LOCUS       gnlProkkaGPGAIPCF_122  10463 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPGAIPCF_122.
ACCESSION   gnlProkkaGPGAIPCF_122
VERSION     gnlProkkaGPGAIPCF_122
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 02:01:06
            Original ID  :: gnl|Prokka|GPGAIPCF_122
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10463
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10463
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7094:8585]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7095..8585
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..10463
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10463
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             294..854
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 71.2;
                     E-value: 1.4e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg115_1"
                     /transl_table=11
                     /translation="MDEIILMRKLKKKDERALGKIIDLYSAYITCIVWELLHKKGTKED
                     IEEVVADTFISLWLTAERINYKQYSSIKSYLAMIARNKAKDWLRSYRGGILELNDDILL
                     IDGDVERLILQKEQQLIIGRTLEKLKEKDKAIFIMYYYRYKKIEEIAEILKMNPQTVKT
                     RLRRGREILKRILLEEGYDASEI"
     CDS             838..1578
                     /locus_tag="ctg115_2"
                     /transl_table=11
                     /translation="MPVKFKISEMFDNSCELFENEMQHKNIESEKRIKEIVFLEIGHTK
                     AKRNRRRYIAVLVAAMGIGGITVGAHEVLKSAGEIKNNEEVVLENQNGLALYEKENSGA
                     IQMEVETDMILPENLYKDGIPIAKYIMEFKTERNGSVPECYLDNGTMIVLTDFDGDTWN
                     MKTGDTFILDFIQSDSDERGKARTLEIGYIFNGEVIDEKVISETENKIILDIPKSGQYG
                     VYLKNVSSDRVTISQGILTVERGK"
     CDS             1582..2025
                     /locus_tag="ctg115_3"
                     /transl_table=11
                     /translation="MKKTRIFLGILGLICLVAMPVSAADNVRNITTYSICREDLYKDQI
                     EDRMGLQQISIESGKTVSFYDSNGSMFYVSGGTTVTFRVNLNVSSSVKMGYINQNGSRT
                     QKYSGSGTSHKTSFTIPSSGYYRFYVTNSGSKTVKVTGGEISF"
     CDS             2030..2998
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 49.4;
                     E-value: 8.3e-15)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg115_4"
                     /sec_met_domain="PF00561 (E-value: 1.4e-15, bitscore: 47.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.6e-10, bitscore:
                     29.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRKIFKIIKWLVIVILILCCMGITWNYFCKRREIPKIQAAYGKA
                     VKVNGKKMTVEIAGLQAEESPVIVLLPGLGSPSPVLEFRPLAEKLGKTYKVITVEPFGY
                     GLSDPADTERSIENIVEELHACLEEIGVHRYYLMAHSISGLYSLYYANTYPEEVRGFIG
                     IDSSVPKQNENEPFDTTKLNLLMAYLSKTKNVLGISRIFSIGNPEKAIYADQNYSYSQE
                     DLEVFRILSLDNSYNKTVMNELKQVEKNLEIVQDMKFPEEVPVLNFVSEDNCEIFPEWE
                     KLHRSVLSDNQENRLVMLKGGHYLHFEQKERINYYVVKFIN"
     CDS             complement(3140..3283)
                     /locus_tag="ctg115_5"
                     /transl_table=11
                     /translation="MCNNSKNTTKESSNNTNEENTSSSKFENNLDDEIDSETLIPIMQL
                     LL"
     CDS             complement(3298..3924)
                     /locus_tag="ctg115_6"
                     /transl_table=11
                     /translation="MNKLIKLDYRLISSQIIIILCAILFSVYLGVFKAMPTFSIGILFM
                     MTFIFSTVPFNVSSYYKSCFYNMLPVSTKKKVLARYCYLFINIFLSTLLSFIIFYYAGR
                     KYSIDDSMGYYKIIFIIAITCLSLCSVQYVIYYKIENIRNQQFAVWFRLIPAFALMFFV
                     NIFSERASHFLYFNYFHLLILTGISIFILSICIALSFYINAHKKN"
     CDS             complement(3917..4774)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 149.6; E-value:
                     2e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg115_7"
                     /transl_table=11
                     /translation="MCILKLNNVSKTFNNFYLDNINFELPKGYIIGYIGPNGSGKTTTI
                     KLITDQYLPDSGTIYINGKKLSDSEKDYRNSIGYIADDFYFPDFFKIHTIKKILKDFYP
                     TFDPLSFDEYISLWKLPCNQNVGTFSKGMKVRLMFACVLSRKPEILILDEATNGLDPVV
                     RTEILQILKDYIKDGEHSVLFSTHILSELDNIADYIYMILDGKCTLMGTNDELLDNFIL
                     ITGSIQHQDFFKKKCVSFIQKDNYLEGLVRSDNIDFLPNNLSFKRPTLEQILLYHSKED
                     TYCE"
     CDS             complement(4776..5177)
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 58.4; E-value: 1.3e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg115_8"
                     /transl_table=11
                     /translation="MDFTILISNSSELPIYMQIVEQIREQIVLEKIPSNTPLPSIRQLS
                     KDLDISVITVTNAYNKLQIEGFITSLPGKGFITCSRENKEIQYYYKNNIYQYLRLAIRN
                     AQYIDIEYNELIEDFSKIYNNELQTKKEE"
     CDS             5459..7123
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 204.2; E-value:
                     5.9e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg115_9"
                     /transl_table=11
                     /translation="MSALKFVGKHMKRHKGKIIISLVLSIVISLVSSLGPYIMKLIVDV
                     GIPEGRIEYILILSSMAVAVYFLYSMGNFLLSYIFTLLSETVNLDIKKEIYNKLMYYPL
                     SFFGNKEKGYILARTNEINSIKPLFSSTTCKLGLSIIEFVIASVFLFSINTSFTICIYL
                     FLPIYFLLIKMMMNKTRYIVGKNMEEVATANGTIQQVLSGIEQVKISNKEKTESQKINN
                     LNERISKLSTKQSVLLNLTSESIMLICNIISVLVLVISAIHISKNNMTMGDYFAFSGYL
                     PKLLAPVQALASSLISIQPAIASLKRLVQYFSEKIEVENDLPYLNISNGQIVFENMSFK
                     YEEDSKMIINKLSVKIPGKSKVLIKGRNGSGKTTLLKLIMGLYTNYTGYIYIDNKDIKN
                     YRKASIRNQISIVSQNIFLFSGTVKENILYSVDNFTDYELVEALKDSGLAEAFRKGQLN
                     LESNVGENGMLLSGGQRQMIAIARAIMKKSKILIFDEATSNLDSKKTDDLYKMIHEKFK
                     ESTCIIVSHDYIDGIRFDKIINLDKENKNEKTNDTDI"
     CDS             7095..8585
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg115_10"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.4e-09, bitscore: 27.7, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2e-17, bitscore: 53.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-12, bitscore: 36.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRMTLTFKSKKGNEYLYDDSTGLILPWSKEDEKILKQLLEGNK
                     TEDILKDGDVHESKVHYLSYLLDQTGAFLEECDIRVKYPGEEEIVDFIGSNLARQLILS
                     VTDDCNLRCKYCIYSDAYHLTKDKSCKYMTEETAKRAIDYFFELISPQLRRNPRKKIGI
                     TFYGGEPLMNMKTIKYAVRYINQFYKENVYYMLTTNGLLLNDANIKFLAENEIGLAISI
                     DGPQKEHDRLRVKIDGSGSFEQIANNIKKLSEAYPYYFRTRVNAVCVFDPKTDIEKVEE
                     FYEELEKTYNIPRAIFVNKVSDNETNYYDQFSDTDNQKYDDRIKNLMRKFHEKKVADKE
                     ISSYLSAIAGGGPMSVIVRRRIDEIQGHCIKSSGACIPGQKICVNSSGIFDICERVNGH
                     NSIGNVEQGIDGKAVLKIMKEYNEVALEDCSNCPIKKLCGYCYLNFETENGFKKNKAGC
                     AFHRNVVKTNLSRYVSIYEENPNCRYFLDTDTAELENN"
     CDS             9051..10373
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg115_11"
                     /sec_met_domain="PF04055 (E-value: 2.9e-13, bitscore: 40.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFFRLNAFAFLVAGEKDYSIYDMKNNFIYMLNREAGMLIKRLENN
                     VDLDTLKEYEKHKNVCMDFLGMLAQKGLGDFFENEVHIEKFRFNAPIQKKGMLEPVPQY
                     VKCYLEISNECNLKCSFCGKSKYINWLGCQSCFRNQNHQEASIKYDKLVSELEEIGVKE
                     LILGGREPFCKSEVIYKLIEQCKKNSRINLIITTPGSVEANEILKVSSLYEKIKLNIVV
                     FATRRFSEFLSEEMQEFIRKQEKLFSVLHKNNIPYSVTLQIYDKNRNYAEAIIRDIKTE
                     LGITPMIADIVDMEKREKLTHIGMNQKMLSQYRNPREFYLRKSYNPCLYGVFSIDLFGN
                     VNPCPGIHKALGNITDNTLHEILSKDDLYSYWTYSKDKVVYCKNCSMRYFCSDCSVFEL
                     ASHESSNVHNMFCPANIEEKASDISNVEFVGWNKEYLSLDY"
ORIGIN
        1 tggtcaatgt ggggtataga ctgaagaagt tataagtata tatatatcat gcatacaatt
       61 ttgactttcc tataaatgta ataaagtaga tgataattat agaattataa aaagtttagg
      121 agctttaaat ctgtagttca gatttaagct cctatttccg ttttgaaatt tttatacaag
      181 taggatatag ataaaagaat ttcaaaatta aatattaaag ttaaagggac tttttgaaac
      241 caaattccat ttttatacgt attgataaaa aacaggcaga tgggatttgg acaatggatg
      301 aaattatttt aatgagaaaa ctaaagaaga aagatgagag ggcattaggg aaaatcattg
      361 atttatatag tgcttatatt acatgtattg tctgggaatt gctgcacaaa aagggaacta
      421 aggaagatat agaggaggtg gttgctgata cctttatttc cctatggcta acagcagagc
      481 gcattaatta taaacagtat agcagtatta aatcttattt ggctatgatt gcaagaaaca
      541 aggcaaaaga ttggttacgt tcatatcgtg ggggaatttt ggagcttaat gatgatattc
      601 ttttgatcga tggtgatgta gaaagattga ttttacaaaa ggagcagcag ttgattattg
      661 gaagaacatt ggaaaagctg aaagagaaag ataaagcaat ttttattatg tactattatc
      721 ggtataaaaa aatagaagag attgcagaaa tattaaaaat gaatcctcaa acagtaaaga
      781 cccgtctgcg gagaggaaga gaaattctga aaaggattct tctggaggag ggatatgatg
      841 ccagtgaaat ttaaaataag tgaaatgttt gataattcct gtgaactatt tgaaaatgaa
      901 atgcaacata aaaatattga aagtgagaag cgaataaaag aaattgtttt tcttgagata
      961 ggtcacacca aagccaaaag aaatcgcagg agatatatag ctgttttggt agcggcaatg
     1021 ggaattggag gaatcactgt tggggcacat gaagttttaa aatctgcagg tgaaatcaaa
     1081 aataatgagg aagtggtttt agaaaatcag aatggacttg ctttatatga aaaggaaaac
     1141 agcggagcta tacaaatgga agtggaaacg gacatgattt taccagaaaa tttatataaa
     1201 gatggaattc ctattgcaaa atatattatg gaattcaaaa cagagcgtaa tggatcagtg
     1261 ccagagtgtt atttggataa cggaaccatg attgttctta cagattttga tggagatact
     1321 tggaatatga aaacagggga tacttttata ttagatttca tacagtctga tagtgatgag
     1381 agaggtaaag caagaacatt ggagattgga tatattttta atggagaggt gatagatgag
     1441 aaggttatat cagaaacaga aaataagata atcctggata ttcctaaatc aggacaatat
     1501 ggtgtatatt taaaaaatgt atctagtgac agagtaacga tttcgcaagg aatattgact
     1561 gtagaaaggg gaaagtgaaa gatgaaaaaa acaagaatat ttttgggaat attagggctt
     1621 atttgcctgg ttgctatgcc agtttcagca gccgataatg taagaaatat aacaacttat
     1681 agtatttgta gagaagattt atataaagat cagatagagg atagaatggg actacagcaa
     1741 attagtattg aaagtgggaa aacggtatcc ttttatgact ccaatggctc tatgttttat
     1801 gtgagtggag gtactactgt tacttttcgg gtaaacttga atgtatcttc ctctgtaaag
     1861 atggggtata tcaatcagaa tggaagtaga acccaaaagt atagcggttc aggaacttcc
     1921 cataaaacat catttacaat accgtctagt ggatattata gattctatgt aaccaatagt
     1981 ggatctaaaa cagtgaaagt aacgggaggt gaaattagtt tctaaaatta tgagaaggaa
     2041 aatatttaaa ataataaagt ggttggttat tgtaattctg attctatgct gcatggggat
     2101 cacatggaac tatttttgta aaaggagaga aataccaaag atacaagctg cttatggcaa
     2161 ggcagttaaa gtcaatggga aaaagatgac tgtggaaatt gctggtttgc aagcagaaga
     2221 atcccccgtt attgtgttac tcccaggact gggatctcct tctccggtat tagagtttag
     2281 accgttagct gagaaattag gaaagacata taaagtgatt acagtggagc cttttggcta
     2341 tggactgtct gatcccgcag atacagagag aagcatagag aatatcgtag aggaattaca
     2401 tgcctgttta gaggagattg gagttcaccg atattatctg atggctcatt ctattagcgg
     2461 attgtattcc ctgtattatg ctaatactta tccagaggaa gttcgtggtt ttatagggat
     2521 agattcttct gtaccaaagc aaaatgagaa tgaacccttt gatacaacaa aattaaatct
     2581 tctgatggcc tatttaagta aaacaaaaaa tgtgttggga attagccgga tattttcaat
     2641 tggaaatccg gaaaaggcta tctatgcaga ccagaattat tcttattcac aggaagactt
     2701 agaagttttt cggatacttt cccttgataa ctcttataat aagactgtaa tgaatgaatt
     2761 aaagcaggta gaaaagaatc tggagatagt acaagatatg aaatttccag aagaagttcc
     2821 agtgctaaat tttgtttcag aagataattg tgaaattttt ccagaatggg agaaactgca
     2881 tagaagtgtg ttgagcgata atcaggaaaa tagattggta atgttaaagg ggggacatta
     2941 tctgcatttt gagcagaagg aaagaataaa ttattatgta gttaaattta taaactagac
     3001 agaaaatgtc ggtacaggtg atagtaaaac ctgtaccggc atttttattt acagaaaggt
     3061 tactattgag taggtacgga ctatctacta tttacgtatg agaaacagaa tagtctattt
     3121 aaggtttagc acagctaatt tataaaagaa gctgcatgat aggaattaag gtttctgaat
     3181 caatttcatc gtcaagatta ttttcaaact tactactaga ggtattttcc tcgttggtat
     3241 tatttgagga ttctttagta gtgttttttg aattattaca cataggtttt tcctccgtta
     3301 attttttttg tgtgcattaa tataaaaaga cagagctata catattgata aaataaaaat
     3361 tgaaatacca gttaatatta aaagatgaaa gtaattaaaa tataaaaagt gagaagccct
     3421 ttcactaaaa atattcacaa aaaacataag cgcaaaagca ggtataagcc taaaccaaac
     3481 agcaaattgt tgattacgaa tgttttctat tttatagtat atgacatact gaacactaca
     3541 taatgaaaga catgtaatgg caataataaa tattatttta taatagccca ttgaatcatc
     3601 tatagaatat tttcggcccg cataataaaa aataatgaaa cttagtaatg tcgaaaggaa
     3661 tatatttata aaaagataac agtagcgtgc taacaccttt ttctttgtag aaacaggaag
     3721 catattataa aaacaggatt tataatatga ggaaacgtta aaaggaactg ttgaaaaaat
     3781 aaaagtcatc ataaaaagta ttcctattga aaaagttggc attgctttaa aaactcctaa
     3841 atacactgag aaaagtattg cacataatat tataataatt tgtgatgaaa taagtcgata
     3901 gtccaatttg attaatttat tcacaatatg tatcctcctt tgagtgatat aataatattt
     3961 gttcaagtgt aggtctttta aaagacaggt tatttggaag aaaatctata ttatcagagc
     4021 gaactagtcc ttccaaataa ttgtcttttt gtatgaaact aacacatttt tttttgaaaa
     4081 aatcttggtg ttgaattgaa ccggtgataa gaatgaaatt atcaagtagt tcatcatttg
     4141 tccccattaa tgtgcatttc ccatctaaaa tcatatatat ataatcagct atgttatcta
     4201 attctgataa aatatgggtg gaaaataaga cactgtgttc gccatctttt atatagtcct
     4261 ttaatatttg taaaatttct gttctaacaa caggatctaa accatttgtg gcttcatcta
     4321 aaataagaat ttctggtttt ctgcttaaaa cgcaagcaaa catcaggcgg actttcatac
     4381 ctttagagaa ggtgcctacg ttctggttac atggtaattt ccacaaacta atatactcat
     4441 caaacgataa tgggtcaaaa gtcggataga agtctttaag tattttcttt attgtatgga
     4501 ttttaaagaa atctggaaaa taaaaatcat cagcaatata accgattgag tttctataat
     4561 ccttttctga atcagaaagc ttttttccat taatatatat agtgccagaa tccggtaaat
     4621 attgatcggt gattagtttt atggtagttg tttttccaga accattagga cctatatatc
     4681 ctataatgta acctttaggc aattcgaagt ttatattatc taaatagaag ttattaaatg
     4741 tttttgatac attatttagt tttaaaatac acatattatt cctccttttt tgtttgtaat
     4801 tcgttattgt atattttaga aaagtcctct attagttcat tatattctat atcaatatat
     4861 tgtgcattgc gaatagccaa tctgagatat tggtaaatat tatttttgta ataatactgt
     4921 atttctttat tttccctgct acatgttatg aacccttttc caggtaaaga agtaatgaag
     4981 ccttctattt gtaacttatt ataagcatta gttactgtaa taacgctaat gtctaaatct
     5041 tttgataatt ggcgaataga aggaagagga gtattggaag ggattttctc taaaacaatt
     5101 tgctcacgaa tctgttccac aatttgcatg taaattggaa gttcggaaga attgcttatt
     5161 agtatggtaa agtccatttt gtgttcacct cctttgcgaa atatctgtat atatataatt
     5221 atatacggtt aataaaaatg tgtcaagata taaataaata tatagaatga tgaaatattg
     5281 tattatcttt aaaattgtat tgcatgtttg attaaaattg ggaatgaagt aagataaaac
     5341 tttgtcattc aatcacaaaa atggtatatc atgcattttg tcttgtatta aaatccattt
     5401 tttgtaaaat atgtttaaca aacaaataaa ttgtttagac gaaaggagag atatgatcat
     5461 gagtgcttta aaatttgtag ggaagcacat gaaaaggcat aaagggaaaa taataattag
     5521 ccttgtgcta tcaatagtca tatcattggt ttctagtttg ggaccctata tcatgaaatt
     5581 gattgttgac gttggtattc cagaggggag aatagagtat attctgatat tatcaagtat
     5641 ggctgttgct gtatattttt tatactctat gggaaatttt ttactatcat atatttttac
     5701 attactgagt gaaacagtga atcttgatat taaaaaagaa atttataata aattgatgta
     5761 ttatccgctt tcattttttg gaaataagga aaagggatat atattggcaa gaactaatga
     5821 gatcaattcg ataaaaccac ttttttcaag tactacatgt aaactgggtt taagtattat
     5881 agaattcgtg attgcatcgg tctttttatt ttctataaat actagtttta ctatatgcat
     5941 ttatctgttt ttgccgattt attttcttct aataaaaatg atgatgaata aaaccagata
     6001 tatagtcgga aagaatatgg aggaagtagc cactgcaaat ggaacaatac agcaagttct
     6061 ttcaggaatt gaacaggtaa aaatttccaa taaagaaaaa acagagtcgc agaaaataaa
     6121 taatttgaat gagcgaataa gtaaattatc aacaaaacag agcgtattgc ttaatcttac
     6181 atcggaatca ataatgttga tttgcaatat tatttctgtc cttgtactag ttatatcagc
     6241 tattcacatt tcaaaaaaca atatgacaat gggagattat tttgcttttt caggatattt
     6301 gccaaaacta ttagcacctg ttcaagcgtt ggcttcatca ctaatcagta ttcagccagc
     6361 tatagcttct ttgaaaagac tagtacagta tttctcagaa aagatagagg tagagaacga
     6421 tcttccatat ctgaatataa gtaatggaca aatagtcttt gaaaatatgt cctttaaata
     6481 cgaagaagac agtaaaatga taataaataa gttgtctgta aagattcctg ggaaaagtaa
     6541 agtacttatt aaagggagaa atggaagcgg aaaaactacg ttacttaaat taatcatggg
     6601 attatataca aattatacag gatacatata tattgacaat aaagatataa agaattacag
     6661 aaaagccagt attcgtaatc aaattagtat agtatctcaa aatatttttt tattttcagg
     6721 aacagttaaa gaaaatattt tatatagtgt ggataacttt actgattatg agttagttga
     6781 ggcattaaag gatagtggct tggctgaagc ctttagaaaa ggtcaattaa atcttgaaag
     6841 taatgtaggg gaaaatggga tgttactatc aggaggacaa agacaaatga tagcaattgc
     6901 tagggcgata atgaagaaat ctaaaatatt gatatttgat gaagctacat caaatttaga
     6961 ttcaaaaaag actgatgatt tatataaaat gattcatgaa aaatttaaag aaagtacatg
     7021 tattatagtt tcgcatgatt atatagatgg aattcgattt gataaaataa ttaacttaga
     7081 taaggagaat aaaaatgaaa aaacgaatga cactgacatt taaatcaaaa aaaggaaacg
     7141 aatatttata tgatgattcc acaggcctta ttttaccatg gagtaaggaa gatgaaaaaa
     7201 ttttgaaaca attgctagaa ggtaataaga cagaagatat actaaaagat ggtgatgtac
     7261 acgaaagtaa agtgcattat ttatcctact tgttggatca aactggagcc tttttggaag
     7321 agtgtgatat tcgcgtgaaa tatccaggag aagaggaaat tgttgacttt atcggtagta
     7381 atttagcaag acaattgatt ttatcagtaa cagatgattg taatttaaga tgtaaatatt
     7441 gcatttattc agacgcatat catttgacaa aagataaaag ttgtaagtat atgacagagg
     7501 aaactgctaa acgtgctatt gattactttt ttgagctgat ttcacctcaa ttaagacgta
     7561 atccaagaaa gaaaatagga atcacttttt atggtggtga acctcttatg aatatgaaaa
     7621 caattaagta cgctgtgaga tatattaacc aattttataa agaaaatgtt tattatatgc
     7681 ttacaacaaa tggattgtta ctgaatgatg cgaatataaa attcctagca gaaaacgaaa
     7741 ttggtttagc tataagtatt gatggtccac aaaaagaaca tgatcggtta agagttaaaa
     7801 ttgatggaag tggaagcttt gaacaaattg caaataatat taaaaagctg agtgaagcat
     7861 atccttatta ttttcgtaca agggtaaatg cggtttgcgt ttttgatcct aaaacagata
     7921 ttgaaaaagt tgaagaattt tacgaagagt tggaaaaaac atataacatt cctagagcca
     7981 tatttgtgaa taaagtttcc gataatgaaa caaattatta tgatcaattt tcagataccg
     8041 ataatcaaaa atatgatgat agaataaaaa atttaatgcg taaatttcat gaaaagaaag
     8101 tagcagataa agaaataagt tcgtatttgt cagctatagc aggtggggga ccaatgtctg
     8161 taatagttag gcggagaatt gatgaaattc aaggacattg tattaagagc agtggagcat
     8221 gtattccggg acagaaaata tgtgttaatt catcaggaat atttgatata tgtgaaagag
     8281 ttaatggaca taattctata ggaaatgttg aacaagggat tgacggaaaa gcagttttaa
     8341 aaattatgaa agaatataat gaggttgctt tagaagactg ttctaattgt ccgattaaaa
     8401 agctttgtgg atattgctat ttgaattttg aaacagaaaa tggatttaaa aagaataaag
     8461 ctgggtgtgc atttcatcgt aatgttgtaa aaacaaattt atcacgatac gtttcaattt
     8521 atgaagaaaa cccaaattgc agatattttc tagatacaga tactgcagaa ttagaaaata
     8581 attaaatgta attcaaagat ataggagctg gaaacaacaa agaaatgaaa tgtaacagga
     8641 aaacgtccac cgaaaagtgc tgttgcagga aagaagtcag taatacaaca aacaaagaat
     8701 gagccagtag tcggcaggaa tattttccag agggcgtgac cctgtttagg agctgagctg
     8761 acaccctggt tatggacagg cgggacgaga gaagttagga ctcggcatag actgatgatc
     8821 ctggtagaca tgggaggttc gctaccgtag atggatgggt atacacaagg ccatgtagaa
     8881 cgaaagacca agacgtttta cttcgtgtac ccaaaatcct ctattttcgt accagataca
     8941 gagaaatgtc cattcctatg gctccttctt ctgagatatt aattgatgaa agattaaaaa
     9001 atccttgatt ttcaaggaaa aaagacttga ctatataggg aggataatat atgtttttca
     9061 gattaaatgc atttgcattt ttggttgcag gagaaaaaga ttatagtatt tatgatatga
     9121 aaaataactt tatctatatg cttaatcgcg aagcaggaat gcttattaaa aggttagaaa
     9181 ataatgtgga cctggatacc ttaaaagaat atgaaaagca caagaatgtg tgtatggact
     9241 ttcttgggat gttggctcaa aaaggacttg gagatttttt tgaaaatgaa gttcatatag
     9301 aaaagtttcg ctttaatgca ccaattcaga aaaaaggtat gcttgaacca gttccacaat
     9361 atgtaaaatg ttatttagag attagcaatg agtgtaattt gaaatgctct ttttgtggaa
     9421 aatcaaaata tataaattgg ctgggatgcc agagctgttt tagaaatcaa aatcatcaag
     9481 aggctagtat taaatacgac aaattagtaa gtgaacttga agagattggt gtaaaagaat
     9541 tgattttagg tggaagagag ccattttgca aatcagaagt tatttacaaa cttatagaac
     9601 agtgcaaaaa aaacagtaga ataaatttga taattactac gcctggaagt gttgaagcaa
     9661 atgaaatatt aaaagtttcc agtttatatg aaaaaataaa attaaacatt gttgtttttg
     9721 ccacacgtag attttctgag tttttgagtg aagaaatgca ggagtttata cgaaaacaag
     9781 aaaaactatt cagcgtacta cacaagaata atataccgta ttccgttact ttacagatat
     9841 atgacaaaaa tcggaattat gcagaggcta ttattaggga tattaaaaca gaattgggta
     9901 taactcctat gatagctgat attgtggaca tggaaaaaag agaaaaattg acacatattg
     9961 gaatgaatca aaagatgcta tctcagtata gaaatccgcg agaattttat ttgagaaaaa
    10021 gttataatcc atgcttatac ggtgtttttt ctattgattt atttggaaat gtgaatccgt
    10081 gtccgggaat acataaagca ttaggaaata taaccgacaa tacactgcat gaaattctaa
    10141 gtaaagatga cctttattct tattggactt attcaaaaga taaagttgtg tattgcaaga
    10201 attgttctat gagatatttt tgttctgact gtagtgtgtt tgaattagcg tctcacgaaa
    10261 gttcaaatgt acataatatg ttttgtccgg caaatattga agaaaaagct agtgatatct
    10321 caaatgtgga attcgttggt tggaacaaag agtatttgag cctcgactat taaacgatta
    10381 taatgctatt ttatagcttt ataataaata aacgaaagga ggaaatgtga tatgggagaa
    10441 gtaatgccag tagataactg ttc
//
