LOCUS       gnlProkkaHHPNJACM_8    12865 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHPNJACM_8.
ACCESSION   gnlProkkaHHPNJACM_8
VERSION     gnlProkkaHHPNJACM_8
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 01:57:32
            Original ID  :: gnl|Prokka|HHPNJACM_8
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12865
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12865
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3600:7865]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3601..7865
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12865
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12865
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(3..65)
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLL"
     CDS             complement(73..942)
                     /locus_tag="ctg8_2"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             complement(939..2084)
                     /locus_tag="ctg8_3"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             complement(2088..3581)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_4"
                     /sec_met_domain="Polysacc_synt (E-value: 4.5e-10, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPITVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             complement(3601..4701)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg8_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_5"
                     /sec_met_domain="Aminotran_5 (E-value: 8.5e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        complement(3823..4611)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg8_5_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg8_5_Aminotran_5.1"
                     /locus_tag="ctg8_5"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(4698..5834)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(5846..7147)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_7"
                     /sec_met_domain="CTP_transf_like (E-value: 1.7e-11,
                     bitscore: 37.4, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.1e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAITEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(7167..7865)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_8"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.3e-13, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(7879..9162)
                     /locus_tag="ctg8_9"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(9159..9644)
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             complement(9648..10172)
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             10694..11032
                     /locus_tag="ctg8_12"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDKSE"
     CDS             11173..11520
                     /locus_tag="ctg8_13"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             11570..12373
                     /locus_tag="ctg8_14"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFRPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
ORIGIN
        1 tgcaaaagac gcttacaaac atgcgaacct ataaatccgg cagcaccggt tactaataca
       61 ttcattaaga ttttatctta cattcaattt aaaccaagat tctggtacag aatccttatt
      121 tataaaatta cctggagcaa tcaccagctt atcatcatat ttcgaaagcc atgctcccca
      181 ccagtaaaaa gagctattcg atattatata attacgaaaa tgcatcatta gaaacatatc
      241 atctatagta ccactatcat cctccttttt acttatcaaa cgaacaggat attttcccgc
      301 tagatgtttt tcaacccatt ctaaatcttg tgaaaaacaa aagaaaacag gagaagtaac
      361 ttttgatgcc ataatatcca tagcacattt atagtaatca tcttctaaca ctccaccagg
      421 agctacatca ctttcctgat accgtctaac cccaatcatt atggcattct tatctagcaa
      481 ttttatttct tccaattcca aatacgatgt gtattctaat tttttttgta ttacaaagtc
      541 ctcttttatc tcttgtttat aatcaagaaa atatttttct gactgccaat atccttccag
      601 aaaagcattt gtaatcttag aactaattaa ccttgattca aagtggggag ggcgctcttc
      661 gcaaatataa cgatatgatg gatgaagtat atgacaacct aaattacgac ttagccttct
      721 ataataattc ccatatgaaa aatcaaatgt taatttttta ttttcaggca agtctaatgc
      781 aaaatatgat aataaaagtt tccttttata aacttcatca tttgcaaaat cagtagtcaa
      841 attaaaagcg aatggtacat tgtttcttaa tgccatggcc ttcaccatag cgtaaataaa
      901 catttgattc cccaatcctc ctcgcaaaga tgatacaatc atttcaatct atttattagt
      961 atatataacc tatttataat tctaacataa cagcggatcc accaattagc tcgctttacc
     1021 ccattaaaat aatgcgtttt ccgttgtttc attttctcat acatttttag aatctctatc
     1081 tgtttcatat aataagaaaa cgagggggaa aaactatcta aatatttttt taccacattt
     1141 atatcgatta tttgtccttt tttatttaaa gtttcaaata cattagtcct aatatctatt
     1201 tcatctgaaa ttactcgcca ttgactcaca atttgctctg gagacaccct aaaatcagca
     1261 tggtcctcta tatgaagtat atctctttga ctgtctctaa aaaaggaaaa accttgccta
     1321 aaatctccac taccaatcaa atcaacaata gaggcataaa gatccaaaat agaagcaagc
     1381 ctagaatctt ttactatttt cttattatta atattatgat agaacataaa aagtttagtt
     1441 cttccatcac taagtagttc tagtttattt ttttgcatga caatttcact ctgcaaagca
     1501 tgcccatggt ctgaaaagaa aaacgaatag tcgtatttat ttacgatatc tggagttaga
     1561 aaattattta aagaatataa tatcactttc tgcccttctt taattcccaa tgaggttcct
     1621 ccataatcat caatggcaga atgataatca tcaatggcaa ttaaggacaa tgtattttct
     1681 gacaaatgaa cagtatcagt aaaatcttca atagtagtaa atatactaat attttcattt
     1741 tctttaaact taaacaaccc tgtttcaata tcagatttag tcgcacacaa atttacttta
     1801 tatcctaacc ctactgcaat atcaaaaata gtttctatat taggtttcat aaaatatctt
     1861 ggccatttga cacgactatc gcagccattc aaatagggta ataggccact ttgcaaacaa
     1921 gctatacttc ttggagtatc aggtgcaggt gtataacagt tagttagaat tgtacctcct
     1981 aaattttcaa aaaacaaatc caacgatgtt ttctccatgt tatcattata taatgataaa
     2041 tgatcaacac gtatcatatc tataaaaact agtagtatct tcatctttta tttacaaata
     2101 gacaataaat tacgaaaagt ctttgaacat aaaaacaaca aaacaaaaaa tgttaataca
     2161 ataaaaacaa tttccacaaa gaaaagtagc caactaggat tagagaactt gacacaagaa
     2221 cctattaata atgtaataac cgtaacaaaa gatattttgg ttaactccac aaaaagtttc
     2281 tttctaatat ctattttcga aatattaaga atatcaacca ttttaggaaa gaagaaaatg
     2341 aatagtgcca ataattctac taatattcca gataacaata aaccaattat tccacaaaat
     2401 ttcgttgtaa aaacagtaat aggtaaatac aacaaagatt ggtaaaataa aatcttattg
     2461 cttttcttta tatctcctaa tgcaaaaaga aactgaaaac agaccttgtt tatagaagaa
     2521 aaaaacaata aaataatgat aaaaaaatta attattttcc ctgaaaaatt gttctcacca
     2581 agccataaat atataaattg ttcattcaat agataaaaac caatacatac taagaaaata
     2641 aaggaaatca aaaaatacac aatattcaaa agctttattc taatagactc caacccctta
     2701 gctgctaaca aattaggaat aataggagca acagaatata aaaatcttaa aactaaaact
     2761 ttaccaaatt ccggcacagt ttgagtaaat ctcaaatttg cagcgtcaat aggagaaaca
     2821 aacttagcag tcaagaaaga attcatatta gtcaacaatg tttgtcctgt tttacctaaa
     2881 aaattatata tagaaaaaga aaagatctcc ttaacattat ttaaatcaaa tacaattttt
     2941 attttctttt ttcgaaattt aaatattaca tagccaacac tacatgacaa aaaaacacct
     3001 cctcgaacaa ctgatgcaat tcccaaagct attagaccat atccatggat aataagataa
     3061 atagatatta aagtacctaa actattgcct agaagtacaa ttagcccgat tgacttacta
     3121 ctaagaaaag catataatat agaagaaaag gaataataat taatagttaa aaatgtacca
     3181 acaagcatta agccaaaagc tatttttaat tcatataaat aattagcttg cattgtaaat
     3241 atactaccta ttaaaaggtt aactactact ccgattatca aaacaattaa tgaaaaaaca
     3301 aacgtaagac aaatacctga aacggtatat aatcctattt ttttataatc atgtaatcca
     3361 taacaatatg caactttttg ttgtatcaca tctgaaaacc caggattgat aagagttaaa
     3421 atagacaata tattaccagt agctagccag aaaccatata aatcctttgg aatatatttc
     3481 aaatacaacg gaaccaaaat aatcccaact aaaattgtat acaaaaattc caagagataa
     3541 aatacaaaat tccattttac tacatttttt ttatctttca tatcccaatt gacaatttct
     3601 ctagtatttt aaaacagcct ccctcatcac ctcaaagaac ctctcaatat cctccacatc
     3661 aatctctccc aacgcacaaa gccggaatgt attcgttgtg gaaatcttac ccgggtagat
     3721 cgtaaagcca cgttcatagc agtaatcatg aaccttatca aaatcccaga ggggatcatc
     3781 aggatacaat acagaaacaa caagacccga ctgccattca cgtttgatcg catactgaag
     3841 accaagctct tgcaaacctt tatggatggc ttcaaagacc ctcttgtgac gggcgaattt
     3901 agcctcttca cctactgcaa aatattcatc aagagcctga cgggcagcgt aaacggtttg
     3961 aacaggagga gtaaaatgca tctcacccgt cttctcaaag taatcgtatt gtaaatagag
     4021 gttacaatag taggagcgtt tcggataatc ccttgaagca cgtatcaggg attcatcacc
     4081 tatgataaag gaaagacccg tcatggcctg aaggcctttc tgagccgaag ccatacaaaa
     4141 gtcaacatta tccttcccga tatcaaaagg aatcataccc agggaggaag tggtgtcgac
     4201 aacaaaaacg gcaccgtgcg aatgggctat ttttccgatc tcacggatgg ggttcaagat
     4261 acccgtaccc gtttcatggt gcgtggtata gaccaaagcg atgtccggat tgtcggaaag
     4321 cgtcttttcg attaccgaca ggtcgggaag ttcgtaaacg gaaaacttca aatcgatatg
     4381 gggaagaccg taatattcgc agacttccac cgcacgggtg ctataggcac cgttattgac
     4441 aaccagaact ttcttatccg caggaagaag agagttcagg cagatatcga tattgatcgt
     4501 acccgagccg caaaacagga cggccgtatg tttggagagg tctccatgcg caacgcggac
     4561 caggtcgtca cgtaactgtt tcatcatacc cgcaaactct ttctcacgcg gacagatatc
     4621 gggaacaacc tgcgccagct ttaccgtatc cgtcgtggtg gcgggacccg gattcaaaag
     4681 gatctttctt tcgatattca tgaatgcgta tcttttaaaa atgccataaa atgctcttta
     4741 ttctctaccg gagtagtcgt agggcgaccc agatcatcac gtgaatcgat ccggacctta
     4801 atttcaagaa gaaccgggcc ggacaggccg gacagcttct caagcgcaca cgaaagccct
     4861 tccttgtcgg aggcagtcag tacatgcgca taaccgcaac ctttcgctat cgaggcgata
     4921 tccagacgga aaccgagcgt gggttgaccg ccgacagatt catgggcacc gttgttgaaa
     4981 aggacgtgcc tgtaattctt gggagaaaga tcgccgatat tgctgacagc acccatgtgc
     5041 atgataaagg caccgtcacc gtcaagacag tagacacggc ggtcaggctt ctcaagggca
     5101 atccccaggg caatggaaga actgtgaccc atggaaccca cagttaggaa atcccttgcg
     5161 tgcccctgcc ctttcgattc acggtactcg aaaagctcac gggagagctt gcccgtggtg
     5221 gaaaccacaa tgtcattgtc cccgaggtgg tcgacaacct gcattagcgc ctcctcgcgg
     5281 gacagaggat agtcattcaa ggcttcctga cgcaatttat attttccaaa cgtatcttta
     5341 cggatgacaa tcgcatgggg aatcgaccgg ctcttcgccg agacaaccgc gtcatggatc
     5401 tgcgccaggg cctcgtcttc atccgtatcc agaattataa aaggaatttt catggctttc
     5461 agaagatcaa gggtaacctc gccctgcttc ttatgctggg gttcgtcttt tgtgccgggc
     5521 tcaccgcgcc agccgaccag caaaagaaga ggaaggctgt acactttctc gtccgcaagg
     5581 gacaagaggg gattcaccgt atttcccaga ccggagttct gcatataaac caaaggaacg
     5641 ttgccagaag ccatataata accgcaggca atgcccaccg cggaaccttc attggcggcg
     5701 atgatatgct taccacgcgg agcatgatcc gtgatatagg cgcaaatatt cttcaaaagg
     5761 gaatcgggaa cacccgtaaa gaagtcaaca ccgtgatgaa ggaacgtatc gtatatcttt
     5821 tctacactta ccataaccgt ctgatttatt tagtgcccgg aatcaattcc agaatttcct
     5881 tgataggcat acaaagcgga cggacctcct cggcgcgctc gttttcaagg atggtcctgg
     5941 ccacgttcat catggccggg taagcggcac ggagaaggtg gttggcgtaa atgactacgt
     6001 tggcacccca ttcgtgaagt tcggattcgt gcacatggtc ataagtcgtc ggaacaacga
     6061 caatgggaac atgggcgtat tctttgcgga aagtccggca gaactcacgg atatcctcac
     6121 ccgacttatc cttgctgtgg atcatgatgc cgtccgcacc cgcctgtaca taggcataag
     6181 cacgttcgag ggcgtcactc atgggtttgc cggcaataag gctttcgata cgcgcaatga
     6241 tcataaagtc accggtgacc tgggcattct tccctgctct gatcttatcg cagaacccct
     6301 cgatactatc ctgagtctgg atagcgtcag taccaaaaag ggaattcttc ttcagaccga
     6361 ctttatcttc aatgattact gcagaaatgc catgacgttc cagagtgcgc acagtaaaga
     6421 caaagtgttc gatcttgcca cccgtgtctc catcaaaaat aataggcttg gtggtacatt
     6481 caaggatatt gttcaggtcc tgtaaacggg tggtaaggtc gaccgcttca atatccggtt
     6541 tacccttact cgtggagtcg gtcaggctgc tggaccacat gccgtcaaag acctcgcgct
     6601 tatccccctt ctggacttca agattctcaa taatcagacc gcaaagaccg tcgtgagcct
     6661 ccaggatacg gaccacaggc ttggcctgga tcaggcggcg gagggactta agacgtacgt
     6721 caggggtagt cccgatcgcc ttgatatcct tgtcgagcga ggaggagttg atgccccggg
     6781 tataagggat ctcgattacc ttgcccccct gggcgttcat cacctcaaaa acctgttcgc
     6841 gcacctcgcg caacgggccc gttttccagt cgtcgccgtg gatgatatag tcaggcttga
     6901 gtttttccag attcggaaca tagctccagt cctcctgggg aacaacctca aaaaccccct
     6961 tgatattctc aacaacctcc ttacgctgat cataggtaag gtaagggagg cgtttgtgtt
     7021 cggtgatggc cttgtccgtc agcagaccga cgatgacatc accgtattta gtagcttcat
     7081 gaataatatg gatcagcccc ggatgcatga tatccgcggt cataccgaca taaattttct
     7141 tgttcatata tggaaaagat ttgtttttaa caatagcgga tgatgtgctc ctcggcatac
     7201 gaaaggtcgg cttcatcatc gatttcatac catttaagac cctccaccct gagcacacgg
     7261 acaggggaaa cggaacggga catgcggagc agttcgtatt cgtaacccag tttaggctgg
     7321 gactccagga tggtcgcata atcggcgcac atccggcggt agaaagtatt ggaaagttta
     7381 tggataccga ccagctcgcc ttttgcctca agggcgtcct tgtctaccga acaggaagta
     7441 aggatgtgat tgcggtcata ttccacataa tactgatcct ggaacttggt cagagaagag
     7501 acaagcatca catccgggaa ttcgtcatcc agcagcgaga ggatggcctt gcgttcaaaa
     7561 acaaggtccg attcaagcag caggaaactg tcatcgccta tcacgtcacg cgtattgtac
     7621 agagtgtaca tactgttagt atcggcataa cggggactga aacaggtctc tatctggggg
     7681 aaatccgcct gaagggcttc ataagcctct tttttataac ccgtaccgag gatgatacgt
     7741 tcgataccgc aggaaagaag ggtttcgata gagcggataa tcataggttt tccaccaacc
     7801 tccacaaaac ctttgggcac aagctcggta taatgcccga agcgggtacc aagaccggca
     7861 gccatgatca ttgctgtttt aatcatgaat ttcagaggga attaatataa gtgaattcaa
     7921 ttgttgcttg aaataacagt aaatcgcaaa aatcgacagg acagaaacaa atcctgaaaa
     7981 aagggcagta cgcatcagca tgacagtcca ggaaatgtca gcagaaacga agttcttgac
     8041 cataaacaca cccgtagtgc ccagatagcc gaaagaatcg gccaaataaa taataaaaac
     8101 agccgtacta accaccctaa gggaagcaat cagacgttct atcaggtaag tgaaaggaat
     8161 ataccccata tacagaccaa gaccggaaag aatcatccac caaataggag aaagaaaacc
     8221 gtacacataa agcaatgtgg aaaaaaccat taaggaaccg cctgtgacgg cgatgcaata
     8281 aatgatatta agagccaaac ggttattacg gacaaacaca atcaggaaca tcagtacaag
     8341 gacaaaaacg gcaatgggaa cctctgtctg agtaaagatc attgcaccct caatatggag
     8401 ctccttccaa atatcggcag cgaaagagtc acgaagctca cggaacacgg tcagggcacc
     8461 gtaaaaaaca accagcatgc agattcccca aaagaattgc ctcaaaaact tacgcctgtc
     8521 tttaccatcc atcggagcac gtttggtacg ctgtatgata tcttgctcat tgggagccgg
     8581 aatctgattg agaagccagc tgcaaagcaa cataacaggg tataccaaca aaccggtggt
     8641 aaaaggcatc caatattccg acacatgcaa attatccatc acgaattgtc ccaaggtttt
     8701 caccaaaccg gaagagacta tcaaagcaac gctcagcccg acattcaata tttcactgat
     8761 acgacgccct tcgatatagc taaaaatgac accccagatc atacccaggg gaagaccgct
     8821 cagaaaaata gaacacacct tcaaaggaac cggaagaagt gcaaaaccca acaaagcaac
     8881 ttcggaaaaa gtaagcagcc ctattatata atagatgcgg tgacccgctt tcatcgaagg
     8941 caaaatacga acaccgatga acttggaaag ggcgtagccg ataatctcag aaaggacata
     9001 caggattttg acatcgaatc cccaaagaat ctcaccttca taaatggctg cggtaaatgg
     9061 cttacggtag gcataggcac aagtataaac cagaaaaatc aaaacgctgg catagagagc
     9121 caaaacgtaa aggggagaac gggaaagaaa ggaacgaatc attcgtgtag ttcgctgtac
     9181 ggataaggat tagcttccaa attattcaaa ctttcagcta tttctttttc agcttttaaa
     9241 agttctcgat tgctccaact ttctatgata gtatgcgcct ctttcgccaa ctcctcttca
     9301 aacacctcac cataacaata agtcaacaac tggcatttca ataaagtagc aggaagttgg
     9361 tcaagcacgt cccaacaacg attgagaaca acttgctttt tctcctcctt gtcaccctga
     9421 ttatagatgg ttgcattgta acccatcaat aatgccagac agatgtttgc ttcctcttcg
     9481 ggagtagcac cacgctgagg atacaacgca tcggattgtt ctaaaacttc tttgttcaac
     9541 tgacggaaat gatcggtata aataggagca ccatccacac ctaaatagag taactcgtgc
     9601 gcgagactct gtaattgttc aatttgagaa gtgagtgtat tcataactta aatgacacgt
     9661 aaataacttt taggaacttt gacgctggcg ctcaatacac cggcaatacg aataacaaca
     9721 taagttttgt tggcctcgct ggcaagttcg ccctcgacac cacagaaatc acctttaact
     9781 acctgaaccc tgctaccaac agataaatgg tcattatcga aactgacgcc attcggatct
     9841 aaatccatga caaatatgaa gtcctgcatc tgtttatcag gaactatcag catggccctg
     9901 gtaagcaggt ctttcatata aaaaagctgg atattgtatt tattagaaat atcacaagca
     9961 tcttgcttgg tagcttggat gaagataaga ttcttaataa cagggacttc cacccgtttt
    10021 cgacgatatt tcaactgccg gatgacaaac tgagtgggaa gatagtaatt gagatcaagt
    10081 tcagtcttca atttttcaag agagtcacga atagcaaact cttgtttatc tcgggtacgg
    10141 gcggcaaacc aatacttctg ttgttcagac atttacgatt tatacttggg gaaattttcc
    10201 tttgtttcgg gtgcgcttcg cggtttgaac gagacatctt ttctctttca aaccgtcaaa
    10261 ttttacgaaa catttttaga agttgagaac gaacgaatgt gtttcaaaaa acgttcgttt
    10321 gattgaacaa aggtaaggag tctgttttaa tgtacaaaat atttagtgga taaaatttta
    10381 tcaaagattt tatattgttg attttcaaac acatatagag caaaaaaagt tctctgctca
    10441 gctactttac aatattcatt ttttcatcga aaaaaactca aaaaatgctg tttcaaaaga
    10501 cgaacgtttt ttgaaacaac gcctatatct taagataaat aactaataac aagatcctta
    10561 cacttcaaga ttctcccttt aaactaaaaa aactccggta ttcttttata tttatatttt
    10621 tttatacaaa ctttgtcctt tcataaattc atttaataac taacattatg gaagaaaaaa
    10681 agtagttatc tcattgaatg ataacttagt aaccatcgaa gtaaatggaa aagtaatctt
    10741 tgcgggtaaa gccgacttgc aattcagcct caatcaaaag gttagagaac cactacgcat
    10801 cacaaaaggc aaaggaaagc taatggaggc acttaccgaa agctttatca aaggcggaat
    10861 caacagcatg gaaaacagac ccattgaaga actacaggaa acaataaaag aatatctcac
    10921 ctttgaatat cagcgcaaag gcattgctac agagcctaat aaacgttctt ttctatcaga
    10981 gctgaaaaaa tatgccagag cattccggaa aaagcgagat aaaagcgaat aaccgattgt
    11041 taaaatcctg taaaagtccc tttctaaagt acttttacag gattagtcta ttcaaaactt
    11101 attaccgtac tttgccacgg gtaaaaataa aagcccgaca ataactcatt aataaactta
    11161 aaaaaatcaa ttatgaaaaa gaacaggaaa gcagtatcga aaaacgaaat gatgaaagga
    11221 aaatggaaaa gacaaatcat gctcgaaaag gactacacag aacagtgctc cgaatggatg
    11281 gcagaacgac tggaagccct catagaatat atgcaatatg gacatgcagc cgtagcttat
    11341 atgaaacagg acggaacatt caaactggtg aaaggaacat tggtgggata cgaaaaagat
    11401 ttcggaaagc agtatgatcc gatggaaata aaaaacacag tggtctaccg ggatgtggag
    11461 caacaaaggt ggatgacctt caaaatagag aatttcatgg aatggagagc gatcgtatag
    11521 gagaatcttt cagtgaccaa ttaatcagta acataacaac ttaacaatta tggcaacaac
    11581 atacgatgga ataaattact ttccgatagc tgtgaatttt atggaagaga acgcaatgga
    11641 ggtaatagaa gcaaaatatg gcatgaaagg actcgcgatt gtactgaaac tcctatgcaa
    11701 aatatataaa gaaggatatt atattccgtg gggtgaggaa caatgcctta ttttcgccaa
    11761 caagacggga aaagaggcag acgcagaaga ggtgcagggg attatcgaga taatgatcga
    11821 gaaaggaatg atagacaggg gaagctatgc ggaacataaa gtactgacct ctgaagcaat
    11881 acaaaaagta tggatagagg caaccaagcg aagaaagagg aactggacag ccatgcctta
    11941 tctactgata aaaccgaaag agacatgtaa tgaagaaaag accgtctgca cgcaaaatgt
    12001 agagcaggat gcaggctctg atgcaaaaaa tgcatgcaat accgaacaaa gtaaagtaaa
    12061 gcaaagtaga gaatttcgcc cctcagctcc cccaaggggg aaggaagagg aagtcaatgc
    12121 tacgccggtc agtatgcccg gatacgcatt taatacaatg acacacaact acgtgggatt
    12181 aatgggaaac ctggaacgat tcggaataac agacgaaaaa gagatcgaag caatcctgcg
    12241 actgtcggat tacgggagaa aaggaacccc tgtatggaaa ctgatttgca gcacgaactg
    12301 gagtaacatc ggagcaaaag gaaaatacat gatcgcagcg ttgaaccggg caaagaaaag
    12361 aagcggaacc taaaaaagaa cttttctgac aaacagtaca ttttatattc tggaaaatgc
    12421 tatttgcttg caatcaatta aagaacgcag ctgttttcct ccggaaacga gcactgattc
    12481 tcaagggatt gaaaagcgat tcaaaaagca ctaatacgaa gttaaaatcg tgacttcagg
    12541 aagttaactt cccgaagata cgattttaac ttcgtaaaat tatgatatta acttcgtaaa
    12601 caacaagatg ttaacttcgt aaacggcatc atccggacat caaagcaatc aaaaaagatt
    12661 gtcagactat agtatttcag gcagttgcca gacttgtatg tgacgaatcc cttctttgga
    12721 gggcaatgtg gtatcgtcca tagaaacgac ccacttttca taattgtctt gtatcatctc
    12781 cagcgtgttg tacatttgct ccacttgaaa atcatcattg agcagaggtg cacattgcaa
    12841 atacacaatg cggtctttct tcctg
//
