cagcgcctcg
     7621 taaatgggcg cacggcgctg atccagccgg gaacgcgctt tgttttcgtt catcttttcc
     7681 tccgtccctg ttcttctttt tgcacaacaa aaaagcgcag acactgcaca aatgtgcaga
     7741 cctgcgcttg gagcagcttt ttccgcgctg ataaagcacc cagccgtaag tgccggtgct
     7801 gcgcgttatt cgcgatccaa aaagacgggg tgatgagagt ctatatagca actacacttt
     7861 tactactctt attgaccgtt tcacaagtct gcgcataggc tgcgcaattt catggttgta
     7921 aaggaaccaa cttataaaat ttgagcttca aactcaatca ataatggcag cttgcgccgc
     7981 cggtcggcag tggacccggc tgtccgtatg gccttagccc cgtttgggcg gtcccgagta
     8041 aattgctttg aaaagactct gcaaggcggc gtctctcaaa atcaacaaaa gaataacatg
     8101 attcgccccg tctgtcaacc aaaacttttt gacagtcgcc cgctgcgggt gcgcagggcg
     8161 gcgctcggcg cgcaaaatgg ggcgttttgt gcaaaaaagc agatgccctt cccgccgcag
     8221 tatgctataa taaaggaaca atgaatggag aaagagggtg tagggatggc actgccaatc
     8281 gccatcgtag aggatcagac cccggacgcc cagcggctgg aggagttgct gcaacagcag
     8341 ctgcctgcag ctgagtgcac atggtttgcc tgcggggatg attttctccg cgccgcatca
     8401 gagcccggcc tgtacgccgt ggtgtttctg gatatctgca tggcgggcac caatggcatc
     8461 gagaccgccc gccgactgcg gcaggccgac ccggaggtgc tgatcgtatt cgtgacctcc
     8521 tcgccggaat atgtatggga tgcctttccg gtgcacccct tcgattacct gctcaaacct
     8581 tatcaggagg aaaaattcga gcatcttgct gctgagctgc ggcgggcgct tcgttgtaag
     8641 gagccggaac tggagattcg cattgcccgc cagagcattc aactgccgct gcgcaaggtg
     8701 ctgtacgcca ttgcccggaa ccactacgtc cttatcacca ccgaggatgg cgagtaccgc
     8761 gccatgtgca gttttgcgca gatcgaagaa aagcttactg ctctggaaaa ctttatgagc
     8821 tgcaaccggg gcgttatcat caacatggac aaggtgctgc ggttcgggga ggactgcatc
     8881 gagatcttgg acggcacctg cctgccggta cggcagaagg ataaatgcac cctgcttgcc
     8941 cactttacac aataccagtt ccgccacatg cggcaggagc tgcactgagg aaaggagcag
     9001 ccgccatgga tcttgccctg ttcggccgtt attttctgga ttttgcgctg ctgtatccca
     9061 gcgcgtttct gtgtctggca tccctatggg aaaagctgcg cacccccagg cgcaccgcct
     9121 gcatcgctgc cggatgcatt accctgctgt gcatcggctg cgccgcactt tgctccgtgt
     9181 tcgggctgag cagcaattct ctcctgcccg ccatcgtgct ggtctccttc tggctgctgc
     9241 gctggcgggt aacgccggaa gtgaccgtaa gccagaccgc gtttctgttt tccatctctg
     9301 ccgtgatgat ggcggtgtgt tccctgctgt cgacggtgct caacgcccag gccgagatct
     9361 ccaacccaca gacggtctgc cttgcctcca cggcgctgct gcggctgggc cttgctgcga
     9421 tgctcaccgt gctgttctgg ttcaccgccg tgcagtggag ccggtggctg ctgcgggagt
     9481 acagcggtga agccttctgg cagtctgcgt ggccgctgcc cgccctctat gccgtttttc
     9541 tggtatactg tatgccgctg aaccccgccg tggtgctggt cgggcggctg aagatcatct
     9601 cggtgctggc ggtgtccatc tcgctgttcg gcatctttct gctgctgtac gagatgtacc
     9661 gcgttgcccg ggagttcacc cgcaacgccc ggctggaccg ggaaaaccag ctgctggcca
     9721 tggaatcccg ccggtacatg gagttacaga cctatctgga caacacccgc cgtctgcggc
     9781 acgacttccg gcagcatctg catgtgattg ccggactgac tgagaccggg cagctggagg
     9841 agctgaaaag ctatctgcgc cagtacgaaa gcgagctcag cgagcaccgt cccagcctgt
     9901 gcgccaatgc cgccgtggat gcactggccg gatattacga ccatgcagcc gggcagcaga
     9961 gcgttcctgt ggagtggaag ctggcactgc ctcggcagct tcccatgccg gaggccgacc
    10021 tgtgcaccat tctgggcaat ctgctggaaa acgccctgca cgccagtcag aagctgccgc
    10081 cggagcagcg ccgggttcag gtgatggcgc agatgctcag tcccgccatg ctggggcttg
    10141 tggtggagaa ccgttacgac ggcatgctga aaaagcagca gggtatcctg cgctccacca
    10201 agcacgaggg caccggcatc gggctggtat ctgccgagac ggtagtgcac aaatataacg
    10261 gcaatctgca tctggagacc gaggaacacc tcttccgggt gaatgtcctg ctgaatctgt
    10321 agccaccggc agaccaacgt gaaagcgttt acaaaaagca gcgccgtcct ttgcagaagg
    10381 ttttttctgc gaagggcggc gctgtattat ttttcaagct tcttcgtgtt tttttgtgca
    10441 gcttccagtt catccacccg cttttgcagg gcggtgatct tatcgtccat tttcaaaaat
    10501 gtccagacca gaacagccag caccagcgcg ggaggaacga ccatccacag ggactgctga
    10561 caccagagca gcagcgaata gccgccgaat acagtaaaaa taaatacggc aaacagactt
    10621 gcagccagta cagcaaaaaa tcccatacag aaagtctcct ttcagttatt cttccgtttc
    10681 ttcctcgtcc gggtccagct caatgctgaa cacggctttt ttcagcttgc cgcagccctg
    10741 cgccttcaga ccggatttat acggttcccc cgccagatac agggcaaagc gtccctcgca
    10801 cagcatcccg gcaatgctgg taccggcagt gcctacggtg gtgtcggcag cttcatcggt
    10861 gggcttggtg ggcgtcagct ccgcaaggct tacctcaaac agctcgctgc cgtctaagtc
    10921 agtctccagc gtgatgtgat tgtcgtggcg ctggaacagt gccttgtcgg aggtctgggg
    10981 cgtgacagtg ctcacggtga ccaccgcctt gtctccatca atgcgggtgc gcccggcagg
    11041 aagggtggtg atatcccgcg ccatgatgta ctcgatcacg gtgtccagat tatcgcttac
    11101 gcccagatag ttgggcaggt tgttcagggt atcgtagatc atagaaaaag tcctccgtct
    11161 gtgttgtttc agttacctgt atggtatcac aggtcaggga cagatgcaat atgtgtgcgg
    11221 gcagatgtcg cgagccgcgc agaaaaggaa cctgggtcgc ggctcccagc ggctgcacca
    11281 tgccttgggc ggcacgcgca tcctgctggc cgcagccaca acagttcctc cctgtttctg
    11341 ccgctggcag cggtcgtcgc tgttgcacag gggctttttc cccgccggac tattcggcgg
    11401 gtcttacgag ttgcgcttgc cggctttttc cgcagcccct tggcagggct ttgaaaaagc
    11461 ggagcgctgc cccaccctcg cctccctgtt tccgccgcag gcggcggtcg gctccgctgc
    11521 tgttcgaatc cacccgctct atgagtttag ccttgtcaca aaacaaaaac ctcagcgcac
    11581 ttgcatacgc tgaggctttt tggtggagcg aagcaaccca aatccgaacc attgccctct
    11641 ggggcatctt tggcggcgat ttcatcgaaa gtgatggttt ttgtgccgtc tttgtagttg
    11701 aatgtaatca aaactttttc atcatagaga taaacagcgt tctcaaacgt attgataagc
    11761 gtctcacggt ggcttttcac gttcgggtcg agcttgcgga accgggtcag ccagaaccga
    11821 acctgatttt cactcaaccg aggccgagcg attttttctt cggcgatccg aacttcaagt
    11881 tctttctgct gggcttccag cttttccaaa cgcgatttag tggagtttgt cagcacacct
    11941 gcttggatgg cgttcagcat attctcaatg ccgttctcca cctcgcgcat ctgcttttcc
    12001 agcaaaggaa gcgtggtgtt ttcctgatcc tgcaactcca tgacttctgc aacgatggca
    12061 tcaatcacgg catcgtcctg aatcagcttc atggtttcag ctatgaccaa atcttccagc
    12121 cactctttac ggacggtctt tttcttgcag gtcttgaaac gcttcgcggt ggcgcactta
    12181 taataatgat gaacgacctt gtttctaccc gtaccgcact cgccgaacat catcgcgccg
    12241 cacattccgc agaacagctt ggtggtgagc aggtaatcgt cctcggcctt gtgacgggca
    12301 ggagcgcggc tgttcttttt gattttcagc tgcacttcct caaacaaatc tttatccacg
    12361 atggccggga tgctgtcggg catcacaatg tccttgaagt ggttttctcc gatgtaacgt
    12421 ttgttcgtca gcagcgtctg aacactgttg taggtgaact tctggttgcg gttggtggtc
    12481 acaccactgt cgttcagcca gttcatcagt tctttcatgg tcgcgccatc gttataccgc
    12541 tgaaaggctt ctaccacaaa gggagctttc agcgggtcga tttgaaagaa cttctcctcg
    12601 tccaccttaa aaccaatggg aatcgtgccg ccgttgtact tccccttcag aacattctcg
    12661 gtcatgccgc gcacaacttt ttcagaaagt tctgccgagt agtattcagc catgccggtg
    12721 agcatactct tgaccatgat acccgcaggg ctgtcagaga taggctccgt ggcagatacc
    12781 agcttgacat gatttcgttc caactggtac tcataatgtg ccgaatcata gcggttccgg
    12841 gcaaaacggt caagcttcca gaccagcaca atgtcaaaca accgtttctc gctgtccttg
    12901 atcatctgct ggaagtccgg acggttatcg gttttggcgg aaagggcgcg gtcaatgtag
    12961 tgcttgacca cggtaatgcc gttcttttcg gcataggctg tacactcgcg aatctgacct
    13021 tcgatggatt cttcacgctg gttgtcgctg gaatagcggg cgtagatcac agcggtcatg
    13081 cgaacacccc tttcacttca ttctccgcag gcggcggaca aggtcggatg cactgtacag
    13141 cacacgcgcc accgacacgg catcctcgcc cacgatgtag aacaccgagt agttatccac
    13201 cagcatctgc cgcagccctt gggtgcgctc cggctcgctt tccaccagcg cacagcgttc
    13261 cggcaggatg ttcaacgact ggatggcttc agcaatgcgg ttatactgcc ccatggccgt
    13321 atcaggctcc aacagacggt cggcaatgta gctgtaaatc tgctccatat cgctgagggc
    13381 tgcatgagaa attttcacgt catattgctt catctgtgct gttccctgaa ctgtgcgaat
    13441 gcgcttgcag catccacggt atcaccgttc tgaatctcct tgatgcctac ctgcaaggct
    13501 gcatgaagct ggtcatcggt catggtgtca gcgttcagag ccgcaggagc cttcggcagg
    13561 gacagcgaga agggaatgcc gccagtcagg gtaatctggc gcaggtacat atcaatggca
    13621 gttgccatcg ggatgccgag ctgcttcaac acatcctcgg cttgctgctt gacggtaggg
    13681 ttgacacgaa gattgagcgt catcgttttt tccatggtta tcacctcagt ctcattgtaa
    13741 cgcattttac gttgcaagtc aattcgaggt gaacgcgcaa atgaaattct ccatatcgca
    13801 caatatattc atcgttaaat tgttcaaagc gcgggatatt caccctctat aataaattct
    13861 tggagtgtgc ctagcttttg ctgagtagta agtttgaata ttatctctct tggctgcgac
    13921 catggcagac tggaagttta accttcaata aactatttac tgtacaattc ttttagaata
    13981 caccaaagat tcattatcac accaacgcca ccaacaagtg caatgagaat ccctgcaact
    14041 actgtaaggc gaacattttg attaaaggca taccataaaa aattagtgtc cgcacaaagt
    14101 ataagcaaaa ttccaacaat aaatatgctt accgatacga ttgctgtaag aatttttttc
    14161 atgttacact ctcctttgtg tatcactgtt attctccgag aaagttcgac tcacatccct
    14221 atgatagtga acacatcatt cgtttcaaaa cactttgctg cccaaggaac tgcttctgca
    14281 ataatctctt tgcaagtaca tccatccgat tgactttttg ttaaaatatt atcccattgt
    14341 acttttgtaa cgattgttat tccataaaag tcaaactctg gaatcacttc aagaatcaga
    14401 tctgaaacat ggcggctatt ccatacttca tcactgatgc taatagatgt gtcaagccag
    14461 cacttgtcat gatactgccc ttgttgaaat tccaaatagc agctgctgtg tgaggctttt
    14521 ctttgatctt cgtcaataaa atacttcaaa ttagttcacc cgtattagca gatagctgtg
    14581 gtcatcgcta tgtaccacaa gcggaaaagt tatatcaaat cccattgatc gttagcaatt
    14641 caacccatca cagtaaccat ctggaagtat tgatactgat attcgtcttc caatacagcc
    14701 tgcatctctt ccatgtataa cgggtctttc aacagtttga gatgaaatgc tcgctctctc
    14761 caaagtcgga ctccaatttc agggaaaaga tattccgttc caagttgcaa gtccttttcg
    14821 ttgcaaataa cgttgtcctt tttcattaag ctatcaataa tacactcggc ggttgtatta
    14881 aacatatcta tcccgaacaa ttttattgat gccactttag acaaatctct ctggatgccg
    14941 atttcagtag cttttccgtt ccgatactgc acaagaaaga acgaatcatt atccatatat
    15001 cgtccggtta tcaaattagg gtcatcggtt tccgcacaac gttccatttg cattgcttca
    15061 ttagaagaat tcgaccattg tctcttcatt tgcagaagag ttttttctag ctcatctggt
    15121 gccataccta attttaattg tccaattcca atatgtggtt caacaattat ctcttccata
    15181 ataattctca aaagcattta tattcatttc attatttagg gcatgaaaat aggattactg
    15241 taaccgaata ctgtatatcg tatcaaactg atatgggtca gataacaaaa cctttccatt
    15301 ggaaactacc acaatctttt cgccttcttc aatttgcgat agttgaatat ttccttttaa
    15361 gcattccgaa actccctgaa tgagatagta atcatttgta ccgtacagtt gattggaagc
    15421 agttgcatag atagaattat tgcttaaatc tacctttgtt acagtaagtt ccgattttgt
    15481 cctcccccac ggatgcaaca ggaaactgcc tataagaatt gctagggcca aagctatacc
    15541 aaagacagcc aattccttac ttgatttcgt cattttaagt acctcttcat catagctcca
    15601 tttgaatttt ctgaacgtca cattttttct gaacgattgc agttataagg atcacatcaa
    15661 tggtatcatg attattggct tctctgtttg aataacgaaa tctaagtcaa gtttatttca
    15721 tctgtctgcg atttttttaa aatcgtatag atgcacataa atttccggaa aacttgtagc
    15781 acaatcacga tttttctttt cattcatgta aaccaccacg gcagttccag ccacaagtta
    15841 tccatggcct gttcctcgat ttttttggcg cggcctttcg tcaggtgaaa gtatatcgcc
    15901 gtgccgatca gcggatgctc ctcgccatcg gtgaagccat agcggtacag cagataggtc
    15961 tgctctcgct gggtcagccg tttcaggcca tcgtacagtt cccggcgcga ttcctgctcc
    16021 tctataatgc tctgcggctg catggcgtag gggtcggcta tggcttcaat gcgccgcagc
    16081 tgctcttctc ccggcagaac atcgtccagc gaaacgcgct ggtaacagac gccgtccttg
    16141 tcctccgtta ccatccgctg ttcaaaagcg gcaaaggcat cccgcaccat gtcc
//
