LOCUS       c00105_gnlPro..        15544 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LKHHKEIA_110.
ACCESSION   c00105_gnlPro..
VERSION     c00105_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 23:43:43
            Original ID  :: gnl|Prokka|LKHHKEIA_110
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15544
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15544
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9038:13898]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9039..13898
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15544
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15544
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(3..2438)
                     /locus_tag="ctg105_1"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAEDGYAQRTRVAISMNNVSVEQVLNKIEE
                     TSDYVFLYNDKTIQKNRIVSVRNNSGKILDILDEVFKGTNITYTVVDKQIILSTNKLNV
                     TEQDPTIQVKGTVKDTKGEPLIGVNVKVKGTTTGAITDFDGNFQIQAKKGAVLEISYIG
                     YASQEVKVTDNKSLSIVMTEDAKVLNEVVVTALGIKRETKSLTYNVQQIGGDEVAKAKD
                     MNVMSSLAGKVAGVNINASSSGIGGGARVVMRGTKSISGNNNALYVVDGVPLANISGEQ
                     PDDQYTGAGQSGDGLANFNADDIESISVLSGSAAAALYGSAAANGVVLITTKKGAVDKT
                     RLTYSNNSTFYSPFRLPEFQNTYGSETGEWYSWASKLSSPTDYEVKDFFQTGYNVANTV
                     SLTTGTQKNQTYVSVGAVNARGIIQNNDLDRYNFSVRNTTSMLNDKLTMDLSFMYSNVK
                     EQNMLSQGEYANPLVPVYLFPRGDDFSKYQYYERYDVDRNIKTQFWPLKENGLSMQNPY
                     WITNRNMYTNKKDRFLASGSLKYTITDWLNVSGRVKLDKETINSEKKMYASTLNVIAEN
                     SDKGAYVQSNKNTSQIYADAMLNINKYFYHDTWNLTASLGASLLDLDYKELNFGGGLLT
                     IPNLFTSNNANVSGKLTYKNTNYHDRTNSLFGTFSLGYKGMVYVDGSLRNDWISALAGT
                     NHSSILYPSIGASAILTNMFTMKSNILSYAKVRLSYSEVGNAPERFRAITTYAVLGGLN
                     TTSYFPIKDLKPERTHSWEGGFNLGLFDNKLTLDVTAYKTYTENQLFSPEFLQQPDILN
                     "
     CDS             2539..2709
                     /locus_tag="ctg105_2"
                     /transl_table=11
                     /translation="MNYGLIPASVCETLYRESGKFGGRQLLVAAFFLSFILLCYSMGFY
                     FKGYYSNINLL"
     CDS             complement(2690..3601)
                     /locus_tag="ctg105_3"
                     /transl_table=11
                     /translation="MSPESLLRKAQALGDDIKEMESIDVLGAYYQAQTTIKTNRRKNMY
                     NQLMRYAAFLTIPLFLSSLVLGYLYFSGTETDEKYAEVVTATGSVIRYELPDHSVVWLN
                     AGSTLRYPTTFKKDNRLVELKGEAYFEVQADKDRPFYVNTPNGLSVYVYGTKFNVAAYE
                     DDNYIETVLEKGKVNVITPDQETIVLAPGEQLLYDKQSQKSKKNKVDVYGKIAWKDGKL
                     IFRNASLEEILKRLERHFNVEIQFNNRSGKEYKYRATFRTETLSQILDYLARSADLKWK
                     IEEPQQQADDTLSKTKIRVDLY"
     CDS             complement(3705..5696)
                     /locus_tag="ctg105_4"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHSQGVSKSFIPMAEIPAGSFYMGSDGLGE
                     DFDEAPIHQVIISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYAPYSAEKQKDPAGPLTGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQKSVENTSIKWKKVS
                     AITPMFLPPIPFVVRPVCDSNTPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMVVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGVEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDGG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLGNGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYVASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
     CDS             5870..6433
                     /locus_tag="ctg105_5"
                     /transl_table=11
                     /translation="MKISFSKQTKERAFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKLDTDSFDLQSNTALAYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPVYET
                     EPDSIYTLDELYRMLYETLNKLPENYRTVFIKSFFEGKTHTEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKEYMPLLLLLFLRA"
     CDS             complement(6806..7345)
                     /locus_tag="ctg105_6"
                     /transl_table=11
                     /translation="MTETLSHIALRRLNGASASEHYYPFPSVKLSLSAENTLIIDAPLV
                     CDETLQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKLLRPFIPVSFVITSVP
                     DQRLGQAVTLLLADQPDTEEIGNKLHEILEPYYRPKHILTIESIPQTENGKINRAECRI
                     LAKQMLMTFYPHTLTP"
     CDS             complement(7444..7920)
                     /locus_tag="ctg105_7"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEDISQLIAGGAEAHSSAYWDLYLFLN
                     EWFNGSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTMQVPEEKER"
     CDS             complement(7952..8977)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg105_8"
                     /sec_met_domain="MR_MLE_C (E-value: 4.8e-30, bitscore:
                     94.6, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRLLHFKQPAGTSRGIYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILKRICRQVEKEQGMWDKDVLCQYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIPINGLIWMGDFDHMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGCNTLEEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             complement(9039..9863)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_9"
                     /sec_met_domain="ECH_1 (E-value: 1.3e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(9867..11534)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_10"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.4e-08, bitscore:
                     21.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYAVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVVISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDALPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIDQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPDYPRVWENYCKIIPEPEFAYSEMLAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTSGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNINVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELTEAM
                     KTFTQPETMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(11554..12669)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg105_11"
                     /sec_met_domain="Chorismate_bind (E-value: 2.4e-57,
                     bitscore: 184.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSETCPVVLIQPDQWGQPLPIDNDTAEEREVALRMQGQES
                     FLTSSTEEYASCFHTFINALRDNTFDKLVLSRHLTIDKVSGFSPLSIFRAACRRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLGIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYRFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIKDEQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIATPPLKS"
     CDS             complement(12666..13898)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_12"
                     /sec_met_domain="HBT (E-value: 2.1e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNDLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     LGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLGMKREEVIAVGDGV
                     CDVTMIQLAGLGIAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIISEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(13982..14344)
                     /locus_tag="ctg105_13"
                     /transl_table=11
                     /translation="MIQVRIKRVYEDFSETDGYRVLVDKLWPRGMKKEWLKYDYWAKDI
                     TPSPTLRKWFHEDIPGHWGDFVTQYQKELDASPSMADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMRLRE"
     CDS             complement(14409..15446)
                     /locus_tag="ctg105_14"
                     /transl_table=11
                     /translation="LAYISYLEKKYTQAEGYYQKYLAIKESHTPDGKMYSIPYLILSKQ
                     YETVIDNCKDFKELLRTQRDTLNAQYLTILNKEVQAYLGLNRYKEAAEIRETIIAITDS
                     INSTDRKNAALELNAMYGASEKEEYIAEQASQLKIRNVSLCFLACIVVLTLFILWRLWR
                     FNHIIEYKNRMLAKLINEKFANKKDGNQLLEVYEEQEVSSELEPELISPEEQDELLDET
                     DKESGEEEENKKIFQELNHTVVQKQLYLSPELSREDLAQIVHLNNARFARMIRECTGTN
                     FNGYINGLRINYAIKLMKKYPNYTIRAIADESGFNSAPILYNLFKKKTGMTPYEFKKAQ
                     DTLRN"
ORIGIN
        1 taatttagaa tatccggttg ttgtagaaat tccggactga agagctgatt ctccgtatat
       61 gtcttataag ctgtcacgtc cagtgtcagt ttattatcaa acagacctaa attaaatcct
      121 ccttcccatg aatgagttct ctccggttta aggtctttta tcgggaaata agaagtggta
      181 ttcaatcctc ccaacactgc gtacgtagtg atagctctga atctttccgg tgcattaccc
      241 acctcactat atgaaaggcg aacctttgca taagaaagaa tgttagattt cattgtaaac
      301 atattagtca gaattgctga agcaccgata gaaggatata atatggaaga atggtttgtt
      361 cctgccaaag cagatatcca gtcattacgt aacgaaccat ctacataaac catgccctta
      421 tatcctaatg agaatgttcc gaataaagaa ttggtacggt cgtgatagtt cgtattttta
      481 taggttaatt taccggaaac attcgcattg ttagaagtaa acagattagg aatggtcagt
      541 aatcctcctc caaaattaag ctccttataa tccaaatcca ataaactggc acctaaagat
      601 gctgtcagat tccatgtgtc gtgatagaaa tatttattga tattcaacat ggcatccgca
      661 tatatctgac tggtattctt gttcgattgc acgtatgctc ctttatccga gttttcagca
      721 atcacattca aagtggaagc atacattttc ttttccgagt tgatagtttc cttatccagt
      781 ttcacgcgtc cggaaacatt caaccaatct gttatcgtat attttagtga accgcttgcc
      841 agaaaacggt ctttcttgtt ggtatacata ttccggttcg taatccagta aggattctgc
      901 atggataatc cattttcttt caatggccag aactgtgttt ttatgttacg gtctacatca
      961 tatcgttcat aatactgata tttcgagaaa tcatcaccgc gcggaaataa ataaacggga
     1021 accaatggat tggcatactc tccttgcgac aacatattct gttcctttac attagaatac
     1081 ataaaactta aatccatcgt cagtttatca ttcagcatag aggtcgtgtt acgaacagag
     1141 aaattatatc tgtccaagtc attattctga atgatacccc gggcattcac agcacctacg
     1201 gatacatagg tttgattttt ttgtgtccct gtagtcagac ttacagtgtt tgctacattg
     1261 taacctgtct gaaaaaaatc tttaacttca taatcggtag gagatgacaa tttagatgcc
     1321 caactatacc actctccagt ttccgaacca tacgtattct ggaattccgg caatcggaat
     1381 ggtgaataga aagttgaatt attactgtaa gtcaatctgg ttttatctac agctcctttc
     1441 ttcgttgtga taagtaccac accattggca gcagccgaac cgtatagtgc agcggcggcc
     1501 gatccgctaa gtactgaaat tgattctata tcatcagcgt tgaagttagc caatccgtca
     1561 ccggattgtc cggcacccgt atactgatcg tcgggttgtt cacctgatat attagccaaa
     1621 ggaactccat ctactacata tagagcgttg ttattacctg atatagactt cgtaccacgc
     1681 attaccacac gggcaccgcc tccaataccg gatgaacttg cattgatatt cacacccgcc
     1741 accttaccgg caagactgct catcacattc atatctttcg cctttgccac ttcgtcgccg
     1801 ccaatctgct gcacattgta tgtcaaagac ttggtttcgc gtttaatgcc caaagccgtt
     1861 acaacaacct cattcaagac ttttgcatct tccgtcatca caatggaaag cgatttatta
     1921 tctgtaacct tcacctcttg agaagcatat ccaatataag agatctccaa taccgctccc
     1981 tttttagctt gaatctgaaa gtttccgtcg aaatctgtaa tagcaccggt agttgtccct
     2041 tttactttca cattcactcc gatcaaaggt tctccttttg tatctttcac tgtacctttt
     2101 acctgaatag tcggatcttg ctctgttaca ttcaatttat tggtagacaa gataatctgc
     2161 ttatcaacca ctgtataagt aatgttggtt cctttaaata cctcatcaag aatatccagg
     2221 atcttacctg aattgtttct cacagaaaca atacgattct tctgaattgt tttatcatta
     2281 taaaggaaaa catagtcgga cgtctcctct attttattca gtacctgttc tacagataca
     2341 ttgttcattg aaatggcaac ccgcgttcgc tgggcatagc catcttcggc agaaagttgt
     2401 aatactactg cgaaaagtag tgctagacta atcctcataa ctaaaggaag ttttagattt
     2461 aaagcatatt taggacataa tgctgtaaat gaatgatttt ttttcataca tttgtggcta
     2521 actaaagttt attactaaat gaactatggt ttgattccgg ctagtgtttg cgagaccttg
     2581 taccgtgaat ctggaaaatt cggaggaaga cagctgttgg tagcagcttt cttcctttct
     2641 tttattctct tgtgttattc catgggcttt tattttaagg gttactactc taatataaat
     2701 ctactctaat tttagtcttt gataatgtat catctgcctg ttgttgcggt tcttcaattt
     2761 tccattttaa atcggcagac ctggccagat aatccaatat ctgcgacaga gtttcagtcc
     2821 ggaaagtagc ccggtactta tattcttttc cagacctatt gttaaactga atttctacat
     2881 tgaaatgtcg ttccagacgc ttcaggattt cttctaatga agcatttctg aaaattagtt
     2941 ttccatcttt ccaagctatc tttccataga catccacttt attttttttc gacttttgac
     3001 tctgtttgtc gtaaagcaac tgttctccag gagccaatac gattgtttcc tgatcggggg
     3061 ttatcacatt taccttaccc ttttccaata ctgtttctat ataattatca tcctcataag
     3121 cagctacatt aaatttggta ccataaacat atacgctcaa gccattcgga gtatttacat
     3181 agaaaggacg atctttgtct gcctgcactt cgaaatatgc ctcacccttc agttctacca
     3241 accggttgtc tttcttgaaa gtggtaggat aacgcaatgt actacctgca ttcaaccata
     3301 ctacagaatg atccggaagt tcataacgta tgacagaacc ggtagcggtt accacctctg
     3361 catatttctc gtcggtttct gttccactaa aatataaata tcccaaaacc agagaagaga
     3421 gaaataaagg tatagtcaga aatgctgcat aacgcatcag ttgattatac atattctttc
     3481 ttctattagt ttttattgtg gtttgtgctt gataataggc acccaataca tcaatggatt
     3541 ccatttcttt aatatcatct cccaatgctt gtgctttacg gagcaatgat tccggactca
     3601 tattttccat attttctttc aaaatcttat cttttaattg taattacact tataatacaa
     3661 ctgaagtaat tggaaaagga cagcaaaaac aaactttttt tattttattt ttcgagccat
     3721 gccaaattga agcggtaatg caatcggcta ctaaggatat gaaccacatt atcaggagtt
     3781 tgtgttcctg caagatagcc acgtggttca gcatgatttt catccatttc gaaatatccc
     3841 gtccatgctc caccgtttaa aaaacgatat tcaccgtccg tcagtagttt tcttaccggc
     3901 catgtttttc cctcatcgta ggaaagagcc gcatacatgc catatccttt cttcacattt
     3961 ccatttttat ccttaaattc cagaccacgt tcttccaaag gcgtacgttg cggatggtct
     4021 gtgaaagaaa ccaatagcaa aggtccttca ttcagtctca ttaaaacaag acgctgacct
     4081 ccgtcaatag gagggagttc gcttgctaca tatttccagg tctttcccat atcatctgat
     4141 atgctcattg gcattcggag ctttccttct ttattccgta tgctattacc acgccccata
     4201 gccatcaaac ttccgttccc taattgtaca attcccgcat ggatacctgc gattgtactt
     4261 cccgttcctc cttctttgaa atccggcaaa ggagcgccat cccaaggatc gcaccatgtt
     4321 tttcctccat ctttactgat ttgaacagct gccccgtcat gactgccggg acccgcatca
     4381 caggcttgaa ccagccatcc ctcacgtgtg cgaatcgtac cagctattac ctgatgacgt
     4441 ttggtatgtt cgggagctat cagtttagga gtgctccatg aagcaccgtt atctgtgctg
     4501 gtacgtagta ccattgcgag attctgccag tctcccgatg cttccactcc attgatatga
     4561 tacaattttc ctttcccgtc attgagcaaa gcgcttcctg tcatattccg atccggaact
     4621 ttaaagaata aagaagccac atcccaatca gtgtgcccgg cacgcaagcg ggaaccgagt
     4681 actaccatcc ctctcccatt ctcttcattt gcagaaaacc atattgccag caaatctcca
     4741 ttatcacacc acgtaactgc aggctgatga ttatgcagat aaaatggggt attcgaatca
     4801 cataccggac gtaccacaaa tggtatcgga ggcaaaaaca tcggtgtgat agcagatact
     4861 tttttccatt ttatagatgt attttctaca gatttctgat tgaacgggac aggggcagat
     4921 gttcccgata cattcaaacg agtatctgct tccacaattc taaatccggt ttgggaatgt
     4981 ttatcttccg ggagcatagc cagtcgattg gcacttcgca agtatttctc cggggtgtga
     5041 tgactccctc ctcgagtgac ccgaaactct ccggtcaacg gtcctgccgg gtctttctgc
     5101 ttttctgcgg aataaggagc ataccaatcc aagcaccatt cttccacatt tccatgcata
     5161 tcataaagcc cgaatgtatt aggaggagtc tgggctactt ttaaagatac cggatcaaag
     5221 tcacgaacca ctttttgatt ccgatgataa actgcaggta acccgtctcc tgtagaaaat
     5281 agtgtgtatg tgcctgcccg acaagcatat tcccattccg cttctgttgg caaacgatag
     5341 tttttgcctt ctttccggct aagccattca caaaaggcaa cagcatcgga ataactcaca
     5401 ttgacgactg cttcatcatc ttccagcgaa acaccgtttt ttcctcgtaa tgcccgatgt
     5461 tccggacgga atgattcata ttgcgcattc gttatttcag tgattcccat acgaaacggg
     5521 cgagagatta ttacctgatg gataggagcc tcatcaaaat cttcgcctaa tccgtcactt
     5581 cccatataaa aacttccggc aggtatttca gccatcggaa taaaagactt ggaaactcct
     5641 tgagaatgta ttggcaaaca aaaggttata gccaataaaa aaaacttgtt tttcatattt
     5701 taatcccgtt tatatataat acaatcaacc tatatacaaa aggacagcct catctgatta
     5761 ttttctattc attagtgttg aaagcaaaaa aaagaatcga aaattaggct ttgataatta
     5821 tcttattata tatttgcaac gaaatgaaaa actacagaac ctcaaaataa tgaaaatatc
     5881 tttttctaaa cagactaaag aacgggcttt caaacaactt tatgaggagt attatgcccc
     5941 attttgtttg tatgcaaaaa ggtttgttga tgataaagaa acacgtgaag acatcgtttc
     6001 ggatgtattc acctcattat gggataaact ggatactgat tcttttgatc ttcaatcgaa
     6061 caccgcatta gcttacatca aaatgtgcgt aaaaaatagc tgcctgaatt tcctgaaaca
     6121 tcaggaatat gaatggagct atgcggaaaa tatacagaag aaagctcctg tctatgaaac
     6181 agaaccggat agtatatata ctcttgatga gctatacaga atgttgtatg agacattaaa
     6241 caaacttccc gaaaactatc gaacggtctt tattaaaagt ttctttgaag gcaaaactca
     6301 tacagagatt gcagaagaga tgaatcttag cgtgaagtct atcaatcgat ataaacaaaa
     6361 aacgatggaa cttttacgta atgaattaaa ggagtatatg ccactattac tcttgttatt
     6421 tcttcgtgca taatctacat cctcatgttc tcttcctggt atatgccttt cttttgaaaa
     6481 acagtcgtac tctatatatg tattagtcct gttgtttata tcactctgct taatagttag
     6541 caggggctta cttgtgtgga cagataagct atcagttgtg aacaaatccg tttacggttg
     6601 taaacagatt tgttcacatg ggtgagccct tgtaaaacat tagagcttaa caaaagaata
     6661 cctaagtatc aatgtatgat atatagggaa atatagtata aattagctgg gaacaagacg
     6721 agccagggtg agggtaactt tttaccctca ccctggcctc acctctaccc tcacacttga
     6781 aacaccgatg aataaaggga ttgaatcaag gtgtgagggt gtgagggtaa aacgtcatca
     6841 acatttgttt ggctaagatg cgacactctg cccggtttat ttttccgttc tctgtttgcg
     6901 gaatggattc tattgtcaat atatgcttgg gacgataata aggttccagt atttcatgta
     6961 gtttatttcc gatttcttct gtgtcgggct gatctgccaa taataaagtg acagcctgcc
     7021 ctaagcgctg atccggaact gaagtaatga caaaggacac aggaataaac gggcggagca
     7081 acttctccat ctcctctgct tgaatcttaa ttcctccact gttaatcaca ttgtctttcc
     7141 ggcctagaat cataaaactt ccatcgggat agatacgtgc aatgtcattg gtctgcaatg
     7201 tttcgtcaca taccaaaggg gcatcaatga ttaatgtatt ctctgcggat aaagacaatt
     7261 ttactgaagg aaatggataa taatgttctg aagccgatgc tccgttcaga cgacgaaggg
     7321 caatatgcga caaagtttca gtcatgccat aagtggagta aacggcagtc ggaagatggt
     7381 ttatctccgt ttccagagcc tcatcaacag ctccgcctcc tataatcaga atatccgttt
     7441 gttttatcgc tctttttctt cgggaacctg catcgtgtta taaacttgca atgggaccat
     7501 tgccacaaat ctcaaaggtt cttttatatc cgccaacgga tgaccggaag caggacgaac
     7561 aatcaggttc aaacctgcaa ccaatgaacg tacgaccacc atcattgcac cgatataacg
     7621 aagattcata cataataatg ccgactcacc tttcttcaaa ttcagaaatt cacaagtcag
     7681 acgcgcactt tgcatcattt gatccttgcg taccatcagt tctttaggta tacccgtgga
     7741 acccgatgta tgaaccgtga tgacaggaga gccattaaac cattcgttca ggaaaagata
     7801 taaatcccaa taagcagaag aatgagcttc tgctcctcct gctatcaatt ggcttatatc
     7861 ttcaaaagtg tattcttttc cttccagtag caagcgctgt tgttgtcgat cgaatatcat
     7921 ctgaatatcc tttaaatacc actaaatacc atcatttaca aaaccacagg caatcttttc
     7981 tgatttcaag aggcacttct atattgtcag taaagagcat acccgttccc aatccttgtg
     8041 gcaacggatt attgaatgtt gcacaccaat gggcgatagc gttcaaacca atgttggact
     8101 ctaaagcgga agtgatccac cagccgatat gttgcttttc cgcttccata atccattcat
     8161 cccctccgca tattcctccg tggagagatg gtttaatgat gatatattgc ggacggatgg
     8221 ttgccagcag tttctttttt tcttccagcg tgttgcatcc tatcagctct tcatccaatg
     8281 ctatcggcaa cggagattca gaagtgagcc gggccatttc ctcccattgt ccggcacgga
     8341 tcggctgttc gatagaatgt aaatcaaatt ctgacagacg tttcagtttt tccattgcat
     8401 cacccggaga gaaagcaccg tttgcatcta cacgcaactc tatttcttta gaagagaaat
     8461 gggtacgaat atgacgtaac aacgccaatt ctttttcaaa atcgatagca ccaatcttta
     8521 gtttgacaca acggaatccg gcttccatct ttttctcgat ttgggataac atgtgatcaa
     8581 aatctcccat ccagatcagg ccgttgattg gaatccctac ctctccacgt gaaaaagccg
     8641 tatcggataa agcccaactc cctgcaaaga aatgccagat agccgtttcc aaaccaaata
     8701 agatggaagg atattggcat aaaacatcct tatcccacat tccttgttct ttctctactt
     8761 gccgacaaat tctttttaat atatcttcat aatcagggag atcatcacaa cttaaagcgg
     8821 gcaaaggcgc gcactctcca attcccactc tacccggaaa gtcaggagaa gtaaagtgaa
     8881 gataccagac ttttcgggta gtatatattc cccgggaagt tcccgcgggt tgcttgaaat
     8941 gaagcaaccg gggaataata tctatcttac aatccataat gaatatcttt tcaatctgct
     9001 aattactgca caatcagtct ttcattagcc tatcattttt aagggaattt cggatattgt
     9061 ttgaagttcg gtttacgttt ctccaagaac gcattcttgc cttcctgtgc ttcatccgtc
     9121 aggtaataaa gtaatgttgc gtcacctgcc aactcctgaa tacctgcctg accatccagt
     9181 tcggcattca atcccgcttt aatcatgcgc aaagccaacg gactaagcaa catcatttct
     9241 tccgcccact gcacgtattc atcttccagt tgttccaaag gtactacctt attcaccaat
     9301 cccatatcca atgcttcctg tgcattatac ttccggcaaa ggaaccaaat ttcacgtgct
     9361 ttcttctgcc ctaccacgcg tgccagataa gatgcaccga atccggcatc aaagctaccc
     9421 acgcgaggac ctgtctgacc gaaaatggca ttttccgaag caatggataa atcacatact
     9481 acatggagca catgtccgcc accaatggca aagccgttca cggcagcaat cacaggtttc
     9541 ggaatactac gaatttgctt ttgtacatcc aatacgctca aacgaggcac accgtctttc
     9601 ccgatatatc cgccacgtcc tttcacattc tggtcgcctc ccgaacagaa tgccttatca
     9661 ccggctccgg taattacaat cacatcaata tccgcttctt cacggcaaat gcgcaatgca
     9721 tcactcattt cggcagtggt agtcggggta aatgcattcc gataacgttc acggttgatc
     9781 gtgatacggg caattccatt ataataatca aaaagaatat cgtcgtattc tctgatggtt
     9841 gtccactctc tttgtgttgg cataatttat ttttgtttta attgatgata ataattcttc
     9901 aacatacgtg catccttgtt tttgttggta aacacttcca gaagcacagg ttgttccata
     9961 gtttccggct gggtgaaagt tttcattgct tcagtcagct cttcatcatt ttgcgcttgt
    10021 agataaagga agccacgttc ctctgcccag cctttagctg acgttttatg gactgctgca
    10081 ataaatttat gtgaggtgcc cgacatatcc aatcccggta aagtatggaa aatctctcct
    10141 cctccgttat ttaataaaag gatacgcagg ttggaacgga cgttgatatt ccacaacgca
    10201 ttcatatcat agaagaaact tagatctccg atagctatga aattcagttt gtcggaagct
    10261 gccgcataac cgacagcggt agacaacgac ccttcaatac cactcgttcc ccgattgcaa
    10321 caaacttcaa tcgtggaagg gatcgaatat agttgtgcat aacgaactac cgaactgttt
    10381 gccagatgca atgcgcagga ctccggcaaa gctttcaata atgtaccgac agccaacatt
    10441 tccgaataag caaactccgg ttcgggaata atcttacaat aattctccca tacacgggga
    10501 tagtcaggag tccggttatc cagcaggctg gcgatcttct ccagaaactc gaacgggtcc
    10561 atttcgatca ccgtagttaa tgagccgtac aaatcaacca cctcaccgtc cggcgatacg
    10621 tgccaatgtt ctttaggcgg atgctgacgg agaaacttct tcaatcgttt ggaaaccaca
    10681 tgtcctccgt aagtaatcag caattcgggc accatctggt ctatcttctc ttcgggcatg
    10741 gcataaagtg ccgcatcgaa attctttacc ggaataccgg gaactgtctg attgccgata
    10801 tgttccgtca accaggcaaa atgtttatat aataacttga tatatctttt ttcaaacagg
    10861 tagataaggt tcatctggcc gatgataatc atgcgcttct gatatttatt catccggtcg
    10921 accagatcat tataatcacg gtcatagacg ttcaatccct gataacgggt tatcacacgt
    10981 acttccggga gtgcatctac cgtgaattga aacagcggtt cggaaatagg aacattgata
    11041 tgcaccggcc cttttccatg atgattcgtc tccagcaaag cttcattcac caggcgatta
    11101 caataccatt catcttcttc cgtatgaatc tccggaagat tgaccgactt ctttaccagc
    11161 gtttgaaaca cacccggttg cggcactgtc tgtccatcca tctgtccgat ccaggcagcg
    11221 ggacggtctg ctgaaatgac aactaaagga acattctgat aaaatgcttc cgctacagcc
    11281 ggatgaagat ttaataatgc agtaccggaa gtgcagcaca cagcagcggg cttaccacca
    11341 ttcaacgcaa gaccaatagc aaaataaccg gcactccgtt catccgtcac tgcataacag
    11401 gtgaagttcg gatgattaga caaagtatgt acgatgggcg tattacgact acccggacac
    11461 aacacaacct tagtaatccc gtgcgcctcg agcaacgcaa ccaactggag tatgttcttc
    11521 ttgtctgtat acatgatgat aattattagt agtttatgat tttaaaggag gcgttgcaat
    11581 cagccgtttg atggtttgca acttcttttc cgtttccagc cattcgtcat tcaattccga
    11641 agaagccagt agtccaccgc cggcataaag agtcagttgt tcatctttaa tatgcataca
    11701 gcgcagattc acatagatgt cagttcgccc ttccgggtcc agccaaccga taaaaccgga
    11761 ataataacgg cggtcgtaac cttcgttctg caatataaac cgataggctt cttctttcgg
    11821 taaaccgcat acagcaggcg ttggatgcaa cactttcaag agatctccca aacctttgtt
    11881 atctttcaaa gaaaaccgga aatctgtttt caaatgtgac aaagcacctg cataagccgg
    11941 ataaggcccg ttctccgtag aatgaatgcc caacgatagg agttggcgac gaatataaga
    12001 agcgacataa tcctgctctt tccggttctt ttcatcccac acttgcggca gtctgccatc
    12061 ttgtaaaggc tgcgttccgg ctaacgcaac cgtatgccat tcgtcttttt cacctgataa
    12121 aatgatttca ggagtgcttc ccagccagat acccgtctgc ggagtgtagc acaagtatat
    12181 atatgaatga atataacgcc tgcacgctgc acgaaatata gacaaaggag aaaaaccgga
    12241 tactttatca atagtaagat gacgtgaaag tactaattta tcaaaagtat tatcacgcaa
    12301 agcatttata aaggtatgaa agcaggaggc atattcctcc gtagaagaag tcaggaacga
    12361 ttcttgtcct tgcatccgca aagcgacttc ccgttcttct gccgtatcat tgtcaatcgg
    12421 caaaggttgc ccccactgat cgggttgaat caatacgaca ggacacgtct cactcacctg
    12481 aaacggagca attacaaatc ctctctgtcc attcagttct ttcaaatcgt atatcaaacg
    12541 gaccgctcct tccgcctgtg tcaacagacg gggaactttc tccccgggaa tgcggtaaac
    12601 agcaaacggc tgcttccgct gaataaatgc atcaatagtt gtcaaattac ttatttcttc
    12661 gtcggtcatc tctttttcat cacactgttg actacccgta tggaagacac tagtttgttt
    12721 gttgaagtaa acacgtctac attccataca tgggaggaac gtcccttatg tacaactgtt
    12781 cctactgcac gcactgtatc tccttcatgt gcagaagata tgtggtttcc actgacctgc
    12841 attcctacta caatctcgtc cggctggcaa agaatcattg aaccgagtcc ggcaactgtt
    12901 tccgccaatg caagagtagc cccgccatgc aaaatgccaa aaggctgacg ggtacgatgg
    12961 tctaccggca ttgttgcttc cacacggtct tcgtcggcat aggtatattg aattcccaag
    13021 tttcccatca atgcgtggcg tgcctgcgca ttcagttggt caaggggaat ttcggctgca
    13081 cgcacttcgg atatgatagc cttctccact gcaacggcca ctccgtcttc ctcattcgaa
    13141 gcagtcacat aatcggcaca ggctttcacc gagtcttgtg aatgtcccat agctatgccc
    13201 agccccgcca attgaatcat tgttacgtca cacacaccgt cgcccacagc aatcacttcc
    13261 tcacgcttca tacctagcac ctccagcaaa gcacccaaag aattggcttt gtcgatggcg
    13321 cagggaacta cttccagaaa atagggctcc gaacggaata cgtccaacgc cccattcagt
    13381 cgtctcttcc agtgatcttc caaaccaagc aatgcttctt cgtcatcgct caccagcata
    13441 cacttacaag gagcaaaatc aacggcagca gaaaattctt cttctttgat tatttgcagg
    13501 tcattcaacc gggcttcatt ttggatatgt tcattttcag gagaatccgt tatgatcgta
    13561 tcatcatgat aagtgaataa agcaaaaccg tttttacggg ctttcttttc cagatacggc
    13621 aacatttcgg gattaatccg acgttcaaac agaatttctc cgttttgtgc attgataatc
    13681 tgacagccat tataggaaag gataaaacct ccatagtttc caagttcgag catcttggcc
    13741 agcggcatca ggccataagt cggtctgccg gacgccagca caatacgtac tcccatttgc
    13801 tgaaccttca acagggcagc caatgtacgt ttactaattt ctttcgcatc attgaggagt
    13861 gttccgtcta catcaagaac caataattta tacttcatga ttacacgatt ttgatttaga
    13921 ttacaaaggt aggaaattga gtgaacgaca gaaagcgtaa acagataaaa ttactttaat
    13981 ttcactctct caaacgcatt tccagataat cgcgaagaat tcgggcgtga ttatacaccg
    14041 gttcttttga agcataaagt agtgttatca ccggatgtgg tttgataaga gtcagaaaat
    14101 cagccattga tggagaagca tccagctctt tttgatactg cgtgacaaaa tctccccaat
    14161 gtccgggaat atcttcatga aaccatttac gtaatgtagg ggatggtgtt atgtcttttg
    14221 cccaataatc gtatttcaac cattctttct tcattccgcg tggccataat ttatctacca
    14281 acacccggta tccatctgtt tctgaaaaat cttcgtaaac cctctttatc cttacctgta
    14341 tcatttccat taatatttag ttatcaatag ataaaccggg aaaaacgaaa attgtttagt
    14401 agaactattt aattcctcaa tgtgtcctgc gcttttttaa attcataagg agtcattccc
    14461 gtctttttct taaaaaggtt atataatatc ggggcactat taaatccgga ttcatcagcg
    14521 atggcacgta tggtatagtt aggatatttt ttcattagct tgatcgcata attaatgcgc
    14581 agtccgttga tgtacccatt gaaattagtt ccggtgcatt ctcttatcat ccgggcaaag
    14641 cgtgcattat tcagatgtac aatctgcgcc aaatcttctc ttgagagctc tggagaaaga
    14701 tatagctgtt tttgaacgac tgtatgattt aattcctgga atattttctt gttctcttct
    14761 tcttccccac tttctttgtc tgtttcgtcc aaaagttcat cctgttcttc aggagaaatc
    14821 aattccggtt ccaattctga tgaaacctcc tgttcctcgt acacttccaa taactgatta
    14881 ccatcttttt tattggcaaa tttctcgttt atcagtttgg caagcatcct gtttttatac
    14941 tcgattatat ggttgaaacg ccacaaacgc caaagtataa acagggtcag cactacaata
    15001 cacgccaaaa agcagagtga aacattcctt atttttagct gtgaggcttg ctcggcgatg
    15061 tattcttctt tttcggaagc accgtacatc gcgttcaatt ctaatgcagc atttttcctg
    15121 tcggtactgt taatgctatc cgttattgca atgatggttt cacgtatttc tgcggcttct
    15181 ttataacgat tcagccccag atatgcctgg acttccttat taagtatagt taaatattga
    15241 gcgttcaagg tatcccgctg tgttctcaac aattctttaa agtccttaca gttgtctatt
    15301 actgtctcat attgtttgga aagaatcaaa taaggaatcg aatacatctt gccatccgga
    15361 gtatgagatt cttttattgc cagatatttt tgataatatc cttctgcttg cgtatatttc
    15421 ttttctaaat aagaaatata ggccaatttt gcatataaat agctatattg accatcaatg
    15481 tagcctcaat gtagcctcgg gacctccgta cttctctaat ttttaagaat gttttcacgt
    15541 tcat
//
