LOCUS       c00161_gnlPro..        13532 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MODHNEPK_161.
ACCESSION   c00161_gnlPro..
VERSION     c00161_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:02:06
            Original ID  :: gnl|Prokka|MODHNEPK_161
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13532
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..156
                     /locus_tag="ctg161_1"
                     /transl_table=11
                     /translation="DTELFRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKPIEEI
                     IKRESF"
     protocluster    1..13532
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9054:13530]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9055..13530
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13532
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13532
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             158..724
                     /locus_tag="ctg161_2"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSTKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             769..2493
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg161_3"
                     /sec_met_domain="ILVD_EDD (E-value: 5.2e-184, bitscore:
                     602.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAKEELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMEEIKEFLHLDVMTVTGKTLEE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPFHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLD
                     IIGTDSIERSVEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             2519..3547
                     /locus_tag="ctg161_4"
                     /transl_table=11
                     /translation="MRKNITILVSLLILSLTACSDKAQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISQKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             3556..3933
                     /locus_tag="ctg161_5"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(3936..4517)
                     /locus_tag="ctg161_6"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRVIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPVNREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(4555..5076)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg161_7"
                     /sec_met_domain="HAD_2 (E-value: 5.1e-09, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             complement(5069..5836)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg161_8"
                     /sec_met_domain="F420_oxidored (E-value: 1.1e-09, bitscore:
                     28.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEDFTARY
                     GVVYPLQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPARAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             complement(5833..6393)
                     /locus_tag="ctg161_9"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             6515..8926
                     /locus_tag="ctg161_10"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISVIYSCLGYNKAERIIPSAQADMRLNVQMNNTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPDDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRKVDKDENGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRDFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             9055..9465
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_11"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.4e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             9502..11055
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_12"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-292, bitscore:
                     960.1, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASIHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             11077..11970
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_13"
                     /sec_met_domain="OAD_gamma (E-value: 4.8e-12, bitscore:
                     36.4, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLLMVLFSMGAKAQLTTSVKLNEVLVVNEDNFVDDY
                     GKRHPWFELFNNSAGTVDLRGCFLTNDKSNPRKYMIPKGDVLTKVPPRQHLLFWADDQP
                     TKGTFHVNFTFDPNKDNYLALYDSDGTTLIDEVTIPAGQKADVSYGLDLDGVGNWSILD
                     KVTPSTNNLTLDSNAKLENFQRNDPWGIGMTITAMAVVFLGLMILFLVFKQIGNAAIKA
                     SKRNAQKAAGTGAAVSANIGQESGEIFAAIATALYEMSDDNHDIENTVLTIHKVQRSYS
                     PWSSKLYSLRQTPNKK"
     CDS             11994..12425
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.7; E-value:
                     3.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_14"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.6e-21, bitscore:
                     63.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNTYKVHINSVVDDVAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTNASGEPVITRQAAPSVAGAVKSPLPGVILSVDCKVGDTVKRGQKILV
                     LEAMKMENNINADRDGKIVEIKVNKGDSVLEGADLVVIG"
     CDS             12430..13530
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_15"
                     /sec_met_domain="OAD_beta (E-value: 4.5e-145, bitscore:
                     472.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLQFLGENIQIFLSYTGFANATPGHIVMLLVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQLGIYEEGSVLNILYQGVKQGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYIIALQMGFDPSQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERVIRMKPPRAVSQTEKIVFP
                     IVGLLLTAFLVPSGLPLLGMLFFGNLIKESGVTRRLAETARGPLIDVITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKEGNKINPLIGNSGVSAVP
                     DAARISQNVGLEYDPSNYLLMHAMGPN"
ORIGIN
        1 gacacggagc ttttccgtaa acattttaaa attccggaaa cgatcgagcc tgttgtactg
       61 ataccgttcg gctatccttc cgacccggca ttattcgatg agactccaaa gaaacgtaag
      121 cccatagaag aaattattaa acgggaatca ttctagtatg ttatacattg aagttctgct
      181 actagcgatc ggcttatcca tggatagcct agcagtatca gttaccggcg gcgcagttct
      241 taagaacaac tgcaccgccg gtaatattat taagatagcg agcgtgctcg gtatattcca
      301 agccggaatg accgtgattg gttatacgat gggattagga ttcgaaaaat acatttgcgc
      361 cttcgatcat tggatcgcat ttaccctctt gctttactta ggtggaaaaa tgatatacga
      421 tagcacgaag gaagaggagg aagacgggaa attcgatcct ctatgtaacc ggacattatg
      481 cggattggga atagcgacaa gtatcgatgc cctcgccgta ggaatctctc tggcgatctt
      541 aaaatcaccg ctcttgctgc aagcctcgac tatcggtgtt gtcaccttcg ctatctctgc
      601 cttcggcgtc tatttcggta accgattcgg caagagaatc gacttgaagc tggacctcat
      661 cggaggttta atcttaatcg gtatcggtac aaagattttg atagagcatg tattctttag
      721 ctagggatac cttattgaat aaataacctt atacattaat taatagacat gaaaagccag
      781 caattacgaa aactagcgcc ggagctggat tcactccggc taggcagcgg ttggaaaatc
      841 gacgaattga gtaaaccgca aatcattgta gaaagcagtt acggacatag ccatccggga
      901 agcgcccatc tggataaatt ggtggacgag gccggaatcg gtataaagga aaagggggga
      961 cgtgccgcaa actacttcgt cactgatatt tgtgatggag aggcgcaggg acacgatggt
     1021 atgaactact cattagtctc ccgtgatatc atggccgcca tgatggagat tcatgtaaaa
     1081 gcgactcctt tcgacgctgg tgtctttata gccagttgcg acaaatccgt ccctgcgcat
     1141 ttgatggcga tagcccggct agatatgcct gctatattca tgcccggtgg tataatgaaa
     1201 gccggtccca acctactcac gttagaacaa atcggtacct atagcgccca atacgagcga
     1261 aaagaaataa cggaagaaca attcatggtt tataagcgtg acgcatgtcc ggattgtgga
     1321 gcttgctctt tcatgggtac cgcctctacg atgcaagtaa tggcagaagc gcttggcatc
     1381 gctttaccgg gctccgcctt gatccccgcc catttacccg agttaaaaga aaccgcccgt
     1441 aaagccggag aacatgcact cggactggcg aaagaagagt taaaaccctc cgatatcatg
     1501 acgatacaag catttgaaaa tgcgatcatg gtacatgccg ccatagcggg ttccagcaac
     1561 agcctgcttc atcttccagc tatcgcccat gaactgggaa tccagttatc accggatttg
     1621 ttcgacaaga tacatcgtaa gatcccctac cttttaaata tacgtcccag cggtttttgg
     1681 cccggcgaat atttctggta tgcgggaggc gtaccggcga tcatggaaga aatcaaagaa
     1741 ttcctccatc tcgacgtcat gactgttacc ggcaaaacat tggaagaaaa cttaaaagat
     1801 ttacaactca acggcttcta tgagaattgc cataaatatc ttcctgccct aggagtaaag
     1861 gttggcgata ttatcaaacc ttttcataca ccgatcaagg cacaaggagc catcgctata
     1921 ttgaaaggaa atttagcgcc cgaaggggca gtcgtaaaac attcggcgat ttcaccccgc
     1981 ttgatgcaag tcaccctgaa agcgagggta ttcgattgtg aggagaacgc tattgaggcg
     2041 gtattacaaa agaaaatcca tccgggagaa gcggtattta tccgttatga aggaccgaaa
     2101 ggaagtggaa tgccagaaat gttttatacg acagaagcga tcgcctccga tcctgagttg
     2161 gtagagacca tcgcattgat caccgacggt cgtttctccg gagcgacccg aggcccggcg
     2221 atcggacatg tatccccgga ggcttccgag gggggaccaa tcgccttggt cgagaacgat
     2281 gacttgatcc gtatcgatat tccagcgaga acattggata taatcggtac cgacagtatt
     2341 gagagaagcg tggaagagat agaaaagatc ctatccgaaa ggcgtgcaca ttggataaaa
     2401 ccagagtcac aatataaaaa aggaatcctt gatatttata cacacaatag cgtctccccc
     2461 atgaaagggg catatatgga attttttatg taagttcgcg acataaaatt tcataatgat
     2521 gcgcaagaat attaccatat tagtcagcct gttgatctta tcgcttacgg cttgctcgga
     2581 caaagcccaa tatttcgaag agagtggttc tgtttttcat acaagttacc acatcaaata
     2641 caaggccaag caaatcctaa ccgataagat cgacagcgag ctgcaacgtt ttaacctctc
     2701 cttaaatcct ttcaacccca actccacgat cgcgaaagtc aataataacg aggatgtgga
     2761 ggtagacgaa tggtttaccg aagtattcaa taaggcggaa gaaatctccc aaaaatcagg
     2821 aggagctttt gatattactt gtgctccatt aattaatcta tggggattcg gattcagtaa
     2881 gatggatagc gtaaccccgc agatgatcga tagcataaag gctttcgtcg gttatcaaaa
     2941 agtgagattg gaaggaaaga aaatcatcaa agaagatccc cggattctat tgaattgttc
     3001 gtccatcgca aaaggttatg cttgcgatgt tatcgcccgc ctgctggaaa aggaaggtgt
     3061 aaagaactac atggtagaaa taggtggtga ggtcaccatg aaaggcgtaa atcaacaagg
     3121 tgactgttgg cgagtcggca tcaacaagcc ggaaataggg acaagcggcg taacaaatga
     3181 tgttgaagag atcgtacaat tatgccaaaa aggaggtgtg gctacttctg gtgactaccg
     3241 aaacttctac atcaaggatg gtaagaaata tgcccatacg atcaatccgg cgaccggtta
     3301 tcccgctgga caaaatattc ttagcgcgac aatcgtggcg gaagattgta tgacagcaga
     3361 cgcttacgct acgactttca tggttttggg agtcgagaaa gcgaagctac tggcacaatc
     3421 catcccccaa atagagtatt tcattattta tgcggacaac aacggacaac agaaagtcac
     3481 ctactcaaaa ggtatgttgg aataccttcc taacagaaaa acattggcta tcctcgaaaa
     3541 tccttaagtt cctacatgaa gcgttatcta aatcaacttg aatgcaaaat actgagagcc
     3601 ggagattccc tgtttaatac cacaaccacg gataacctat taatcttcgt attttcggga
     3661 aaacttatta tttacagcca agaagggaca catatagcgg aagtggcaaa agatcatttc
     3721 atgctacttg cgcaaaacac caatcataag gttatagcct cagcccctac ccgccttatc
     3781 ttaatacatg cgggcagctt atccgacatg atcataaatg acccggaatg gaatgtggag
     3841 aaaccggtcg tcttaccgat tcccccagcc ttagcgcaca cattaaatca gatagaatat
     3901 tatatgaagg ataaatactt taccttgaat tgagattaaa aatgtttcaa ttcctgataa
     3961 agcttttgca caggtaatcc catcacgtta taaaagctac cattgatagc ctctaccccg
     4021 atataaccga tccactcctg aatgccatac cctcccgctt tatcataagg tttatattta
     4081 tccaaataat aattaatctc ttcatcaccc aattttgcga aacaaaccgc agattcgacg
     4141 gaaaagccta catttttgtc cttcgtcatg atacaaacgc cggttattac ctgatgtaca
     4201 tgatccgaca aagcatgaag catagcataa gcttcctccc ggttcacagg cttccccata
     4261 accccgtcaa acgtccagac gatcgtgtcc gccgtgatca gcaattcatc atctgccata
     4321 gtcgatttat aggcctccgc tttcgaacgg gcaatatata aagggatctc catggagtca
     4381 atagaatccg ggtaagactc gtcaatatcc ggaattaccc tcacctcgaa gtcgatatcc
     4441 agaccagata acaaattccg tcgtctcgga gaattagagg ctaagacgat cttgtacttt
     4501 tttaaattct ctaacataac ctattcgatt aagcgttaca cattcaccaa aattttacca
     4561 cccaaaagcc tcctcgccga accagtgtcc ttgcgcccgc atcgtttgct cgatcacgtc
     4621 cctagctacg ccttcgccac ctcgccggga ggatatatat ttcgctatct ccttgatctc
     4681 cggagccgca tccgcaggtg ccaccggcaa tccgactcgc gtcattacct cataatcagg
     4741 aatatcatca cccgcataca tgatttgctc aggagacaag cccgtttttt ccatgaaatc
     4801 cttaaagtca tgcaccttta cagcgctacg catataaata tgttgtattc ctaaacgaga
     4861 aaagcgaatc tgtacggctt ccgtatatcc gcccgtaatt atagcgacct cataaccttt
     4921 cttcacggcc aattgcaagg catagccatc cttgatattg accgtacgca tcggatcgcc
     4981 attcgggtga agcggaatca catcgcagga tagcaccccg tctacatcaa agacaaaagc
     5041 ctttattttt ctcaaatcat agtttatact actcatgtcg agcctcctta tgtatacttc
     5101 ggctaatcag ctcatataaa tttcgcatat ccggatcttt aagcatagcc atatgtttgt
     5161 ttatcacatt ctcgtcatat cgtatagctg gtcccgtttg ggctcgcgcc ggtgacatta
     5221 catgtacctt agcggctgtc tcgtctatca aaggtagcaa gacctctccc ggtatttgct
     5281 gttcttccaa gatcttttca gctagcgcat acatatgatt cgtaaaatta caagcgaaaa
     5341 ccgccgctaa atgtaagttc tttcgcttct cggaggagag gaaacggaca tcactggaga
     5401 gcgccctagc cacctctccc agcaccttct catcttcaga cgagttcgcc tctaaaaaga
     5461 acggtatttt cttgaaatcc acctccctac tcttactaaa cgtttgtaac ggataaacca
     5521 ccccatatct agccgtaaaa tcttcaaata cagagattgg catactccct gccgtatgca
     5581 cccacaaacc gttattcggt tttacacggg cgataacatc ttggagcacg gcatctttca
     5641 aagagaaaac atacaagtcg gcatcttcca caatatcttc cgggacaaca gtccacccac
     5701 atcccaattc atcggctaaa atcttagcat gctcacttgt gtgactatac acttgcccga
     5761 tactcattcc ggacttacgc atttccaacg aaagccgggt agctaagttt ccggcaccaa
     5821 caaatacgac tctcattctt ccgcctcttt attttcttcc ggaagagaga actttcctat
     5881 atgtatcttc tcccattgta aatgggattc atcaaaaggc ttacgaacct gatccttata
     5941 accgatacca atgatagaca agacatccaa ttgataaggg atatccagca acgaacgaac
     6001 ataattattc gaatccgcct cgtcctctgt tacccggttc cggatctgac accagcaact
     6061 gcccaatccc aaatcctccg cttgcaattg catataaata gaagcgaccg aagcgtcctc
     6121 gatccaaaca tcgctttcca tcacattcgc caagacaacc acggccaagg cacaaccctc
     6181 cagaaaagca gaaccatttt tcttacaccc ggcaagtttc ttcaacattt ccttatcttc
     6241 cacgaccacg aactgccaag gattactacg ttttgaggcc ggagccatca acgccgcttt
     6301 caagatcagt tctacctgct cgggggaaag tagttgttcg gtaaacttac gtgtacttct
     6361 tctattttgt ataagtgttg caaaactctc catttttttc gttctttgta ctcttttaat
     6421 attaagattc gcaaatataa atataatttt ttgcacccat atatacgtat cgttcttttt
     6481 tctcgttagt atttttataa ttgaacaata gattatgaag attcgtgcga tagccgcgct
     6541 gctatttata cttatttccg tgagtgcctt tggcgaaggc cgcataaaaa tcactggtta
     6601 tgtccgtgac gccgacggta accctctgga attagtgaat gtccgggtta agaacacgtt
     6661 gatcggctcc atgaccaacg agaagggata ttattccttt tccatatcgc cgggggattc
     6721 tatctccgtt atttactctt gtctgggata taataaggct gagcgtatca ttccctcggc
     6781 acaagcggat atgcgcctga acgtacagat gaacaatacc tcatttgatt taggggaagt
     6841 atctgttact gccatccgca agcagaccac gaccatggag tccctaaatg cggacaaaat
     6901 caagttattg cccgatccct ccggaggtag tatagagagc ttggtcgtta cgtttgccgg
     6961 agtatcgtcc aataacgagt taagttccca gtattccgta cgtggaggta gttatgatga
     7021 aaatatcgtt tatgtgaatg ggatcgaggt attccgtccg cttctgattc gctcgggaca
     7081 acaagagggc cttagcttta tcaatccgga cctgacagag gcggtcaatt tcgccgccgg
     7141 tggcttcgag gcccgttacg gagacaagat gagttccgtg ctggatatta cctataaaaa
     7201 gcctaagata ttcgaaggct cggcttccgc gagcttgttg ggtgcgaatg cttatgtagg
     7261 cagttctatc ggtaaattta cccaagtaac gggtttccgc tttaaaagcg gtcggtctat
     7321 tttgggtacc atggatacag acgcagaata cgaccctaaa tttatcgatc tgcaaactta
     7381 catcacgtac caattggccc ctaaatggga aatcaatttc ttgggaaacc tcgctaacaa
     7441 taattataaa ttcacccctt atagccggga aacctctttc ggtacagccg agcatcccaa
     7501 gaacttcaaa gtctatttcg acggaaggga aagagaccgt ttccaaacct tattcggtgc
     7561 gcttacattg aaacacaacc ccaatgagaa cacagagttg ggacttcaag cctccgcttt
     7621 caaaagcaag gaagaagagg gatacgatat cgccggagaa tattggctga gcgagaacgg
     7681 agcggaaaat ccggatgacg acgcgtcagc cgccatgtcc gtaggccgtt atcacgagca
     7741 cgcacgaaac cgtttgaact ccaccgtcat gaatgtcggg cattatggga tggcccgcct
     7801 tttaaacaat acgttgaaat ggggagccac ggtacaaatg gagaaaatca atgataagat
     7861 cagtgaatgg gaaaaaaggg attcctcagg ttattctttg ccccaaaccg gtaataacgt
     7921 aagtgtatat tcgaacctct tttctgataa tcagatagaa agcacacgct tttccgctta
     7981 tgcgcaagac gcgttcaaat tcaggaccaa gcaaggtctg ttcacgttag tcgcaggagt
     8041 tagaggtagt tattggactt ataataagga gttccttttc agtccccgtg cctcattggg
     8101 ctttatcccg aacttcgacc aagacttgac gctccgtttc gccaccggac tgtattatca
     8161 atcgcccttc tacaaggaat tacgtaaagt agacaaagac gagaacggca ataatatcac
     8221 ggtattgaac aaagatctaa agtcacaacg ctccatccat ttcatattgg gaggagatta
     8281 tacgttccgt gccgtagacc ggaatttcaa ggtgaccgcc gagatgtact ataaaaagct
     8341 ggacaatctg aatccctaca ccgtagataa cgtcaagatc cgctattacg gcgagaactg
     8401 cgccaaaggt tacgccatgg gactcgatgt caaattcttc ggagaattcg taccgggtac
     8461 cgactcatgg atcagcttct ctttgatgaa agcccagcaa accatccggg aaacaacgac
     8521 cgttcctatg gccaatagcc aaggctacaa catctcactc ttcttccaag attatttccc
     8581 gggctataaa cgagtcaagc taaatctgaa aggagttcta tccggaggac ttccccagac
     8641 aatcccgggc aaaggatacg aagccggcta tttccgtacg cccgcctaca aacgtgtaga
     8701 tatcggcctc tcctatcaat tggcaggagg cacggacgct atcatggaca gggacttctt
     8761 ccgccatttg aaaaacattt ggctaggtct ggatgtgttt aacatattag acatcaaaaa
     8821 cgttagttcc tactattgga taacagatgt atataatgtc caatacgcag ttccaaacta
     8881 tctgaccgga cgtcaattga acgttcgtct gattgtcgat ttttaataaa atgtatcttt
     8941 aaacacattt actgggagat aaaaacaaaa aattatttcc tcattcataa aaagtagtgt
     9001 acatttgcac acaatagaaa caaacattta ctaaatcttt aaattattat tgacatggaa
     9061 cttacacata tcgaacattt aggtatcgca gtgaagagta tcgaggcttg tttaccctat
     9121 tatgaaggcg ttcttggatt aaaatgctac aatatcgaag tagtagcaga ccaaaaagta
     9181 aaaaccgcat ttttcaaggt aggacagact aaaattgaat tactagagcc gaccagcgaa
     9241 gatagcacga tcgcgaaatt tatcgagaaa aaaggtgaag gtatccacca tatcgcattc
     9301 gcggtacctg atgtacaggc agctttgaac gaggctgagg aaaaaggcgt taaattaatc
     9361 gataaagctc cccgtggtgg cgcggaaggc ttgaacatcg ctttccttca cccgaaatca
     9421 acttgcagcg tattgacaga actttgcatg ccgggcaaca aataattaat ccgttcattt
     9481 ctaacaacaa atcaaaatac aatgagtaac cagcttgaaa aagtaaaaga gctcatcgca
     9541 cttcgtgagc aagctcgctt gggtggagga gagaaaagaa tcgaatcaca gcacaaaaaa
     9601 ggcaaatata ccgctcgtga gcgtatcgcc atgttgcttg acgaaggtag tttcgaggaa
     9661 ttcgacatgt ttgttcaaca ccgttgtaca aacttcggta tcgagaaaac taaatattta
     9721 ggcgatggta tcgtaacagg ttatggtacg atcgacggac gtttggtata tatcttcgct
     9781 caagatttca ccgtattcgg tggagccttg tctgaggctt tggctatgaa gatctgtaaa
     9841 gtaatggatc aagccatgaa gatgggcgct cccgttatcg gtttgaacga ctccggtgga
     9901 gctcgtatcc aagaaggagt aaatgccttg gcaggatacg cagagatttt ccaacgtaac
     9961 atcttggctt ccggtgttgt tccccagatt tccggtatct tcggtccttg cgccggtgga
    10021 gccgtttatt ctccagcttt gacagacttc aacatcatga cacgtggtac cagctacatg
    10081 ttcttgactg gtccgaaagt cgtaaaaacc gtaacaggtg aggatgtaac ccaagagcag
    10141 ttgggtggag ccagcataca cactacaaaa tcgggtgtag cccatttcgc tgttgataca
    10201 gaagaggatg gtttgcaatt gattcgcaaa ttgctcagct tcttaccaca gaacaacttg
    10261 gaggaaactc cgctagttga gtgtaaagac ccgatcgatc gtttggacga tgtattgaac
    10321 gatatcattc ctgataacgc taaccaatct tacgatatgt acgaggttat cggtacgatc
    10381 gtcgataaca acgagttcct agaggtccat gcggactacg ctaagaatat tatcgtaggt
    10441 ttcgctcgtt tcaacggaca atctgtcggt atcgtagcca accagccgaa ggttatggca
    10501 ggatgcttgg atagcaacgc atctcgtaaa gcaggtcgct tcgttcgttt ctgcgacgct
    10561 ttcaatattc ctttggtaac attggttgac gttccgggat tccttccggg tacaggtcag
    10621 gaatacaacg gtgtaatcct tcatggcgct aaattgcttt acgcttatgg tgaggctacc
    10681 gttcctaaga ttaccgttac attgcgtaag tcttacggtg gagcttattg cgtgatgagt
    10741 tctaaacatt tacgtggtga tatgaattac gcatggccga cagccgagat cgccgttatg
    10801 ggcccgagcg gtgccgtaga ggttatcttc gccaaggaag tagcagccgc tgaagatccg
    10861 aaagcatgcg cagcagagaa agaggctgaa tataagaaag cattcgctaa tccttataac
    10921 gcagctcaat acggttatat cgacgatgtt atcgaaccgc gtaacactcg tttccgtatt
    10981 attcgtgctt tgcagcaatt gcagactaag aagttaagca atcctgctaa gaaacatgat
    11041 aacctgcctc tataatccgt aaaacaggag atgaatatga taaataagaa aataggggta
    11101 ttgctactgt taatggttct cttcagtatg ggagccaagg cacagttgac tacctccgtt
    11161 aaattaaatg aagtgctagt tgtcaatgaa gataactttg ttgatgacta tggaaaacgc
    11221 catccatggt ttgagttgtt taataactca gcaggtacgg tggatttacg aggatgcttc
    11281 ttaacgaacg ataaaagtaa tcccagaaaa tatatgatcc cgaagggaga tgtacttacc
    11341 aaagttcctc cccgccagca tcttcttttt tgggcagatg atcagccaac aaaagggaca
    11401 tttcatgtaa acttcacatt cgatccaaac aaagataatt atctggcctt atatgattca
    11461 gatggtacaa ctttgatcga cgaggtgaca atccctgccg ggcaaaaagc agatgttagt
    11521 tacggtctgg atcttgatgg agtaggtaat tggagtatcc ttgacaaagt gactcctagc
    11581 accaataatc tgacgctaga ttcgaatgcg aaacttgaga atttccagcg gaacgaccca
    11641 tggggtatcg gtatgaccat tacagccatg gctgttgtat tccttggctt gatgatcttg
    11701 ttccttgtat tcaaacagat cggtaacgca gcgatcaaag ctagcaagcg taacgcccaa
    11761 aaagccgcag gaacaggtgc tgccgtatca gccaatatcg gtcaagaatc aggtgaaatt
    11821 tttgccgcta tcgctaccgc tctttatgag atgagcgatg acaaccacga tatcgagaac
    11881 acggtattga ctatccacaa ggttcaacgc agctattcac catggagttc taagctttat
    11941 tctctgcgtc agactccaaa taaaaagtaa tcatcctaaa atccaattga cgaatgaaaa
    12001 gttttaaata taccattaac ggtaacacat ataaagtaca tatcaactca gttgtagatg
    12061 atgtggcaga ggtagaggta aacggaaccc cttataacgt aaaaatggag aaacctgcga
    12121 aaaaacaaat ggttacattg aaacgtccgg ctcaagctcc gaccaatgcc agcggtgaac
    12181 ctgttatcac ccgtcaagca gctccaagtg tagccggcgc tgttaaatct ccgctgccag
    12241 gtgtaatttt aagtgtagac tgtaaagtcg gcgatacagt taagagaggc caaaagatct
    12301 tggtattgga agccatgaag atggaaaaca acatcaatgc cgatcgtgac ggtaaaattg
    12361 tagaaattaa agtaaacaaa ggcgactctg tattggaagg tgcagatctc gttgtaatcg
    12421 gttaatgata tgcaagaaag tttcttacaa ttcctaggag aaaatatcca aatatttctc
    12481 tcctatacag gatttgcgaa cgcgactcca gggcatatcg tgatgctatt ggtaggtttg
    12541 ctgttcatat tcctagcgat taaatatgaa ttcgagccaa tgcttctgat ccctattggt
    12601 ttcggtatct tgatcggaaa tatccctttc aaggatgccg gattacaatt aggtatatac
    12661 gaagagggtt ctgtattgaa cattttgtac caaggagtga aacaaggttg gtatcccccc
    12721 ttgatattcc tcggtatcgg tgccatgaca gacttctccg ctttgatatc caaccctaag
    12781 ttaatgctag tcggagctgc cgcccaattt ggtattttcg gtgcttatat cattgcattg
    12841 caaatgggat ttgacccaag ccaagccggt gctatcggta ttatcggagg agctgatggt
    12901 ccaactgcaa tcttcttgtc atccaagtta gctcctaact tgatgggtgc tatcgctgta
    12961 tccgcatact catatatggc attggttcct attatccagc caccgtttat gagattgctt
    13021 acaacgaaga aagaacgtgt gatacgtatg aaacctccaa gagccgtttc acagacggag
    13081 aaaatcgttt tcccgatcgt tggcttgcta ttgacagcct tcttggtacc gtctggtttg
    13141 ccattgttag gaatgttgtt cttcggtaac ttgatcaagg aaagtggtgt tactcgccgt
    13201 ttggcagaga cagcccgcgg cccgctgatc gatgttatta cgatcttgtt aggcatcacg
    13261 gtaggtgctt ctacacaagc tacccagttc ttaacattga actctatcaa gattttcggt
    13321 ttgggtgcgt tgtcattcgt tatcgctact tgtgccggtg tattgttcgt taagttcttt
    13381 aacctgttct tgaaagaagg caacaagatc aatccgttga tcggtaactc cggtgtatcc
    13441 gccgtacctg acgctgcccg tatttcccag aacgtaggtt tggaatacga tccaagcaac
    13501 tacttgttga tgcacgctat gggtccgaac gt
//
