LOCUS       c00038_gnlPro..        16298 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CFELAOPH_38.
ACCESSION   c00038_gnlPro..
VERSION     c00038_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:02:40
            Original ID  :: gnl|Prokka|CFELAOPH_38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16298
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16298
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2746:6298](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2747..6298
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16298
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16298
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(174..1301)
                     /locus_tag="ctg38_1"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRSSGNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLSEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1536..2714
                     /locus_tag="ctg38_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNLNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2747..6298
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_3"
                     /sec_met_domain="PFOR_II (E-value: 1.3e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.5e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.5e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-12, bitscore:
                     38.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.2e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.5e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNQILEGDNAPAEAKEVLKAWIENMYDADKTKE
                     LAPQIEAIIEQGIAAGCPVSKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6451..7317)
                     /locus_tag="ctg38_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWMVITGWTPHWMFDLFYLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7338..8162)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg38_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.5e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8159..9385)
                     /locus_tag="ctg38_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9684..10022)
                     /locus_tag="ctg38_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10106..11401
                     /locus_tag="ctg38_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNLYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11543..14425)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62.8; E-value: 1.2e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.4e-20, bitscore:
                     62.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYMKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAAYGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 aactaactta ggtataacaa gcgaagttgt caactaaatc cagtacagta cacacatggc
       61 atgtgattac ttgtttcatg caataaaact ttttgtttct cggtgtggaa ccaatggttt
      121 cactacatga aactatcagt ttcacaccga gaaaccataa cttcgatata atatcacaaa
      181 aacacgcttt ttgagataaa cacccacgcc cgataactac tctttttatg agccggcacc
      241 aatgacaaat agcctgattt tattcttcct tgttctattt ccaaaggata agcctcctcc
      301 atttctttgt gtgctctcca ggctgttcct tccgtagggt aatagcttat ttgaaaagct
      361 cctgttgaag taggatagat ataatggtca taaatatgac gcgctactac tcccatattc
      421 atcctcaagt tgatttccac gcaaggatga atccgataaa caggagattc tggaaagcga
      481 cagatcatca tatccactcc caaataacca ttataaatgg ttccgaaacg gagggataat
      541 tcttgttcaa ggcggtcgcg caatttataa atttcttcga cagggatata ttccgaaaga
      601 ttccgttcga tggctgcatc tgaaatcagc agattacctt cgtacgcccc acttccaccc
      661 gtacggaatt gagagtatcc ggcaaaacca aatcgaccat tacccgaaga acgaaattcc
      721 atagcaaaat cttccacctt attatataga ggttcgccaa taacacctcc ttgctggttg
      781 ccaatgcgtg agcaccaacc ggaaatggaa ggagtatata cacctttgca ccaattcaac
      841 ccttttccgc taccggataa aggagctttc agtaaacaag tatcatgtga ttctacaaat
      901 gacttccatt cttcgggaaa cgtcaggtaa aaagactctc cacaaaaaca ggctcccagt
      961 tgtagctgtg gtaataatcc cacagcacag gaacgatggg aacagaaacg cagtttatcc
     1021 aattgctcaa tagaaggaag ctcgctttct tccactccca aatccaacag tcgttttctt
     1081 attgctatat cccagcccca aggacgaata tccaaattcc gctccgaagc aagttcaggt
     1141 tctgtcatca aatcaaccga aagtcctaat aattcctgta tcttcttcac atagtcgaga
     1201 ttataagcgg aaggagccaa tacaacactt ccctcttctg cataccacat cggcaacaaa
     1261 gccaattcgg atgccatctg ccgggcggaa gccggtgcca tatagtttgt ttcaccgctg
     1321 gctaacgcca aatcatgttc cggattgaat atataaagag ccttttttgt cattttaaac
     1381 gaattcaaaa ctttattctg caaatatata caggaaatag tcaggaatgg ctacaataaa
     1441 cagaaagttc taattaaact cacaattttg ccatctctac tttgcaaatc ctaaaaaaag
     1501 cagtatattt gccacccgaa aaacaaagaa ctgaaatgga atcattctat cgcacacacg
     1561 cctacctcgt tgagcacacc aatgcccccg ttcgccgcga tcttatggac gagatcgact
     1621 ggagcgaccg cctgattggt atcaaaggga cacgtggcgt aggaaaaacc actttccttc
     1681 tccaatacgc caaagaaaaa tttgggaacg accgctcctg cctgttcatc aacatgaaca
     1741 acttctactt ctctggccac agcattgtag actttgctaa cgaattccag aaacgtggtg
     1801 gaaaagtatt gttgatcgac caagtgttca aacacccgga atggagcaga gagttgcgca
     1861 tgtgttacga ccgttttcct aatttgaaaa ttgtctttac cggctcatct gtaatgcgac
     1921 tgaaagagga aaatcttgaa ttgcgtgata ttgcaaaaag ctataacctg cgcggatttt
     1981 ctttccgcga atacctgaac ttacaaacag gcatgaaatt cagggcctac agtctcgaag
     2041 aaattcttag cactcacgaa cagattgcca aaggagtact ctctaaagtt cgtccgctgg
     2101 attacttcca ggattacctg catcatgggt tctatccatt cttcctcgag aagcgtaact
     2161 tttcggagaa tttgctgaaa acgatgaaca tgatggtgga agtagatatc ctgctcatca
     2221 aacaaattga actgaaatat ctttcaaaga taaaaaaatt actatatttg ctcgctgtcg
     2281 acggaccgaa ggctcccaat gtgagtcaac tggcaagcga catacagaca tctcgcgcca
     2341 cggtgatgaa ctatatcaag tatctggcag atgcgcgact cattaatctg gtttatccga
     2401 aaggagaaga atttcctaaa aaaccttcca agataatgat gcacaactcc aacctgatgt
     2461 attccatcta tcctgtgaaa gtggaggagc aggatgtact cgacacattc tttgcaaatt
     2521 ctttatggaa agaccataag gtacataaag gagataaaaa cgtctctttt atggtggacg
     2581 aagtaatgcc gttcaaaatt tgccaggaag gagcaaagat caagaacaat ctgaatgtga
     2641 cgtacgcgtt gcataaggct gaaataggtc ggggcaacca gatacctctc tggatgttcg
     2701 gctttttata ttaaaagatt tatttactta aatatttaat ttagttatga ctaaacagaa
     2761 gaaattcatc acttgtgatg gtaaccaggc tgcagcgcat atctcgtata tgttctctga
     2821 agtagctgct atctacccca tcactccttc ttcgactatg gctgagtacg tagacgaatg
     2881 ggctgccgca ggacgtaaga acatcttcgg cgaaacagta ttggtacagg aaatgcaatc
     2941 tgaaggtggt gctgccggtg cagttcacgg ttctcttcag gctggtgcgt tgactactac
     3001 ttacactgct tctcaggggc ttctcctgat gatccctaat atgtacaaaa ttgccggtga
     3061 gttcttgcct tgcgtattcc atgtatctgc tcgtacattg gcttctcacg cattgtgtat
     3121 cttcggtgac caccaagacg taatgtcagc tcgtcagact ggctttgcga tgttggctga
     3181 aggctctgta caggaagtta tggatttggc tggtgttgct cacttggcta ccatcaaatc
     3241 tcgcgttccg ttcatgaact tcttcgatgg tttccgtaca tctcacgaaa tccagaagat
     3301 tgaaatgttg gaaaatgatg atcttgctcc gctgatcgat caggaagctt tggctgaatt
     3361 ccgtgcccgc gcactgaatc cgatgaatcc ggttgctcgt ggtatggctg aaaaccccga
     3421 ccacttcttc caacatcgtg aatcatgtaa caactactat gaagcagttc ctgctatcgt
     3481 agaagaatac atgaatgaaa tttctaagat tacaggtcgt aaatacggtt tgttcgatta
     3541 ttatggtgca gaagatgcag aacgcgtaat tatcgctatg ggttctgtaa cagaagctgc
     3601 ccgcgaagct atcgaccact tggtagcaaa tggcgaaaaa gtgggtatgg ttgccgtaca
     3661 cctgtatcgt ccgttctctg ctaaacactt cctggctgct gtacctaaga ctgccaagac
     3721 tatcgcagtt cttgaccgta ctaaagaacc gggcgctaac ggcgaacctc tttaccttga
     3781 cgttaaagac tgcttctacg gcgcagaaaa tgctccggtt atcgttggcg gtcgctacgg
     3841 tttgggttca aaagatacta ctcctgctca aattctttca gtattcgaaa acttggccat
     3901 gccaatgccg aagaatcact tcactatcgg tatcgtagac gacgttactt tcacttctct
     3961 tcctcaaaaa gaagaaatcg ctttaggcgg tgaaggaatg ttcgaagcta aattctacgg
     4021 tttgggtgct gacggtacag taggtgctaa caagaactct gtaaagatta tcggtgacaa
     4081 cactgacaaa cactgccagg cttacttctc ttatgactct aagaagtcag gtggtttcac
     4141 ttgttctcac ttgcgtttcg gtgatactcc gatccgttcc acttatttgg taaatactcc
     4201 gaacttcgtt gcttgtcacg ttcaggctta cctgcacatg tacgatgtaa ctcgtggttt
     4261 gcgtaagaac ggttctttct tgctgaacac tatctgggaa ggtgaagaac tggctaagaa
     4321 cctgcctaac aaggttaaga aatattttgc acagaacaac atttccgtat actatatcaa
     4381 cgcaacacag attgcattgg aaattggttt gggtaatcgt accaacacta tccttcaatc
     4441 tgcattcttc cgtatcacag gtgttattcc tgtagaccag gctgttgaac agatgaagaa
     4501 attcatcgtt aagtcttacg gtaagaaggg tgaagacgtt gttaacaaga actatgctgc
     4561 cgttgaccgt ggtggtgaat acaagacttt agctgttgat cctgcttggg ctaacctgcc
     4621 ggatgatgca aaagctgaaa acaacgatcc tgcattcatc aacgaagtag ttcgtccgat
     4681 caatgcacaa gatggtgact tgctgcctgt atctgcattc aagggtatcg aagacggtac
     4741 ttggtatcaa ggtacttcta aatacgaaaa acgtggtgta gccgcattcg ttcctgaatg
     4801 gaatccagaa aactgtatcc agtgtaacaa gtgtgcatac gtttgtcctc acgcttctat
     4861 ccgtccgttc gtactcgatg ctgaagagca gaagggtgct aagttcgaac aattgaaagc
     4921 agtaggtaaa gtattcgacg gtatgacatt ccgtatccag gttgacgttc tcgactgtct
     4981 gggttgcggt aactgtgctg acatctgtcc gggtaatccg aagaagggtg gcaaagcatt
     5041 gacaatgaaa cacctcgaaa gccaattggc tgaagctgac aactggactt actgtgctga
     5101 aaacgtgaag actaaacaac atcttgttga tatcaagtct aacgtgaaga actcacagtt
     5161 cgctactccg ttgtttgagt tctctggtgc ttgctctggt tgtggtgaaa ctccgtatgt
     5221 gaaattgatt tctcaattgt tcggtgaccg tgaaatggtt gctaacgcta ccggatgttc
     5281 ttctatctac tctggttcag ttccttctac tccgtatact acgaacgaaa acggtcacgg
     5341 tcctgcttgg gctaactcac tgttcgaaga cttctgtgaa ttcggtctgg gtatggaatt
     5401 ggctaacgaa aagatgcgtg ctcgtatcgt gaagttattc aaccagattt tggaaggcga
     5461 taacgctcct gctgaagcta aagaagtatt gaaggcatgg attgaaaaca tgtacgatgc
     5521 tgacaagaca aaagaattgg ctcctcaaat cgaagctatc atcgaacaag gtatcgctgc
     5581 cggatgtcct gttagcaaag aactgaaagg tctgactcaa tatcttgtaa aacgcagcca
     5641 gtggatcatt ggtggtgacg gtgcttctta cgatatcggt tacggtggtc ttgaccatgt
     5701 aatcgcttcc ggtaaggacg ttaacattct cgttctggat actgaagttt actctaacac
     5761 aggtggtcag tcttctaaag ctactccggt aggtgctatc gctaagttcg ctgctgctgg
     5821 taagcgcgta cgtaagaaag acctcggtct gatggctact acttacggtt atgtatatgt
     5881 tgcacagatc gctatgggtg ctgaccaagc tcaaactctg aaagctatcc gtgaagctga
     5941 agcatatccg ggaccatctt tgattatcgc ttacgctcca tgtatcaacc acggtctgaa
     6001 agcaggtatg ggtaagagcc aggaagaaga agaaaaagct gttaagtgcg gttactggca
     6061 cttgtggcgt tacaacccag ctttggaaga agaaggcaag aacccattcc aattggatag
     6121 caaagaaccg aactgggaag atttccaagg tttcttgaag ggtgaagttc gttacgcttc
     6181 tgtaatgaaa caatatccta ctgaagctga agaactgttt aaagctgctg aagaaaacgc
     6241 taaatggcgt tacaacagct acaaacgttt ggctagagaa aactggggtg ctgaataata
     6301 gtaataccct ataaatataa agcggtaatc tttgataaga ttaccgcttt tttattgtat
     6361 gaactctgtc caacataaac agtactccct ttttcccact agagttcatg tctattttat
     6421 atttaaaatt aaaaataaca atgctccaat ctatttattc tctgacttcg gaatccaact
     6481 atccaccaac agccgatgct catccctcca tttgcgggct atttcttctt catccatccg
     6541 ggcatccttc atagctgtca taaaagagct aagttcttct gtcgttagtt tgatgttgcc
     6601 aaagaattcg gcagcaaacg gatctttctc actgaatcct ttccatgcaa tagcatgtat
     6661 ttcttccaag tctccatata ctttcttcgg atcatccaag aatttcaaat aaaacaggtc
     6721 aaacatccaa tgtggtgtcc accccgtgat gaccatccat tctcctttat ccatcgcttt
     6781 tttcaaagaa gccagcatgg tggaactact tgaagtcatg agggtatacc catcaagtcc
     6841 gtaagcagca atggccttat cggtcgtctt cattatccct gctcccgcat caattcctac
     6901 tatttcagaa gagaaacggt ctttattagc ttccagctca ctaatagact ggatcgtaac
     6961 atattgagga acaactagtc ctacacgggc ctctccatat acctcaccca gaaattcgat
     7021 actgtctcca tactgatcca tataatcttt catcgttatt ggtaaccatg catccagaaa
     7081 cacatctgat ttctttcctg acatagatac aaaaataggg gcaagatcag cattttgcaa
     7141 ttcaacctca tatccatgct cttccaatac caccttagcc aaatgactca tggcaatacc
     7201 ttccagccaa ttggcatagg ctatttttac tttctttttc tctaagtctg aattagtaca
     7261 ggaagctagc aaaagcatag ctgacaatac tattcctact attttatata ttctcatacg
     7321 tattttatcc tttccgttta gttcttattt tttcgtcctg ccattccttg cgtgatacgg
     7381 tctaagatga tagctaaaat aacaactgct ataccacctt caaacccaag tccgattttc
     7441 atttgggtaa tacctttcaa tacaatttct cccagaccac cggcagcaat catggcagca
     7501 attacaacca tagaaagcga catcattatt gtctggttga caccagtcag aatggtgggc
     7561 aacgccaaag gaagctgcac tttatacaat aactgccaac gggtagctcc gaacgaacgg
     7621 gaagcttcca ctacattttt aggaacttgc cggattccca atccggtaag gcggaccaca
     7681 ggaggcatag caaagataat ggtggcaaac actcctggca ctgctcccaa tccgaaaaac
     7741 aaaacagcag gaatcagata aacaaaagca ggcatcgtct gcatcaagtc gagaacagga
     7801 cggagtattt tctctgcacg cgaactgttt gccgtccata ctcctaaagg tacaccaaca
     7861 atcagggcca gacaggtaga tgaaaaaacg agagctagag tttgcatggt agcctcccag
     7921 aatcccattc catagatcag taataatccc aatgcggtga aaattgccgt accgcgtcct
     7981 gctttcatcc atgcgagtgc agcaagtacc aaaatggtta tataaaaagg tattccgaaa
     8041 agtatgtgtt ggaatcctat aataaaacta ccgatgcccg cattcacggc atcaaagaaa
     8101 gtggaaaaat gtatcatcat ccaattgatg gccatctcta tatattgtcc tatatttatc
     8161 ataaatctat tgcgttttga attatttcgt ttatttcttc tttatctttc ccggtcactt
     8221 cgatgattaa ggatgaaagc gggattgttc ctaaaaactc gcgcgtctca tcaatcaccc
     8281 ataccggcga attgctcttt gtcattagag gaagtatatc ctccaacacc gtatcctcca
     8341 acacagaatg tacttctgta cgcacaatcg tttcaatgga tttttcctgt ttgctacgta
     8401 acttaagcaa gtcgttcaga cgtacttctc cgaccagttt atcatcggcg tctatgacag
     8461 gtaatacggt gatattcttc gcacgcatct tacgaatcaa tacttcggga ccttctttct
     8521 tcagacgggc caccaacggt ttgtcaatca ttaaagaaga ggcggtaata attttgctcc
     8581 tatccacgtt ttcaacaaaa cgggctacat aatcgttagc cggttcagtc aggatttcct
     8641 ccgaagtacc tacctgcacc acttctccgt ctttcatgat ggcaatacgg tcacctagct
     8701 taattgcttc actcaagtcg tgggtaataa aaacaatcgt ctttttcatc tttgattgca
     8761 aggccagtag ttcatcctgc atctgtacgc gaatcagagg atcgagagca gagaaagcct
     8821 catccattaa aagcacttca ggattattag ccagagcgcg agccagtccg acacgctgtt
     8881 gcattccacc ggaaagctcg cctaccatct gattttcata tcctttcaat ccgacaagct
     8941 tcatgctttc catcgctttc ttctcacgtt cctctttctt cactccctga agttcgaggc
     9001 cgaacgcgat attgctcaat acggaacggt gaggtaacag accgaaattc tggaaaacca
     9061 tcgccagctc tttccgacga acctgcaata attctttttc ggaaatttta gatatatcta
     9121 ctccgtttac aagcacttgc ccggtagtag gacgtatcag acgattgata caacgcagta
     9181 atgtcgattt tccacttccc gagagtccca ttatcacgaa aaactctcct tcattaattg
     9241 aaagattggc atctttcact cctaccgtac aaccggtatc tttcagaatt tcctctttac
     9301 tcttatcttt tttcaacatc ttgagggctt tctgcttctc gttaccaaag ataaggtaca
     9361 aatcctttat ttctatttta ctcatataat atattggttt agattataat atttgttttg
     9421 ttttcaactg ccgcattcct tattctcact tacgataaac aagttgaatg ttcgcatggt
     9481 tcagtcatgt cacatgataa catgacggtc cgacgttttt taaatggtta aaaaaaacag
     9541 acagagtagt ttaaaaggaa tagaatttga taagattatc ctcttaatga acagtagaaa
     9601 acagtatttt cataaataaa taacagtctg ttcttgcata ttgttggcac aaaggtaagg
     9661 aaaatagatt aaatatgcaa atttcattca ggtacggagt aattccaaag atgctttttc
     9721 aagtctacgc atccattttg tttgaaagag atcccttctt ccaacaagag ttgtttctgc
     9781 tctgtccaac ccggaacaag ccgtcccgac gcattgacaa cccgatgaca aggcgcagat
     9841 aaatcatccg gaatctgttt caaagcacgc cccaccatac gggaacattg agacattccc
     9901 aataatgcgg caattccccc ataggtagaa actttaccta ccggaatttc tcggacaacc
     9961 tgatacacct cttgacaaaa ggatgcggaa aggctcgcct tatctacttt ataatctttc
    10021 atcactcaaa cattacttta tttcagttcc aaaactagat aaaaagaaaa gaatttgcaa
    10081 ataataaaag catttcaaat aaaatatgca actttatttg ctttatttac aaataatccc
    10141 gacctttgta cccattaaaa gcaaccctat tattaacaaa acaagcactg ctgttatgaa
    10201 aaagaaaact atcctgttcg cttcttgttt attgggagca ctggctttca gctcctgtga
    10261 gaagaacctt tatgatgaaa gtaaacaacc cgagaaagaa aagaagatga ctgacttgga
    10321 agtacctgcc gatttcgact ggaaaggttc tcaaaatgcc aaagtgaaaa ttgccagtca
    10381 atcaactgct actatttctg tatttctaga agaaaattgc aatgaagagg ctttgatgct
    10441 tcgaatggat gtcgatgcca acacatcaaa attggaactc ccaattgaaa ttcctgcata
    10501 tataaaaaat gtgtatgtaa aatatggtaa tggctctgaa atacaaactg ttcctgttga
    10561 aagtaatggt actatttcta tagtagtacc tgctaacgct acggcattat ccagagttac
    10621 cacaagagct aataaagaag ttgaaacgaa caacatcttc aattatccgg gatatggcaa
    10681 cggaactatt atgttcgaag atatgtatcc agctttaggc gattatgatt ttaatgattt
    10741 tgttgcatgg tataatttcc aaattgacgg tttttattgg agtcacaatc aatgttatgc
    10801 agaatactta atgataggat tccaaatcag agctatagga ggtatatatg actacaatct
    10861 ttatatccgc ttggcagaag tacaatataa tgaacttgat ttagaagaaa ctcaaatgta
    10921 tcttgagcgt aacaatcctg aagaggctga aaatatcaaa atcctaaaag gcccaaaagg
    10981 ggaattgatt atttcactaa agaaaccggc cattcctaac ggatacaagt attataatac
    11041 ggaggtaaat gaaaaaacaa agcctaaaaa aatgatggcc atttacttgg tgttcaactc
    11101 acctgttaac gttaaaagcc tacaagacag taaaatggac ttttatattg caaaaactaa
    11161 taaaggacaa gaaatccact taaaaggtta tagcccggtt tattataaca gcaacgaaag
    11221 ttatgtaaat gaagacaact ttatatgggg attaaaagta cctgcatctt tacatcatgc
    11281 cagagaagaa gtaaacttct tggaagcata tccagacttt gaacaatggg taacatcggg
    11341 aggtcaagag aaccaaagat ggtggaataa gccaaaaacg aataagttga ttatgaatta
    11401 ataaatatac agtaaatcat atactgaatt aaataagagg taaggtatgt caatagattt
    11461 ccttacctct tatttttatc atatgaattc catagaagta taaacagata aatgctcacc
    11521 accaaatttt gcagattcta tcctatcctt tcctcttcaa caaatctgtc ggactctctc
    11581 caaactgttc tctataacat ttagtaaaat aagaaggaga actaaaacca acttcataac
    11641 cgatctctgc cactgtcata tccgacgagg caagcagaga ggcagctttc ttcaaacgag
    11701 ctatacgaag cagttcattc ggagaataat tagtcagaga tttaatcttg cggtaaagtt
    11761 gcacacgact taatcccata tccttaccca aatcttctac attcaaattt gaatctccca
    11821 tctttgcctc aatcagagct ttgaattttt ccacaaagtc tttatccata tcacagacat
    11881 cctctttcgc caacgtttgt ccgtcaccaa aaaactgttt caggcggcgg tgtgaatcta
    11941 tcagattacg aacgcgtgcc aatagtaatt gcgaactgaa aggcttggag atataagaat
    12001 ctgcaccacc atcataccct tgaattcgtt gttcatccaa agaacaagct gtcaatagga
    12061 taacaggaat atgacaggtt tgtaattcgc ttttcaagcg acgacaacat tcaattccat
    12121 ccattccggg catcattaca tcggagataa tcaagtccgg gacatatttc atagctttac
    12181 gaataccttc cgagccgtat gcagcttcta taacagtata atcagtgtga agcaatccat
    12241 gcacatataa gcgaatatca gcgttatcat caataatcag aacgcaaggt ttggaagagt
    12301 cgtaactttt ttccaattcc tcttcttcgt aagttaaagc atcattcaag ctcgaagaac
    12361 cggaataacc agaagttgca ggagttacgg gagccccagc aacggcagag gttgcagcat
    12421 cggtagaggt tacagaagta gcaggcacag agaatgccgg agagttttct gaaacaacag
    12481 tctcgcaagt ctgtacaggc aaatcaacgg taaagatagt tccttgcttt tcatcacttt
    12541 ccaccgtgat ggtaccttta tgcaattcca caaaagcctt taccaatgcc agtccaatac
    12601 ccgaaccggc atggtgcata tctatcttat agaaacggtc gaaaatattc cggatatgct
    12661 ccgcagaaat cattgagccg gtattggcaa cagtaaagcg aatccaacaa tgatcgtctt
    12721 tagtcaggga agataagcgt acagttactt ttccattctc tggagtaaat ttgaaagcgt
    12781 tggaaaggag gttgaaatag atgcgttcca acttttctac atctgccaat gtgcggtaat
    12841 ccgtatccgg catataatcg aatgagaaat gaatatgttt cttccgggct gctgccatga
    12901 aagactcgtt ccatccctca aaagaagaaa gaatgtctaa cgaaatagga gtatattcca
    12961 tttttccatt ctcgtattta cgaaaatcca gaatctgatt gacaagacgc aagaggatat
    13021 tcacgtttcg ctgaactaac aataacattc ggcgctgatc ttcactcaaa gacgaatcag
    13081 ccagtaaatg ctctaccggg tcggcaacta atgtcagtgg agtacgaaaa tcgtgagata
    13141 tatttgtgaa gaaaaccagc ttggcatgag tcgcttcttc cagttgatga gaaagctgga
    13201 taagctgatc ccgctgttct tcgagtttgt cacgctgttc ttcaagaata tcccgttgct
    13261 cttcgagttt atcgcgctgt tgctctactt gtttcttctg ttcggacaac tctttattca
    13321 ggcgattctt ggaacggagg gatttataga ctaccaacaa caatcccgct actaataaaa
    13381 gaataaccaa gccgccatac atcacgacct gctgcgtagc tacacgcgac agatacccac
    13441 cgatacgtcc gttcaatgtt tcaatcttct gatccagttc cgagatatgg gtagtctgaa
    13501 gttgcataac gtgcgcgttc gtgcggtcta caacggcagt attcatgacc gtttcgcgag
    13561 gataagactt cttctcaaga atattcatgg ccagttgcat cactttgtcc ccattagtcg
    13621 gataaataaa agttgcatcc agcacattgt caagcaccaa ttcaagcccg tttcctttgc
    13681 cgggcagggc atcaatgcca acaaaaatca tttccttttc acgtccggct ttcttcgcag
    13741 cttgataggc tcccggagcg atacggtcgt tatgtgcata taccgcatca atcttcggat
    13801 gacggcgaag catactatcc atttccactt ctgccggttc acgttcccag gcagcatccg
    13861 ctttatcaat cagtttgata tccggataat tgctgatagc agccataaat ccctgatggc
    13921 gttccatggc aggggtggaa ccacccagtc cggtaagctc cactacattc cctttccctt
    13981 tcagacttga tgcgatataa tttcctaccg cacgacctat ttcataatta tcggcaccga
    14041 tataggcagt atatttatca gaaagtatct tccggtctac aagaatgaca ggtattcctt
    14101 tctgataggc ctcctccaca attggagtca tgggagccgc ttcattggcg gaaattatca
    14161 gtaaatcaac tcctttatct ataaaataat gaacatcttc cgcctgctta cggttatcat
    14221 ccgccgccga gcggatttca accgacactc catcataaaa catcgcttcg cgaagaatct
    14281 catcattcat cttgtgccgc caagagtcat cactacattg ggccacccca atacggaaac
    14341 gaggcgcatc ctgacgacag gccgccaagc ccaaaagaca aaacaagact gttatccact
    14401 tcatatattt catcgcttca atcattccct ttctttcgta tatcttttgt atttctttct
    14461 gtaatccaaa tttctctccc cgcattattt gcattcacca ccgggaaata catcagttcc
    14521 actttcacag ggttcagcgt gtattttcca gtaaagcgtg aaagcaaagg aaccgtaaac
    14581 tgataagtac ctaccggtaa tttttcgcta aagataacag ttttctcttt aaaatactca
    14641 cgatatactt cagaacggga gaaattaaca ggttttgagg cataactaca acctgccgga
    14701 acaggaactt cgagcatcac atattgcgca ccctcctgtt tcacctgcaa ggtaactgtc
    14761 aatgtaacag gtacacccgc caccaaagag tctttttcca aagtcgcctc caccttgaaa
    14821 gcatcactct gacgagcatt catcacacgc ttcattgaat agacactata caataaaggc
    14881 tcttttcccg tttttgaaat aagcagactg tcgcctgcta tcagccgggc atgataagga
    14941 aattccgtaa ttcgttgatg atccttaccg ctcacagaca ccgacgttcc tgacatccct
    15001 ccggaacctg ccagcaaatc ggtcagaaca gttgccacag ccgaagaagc ctgatacgta
    15061 ttccatccgc gctccttagt ccgcaaaata tacaattgca tattttcttt caacttacac
    15121 agggaagggt catttttaat aatccggtag gctatcaatg tatttatcat ctgatttccc
    15181 tcccaataat aagtacgccg tccgtcgtca cagtaaacac cttccagcat atcctttttc
    15241 agataaggac gtacgctatc acccacattc accgaatcca cctgttgctt gatttcccag
    15301 agaagcagct tctctttcaa gtatgaaaga ggacgataat acttgtttct atttgccaac
    15361 gagtcttctt tctgttccaa ttgccggacg aaaggttcca ataatctgac tgccgaagaa
    15421 taatccgcct ctactttcca ctcatgcaga gcatgaagta tttctatatc ttccagtttc
    15481 attcctcgat aaggacgcgt atgagcatac tccactttca aaccattcag attcaactcc
    15541 acaggataac ctgcatcttg cgccatcttc aaagcccgca gaatatgcgc agacatccag
    15601 aaagaagtat tttcagagtt cccccaccac gaccataact gatgtttgtt ctgatgattc
    15661 gtcagtcgat ggatgatagg tcgaattgct ttatctactt tcaccttttc acccttactc
    15721 tgcatatact gttggtaagc caacaaaccg attaacttgg atgccagctg ctcattgcac
    15781 aaatatttgt atcctgtcaa gtaattcact gattctttat agatgtccaa ctgattgtca
    15841 gtgatactca ccatcacttc ttcatcctcg ccggattgca ctttgaccgt ctttgcatcg
    15901 gacagaatac ccaatgtgcc ctccgccaat tcagttccct gtggcagtat cggaatcgta
    15961 tattcctctc catcctgata gccatcgtcg cgagtgaaaa gatagctgat ggtcacgcta
    16021 tcggcatgaa ctgcctgcat cggcactgtt tcatgaaatc cctccatgaa actcacttcc
    16081 tgccgtttca acgtatccgt tccgacgcag aactgtgtct ttccggctat gtgctgccca
    16141 tccagataat tgcggatagt cccaaccacc gtactctgat ccccctccac caggaagcgg
    16201 ggagttttca actccgccat caacggtttg taagagcgga tggaacgtcg gaaagtaccc
    16261 gtctgcaaac gacggttcat gccataaacg acagtttc
//
