LOCUS       c00031_gnlPro..        16328 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EOGKMGEJ_31.
ACCESSION   c00031_gnlPro..
VERSION     c00031_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 20:49:49
            Original ID  :: gnl|Prokka|EOGKMGEJ_31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16328
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16328
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2776:6328](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2777..6328
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16328
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16328
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(204..1331)
                     /locus_tag="ctg31_1"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRSSGNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLSEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1566..2744
                     /locus_tag="ctg31_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNLNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2777..6328
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_3"
                     /sec_met_domain="PFOR_II (E-value: 1.3e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.5e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.5e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-12, bitscore:
                     38.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.2e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.5e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNQILEGDNAPAEAKEVLKAWIENMYDADKTKE
                     LAPQIEAIIEQGIAAGCPVSKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6481..7347)
                     /locus_tag="ctg31_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWMVITGWTPHWMFDLFYLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7368..8192)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg31_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.5e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8189..9415)
                     /locus_tag="ctg31_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9714..10052)
                     /locus_tag="ctg31_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10136..11431
                     /locus_tag="ctg31_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNLYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11573..14455)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62.8; E-value: 1.2e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.4e-20, bitscore:
                     62.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYMKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAAYGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 acttatttag gttttaaaaa atattgagta aactaactta ggtataacaa gcgaagttgt
       61 caactaaatc cagtacagta cacacatggc atgtgattac ttgtttcatg caataaaact
      121 ttttgtttct cggtgtggaa ccaatggttt cactacatga aactatcagt ttcacaccga
      181 gaaaccataa cttcgatata atatcacaaa aacacgcttt ttgagataaa cacccacgcc
      241 cgataactac tctttttatg agccggcacc aatgacaaat agcctgattt tattcttcct
      301 tgttctattt ccaaaggata agcctcctcc atttctttgt gtgctctcca ggctgttcct
      361 tccgtagggt aatagcttat ttgaaaagct cctgttgaag taggatagat ataatggtca
      421 taaatatgac gcgctactac tcccatattc atcctcaagt tgatttccac gcaaggatga
      481 atccgataaa caggagattc tggaaagcga cagatcatca tatccactcc caaataacca
      541 ttataaatgg ttccgaaacg gagggataat tcttgttcaa ggcggtcgcg caatttataa
      601 atttcttcga cagggatata ttccgaaaga ttccgttcga tggctgcatc tgaaatcagc
      661 agattacctt cgtacgcccc acttccaccc gtacggaatt gagagtatcc ggcaaaacca
      721 aatcgaccat tacccgaaga acgaaattcc atagcaaaat cttccacctt attatataga
      781 ggttcgccaa taacacctcc ttgctggttg ccaatgcgtg agcaccaacc ggaaatggaa
      841 ggagtatata cacctttgca ccaattcaac ccttttccgc taccggataa aggagctttc
      901 agtaaacaag tatcatgtga ttctacaaat gacttccatt cttcgggaaa cgtcaggtaa
      961 aaagactctc cacaaaaaca ggctcccagt tgtagctgtg gtaataatcc cacagcacag
     1021 gaacgatggg aacagaaacg cagtttatcc aattgctcaa tagaaggaag ctcgctttct
     1081 tccactccca aatccaacag tcgttttctt attgctatat cccagcccca aggacgaata
     1141 tccaaattcc gctccgaagc aagttcaggt tctgtcatca aatcaaccga aagtcctaat
     1201 aattcctgta tcttcttcac atagtcgaga ttataagcgg aaggagccaa tacaacactt
     1261 ccctcttctg cataccacat cggcaacaaa gccaattcgg atgccatctg ccgggcggaa
     1321 gccggtgcca tatagtttgt ttcaccgctg gctaacgcca aatcatgttc cggattgaat
     1381 atataaagag ccttttttgt cattttaaac gaattcaaaa ctttattctg caaatatata
     1441 caggaaatag tcaggaatgg ctacaataaa cagaaagttc taattaaact cacaattttg
     1501 ccatctctac tttgcaaatc ctaaaaaaag cagtatattt gccacccgaa aaacaaagaa
     1561 ctgaaatgga atcattctat cgcacacacg cctacctcgt tgagcacacc aatgcccccg
     1621 ttcgccgcga tcttatggac gagatcgact ggagcgaccg cctgattggt atcaaaggga
     1681 cacgtggcgt aggaaaaacc actttccttc tccaatacgc caaagaaaaa tttgggaacg
     1741 accgctcctg cctgttcatc aacatgaaca acttctactt ctctggccac agcattgtag
     1801 actttgctaa cgaattccag aaacgtggtg gaaaagtatt gttgatcgac caagtgttca
     1861 aacacccgga atggagcaga gagttgcgca tgtgttacga ccgttttcct aatttgaaaa
     1921 ttgtctttac cggctcatct gtaatgcgac tgaaagagga aaatcttgaa ttgcgtgata
     1981 ttgcaaaaag ctataacctg cgcggatttt ctttccgcga atacctgaac ttacaaacag
     2041 gcatgaaatt cagggcctac agtctcgaag aaattcttag cactcacgaa cagattgcca
     2101 aaggagtact ctctaaagtt cgtccgctgg attacttcca ggattacctg catcatgggt
     2161 tctatccatt cttcctcgag aagcgtaact tttcggagaa tttgctgaaa acgatgaaca
     2221 tgatggtgga agtagatatc ctgctcatca aacaaattga actgaaatat ctttcaaaga
     2281 taaaaaaatt actatatttg ctcgctgtcg acggaccgaa ggctcccaat gtgagtcaac
     2341 tggcaagcga catacagaca tctcgcgcca cggtgatgaa ctatatcaag tatctggcag
     2401 atgcgcgact cattaatctg gtttatccga aaggagaaga atttcctaaa aaaccttcca
     2461 agataatgat gcacaactcc aacctgatgt attccatcta tcctgtgaaa gtggaggagc
     2521 aggatgtact cgacacattc tttgcaaatt ctttatggaa agaccataag gtacataaag
     2581 gagataaaaa cgtctctttt atggtggacg aagtaatgcc gttcaaaatt tgccaggaag
     2641 gagcaaagat caagaacaat ctgaatgtga cgtacgcgtt gcataaggct gaaataggtc
     2701 ggggcaacca gatacctctc tggatgttcg gctttttata ttaaaagatt tatttactta
     2761 aatatttaat ttagttatga ctaaacagaa gaaattcatc acttgtgatg gtaaccaggc
     2821 tgcagcgcat atctcgtata tgttctctga agtagctgct atctacccca tcactccttc
     2881 ttcgactatg gctgagtacg tagacgaatg ggctgccgca ggacgtaaga acatcttcgg
     2941 cgaaacagta ttggtacagg aaatgcaatc tgaaggtggt gctgccggtg cagttcacgg
     3001 ttctcttcag gctggtgcgt tgactactac ttacactgct tctcaggggc ttctcctgat
     3061 gatccctaat atgtacaaaa ttgccggtga gttcttgcct tgcgtattcc atgtatctgc
     3121 tcgtacattg gcttctcacg cattgtgtat cttcggtgac caccaagacg taatgtcagc
     3181 tcgtcagact ggctttgcga tgttggctga aggctctgta caggaagtta tggatttggc
     3241 tggtgttgct cacttggcta ccatcaaatc tcgcgttccg ttcatgaact tcttcgatgg
     3301 tttccgtaca tctcacgaaa tccagaagat tgaaatgttg gaaaatgatg atcttgctcc
     3361 gctgatcgat caggaagctt tggctgaatt ccgtgcccgc gcactgaatc cgatgaatcc
     3421 ggttgctcgt ggtatggctg aaaaccccga ccacttcttc caacatcgtg aatcatgtaa
     3481 caactactat gaagcagttc ctgctatcgt agaagaatac atgaatgaaa tttctaagat
     3541 tacaggtcgt aaatacggtt tgttcgatta ttatggtgca gaagatgcag aacgcgtaat
     3601 tatcgctatg ggttctgtaa cagaagctgc ccgcgaagct atcgaccact tggtagcaaa
     3661 tggcgaaaaa gtgggtatgg ttgccgtaca cctgtatcgt ccgttctctg ctaaacactt
     3721 cctggctgct gtacctaaga ctgccaagac tatcgcagtt cttgaccgta ctaaagaacc
     3781 gggcgctaac ggcgaacctc tttaccttga cgttaaagac tgcttctacg gcgcagaaaa
     3841 tgctccggtt atcgttggcg gtcgctacgg tttgggttca aaagatacta ctcctgctca
     3901 aattctttca gtattcgaaa acttggccat gccaatgccg aagaatcact tcactatcgg
     3961 tatcgtagac gacgttactt tcacttctct tcctcaaaaa gaagaaatcg ctttaggcgg
     4021 tgaaggaatg ttcgaagcta aattctacgg tttgggtgct gacggtacag taggtgctaa
     4081 caagaactct gtaaagatta tcggtgacaa cactgacaaa cactgccagg cttacttctc
     4141 ttatgactct aagaagtcag gtggtttcac ttgttctcac ttgcgtttcg gtgatactcc
     4201 gatccgttcc acttatttgg taaatactcc gaacttcgtt gcttgtcacg ttcaggctta
     4261 cctgcacatg tacgatgtaa ctcgtggttt gcgtaagaac ggttctttct tgctgaacac
     4321 tatctgggaa ggtgaagaac tggctaagaa cctgcctaac aaggttaaga aatattttgc
     4381 acagaacaac atttccgtat actatatcaa cgcaacacag attgcattgg aaattggttt
     4441 gggtaatcgt accaacacta tccttcaatc tgcattcttc cgtatcacag gtgttattcc
     4501 tgtagaccag gctgttgaac agatgaagaa attcatcgtt aagtcttacg gtaagaaggg
     4561 tgaagacgtt gttaacaaga actatgctgc cgttgaccgt ggtggtgaat acaagacttt
     4621 agctgttgat cctgcttggg ctaacctgcc ggatgatgca aaagctgaaa acaacgatcc
     4681 tgcattcatc aacgaagtag ttcgtccgat caatgcacaa gatggtgact tgctgcctgt
     4741 atctgcattc aagggtatcg aagacggtac ttggtatcaa ggtacttcta aatacgaaaa
     4801 acgtggtgta gccgcattcg ttcctgaatg gaatccagaa aactgtatcc agtgtaacaa
     4861 gtgtgcatac gtttgtcctc acgcttctat ccgtccgttc gtactcgatg ctgaagagca
     4921 gaagggtgct aagttcgaac aattgaaagc agtaggtaaa gtattcgacg gtatgacatt
     4981 ccgtatccag gttgacgttc tcgactgtct gggttgcggt aactgtgctg acatctgtcc
     5041 gggtaatccg aagaagggtg gcaaagcatt gacaatgaaa cacctcgaaa gccaattggc
     5101 tgaagctgac aactggactt actgtgctga aaacgtgaag actaaacaac atcttgttga
     5161 tatcaagtct aacgtgaaga actcacagtt cgctactccg ttgtttgagt tctctggtgc
     5221 ttgctctggt tgtggtgaaa ctccgtatgt gaaattgatt tctcaattgt tcggtgaccg
     5281 tgaaatggtt gctaacgcta ccggatgttc ttctatctac tctggttcag ttccttctac
     5341 tccgtatact acgaacgaaa acggtcacgg tcctgcttgg gctaactcac tgttcgaaga
     5401 cttctgtgaa ttcggtctgg gtatggaatt ggctaacgaa aagatgcgtg ctcgtatcgt
     5461 gaagttattc aaccagattt tggaaggcga taacgctcct gctgaagcta aagaagtatt
     5521 gaaggcatgg attgaaaaca tgtacgatgc tgacaagaca aaagaattgg ctcctcaaat
     5581 cgaagctatc atcgaacaag gtatcgctgc cggatgtcct gttagcaaag aactgaaagg
     5641 tctgactcaa tatcttgtaa aacgcagcca gtggatcatt ggtggtgacg gtgcttctta
     5701 cgatatcggt tacggtggtc ttgaccatgt aatcgcttcc ggtaaggacg ttaacattct
     5761 cgttctggat actgaagttt actctaacac aggtggtcag tcttctaaag ctactccggt
     5821 aggtgctatc gctaagttcg ctgctgctgg taagcgcgta cgtaagaaag acctcggtct
     5881 gatggctact acttacggtt atgtatatgt tgcacagatc gctatgggtg ctgaccaagc
     5941 tcaaactctg aaagctatcc gtgaagctga agcatatccg ggaccatctt tgattatcgc
     6001 ttacgctcca tgtatcaacc acggtctgaa agcaggtatg ggtaagagcc aggaagaaga
     6061 agaaaaagct gttaagtgcg gttactggca cttgtggcgt tacaacccag ctttggaaga
     6121 agaaggcaag aacccattcc aattggatag caaagaaccg aactgggaag atttccaagg
     6181 tttcttgaag ggtgaagttc gttacgcttc tgtaatgaaa caatatccta ctgaagctga
     6241 agaactgttt aaagctgctg aagaaaacgc taaatggcgt tacaacagct acaaacgttt
     6301 ggctagagaa aactggggtg ctgaataata gtaataccct ataaatataa agcggtaatc
     6361 tttgataaga ttaccgcttt tttattgtat gaactctgtc caacataaac agtactccct
     6421 ttttcccact agagttcatg tctattttat atttaaaatt aaaaataaca atgctccaat
     6481 ctatttattc tctgacttcg gaatccaact atccaccaac agccgatgct catccctcca
     6541 tttgcgggct atttcttctt catccatccg ggcatccttc atagctgtca taaaagagct
     6601 aagttcttct gtcgttagtt tgatgttgcc aaagaattcg gcagcaaacg gatctttctc
     6661 actgaatcct ttccatgcaa tagcatgtat ttcttccaag tctccatata ctttcttcgg
     6721 atcatccaag aatttcaaat aaaacaggtc aaacatccaa tgtggtgtcc accccgtgat
     6781 gaccatccat tctcctttat ccatcgcttt tttcaaagaa gccagcatgg tggaactact
     6841 tgaagtcatg agggtatacc catcaagtcc gtaagcagca atggccttat cggtcgtctt
     6901 cattatccct gctcccgcat caattcctac tatttcagaa gagaaacggt ctttattagc
     6961 ttccagctca ctaatagact ggatcgtaac atattgagga acaactagtc ctacacgggc
     7021 ctctccatat acctcaccca gaaattcgat actgtctcca tactgatcca tataatcttt
     7081 catcgttatt ggtaaccatg catccagaaa cacatctgat ttctttcctg acatagatac
     7141 aaaaataggg gcaagatcag cattttgcaa ttcaacctca tatccatgct cttccaatac
     7201 caccttagcc aaatgactca tggcaatacc ttccagccaa ttggcatagg ctatttttac
     7261 tttctttttc tctaagtctg aattagtaca ggaagctagc aaaagcatag ctgacaatac
     7321 tattcctact attttatata ttctcatacg tattttatcc tttccgttta gttcttattt
     7381 tttcgtcctg ccattccttg cgtgatacgg tctaagatga tagctaaaat aacaactgct
     7441 ataccacctt caaacccaag tccgattttc atttgggtaa tacctttcaa tacaatttct
     7501 cccagaccac cggcagcaat catggcagca attacaacca tagaaagcga catcattatt
     7561 gtctggttga caccagtcag aatggtgggc aacgccaaag gaagctgcac tttatacaat
     7621 aactgccaac gggtagctcc gaacgaacgg gaagcttcca ctacattttt aggaacttgc
     7681 cggattccca atccggtaag gcggaccaca ggaggcatag caaagataat ggtggcaaac
     7741 actcctggca ctgctcccaa tccgaaaaac aaaacagcag gaatcagata aacaaaagca
     7801 ggcatcgtct gcatcaagtc gagaacagga cggagtattt tctctgcacg cgaactgttt
     7861 gccgtccata ctcctaaagg tacaccaaca atcagggcca gacaggtaga tgaaaaaacg
     7921 agagctagag tttgcatggt agcctcccag aatcccattc catagatcag taataatccc
     7981 aatgcggtga aaattgccgt accgcgtcct gctttcatcc atgcgagtgc agcaagtacc
     8041 aaaatggtta tataaaaagg tattccgaaa agtatgtgtt ggaatcctat aataaaacta
     8101 ccgatgcccg cattcacggc atcaaagaaa gtggaaaaat gtatcatcat ccaattgatg
     8161 gccatctcta tatattgtcc tatatttatc ataaatctat tgcgttttga attatttcgt
     8221 ttatttcttc tttatctttc ccggtcactt cgatgattaa ggatgaaagc gggattgttc
     8281 ctaaaaactc gcgcgtctca tcaatcaccc ataccggcga attgctcttt gtcattagag
     8341 gaagtatatc ctccaacacc gtatcctcca acacagaatg tacttctgta cgcacaatcg
     8401 tttcaatgga tttttcctgt ttgctacgta acttaagcaa gtcgttcaga cgtacttctc
     8461 cgaccagttt atcatcggcg tctatgacag gtaatacggt gatattcttc gcacgcatct
     8521 tacgaatcaa tacttcggga ccttctttct tcagacgggc caccaacggt ttgtcaatca
     8581 ttaaagaaga ggcggtaata attttgctcc tatccacgtt ttcaacaaaa cgggctacat
     8641 aatcgttagc cggttcagtc aggatttcct ccgaagtacc tacctgcacc acttctccgt
     8701 ctttcatgat ggcaatacgg tcacctagct taattgcttc actcaagtcg tgggtaataa
     8761 aaacaatcgt ctttttcatc tttgattgca aggccagtag ttcatcctgc atctgtacgc
     8821 gaatcagagg atcgagagca gagaaagcct catccattaa aagcacttca ggattattag
     8881 ccagagcgcg agccagtccg acacgctgtt gcattccacc ggaaagctcg cctaccatct
     8941 gattttcata tcctttcaat ccgacaagct tcatgctttc catcgctttc ttctcacgtt
     9001 cctctttctt cactccctga agttcgaggc cgaacgcgat attgctcaat acggaacggt
     9061 gaggtaacag accgaaattc tggaaaacca tcgccagctc tttccgacga acctgcaata
     9121 attctttttc ggaaatttta gatatatcta ctccgtttac aagcacttgc ccggtagtag
     9181 gacgtatcag acgattgata caacgcagta atgtcgattt tccacttccc gagagtccca
     9241 ttatcacgaa aaactctcct tcattaattg aaagattggc atctttcact cctaccgtac
     9301 aaccggtatc tttcagaatt tcctctttac tcttatcttt tttcaacatc ttgagggctt
     9361 tctgcttctc gttaccaaag ataaggtaca aatcctttat ttctatttta ctcatataat
     9421 atattggttt agattataat atttgttttg ttttcaactg ccgcattcct tattctcact
     9481 tacgataaac aagttgaatg ttcgcatggt tcagtcatgt cacatgataa catgacggtc
     9541 cgacgttttt taaatggtta aaaaaaacag acagagtagt ttaaaaggaa tagaatttga
     9601 taagattatc ctcttaatga acagtagaaa acagtatttt cataaataaa taacagtctg
     9661 ttcttgcata ttgttggcac aaaggtaagg aaaatagatt aaatatgcaa atttcattca
     9721 ggtacggagt aattccaaag atgctttttc aagtctacgc atccattttg tttgaaagag
     9781 atcccttctt ccaacaagag ttgtttctgc tctgtccaac ccggaacaag ccgtcccgac
     9841 gcattgacaa cccgatgaca aggcgcagat aaatcatccg gaatctgttt caaagcacgc
     9901 cccaccatac gggaacattg agacattccc aataatgcgg caattccccc ataggtagaa
     9961 actttaccta ccggaatttc tcggacaacc tgatacacct cttgacaaaa ggatgcggaa
    10021 aggctcgcct tatctacttt ataatctttc atcactcaaa cattacttta tttcagttcc
    10081 aaaactagat aaaaagaaaa gaatttgcaa ataataaaag catttcaaat aaaatatgca
    10141 actttatttg ctttatttac aaataatccc gacctttgta cccattaaaa gcaaccctat
    10201 tattaacaaa acaagcactg ctgttatgaa aaagaaaact atcctgttcg cttcttgttt
    10261 attgggagca ctggctttca gctcctgtga gaagaacctt tatgatgaaa gtaaacaacc
    10321 cgagaaagaa aagaagatga ctgacttgga agtacctgcc gatttcgact ggaaaggttc
    10381 tcaaaatgcc aaagtgaaaa ttgccagtca atcaactgct actatttctg tatttctaga
    10441 agaaaattgc aatgaagagg ctttgatgct tcgaatggat gtcgatgcca acacatcaaa
    10501 attggaactc ccaattgaaa ttcctgcata tataaaaaat gtgtatgtaa aatatggtaa
    10561 tggctctgaa atacaaactg ttcctgttga aagtaatggt actatttcta tagtagtacc
    10621 tgctaacgct acggcattat ccagagttac cacaagagct aataaagaag ttgaaacgaa
    10681 caacatcttc aattatccgg gatatggcaa cggaactatt atgttcgaag atatgtatcc
    10741 agctttaggc gattatgatt ttaatgattt tgttgcatgg tataatttcc aaattgacgg
    10801 tttttattgg agtcacaatc aatgttatgc agaatactta atgataggat tccaaatcag
    10861 agctatagga ggtatatatg actacaatct ttatatccgc ttggcagaag tacaatataa
    10921 tgaacttgat ttagaagaaa ctcaaatgta tcttgagcgt aacaatcctg aagaggctga
    10981 aaatatcaaa atcctaaaag gcccaaaagg ggaattgatt atttcactaa agaaaccggc
    11041 cattcctaac ggatacaagt attataatac ggaggtaaat gaaaaaacaa agcctaaaaa
    11101 aatgatggcc atttacttgg tgttcaactc acctgttaac gttaaaagcc tacaagacag
    11161 taaaatggac ttttatattg caaaaactaa taaaggacaa gaaatccact taaaaggtta
    11221 tagcccggtt tattataaca gcaacgaaag ttatgtaaat gaagacaact ttatatgggg
    11281 attaaaagta cctgcatctt tacatcatgc cagagaagaa gtaaacttct tggaagcata
    11341 tccagacttt gaacaatggg taacatcggg aggtcaagag aaccaaagat ggtggaataa
    11401 gccaaaaacg aataagttga ttatgaatta ataaatatac agtaaatcat atactgaatt
    11461 aaataagagg taaggtatgt caatagattt ccttacctct tatttttatc atatgaattc
    11521 catagaagta taaacagata aatgctcacc accaaatttt gcagattcta tcctatcctt
    11581 tcctcttcaa caaatctgtc ggactctctc caaactgttc tctataacat ttagtaaaat
    11641 aagaaggaga actaaaacca acttcataac cgatctctgc cactgtcata tccgacgagg
    11701 caagcagaga ggcagctttc ttcaaacgag ctatacgaag cagttcattc ggagaataat
    11761 tagtcagaga tttaatcttg cggtaaagtt gcacacgact taatcccata tccttaccca
    11821 aatcttctac attcaaattt gaatctccca tctttgcctc aatcagagct ttgaattttt
    11881 ccacaaagtc tttatccata tcacagacat cctctttcgc caacgtttgt ccgtcaccaa
    11941 aaaactgttt caggcggcgg tgtgaatcta tcagattacg aacgcgtgcc aatagtaatt
    12001 gcgaactgaa aggcttggag atataagaat ctgcaccacc atcataccct tgaattcgtt
    12061 gttcatccaa agaacaagct gtcaatagga taacaggaat atgacaggtt tgtaattcgc
    12121 ttttcaagcg acgacaacat tcaattccat ccattccggg catcattaca tcggagataa
    12181 tcaagtccgg gacatatttc atagctttac gaataccttc cgagccgtat gcagcttcta
    12241 taacagtata atcagtgtga agcaatccat gcacatataa gcgaatatca gcgttatcat
    12301 caataatcag aacgcaaggt ttggaagagt cgtaactttt ttccaattcc tcttcttcgt
    12361 aagttaaagc atcattcaag ctcgaagaac cggaataacc agaagttgca ggagttacgg
    12421 gagccccagc aacggcagag gttgcagcat cggtagaggt tacagaagta gcaggcacag
    12481 agaatgccgg agagttttct gaaacaacag tctcgcaagt ctgtacaggc aaatcaacgg
    12541 taaagatagt tccttgcttt tcatcacttt ccaccgtgat ggtaccttta tgcaattcca
    12601 caaaagcctt taccaatgcc agtccaatac ccgaaccggc atggtgcata tctatcttat
    12661 agaaacggtc gaaaatattc cggatatgct ccgcagaaat cattgagccg gtattggcaa
    12721 cagtaaagcg aatccaacaa tgatcgtctt tagtcaggga agataagcgt acagttactt
    12781 ttccattctc tggagtaaat ttgaaagcgt tggaaaggag gttgaaatag atgcgttcca
    12841 acttttctac atctgccaat gtgcggtaat ccgtatccgg catataatcg aatgagaaat
    12901 gaatatgttt cttccgggct gctgccatga aagactcgtt ccatccctca aaagaagaaa
    12961 gaatgtctaa cgaaatagga gtatattcca tttttccatt ctcgtattta cgaaaatcca
    13021 gaatctgatt gacaagacgc aagaggatat tcacgtttcg ctgaactaac aataacattc
    13081 ggcgctgatc ttcactcaaa gacgaatcag ccagtaaatg ctctaccggg tcggcaacta
    13141 atgtcagtgg agtacgaaaa tcgtgagata tatttgtgaa gaaaaccagc ttggcatgag
    13201 tcgcttcttc cagttgatga gaaagctgga taagctgatc ccgctgttct tcgagtttgt
    13261 cacgctgttc ttcaagaata tcccgttgct cttcgagttt atcgcgctgt tgctctactt
    13321 gtttcttctg ttcggacaac tctttattca ggcgattctt ggaacggagg gatttataga
    13381 ctaccaacaa caatcccgct actaataaaa gaataaccaa gccgccatac atcacgacct
    13441 gctgcgtagc tacacgcgac agatacccac cgatacgtcc gttcaatgtt tcaatcttct
    13501 gatccagttc cgagatatgg gtagtctgaa gttgcataac gtgcgcgttc gtgcggtcta
    13561 caacggcagt attcatgacc gtttcgcgag gataagactt cttctcaaga atattcatgg
    13621 ccagttgcat cactttgtcc ccattagtcg gataaataaa agttgcatcc agcacattgt
    13681 caagcaccaa ttcaagcccg tttcctttgc cgggcagggc atcaatgcca acaaaaatca
    13741 tttccttttc acgtccggct ttcttcgcag cttgataggc tcccggagcg atacggtcgt
    13801 tatgtgcata taccgcatca atcttcggat gacggcgaag catactatcc atttccactt
    13861 ctgccggttc acgttcccag gcagcatccg ctttatcaat cagtttgata tccggataat
    13921 tgctgatagc agccataaat ccctgatggc gttccatggc aggggtggaa ccacccagtc
    13981 cggtaagctc cactacattc cctttccctt tcagacttga tgcgatataa tttcctaccg
    14041 cacgacctat ttcataatta tcggcaccga tataggcagt atatttatca gaaagtatct
    14101 tccggtctac aagaatgaca ggtattcctt tctgataggc ctcctccaca attggagtca
    14161 tgggagccgc ttcattggcg gaaattatca gtaaatcaac tcctttatct ataaaataat
    14221 gaacatcttc cgcctgctta cggttatcat ccgccgccga gcggatttca accgacactc
    14281 catcataaaa catcgcttcg cgaagaatct catcattcat cttgtgccgc caagagtcat
    14341 cactacattg ggccacccca atacggaaac gaggcgcatc ctgacgacag gccgccaagc
    14401 ccaaaagaca aaacaagact gttatccact tcatatattt catcgcttca atcattccct
    14461 ttctttcgta tatcttttgt atttctttct gtaatccaaa tttctctccc cgcattattt
    14521 gcattcacca ccgggaaata catcagttcc actttcacag ggttcagcgt gtattttcca
    14581 gtaaagcgtg aaagcaaagg aaccgtaaac tgataagtac ctaccggtaa tttttcgcta
    14641 aagataacag ttttctcttt aaaatactca cgatatactt cagaacggga gaaattaaca
    14701 ggttttgagg cataactaca acctgccgga acaggaactt cgagcatcac atattgcgca
    14761 ccctcctgtt tcacctgcaa ggtaactgtc aatgtaacag gtacacccgc caccaaagag
    14821 tctttttcca aagtcgcctc caccttgaaa gcatcactct gacgagcatt catcacacgc
    14881 ttcattgaat agacactata caataaaggc tcttttcccg tttttgaaat aagcagactg
    14941 tcgcctgcta tcagccgggc atgataagga aattccgtaa ttcgttgatg atccttaccg
    15001 ctcacagaca ccgacgttcc tgacatccct ccggaacctg ccagcaaatc ggtcagaaca
    15061 gttgccacag ccgaagaagc ctgatacgta ttccatccgc gctccttagt ccgcaaaata
    15121 tacaattgca tattttcttt caacttacac agggaagggt catttttaat aatccggtag
    15181 gctatcaatg tatttatcat ctgatttccc tcccaataat aagtacgccg tccgtcgtca
    15241 cagtaaacac cttccagcat atcctttttc agataaggac gtacgctatc acccacattc
    15301 accgaatcca cctgttgctt gatttcccag agaagcagct tctctttcaa gtatgaaaga
    15361 ggacgataat acttgtttct atttgccaac gagtcttctt tctgttccaa ttgccggacg
    15421 aaaggttcca ataatctgac tgccgaagaa taatccgcct ctactttcca ctcatgcaga
    15481 gcatgaagta tttctatatc ttccagtttc attcctcgat aaggacgcgt atgagcatac
    15541 tccactttca aaccattcag attcaactcc acaggataac ctgcatcttg cgccatcttc
    15601 aaagcccgca gaatatgcgc agacatccag aaagaagtat tttcagagtt cccccaccac
    15661 gaccataact gatgtttgtt ctgatgattc gtcagtcgat ggatgatagg tcgaattgct
    15721 ttatctactt tcaccttttc acccttactc tgcatatact gttggtaagc caacaaaccg
    15781 attaacttgg atgccagctg ctcattgcac aaatatttgt atcctgtcaa gtaattcact
    15841 gattctttat agatgtccaa ctgattgtca gtgatactca ccatcacttc ttcatcctcg
    15901 ccggattgca ctttgaccgt ctttgcatcg gacagaatac ccaatgtgcc ctccgccaat
    15961 tcagttccct gtggcagtat cggaatcgta tattcctctc catcctgata gccatcgtcg
    16021 cgagtgaaaa gatagctgat ggtcacgcta tcggcatgaa ctgcctgcat cggcactgtt
    16081 tcatgaaatc cctccatgaa actcacttcc tgccgtttca acgtatccgt tccgacgcag
    16141 aactgtgtct ttccggctat gtgctgccca tccagataat tgcggatagt cccaaccacc
    16201 gtactctgat ccccctccac caggaagcgg ggagttttca actccgccat caacggtttg
    16261 taagagcgga tggaacgtcg gaaagtaccc gtctgcaaac gacggttcat gccataaacg
    16321 acagtttc
//
