LOCUS       gnlProkkaMGBCDAAK_30   16752 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MGBCDAAK_30.
ACCESSION   gnlProkkaMGBCDAAK_30
VERSION     gnlProkkaMGBCDAAK_30
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 07:16:08
            Original ID  :: gnl|Prokka|MGBCDAAK_30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16752
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16752
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6046:6752]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6047..6752
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16752
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16752
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(149..493)
                     /locus_tag="ctg30_1"
                     /transl_table=11
                     /translation="MISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLYRKSVNWLSV
                     VMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAIFYFIKALEK
                     RHVFDRMRLR"
     CDS             complement(892..1026)
                     /locus_tag="ctg30_2"
                     /transl_table=11
                     /translation="MIKSILKFCLAATLIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             complement(1043..1288)
                     /locus_tag="ctg30_3"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             1574..3088
                     /locus_tag="ctg30_4"
                     /transl_table=11
                     /translation="MLAFKLCKSFLVIYVKRAIKMTEKLTTETGQPWANNEHSQTAGAR
                     GPVLMQDYNLLEKLAHFDRERIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKK
                     TPVILRFSQVAGEKGYPDTVRDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFI
                     HSQKRDPKTNRRTQNMQWDFWAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVN
                     QNGEQFWVKYHFISDQGVKNMTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQI
                     LPYEEGLNYKWDIFDVTKVISHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPG
                     IEPSPDKLLQGRLFSYKDAQRYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVN
                     YEPNALHGPEEVPDAALSPDSVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINT
                     IKDALGQVTLPGVKKLEIKQFYEADKNYGTRVANALGMNIADIISD"
     CDS             complement(3246..3683)
                     /locus_tag="ctg30_5"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(4039..4782)
                     /locus_tag="ctg30_6"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(4775..6037)
                     /locus_tag="ctg30_7"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(6047..6175)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_8"
                     /sec_met_domain="TIGR04223 (E-value: 1.9e-08, bitscore:
                     25.3, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             complement(6156..6752)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_9"
                     /sec_met_domain="AgrB (E-value: 1.6e-35, bitscore: 113.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IETGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(7120..9234)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     962; E-value: 4.5e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEATKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(9625..9858)
                     /locus_tag="ctg30_11"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(10495..10851)
                     /locus_tag="ctg30_12"
                     /transl_table=11
                     /translation="MLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRVPTI
                     FDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQLAG
                     TKTIEDVKRAKLLR"
     CDS             complement(10864..11595)
                     /locus_tag="ctg30_13"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWNFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIIEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQ"
     CDS             complement(11622..13376)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 471.4;
                     E-value: 6.8e-143)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_14"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.9e-41, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-32, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDH
                     LKYIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVG
                     QSATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVII
                     PDDLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQ
                     EVIAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNF
                     PFARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAA
                     QRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLN
                     KQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPV
                     INVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQ
                     KVTQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPA
                     LSQLLNEL"
     CDS             complement(13458..13883)
                     /locus_tag="ctg30_15"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             complement(14056..15867)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 494.2;
                     E-value: 8.6e-150)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_16"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-44, bitscore:
                     142.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-38, bitscore:
                     123.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLTPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSATSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
     CDS             complement(16238..16624)
                     /locus_tag="ctg30_17"
                     /transl_table=11
                     /translation="MYCMMTKERIIFSTKVLEIGAESADFKSIGMAVLFGDEAPDALRP
                     SCFIIEVVPISEQITAGMKLEVDNQVYQITAVGGEVQTNLGRLGHTAISFTGAKEAKLP
                     GTLYVEQGDYPDFKVGSVVRIIAE"
ORIGIN
        1 taaattaaat ttagtcatag taaaaccccc gagattgttg tccaatctcg ggggttcact
       61 tcagcaatag aaaagttaga cttatttgtt taacgattgt agcgcgtttc ataccgtgtt
      121 caacctcttt ttgtagcatc catcgatatt atctaagcct cattctatca aaaacgtgtc
      181 gtttttctaa cgccttaatg aagtaaaaaa tagcaatcac ctgtaatggt atctgaatga
      241 tgacgcgtgc caatcttccc aacaataaca ctttaaaatt agtgccaaat agcactgaaa
      301 ttagccatga gtccatcatc aaactaacaa aaatcattac aagtatttgc gtcatcacaa
      361 cggataacca attgactgat ttacgatata aaaacaaacc gtcaataaat ccccctaaaa
      421 atgcagttaa caaaaaggca atctgaaacg cgccggaacc aaaaatagta aagcttaata
      481 tatcggagat catctccaag agaccacccc aaatgggacc atatagataa ccaatacaag
      541 ccatagacaa aaagccaaaa gataattgaa aatacgctgg tccgatagca attttgtata
      601 aaataacgtc taaggccaat aagaaagccg atgtagtcag cactaataaa ttcatttttg
      661 gcaactgaaa aacatttttc gcaataagtt tagacatagg ccaatcctct ttttttgatt
      721 ttaatcatac cctcattctt aataaaagta aatattactt ttattcgatt gaaggtagtt
      781 taaaatcgtc gctcttgatt tagttccttg aactcaatga tattactcat actaaaagcc
      841 actaacaggt caactagtac acccatcagt ggctcattgt aaaattaatt tttatccatg
      901 taacttatct tgtaatttat cacccaagtt atcaattccc ttagcagtaa gtacggtccc
      961 accaataaga acaccactta cgattaaggt tgcagctaaa caaaacttta aaatgctttt
     1021 aatcatcgca atcatctcct tactaatcca tccgtgtcag aacaaatgag gttatcgcaa
     1081 caacaatcac accaccaata attgaaggaa caattgccat tccggctaat tgtggtcccc
     1141 atgatcccaa aagagcttcc ccaattgcag atccaaccaa tccggcaata atattactaa
     1201 tccaccccat cgatttacct ttattagtaa tagcacctgc aattgcacca ataatagcac
     1261 caatgatcaa aacccataac caatgcataa aatccctcct agacttatta aaccgcttaa
     1321 atacaataat agaattacac gaatatttaa gccgattcat aaatgattac ttcttataat
     1381 tatcatttta caattatcga taatgataga caaatataac acattattta ataaatgggt
     1441 cgctactatt tctcatgtga cgattccggg tggcctagaa aatatcaaac agcttgatag
     1501 ctgattaaaa ttaaactacg ccacatgaac gattaactta actgtgcata atgattgaag
     1561 tcactctgtt aaggtgttag cgtttaaatt gtgcaagagc tttcttgtaa tttacgtgaa
     1621 aagggcgatt aaaatgacgg aaaaattaac gacggaaacc ggccaaccat gggctaacaa
     1681 tgaacattcc caaacggcag gagctcgtgg tcccgtatta atgcaagact ataatctttt
     1741 ggaaaaacta gcccattttg atcgtgaacg aattccagaa cgggtcgttc atgctaaggg
     1801 ggccggagca aaaggttttt ttgaacttga aaacgacatg ggggaatata ctaaggcaga
     1861 cttatttaat ggtgtcggta agaaaactcc cgtaatctta aggttctcac aagttgccgg
     1921 tgaaaaaggt tatcctgaca ccgttcgaga cgtgcgcggt tttgccttaa aattttatac
     1981 tcagcaaggc aattatgatc tcgttggaaa caacacaccg gtcttttttg taaacgaccc
     2041 tttaaaattt cctgacttca tccattcaca aaaacgggat cctaaaacga accgtcgtac
     2101 gcaaaatatg caatgggatt tttgggctca ttctccagaa tcattgcacc aggtcactta
     2161 tttaatgggc gaccgaggtc ttcctgcgtc ctatcgaacc atgaatggtt acggttccca
     2221 tacttttaaa tgggttaatc agaatggcga acagttttgg gttaagtatc acttcatctc
     2281 agaccaaggc gttaaaaata tgactgctca agcagctgaa aaagcaatga gccaagattt
     2341 agattactta caagatgact tatatgatgc aattcaagaa aaaaattacc catcatggac
     2401 gatgtatgtc caaatcttgc catatgagga aggtctaaac tataaatggg acatttttga
     2461 tgtcactaaa gtcatctccc acaaagacta tccactaatt aaagtcggca aactaacttt
     2521 aaatgagaat cccactaata actttaccga tattgaagag gcggccatgt cgccagcaaa
     2581 ttttgttcct ggtatcgaac catctcccga caaattacta caaggtcgcc tattctccta
     2641 taaagatgca cagcgatatc ggttaggtgc caactttgaa gatttacccg tgaacaagcc
     2701 ggttgttcca gttcataatt atgaacgtga tggttacatg aaaattaata atcaaggtgc
     2761 tgaggtcaac tacgagccta atgcactgca tgggccagaa gaggtgccgg atgccgcact
     2821 ttcacctgat tctgttcgtg gtgaaacacg cgcacagcct tatcgctatc aagttgatta
     2881 cacaactcaa gcaggcgacc tatatcgctt aatgtcagaa cccgagcaag aacgcttaat
     2941 taatactatc aaagatgcgt taggccaagt tactttgcct ggtgtcaaaa aactcgaaat
     3001 caagcaattt tatgaggccg acaaaaacta cggtacacgc gtggctaatg ctctgggaat
     3061 gaatattgct gatattatca gtgattaata ttttgaccgg atgttatcca gcgcgatatt
     3121 atttttgtta taaagaatga tgatgccgtc tcatggttat taactaaaga gcgacaggtt
     3181 agactcatat cgtgtaagtc tagcttgtcg ctctttaatt aacaaaaaat cttagatata
     3241 gcttactact cgaccatcct tttattaata atgtgatccc ctgtattacc atctagacga
     3301 ctcaacaatg cattgaactt tagtcgccga actggtcgtg gaataaattg gcgaatatca
     3361 tcttcattaa agccaacttg aattttacta tcactaatga tgataggccg acgtaacaac
     3421 ttcggatgat cacacaacaa tttaagtgcc tcattcaatg gcatttcggg taacttaggc
     3481 gcaatttcag gatagtcttt agatcgagct gagataatat cgtctacacc atgttcggtt
     3541 aaactcaaaa tacgttttag atcttgcacc gtgggcgaat caacactaaa atttttctcc
     3601 ttgaactcaa tcccatgtgc ttccaaccat tgccgtgcaa ctctagaaga atgacagctt
     3661 gattgtgtat ataacctaat cattcctaat ctgcccctct ctcgttaaaa ttcatcacag
     3721 cgtattgatc gacattaact tctgcctgtc acaacatcct ttaaactaaa cgcattcgtt
     3781 actgtcatga ccaatccaat accccgtgaa cacatcttta ttataggctc tgaacaaggg
     3841 acataccgac cgttttaaga cgaataatct gaggataatc gttttaagta cacttttaaa
     3901 cggtttagga aagaacgaac ccagtacacg taatgctaac aaatatcact gcaatttcta
     3961 atcgaataac gctgaatttt catcgcgtag cacataaaaa gtcgcctact aatttaacag
     4021 gcgacttcct tggaactatt atgacttttt agcaagccat ttagctagat aacgattagc
     4081 ttgtgcagaa caaagcactt tttcaccatt tgtcatggtt aatcgtcgca agtgcttgtc
     4141 caatgactta atgcgtttca agttaacaac atatgactta tgacacctat agaaattagg
     4201 actcaaatca ggaacgtcct ttaacagtcc atagtattct aattcaccat catccaaatg
     4261 gactacgatt ttatggggac tggttgaact ttcaaaaaat ataatgcttt taacattaat
     4321 tgatctgacc gtctcaccaa tttttatttg aacatagtcg tcttggtcat tttcatcggt
     4381 ttgaaaacga tcttgcgcca cgtgtaaaac cttgctaaat cgctcataca aggaatctgg
     4441 aaaatcctta agaataaaat ctaatgcctc aacttgatat tgaaacacca tcaaagataa
     4501 ctccgtgtgt gtcgtgataa aaataatctt gctgcgacgg cccatgtcac gaatctggct
     4561 agctagttga ataccattaa tatctgaatt aagggcaata tctaacacat agattgcctt
     4621 ttgaggctgc tgtgcattaa ccttgtctaa caattcgtgg ggatcttggc atgctaaaca
     4681 gatactcatg tctagctgtt gatcgacgat taccttagta atgatttgcc gtatttgttg
     4741 taattgtttc ggatcatctt cgcaaatgta gacactaatc attctgagat actcgcttca
     4801 ccgtcaagcg ttgtaagaat accgctccta agactctggt ttcgagtatc atgttctcat
     4861 tgcgattaac aatcttactt aaactattca atccaatccc ccgattcttg cccttagtgg
     4921 aataacctgc ctctttcagc ttccataagg gtggtaactg ttcaaaaaca ttgttttgaa
     4981 tcaagaacac cgtactattt ttttcgataa aaatggcact cataatctct ccatcagcat
     5041 gtcctaccga tgcttcgatt gcattatcca acataatccc taatgcaatg tctaaatcca
     5101 attcattaac agtaatgtca attaatggtt cctttaaatc aaaatgaact tcaatctctt
     5161 gcgattgtgc atagctcaac ttactaaata ggatactctt aatcgacttc actttgaccc
     5221 gactcaaatc ttcaagatta tatttttctt ttaacacccg atttgaaacc ggtgcaagat
     5281 tcttttgata atattcttgt aaaccttcta aatcatcagt tttcaaatat tcatctatcg
     5341 aaatcaacat attctgatag tcatgtctga aacgtcgcaa ctcattatag tgagcttcga
     5401 tttcattcat atagcgagta tcattttgta tttgtattct ttgcttttgg acttcatatt
     5461 tggctcttac attttttaaa tattcgttat aaatcaccaa tactaacccc attacaactg
     5521 acaatataat taaattactt aatataacct ggaactgatt ttccagacct tcactcaaca
     5581 taatatacaa gtatattatc attaataata gtgcggttat gcgatttaag ctctgattac
     5641 taaacgtggg actgaaattc gtgcgatcca ttacaatatt aagaaaaatt aagcttacga
     5701 cactcaatat gacaaacact accacatacc cattaggaac tttcattaaa cgagttaata
     5761 tatcacaaat atggtcaacc ataatcgacc atatgaacac ttgaaatgtt atacatagtg
     5821 caccgcttag aactcgtaca taccaccaag tgaaaaatat aaacatcatt aacattaaaa
     5881 aagaaaaact aattcctaac tttgctaaaa aaatataact catcagcata cagacggata
     5941 agaatataac atcaaaaagt ctcacaaaaa atatatttct caacaaagat ttaattatca
     6001 aatagataga taattcttgg aagacaatca ttaacatata tctacactaa tccttgcttt
     6061 ttaattcatc aggaatttta gtttcgaata atatcccatg gcagcacata accaactgtt
     6121 tagtacctac gtattgaaaa agatggctaa gtactttata cattttttct ttcataattt
     6181 tccctccttt catagggcat tagtaataaa gcggctaatg ccatcgcaat taaaatgatt
     6241 gtgccaaaat aattattact aactatttgt aacaaactca aaattaatga caatccaatt
     6301 gcccgtcgct ttaatttttt tctcaatgac ttcgatgtaa taggattctt taccgtatca
     6361 gctggagcaa aaatacttat gattattaca aatattaaac ttaataacaa tctgtatact
     6421 tcagaaatac cagtttcaat cacatacggc acacccacaa acacaaagat agttaatatc
     6481 gtacataaca aatccgattt caagtgacgt ccataggcaa agccacgcaa aactaaaaaa
     6541 ctacccataa aaactaacac tgggaccaac tcgtgtagca gcaacgctaa gataatagta
     6601 attatcagct taggaataac atttaataca gtatcaatgc ctagtttaac tagtaatgcc
     6661 tgccgtcttt ctagttgaag attcttttga atcgcagcga ataaccgatc gcttaattta
     6721 taaagcaata gtttttgttc tggcttttcc atatcccact cctataatgc tcaaatacat
     6781 acctgtatca acagtttaaa acagtattaa ttaattgaaa agaatacata aatatattaa
     6841 ttattcaata ttgttttaag actagaaata aacatttaaa gatacatcag tttaattatt
     6901 catacgaaac taaagtttca tgtaaaaaga tcgttaatat aaatcagttt catcgatact
     6961 cccccttaat ttttccttag attacaagtc aaactagact taatttcact aattcacatt
     7021 actcaataga ttaatatcaa atggtgaaaa tcaacgaaaa gaggagatct atcaagcaat
     7081 ctcctcttac ataaagttat ttatgaacac tgatttaagc taagctgccg atatcacaat
     7141 ctcagcatcc actaaatcag ccttcaagtt tttgacatct aagtggtcaa ggtagaaatc
     7201 cgttaccttg tcacgaattt gttgttcaat tactcgccgt aatggccgcg cacccatcgc
     7261 ttcatcatag ccttgttcca tcagccaatc tttggccgct ttagttacct caagtttgat
     7321 ggattttttg gctaacgttt tttgtacatc cgccaacatc aaatcgacaa tttgacttaa
     7381 gtcttgctta gtcagatgtg aaaattccac gattccatta aaacggttca gaaattctgg
     7441 gcggaaaaat ggtgctaact tatccattaa tgactgatct cgttgcttgt caccacttaa
     7501 tgcttcatta ccaaagccag cattagaagt agcgataata atcgtatttt tgaaattaat
     7561 gacattgcct tgtccatccg ttaagcgccc atcatccatc acttgtaaca gtaacgttaa
     7621 tacttgtgga tcagcctttt caatttcatc taataataca atggaatatg gattacgccg
     7681 aacccgttcg gttagagtat tagcattatc ttcatagcct acgtatccag ccgaggtacc
     7741 aattaatttc gacacagctg tacgatcagc atattcactc atatctagcc gaataatcgc
     7801 atttttattt ccaaacatat ctaaggctaa ttgcttagct aattcagtct ttcctacgcc
     7861 agttgggccc acaaacagaa aacttccaat tggctgatca ccctctgaaa agcccgcacg
     7921 gttacgccga attgccttcg ctaccatttc aaccgcttca tcttgaccga ttaccttact
     7981 tttcagacgc ttatcaagat ttttcaagtg ctcaatatca ttagcgccca tatcagcaac
     8041 tggtatacca gttaaacgtt caaccgattg tgccacatca tcaatcgtgg cagtgatttt
     8101 ttctttttga tccgtttttt taattttttg cttggtttcc tcgatcgact tcttgatatc
     8161 agcggctttt gtaaagtcct ccgatttaac ggcggcctcc ttagttgcct ctaatttttt
     8221 aacgcgttga tccaatgtct caacatcagt ttgcgaattt ttagccgcta aatgagccgc
     8281 agtcatgtcg atcaaatcga tagctttatc tggcaaagtg cgttgtggta tatattggat
     8341 tgaataatcc acagccgcct tcaaaacatc atctggtaat acaacatgat gatgcttttc
     8401 gtacagcttt ttaacacctt gtaatatacg taaagtgtca gcggccgtcg gttcattaat
     8461 cacaacatca ttgaatcgcc gtgccaaagc cgcatttttc aaaatagtat tgcgatattc
     8521 atcttgagtc gtagccccga ttacagtcag ctcgccacgt gacaaagcag gtttaatgat
     8581 atcagccaat cctttgccac catcttcacc accagtggcg cccgtgccga taatctgatg
     8641 aatttcatcg aagaatagaa taatattacc agctgcttta acttccttta ctagctgttt
     8701 aatattttct tcaaaagaac cgcgatattg agttcctgct tccaaagacg ataaatcaat
     8761 cgaatagatt tctttatctt gaatcgtttc tggaacttta ccagccacaa ttgcttgtgc
     8821 cagaccttcg acgactgcag ttttacctac accagcatca ccaactaaga ttggattatt
     8881 tttcgtccta cgactcaaaa tttctgcagt ttcttgaatc tcattctcac gtccaatcac
     8941 tggatctagt aatccatcac gagcctgttc cgtcaaatta gtccctaact tttctaaaat
     9001 cccccctttt ttaacagcct gtttaccatc tttagatact tctattgttt tattattttg
     9061 gggtagctta ccagttgctc ggtattgagc aaactcatcc ggtgtcagcg attgtccatt
     9121 aactaaatac cgtgcacgct ccgaattttg attatccatg cgccgaaata attgattgaa
     9181 aacatcatcc atatcattgt tgaaaaaagg atcatttccg tagaaatttg ccatattaca
     9241 acacctccat aaaaatttat atgtgtaact tagtgaccat aatatccttt aaaactacaa
     9301 ctgaatcgta tcacgatttt tatgtatcgt taagtaaagt gcttatagaa tcaattagaa
     9361 ataattagaa taattttgtt taaacaaaag agaaatcaat ttcataaaat gaattgattt
     9421 ccctacaagg ttccctattt aatagccctt gataaagaac ttgaattaac aagttacttt
     9481 ccagaccaat tttaatttaa gagactgcga ctcaaaaagc acacccagta tcaagttaag
     9541 gccaactagt tatcgttaat attgccactt aaatatcaat actagcaatc atgatacacg
     9601 tgtaaaatca taaaccaaaa catattacat gacgtaacgg cggtcttggg actgtaaact
     9661 cacagtaatg attctattga gttggataag gtgccgatga ccagtaattg ccataaatgc
     9721 aattgctttc ggtacaatcg tagtgacata gccaactgtc tcggccatct gcccatttgt
     9781 tttataaaac cgtaatgaga ctcgacattt ttgatcatgc gcttgttgta atttacaata
     9841 attattttca acactcaaat taaagtctcc cgttcaaaga attcaggttt atttattcgt
     9901 cagtgaatct atgtgtttgt ttttctcatt gttgacggcg taagtccaca ttaaggagtc
     9961 agctattcag taaaaactaa ataactagta ttcatgttca gctcagtata atatgcattg
    10021 atggttacta atcaaaaatc gatctctaaa tatcctaatt actatgaaac tttgaagtta
    10081 atttatgaga aaaataactc acaacaaaac tcatgattac aaccttgtca tcataactag
    10141 attatgaaac attcagcctc ctaaataaaa ctggtatgcg cgcatgtgcg catgtgtaca
    10201 gtatactatt gccaggtatg tctgaataac cgttttaaga cttgaaaaac tcagctgggt
    10261 gctttaggac gctttttgtg cattttaaga caatatccta acttcaacgc cggcatagct
    10321 tcaattcgtc aatcagtgtc ttagttcctc agctatttct gttcagaaca tcttcctatt
    10381 acaataaaaa gcgttgatct cagcagaatt tacttccacc aaaaccaacg ctaaagtgtt
    10441 attatatcag gtattttaaa ttcatttcag acattatatt cagcattact tctactacct
    10501 aagtaattta gcacgtttaa catcttcaat cgtcttagtt cccgctagtt gcatatcgat
    10561 caacagctca tcattaaggt gactcactac ggaagcgaca ccctgcgcac cacccaatgc
    10621 taatccatag ataatcggcc gagcaagtgc caccagatct gcaccattgg ctaacgcctt
    10681 aaagacatgg gagccacgcc gaacaccgct atcaaaaatt gttgggacgc gcccattaac
    10741 ggcttgcgca atctcgtgta aaacatcaaa ggaagctgga ccaccattta attgccgacc
    10801 gccatggttt gaaacataga taccttgagc accagccccg attgctaaca aggcatcttc
    10861 tggttactga atccccttca caataactgg taaattcgta tattctgtaa tacgccgaac
    10921 atcagctggg ctaatctttt gcgccgcagc agcatagatt tctatgatac ctttcccttt
    10981 accatcccct tcgctgaact tagtcaagtt agccattggg attggaaact ggaaattgtt
    11041 gataatatca gcttcacgat acccgtcaac tgttgcatca acagtcaaaa tgattgcctt
    11101 agcaccagcc ttcactgctt catccaataa actctgattg aaattccaat ccttgctcat
    11161 atataattgg aaaaattggg gcgcaccttt accagctgcg gcagtatccg caattgacgt
    11221 tgaagaataa gtactctgag ccatgagtgc cccaacttga gccatccctt cagcagtcgc
    11281 agcttcaccc cgtgcatgtg ccaatccttg agcggccgct ggagccatca taataggcgt
    11341 tttgagatct atgccaaaag cctgagtctg tgtgcttggc tgttccatat ccgtcaatgc
    11401 tcgtggcaca atttgaacat ggttaaaggc cattgtattc tgctttaaag tccattcgtc
    11461 ttctgaccca ccactaatat agccaaagcc tccgctcggg atgatctttt tagcagctgc
    11521 ttccaatgat ggtaaattta aaatcgttaa cttttgctca cgatcactct gttcatatcc
    11581 attaataact gtcattatac taatctcctt tacataaccc tttataattc atttaataat
    11641 tggctaagtg ccggttgatc cgcttcagcg ataccatatc gttcacgata cttagcaatc
    11701 gtatctgcat caaagttttc tggatctact ggaacaaaac tagtatcaat tggatcaaca
    11761 tttttaattt ttgcatcaat cacaattggt agttgattac cattctgctg tagttgagta
    11821 actttctgaa acgttgcttt caactcttta aggttagtca ctttaaaacc aatcgcaccc
    11881 atgttgtctg ccatcttggc ccaatcagca ccaatcaagt caatcccata cggcgcctga
    11941 ttagcgagta acttttcatg ttgaataaag cctaatactt tgttttctaa aaccacgtta
    12001 atgactggca aatgatattt aacttccgtt agtaagtctg gcatcaccat ggcataacca
    12061 ccatcaccag aaatactcca aacctgcttc ttaggataat tcaattgggc ggccaaacct
    12121 gctggcaaac caaaacccat cgtgccatac caagccgaca tcgtaaaagt ctgttgctta
    12181 ttcaatggta actgtcggat tgcccattcc gtattattcc caacatccag accaaagacg
    12241 gcatcatcag tagcattgtc tttaatagct tctagcaccc cttcagccgt caaccctcct
    12301 tgatcatcag tagcaattgt cttgagccac cggttccagt tttgcttatc acgttgagca
    12361 gctttcaaga acttagttgg cttaattgtc acttcggatt gaagtaatgc ttggaaaaat
    12421 tcttttgcat ctgcaagaac agtaatatca gcatcatgtt gtttgcctaa atctgctaaa
    12481 ttattattga cttgaataaa cttaattcct tgtggcaagt aacgtgcaaa tggaaagtta
    12541 gtaccaacaa acaaaactag atctgccgct tgcgagactt caaaggcggg tttagttcct
    12601 agtcgaccgc gagagcccat gaaattagga tggtcagttg gcataatacc agttgctgga
    12661 gccgtcgaca aaaccggcaa actaaatttt tcagaaactg cgataacttc ttgacgcgca
    12721 ttataggcac ccttgccaat ccataaaaca gggtgttgag cagctttcaa agccgctatc
    12781 gtctgctgaa cgtcatctaa tttcggcatt aagacctgtt gactgccgct aagtgaagcc
    12841 gttttaaaac catcaaactc aatatcttga ccagacaaat catctggaat aataacaaca
    12901 gaaaccgaac gggtcgcgta tgctgatcta attgcttcat caaccacgta tggaatctgt
    12961 tcagccgttg tcacttgttt atgaaattcg gctacatctg caaaaattgg atcttggttc
    13021 atttcttgaa agaagttcgt attcataatg gatgttgctg attgaccgac taaagctagc
    13081 accggtacgt gatccatctt ggcatcgtat aatccgttca agagatgaac ggcgcccggt
    13141 cctgctgaac caaagctaac accaatcgtc ccagttaatt tagcatctgc cgcggcagct
    13201 aaagcaccaa cttcttcatg acgtacttga atatacttca agtggtcttt ctcttggtag
    13261 aacccatcta ccgtgttatt aatcgagtca gctgtaatac catagatatg atcaatgttc
    13321 cagtcgacta acacttgtgc caatgcttgt cctgctttaa ttttagtcat ttccattacc
    13381 ctctttttgt tgttactttt ttgagcacaa ctatatccta aataaaaact tgacccttgt
    13441 caagtcttta tcttaaatta tgcttgttgt tgaacagcgc taatgtcatc aataatatct
    13501 tgcagcgtca ctcgcgacat acgtgcctca gcactattct gaatatcaca atagtatttt
    13561 tccatcactc gcggaattac cgacccgacc ggacacgtct ccgaagtatt atgatcaacg
    13621 tttaaaaaat tacgcttagc caccactgct acatagatat ctttcaaggt aatatcattg
    13681 ggcgaacaag ctaatgttgg tctagcaacg ccacgaaccg aagttaacaa gcctgctttt
    13741 cttaacttac tcatcattct tctgaccatg gtaggatccg tatttaaact actagcaata
    13801 tgctcacttt tcagctggtc atcagtatgc aacgcaatat atgccataat atgcgtcgca
    13861 tcacttaatt gtgtattagc catctagaca cctcccatat ccatctctat tgttacttat
    13921 tttagcacat ctaacatgaa cataaaagcg attaaggaaa taagttaggc ttctttccct
    13981 aatcgcaaca taagattatt tgataatctc cattaattca atcaaactta ttcaagacat
    14041 cgatagtagc tgaatttaaa acccaccctg tccaatttga tgttgcaaat catctaagcc
    14101 aaattgtttt aaataagttg aaagtggttg taaatcttga gcttcatacc gttgtttaaa
    14161 tgcttcaata tcagctgccg aactcgttgc cgaatctaaa cgaagctttt cagcaggcag
    14221 tggccgatct cctgtaatca ccgcatcaat cagaactggt tcatgctgag cgattgcttt
    14281 ggcttgttca aaaacatcag gtaattgctc aatcttatta actcgaaaag cttgcatgtg
    14341 cacgccatcg gcaatcttac taaaatcaat atcattgaat tcaacgccaa taaaatcatt
    14401 ctgattagta tcttcctgct catctttgat aaatccatat tggcagttgg tgaaaacaac
    14461 attaatcact ggtaaatggt attgaacttg cgtcgccaaa tcttgcatgg tcatcgaagc
    14521 gccaccatca ccggccagat taaacacctg ccgctcagga taattaagtt tggcagcaat
    14581 tgctcccgga ataccaactc ccatcgtagc aaataagtta gaagtaatgt gccgattgga
    14641 cggcgttaat ttcaaatgtc gattcgcatt caaattgata tcaccaacat caatcgaata
    14701 gattgcatca ggctccgcaa ttttattaac cgcacgtagc acttgatatg cttgtaaagg
    14761 cccttcctgc ttatcttcta atgaagctag ataagcccgc caatttttaa cattggctaa
    14821 attggcttgc caccaaggtg tcgactcccg ttcagatacc tgtgctaaaa ttgcagccag
    14881 cgttttttgt gcatcagcaa gtaccgcaat atctgtttta tgtcgtttac ctaacttagc
    14941 tggatcaata tcaatttgta agaaataacg cgtattttta aacgctttgg aaacttctgc
    15001 aaacggataa ttattaccaa caaataaaac aacgtcggct tgcgcaagtg cctcattcgc
    15061 cggtttttgt gccacccgat tagcagaacc caaataggct ggataacgat ccgcgacaat
    15121 acccttagct ggatacgtac tcattaatgg aattttcaac gttttactca attgttcgag
    15181 ttctttacca gccttacgag ctccaatgcc atagtaaata agtggccgtt cagctgcgag
    15241 taaagtctgt gtcaatctcg tcactgcttg aacgtcgggt tctggtaata acggcgtttg
    15301 ataactatta gcggaagcat accaatcttc agctggaatc tgttgccatg gtaaatcgac
    15361 tggaatttgc acaaccgcaa caccttggtg cgcgtaggcg cgtcgaattg cttcgtcaat
    15421 aacatgtggc aacgtggcag cattgacggc tgttacatta taatctgcaa cgtccgcata
    15481 aatcggattc tcattcattt cttggaacgt atccatgttc atcccagtag ttccaaattg
    15541 accaataagt gctagaacag ggacatggtc ttcacgcgca tcatataacc cattcataag
    15601 atgagtgcca ccaggtcccg ctgagccgaa gcaaaccccg attttacccg ttagcttagc
    15661 atcagcagcg gcggccattg caccaacttc ttcatgccgt acttgaatat aatggattcg
    15721 atccctttct gctgataatg cgtccataat tgaattaatt gaacctccag gaataccata
    15781 caaatgatct actccccaag cttctaaaac tttaataact gctgcacctg ctagtatgtt
    15841 agtttgtttt gtttgtttca taaccataat aaagccccca tttcatgcac aatttaatta
    15901 cgcacaattt aataaacgaa tattaccata gcaaacgctt acattcaagt ggtcataaac
    15961 tcatgctttt taccacttaa tcacgattca aacgcattgt agatcaacaa cagcgctagt
    16021 ctgcttgcct tgatgaacca ccatcgctgt tgacagttag tatctcatac attcattttt
    16081 taaacaattt tagtaattag tgtatgtttt acaggggcat acttccaaca atgtctgcat
    16141 gtttagaagc tagccattct tcgaaaacta actaccgctt tcaaaacatg accttaactc
    16201 aactcgacac agagcaaaat aacatctgcc aagttaatta ttcagctata atccgtacca
    16261 cgctaccaac tttaaaatca ggataatcgc cctgctcaac atataacgtc ccaggcaatt
    16321 tagcctcctt tgcacccgta aaactaatag ccgtatggcc taatcttcca aggttagtct
    16381 ggacttcacc accaactgct gtaatttgat agacttgatt gtcgacttca agtttcattc
    16441 ctgctgtgat ttgctcactt attgggacaa cttcgataat aaagcaagaa ggccgtaatg
    16501 cgtctggagc ttcatcacca aataatactg ccatgccaat cgatttaaaa tcagcagatt
    16561 ccgcacctat ttctaagacc tttgttgaaa agataattct ctcttttgtc atcatacaat
    16621 acacctcaaa ccttctaaaa atttattttg aatataatcc aaaacttgca atccaagcaa
    16681 taaagacccg cggaacgccg ttgataaacc gactatataa cactgatggc accccaactt
    16741 caaccgtctt ag
//
