LOCUS       gnlProkkaGLJKAMAC_59   13439 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GLJKAMAC_59.
ACCESSION   gnlProkkaGLJKAMAC_59
VERSION     gnlProkkaGLJKAMAC_59
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 01:58:10
            Original ID  :: gnl|Prokka|GLJKAMAC_59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1399
            Orig. end    :: 14838
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13439
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13439
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13439
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(376..1335)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 56.4; E-value: 5.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.8e-43,
                     bitscore: 135.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSKCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
     CDS             complement(1340..2353)
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             complement(2367..3089)
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             complement(3089..4534)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="Polysacc_synt (E-value: 9.6e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             complement(4531..5004)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg53_9_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_9"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_9_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg53_9_Aminotran_5.1"
                     /locus_tag="ctg53_9"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_11"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8595..9314)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_12"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9378..10526)
                     /locus_tag="ctg53_13"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10645..11268)
                     /locus_tag="ctg53_14"
                     /transl_table=11
                     /translation="MTNREERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKKRMGDVI
                     RLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIPKNTNTV
                     TINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQI
                     EPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(11307..13229)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 124;
                     E-value: 9.3e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_15"
                     /sec_met_domain="Poly_export (E-value: 2.2e-18, bitscore:
                     56.1, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKENTSDMLED
                     HPTTEDLAREDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMNGT
                     SPNLALMKNDILYIPSIHDLEDRGNITVHGEVAQPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTXXXXSFSLMTKFMSVAVPVI
                     RRNRM"
ORIGIN
        1 ctaaggggaa aatatcaacc caaatcccca tattttgaat agtttgcaaa tcattttcca
       61 cacacaaagt acgagtatct atcatttttg catgagtata ataataatcc tcattctttg
      121 gattacttaa gattttataa taactatgtc tcaaggaagg aactaactcc aataatcgct
      181 cataatctga acgtggcatc attatatcaa tatcatcatc ccaaggaata aatcctttat
      241 gcctaacggc tcccaacaaa gtaccccaag ctaaataata gcgaagatga tattgctgac
      301 aaattttccg aatatacaat aaagcgtcaa gttctacttt ttttatttct tgttcagata
      361 atctatttcg tttattcatc tccatctttt tttatataga tatctaataa tagaaaatac
      421 ccatttaaaa agtgcctcat tccaaacaaa caatctcgct gtaagttttt cggatagtcc
      481 tggatgagaa taaagatgtt ccatttgtct ttttagatca tacttttctc gaatgatttg
      541 atataaatca ttttgcccag acaaaatagc taaaatcatg aatttccaca atgtacgtga
      601 aaattcaaat tcaagccctc taacagaata attcactttt ttatagtagt tgaccgtgcg
      661 ttgtgaagct tctatacttg tcaaactttt aatagaaaag attgccatgg ctgactgatc
      721 atttacacga tagtgataaa gaagattgtt tgtataacaa accttattag aataaactaa
      781 atatttcaat ataaattcac gatcttcacc acgagtacac cctatcacaa attctaattg
      841 tttctctttt ataatattat gtcgaaataa catacaacaa atctgaggat tgaaactttt
      901 atctagaata attctttcta tacaacgttt accactcatt tctatatatc cttgagcatc
      961 atccatacag aaaaccatag aacgagtaaa accacagatt gccaaatcag cctgatgact
     1021 tataagctgt aaaagtgtta tcaaaaaatt aggttctatc aggtcatcac tatcaacaaa
     1081 gcaaatatac tctccttgac acttggatag agccttattt cttgcgacag acactcctgc
     1141 attagactga gaaataattt taaaacgctc atccaatgta gcgtaatgat ttaaaataga
     1201 taatgtatta tcttgacttc catcatctat acaaatcacc tcccaattaa cataggtttg
     1261 attcaatata gacaataaac aatcagacaa atatctttca gaattataac aagggacaat
     1321 tatagatatc aacattttac tatttgaaaa atataaactt atatgggata taatatgagg
     1381 gtacaccttt tatgaatgga acgaataggt acaataagaa ataagaaata catagaaaat
     1441 aagaaagaag cttcacttgc tctcttagtt gtccatccaa tcctttaacc actttaggaa
     1501 tcaacaaaca ataatatata ttaaaataaa acgctattct cccgcctaaa tgagctccta
     1561 aaaaagatac gaaaacaaaa cttaacaata aaacattaaa taaattacac ttgtttttat
     1621 ctatgttttt acttcccaaa acaaaacaaa taataaacaa caaaaagtat attaattgag
     1681 tatatttccc accttcaata tccatcttgc catcaagata agaggtatac acccctaata
     1741 tatttagcat ataaaaaaat aaaggtttgg ctactattga tattatagat aataatacaa
     1801 ctaatctaaa ctttagaaat ggcaaccaat atataataat cgctactcct gcagaaggat
     1861 ggaataaagc tgcaatcaat atacataata tatatttaat tagtgaacgt tttactataa
     1921 aacgataacc ataaaaacaa atagccaaag ccaaagcttg tcgaataata ctgagtgatg
     1981 taaaaaagaa gaaacaaatt aaaatagtta ctgataacgc ataatctttt gaatattttt
     2041 ttaaagtaaa tattagaaga gcaaatgttg gaagcccaaa aagaacaaat aacatctgtg
     2101 gagattcaaa atataaagca atctctgccc aaacaatgct taaaggagaa aataagtata
     2161 aaatctgtgc ctcttcttca ttttcaatta atgtataata cgttaaatag tcatacccca
     2221 ctctataacg acaaattaca acaaaaatta taataatagg aacacaaatt cccgctacag
     2281 tagaatattg tcttttccta ctttgtatat ataacaaaaa tagcacaatt agtaaaaaaa
     2341 atagatagaa catgtattat ctactattat ttacttttat caaacaattc aattctaatc
     2401 tctctaccat aaaagatatc agtatgttgc gcatctgaat ctttccaatg aggatttgga
     2461 atcatatagt ctttaccata atgcatacaa agatgttcct cataattttc aggaacaaaa
     2521 gtattaattc caataaatga atattcaatc aaatcaattc taggaaaatg aattctccgg
     2581 attgcattat cacctttttt agttctcttt atatctgaat atactggaac aaaatcataa
     2641 caatagaccc catcacaatt tttctctctt gaaaaaagga aaagatcaat tgtcacacct
     2701 ttataaagat aagtttcctc ataagcatca ataaaatcaa gggcggttat acaccttatt
     2761 cttttgaaac catatttttt taagacctct cttattatat ctgaataatc ttccttaaaa
     2821 aggcccacat caagatcaaa atcatgactt ataaaactgt gttctctaac agcacctaaa
     2881 agagttccaa attctaacca ataaggaatt cccacttcat tcattgcttg atgaaagtta
     2941 gttagcagct cttgtgaata ctgcaaaaat attctatttc tattcttcaa ttttctattg
     3001 ccataaacaa ataaatatat aggacgcata taggttctat accaatgatt ccgtcgtatt
     3061 ttactaataa tcaaactcag tttatccatt acctttttat ttttaatata accgcccata
     3121 tttcatcaaa caaggatcga gaaaagcaat acaacaacgt tccatatagc aataaagcaa
     3181 taacacttcc tactacaatt tgaacaattt caccctctaa caataaaatc atataccaag
     3241 tacctcctcc cattattaat gctaaaaaaa agcttggtag tatatctctc atctgtctaa
     3301 taagacttaa tttaatcaat gattctgtat aataagtatt caaatacaca gcaatcaatg
     3361 aatacataac acgcccccaa cacataccta caatccccca aggaatagat agaagaagga
     3421 tccccgtcgc taacactttt tttataactt ctaaacgtaa agccaagtct gaacgtccct
     3481 ttacatatag taaattcaaa tttatactac tcaaatgatc aaacatccaa tctaaacaca
     3541 atatttgaag caatacaact actcctatcc atttttctgt caaaagcaat aataccagtg
     3601 gctgagctat gacaattaac aaaatcatca atggaaagat aaaagcagaa gataaacgga
     3661 catatttcct atataaagca gataatctat cattatcatt ttgcacaagg ctcaatatgg
     3721 ggtatgtcac tctagaaatt attgcactca aattatatga aggaaactga gcaaattgtt
     3781 ccgcacgagt ataaaatcct aaatcaaccg acgaaaactt ctttcctata actatagcat
     3841 acagattttt atataaagta ttaagaatat tagctaatac taattttgac ccaaaagcaa
     3901 ataataaacg aaacgatttc aatgaaaata tccacaatgg tttccatcta caaaaatatg
     3961 catacaaaac tacaatcaac aatccgttta ctaaagtttg tccaactaaa gcccaaactc
     4021 caaaatctaa atatgcagcc caaatgccaa taatacctga aaccaaagct gcaataaatg
     4081 agacttttga ttgagtttta aaatctacag ctattattaa tttagtttta ggaataatcg
     4141 caaaggaatt taaaacaata acaatagata aaattctagt aatctcaact aattgaccta
     4201 ttttataaaa ccacgatata taaggagcta gaaaaaaaat tagaaaataa ataactaatg
     4261 atgctaatat attaaaaaag aaaactgttg aataatcaat ttcagtacgt tccttataac
     4321 gaataagggc attagtaaaa ccactatcca ttaacgtttg agataattga agaactattg
     4381 ctaacattcc taccattcca taatcagatg gcaatagaaa acgcgccata atgactgtaa
     4441 ctacaaactg tatcccctgt gataaaaatc gttcaactgc actccaaaag attccacata
     4501 tggctttgtt ctttaaagaa gttttttctt tcatttatta aaacgttttt tcacaatagc
     4561 tggtacacca gctaccaata ctcctgaagg tacatctttt gttacaacag ctccagctgc
     4621 tactacaacg taatcaccaa tagttactcc aggaaggatg gtaacattag ccccaatcca
     4681 aacattatct cctataacta ccggtgcctt tttataagga taaagaactg ctaatgcatt
     4741 atacggtcca ttaggatcag cagttgtcaa tatagtcgtt ccataggcga gtgttgagtt
     4801 ttctccaata atgattttat cacgagcaat cagataacag cctgaacgta tttcagcatt
     4861 tttacctaag tagatattgc tatatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc gcccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcaggg ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcgtaaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacccggaat cagttccaat atttccttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt gtctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatccgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gagattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcgg gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aggcccggtt ttccagtcgt caccatgaat tatatagtca ggtttaatgc gtttgagatt
     8341 ctcaacatag ctccattctt cttgaggaac aactttacat acgcctttaa tattctgaac
     8401 tacctctttt cgttgttcat aggtcagata aggaaggcgt ttatgctccg caatagcttt
     8461 atctgtaaga agaccaatta taacatcacc gtatttagta gcctcattaa taatgcggat
     8521 aagtcctgga tgcataatat ccgcagtcat cccaatataa actgtcttac tcataatttg
     8581 atatattatt ttaattaaca atacggaaca atatatttct ctgcatattc caaatctgat
     8641 atgtcatcga tttcatacca tttcagccct tctactttat gcacataaac aggagattga
     8701 gaacaagata ttcgtagtaa ttcatactca tatcccaaat tgggttgttc atcaacaata
     8761 ctcgcataat cagcacacat tattttgtaa aaggaaccgg atagtttatg gatgccgacc
     8821 aattcgcctt tagcgtttag tttattctta ttgacagaac atgaagaaag gcgaaaatta
     8881 tcatcatgtt ccacataata ctgatcttga aactttgtca ctggagctat tagcattgca
     8941 tctgccgcag gacactccaa taagctcatt attgcttgtt tctcaaaaat caaatctgac
     9001 tctaacaata aaaaatcatc attgcccaga atctcccgcg tattatataa agtatacata
     9061 ctatttgttt cagcataacg aggactaaaa caggtttcaa gcataggata gtctgtcttc
     9121 aattcttcat acacttcttg tttatatcct gtaccgatta caattcgctc aatgccacat
     9181 gataacaaag tatcaataga acgaactatc attggaatac ctcccacttt gacgaaccct
     9241 ttaggtatca attctgtata ttggccaaaa cgggttccca tgcccgcagc cattatcata
     9301 gctgtacgta tcattcgttt aataatatag taagtgaatt taattgatat aagaatgttg
     9361 taaacgacgt tttagcatca tttatcctgt tctatctcct tatttttcag ttcttttctc
     9421 aagctagcca gcagactttt gccaaaaagc acccacacga gagtaccaga tacggacagg
     9481 aacacaaata ataaaatata aattttgagt cccatacctg aaggtttcaa aggtacaacg
     9541 gcaggctcaa ctactgcaaa gactggcttt tcctcctgta ctttggctct ggatacctgc
     9601 aactgattag caacctgact atatatctga taagccaaac tcatgtcgtt ctgtaaacgc
     9661 tcctgctcag cacgtacact ttgaagaacc acattatcat gggcgtctac ataatccgca
     9721 tattttcttt gagcagcata atattcctgc tgacgttctt taaacaaccg ttccaaatac
     9781 gcacagtctt cttttacttt tgaagttcga tacccaataa tatattcctg taatttatga
     9841 acgacagaat ctgctataac cgcagtgatc tgcggatttt gtaaggtgac cgtaatgctc
     9901 gttatggcgg ttttcttatc aatggatgca ctaatcttct ttttaagaaa attaatcttc
     9961 tcatttactt ctttcgtcaa ttcgatagtt ccttgccgcc ctccactggc aggaaccgta
    10021 tcttctccga ataatgattt aactcctcct attactatgc ccggaaaacc tataagataa
    10081 tcccaccaag gagatgactc ttcatcgaga taagacccca aagtcatttt atcatccttt
    10141 ttagaaacgg agacttccat ttctaaaagt tccaataaaa aaggagttga agaaacaata
    10201 tctgctgaaa gagaagcgtt caaggcatct gtgctttccc ctattagagc cccatctcct
    10261 aaaaacgagg cagcaagtcc ggctaaacca ttactcccct tcgcattacc catttcagga
    10321 gaaagggtaa cctttactgt atactgttta gggatactta ccgctacaat tattccaata
    10381 ataaaaccaa ttccaacggc tttgtataat tttttacgaa tagcaataat cttgcgaaag
    10441 atatcgacca aatcaatttc tatctcatca ctttctgtct tgtgtggttc agagagcaag
    10501 tttttatcct gtcgttgttc tgacataaaa gtaaattcta ttatttcttt ataagattag
    10561 caatagaagc aatcatcata cccaaagaac tgaaggaagt agcataannn nnnnnnngtt
    10621 gttctgacat aaaagtaaat tctattattt ctttataaga ttagcaatag aagcaatcat
    10681 catacccaaa gaactgaagg aagtagcata acctaaaata ttagctatgt tccctttctt
    10741 cttagcctta ccaggcacaa taatctcaca ccccggctca atctgtttct taccgctacc
    10801 cttaacctta gtcacctgac cattcatgta aacaatgaac ttcttactct tccttgcatt
    10861 atcagaatag ccaccggcct gattcaggta ataatccaca ttctttccct tcatataaga
    10921 aaccgtattc ggaaccatga cagcaccatt gatagttaca gtattagtat tcttaggtat
    10981 aaagaccaca tcaccttcac gtaggacaag gtcggcacta cccttaggat tagtcaaagc
    11041 cttctccaga tcaatgccta ccgtaaaggt atcctcaaca ccaataccca aagagtcaat
    11101 catggcttca cccaattgcc tgctcatcag gcgaatcaca tcacccatac gtttcttctc
    11161 accggcactt gccacacggg tcaatttcgc accacgaaga taggcaagac tggtaggacc
    11221 acccgcttta ttcaccagat cggaaagacg ttcctcacgg ttggtcatgg cataatttcc
    11281 tccaaacaat atttcaccat caatgactac attctgttgc gcctgataac cgggactgcg
    11341 acggacataa acttcgtcat aaggctgaag gatannnnnn nnnncgtagg accacccgct
    11401 ttattcacca gatccgaaag acgttcctca cggttggtca tggcataatt tcctccgaaa
    11461 aggatttcac catcaatgac tacattctgt tgcgcctgat aacccggact gcgacggaca
    11521 taaacttcgt cataaggctg aaggataaaa ccgggctgac cgtcgatgac aaaaccatcc
    11581 tttaaagaga aggtatacat ctgaccgata gtatcattat ccgcggtact acggggattc
    11641 ttgattcgtc tcgacacatc aatgcggaca gtagaggcgg cttctttcaa gccaccggcc
    11701 tggatgatca gatcctcaag tgtcatgtta tcagcatagg gataggaatc cggttgggcg
    11761 acttcaccgt gaactgtgat attgccacga tcttccagat cgtgaatgct cggaatgtaa
    11821 aggatgtcat tcttcatcag ggcgaggttc ggggaagtgc cgttcatgat agacttgata
    11881 tctatctgaa caacttcact ggtcaaatcc tcacgctggc gataaaggac ggcacgattc
    11941 aggaaagcgt caccggtcag gccctgggct tcatggacaa gttcgcggat cgtattcagt
    12001 ttaccgctga gctggtagat gccgggacga tagacagcgc cacggatttc cagtttgttt
    12061 gtgaagcggt taaggatggc ttcggctgtt acaacgtcac cgttacgcat tgtgtagatg
    12121 ctgtagtcca tatccttgac tgtgttgacc tcatattcct caccattctg acggacaaca
    12181 cgcaatgaac gggtgtaggc atcggcttca aagccgccgg catatttgat taaagtggca
    12241 aggttctcgt ccttcttcat ttcgaaacgc ataggacgtt ttaccttgcc gctgatcttt
    12301 accaagacat cgtaggcggg gacgataacc acgtcacctt cctgaaggcg gatgtcatcc
    12361 tgtgtgttgc ctttcatgat aaattcataa acatcgatgg tggcgatatt ctttccgttg
    12421 cgtaccaact gaacgtttcg gaggctgccg atatcactca caccgcctgc acggtaaagc
    12481 gcgtggaaga cggtagagaa ggaagaaagg gcgtaggtac ccggctgcac gacctctccc
    12541 atcacattga tctggatagt acggatatta cccaaagtca gacggatgtc ggaagtaggg
    12601 tcggtagtat tgttcagacc gttatagatc ttattcaggg cgcccttcag atagtcgttg
    12661 gcagcggaga ctgtcatacc gctaaggttg acaggaccga tcttctgaat attgatggtg
    12721 ccttcaggag agatctgctg gcggatcgtg ttctggctag caccccagat atcgatgatg
    12781 acttcatcac cgggacccag acggtaattg gcaggagtgg caaggttgac actaggctcg
    12841 aacgtcaggt tgcgggtatt gaagatgttg cgcccgaaaa cctggtcctc acgggccaaa
    12901 tcttccgtag tcggatgatc ttccagcatg tcggaagtat tctccttagt ctcttcacga
    12961 aggcgggact cgttgatatc cgtacccgtg gattgggagg tgtttacatt gttctgctgc
    13021 tcatagagct gcttcacacg catagcctgt tccttggtca cacctttacg cgcaagttcg
    13081 gaagcaagct gtttctgttc cttgccttgc cggatgccgt ccttcacata ttccagtacc
    13141 tgtgagtcac tcatggactg ggccataagc gagccacttc ccagcataga acaaaaaagt
    13201 agaatgctaa aaagtcgttg tattttcatt gacaaataaa aaagttagtt ggtttcacac
    13261 agttcctgca taccgtgaca gaccgcagac aactgttgtt taagaagaga agggggaaga
    13321 acatcaagga gggtcagaga acgctgcaag acagaccgtt ttctatcctc gtcttccgga
    13381 ttggcgtaca tcgacacatt atatccctga aggatggcca aacacagggt agcatcctg
//
