LOCUS       c00022_gnlPro..        14680 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENOAJIDE_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:19:01
            Original ID  :: gnl|Prokka|ENOAJIDE_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 74815
            Orig. end    :: 89495
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14680
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[84815:89027](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..14212)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14680
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14680
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             734..1744
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_63"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.5e-08, bitscore:
                     27.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRINRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
     CDS             1731..2585
                     /locus_tag="ctg22_64"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             2582..3859
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_65"
                     /sec_met_domain="Radical_SAM (E-value: 4.7e-16, bitscore:
                     51.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDNGRICLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             3871..5436
                     /locus_tag="ctg22_66"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKA
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPVQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGMLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKECARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             5673..7037
                     /locus_tag="ctg22_67"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             7078..7626
                     /locus_tag="ctg22_68"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             7750..8628
                     /locus_tag="ctg22_69"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKVHKP"
     CDS             8721..9143
                     /locus_tag="ctg22_70"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(9376..9996)
                     /locus_tag="ctg22_71"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(10001..14212)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_72"
                     /sec_met_domain="HGD-D (E-value: 2.9e-22, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 2.2e-33, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
ORIGIN
        1 ttgttgggat tatgagggtg gcgactgttc tgccttatta cagggaatga ttgaaaataa
       61 ggagaagttc gcacaaatag aaggcttgtt ctggggagat attgagcagg aagaacagga
      121 gatttcatgg attgaacaag ctgatattag tccgctgctc gatgccatgc ctaaattgaa
      181 agatctgaaa atcaaaggaa ccaataatct gcgtttggga aagacttcac ggccggagtt
      241 gcggtcactc gaaattatca gtggtggcct gcctaccgaa gtggtagaag atattcttgg
      301 ttctgatttc cccaatctgg aaaaactgat tctatatgtt ggtgtggaag attatggatt
      361 tgaagctgat attgagatat tccgtccgtt gttctccaaa gaacgtttcc cgaagctgac
      421 ttatctgggg atcgtcaact ctgaagaaca ggacaagatt gtagaaatgt tcctggagtc
      481 ggatattctt ccccaacttg aaacaatgga tgtttcggct ggtactctca aagatgaagg
      541 tgcccaatta ttgctggata atatggataa gatcgctcat ttgaagttta tcaatatgcg
      601 ctataattat ttgagcaagg agatgaagaa acagttgcag agtctcccta tgaaaataga
      661 tattgctgaa actgaagagg cagatgaata tgatggtgaa ttgtggtatt acccgatgat
      721 tacagaatag gagatgcaga taatcgttgt cagcaactct ctgtccaaac gtatagaata
      781 ctttattgaa gcaggcaaac acttgcaggt ggaagttcgt tttatgactt acggggaact
      841 ttttaactgc ttgccgcaac tacggcaggc agttatcaaa ctggaacctt gtgtaagcga
      901 tgaaacgaat ttcctgaaat atgcgctgtt gaatcaggca tataaggaga cactgcaacg
      961 tttaggcgag atgaggctat ctgatgacgt gtgctttttg aatactcccc atgctttatt
     1021 acgtgctctt gataaaaagg aaactaaaca agtgttgatg gacagagggt tgaaagtgac
     1081 tccgatgtta ccttctcccc gttcttttga tgagttgaga gagcttcttg ccgattgcgg
     1141 tagaggatgc tttttgaaac cccgttacgg ttcgggggcg ggaggtatta tggctgttcg
     1201 ctatcaaccc aaccggaata aatgggtagt ctatactacc ttgcaacaag tggatggagt
     1261 cattcataac actaaacgta tcaaccgttt gagtacggaa aaagagatga tcccgttggc
     1321 ggaagctgtg atgcaaacag aagctatttt agaagaatgg attcctaaag agcagttgca
     1381 gggagagaat tatgatcttc gtgtagtgtg ccgggaatct gaaattgatt atatcgttgt
     1441 gagatgcagt aaaggaagca taaccaatct gcatctgaac aataaggcac attggtggaa
     1501 cgaattgtct ttgccggaag tagtgcggca acaaatctat tttcagtgtc aggaagcggt
     1561 tcaatctttg gatttgcaat atgccggagt ggatgtactg atagagagag gaacagatat
     1621 tccttatata atagaagtca acggacaggg agatcatgtg tatcaggata tgtttgctca
     1681 taattctatt tatattcaac agataaaaaa cataaaaaag agatataacc atgcaaatag
     1741 atgaactgcc ggctggcgaa cagacccaaa atccggatct ggatatgaat caggtggtgg
     1801 gtactcatga tatattgatg ctttgctttg ataccttgcg ttatgatgtc agcaaggagg
     1861 aagaagaggc aggaagaaca ccggtactga acagtcacgg aggagaatgg gaaaaaagac
     1921 atgcgccggg aaattttact tacccgtctc attttgccat ctttgcagga tttctgcctt
     1981 ctccggcgga acctcattcg ctacgcagcc gtaagtggtt gtttttccct gtgcaagctg
     2041 gtacgggacg tattccgcct gcgggaagtt atccgtttac ggaagcaact tttgtgcaaa
     2101 gccttgccaa tgtaggctat gaaacgattt gtataggagg ggtgaacttc ttcagcaagc
     2161 gtaatgaact ggggcgtgtg tttcccggtt actttactaa aagttattgg ctgccgacct
     2221 ttggatgcac ggcacccgat agtactgaaa aacaaattga ttttgcattg aagaaactcg
     2281 aaaactatcc ggaggacaaa cggattttta tgtatatcaa tttttctgct attcattatc
     2341 cgaactgtca ttatgtggaa ggcaaaatga aggatgataa ggaatcacac gctgccgcgc
     2401 tgcaatatgt cgacagtcag ctaccccgtt tatttcaggc ctttcagaag cggggaaata
     2461 cgctggtgat tgctctttcc gatcatggca cttgctatgg agaggatgga tatgaatatc
     2521 attgcatatc tcacgaaacg gtttatacag tcccttacaa acactttatt ttaacgaaaa
     2581 aatgaatcaa ccgctaccac gatatgtaga ctatatgtat agttatccac ataaaactgc
     2641 ttatcgttct tttccgtccc cggtttcgct ggttccttac ctgaaacagg tggaaggaca
     2701 gaaagcatcg ctttatttcc atattccttt ttgtagtcat aaatgtggat attgcaacct
     2761 gttttctctg caaacaaatc gtgcggatta tatcgcaact tatttggaaa ctcttcacaa
     2821 gcaggcgcaa cagttgtctc cactcactac cggactggca tttgatagtt tcgccattgg
     2881 aggaggcaca ccgttgctcc tcactgttcc tcaactggaa tacctattgg atacggctgc
     2941 cttattcgga gtgcatcctt cacatacctt tacttccgta gaaacatcgc cggaatatgc
     3001 cgatcctacc cgtttggact tgttgaagca agcaggagta gctcgtgtga gtattggcgt
     3061 acagagtttc cttgacgaag aattaacagc tttgaaaaga cgtccccggc gagacatgat
     3121 taatcaggcg ctggaggcta ttcggaagag acaattcccg ttttttaata ttgatttgat
     3181 ttacggaatc agaggacaaa ctgtggccag ctttctttat tcattggaac aggctcttct
     3241 gtttcagcct aacgaactct ttatctatcc gctatatgta cgaccgggaa cggctatcac
     3301 ggagcgggaa tccgacgatg tctgttttca gatgtattgt gccgcttgtg atttgttgaa
     3361 agacagaggt tttctacaaa cgtcgatgcg acgttttatt catcatccgt ctactgatgc
     3421 ggaaatctca tgtggggatg aagtgatgct gtcgtgtggc tccggcggac gcagttacct
     3481 gggtaatttg cattatgcca cccggtatac tgtttgccag cgttgtattg ccggagagat
     3541 agatgattat atgggcacta ctgattttac agtggctcgt aatggattta ttctttctca
     3601 ggaagaacgg cgacaacgtt tcatcattaa aaatctgatg tattatatgg ggcttgataa
     3661 ggccgaatat aagcgtcgct ttggagaatc accggataat gtgatgttgt ttcgacagtt
     3721 agctgaacgg caatggatag aaaatacgga taacggtcgt atttgtctga cttccgacgg
     3781 aatggcatac tccgattata ttggtcagtt gttcattact cctgaaataa gagaactgat
     3841 ggaaacttat tcttattgaa cgaaatagaa atggaaaacg aaagctcttt actttccttc
     3901 aggcatatat attatcgcgg caaattgaat agctgcaact atacctgttc ttattgtcct
     3961 ttcggcaaga agtcgcatct ggcagatacg acacaggatg aacaggcatg gaatcgtttt
     4021 atagcagcta ttgaacaatg gaaaggggag ccgttgcagt tatttattat tccttacggt
     4081 gaagtattga tccatcgtta ttatcggaaa ggaatggtgc atttggcggc attgccacag
     4141 gtggccggaa tttcctgtca gactaacctt tcttttccgg ctaaacactg gcttgatgag
     4201 attcgtgtgg ctcccactgt gataagtaag ataaggcttt gggctagttt tcatcctgag
     4261 atgacttcgg tagagaaatt tgcgcatcag attcatatac tccatcatgc gggaatacag
     4321 gtatgtgtcg gagcggtagg aaatccctct gcaaaggccg tactcaatga tttacggaat
     4381 gctcttttgc cggatattta tttattcatt aatgctatgc aagggttaag ggcaccatta
     4441 agtcaggaag atattcagtt tttcagtcaa ctggataatc tttttgagta tgacttgaag
     4501 aatgctccgg tacaatggga agtttgcgca ggaggaaggg ataattgttt tatcgattgg
     4561 aaaggggata tgtatgcttg tccccgaagc cgggtgaaga taggtaattt ttatcaaggt
     4621 gatggagctg ttgtgccgtt atcttgcaag aggaaggttt gtgactgtta tattgcattt
     4681 agtaacctga acaatcaccc tttacatcga ataatgggag aaggggcatt ctggcgaata
     4741 ccggacaagc cacttattac gactgttttc ttcgatgtgg atggaacact gactgattca
     4801 cagggaaaag ttccagaaag ttatgctaac gctttgcgat atatggcaca gtccgtttcc
     4861 ttatatcttg ccacttctct gtcgatggag caggcgaaga aaaagctggg aaaggctctt
     4921 tttgatttat tcaggggagg agtgtttgca gatggaggtt tattatctta ttcgcggcag
     4981 attaagtgtt tgccggtgaa agtatatccg gaggtatatg gagaatcgtc aaaagttact
     5041 attcatagtt atgaaggagt ggtttacaag tatagtatat tggtacgtga taaagaacag
     5101 agagaatcta ttcttacccg gttgaaagaa aatccctgcc aggtctttca taaagctccg
     5161 ctgataacag tcattcatcc tgaagcgagt aaaaaagagg ggatgcttca gttatgtaag
     5221 gctttgggtt tagcttctga acacacttta gttgtaggaa attcgttaaa ggactggccg
     5281 atgatgtccg tggtttctca ttcttgtgcc gtaatgaatg cggaaccctt attaaaagaa
     5341 tgcgcacgtt atacgctgaa tccggatcgg ttggcagctt tctttcgttt ttctaacgga
     5401 gatcctatag accaaacctc gtctgataat agttgatata tagctagtta catcttcata
     5461 agaaaataaa aaccggttaa aatttggtaa ttatgaaaac aaagcccata tttgcagccc
     5521 tgaaataggg acaggcataa aaatcctcat cggagggtgc tataataata attatagtgc
     5581 tggataagat gaatggtgca aatcattcgc ttgtccggca cttttttttg ttgtaacaaa
     5641 ataagataaa gaggaaaagt atcgaagaaa ctatgaaaga gttagatttg acacaaggaa
     5701 gcgtaccgaa ggtattgttg cagtttgcag taccttttct gattgccaat gtgctccagg
     5761 cactttatgg cggagctgac cttttcgttg tcggacaata tgatgattcg gcaagtgtgg
     5821 cagccgtagc tattggtagt caggtgatgc agacaattac aggtattatt ctgggtatta
     5881 ctaccgggac aacagtgctg attgctattg ctaccggagc taaagacaat cgaaaagtag
     5941 cttttactat cgggtcttcc gtatggttgt tttcaataac cggcgtagtg ctaactttgg
     6001 tcatggtgct ttttcatagt cggatagcag aactgatgca tactcctgtc gaagcgatgg
     6061 tagatacgaa aaactatatt ttggtatgct ctctgggtat tctgtttata gtaggatata
     6121 atgttgtatg tggtattttg cgtggattgg gtgattctaa aacaccactt tattttgttg
     6181 ggctggcatg tgtgataaat atagtgctcg attttatatt ggtcggttat ttccattggg
     6241 gggctacggg agcggctatc gctactgtaa ctgcacaagg agtcagcttt ggaatagcgc
     6301 tctggttctt ataccggcac ggattccatt ttgacttttc acggaaagat attcgattga
     6361 accggaatct gtctaaaaag atcttggtgt tgggagcacc tattgctttg caggatgctt
     6421 taatcaatgt ttcttttctg attatcactg tcattgtcaa tcagatggga gtcattgcat
     6481 ctgcttccct gggtgttgtt gagaaaatca tcgtgtttgc tatgctgcct ccgatggcta
     6541 tatcatcggc tgtggcaacc atgactgcac agaactatgg agcgggactt atcaagagaa
     6601 tgaataaatg tctggcttcg gggattggga ttgctcttgt tttcggtgtg tcggtttgcg
     6661 tgtattcgca attcctgccg gagactctta ctgctttctt tacgaaagat gctgctgtgg
     6721 tggcaatggc ggcagattat ttgcgagggt atagcatcga ctgcatcgtg gttagtttcg
     6781 tgttctgcat taattcttat ttcagcggac aaggaaactc gttattcccg atgattcaca
     6841 gtctgatagc cactttcctg ttccgtatac cgttgtcata ctggttcagc cagatagata
     6901 gctcgtcgct gtttatcatg ggatttgctc cacccatttc aacggtcgtt tcattattga
     6961 tctgtatctg gtatttacga tatacccaaa ggaaattata tttgagaggc acaatgatgc
     7021 ctgctatgtc gaattaggtg tttttaagtg acatatatta actaaaatct attttgtatg
     7081 gaagcttatt tgaagaaact ctgttttgag tatcaggtgg atgaaagaga agtgaaagag
     7141 ctgttggctc gaatggaaat ggtgtatctg gataaaggag aaacgattgc ttctgccaca
     7201 ttgccagaac agagcttgta cattattgtt tccggtattt tgcatacata taccactcat
     7261 gaaggagaag agagaaccaa tcggtttttc tctgcgggtg atgctgtgtt atgctataat
     7321 tcaagtcagt attctatcaa gacactgacg aaatgtgctg cttattacat cagtgaagag
     7381 gagattgaag agttgtgtgc atcttcaatt tcatttgcga atctggtccg tcaactgatg
     7441 gagtatcagt tttactttaa agaggaagag gatatgaatg cccgcaagct gacagtaagg
     7501 gaaaggtacc tctctttatt ggcggaaatt ccggatattc tgtacagggt gccattgaag
     7561 cacattaatc attacttggg ggcagatgtg accagtttgg gatatctggc cggaagttct
     7621 aaataggaaa tataacctag acatattttt ctatgtattc cttatcagat ggttcatggc
     7681 ttattcaatc gaatcgaatt tgaaaagtct ttggattatt tggtaaggaa tactattttt
     7741 gtattctgaa tgaaaaactc aatacctcga tatacttttt ataagcataa gtatgggagt
     7801 gaacttttgg tcgatgtagt agaactgaag tatgtgaaga agttcctggc taaaagtgct
     7861 gtccacactc taaattatta tgatattact tttataacag aaggtaaggg agctttttca
     7921 gtcgataacc aaacctatga agcaattcct cgtgacgttc ttttctctaa accgggggaa
     7981 atccggaact gggatactca tcatatcacc aatgggtatg ctctgatttt cgaagaagaa
     8041 tttttgtctt tcctctttaa agattctttg tttgtacagc atctttcgtt ttttcagata
     8101 gaaagttctt catcgctact acatttgtct gatgagcttt atacacgcat acttgaaacc
     8161 ttgcatgata taaagatgga gattgattcg tatcaacagg gcgatgtaca cgttttgaga
     8221 gcattgcttt atgaagtcct gatgttgctg gaccgtgctt accttaaaat gacttcgata
     8281 gaggagggca gaagtaggga agtttccaat aatcatgtaa gtaaattcat gaatttggtt
     8341 gctacacatg caaaagagca acattcggtt caatattatg cggataagct ctgcattact
     8401 cctaattatc tgaatgagat gataacctcg accatgggaa tcagcgcaaa acaatatatt
     8461 cagagcaagg tgatggaaga ggctaagagg ctgcttgttt atacggactt tcctatagct
     8521 gatattgcat ttgaactctg tttttcaacg gtttcttatt ttatccgtag cttccggcag
     8581 catacgggag aaactccgtt attgtatcgt aaagtacaca aaccgtaaaa agtgctattt
     8641 ctacctttct ttttattgca ttgctttcct ggcatttctc tactttcgca tcagataata
     8701 aaccaataat aaaaagtaaa atgatgagag acgcggaaaa aacagtaggc aacatgattg
     8761 ataagctgaa aacagctttt atcggttcga tagacggtga aggatttcct accatcaaag
     8821 caatgctgca acccagaaaa agaaagggga taaaaactat ttatctgaca acaaatactt
     8881 cgtccatgcg tgtggcgcaa taccgtgaga acaaccatgc gtgtatctac ttctgtgata
     8941 cgagattctt tagaggtgtc atgctacgcg gtacgatgga tgtcttgacg gatagtgcca
     9001 gtaaagagat gatctggcag gagggagata ccatgtatta tccggaggga gtgacggatc
     9061 ccgattactg tgtattgaag tttactgcta tttcaggacg tttctatagt aattttaaat
     9121 cggaagattt tgtggtcgaa taaggtgcaa gatggggtga ttggaatggt aataacggag
     9181 tgtgtcaaaa cgcagattaa cgcaaattat cgcagaaata attttataag tcgttgatta
     9241 atatatcaat ataattggaa taatctgcga taatttgcgt taatctgcgt tttattattc
     9301 attatgacac acctccttat atagtatcta tactattcct cataacacaa tnnnnnnnnn
     9361 natatagtat ctatactatt cctcataaca caataagttc tgcaattggt tgatgatgtt
     9421 ttgtttccat tcttgcagga agtcagcaaa agcggcttca tcttccaaga ataaagatac
     9481 tatcaggttc ttggcaagaa atggatagct caataggctg tagacagtca gaaatacaat
     9541 atgtatcgga acctttttaa gtttaccgtc ttccattgct gtcagtatac tgtctttcac
     9601 ttgggataaa gcatctccga actgaagttc ttttgcagtg gcaagcaagt ggtttacatc
     9661 acgctgtatt tctccgcaaa tgaatctggg aagacaggga ttacttgtga aaagctcaat
     9721 atactcatcc agaatcatgc ttagtcgctc cataaatggg atatcctgtt ttactatatc
     9781 ctgtattttc ggcattaaag acatgactat cgagccgaac acggctttga acatcttatc
     9841 tttggttctg aaataataat gtaaagtggg ccggttgatt cctaccgttg cagcaatatc
     9901 actcatgctg gtctccacaa atcctttttc tataaaaagt tgttgggcag tttttattat
     9961 ttgctgctct aaatcgctat gttccgttgt agccataatt ttagttgttt atgttgtcaa
    10021 taaaaagtaa taatctgttt gttatgttca catcgctgac gctactgtca aagtctaaag
    10081 atagtatatt catttgaggg cacagcgatt ttatacgttt ttctattcct ttttctacaa
    10141 tgtgattggc aatgcatccg aaaggttgca agctaatgac atgattgact ccttgggaag
    10201 caaaggatag tatttcaccg gatatcagcc aaccctctcc aaactgggtg cccggggaga
    10261 tgacttgttt agctttttct gccttttcaa agattgattc gaacggcgtg aagtaattga
    10321 aatttttgcc gatttcattc actttattaa tctgcttctg gactttcttg tataaccagt
    10381 cgataacaaa gtcgggagtg agttttcgct gcaagtgttg gttctgtctc actttcaggt
    10441 tgacaaatcc ctgcatgaag aaatcactta tcagtggcgg aatcacttcg atcttctggt
    10501 tgatgagcca tgaggtgacg tccttttgag caaaagggtt gaacttcagg aatatttctc
    10561 caacaatacc tactttgtga caggatctct gttcacagat tttgttgaag tctctggcag
    10621 cgagatataa gtaactcaac aagtcctccg gtttattttt ctggatgatg ggctgtgctg
    10681 tatccagata aagatcgcgc agacgggcgg cctgtccccg ttctttctca cgaacgacgg
    10741 ctgcataata gaatttagcg atacaatcac tgtataacac agacgcaagt atgattggca
    10801 aaaccttgag ccagtttact ttaaaaccgg attgctcatt ttcaatacca ctgccgaaag
    10861 caagtgatac caccggtgta ttggtgtatc cattctcaat caatgccttt tttatcagtg
    10921 aaatatagtt gctggcacga cattgtccac cggtttgtgt gatggcaacg cacgtattgg
    10981 caggatcata acgtccgctt ttaaaggctt ttactatgtc gccgacaatc aatgttgccg
    11041 gataacatac ctcattattg gagtatttca atccccagtc gcaagatgcg gtgtcgctca
    11101 acggtaacgt ttccatttca tatccggcca ctttcatgat ggatggaatg agtggtgaaa
    11161 tgaaaggcgt aaagaatgga gcgaggattt tcttcttttt gtctttcttg gtgaaaggag
    11221 cagttgaaac aaatggctcg ggatctttcg cttgagaatg tttcaaactg aaattcaagc
    11281 tttccaccaa cgagcggact cgtaatttga tggagccgat attattaaca tcgtctatct
    11341 tgagcaaagt aagattcttg ccgtatcgtt tcagcaagtt acgtacttca tctataagga
    11401 aagcatccgg accgcagcca aaagaagtca tctgcatata ttgtatgtca ccctcttgca
    11461 ttgccgccca cttggttgct ttcagaatac ggttggtaaa tgcccattga gagaggtaat
    11521 gagtcttttc caatgaaatc tcctgctggc ggacaatatc atcagttatc acataaactc
    11581 ccatcgcagc aatcatgtcc gaaaccttgt gctgtatcag tggatcgcta tggtaagggc
    11641 gtccggcgag taagataatc agtttgtgtt tttcccgtcc ctcgttcaga acttcctgat
    11701 tataggcagc aattttttct tcgaaagcat attgttcctg taatgcgcgt gagaaggcat
    11761 ttttgcatac ctcatccctg atacccaaag atttcagata ttcatagcat tgtttataca
    11821 gcaatgcttc atctttgaag gtgatagtcg gagcatctat cggtatattc tcttcctgta
    11881 cacttttgat gacttccgaa taaccggaaa cgatggggca attatagctg ttttgctgtt
    11941 gcttatcctt tttctcgaaa acaacgaacg gcataaatat ccggttgacg ttttgcagtg
    12001 tcaggttacg gatatgactg tgcacaagtt tggcagggaa gcagatgtta tcagacatca
    12061 ccatgccggc agcagtctcg tatttgctga atgtagaggg ggccgacaac tgtacctgaa
    12121 tgccgcaagc agtaaataag gtatgccaga aagggtattc ctcatacata ttcagaatac
    12181 gtggaatgcc tatggtaaat aggggttgtg gaatgtctgc gctccggtcg aataataatt
    12241 ccagcttttt atcatacgta ttgatgcctt tgtccgcatg gcttccttta ttggaaaata
    12301 ccttttcaca tcggttgccg gagaagtaat ggttgtcatt gttgaacgta tatcgcataa
    12361 tggcgcactg gttctcgcac ccccggcatt gaagttgctt ggaagtatat tgcgcccatt
    12421 ggagcatctc gttcagctcc gtcacccggg cattttcgat ttgtttggca tatagggcac
    12481 aaccaagagc acccatcaat tcaggacagt tactgcggaa ggtttgtttc ccggtcagct
    12541 tttccagact tcgtacgatg gaatcattac gcatggttcc tccctgcacg acaatatggt
    12601 cgccaagtat ctccgtgtct tttaattgca gaaccttata caggcagttt ttaacaacgg
    12661 aataagataa tccggcagct atatccgcta cggacgctcc ttcccgaagt acctgtttta
    12721 ctttggagtt catgaagact gtgcaacgtg tacccagatc acatggtgct tgcgaaaaac
    12781 aagctgcttt ggcaaagtcc tccacactgt aatccagcga ttgcgcaaat gtgctgataa
    12841 aagaaccgca accggaggaa caggcttcat tgatttcgat tctgttgatt actccgtcgt
    12901 tcacaaagat ggctttcata tcctgccctc caatatccag gataaaagaa acttctttgc
    12961 tgatatgttt ggcagcagca taatgagcga tggtttcaat gattcccgca tccatgtgga
    13021 aagccgcttt tatcagatct tctccgtaac cggtagaaca tcctcctttt atgcgcaggg
    13081 tagttcctcg tctccggcat tcttcatata gtttctgcaa gccgttctct actgttttta
    13141 tagggtttcc gttgttgtcg tgataatagg agtaaaggat acgatgattg ttgtcgagta
    13201 ctacgatttt ggtggtagta gagccggagt ctatgccgat agttgcttcc tgtaatccgg
    13261 gacgcagact ggcatattga attttatact ggtctttttc ttttttccat gaccgatatt
    13321 cttcctcact gtcgaatata ggagaaagat cactctggaa aggtgaggta acacttagtt
    13381 tgttttctat tacctgtatc aggttggaga gatgaatact ttcttcattg ttctctgcca
    13441 atgctgctcc ccaggcaggg atcagatttc ctttttccgg taatatgaaa tctgtatctt
    13501 gtgacagatt cagatagttg gcaaatgctt ttcgaagggc cggaataaaa gtcaatgggc
    13561 caccgcagag taataccgga gctacgatat tgcaaccgcg tgcaagtgtg acagtggtct
    13621 gtacggctac tgcatggaaa atggaagctg ctatattttc tttagatata tttttggcta
    13681 tcagattctg tatgtccgtt ttgcagaata ctccgcagcg tgaagcgata gagtatacct
    13741 gattggaacg aagtgctagt tcattcaatt cgtcgatgga gactccaagc agaatagcca
    13801 tctggtcaat gaaagccccg gttccgccgg cgcaatttcc attcatgcgc aggtctgtag
    13861 cctgtccgtc ctgaaagaaa acaactttcg catcttctcc tccaatatcg atcatagtgg
    13921 ctgtgtgcgg atgctcccgg cacacatagt ttgttgcagc tacaacctct tgcacaaacg
    13981 gcagagagca tttctctgaa attcccattc caacagagcc cgtaatgtgg aaagataaag
    14041 gaatatcacc caactgttcc tttatttgat aaagaaatcc gagtaaacat tcttgtattt
    14101 ttgcctgatg ccttttgtat ccggaaaaca agactgtagt tccatcttta tccaatacta
    14161 ccatcttagt ggtagtagag cctatatcta aacccacttt atatacattc atataccaaa
    14221 tatcttaaat tagacctcgt gtttgacatc tgtgtcagac gcaaatgtat gtaaaaatat
    14281 ggtagatacg gcaaatcgta attgaagttt ttgatttaat taacgaattg ggaaaaaaga
    14341 aagatggaat gtgagggagg aaaacgatcg tgtaaaaaaa gacgtaaatg aataattgtg
    14401 tatttatatt acttgttggg ttgtagtaga tcttttatgg tgaatcttag aaatcttgtt
    14461 tactctattt ttgacaaaag gtaacgtggc ttttaataaa cccggattct gtttataata
    14521 aactttttga tagttttagt aaaacggtat tcgagtttat tataaactat tgtagaacag
    14581 ttctaggatc agacgagaga ttttaagctg aattataaac aaaatgaggt tgtgtcaaaa
    14641 cgttggcaca acctctttta tattttacag ttctgctata
//
