LOCUS gnlProkkaKBHOMAJI_35 17416 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|KBHOMAJI_35. ACCESSION gnlProkkaKBHOMAJI_35 VERSION gnlProkkaKBHOMAJI_35 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 06:55:58 Original ID :: gnl|Prokka|KBHOMAJI_35 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 17416 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..17416 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[4560:7416]" /cutoff="20000" /detection_rule="cds(LANC_like and DUF4135)" /neighbourhood="10000" /product="lanthipeptide-class-ii" /protocluster_number="1" /tool="antismash" proto_core 4561..7416 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(LANC_like and DUF4135)" /neighbourhood="10000" /product="lanthipeptide-class-ii" /protocluster_number="1" cand_cluster 1..17416 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(LANC_like and DUF4135)" /kind="single" /product="lanthipeptide-class-ii" /protoclusters="1" /tool="antismash" region 1..17416 /candidate_cluster_numbers="1" /contig_edge="True" /product="lanthipeptide-class-ii" /region_number="1" /rules="cds(LANC_like and DUF4135)" /tool="antismash" CDS complement(3..1703) /gene_functions="transport (smcogs) SMCOG1243:ABC transporter, permease component (Score: 133.2; E-value: 2.1e-40)" /gene_kind="transport" /locus_tag="ctg35_1" /transl_table=11 /translation="MIWSITKSNIKKNFPLYRIYFLATIGLLSIFIAFLNFISDKIIAE KIGDSGQALVIANGSLLFLIVFLVVFLIYFNNFFVKKRSQDLGVLAILGFSKRELTKLL TLENLVILVLSYLVSLLLGPTLYFLAVLVITHLLDLTMEVQWFITVKEIIESLGILVVV FLINFITNGVIIAKQSLIEFVNFSKKAEKKIRIRKVRAIIAITALLLSYVLCLTTVFSS TRKMLLSVGMVPISLLIIILVILGSIFTIRYGLTFVISFLKEKKKRLYRPLSNIIYPKF NYRIATKNKLLTVLGGLLTLTVSVTGIMVMLYAYSLNGIERLTPSAIEYNVESENGQVN VTNILENGQVSLVDINLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRKNSI EGSESLPLLINYFPTEISLGKTFNLENAYDVTVKQVSTNNVFSFSTSVTTLVVSDKLYA ELSSRFPEKKMTIRTFNGDSIRSSETFYNQFSTVPDVISSYSRERTVKTANIATYIFIT FLSILFIICTGSILYFTSLIEIMENKEEYSYLSKLGYSKKMINRIVGYEI" CDS complement(1705..2442) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 198.2; E-value: 2.7e-60)" /gene_kind="transport" /locus_tag="ctg35_2" /transl_table=11 /translation="MKQLVLKDVCKKYPNQLNYALDHINLIVEKGEFVAVMGRSGSGKT TLLNVTSIIDKIDSGNIYCADKEISTFSDKEATNFRKNDIGFVFQDYMLLDSLTIRENI SVALSLKNVDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKDPEII FADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME IDKKDCGESFYDVISQALSDRGE" CDS complement(2439..4583) /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_C39" /gene_functions="transport (smcogs) SMCOG1288:ABC transporter related protein (Score: 195.1; E-value: 3.5e-59)" /gene_kind="transport" /locus_tag="ctg35_3" /sec_met_domain="Peptidase_C39 (E-value: 2.6e-24, bitscore: 75.5, seeds: 36, tool: rule-based-clusters)" /transl_table=11 /translation="MRKITPIEQTTPTECGLCCLYMMLDYFDISETYFKLKQQVNLGRN GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRNDVFTIVDPAV GKYVLAKNEFFELSPKFYTEFFYDKVTNSSKKIVKRGLVGRNVKEMIFVNRKDIFLTIL YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYFLKNISLVK LQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERIISIWLDII LMFASISYITYVSTPLGIILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL MDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFSIPILLILL FLYYXPNSGSGELILLYMMVLNFINPINNILNSIDEILYGVKHYERVLEISTLDNETNG TYKLSEDTDIEINLKNINYQYELNGAKVLNGINLKVHSGEFVAIIGKSGSGKTTLAKML LGYVSPSSGDITYNNISFSKIDKKDFRNISAFVSQDSPMFDGDVMYNISLGRESVSGEQ VIETCKRVSIYDDIRSMPMKFHTLLFRDNPSISGGQKQRISLARELVTTPRILVLDEPT SALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGNHYYLYKNN KYYCDLYDSYMNKYQEEEVK" CDS complement(4561..7416) /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: LANC_like" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: DUF4135" /gene_functions="biosynthetic-additional (smcogs) SMCOG1070:lanthionine synthetase C family protein (Score: 772.2; E-value: 1.4e-233)" /gene_kind="biosynthetic" /locus_tag="ctg35_4" /sec_met_domain="DUF4135 (E-value: 1.2e-83, bitscore: 271.2, seeds: 79, tool: rule-based-clusters)" /sec_met_domain="LANC_like (E-value: 2.4e-80, bitscore: 259.7, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MSNGKINMIKRDELKLDYQRHQFYEYFNSIFNYDILDASISENIY LLRKTTDKLFYIEFENQLFETVMFLSMKTLVLDINNFSKEIGNKSEAYEQYIQQIKEEN GINNFFDRYPYLLKQINREVRLIEESYSLLFDRFLKDLSELRSCFNITEPLSNVEFSLG DSHSQKQTVVKIEFKGKSIYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYC WQLGVDYINSNNDEVKRIYLKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQ RKLNVQTNNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNISGISGKGGKRKKGKYE LINKNRGDMKLVKTDYFQEDSYNIPTLNEKMVEPLDYANEVIAGFRECYTFLMTQCAKV KKILYGFPKLRTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILYESKHIEQFIV DSEIKDLMNGDIPYFSMDPNGNVYNSLGTVIGNLGKTTSLFDNIATLNDERMKFTCELI GIVLKKPIKHWERKDGKSYYFPSISSKQSSNEEILDSVRQIFIDANKDSFSSEEEMTWL NIDITETEQWVISPQNITLYNGLIGNALGYLYAYQILGEERYLVSLNKILKTLETTKNL IESSDMSVFLGKGGLIYLYFSLWKRLKLTQYQKLYLDIIKEFSSQSLEEQNIDYISGVS GLLVVLCNIYNVEQNKTVYHLINRVSEFIIDNVKKEDDKVYWVSDFSDSEVLNGLSHGQ SGIAYALLLSWEINKNLNYFKIAKSAIDFENTRXSDGNWIDFRNKGKRSELGMPDPIYW CHGATGIGLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNL DDSLKNEVDIEGIMLNIVRNSQKFGWESGLPQHTRMFNMMVGEIGIAYQLLRYISNYEV PSLLLLDVPKGSVESEKNYTD" CDS complement(7479..7613) /gene="allorf_07479_07613" /gene_functions="biosynthetic-additional (lanthipeptides) predicted lanthipeptide" /gene_kind="biosynthetic-additional" /locus_tag="allorf_07479_07613" /protein_id="allorf_07479_07613" /tool="antismash" /transl_table=1 /translation="MLSLNNAIEEVSEKELMEVAGGKRGSGWIATITDDCPNSVFVCC" CDS_motif complement(7548..7613) /prepeptide="leader" /note="peptide class: {self.peptide_class}" /note="predicted sequence: MLSLNNAIEEVSEKELMEVAGG" /locus_tag="allorf_07479_07613_lanthipeptide" /aSTool="lanthipeptides" /tool="antismash" CDS_motif complement(7479..7547) /prepeptide="core" /locus_tag="allorf_07479_07613_lanthipeptide" /peptide="lanthipeptide" /predicted_class="Class II" /score="4.40" /molecular_weight="2300.6" /monoisotopic_mass="2299.1" /core_sequence="KRGSGWIATITDDCPNSVFVCC" /aSTool="lanthipeptides" /tool="antismash" /leader_sequence="MLSLNNAIEEVSEKELMEVAGG" /leader_location="[7547:7613](-)" /alternative_weights="2318.6" CDS complement(8209..13731) /locus_tag="ctg35_5" /transl_table=11 /translation="MEEQKQNKTMTKAEKVQANLSAIKLVKALEADNRLADSDEQEILS NYVGWGGLANDFFDSKINRFAKERDELKSLVTKEEYRAMEMSSLTAYYTSPEIATAMWD KIVESGFKGGNILDPSMGTGIFFETMPEDIKKNSTLYGIELDTITGAIAKHLHQDATVL VQGFETVNFEGTPFDLVITNVPFADVRIVDKAYDNKPYRIHDYFFKKAIDLVPYHGMVA AITSTGTADKSAGSILPELRRSGTQFLGGVRLPNTAFKDAGTRVVTDILFFQKGAFIPV PDNNIDFWSSDRKKLPFDKRVSLNPYFFQDAICKNPCVLGDYQVRHFNGGTLDLVVDSS FDLASELQEALSKVTVPFEVERLEPRDIILKEEVNHLDQDLLTSLDIRLNEYACDKNGR VYYRDNTSIRPSSRAAEMIFYQDEQGQFVKYDDKYKEEAILDFETAVEADPNIVTNTWV SQTPSKAAKSKGLYKGIYFYETPLTDTENKRIRSMVAIKNAYQAIIDIQMMTDYDEGKF KQLLATLNQAYDTFKKKYGYINQAVNARLFDRDDRYPLIASLELEELDENDSSKVVFVK SDAFKKPTIRPKKHLHQVMSAVEALNVSLSEGCGVDLNLMSSVYPDVSEDMMISELGET VMIDVERYIDDKTVHYVTKDKFLSGDVLAKRDCINYLVEDGDTQADWERYLELILSVVP EPVVLSDIDFSIGSSWIPSNVVSQWVFNELLDEKVGLHSEEAKSLLVTSRIGRGFNERL LNCYMSRQSNLRLGLRDEYTKSYSHATDIVAHLLTSNQPTIMRNFGTTENPIRKVDEVA TANLRECERVLQESFKNFIHENPTVQEVIEDTYNEVFNRYVTRQYDGSLLEFDGLAKGV ELRPHQKNAVQRILEERRALLAHEVGTGKTLTMISAAFKMKELGLIHKPLFVVPSSLTA QFGQEIMRFYPTKKVFVTTEQDFEKSRRRLFVSRVLTSDYDGIVIGHSQFEKVRVSQER EQAFISEKIDELDEIIGYAKANDDKITFKQAQSMRRSLEANLETLLENKTGIDEFINFE SLGIDMLFVDEAHGYKNVRPMTRLGNVAGITNRTSKKNMDMEMKVRVLQEEHDTRHVVF ATGTPVSNSISEMYTMMNYLQPDVMEHFGVSFFDAWVGVFGIVENSLELNPTGDKYISR KRFAKFMNLPELMAIYRQTADIQMTEDLNLPVPMVEKVAVESQLTENQKVYLDELVERS DRVKNGSVDPSEDNMLKITSEARKLALDMRLLDAELYVRADADKLMQVVERVDKIYHVE AKHKGTQMIFSDLGTPNGKGFSVYQELKDLLVERGIPEEEIAFIHDAANKKAKLQLQRQ MNAGEIRILMASTEKGGTGLNVQRRMKAVHHLDVPWKPSDIIQRNGRLVRQGNIYRKVN IFHYITKGSFDNYLWQIQETKLRYITQIMTSRTPMRASEDIDEQTLSASEFKAIATGNP YLKLKMELDNEFELLSNRRKAWKRDIALSQKRIKQALKDKENYEKKLSLLVQDKELAEK TRPWKEAVEKEDGKKYEVEHNPFVMTFEPDGYEATKKDVAGNQLNYAMQMNVASDPLHM KMTTLAHYRGFVLRALEQKSPWQPERMLDLHIIGQNSYAVRLDFASGIGTIQRINNVID GMDKQAKLLQENIDRCADTIKRGEAADVFADQARLDYVSAKRAIVNPLIEVEDESKKPT VEQIEEAINAFESQYKADHPEMDEDSDVKVSSITEEYSASYDPDEESELVEVIDESVDE AEAAFEEEELVIQETVEETTRVVVSQEVLDMADDFLESISELFGMTEEHNNNVSTELVY ETSSVNEVVEAEVEVYEEISLFDFV" CDS complement(13805..14152) /locus_tag="ctg35_6" /transl_table=11 /translation="MKLTIIIYNNKRMIGKYLVDTVSETIETFVRKDDYLLNTEFTYER MVDFLKGRQIDFGRKNRKELLGYTYKAPDVWHEIAMTHGFDTDDFYWVSIPELNDEPFV LEDHHPNLGRR" CDS complement(14269..15816) /locus_tag="ctg35_7" /transl_table=11 /translation="MTKAENIQEIVDNRLKVPNGFFKWVKNDFPIYEWSNKSKTIISSD RKKFSEKVTKRLSLNSRLTFVGDTFYFVWMGVTKKRIEMQMYAVTQSFEEGKEKFDVSL YNFYQLANNKMVKAHWDPYLSAKKGKEIYSTGFQNQRNALFFGSGAFSVYTLYGGMENL IEKLQSKSELRYLDFDEVIKENFEISSVLPHLYKYRERIEFAQKIKARGIVKDLVGATF YRSYASYSLGHKHANMGKATMNFLRRNKQYLKNTDMNIEKAFFEEDMRRQYGRTFEGLY ELLINAMVPNRTPLIKCLNSILPSTVKPIRFINWMIKNEICLRDYEDYREMVEALGIPF DGDYVVIPKNWENKHTEIVENYSVLLENQLERGTHLRVTNAVTNLRAEKRRREEEKKEA KLRIVTAERLANMMKAQTTFDKYAFIFPKDESEIVREGKVLHHCVGRYAKEHFVYGSSI IVFVRDKTDRETPLYTLELKNNRIIQLRGERNKAADEEAKKEAEQFLAYCGKLEIQF" CDS complement(15876..16316) /locus_tag="ctg35_8" /transl_table=11 /translation="MTDTIKIDAFDRFMAVSHFDEEMAEAHTPTEDAIHNWIVDHQEDD ELIAGILKHLDRTIKDAMAYCIRKASKSDYREGQGAMVDDATVFSWVKEYFTAEKVETK PVVGKMTTGSKKSTKQPTKKTPEKDEKQLDLFSDLSIEEGEF" CDS complement(16332..17114) /locus_tag="ctg35_9" /transl_table=11 /translation="MIVNNILKEAIDNNIQDITFFPHGEDYEVAFRNSDVKQVHDFISS EDADALFGHIKFMADMDVTEKRCSQVRTCDYQLDDGRVITIRISTIVNFQGLETMSIRL IHVNERRISSSEFDSSCMEEVLEQVRIPGLHVITGPAGVGKTTLAYSLLSEAFKGGKVM TIERYVEIKDVSFCQLQVNEANGMELEKLVTFVLRFNPDVLFIGEANTQEEVEAVLKAI SAGLSVVTTVHKDGFSIPHDVLEMKQGKDGKRNVALIK" ORIGIN 1 cctatttcat atccgacaat ccgattaatc atttttttac tataacctaa cttactcaga 61 tagctatatt cttctttatt ttccatgatt tctatgaggc ttgtaaagta tagaatacta 121 cctgtacaaa taataaagag tatggatagg aaggttataa agatataagt cgcaatatta 181 gcagtcttta ctgtgcgttc cctactataa ctactgataa catcaggaac cgtactaaac 241 tgattgtaaa atgtttcgct tgacctaatt gaatctccat taaaagtcct aattgtcatt 301 tttttctctg gaaaacgaga actaagctca gcatataatt tatcagaaac caccagagtc 361 gtgacacttg tagaaaaact aaaaacatta ttcgttgata cttgttttac agtaacatcg 421 tatgcatttt ccaaattaaa ggttttccct aggctaattt ctgttggaaa ataatttatt 481 aacaatggta gtgactcact accttcaata gaattttttc ttccttgagc tttcattaac 541 tctttataat cactgtaatt aattatatca aaataaggaa ttgtttgccc agattctgtg 601 atagtcactt ctgggttagt gttcaatctc aataggttaa tatcaactaa actcacttgc 661 ccattctcta aaatatttgt aacattgact tgaccatttt ctgattcaac attatattct 721 atcgcagatg gagtcaatct ttctattcca ttaagagaat aagcataaag cattaccata 781 attccagtaa ctgaaacggt tagtgttaaa agccccccca agactgttaa taatttattt 841 tttgtcgcaa tacgatagtt aaatttagga tagataatat tagagagagg acgatataac 901 ctttttttct tttcttttaa gaaagaaatt acaaaagtca atccatatct gattgtaaaa 961 attgagccta aaataactaa gataattatc aaaagagaaa ttggtaccat ccctacgctt 1021 aatagcatct ttcgtgtgga tgaaaacact gtcgtcaaac ataaaacata tgacaatagc 1081 aatgcggtaa tagcaataat agctctgact tttcttatcc tgattttttt ctcagccttt 1141 tttgagaaat taacaaattc aatcaatgac tgtttagcaa taataactcc atttgtgatg 1201 aaattaatca gaaaaactac gactaatatt cctaaagact ctataatctc tttaactgta 1261 ataaaccact gaacttccat tgttaaatcc aatagatgag taattaccag tacagctaaa 1321 aaatataaag taggtcctag caataaactt accaagtaac tcagaactag aataacaaga 1381 ttttctaaag ttagtaattt tgttaattct ctttttgaaa accctaatat tgctaagact 1441 ccaaggtctt gactgcgttt ttttacaaag aaattattga agtagattaa gaataccacc 1501 aaaaatacaa tcaaaaataa caatgaacca ttagcgataa ctagagcttg accactatcc 1561 ccaatttttt ctgcgatgat tttatctgaa ataaaattta aaaaagctat aaaaatactt 1621 aataaaccga tcgtagctag aaaatagata cgatataacg gaaaattctt tttaatgtta 1681 gattttgtaa ttgaccaaat catattactc tcctctatcg gataaagctt gactaattac 1741 atcgtaaaac gactctccac aatctttttt atcaatctcc atgtgaagtt tcccatcttt 1801 gaggagtata actctgtcgg cataagaagc tgataaaaca tcatgagtaa ccattagaat 1861 agttaccttt tccgttttat tgatttcact caaaatcatc attgtttcct cagaagattt 1921 caggtcaagt gctcctgttg gttcgtcagc aaaaataatt tctgggtctt taatgattgc 1981 tctgataata ctgaccctct gtctttgacc tccagaaagt tgataagggt attttttcaa 2041 ctgctcatat aaattaaatc tttttgcata gctatttatc aaatcatcaa tctttgaaga 2101 atcaacattt tttagagaca aagcaacaga aatattctcc ctaatggtta gactgtctaa 2161 cagcatataa tcttgaaaaa caaaaccaat atcatttttt ctaaaattag ttgcctcctt 2221 atcagagaat gtgctaatct ctttatccgc acaataaata ttcccactat caattttatc 2281 aataattgaa gtaacattta aaagcgtcgt tttcccacta ccgctacgcc ccatgacagc 2341 tacaaattct cctttttcca caatcaaatt gatatggtct agagcataat tcagttgatt 2401 gggatatttt ttgcaaacat cttttaatac taattgtttc attttacctc ttcctcctga 2461 tatttattca tatacgagtc atataagtca caataatact tattattttt gtacaaataa 2521 taatggtttc catagtcaat aattttgcca ttatccatta ttaaaatctt atcagctttt 2581 tcaactgtat taagtctgtg agtaaccaaa accctcgtac aatgtaaagc ctcaacattt 2641 ttttggatta ttctttcagt ttttacatct aaagctgatg taggttcgtc aagaactaag 2701 attctagggg tggttacaag ttctcttgct aaagaaatcc gttgtttttg ccccccagat 2761 attgacggat tatctcgaaa aagtagagta tgaaacttca ttggcatact cctgatatca 2821 tcatatattg ataccctttt acaagtttca ataacctgtt ctcctgaaac agattctctc 2881 cctagcgaaa tattatacat cacatcccca tcaaacatgg gagaatcttg agatacaaaa 2941 gccgatatat tcctaaaatc ttttttatca attttagaga aggatatatt gttgtatgtg 3001 atgtctccac tactagggct tacatagcct aacaacatct tagctagagt tgtctttcca 3061 cttccacttt tccctataat tgcaacaaat tctcctgaat ggacttttag gtttattcca 3121 tttaacacct ttgccccatt taactcatat tgatagttta tattttttaa atttatctct 3181 atatctgtat cctctgataa cttataagta ccattcgtct cattatcaag agttgatatc 3241 tctaataccc tttcgtaatg cttaacacca tatagaatct catcaatcga attcaaaata 3301 ttattaatgg gattaataaa atttaaaacc atcatataaa gaagaataag ctcaccactg 3361 ccactatttg gtnaataata tagaaacaac agaattaaca aaataggtat ggaaaaagtt 3421 atcacataat ttactgctcc taaaagattg aaatatctat ttctatcata tgttgaattg 3481 atatagtcct taaaactttt atcccatttt gacaaaagtt ctttttcaga atttttagct 3541 ttaaaaagaa atagcccgtc catcagtgaa aagaatgttt gtaaagagtt cttttgtctt 3601 aaaacttctt tacctaactt ttcttgttta atgcttagtg acaggaaaaa aatcatcatt 3661 tctacaataa aaactatacc taatataatt cccaaaggtg tggaaacata tgtgatataa 3721 ctaatactcg caaacattaa gataatatcc aaccagatag aaataattct ttctgatagt 3781 aactccctca caatcatcaa accattatat ctatgaatga tgtctgtttt atctattttt 3841 ccaatatatt ctatgggaag tttcaataac ttagtcacaa acttttctga aatagtgctg 3901 tgaaatttat tttgcaattt cactaaagag atattcttta gaaaataaaa tcctccctga 3961 aaaaaaatta ttatagaaag taggacggca ctttctaaat agccaaactt tttaaggaaa 4021 acccaatttc catcaataat tccccttata aaaaatggaa ttgacactgt gataatctga 4081 aaaatcagag tatatagaat ggttaaaaaa atatccttcc tatttacaaa tatcatttcc 4141 tttacgtttc tgccaaccaa ccctcgtttg actatttttt ttgaagaatt agtcacctta 4201 tcataaaaaa attcggtata aaatttagga gacaattcaa aaaattcatt ctttgctaag 4261 acatatttcc caacagcagg gtcaacaata gtaaagacat cattacggat atcctctaaa 4321 attacaaaat gtgaatctga aacaaatacc atgacaggta agttttcggg atatttggaa 4381 aaacgataag tcttacatgt aactccgtag atagatgcaa tatctgatat attctttata 4441 ctcagtccat ttctccctaa attgacttgt tgtttcaatt taaaatatgt ttctgaaata 4501 tcaaaataat ccaacatcat atataaacaa cataatccac attcagttgg agttgtttgt 4561 tcaatcggtg taatttttct cactttcaac actccctttt ggaacatcta ataacaataa 4621 tgatggtact tcataattgg atatatatct aagcaactga tatgctatcc ctatttcacc 4681 aaccatcata ttaaacatcc ttgtgtgttg tggcaagcca gattcccaac caaatttttg 4741 agaattacga acaatattaa gcatgatacc ttctatatct acttcattct tcaaggagtc 4801 atctaaattc ataaataatt ccatattacc cattttcccg tgacaaaggc aatccgaatt 4861 caaataacca ttatttaata ccgtttgttt agccatttca taattatttt tcaactcttt 4921 atcgtttaac cattttgatt ctctatatct cgttaatccg atacctgttg caccatgaca 4981 ccaataaata ggatctggca ttcctaactc tgaacgtttt cctttatttc taaaatcaat 5041 ccaatttcca tcagaantac gggtattttc aaaatcaata gctgacttcg ctattttaaa 5101 ataatttaaa tttttattga tttcccatga taaaagtaac gcataagcaa ttccagattg 5161 tccgtgagat aatccattta gaacttctga atctgaaaaa tccgataccc aataaacctt 5221 atcatcttct tttttcacat tatcaataat aaattcagat accctattaa ttaaatgata 5281 tactgtttta ttttgctcta cgttatatat gttgcacaga acaactaata agcccgatac 5341 tccagaaata taatctatat tttgctcctc cagtgactgg ctggaaaatt ctttgattat 5401 atctaaatat aatttctggt attgagttaa tttaagtctt ttccacaaac taaagtatag 5461 ataaatcaaa cctccttttc ctaaaaagac tgacatatca ctactttcta taagattctt 5521 tgtggtttcc agtgttttca atatcttatt taatgagact agatatcgct cttcaccaag 5581 aatttgataa gcatataaat aacctaaggc attcccaatt aaaccattat acaaggtaat 5641 gttctgagga gatattaccc attgttcggt ctccgtaata tcaatattga gccatgtcat 5701 ctcctcctct gaagaaaaac tatccttatt tgcatcaata aatatctgtc taacgctgtc 5761 taagatttcc tcattagaac tttgttttga ggatatcgat ggaaaataat aagatttccc 5821 atctttcctc tcccaatgtt taatcggttt tttcaagact attccaatca attcacaagt 5881 gaacttcatt ctttcatcat tcagggtggc tatattatca aataacgagg ttgtctttcc 5941 tagatttcca attactgttc ctaaagaatt atatacattt ccattgggat ccattgaaaa 6001 gtaaggaata tcaccattca tcaagtcttt aatttcacta tcaacaataa attgttcaat 6061 atgttttgac tcatatagta tcgaaaatag attctccctc tttttttctg agaaaagata 6121 ttttggattc gtagaggctt gcaaaaattt tccatagtcg gaagtatttc tgaatatggc 6181 tctagttctc aatttcggga aaccatataa aatttttttg acctttgcac attgcgtcat 6241 gagaaatgta tagcattctc taaatcctgc aattacctca ttagcatagt cgagaggttc 6301 caccattttc tcatttaatg ttggaatatt atagctatct tcctgaaaat agtcagtttt 6361 cactaacttc atatccccac gatttttatt tatcagttca tacttcccct tttttctttt 6421 tccacctttt ccacttattc cagaaatgtt aggagcgctg tttttctcaa attgtacagg 6481 aaataaacca tttgaaagtg atgtctcata aattctctga taagtatcaa cagtaatccc 6541 ttcaaaatta ttagtttgta cattcaactt tctttgaaaa aatgtttcaa catcaattaa 6601 atataaatct ccgcctgaaa caatcacatt ttccatatgt aagtccgtaa tggaaaaaat 6661 ttcagaaaat gctgctaaaa caccatactt aaggtatatt ctctttactt catcattatt 6721 agaatttata taatccacac cgagttgcca acaataatcc gctttaatta agctttcagg 6781 aagactgaac gagggtatat tattagattt caataaacta ataagttcta acaaaatgtt 6841 gtatgaatca taacttttag gcttgtagta aatggatttc cctttaaatt caatcttaac 6901 aactgtttgt ttttgagaat gactatctcc aagtgaaaac tcaacattac ttaggggttc 6961 agtaatatta aaacacgacc ttaactcaga caagtctttt aaaaatctat caaatagtaa 7021 agaatatgat tcttctatta acctgacttc tctattgatt tgttttaaca aatacggata 7081 cctatcaaaa aaattattta ttccattttc ttcctttatt tgctgtatat attgctcata 7141 tgcctctgac ttatttccaa tttccttgga aaaattattt atatctaaaa ctagtgtttt 7201 cattgaaagg aacattacgg tttcaaataa ttgattttca aactcaatat aaaataactt 7261 atctgtcgtt ttcctcaata aataaatatt ttcactaata gaagcatcta gtatgtcgta 7321 attaaaaatt gagttaaagt attcgtaaaa ctgatgccgt tgataatcta gctttaattc 7381 gtctcttttt atcatattta tcttaccatt actcaaaaat cctgcttaga ctaagtctaa 7441 acaggatttt tttagtctac ttatcaagat tgttttaatt aacaacaaac gaatactgag 7501 tttggacagt catcagtaat agttgcaatc caacctgaac ctcttttacc accagctact 7561 tccataagtt ctttttcaga aacttcttcg atagcattgt tcaaagatag cattgttcaa 7621 aatatctttt gagtttttca tggcattcat tctcccttct gttagtatgt agtaaatatt 7681 ttctacgctc ttattgtaac caatacatct taatttttag tgagtaaaaa gtgcaaatat 7741 tattttttta ttaatatttt taaaatgtaa aatatcgctt tataaaaagc agtctctcaa 7801 atttcatttt ttgtagctat tttacaatcc aataccttct tattataaaa ttaatccctt 7861 aaattcagac taggtgactt aaaaaagaga aacactcaaa atagtgtttg tctactgtct 7921 aaattttcta gctcttattc ttgtttcttg tcgagaggtt tgagtatgaa aaaacaattt 7981 aacttataca tacttctttt tgaggtaatt attataatat tttcatcact acctttttta 8041 taaactttat tcaaaaggag tcattctgac tccttttgaa cataaagaaa atttctaacc 8101 aaatattgaa cagacggcta ttccaaatat ctgaaacatt tcaatttatg acaatcaata 8161 atagaaaagg ataacatctc ctcaagaaga tattatcctt ttttgtgatt aaacgaagtc 8221 aaatagtgag atttcttcgt agacttctac ttctgcttct actacctcat taacagagga 8281 ggtttcataa actaattctg tagatacatt gttattatgt tcttcagtca tgccaaagag 8341 ttcagaaata ctttctagga agtcatcagc catatcaaga acttcttgtg aaacaacaac 8401 acgagtcgtt tcttcaacgg tttcttgaat aactaattct tcttcctcga aggcagcttc 8461 tgcttcatct actgactcat cgataacttc aacaagttcg ctttcttcat caggatcata 8521 gctagcacta tattcctcag tgattgagct aacttttaca tcagagtcct catccatctc 8581 tggatgatct gccttgtact gtgattcgaa agcattgata gcttcttcaa tttgctctac 8641 agtaggcttc ttagactcgt cctcgacttc gataagagga ttaacaatgg cacgtttagc 8701 cgatacatag tcaagacgag cttggtctgc aaaaacatct gcagcttctc ctcgcttaat 8761 agtatctgca caacggtcaa tgttttcctg caagagtttg gcttgtttat ccataccatc 8821 aataacattg ttgatacgtt ggatcgtccc aataccactc gcaaaatcta gacgaacagc 8881 atagctattt tgaccaataa tatgcaagtc aagcatgcgt tctggttgcc aaggtgattt 8941 ttgttccaac gcacgaagga caaaaccacg ataatgagca agggttgtca ttttcatatg 9001 gagtggatca gaggcaacat tcatctgcat agcatagttc agttgattac ctgcaacatc 9061 tttcttagtt gcttcgtatc catctggttc aaatgtcata acaaatgggt tatgctcaac 9121 ctcatatttc ttaccatctt ctttttcaac cgcttctttc caaggtcttg tcttttctgc 9181 aagctcttta tcctggacta atagagaaag tttcttctcg taattttcct tatctttaag 9241 ggcttgctta atacgttttt gagacaaagc aatatcacgt ttccaagcct tacgacgatt 9301 agacaacaac tcaaattcgt tatcaagttc catcttaagt ttaagatatg gattgcctgt 9361 cgcaatggct ttaaattcag aagctgagag tgtttgctcg tcaatatcct ctgaagctcg 9421 catcggtgta cgactggtca tgatttgcgt aatataacgg agctttgttt cttgaatctg 9481 ccaaaggtag ttatcaaaac ttcctttagt gatatagtgg aaaatattta ccttacgata 9541 gatatttcct tgacgaacca agcgtccatt acgttggata atatcagacg gtttccaagg 9601 cacatcgaga tgatgaacag ctttcatacg acgttggacg ttaagaccgg ttcccccttt 9661 ttccgttgaa gccatgagaa tacgaatctc accagcattc atttgacgtt gaagttgaag 9721 cttagccttt ttgttagcag catcgtgaat aaaagcaatc tcttcttctg gaattcctcg 9781 ttcaacaagc aaatctttca actcttgata aacagagaaa cccttgccat taggagttcc 9841 aaggtcagag aaaatcattt gtgtcccttt atgcttagct tccacgtgat aaatcttatc 9901 cactcgctca accacttgca tgagtttatc tgcatcagct cttacataga gctctgcatc 9961 aagcaaacgc atatccaaag ccaactttct ggcttcacta gtgattttga gcatattatc 10021 ttcactagga tctacactcc catttttaac tcggtctgag cgttctacaa gctcatccaa 10081 ataaaccttt tggttctcag tcaactgact ttcaaccgct accttttcta ccataggaac 10141 tggaagatta aggtcttcag tcatttggat atctgcagtc tgacggtaaa tcgccatcag 10201 ctcagggaga ttcataaatt tagcaaagcg tttacgtgaa atatacttgt ctccagtagg 10261 attaagctcg agactattct caacaatccc aaatacacca acccaggcat caaagaaact 10321 tacaccgaaa tgttccataa catctggttg aagataattc atcatcgtat acatttcact 10381 gatagagttg gaaacaggcg taccagtcgc aaagacaacg tgacgtgtat catgctcttc 10441 ttgaagcacg cgcaccttca tttccatatc catattcttt tttgaggtac ggttggtaat 10501 accagcaacg ttccccaaac gtgtcatagg acggacattc ttgtacccgt gggcttcatc 10561 aacaaagagc atatcaatac caaggctttc aaagttgata aactcatcaa taccagtctt 10621 gttttcaagc aacgtttcta agtttgcctc aagacttcta cgcatcgatt gtgcttgctt 10681 aaaagtaatt ttgtcgtcat tggcttttgc gtaaccaatg atctcatcaa gctcatcaat 10741 cttttcagaa ataaaggctt gttcacgttc ttgtgagaca cgaactttct caaattgaga 10801 atgtccaatc acaataccat catagtcact ggttagaaca cgagagacga acaagcgacg 10861 gcgagacttt tcaaagtcct gctcagtcgt aacaaacact ttcttggtag ggtagaaacg 10921 cataatttct tgaccaaatt gtgctgttag actagatgga accacaaaca atggtttatg 10981 aataagccca agctctttca tcttgaaagc tgctgaaatc atggttagtg tcttaccagt 11041 acccacttcg tgagcaagca gtgcacgtct ctcttcaaga atacgttgta ccgcattctt 11101 ttggtgaggg cgaagctcta cacctttagc caacccgtca aattccaaga gacttccgtc 11161 atattgacgt gtcacatagc gattaaagac ttcattgtag gtatcttcaa tcacttcttg 11221 gactgttggg ttttcatgaa taaagttctt aaagctttct tgtagaacac gttcacactc 11281 acgtaggttt gctgtagcca cttcatcaac cttccgtatc gggttttcag tcgtaccaaa 11341 gttacgcatg attgttggtt gattacttgt aagcaaatga gccacaatat ctgttgcgtg 11401 tgagtagctt ttagtgtact catcacgtag acctaaacga aggttagatt gacgactcat 11461 atagcagttt aacaagcgtt cgttgaaacc tcgtccgatt ctggatgtca ctaatagtga 11521 tttagcttct tcagaatgga gaccaacctt ttcatccaac aattcattaa acacccattg 11581 agaaacgacg ttactaggaa tccagctaga accaatgctg aaatcaatat cagataagac 11641 aacaggttct ggtacaacag ataaaatcaa ttccaaataa cgttcccaat ccgcttgtgt 11701 atctccgtct tcaacgagat agttaatgca atcacgttta gcaagaacat cacctgaaag 11761 gaatttatcc ttagtaacat agtgtacagt cttatcatca atatagcgtt ccacatcaat 11821 catcacggtc tcacctagtt cagaaatcat catatcttct gaaacatctg gatagacaga 11881 actcatgagg ttcaaatcaa cgccacaacc ttctgaaagc gacacattca aggcttctac 11941 tgctgacatc acttgatgga ggtgtttttt aggacgaata gttggctttt taaaagcatc 12001 tgacttcaca aaaactacct ttgagctgtc attctcgtcc aactcctcta attcaagact 12061 agcgataagc ggataacgat catctcggtc aaagaggcga gcattcaccg cttgattgat 12121 ataaccatac ttcttcttga aagtatcgta ggcttgatta agtgttgcaa gcagttgttt 12181 gaatttccct tcatcatagt ctgtcatcat ttgaatatca ataatggctt gatacgcatt 12241 tttgatagca accatgctac ggatacgctt gttttctgta tccgtaaggg gtgtttcata 12301 gaaataaata cctttgtaaa gccctttact tttagctgct ttagaaggtg tttgacttac 12361 ccatgtattc gtaacaatat tagggtctgc ttctactgct gtttcaaagt ctaaaatggc 12421 ttcttctttg tatttatcat catattttac gaactgtcct tgttcgtctt gataaaaaat 12481 catttcagct gcacgtgagc taggacgaat agacgtgtta tcacgataat agacacgccc 12541 atttttatca caagcatact cgttcaatcg aatgtcaagt gaagtaagta agtcttggtc 12601 aagatgattc acttcttctt taaggataat atcacgaggt tctagtctct ctacttcgaa 12661 aggcactgtt acttttgata gtgcttcttg aagctctgaa gctaagtcaa aagagctatc 12721 taccacaaga tccagtgttc caccattgaa atgacgtacc tgataatcac ctagaacaca 12781 aggattttta caaatagcat cctggaagaa atagggattg agtgagacac gtttatcaaa 12841 ggggagtttc tttctatctg aggaccaaaa gtcgatatta ttatcgggaa cagggataaa 12901 ggctcctttt tggaaaaaga ggatatctgt taccactcgt gttccagcat ctttaaaagc 12961 agtatttggt aaacggacac cacctaaaaa ctgagttccg ctacgacgga gttctggcag 13021 aattgaacca gcactcttat ctgcagtacc agttgaagtg atagcagcaa ccatcccatg 13081 atagggtacc aaatcgatag ctttcttaaa gaagtaatca tgaatacgat aaggtttatt 13141 atcataagcc ttatcgacaa tgcgaacatc cgcaaatgga acattcgtaa tgaccaagtc 13201 aaatggggtc ccttcaaagt ttactgtttc aaatccttgg actaaaacag tagcatcttg 13261 atgaaggtgt ttagcaatag caccagtaat ggtatcaagt tcaattccat aaagagtaga 13321 attcttcttg atatcctctg gcattgtttc aaagaagata ccagtaccca ttgatggatc 13381 aagaatatta cctcctttaa aaccactttc tacaatctta tcccacattg cagtagcaat 13441 ctctggactt gtgtagtaag ccgtcaagga gctcatttcc atcgcacgat attcttcttt 13501 agtgacaaga ctttttagct catcacgttc ttttgcaaaa cgattaatct tactatcaaa 13561 gaaatcgtta gcaagtcctc cccaaccaac atagttagaa agaatttctt gttcgtcact 13621 gtcagctaga cggttatctg cttcgagtgc tttcacaagt ttaatggcag aaaggttagc 13681 ttgaaccttt tctgctttag tcattgtttt attttgtttt tgttcttcca ttgttgtttt 13741 tctccttaaa actaaaaaag acctggtaca ataccaagtc tttctttttc gttaaaataa 13801 ttgtttatcg tcttcctaag ttaggatgat ggtcttctaa aacaaacggt tcatcgttga 13861 gttctggtat tgatacccaa taaaaatcat cggtatcaaa accgtgtgtc atggcaattt 13921 catgccagac atctggagct ttataagtat agcctaaaag ctcttttcga ttttttcgac 13981 caaaatcaat ttgacgccct tttagaaagt ctaccatacg ttcataagtg aattctgtat 14041 ttaacagata atcatctttt cttacaaacg tttctatagt ctcactaacc gtatcaacta 14101 ggtatttccc aatcatcctt ttgttgttat atataataat agtcaatttc ataactattg 14161 tcctcccagc attttactag agaatacatc taatgttttc tttagtatag cacagaaaat 14221 tcgagattga ctaataacct attgacgatt ctatttttct cctcttatct aaaactgaat 14281 ttcaagcttt ccacaatagg ctaaaaattg ttctgcttct ttcttagcct cttcatctgc 14341 agccttgttc cgttctcctc tcagttgaat aatcctatta tttttcaatt ctagggtata 14401 aagaggagtt tctctgtcag ttttatcacg tacaaagaca ataatagagg aaccgtagac 14461 aaagtgttcc tttgcatacc ttccaacaca gtgatgtagg actttgcctt ctctgacaat 14521 ttcactttca tctttaggaa agataaaggc atacttgtca aatgttgtct gagccttcat 14581 catgtttgcc aagcgttcag ctgttacaat tctcaacttc gcctctttct tttcttcctc 14641 acgtcgcctt ttctccgctc tcaaattagt tacggcatta gttacacgta aatgagtccc 14701 acgttctagt tgattctcga gaagaaccga ataattttcg acaatctctg tatgtttgtt 14761 ttcccaattt ttaggtataa ctacataatc tccatcaaat ggaattccca gagcttctac 14821 catttctcga tagtcctcat aatcacgaag acagatctca ttttttatca tccagttaat 14881 gaaacgaatt ggtttcaccg tggatggtaa gatactattt aaacacttaa ttagtggcgt 14941 cctgttagga accatagcat ttataagtaa ctcgtataaa ccctcgaagg ttcgaccata 15001 ttgtctacgc atatcttcct cgaaaaatgc cttttcgata ttcatatccg tattttttag 15061 atactgttta ttccttctga gaaaattcat ggtagcctta cccatatttg catgcttgtg 15121 tccaaggcta taagaggcat aagatctata aaacgtagcc cctaccaaat ctttgacgat 15181 tccacgcgcc ttgatttttt gagcaaattc aatacgttct cgatatttat aaagatgagg 15241 tagcactgag cttatctcga aattttcttt aatcacttca tcaaaatcta agtatctcaa 15301 ctcagatttt gattgtaact tttcaataag attttccata ccaccataaa gcgtatagac 15361 actaaatgca ccagaaccga aaaagagagc atttctctga ttttggaatc cagtactata 15421 gatttcttta ccttttttag ctgaaagata tggatcccag tgtgctttta ccatcttatt 15481 gttggcaagc tgataaaagt tataaaggct gacgtcaaac ttttcttttc cttcttcaaa 15541 tgattgagtc actgcataca tttgcatttc aatgcgtttc tttgtgactc ccatccagac 15601 aaagtaaaaa gtatctccta caaaggttaa acggctgtta agtgataagc gttttgtaac 15661 cttttccgag aatttttttc ggtcggaaga gataattgtc ttagacttat ttgaccattc 15721 atagatagga aaatcattct tcacccattt gaaaaatccg ttaggaactt ttaaacgatt 15781 atctacgatt tcttgaatat tctctgcttt tgtcattgtt ttttctcctt aattaataaa 15841 aaatggccct aggaccattt ttctatttat tgttgttaaa attcgccttc ttcaatagat 15901 aaatccgaaa aaagatctaa ctgtttctca tccttttcag gagttttctt agttggttgc 15961 ttggttgatt tcttactacc agtagtcatt ttacctacaa ctggtttagt ctcaaccttt 16021 tcagcggtaa aatactcttt aacccaagaa aagactgtgg catcatcaac catagcaccc 16081 tgaccctctc tatagtcaga tttactggct tttctgatgc agtaagccat agcatcctta 16141 atcgtacgat caagatgttt aagaatccca gcaatcagct catcatcctc ttgatgatca 16201 actatccaat tatgaatagc atcctcagtc ggtgtatgtg cttcagccat ttcttcatca 16261 aaatggctta ctgccatgaa gcggtcaaaa gcatcaatct taattgtatc agtcattgtt 16321 tttctcctct tttatttaat caaagctaca tttcgtttcc catcttttcc ttgtttcatt 16381 tctaaaacat catgtgggat tgaaaagcca tctttatgaa ctgttgtaac gacacttaat 16441 cctgcagaaa tagccttaag tactgcttct acttcttctt gtgtattagc ttcaccaata 16501 aacaagacgt cagggttgaa gcgtaataca aaagtcacga gcttttccag ttccataccg 16561 ttagcctcat tgacttgtag ctggcaaaaa gatacatctt ttatttcgac atatctttca 16621 attgtcatta cttttcctcc tttaaaagcc tcagaaagta acgagtaggc taaagtcgtt 16681 ttgccaacac ctgcaggacc agtaatgacg tgcaagcctg gaatgcgtac ttgttcaagc 16741 acttcttcca tacaactact atcaaactca ctcgaagata ttcttcgctc attcacatga 16801 ataagtcgga tagacatcgt ttctaatcct tgaaaattaa ctatcgtcga tatcctaatg 16861 gttatgactc taccatcgtc caactgatag tcacaagttc ttacctgact acaacgtttt 16921 tcggttacgt ccatatcagc cataaattta atatgaccaa atagagcatc cgcatcttct 16981 gatgaaatga agtcatggac ctgtttaaca tcagaatttc taaatgctac ctcgtaatct 17041 tcaccatgtg ggaagaaggt aatatcttgg atattattat cgatagcttc ttttaaaata 17101 ttgtttacaa tcattgtttt tctccttttt cagtttctaa taacagcttt aactctgcag 17161 cttctttctg caattcacga atcgtactca acaactcgta acgtttggaa agaaccttat 17221 ctctatcaag aattgtagtt ttattgataa ggtcaacctt atcaatttta tacagtttac 17281 agagcatcga aaattgcggt tctttaggaa tagaccgtcc tttttcataa ttattgacag 17341 ttcccttaaa aaccccaatt ctatttgcaa cgtcctgtag agatagaggt ctatttaatt 17401 ctttcctagc tgtttc //