LOCUS       gnlProkkaJCBPBLJP_22   13215 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JCBPBLJP_22.
ACCESSION   gnlProkkaJCBPBLJP_22
VERSION     gnlProkkaJCBPBLJP_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 21:47:48
            Original ID  :: gnl|Prokka|JCBPBLJP_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13215
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13215
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3901:8215]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3902..8215
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13215
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13215
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..97
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MNSYLPSVMGCRNCVKSTETFLFVNENTTTF"
     CDS             75..866
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="Poly_export (E-value: 1.3e-18, bitscore:
                     58.2, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXERPE"
     CDS             955..2679
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 70.9;
                     E-value: 1.3e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKN
                     IATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATL
                     IKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNK
                     LEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDI
                     KSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQ
                     AGGLKEAASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQV
                     YVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRV
                     ANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLRE
                     GDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNG
                     QVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2690..3838
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3902..4621
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.9e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4642..5943
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="CTP_transf_like (E-value: 6e-13, bitscore:
                     40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.2e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 6.9e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5960..7084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             7094..8215
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg22_8_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="Aminotran_5 (E-value: 4.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7184..8191
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_8_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg22_8_Aminotran_5.1"
                     /locus_tag="ctg22_8"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             8212..8355
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8594..10042
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_10"
                     /sec_met_domain="Polysacc_synt (E-value: 4.6e-31, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCIL
                     TLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9996..11255
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11264..12013
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             12013..13053
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aagcaacagt tatctgccgt ctgtcatggg atgcaggaac tgtgtgaaat caactgaaac
       61 ttttttattt gtcaatgaaa atacaacgac tttttagcat tctactattt tgtttgatgc
      121 tgggaagtgg ctcgcttatg gctcagtcca tgagtgactc acaggtactg gaatatgtaa
      181 aagacggcat ccgccaaggc aaggaacaga agcagcttgc ttccgaacta gcccgtaagg
      241 gtgtaaccaa agaacaggca atgcgtgtga agcagctata cgagcagcag aacaatgtaa
      301 atacctcgaa atcaacgggc acggacatca acgaatcccg cctgcgtgaa gagactaaga
      361 agaatacttc cgatatgctg gaggatcatc cgactactca ggaccttgcc cgtggtgatc
      421 aggtcttcgg acgtaacatc ttcaataccc gcaacctgac gttcgagcct agtgtcaacc
      481 ttgccactcc tgccaattac cgtcttggtc ccggtgatga agtcatcatt gatatctggg
      541 gtgcgagcca gaacacgatc cgccagcaaa tctctcctga aggtactatc aacattcaga
      601 agatcggccc tgtcaacctt agcggtatga cagtctctgc cgccaatgac tatctgaaga
      661 acgccctgaa taaaatatat aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      841 nnnnnnnnnn ngaacgccct gaataaaata tataacggtc tgaataatac taccgatcct
      901 acttccgaca tccgtctgac gttaggtaat atccgtacta ttcagattaa tgtgatggga
      961 gaagtcgtac agcccggtac ctacgccctt tcttccttct ctaccgtctt ccatgcgctt
     1021 tatcgtgcag gcggtgtgag tgatatcggt agcctccgaa acgttcagtt ggtacgcaac
     1081 ggaaagaata ttgccaccat cgacgtctac gaattcatta tgaaaggcaa cacacaggat
     1141 gacatccgcc tacaggaagg tgacgttgtg attgttcctg cctatgatgt attggtaaag
     1201 attagcggca aggtaaaacg tcctatgcgt tttgaaatga agaaagacga gaaccttgct
     1261 actctcatta aatatgccgg cggctttgaa gctgatgcct acacccgttc attacgtgtt
     1321 gtccgtcaga atggtgagga atacgaagtc aacacagtca aagatataga ttacaacatt
     1381 tataaaatgc gtaacggtga cgtagtaacc gccgaagcca tccttaaccg cttcacaaac
     1441 aaactggaaa tccgtggcgc tgtctatcgt cccggtatct accagctcag cggtaaactg
     1501 aacacgatcc gcgaacttgt ccatgaagct cagggtctga ccggtgacgc tttcctgaat
     1561 cgtgccgtcc tctatcgcca gcgtgaagac ctgaccagtg aagttgttca gatagacatt
     1621 aagtctatca tggacggcac ttccccaaac cttgccctaa tgaagaatga catcctctac
     1681 attccaagta tccatgacct ggaagaccgg ggtaatgtca cagttcacgg tgaggttgcc
     1741 caccctgatt cctatcctta tgcggataac atgacacttg aggatctgat cattcaggcc
     1801 ggtggcttga aagaagccgc ctctactgtc cgtattgata tatcgagacg aatcaagaat
     1861 cctcgtagta ctgcggataa tgatacgatt ggtcagatgt ataccttctc tttaaaggat
     1921 ggttttgtaa tagatggtca gcccggtttt atccttgagc cttatgatca ggtttatgtc
     1981 cgtcgcagtc cgggctatca ggcacaacag aatgtagcca ttgaaggtga aatccttttc
     2041 ggaggaaatt acgccatgac cagccgtgag gaacgtcttt ccgatttagt gaataaagcc
     2101 ggcggtccga ccaattatgc ctatctgcgt ggtgcgaaac tgacccgtgt ggctaacgct
     2161 agtgaaaaga aacgtatggg tgatgtaatt cgccttatga gcaggcaatt gggcgaagcc
     2221 atgattgact ctttgggtat tcgtgttgaa gatactttta cggttggaat agatttggaa
     2281 aaagccttga gcaatcctaa aagtaatgcc gatcttgtct tacgtgaagg tgatgtgatc
     2341 tccataccta agaatactaa tactgtaact atcaatggtg ctgtcatggt tccgaatacg
     2401 gtttcttata tgaagggaaa gaatgtggat tattacctga atcaggccgg tggctgttct
     2461 gataatgcaa ggaagagtaa gaagttcatt gtttacatga atggtcaggt gacgaaggtt
     2521 aagggtagtg gtaagaaaca gattgagccg gggtgtgaga ttattgtgcc tggtaaggct
     2581 aagaagaaag ggaacatagc taatatttta ggttatgcta cttccttcag ttctttggga
     2641 atgatgattg cttctattgc taatttgata aagaaataaa tgacctatta tgattgaaaa
     2701 gcaatcttat caagaaccgt tttctgaagt ggataaaagg aaagatgatg aaatggaaat
     2761 agacttgatg gctatttttt ataagattat tactgttcgt ggagtactat gcaaagctgc
     2821 tggagtggga gtaataattg ctatagtggt ggcattgagc attcccaagc aatatacagt
     2881 aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga agtaatggtt tagccggact
     2941 tgctgcctcg tttttgggag atggggctct aataggggaa agcacagatg ccttgaacgc
     3001 ttctctttca gcagatattg tttcttcaac tcctttttta ttggaacttt tagaaatgga
     3061 agtctccgtt tctaaaaagg atgataaaat gactttgggg tcttatctcg atgaagagtc
     3121 atctccttgg tgggattatc ttataggttt tccgggcata gtaataggag gagttaaatc
     3181 attattcgga gaagatacgg ttcctgccag tggagggcgg caaggaacta tcgaattgac
     3241 gaaagaagta aatgagaaga ttaattttct taaaaagaag attagtgcat ccattgataa
     3301 gaaaaccgcc ataacgagca ttacggtcac cttacaaaat ccgcagatca ctgcggttat
     3361 agcagattct gtcgttcata aattacagga atatattatt gggtatcgaa cttcaaaagt
     3421 aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa cgtcagcagg aatattatgc
     3481 tgctcaaaga aaatatgcgg attatgtaga cgcccatgat aatgtggttc ttcaaagtgt
     3541 acgtgctgag caggagcgtt tacagaacga catgagtttg gcttatcaga tatatagtca
     3601 ggttgctaat cagttgcagg tatccagagc caaagtacag gaggaaaagc cagtctttgc
     3661 agtagttgag cctgccgttg tacctttgaa accttcaggt atgggactca aaatttatat
     3721 tttattattt gtgttcctgt ccgtatctgg tactctcgtg tgggtgtttt ttggcaaaag
     3781 tctgctggct agcttgagaa aagaactgaa aaataaggag atagaacagg ataaatgatg
     3841 ctaaaacgtc gtttacaaca ttcttacatc aattaaattc acttactata ttattaaacg
     3901 aatgatacgt acagctatga taatggctgc gggcatggga acccgttttg gccaatatac
     3961 agaattgata cctaaagggt tcgtcaaagt gggaggtatt ccaatgatag ttcgttctat
     4021 tgatactttg ttatcatgtg acattgagcg aattgtaatc ggtacaggat ataaacaaga
     4081 agtttatgaa gaattgaaga cagactatcc tatgcttgaa acctgtttta gtcctcgtta
     4141 tgctgaaaca aatagtatgt atactttata taatacgcgg gagattctgg gcaatgatga
     4201 ttttttattg ttagagtcag atttgatttt tgagaaacaa gcaataatga gcttattgga
     4261 gtgtcctgcg gcagatgcaa tgctaataac tccagtgaca aagtttcaag atcagtatta
     4321 tgtggaacat gatgataatt ttcgcctttc ttcatgttct gtcaataaga ataaactaaa
     4381 cgctaaaggc gaattggtcg gcatccataa actatccggt tccttttaca aaataatgtg
     4441 tgctgattat gcgagtattg ttgatgaaca acccaatttg ggatatgagt atgaattact
     4501 acgaatatct tgttctcaat ctcctgttta tgtgcataaa gtagaagggc tgaaatggta
     4561 tgaaatcgat gacatatcag atttggaata tgcagagaaa tatattgttc cgtattgtta
     4621 attaaaataa tatatcaaat tatgagtaag acagtttata ttgggatgac tgcggatatt
     4681 atgcatccag gacttatccg cattattaat gaggctacta aatacggtga tgttataatt
     4741 ggtcttctta cagataaagc tattgcggag cataaacgcc ttccttatct gacctatgaa
     4801 caacgaaaag aggtagttca gaatattaaa ggcgtatgta aagttgttcc tcaagaagaa
     4861 tggagctatg ttgagaatct caaacgcatt aaacctgact atataattca tggtgacgac
     4921 tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat ttgaagtgat gaatgaacag
     4981 ggaggaaagg ttatcgaaat tccatatact ttgggaatta attcatcttc tttggataaa
     5041 gatattaagg ctataggtac aacccctgat gtacgtttaa aatcacttcg tcgtttgata
     5101 aatgccaaac ccgtagttcg tattttggaa gctcatgatg gactatgtgg cttgataatt
     5161 gaaaatcagg aaatattaaa aggggataag agggaagtat ttgacggaat gtggtctagt
     5221 agccttacgg attcaaccag taaaggtaaa cctgatattg aggcggttga tttaactacc
     5281 cgattgcaag atttgaataa tattctggag tgtactacta aacctattat ttttgatgga
     5341 gatacaggtg gtaaaattga acatttcgta tttacagtac gcactttaga acgtcatgga
     5401 atttcagcta taataattga agataaagtt ggattaaaaa agaattcatt gtttggtaca
     5461 gatgttattc aaactcaaga tacaatcgaa ggtttctgta ataagatcaa agcaggaaag
     5521 gcatctcaga ttactgatga ttttatgatt atcgctcgta ttgagagcct tatagcggga
     5581 aagccggtaa gtgatgcttt agagagagct tttgcatatg tccaagcggg agcggacggt
     5641 attatgatac atagcaaaaa taagtcgggt gaagatataa aagaattttg tttggcgttt
     5701 cgaaaacagt atgctcatgt acctatcgtg gttgtgccta ctacatatga tcatatttat
     5761 gagtctgaat tgtgtgattg gggtgtgaat ataattattt atgctaatca tatgcttcgt
     5821 gccgcttatc ctgctatgat gaatgtcgca aagataatat tagagaatga acgtgcttta
     5881 gaggtgcgcg aactgtgtat gcccataaaa gaaatattgg aactgattcc aggtactaaa
     5941 taaaaagagg aatatcatta tgttaagcgt agaaaaagtt tatgaaacgt ttctgagtca
     6001 tgacgttgat ttttttacag gagttccaga ctcattacta aaaaatattt gtgcctatat
     6061 cacagaccat acttcacgtg agaaacatat catagctgct aatgaaggtg cggctgtagg
     6121 aattgcttca ggttattata tggcatcagg taaggttcct gtggtttata tgcaaaattc
     6181 cggcttgggt aatactgtta atcctctgct gtctcttgca gatgaacaag tatacagttt
     6241 tccaatgctt ttgatgattg gctggcgtgg tgaaccggga acaaaagatg aacctcagca
     6301 taaaaaacag ggtgaggtaa ctttagattt gttgaaagca atgcggattc cttatataat
     6361 tcttgattca aatgagaatg atgcatttat tcagctccat gatatcatac aatcagcaaa
     6421 aactaagaat attcctcatg caataattat tcggaaagat gtttttggca aatataaact
     6481 tcaaaaagag ttcggatgta attatccttt atctcgtgag gatgctttgc aaatagttgt
     6541 ggattatctg cctgaaaatt cagtggtcgt ttctactact ggcaagcttt ctcgtgagtt
     6601 atttgaatat cgagaaatga aagagcaagg tcatgaacat gattttctca cggtaggctc
     6661 tatgggacat agttcatcaa tctctttggg tattgctata gcaaagcaag atagacctgt
     6721 ttattgcttg gatggtgatg gagcatttat tatgcattta ggggcaatta gtaacattgg
     6781 cgatttatct cctaaaaact attatcatat tttgtttaac aatggtgctc acgagtctgt
     6841 aggaggacag cctactttag gatttagttt agatattccg gctattgtcc gggggagcgg
     6901 atataagcat acttatactg tttgtacaaa agttgaaatt gaagaagcaa tgaagcagct
     6961 tccaaagtta tgtggtcctg ttttgttgga aataaaggtt aaaatagatt ctcgggagaa
     7021 tttgggacgt cccacgacta ctcctataga gaataaggag cattttatgg attttttaaa
     7081 ataaatatat tcgatgaaaa tagaaagaaa aatattatta aatcctgggc ctgccactac
     7141 tactgacagt gtaaaaatgg cacaagttgt tccggatatt tgtcctcgcg agaaagaatt
     7201 cgcaggtatg atgaaacaac ttcgggacga tttggtcaga gttgctcatg ggaatttgga
     7261 aaaacatacc gctgtattat tttgtggctc aggaaccatc aatattgata tatgtctaaa
     7321 ttctcttctt cctgaagaca aaagggtgct tatagtgaat aatggggcat atagtacccg
     7381 tgctgtagaa gtgtgtcaat attatggttt gcctcatatt aatttggaat tttccgttta
     7441 cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa gaaaatcctg atatagctat
     7501 ggtttatact actcatcacg agacgggtac aggaattctg aaccctattc gcgagatggg
     7561 cgctatagct cataaatatc aggctaaatt tgtcgtcgat actacttctt ctttgggcat
     7621 gattcctttt gatatagaga aagataatgt ggatttttgt atggcatctg ctcaaaaagg
     7681 acttcaagcg atgacaggtc tttcttttat tataggcaat gaggaacaga ttaagttttc
     7741 aaaaaaatat cccaagcgtt cttactattg taatctttat ttgcagtatg agaattttga
     7801 gagaacaggt gaaatgcatt ttactccacc ggtacaaact atttacgcca ctcgtcaggc
     7861 attaaatgaa tattttgaag tgggtgaaga agctaagttt gcccgtcaca aaagagtttt
     7921 tgaggctatt cattcaggta taaatgaaat tggtcttaaa agtgtaataa agcgtgaatg
     7981 gcagtcagga ctggttgtct cagttcaata cccagaagat cccaactggg attttgagaa
     8041 aatacatgat tattgttatg agcgtggatt tacgatttat ccaggtaaga tatcaactga
     8101 ggatactttt agaatctgtg ctttaggaga gatagaagta gatgatattg agaacttctt
     8161 taaagtacta aaagctgcat taaatcatta taacgtcaca ttaccgatgt catgattgca
     8221 gaaatattat tgaagattcg tcatttttat ttttcccttc gtggtataca cttccatccg
     8281 gaaagtgtta tttctggagt gcctattcgt agctttcgct tagtaggcaa atatggcaat
     8341 attaatttga ggtgatgcat taggagttct ttattcttat aaaaaggcat cggtagttat
     8401 aggagataat gtttgtgtag ggtaatttgc ttttagtggg agagaccata ttagaattgc
     8461 ggtaaggggc gaagaagata ataaccaatt agtgagaata ttggaaaaat ataattgata
     8521 tcggtaaatg tagttgtttt tatactgtat ttaagtaatg gaaaatctaa agcagaaaac
     8581 tgtatcagga ataatgtgga gcgctataga acgtttctct ttacaaggag tacagtttat
     8641 aattcaaata atattagctc gtttgttact accatcggat tatggtatga tcgggatgtt
     8701 agctattttt cttcaagtcg ctcaagtatt tatagatagc ggttttacaa atgctttaat
     8761 ccagaaaaaa gatagaactg aagaggattt tgccactgtc ttttatttta atattcttgt
     8821 cgcagtatta ttctatggta tattgttttt ttcggcttct ttgattgcag acttttataa
     8881 tatgccgact ttagttcttg taattcgttt tatagcattg tcgttgataa taaatgcttt
     8941 atcggctatt cacagaacga aattaattat ttctgtaaac tttaaaactc aatctaaaat
     9001 ttcattaggt gcagctttta tatcaggcgt gattggaata tggatggctt atgtcggttg
     9061 cggggtttgg gctttagttt ggcaaactct cttaaatagt ataattttga caattttgtt
     9121 ttactgttta gttcattgga aacctttaca tactttctcc aaaagttctt ttgaaagatt
     9181 attcaatttc ggatctaaat tattgatctc aagtcttatc aatacagtat atcgtaatct
     9241 gtataccatt gtaataggaa aaaagttttc tgttgtagag cttggttact atacaagagc
     9301 agaacaattt gctatttttc cttccaataa tttaaatgct ttagtttcta gagtagcgta
     9361 tcctatttta agttccattc aagatgatga taaatgttta acaaacgcat atcgaaatta
     9421 tatcagatta tcctcatata taatttttcc tttaatggta ggtttacttg ttttggctaa
     9481 tcctattatt agtctattgt taacagataa atggtctggg gttgttattc ttttacagat
     9541 attatgtttg gattggatgt ttgatcattt gagccaaatt aatttgaatt tattatgggt
     9601 taaaggaaga tctgatctgt cgttacgtct tgaaataata aaaaagacga ttgctatatt
     9661 cattcttttt gtgtcaattc catttgggct tgaggtgatg tgttggggta gagttattta
     9721 ctctctgata gcgacatatt tgaatacata ttatactaat tctcttattg atttgacctt
     9781 aaagttgcaa gttaaagatg tatttccaag tttaatactc tctttcataa tgggggggat
     9841 cgtttttata tgtatttctt tctttgaaac tgatatagta aaaattgtga ttggatgtat
     9901 tactgggatg tccttctata ttttactttc ttttcttttt aagctagatt cttttttttg
     9961 tattttaaca ttgatcatta aaactaaaaa catagatgaa aatattaaaa aagatttttc
    10021 aagtaatagt aaagataatt aaccattgtg tgccagttga tagtagatca ttgtatttta
    10081 ttcctcatcc taattgtaga acagataaat atgatattat aaattattcg tcagataatg
    10141 ttctcgttct gttaaattat ttgctaaaaa aagatagtgc tgaatattat aaaatatatg
    10201 ttgaaattta tgattcttct cgtatttcag aatatcaaga atatatttat ggcataaatc
    10261 ctaatattag gtgtactttt ttatgtgcat gtgttggacg ttttttcttt aataaagtat
    10321 cttttaagga tatgttgtat gccttttttt gtttttgtag agcaagtaaa tgttttacag
    10381 ctacttttta ttatgatttt tcatttaaaa aacgctctca acagattatt tgtttggggt
    10441 attatactcc attcaaagat gattatcata tgggagatca ttcttatgat aaatttcgta
    10501 atacaacatg taactcattt gattactcta ttgctacttc ttgtttaagt gctagaataa
    10561 tttcaataga ttgtggaatc tcatatgata aattcaaagt cttaggattt cccagaaatg
    10621 atttgttgat atcgaaaaat aattgcaatg ttattaaaag agaaatttcg aaatttgcgg
    10681 gatatgatgt aactaaatat atagtttata ctccaacttt tcgtgattat gagactgtta
    10741 ctgaaggtaa tttgcgttca atactcggat atgttgattg tgatttgttg aagttatcga
    10801 aaatactatt gaagtttaat gcggctttaa ttcttaaatt acatcctttg cagaataaaa
    10861 cagtcttaaa aaaagattta cccaaaggta tacttgtttt tgaacaaaca tataaatatg
    10921 gattgtatga tcttttgtca ttttcagatg gaatgattac tgattatact tctacctatt
    10981 ttgatttttt attggtaaat aagccagtca tatttaattt ctacgatatt gaagaatatc
    11041 gtagagtaag aggtttctca tttgagccaa tagaattttt ttgtgcaggt gatattgttt
    11101 acaattataa tgaattgata gatgctgtga tgggacttct ggctgggaaa gatattcatg
    11161 ctgaacatcg acgtcatatt tctttattga tgaatcaatt tcaagatgat aattcaacaa
    11221 agagaatatg tgacatattt ttaaatgaaa tataataaat aaaatgaatt atgcatttgt
    11281 ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa atattgaaac ctttctatgg
    11341 taatcaatcg attcttgact taatggttca taagctttct gctatatcga atattccagt
    11401 aattattgct acaacaaatt ctgttatcaa tgaacctatt gaaaagaagg cacttgcatt
    11461 aggggtaaag tgcttcagag gtgaggagaa tgatgtttta aaacgattca ttgatgttgc
    11521 tgaatatttt gatatacagg gtatattccg aatatgttct gataatccat ttttagatgt
    11581 acatgcggca aggcaattgg tcgaaatagc aatgaaatct tgtaacgatt atataagttt
    11641 tgatattgat ggtactccat caattaaaac tcatttcggt ttttggggag aatttgtaac
    11701 gcttgatgcg ctgaagcgag ttataggatt tactgatgat ttattgtatc gtgaacatgt
    11761 tactaattat atatatagtc atcctgaact ttttaatatt caatggattt caggatctcc
    11821 agtcgtgtca aaacatcata atattcgact cacgattgat acgttagaag atttttctgt
    11881 agcacagaga atatataggg atttacaaga aaaaagagtg gaaatatcga tagaagtgat
    11941 tgtagactat gttcgaagac atgcagaata cattcaactg atgaaacaac aaataaaaaa
    12001 aaattctaaa taatgaagaa tacttatatt attggtgaaa tagggcagaa tcataatggt
    12061 tctgttgact tggctaagtt gattattgaa ttaatctcac gacctgtaca tgaggatgtt
    12121 tttggtatgg atttcatgcc aatgaatgct gttaaaatga ctaaaagaga tttatcagaa
    12181 gaattggctg tttctcaaat gaatcaaata tatgacaatc ctaattcttt tgggcgtact
    12241 tatggtgaac atcgtgcttt tcttgagctt gatgatcaag cgcattttga gatttataaa
    12301 tatgctaagt cattaggatt agattttatc gagacgttat gtgccaaagg atgtctgtct
    12361 ttgcttaaac tgttcacacc ggataggcta aaagttgcta gtcgtgattt gactaactta
    12421 ccattgcttg aagcattagc agaaactcat attcctatta tattatcgac aggaatggct
    12481 ggtcaaagag aacttgacaa tgcattagat gtgataacga gatatcatag taatatagct
    12541 attctacatt gtgtatctca gtatccaact catccaaata atttgaatct acgtacaata
    12601 acatatttga agaagcatta caataagttt gagataggtt tttctgatca tacaataggt
    12661 atttctgctg ctacagctgc tgtagcgatg ggagcggaaa ttatagaaaa gcatgtaaca
    12721 attgatcggc atatgaaagg aacagaccag cttggctctt taggtccaga tggggttaat
    12781 cgtatgattc gagatattcg catagcagag tgttggcttg gtactgaaga tctttatata
    12841 gaaaaagggg tggagaagtc taagataaaa cttgaacgtt ctattgccac tcgaaaatat
    12901 attccagcag gtagtattat tcaagagtcg gacattcatt tactgagtcc tggtgatggt
    12961 tataaatgga tagataaaaa aaatgtaatt ggtcattttg ctaaacaaga tatatcagcg
    13021 aatgaaataa tatatcctga ttttattgaa tagatatatt cctactgcaa cttgtattac
    13081 ggtatagagt actgcctgct ataagctaag tagtgattaa taaataaggg taaaatacta
    13141 aaaaaatgaa agagataaag cttatactta cagatattga tggcgtttgg actgatggcg
    13201 gaatgtttta tgatc
//
