LOCUS       c00003_gnlPro..        16287 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CPOLBPFM_3.
ACCESSION   c00003_gnlPro..
VERSION     c00003_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 20:10:56
            Original ID  :: gnl|Prokka|CPOLBPFM_3
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16287
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16287
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2735:6287](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2736..6287
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16287
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16287
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(3..68)
                     /locus_tag="ctg3_1"
                     /transl_table=11
                     /translation="MKQVITCHVCTVLDLVDNFACY"
     CDS             complement(163..1377)
                     /locus_tag="ctg3_2"
                     /transl_table=11
                     /translation="LNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMASELALL
                     PMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIR
                     KRLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKS
                     FVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFA
                     MEFRSSSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLE
                     QELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPT
                     STGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFIS
                     KSVFL"
     CDS             1525..2703
                     /locus_tag="ctg3_3"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2736..6287
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_4"
                     /sec_met_domain="PFOR_II (E-value: 8e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 9.3e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 9.3e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 3.2e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 5.1e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00026, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.6e-24, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6440..7306)
                     /locus_tag="ctg3_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7327..8151)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.6e-28, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8148..9374)
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9674..10012)
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10096..11391
                     /locus_tag="ctg3_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11531..14371)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.3e-19, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 gtataacaag cgaagttgtc aactaaatcc agtacagtac acacatggca tgtgattact
       61 tgtttcatgc aatgaaactt tttgtttctc ggtgtggaac caatggtttc actacatgaa
      121 actatcagtt tcacaccgag aaaccataac ttcgatataa tatcacaaaa acacgctttt
      181 tgagataaac acccacgccc gataactact ctttttatga gccggcacca atgacaaata
      241 gcctgatttt attcttcctt gttctatttc caaaggataa gcctcctcca tttctttgtg
      301 tgctctccag gctgttcctt ccgtagggta atagcttatt tgaaaagctc ctgttgaagt
      361 aggatagata taatggtcat aaatatgacg cgctactact cccatattca tcctcaagtt
      421 gatttccacg caaggatgaa tccgataaac aggagattct ggaaagcgac agatcatcat
      481 atccactccc aaataaccat tataaatggt tccgaaacgg agggataatt cttgttcaag
      541 gcggtcgcgc aatttataaa tttcttcgac agggatatat tccaaaagat tccgttcgat
      601 ggctgcatct gaaatcagca gattaccttc gtacgcccca cttccacccg tacggaattg
      661 agagtatccg gcaaagccaa atcgaccatt actcgaagaa cgaaattcca tagcaaaatc
      721 ttccacctta ttatatagag gttcgccaat aacacctcct tgctgtttgc caatgcgtga
      781 gcaccaaccg gaaatagaag gagtatatac acctttgcac cagttcagcc ctttcccgct
      841 accggataaa ggagctttca gtaaacaagt atcatgtgat tctacaaatg acttccattc
      901 ttcgggaaac gtcaggtaaa aagactctcc acaaaaacag gctcccagtt gtagctgtgg
      961 taataatccc acagcgcagg aacgatggga acagaaacgc agtttatcca attgctcaat
     1021 agaaggaagc tcgctttctt ccactcccaa atccaacagt cgttttctta ttgctatatc
     1081 ccagccccaa ggacgaatat ccaaattccg ctccgaagca agttcaggtt ctgtcatcaa
     1141 atcaaccgaa agtcctaata attcctgtat cttcttcaca tagtcgagat tataagcgga
     1201 aggagccaat acaacacttc cctcttctgc ataccacatc ggcaacaaag ccaattcgga
     1261 tgccatctgc cgggcggaag ccggtgccat atagtttgtt tcaccgctgg ctaacgccaa
     1321 atcatgttcc ggattgaata tataaagagc cttttttgtc attttaaacg aattcaaaac
     1381 tttattctgc aaatatatac aggaaatagt caggaatggc tacaataaac agaaagttct
     1441 aattaaactc acaattttgc catctctact ttgcaaatcc taaaaaaagc agtatatttg
     1501 ccacccgaaa aacaaagaac tgaaatggaa tcattctatc gcacacacgc ctacctcgtt
     1561 gagcacacca atgcccccgt tcgccgcgat cttatggacg agatcgactg gagcgaccgc
     1621 ctgattggta tcaaagggac acgtggcgta ggaaaaacca ctttccttct ccaatacgcc
     1681 aaagaaaaat ttgggaacga ccgctcctgc ctgttcatca acatgaacaa cttctacttc
     1741 tctggccaca gcattgtaga ctttgctaac gaatttcaga aacgtggcgg aaaagtattg
     1801 ttgatcgacc aggtgttcaa acatccggaa tggagcaaag agttacgcat gtgttacgac
     1861 cgttttccta acctgaaaat tgtcttcacc ggctcgtccg tgatgcgact gaaagaagaa
     1921 aatcttgaat tacgtgatat cgccaagagc tataacctgc gcggattttc ttttcgcgaa
     1981 tacctgaact tacagacagg catgaaattc agggcataca gcctcgaaga aattcttagc
     2041 actcacgaac agattgccaa aggagtactc tctaaagttc gtccgctgga ttacttccag
     2101 gattacctgc atcatgggtt ctatccgttc ttcctcgaga agcgtaactt ctcggagaat
     2161 ttgctgaaaa cgatgaacat gatggtggaa gtagatatac ttctcatcaa acaaattgaa
     2221 ctgaaatatc tttcaaagat aaaaaaatta ctatatttgc tcgctgtcga cgggccgaaa
     2281 gctccaaatg tgagccaact ggcaagcgac atacagacat ctcgcgccac ggtgatgaac
     2341 tatatcaagt atctggcaga tgcgcgactc attaatctgg tttatccgaa aggggaagaa
     2401 ttccctaaaa aaccttcgaa gataatgatg cacaactcca acctgatgta ttccatctac
     2461 ccggtgaaag tggaggagca ggatgtgctc gacactttct ttgtgaattc tttatggaaa
     2521 gaccataagg tacataaagg agataaaaac gtctctttta tggtggacga agtaatgccg
     2581 ttcaaaattt gccaggaagg agcaaagatc aagaacaatc cgaatgtgac gtacgcgttg
     2641 cataaggctg aaataggtcg gggcaaccag atacctctct ggatgttcgg ctttttatat
     2701 taaaagattt atttacttaa atatttaatt tagttatgac taaacagaag aaattcatca
     2761 cttgtgatgg taaccaggct gcagcgcata tctcgtatat gttctctgaa gtagctgcta
     2821 tctaccccat cactccttct tcgactatgg ctgagtacgt agacgaatgg gctgccgcag
     2881 gacgtaagaa catcttcggc gaaacagtat tggtacagga aatgcaatct gaaggtggtg
     2941 ctgccggtgc agttcacggt tctcttcagg ctggtgcgtt gactactact tacactgctt
     3001 ctcagggtct tctcctgatg atccctaaca tgtacaaaat tgccggtgag ttcttgcctt
     3061 gcgtattcca tgtatctgct cgtacattgg cttctcacgc attgtgtatc ttcggtgacc
     3121 accaagacgt aatgtcagct cgtcagactg gctttgcgat gttggctgaa ggctctgtac
     3181 aggaagttat ggatttggct ggtgttgctc acttggctac tatcaaatct cgtgttccgt
     3241 tcatgaactt cttcgatggt ttccgtacat ctcacgaaat ccagaagatt gaaatgttgg
     3301 aaaatgatga tcttgctccg ctgattgatc aggaagcttt ggctgaattc cgtgcccgcg
     3361 cactgaatcc gatgaatccg gttgctcgtg gtatggctga aaatcctgac catttcttcc
     3421 aacatcgtga atcatgcaac aactactatg aagcagttcc tgctatcgta gaagaataca
     3481 tgaatgaaat ttctaagatt acaggtcgta aatacggttt gttcgattat tatggtgcag
     3541 aagatgcaga acgcgtaatt atcgctatgg gttctgtaac agaagctgcc cgcgaagcta
     3601 tcgaccactt ggtagcaaat ggcgaaaaag tgggtatggt tgccgtacac ctgtatcgtc
     3661 cgttctctgc taaacacttc ctggctgctg tacctaagac tgccaagact atcgcagttc
     3721 ttgaccgtac taaagaaccg ggcgctaacg gcgaacctct ttaccttgac gttaaagact
     3781 gcttctacgg cgcagaaaat gctccggtta tcgttggcgg tcgctacggt ttgggttcaa
     3841 aagatactac tcctgctcaa attctttcag tattcgagaa cttggccatg ccaatgccga
     3901 agaatcactt cactatcggt atcgtagacg acgttacttt cacttctctt cctcaaaaag
     3961 aagaaatcgc tttaggcggt gaaggaatgt tcgaagctaa attctacggt ttgggtgctg
     4021 acggtacagt aggtgctaac aagaactctg taaagattat cggtgacaac actgacaaac
     4081 actgccaggc ttacttctct tatgactcta agaagtcagg tggtttcact tgttctcact
     4141 tgcgtttcgg tgatactccg atccgttcca cttatttggt aaatactccg aacttcgttg
     4201 cttgtcacgt tcaggcttac ctgcacatgt acgatgtaac tcgtggtttg cgtaagaacg
     4261 gttctttctt gctgaacact atctgggaag gtgaagaact ggctaagaac ctgcctaaca
     4321 aggttaagaa atattttgca cagaacaaca tttccgtata ctatatcaac gcaacacaga
     4381 ttgcattgga aattggtttg ggtaatcgta ccaacactat ccttcaatct gcattcttcc
     4441 gtatcacagg tgttattcct gtagaccagg ctgttgaaca gatgaagaaa ttcatcgtta
     4501 agtcttacgg taagaagggt gaagacgttg ttaacaagaa ctatgctgcc gttgaccgtg
     4561 gtggtgaata caagacttta gctgttgatc ctgcttgggc taacctgccg gatgatgcaa
     4621 aagctgaaaa caacgatcct gcattcatca acgaagtagt tcgtccgatc aatgcacaag
     4681 atggtgactt gctgcctgta tctgcattca agggtatcga agacggtact tggtatcaag
     4741 gtacttctaa atacgaaaaa cgtggtgtag ccgcattcgt tcctgaatgg aatccagaaa
     4801 actgtatcca gtgtaacaag tgtgcatacg tttgtcctca cgcttctatc cgtccgttcg
     4861 tactcgatgc tgaagagcag aagggtgcta agttcgaaca attgaaagca gtaggtaaag
     4921 tattcgacgg tatgacattc cgtatccagg ttgacgttct cgactgtctg ggttgcggta
     4981 actgtgctga catctgtccg ggtaatccga agaagggtgg caaagcattg acaatgaaac
     5041 acctcgaaag ccaattggct gaagctgaca actggactta ctgtgctgaa aacgtgaaga
     5101 ctaaacaaca tcttgttgat atcaagtcta acgtgaagaa ctcacagttc gctactccgt
     5161 tgtttgagtt ctctggtgct tgctctggtt gtggtgaaac tccgtatgtg aaattgattt
     5221 ctcaattgtt cggtgaccgt gaaatggttg ctaacgctac cggatgttct tctatctact
     5281 ctggttcagt tccttctact ccgtatacta cgaacgaaaa cggtcacggt cctgcttggg
     5341 ctaactcact gttcgaagac ttctgtgaat tcggtttggg tatggaattg gctaacgaaa
     5401 agatgcgtgc tcgtatcgtg aagttattca acgaaatcct tgctgccgac aacgcttcac
     5461 ctgaagcaaa agaagtgctg aaagcatgga ttgaaaacat gtacgatgct gacaagacta
     5521 aagaattggc tccccaagtg aaagcagtga ttgaagaagg tctttctcac ggatgtccta
     5581 tttgcaaaga actgaaagga ctgactcaat atcttgtaaa acgcagccaa tggatcattg
     5641 gtggtgacgg tgcttcttac gatatcggtt atggtggtct tgaccatgta atcgcttccg
     5701 gtaaggacgt taacatcctc gttctggata ctgaagttta ctctaacaca ggtggtcagt
     5761 cttctaaggc tactccggta ggtgctatcg ctaagttcgc tgctgctggt aagcgcgtac
     5821 gtaagaaaga cctcggtctg atggctacta cttacggtta tgtatatgtt gcacagatcg
     5881 ctatgggtgc tgaccaagct caaactctga aagctatccg tgaagctgaa gcatatccgg
     5941 gaccatcttt gattatcgct tacgctccat gtatcaacca cggtctgaaa gcaggtatgg
     6001 gtaagagcca ggaagaagaa gaaaaagctg ttaagtgcgg ttactggcac ttgtggcgtt
     6061 acaacccagc tttggaagaa gaaggcaaga acccattcca attggatagc aaagaaccga
     6121 actgggaaga tttccaaggt ttcttgaagg gtgaagttcg ttacgcttct gtaatgaaac
     6181 aatatcctac tgaagctgaa gaactgttta aagctgctga agaaaacgct aaatggcgtt
     6241 acaacagcta caaacgtttg gctagagaaa actggggtgc tgaataatag taatacccta
     6301 taaatataaa gcggtaatct tatcaaagat taccgctttt ttattgtatg aactctgtcc
     6361 aacataaaca gtactccctt tttcccacta gagttcatgt ctattttata tttaaaatta
     6421 agaataacaa tgctccaatc tatttattct ctgacttcgg aatccaacta tccaccaaca
     6481 gccgatgctc atccctccat ttacgggcta tttcttcttc atccatcctg gcatccttca
     6541 tagctgtcat aaaagagcta agttcttctg tcgttagttt gatgttgcca aagaattcgg
     6601 cagcaaacgg atctttctca ctgaatcctt tccatgcaat agcatgtatt tcttccaagt
     6661 ctccatatac tttcttcgga tcatccaaga atttcaagtc aaactggtcg aacatccaat
     6721 gcggtgtcca ccccgtaatg acaatccatt ctcctttgtc catcgctttt ttcaaagaag
     6781 ccagcatggt ggaactactt gaagtcatga gggtataccc atcaagtccg taagcagcaa
     6841 tggccttatc ggtcgtcttc attatccctg ctcccgcatc aattcctact atttcagagg
     6901 aaaaacggtc tttattagct tccagctcat taatagagtg gatcgtaaca tattgaggaa
     6961 caaccagtcc gacgcgagct tctccgtata cctccccaaa aaattcgatg ctgtctccat
     7021 actgatccat ataatctttc atcgttattg gtaaccatgc atccagaaac acatctgatt
     7081 tctttcctga catagataca aaaatagggg caagatcagc attttgcaat tcaacctcat
     7141 atccatgctc ttccaatacc accttagcca aatgactcat ggcaatacct tccagccaat
     7201 tggcataggc tatttttact ttctttttct ctaagtctga attagtacag gaagctagca
     7261 aaagcatagc tgacaatact attcctacta ttttatatat tctcatacgt attttatcct
     7321 ttccgtttag ttcttatttt ttcgtcctgc cattccttgc gtgatacggt ctaagatgat
     7381 agctaaaata acaactgcta taccaccttc aaacccaagt ccgattttca tttgggtaat
     7441 acctttcaat acaatttctc ccagaccacc ggcagcaatc atggcagcaa ttacaaccat
     7501 agaaagcgac atcattattg tctggttgac accagtcaga atggtgggca acgccaaagg
     7561 aagctgcact ttatacaata actgccaacg ggtagctccg aacgaacggg aagcttccac
     7621 tacattttta ggaacttgcc ggattcccaa tccggtaagg cggaccacag gaggcatagc
     7681 aaagataatg gtggcaaaca ctcctggcac tgctcccaat ccgaaaaaca aaacagcagg
     7741 aatcagataa acaaaagcag gcatcgtctg catcaagtcg agaacaggac ggagtatttt
     7801 ctctgcacgc gaactgtttg ccgtccatac tcctaaaggt acaccaacaa tcagggccag
     7861 acaggtagat gaaaaaacga gagctagagt ttgcatggta gcctcccaga atcccattcc
     7921 atagatcagt aataatccca atgcggtgaa aattgccgta ccgcgtcctg ctttcatcca
     7981 tgcgagtgca gcaagtacca aaatggttat ataaaaaggt attccgaaaa gtatgtgttg
     8041 gaatcctata ataaaactac cgatgcccgc attcacggca tcaaagaaag tggaaaaatg
     8101 tatcatcatc caattgatgg ccatctctat atattgtcct atatttatca taaatctatt
     8161 gcgttttgaa ttatttcgtt tatttcttct ttatctttcc cggtcacttc gatgattaag
     8221 gatgaaagcg ggattgttcc taaaaactcg cgcgtctcat caatcaccca taccggcgaa
     8281 ttgctctttg tcattagagg aagtatatcc tccaacaccg tatcctccaa cacagaatgt
     8341 acttctgtac gcacaatcgt ttcaatggat ttttcctgtt tgctacgtaa cttaagcaag
     8401 tcgttcagac gtacttctcc gaccagttta tcatcggcgt ctatgacagg taatacggtg
     8461 atattcttcg cacgcatctt acgaatcaat acttcgggac cttctttctt cagacgggcc
     8521 accaacggtt tgtcaatcat taaagaagag gcggtaataa ttttgctcct atccacgttt
     8581 tcaacaaaac gggctacata atcgttagcc ggttcagtca ggatttcctc cgaagtacct
     8641 acctgcacca cttctccgtc tttcatgatg gcaatacggt cacctagctt aattgcttca
     8701 ctcaagtcgt gggtaataaa aacaatcgtc tttttcatct ttgattgcaa ggccagtagt
     8761 tcatcctgca tctgtacgcg aatcagagga tcgagagcag agaaagcctc atccattaaa
     8821 agcacttcag gattattagc cagagcgcga gccagtccga cacgctgttg cattccaccg
     8881 gaaagctcgc ctaccatctg attttcatat cctttcaatc cgacaagctt catgctttcc
     8941 atcgctttct tctcacgttc ctctttcttc actccctgaa gttcgaggcc gaacgcgata
     9001 ttgctcaata cggaacggtg aggtaacaga ccgaaattct ggaaaaccat cgccagctct
     9061 ttccgacgaa cctgcaataa ttctttttcg gaaattttag atatatctac tccgtttaca
     9121 agcacttgcc cggtagtagg acgtatcaga cgattgatac aacgcagtaa tgtcgatttt
     9181 ccacttcccg agagtcccat tatcacgaaa aactctcctt cattaattga aagattggca
     9241 tctttcactc ctaccgtaca accggtatct ttcagaattt cctctttact cttatctttt
     9301 ttcaacatct tgagggcttt ctgcttctcg ttaccaaaga taaggtacaa atcctttatt
     9361 tctattttac tcatataata tattggttta gattataata tttgttttgt tttcaactgc
     9421 cgcattcctt attctcactt acgataaaca agttgaatgt tcgcatggtt cagtcatgtc
     9481 acatgataac atgacggtcc gacgtttttt aaatggttaa aaaaaaacag acagagtagt
     9541 ttaaaaggaa tagaatttga taagattatc ctcttaatga acagtagaaa acagtatttt
     9601 cataaataaa taacagtctg ttcttgcata ttgttggcac aaaggtaagg aaaatagatt
     9661 aaatatgcaa atttcattca ggtacggagt aattccaaag atgctttttc aagtctacgc
     9721 atccattttg tttgaaagag atcccttctt ccaacaagag ttgtttctgc tctgtccaac
     9781 ccggaacaag ccgtcccgac gcattgacaa cccgatgaca aggcgcagat aaatcatccg
     9841 gaatctgttt caaagcacgc cccaccatac gggaacattg agacattccc aataatgcgg
     9901 caattccccc ataggtagaa actttaccta ccggaatttc tcggacaacc tgatacacct
     9961 cttgacaaaa ggatgcggaa aggctcgcct tatctacttt ataatctttc atcactcaaa
    10021 cattacttta tttcagttcc aaaactagat aaaaagaaaa gaatttgcaa ataataaaag
    10081 catttcaaat aaaatatgca actttatttg ctttatttac aaataatccc gacctttgta
    10141 cccattaaaa gcaaccctat tattaacaaa acaagcactg ctgttatgaa aaagaaaact
    10201 atcctgttcg cttcttgttt attgggagca ctggctttca gctcctgtga gaagaacctt
    10261 tatgatgaaa gtaaacaacc cgagaaagaa aagaagatga ctgacttgga agtacctgcc
    10321 gatttcgact ggaaaggttc tcaaaatgcc aaagtgaaaa ttgccagtca atcaactgct
    10381 actatttctg tatttctaga agaaaattgc aatgaagagg ctttgatgct tcgaatggat
    10441 gtcgatgcca acacatcaaa attggaactc ccaattgaaa ttcctgcata tataaaaaat
    10501 gtgtatgtaa aatatggtaa tggctctgaa atacaaactg ttcctgttga aagtaatggt
    10561 actatttcta tagtagtacc tgctaacgct acggcattat ccagagttac cacaagagct
    10621 aataaagaag ttgaaacgaa caacatcttc aattatccgg gatatggcaa cggaactatt
    10681 atgttcgaag atatgtatcc agctttaggc gattatgatt ttaatgattt tgttgcatgg
    10741 tataatttcc aaattgacgg tttttattgg agtcacaatc aatgttatgc agaatactta
    10801 atgataggat tccaaatcag agctatagga ggtatatatg actacaatcc ttatatccgc
    10861 ttggcagaag tacaatataa tgaacttgat ttagaagaaa ctcaaatgta tcttgagcgt
    10921 aacaatcctg aagaggctga aaatatcaaa atcctaaaag gcccaaaagg ggaattgatt
    10981 atttcactaa agaaaccggc cattcctaac ggatacaagt attataatac ggaggtaaat
    11041 gaaaaaacaa agcctaaaaa aatgatggcc atttacttgg tgttcaactc acctgttaac
    11101 gttaaaagcc tacaagacag taaaatggac ttttatattg caaaaactaa taaaggacaa
    11161 gaaatccact taaaaggtta tagcccggtt tattataaca gcaacgaaag ttatgtaaat
    11221 gaagacaact ttatatgggg attaaaagta cctgcatctt tacatcatgc cagagaagaa
    11281 gtaaacttct tggaagcata tccagacttt gaacaatggg taacatcggg aggtcaagag
    11341 aaccaaagat ggtggaataa gccaaaaacg aataagttga ttatgaatta ataaatatac
    11401 agtaaatcat atactgaatt aaataagagg taaggtatgt caatagattt ccttacctct
    11461 tatttttatc atatgaattc tagaagtata aacagataaa tgctcaccac caaattttgc
    11521 agattctatc ctatcctttc ctcttcaaca aatctgtcgg actctctcca aactgttctc
    11581 tataacattt agtaaaataa gaaggagaac taaaaccaac ttcataacct atctctgcca
    11641 ctgtcatatc cgacgaagca agcagggaag cagctttctt caaacgagct atacgaagca
    11701 gttcattcgg ggaataatta gttagggatt tgattttgcg atagagttgc acacggctta
    11761 atcccatatc tttacccaag tcttccacat tcaaatttga atctcccatc tttgcctcaa
    11821 tcaaagcttt gaatttttcc acaaagtctt tatccatatc acagacatcc tctttcgcca
    11881 acgtttgtcc gtcaccaaaa aactgtttca ggcggcggtg tgaatctatc agattacgaa
    11941 cgcgtgccaa tagtaattgc gaactgaaag gcttggagat ataagaatct gcaccaccat
    12001 catacccttg aattcgttgt tcatccaaag aacaagctgt caataggata acaggaatat
    12061 gacaggtttg taattcgctt ttcaagcgac gacaacattc aattccatcc attccgggca
    12121 tcattacatc ggagataatc aagtccggga catatttcat agctttacga ataccttccg
    12181 agccgtctgc agcttctata acagtataat cagtatgaag caatccatgc acatataagc
    12241 gaatatcagc gttatcatca ataatcagaa cgcaaggttt ggaagagtcg taactttttt
    12301 ccaattcctc ttcttcgtaa gttaaagcat cattcaagct cgaagaaccg gaataaccgg
    12361 aagttgcagg agttgccgga accccagcaa cggcagaggt tgtagcatcg gtggaggtta
    12421 cagaagtagc agacacagag aatgccggag agttttcaga aacaacagtc tcgcaagtct
    12481 gcacaggcaa atcaacggta aagatagttc cttgcttttc atcactttcc accgtgatgg
    12541 tacctttatg caattccaca aaagccttta ccaatgccag tccaataccc gaaccggcat
    12601 ggtgcatatc tatcttatag aaacggtcga aaatattccg gatatgctcc gcagaaatca
    12661 ttgaaccggt attggcaacg gtaaagcgaa tccagcaatg atcgtcttta gtcagggaag
    12721 acaagcgtac agttactttt ccgttttccg gagtaaattt gaaagcgttg gaaaggaggt
    12781 tgaaatagat gcgttccaac ttttctacat ctgccaatgt gcggtaatcc gtatccggca
    12841 tataatcgaa tgagaaatga atatgcttct tccgggctac tgccatgaaa gattcgttcc
    12901 atccttcaaa agaagaaaga atgtctaacg aaataggagt atattccatt tttccattct
    12961 cgtatttacg aaaatccaga atctgattga caagacgcaa aaggatattc acgtttcgct
    13021 gaactaacaa taacattcgg cgctgatctt cactcaaaga cgaatcagcc agtaaatgct
    13081 ctaccgggtc ggcaactaat gtcagtggag tacgaaaatc gtgagatata tttgtgaaga
    13141 aaaccagctt ggcatgagtc gcttcttcca gttgatgaga aagctggata agctgatccc
    13201 gttgctcttc gagtttatcg cgctgttgct ctacttgttt cttctgttcg gacaactctt
    13261 tattcaggcg attcttggaa cggagggatt tatagactac caacaacaat cccgctacta
    13321 ataaaagaat aaccaagccg ccatacatca cgacctgctg cgtagctaca cgcgacagat
    13381 acccaccgat acgtccgttc aatgtttcaa tcttctgatc cagttccgag atatgggtag
    13441 tctgaagttg cataacgtgc gcgttcgtgc ggtctacaac ggcagtattc atgaccgttt
    13501 cgcgaggata agacttcttc tcaagaatat tcatggccag ttgcatcact ttgtccccat
    13561 tagtcggata aataaaagtt gcatccagca cattgtcaag caccaattca agcccgtttc
    13621 ctttgccggg cagggcatca atgccaacaa aaatcattac cttttcacgt ccggctttct
    13681 tcgcagcttg ataggctccc ggagcgatac ggtcgttatg tgcatatacc gcatcaatct
    13741 tcggatgacg gcgaagcata ctatccattt ccacttctgc cggttcacgt tcccaggcag
    13801 catccgcttt atcaatcagt ttgatatccg gataattgct gatagcagcc ataaatccct
    13861 gatggcgttc catggcaggg gtggaaccac ccagtccggt aagctccact acattccctt
    13921 tccctttcag acttgatgcg atataatttc ctaccgcacg acctatttca taattatcgg
    13981 caccgatata ggcagtatat ttatcagaaa gtatcttccg gtctacaaga atgacaggta
    14041 ttcctttctg ataggcctcc tccacaattg gagtcatggg agccgcttca ttggcggaaa
    14101 ttatcagtaa atcaactcct ttatctataa aataatgaac atcttccgcc tgcttacggt
    14161 tatcatccgc cgccgagcgg atttcaaccg acactccatc ataaaacatc gcttcgcgaa
    14221 gaatctcatc attcatcttg tgcctccaag agtcatcgct acattgggcc accccaatac
    14281 ggaaacgagg cgcatcctgc cgacaggccg ccaagcccaa aagacaaaac aagactgtta
    14341 tccacttcgt atatttcatc gcttcaatca ttccctttct ttcgtatatc ttttgtattt
    14401 ctttctgtaa tccaaatttc tccccccgca ttatttgcat tcaccaccgg gaaatacatc
    14461 agttccactt tcacagggtt cagcgtatat tttccagtaa agcgtggaag caaaggaacc
    14521 gtaaactgat aagtacctac cggtaatttt tcgctaaaga taacagtttt ctctttaaaa
    14581 tactcacgat atacttcaga acgggagaaa ttaacaggtt ttgaggcata actacaacct
    14641 gccggaacag gaacttcgag catcacatat tgcgcaccct cctgtttcac ctgcaaggta
    14701 actgtcaatg taacaggtac acccgccacc aaagagtctt tttccaaagt cacctccacc
    14761 ttgaaagcat cactctgacg agcattcatc acacgcttca ttgaatagac actatacaat
    14821 aaaggctctt ttcccgtttt tgaaataagc agactgtcgc ttgctgtcag ccgggcatga
    14881 taaggaaatt ccgtaattcg ttgatgatcc ttaccgctca cagacaccga cgttcctgac
    14941 atccctccgg aacctgccag caaatcggtc agaacagttg ccacagccga agaagcctga
    15001 tacgtattcc atccgcgctc cttagtccgc aaaatataca attgcatatt ttctttcaac
    15061 ttacacaggg aagggtcatt tttaataatc cggtaggcta tcaatgtatt tatcatctga
    15121 tttccctccc aataataagt acgccgtccg tcgtcacagt aaacaccttc cagcatatcc
    15181 tttttcagat aaggacgtac gctatcaccc acattcaccg aatccacctg ttgcttgatt
    15241 tcccagagaa gcagcttctc tttcaagtat gaaagaggac gataatactt gtttctattt
    15301 gccaacgagt cttctttctg ttccaattgc cggacgaaag gttccaataa tctgactgcc
    15361 gaagaataat ccgcctctac tttccactca tgcagagcat gaagtatttc tatatcttcc
    15421 agtttcattc ctcgataagg acgcgtatga gcatactcca ctttcaaacc attcagattc
    15481 aactccacag gataacctgc atcttgcgcc atcttcaaag cccgcagaat atgcgcagac
    15541 atccagaaag aagtattttc agagttcccc caccacgacc ataactgatg tttgttctga
    15601 tgattcgtca gtcgatggat gataggtcga attgctttat ctactttcac cttttcaccc
    15661 ttactctgca tatactgttg gtaagccaac aaaccgatta acttggatgc cagctgctca
    15721 ttgcacaaat atttgtatcc tgtcaagtaa ttcactgatt ctttatagat gtccaactga
    15781 ttgtcagtga tactcaccat cacttcttca tcctcgccgg attgcacttt aaccgtcttt
    15841 gcatcggaca gaatacccaa tgtgccctcc gccaattcag ttccctgtgc cagtatcgga
    15901 atcgtatatt cctctccatc ctgatagcca tcgtcgcgag tgaaaagata gctgatggtc
    15961 acgctatcgg catgaactgc ctgcatcggc actgtttcat gaaatccctc catgaaactc
    16021 acttcctgcc gtttcaacgt atccgttccg acgcagaact gtgtctttcc ggctatgtgc
    16081 tgcccatcca gataattgcg gatagtcccg accaccgtac tctgatcccc ctccaccaag
    16141 aagcggggag ttttcaactc cgccatcaac ggtttgtaag agcggacgaa acgtcggaaa
    16201 gtacccgtct gcaaacgacg gttcatgcca taaacgacag tttcccattt cgtcacatta
    16261 tcggggaaag ttgtttcaaa ctgtacc
//
