LOCUS       gnlProkkaNPEPPOKF_33   16746 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NPEPPOKF_33.
ACCESSION   gnlProkkaNPEPPOKF_33
VERSION     gnlProkkaNPEPPOKF_33
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 07:23:13
            Original ID  :: gnl|Prokka|NPEPPOKF_33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16746
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..87
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="MFSHSKTPEIVVQSRGFTSAIEKLDLFV"
     protocluster    1..16746
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6040:6746]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6041..6746
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16746
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16746
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(143..487)
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLYRKSVNWLSV
                     VMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAIFYFIKALEK
                     RHVFDRMRLR"
     CDS             complement(886..1020)
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MIKSILKFCLAATLIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             complement(1037..1282)
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             1568..3082
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MLAFKLCKSFLVIYVKRAIKMTEKLTTETGQPWANNEHSQTAGAR
                     GPVLMQDYNLLEKLAHFDRERIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKK
                     TPVILRFSQVAGEKGYPDTVRDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFI
                     HSQKRDPKTNRRTQNMQWDFWAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVN
                     QNGEQFWVKYHFISDQGVKNMTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQI
                     LPYEEGLNYKWDIFDVTKVISHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPG
                     IEPSPDKLLQGRLFSYKDAQRYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVN
                     YEPNALHGPEEVPDAALSPDSVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINT
                     IKDALGQVTLPGVKKLEIKQFYEADKNYGTRVANALGMNIADIISD"
     CDS             complement(3240..3677)
                     /locus_tag="ctg33_6"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(4033..4776)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(4769..6031)
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(6041..6169)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_9"
                     /sec_met_domain="TIGR04223 (E-value: 2e-08, bitscore: 25.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             complement(6150..6746)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="AgrB (E-value: 1.6e-35, bitscore: 113.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IETGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(7341..9455)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     962; E-value: 4.5e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEATKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(9846..10079)
                     /locus_tag="ctg33_12"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(10716..11072)
                     /locus_tag="ctg33_13"
                     /transl_table=11
                     /translation="MLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRVPTI
                     FDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQLAG
                     TKTIEDVKRAKLLR"
     CDS             complement(11085..11816)
                     /locus_tag="ctg33_14"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWNFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIIEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQ"
     CDS             complement(11843..13597)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 471.4;
                     E-value: 6.8e-143)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_15"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-41, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-32, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDH
                     LKYIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVG
                     QSATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVII
                     PDDLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQ
                     EVIAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNF
                     PFARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAA
                     QRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLN
                     KQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPV
                     INVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQ
                     KVTQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPA
                     LSQLLNEL"
     CDS             complement(13679..14104)
                     /locus_tag="ctg33_16"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             complement(14277..16088)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 494.2;
                     E-value: 8.6e-150)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_17"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-44, bitscore:
                     142.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-38, bitscore:
                     123.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLTPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSATSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
ORIGIN
        1 aaatttagtc atagtaaaac ccccgagatt gttgtccaat ctcgggggtt cacttcagca
       61 atagaaaagt tagacttatt tgtttaacga ttgtagcgcg tttcataccg tgttcaacct
      121 ctttttgtag catccatcga tattatctaa gcctcattct atcaaaaacg tgtcgttttt
      181 ctaacgcctt aatgaagtaa aaaatagcaa tcacctgtaa tggtatctga atgatgacgc
      241 gtgccaatct tcccaacaat aacactttaa aattagtgcc aaatagcact gaaattagcc
      301 atgagtccat catcaaacta acaaaaatca ttacaagtat ttgcgtcatc acaacggata
      361 accaattgac tgatttacga tataaaaaca aaccgtcaat aaatccccct aaaaatgcag
      421 ttaacaaaaa ggcaatctga aacgcgccgg aaccaaaaat agtaaagctt aatatatcgg
      481 agatcatctc caagagacca ccccaaatgg gaccatatag ataaccaata caagccatag
      541 acaaaaagcc aaaagataat tgaaaatacg ctggtccgat agcaattttg tataaaataa
      601 cgtctaaggc caataagaaa gccgatgtag tcagcactaa taaattcatt tttggcaact
      661 gaaaaacatt tttcgcaata agtttagaca taggccaatc ctcttttttt gattttaatc
      721 ataccctcat tcttaataaa agtaaatatt acttttattc gattgaaggt agtttaaaat
      781 cgtcgctctt gatttagttc cttgaactca atgatattac tcatactaaa agccactaac
      841 aggtcaacta gtacacccat cagtggctca ttgtaaaatt aatttttatc catgtaactt
      901 atcttgtaat ttatcaccca agttatcaat tcccttagca gtaagtacgg tcccaccaat
      961 aagaacacca cttacgatta aggttgcagc taaacaaaac tttaaaatgc ttttaatcat
     1021 cgcaatcatc tccttactaa tccatccgtg tcagaacaaa tgaggttatc gcaacaacaa
     1081 tcacaccacc aataattgaa ggaacaattg ccattccggc taattgtggt ccccatgatc
     1141 ccaaaagagc ttccccaatt gcagatccaa ccaatccggc aataatatta ctaatccacc
     1201 ccatcgattt acctttatta gtaatagcac ctgcaattgc accaataata gcaccaatga
     1261 tcaaaaccca taaccaatgc ataaaatccc tcctagactt attaaaccgc ttaaatacaa
     1321 taatagaatt acacgaatat ttaagccgat tcataaatga ttacttctta taattatcat
     1381 tttacaatta tcgataatga tagacaaata taacacatta tttaataaat gggtcgctac
     1441 tatttctcat gtgacgattc cgggtggcct agaaaatatc aaacagcttg atagctgatt
     1501 aaaattaaac tacgccacat gaacgattaa cttaactgtg cataatgatt gaagtcactc
     1561 tgttaaggtg ttagcgttta aattgtgcaa gagctttctt gtaatttacg tgaaaagggc
     1621 gattaaaatg acggaaaaat taacgacgga aaccggccaa ccatgggcta acaatgaaca
     1681 ttcccaaacg gcaggagctc gtggtcccgt attaatgcaa gactataatc ttttggaaaa
     1741 actagcccat tttgatcgtg aacgaattcc agaacgggtc gttcatgcta agggggccgg
     1801 agcaaaaggt ttttttgaac ttgaaaacga catgggggaa tatactaagg cagacttatt
     1861 taatggtgtc ggtaagaaaa ctcccgtaat cttaaggttc tcacaagttg ccggtgaaaa
     1921 aggttatcct gacaccgttc gagacgtgcg cggttttgcc ttaaaatttt atactcagca
     1981 aggcaattat gatctcgttg gaaacaacac accggtcttt tttgtaaacg accctttaaa
     2041 atttcctgac ttcatccatt cacaaaaacg ggatcctaaa acgaaccgtc gtacgcaaaa
     2101 tatgcaatgg gatttttggg ctcattctcc agaatcattg caccaggtca cttatttaat
     2161 gggcgaccga ggtcttcctg cgtcctatcg aaccatgaat ggttacggtt cccatacttt
     2221 taaatgggtt aatcagaatg gcgaacagtt ttgggttaag tatcacttca tctcagacca
     2281 aggcgttaaa aatatgactg ctcaagcagc tgaaaaagca atgagccaag atttagatta
     2341 cttacaagat gacttatatg atgcaattca agaaaaaaat tacccatcat ggacgatgta
     2401 tgtccaaatc ttgccatatg aggaaggtct aaactataaa tgggacattt ttgatgtcac
     2461 taaagtcatc tcccacaaag actatccact aattaaagtc ggcaaactaa ctttaaatga
     2521 gaatcccact aataacttta ccgatattga agaggcggcc atgtcgccag caaattttgt
     2581 tcctggtatc gaaccatctc ccgacaaatt actacaaggt cgcctattct cctataaaga
     2641 tgcacagcga tatcggttag gtgccaactt tgaagattta cccgtgaaca agccggttgt
     2701 tccagttcat aattatgaac gtgatggtta catgaaaatt aataatcaag gtgctgaggt
     2761 caactacgag cctaatgcac tgcatgggcc agaagaggtg ccggatgccg cactttcacc
     2821 tgattctgtt cgtggtgaaa cacgcgcaca gccttatcgc tatcaagttg attacacaac
     2881 tcaagcaggc gacctatatc gcttaatgtc agaacccgag caagaacgct taattaatac
     2941 tatcaaagat gcgttaggcc aagttacttt gcctggtgtc aaaaaactcg aaatcaagca
     3001 attttatgag gccgacaaaa actacggtac acgcgtggct aatgctctgg gaatgaatat
     3061 tgctgatatt atcagtgatt aatattttga ccggatgtta tccagcgcga tattattttt
     3121 gttataaaga atgatgatgc cgtctcatgg ttattaacta aagagcgaca ggttagactc
     3181 atatcgtgta agtctagctt gtcgctcttt aattaacaaa aaatcttaga tatagcttac
     3241 tactcgacca tccttttatt aataatgtga tcccctgtat taccatctag acgactcaac
     3301 aatgcattga actttagtcg ccgaactggt cgtggaataa attggcgaat atcatcttca
     3361 ttaaagccaa cttgaatttt actatcacta atgatgatag gccgacgtaa caacttcgga
     3421 tgatcacaca acaatttaag tgcctcattc aatggcattt cgggtaactt aggcgcaatt
     3481 tcaggatagt ctttagatcg agctgagata atatcgtcta caccatgttc ggttaaactc
     3541 aaaatacgtt ttagatcttg caccgtgggc gaatcaacac taaaattttt ctccttgaac
     3601 tcaatcccat gtgcttccaa ccattgccgt gcaactctag aagaatgaca gcttgattgt
     3661 gtatataacc taatcattcc taatctgccc ctctctcgtt aaaattcatc acagcgtatt
     3721 gatcgacatt aacttctgcc tgtcacaaca tcctttaaac taaacgcatt cgttactgtc
     3781 atgaccaatc caataccccg tgaacacatc tttattatag gctctgaaca agggacatac
     3841 cgaccgtttt aagacgaata atctgaggat aatcgtttta agtacacttt taaacggttt
     3901 aggaaagaac gaacccagta cacgtaatgc taacaaatat cactgcaatt tctaatcgaa
     3961 taacgctgaa ttttcatcgc gtagcacata aaaagtcgcc tactaattta acaggcgact
     4021 tccttggaac tattatgact ttttagcaag ccatttagct agataacgat tagcttgtgc
     4081 agaacaaagc actttttcac catttgtcat ggttaatcgt cgcaagtgct tgtccaatga
     4141 cttaatgcgt ttcaagttaa caacatatga cttatgacac ctatagaaat taggactcaa
     4201 atcaggaacg tcctttaaca gtccatagta ttctaattca ccatcatcca aatggactac
     4261 gattttatgg ggactggttg aactttcaaa aaatataatg cttttaacat taattgatct
     4321 gaccgtctca ccaattttta tttgaacata gtcgtcttgg tcattttcat cggtttgaaa
     4381 acgatcttgc gccacgtgta aaaccttgct aaatcgctca tacaaggaat ctggaaaatc
     4441 cttaagaata aaatctaatg cctcaacttg atattgaaac accatcaaag ataactccgt
     4501 gtgtgtcgtg ataaaaataa tcttgctgcg acggcccatg tcacgaatct ggctagctag
     4561 ttgaatacca ttaatatctg aattaagggc aatatctaac acatagattg ccttttgagg
     4621 ctgctgtgca ttaaccttgt ctaacaattc gtggggatct tggcatgcta aacagatact
     4681 catgtctagc tgttgatcga cgattacctt agtaatgatt tgccgtattt gttgtaattg
     4741 tttcggatca tcttcgcaaa tgtagacact aatcattctg agatactcgc ttcaccgtca
     4801 agcgttgtaa gaataccgct cctaagactc tggtttcgag tatcatgttc tcattgcgat
     4861 taacaatctt acttaaacta ttcaatccaa tcccccgatt cttgccctta gtggaataac
     4921 ctgcctcttt cagcttccat aagggtggta actgttcaaa aacattgttt tgaatcaaga
     4981 acaccgtact atttttttcg ataaaaatgg cactcataat ctctccatca gcatgtccta
     5041 ccgatgcttc gattgcatta tccaacataa tccctaatgc aatgtctaaa tccaattcat
     5101 taacagtaat gtcaattaat ggttccttta aatcaaaatg aacttcaatc tcttgcgatt
     5161 gtgcatagct caacttacta aataggatac tcttaatcga cttcactttg acccgactca
     5221 aatcttcaag attatatttt tcttttaaca cccgatttga aaccggtgca agattctttt
     5281 gataatattc ttgtaaacct tctaaatcat cagttttcaa atattcatct atcgaaatca
     5341 acatattctg atagtcatgt ctgaaacgtc gcaactcatt atagtgagct tcgatttcat
     5401 tcatatagcg agtatcattt tgtatttgta ttctttgctt ttggacttca tatttggctc
     5461 ttacattttt taaatattcg ttataaatca ccaatactaa ccccattaca actgacaata
     5521 taattaaatt acttaatata acctggaact gattttccag accttcactc aacataatat
     5581 acaagtatat tatcattaat aatagtgcgg ttatgcgatt taagctctga ttactaaacg
     5641 tgggactgaa attcgtgcga tccattacaa tattaagaaa aattaagctt acgacactca
     5701 atatgacaaa cactaccaca tacccattag gaactttcat taaacgagtt aatatatcac
     5761 aaatatggtc aaccataatc gaccatatga acacttgaaa tgttatacat agtgcaccgc
     5821 ttagaactcg tacataccac caagtgaaaa atataaacat cattaacatt aaaaaagaaa
     5881 aactaattcc taactttgct aaaaaaatat aactcatcag catacagacg gataagaata
     5941 taacatcaaa aagtctcaca aaaaatatat ttctcaacaa agatttaatt atcaaataga
     6001 tagataattc ttggaagaca atcattaaca tatatctaca ctaatccttg ctttttaatt
     6061 catcaggaat tttagtttcg aataatatcc catggcagca cataaccaac tgtttagtac
     6121 ctacgtattg aaaaagatgg ctaagtactt tatacatttt ttctttcata attttccctc
     6181 ctttcatagg gcattagtaa taaagcggct aatgccatcg caattaaaat gattgtgcca
     6241 aaataattat tactaactat ttgtaacaaa ctcaaaatta atgacaatcc aattgcccgt
     6301 cgctttaatt tttttctcaa tgacttcgat gtaataggat tctttaccgt atcagctgga
     6361 gcaaaaatac ttatgattat tacaaatatt aaacttaata acaatctgta tacttcagaa
     6421 ataccagttt caatcacata cggcacaccc acaaacacaa agatagttaa tatcgtacat
     6481 aacaaatccg atttcaagtg acgtccatag gcaaagccac gcaaaactaa aaaactaccc
     6541 ataaaaacta acactgggac caactcgtgt agcagcaacg ctaagataat agtaattatc
     6601 agcttaggaa taacatttaa tacagtatca atgcctagtt taactagtaa tgcctgccgt
     6661 ctttctagtt gaagattctt ttgaatcgca gcgaataacc gatcgcttaa tttataaagc
     6721 aatagttttt gttctggctt ttccatatcc cactcctata atgctcaaat acatacctgt
     6781 atcaacagtt taaaacagta ttaattaatt gaaaagaata cataaatata ttaattattc
     6841 aatattgttt taagactaga aatnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7081 nnnnnnnnnn nnnnnnnnnn nnnnnnntca gtttaattat tcatacgaaa ctaaagtttc
     7141 atgtaaaaag atcgttaata taaatcagtt tcatcgatac tcccccttaa tttttcctta
     7201 gattacaagt caaactagac ttaatttcac taattcacat tactcaatag attaatatca
     7261 aatggtgaaa atcaacgaaa agaggagatc tatcaagcaa tctcctctta cataaagtta
     7321 tttatgaaca ctgatttaag ctaagctgcc gatatcacaa tctcagcatc cactaaatca
     7381 gccttcaagt ttttgacatc taagtggtca aggtagaaat ccgttacctt gtcacgaatt
     7441 tgttgttcaa ttactcgccg taatggccgc gcacccatcg cttcatcata gccttgttcc
     7501 atcagccaat ctttggccgc tttagttacc tcaagtttga tggatttttt ggctaacgtt
     7561 ttttgtacat ccgccaacat caaatcgaca atttgactta agtcttgctt agtcagatgt
     7621 gaaaattcca cgattccatt aaaacggttc agaaattctg ggcggaaaaa tggtgctaac
     7681 ttatccatta atgactgatc tcgttgcttg tcaccactta atgcttcatt accaaagcca
     7741 gcattagaag tagcgataat aatcgtattt ttgaaattaa tgacattgcc ttgtccatcc
     7801 gttaagcgcc catcatccat cacttgtaac agtaacgtta atacttgtgg atcagccttt
     7861 tcaatttcat ctaataatac aatggaatat ggattacgcc gaacccgttc ggttagagta
     7921 ttagcattat cttcatagcc tacgtatcca gccgaggtac caattaattt cgacacagct
     7981 gtacgatcag catattcact catatctagc cgaataatcg catttttatt tccaaacata
     8041 tctaaggcta attgcttagc taattcagtc tttcctacgc cagttgggcc cacaaacaga
     8101 aaacttccaa ttggctgatc accctctgaa aagcccgcac ggttacgccg aattgccttc
     8161 gctaccattt caaccgcttc atcttgaccg attaccttac ttttcagacg cttatcaaga
     8221 tttttcaagt gctcaatatc attagcgccc atatcagcaa ctggtatacc agttaaacgt
     8281 tcaaccgatt gtgccacatc atcaatcgtg gcagtgattt tttctttttg atccgttttt
     8341 ttaatttttt gcttggtttc ctcgatcgac ttcttgatat cagcggcttt tgtaaagtcc
     8401 tccgatttaa cggcggcctc cttagttgcc tctaattttt taacgcgttg atccaatgtc
     8461 tcaacatcag tttgcgaatt tttagccgct aaatgagccg cagtcatgtc gatcaaatcg
     8521 atagctttat ctggcaaagt gcgttgtggt atatattgga ttgaataatc cacagccgcc
     8581 ttcaaaacat catctggtaa tacaacatga tgatgctttt cgtacagctt tttaacacct
     8641 tgtaatatac gtaaagtgtc agcggccgtc ggttcattaa tcacaacatc attgaatcgc
     8701 cgtgccaaag ccgcattttt caaaatagta ttgcgatatt catcttgagt cgtagccccg
     8761 attacagtca gctcgccacg tgacaaagca ggtttaatga tatcagccaa tcctttgcca
     8821 ccatcttcac caccagtggc gcccgtgccg ataatctgat gaatttcatc gaagaataga
     8881 ataatattac cagctgcttt aacttccttt actagctgtt taatattttc ttcaaaagaa
     8941 ccgcgatatt gagttcctgc ttccaaagac gataaatcaa tcgaatagat ttctttatct
     9001 tgaatcgttt ctggaacttt accagccaca attgcttgtg ccagaccttc gacgactgca
     9061 gttttaccta caccagcatc accaactaag attggattat ttttcgtcct acgactcaaa
     9121 atttctgcag tttcttgaat ctcattctca cgtccaatca ctggatctag taatccatca
     9181 cgagcctgtt ccgtcaaatt agtccctaac ttttctaaaa tccccccttt tttaacagcc
     9241 tgtttaccat ctttagatac ttctattgtt ttattatttt ggggtagctt accagttgct
     9301 cggtattgag caaactcatc cggtgtcagc gattgtccat taactaaata ccgtgcacgc
     9361 tccgaatttt gattatccat gcgccgaaat aattgattga aaacatcatc catatcattg
     9421 ttgaaaaaag gatcatttcc gtagaaattt gccatattac aacacctcca taaaaattta
     9481 tatgtgtaac ttagtgacca taatatcctt taaaactaca actgaatcgt atcacgattt
     9541 ttatgtatcg ttaagtaaag tgcttataga atcaattaga aataattaga ataattttgt
     9601 ttaaacaaaa gagaaatcaa tttcataaaa tgaattgatt tccctacaag gttccctatt
     9661 taatagccct tgataaagaa cttgaattaa caagttactt tccagaccaa ttttaattta
     9721 agagactgcg actcaaaaag cacacccagt atcaagttaa ggccaactag ttatcgttaa
     9781 tattgccact taaatatcaa tactagcaat catgatacac gtgtaaaatc ataaaccaaa
     9841 acatattaca tgacgtaacg gcggtcttgg gactgtaaac tcacagtaat gattctattg
     9901 agttggataa ggtgccgatg accagtaatt gccataaatg caattgcttt cggtacaatc
     9961 gtagtgacat agccaactgt ctcggccatc tgcccatttg ttttataaaa ccgtaatgag
    10021 actcgacatt tttgatcatg cgcttgttgt aatttacaat aattattttc aacactcaaa
    10081 ttaaagtctc ccgttcaaag aattcaggtt tatttattcg tcagtgaatc tatgtgtttg
    10141 tttttctcat tgttgacggc gtaagtccac attaaggagt cagctattca gtaaaaacta
    10201 aataactagt attcatgttc agctcagtat aatatgcatt gatggttact aatcaaaaat
    10261 cgatctctaa atatcctaat tactatgaaa ctttgaagtt aatttatgag aaaaataact
    10321 cacaacaaaa ctcatgatta caaccttgtc atcataacta gattatgaaa cattcagcct
    10381 cctaaataaa actggtatgc gcgcatgtgc gcatgtgtac agtatactat tgccaggtat
    10441 gtctgaataa ccgttttaag acttgaaaaa ctcagctggg tgctttagga cgctttttgt
    10501 gcattttaag acaatatcct aacttcaacg ccggcatagc ttcaattcgt caatcagtgt
    10561 cttagttcct cagctatttc tgttcagaac atcttcctat tacaataaaa agcgttgatc
    10621 tcagcagaat ttacttccac caaaaccaac gctaaagtgt tattatatca ggtattttaa
    10681 attcatttca gacattatat tcagcattac ttctactacc taagtaattt agcacgttta
    10741 acatcttcaa tcgtcttagt tcccgctagt tgcatatcga tcaacagctc atcattaagg
    10801 tgactcacta cggaagcgac accctgcgca ccacccaatg ctaatccata gataatcggc
    10861 cgagcaagtg ccaccagatc tgcaccattg gctaacgcct taaagacatg ggagccacgc
    10921 cgaacaccgc tatcaaaaat tgttgggacg cgcccattaa cggcttgcgc aatctcgtgt
    10981 aaaacatcaa aggaagctgg accaccattt aattgccgac cgccatggtt tgaaacatag
    11041 ataccttgag caccagcccc gattgctaac aaggcatctt ctggttactg aatccccttc
    11101 acaataactg gtaaattcgt atattctgta atacgccgaa catcagctgg gctaatcttt
    11161 tgcgccgcag cagcatagat ttctatgata cctttccctt taccatcccc ttcgctgaac
    11221 ttagtcaagt tagccattgg gattggaaac tggaaattgt tgataatatc agcttcacga
    11281 tacccgtcaa ctgttgcatc aacagtcaaa atgattgcct tagcaccagc cttcactgct
    11341 tcatccaata aactctgatt gaaattccaa tccttgctca tatataattg gaaaaattgg
    11401 ggcgcacctt taccagctgc ggcagtatcc gcaattgacg ttgaagaata agtactctga
    11461 gccatgagtg ccccaacttg agccatccct tcagcagtcg cagcttcacc ccgtgcatgt
    11521 gccaatcctt gagcggccgc tggagccatc ataataggcg ttttgagatc tatgccaaaa
    11581 gcctgagtct gtgtgcttgg ctgttccata tccgtcaatg ctcgtggcac aatttgaaca
    11641 tggttaaagg ccattgtatt ctgctttaaa gtccattcgt cttctgaccc accactaata
    11701 tagccaaagc ctccgctcgg gatgatcttt ttagcagctg cttccaatga tggtaaattt
    11761 aaaatcgtta acttttgctc acgatcactc tgttcatatc cattaataac tgtcattata
    11821 ctaatctcct ttacataacc ctttataatt catttaataa ttggctaagt gccggttgat
    11881 ccgcttcagc gataccatat cgttcacgat acttagcaat cgtatctgca tcaaagtttt
    11941 ctggatctac tggaacaaaa ctagtatcaa ttggatcaac atttttaatt tttgcatcaa
    12001 tcacaattgg tagttgatta ccattctgct gtagttgagt aactttctga aacgttgctt
    12061 tcaactcttt aaggttagtc actttaaaac caatcgcacc catgttgtct gccatcttgg
    12121 cccaatcagc accaatcaag tcaatcccat acggcgcctg attagcgagt aacttttcat
    12181 gttgaataaa gcctaatact ttgttttcta aaaccacgtt aatgactggc aaatgatatt
    12241 taacttccgt tagtaagtct ggcatcacca tggcataacc accatcacca gaaatactcc
    12301 aaacctgctt cttaggataa ttcaattggg cggccaaacc tgctggcaaa ccaaaaccca
    12361 tcgtgccata ccaagccgac atcgtaaaag tctgttgctt attcaatggt aactgtcgga
    12421 ttgcccattc cgtattattc ccaacatcca gaccaaagac ggcatcatca gtagcattgt
    12481 ctttaatagc ttctagcacc ccttcagccg tcaaccctcc ttgatcatca gtagcaattg
    12541 tcttgagcca ccggttccag ttttgcttat cacgttgagc agctttcaag aacttagttg
    12601 gcttaattgt cacttcggat tgaagtaatg cttggaaaaa ttcttttgca tctgcaagaa
    12661 cagtaatatc agcatcatgt tgtttgccta aatctgctaa attattattg acttgaataa
    12721 acttaattcc ttgtggcaag taacgtgcaa atggaaagtt agtaccaaca aacaaaacta
    12781 gatctgccgc ttgcgagact tcaaaggcgg gtttagttcc tagtcgaccg cgagagccca
    12841 tgaaattagg atggtcagtt ggcataatac cagttgctgg agccgtcgac aaaaccggca
    12901 aactaaattt ttcagaaact gcgataactt cttgacgcgc attataggca cccttgccaa
    12961 tccataaaac agggtgttga gcagctttca aagccgctat cgtctgctga acgtcatcta
    13021 atttcggcat taagacctgt tgactgccgc taagtgaagc cgttttaaaa ccatcaaact
    13081 caatatcttg accagacaaa tcatctggaa taataacaac agaaaccgaa cgggtcgcgt
    13141 atgctgatct aattgcttca tcaaccacgt atggaatctg ttcagccgtt gtcacttgtt
    13201 tatgaaattc ggctacatct gcaaaaattg gatcttggtt catttcttga aagaagttcg
    13261 tattcataat ggatgttgct gattgaccga ctaaagctag caccggtacg tgatccatct
    13321 tggcatcgta taatccgttc aagagatgaa cggcgcccgg tcctgctgaa ccaaagctaa
    13381 caccaatcgt cccagttaat ttagcatctg ccgcggcagc taaagcacca acttcttcat
    13441 gacgtacttg aatatacttc aagtggtctt tctcttggta gaacccatct accgtgttat
    13501 taatcgagtc agctgtaata ccatagatat gatcaatgtt ccagtcgact aacacttgtg
    13561 ccaatgcttg tcctgcttta attttagtca tttccattac cctctttttg ttgttacttt
    13621 tttgagcaca actatatcct aaataaaaac ttgacccttg tcaagtcttt atcttaaatt
    13681 atgcttgttg ttgaacagcg ctaatgtcat caataatatc ttgcagcgtc actcgcgaca
    13741 tacgtgcctc agcactattc tgaatatcac aatagtattt ttccatcact cgcggaatta
    13801 ccgacccgac cggacacgtc tccgaagtat tatgatcaac gtttaaaaaa ttacgcttag
    13861 ccaccactgc tacatagata tctttcaagg taatatcatt gggcgaacaa gctaatgttg
    13921 gtctagcaac gccacgaacc gaagttaaca agcctgcttt tcttaactta ctcatcattc
    13981 ttctgaccat ggtaggatcc gtatttaaac tactagcaat atgctcactt ttcagctggt
    14041 catcagtatg caacgcaata tatgccataa tatgcgtcgc atcacttaat tgtgtattag
    14101 ccatctagac acctcccata tccatctcta ttgttactta ttttagcaca tctaacatga
    14161 acataaaagc gattaaggaa ataagttagg cttctttccc taatcgcaac ataagattat
    14221 ttgataatct ccattaattc aatcaaactt attcaagaca tcgatagtag ctgaatttaa
    14281 aacccaccct gtccaatttg atgttgcaaa tcatctaagc caaattgttt taaataagtt
    14341 gaaagtggtt gtaaatcttg agcttcatac cgttgtttaa atgcttcaat atcagctgcc
    14401 gaactcgttg ccgaatctaa acgaagcttt tcagcaggca gtggccgatc tcctgtaatc
    14461 accgcatcaa tcagaactgg ttcatgctga gcgattgctt tggcttgttc aaaaacatca
    14521 ggtaattgct caatcttatt aactcgaaaa gcttgcatgt gcacgccatc ggcaatctta
    14581 ctaaaatcaa tatcattgaa ttcaacgcca ataaaatcat tctgattagt atcttcctgc
    14641 tcatctttga taaatccata ttggcagttg gtgaaaacaa cattaatcac tggtaaatgg
    14701 tattgaactt gcgtcgccaa atcttgcatg gtcatcgaag cgccaccatc accggccaga
    14761 ttaaacacct gccgctcagg ataattaagt ttggcagcaa ttgctcccgg aataccaact
    14821 cccatcgtag caaataagtt agaagtaatg tgccgattgg acggcgttaa tttcaaatgt
    14881 cgattcgcat tcaaattgat atcaccaaca tcaatcgaat agattgcatc aggctccgca
    14941 attttattaa ccgcacgtag cacttgatat gcttgtaaag gcccttcctg cttatcttct
    15001 aatgaagcta gataagcccg ccaattttta acattggcta aattggcttg ccaccaaggt
    15061 gtcgactccc gttcagatac ctgtgctaaa attgcagcca gcgttttttg tgcatcagca
    15121 agtaccgcaa tatctgtttt atgtcgttta cctaacttag ctggatcaat atcaatttgt
    15181 aagaaataac gcgtattttt aaacgctttg gaaacttctg caaacggata attattacca
    15241 acaaataaaa caacgtcggc ttgcgcaagt gcctcattcg ccggtttttg tgccacccga
    15301 ttagcagaac ccaaataggc tggataacga tccgcgacaa tacccttagc tggatacgta
    15361 ctcattaatg gaattttcaa cgttttactc aattgttcga gttctttacc agccttacga
    15421 gctccaatgc catagtaaat aagtggccgt tcagctgcga gtaaagtctg tgtcaatctc
    15481 gtcactgctt gaacgtcggg ttctggtaat aacggcgttt gataactatt agcggaagca
    15541 taccaatctt cagctggaat ctgttgccat ggtaaatcga ctggaatttg cacaaccgca
    15601 acaccttggt gcgcgtaggc gcgtcgaatt gcttcgtcaa taacatgtgg caacgtggca
    15661 gcattgacgg ctgttacatt ataatctgca acgtccgcat aaatcggatt ctcattcatt
    15721 tcttggaacg tatccatgtt catcccagta gttccaaatt gaccaataag tgctagaaca
    15781 gggacatggt cttcacgcgc atcatataac ccattcataa gatgagtgcc accaggtccc
    15841 gctgagccga agcaaacccc gattttaccc gttagcttag catcagcagc ggcggccatt
    15901 gcaccaactt cttcatgccg tacttgaata taatggattc gatccctttc tgctgataat
    15961 gcgtccataa ttgaattaat tgaacctcca ggaataccat acaaatgatc tactccccaa
    16021 gcttctaaaa ctttaataac tgctgcacct gctagtatgt tagtttgttt tgtttgtttc
    16081 ataaccataa taaagccccc atttcatgca caatttaatt acgcacaatt taataaacga
    16141 atattaccat agcaaacgct tacattcaag tggtcataaa ctcatgcttt ttaccactta
    16201 atcacgattc aaacgcattg tagatcaaca acagcgctag tctgcttgcc ttgatgaacc
    16261 accatcgctg ttgacagtta gtatctcata cattcatttt ttaaacaatt ttagtaatta
    16321 gtgtatgttt tacaggggca tacttccaac aatgtctgca tgtttagaag ctagccattc
    16381 ttcgaaaact aactaccgct ttcaaaacat gaccttaact caactcgaca cagagcaaaa
    16441 taacatctgc caagttaatt attcagctat aatccgtacc acgctaccaa ctttaaaatc
    16501 aggataatcg ccctgctcaa catataacgt cccaggcaat ttagcctcct ttgcacccgt
    16561 aaaactaata gccgtatggc ctaatcttcc aaggttagtc tggacttcac caccaactgc
    16621 tgtaatttga tagacttgat tgtcgacttc aagtttcatt cctgctgtga tttgctcact
    16681 tattgggaca acttcgataa taaagcaaga aggccgtaat gcgtctggag cttcatcacc
    16741 aaataa
//
