LOCUS       gnlProkkaKCMKPCHI_33   16740 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCMKPCHI_33.
ACCESSION   gnlProkkaKCMKPCHI_33
VERSION     gnlProkkaKCMKPCHI_33
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 06:58:21
            Original ID  :: gnl|Prokka|KCMKPCHI_33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16740
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..81
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="MHSKTPEIVVQSRGFTSAIEKLDLFV"
     protocluster    1..16740
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6034:6740]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6035..6740
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16740
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16740
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(137..481)
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLYRKSVNWLSV
                     VMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAIFYFIKALEK
                     RHVFDRMRLR"
     CDS             complement(880..1014)
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MIKSILKFCLAATLIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             complement(1031..1276)
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             1562..3076
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MLAFKLCKSFLVIYVKRAIKMTEKLTTETGQPWANNEHSQTAGAR
                     GPVLMQDYNLLEKLAHFDRERIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKK
                     TPVILRFSQVAGEKGYPDTVRDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFI
                     HSQKRDPKTNRRTQNMQWDFWAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVN
                     QNGEQFWVKYHFISDQGVKNMTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQI
                     LPYEEGLNYKWDIFDVTKVISHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPG
                     IEPSPDKLLQGRLFSYKDAQRYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVN
                     YEPNALHGPEEVPDAALSPDSVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINT
                     IKDALGQVTLPGVKKLEIKQFYEADKNYGTRVANALGMNIADIISD"
     CDS             complement(3234..3671)
                     /locus_tag="ctg33_6"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(4027..4770)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(4763..6025)
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(6035..6163)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_9"
                     /sec_met_domain="TIGR04223 (E-value: 2e-08, bitscore: 25.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             complement(6144..6740)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="AgrB (E-value: 1.6e-35, bitscore: 113.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IETGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(7108..9222)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     962; E-value: 4.5e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEATKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(9613..9846)
                     /locus_tag="ctg33_12"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(10483..10839)
                     /locus_tag="ctg33_13"
                     /transl_table=11
                     /translation="MLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRVPTI
                     FDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQLAG
                     TKTIEDVKRAKLLR"
     CDS             complement(10852..11583)
                     /locus_tag="ctg33_14"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWNFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIIEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQ"
     CDS             complement(11610..13364)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 471.4;
                     E-value: 6.8e-143)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_15"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-41, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-32, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDH
                     LKYIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVG
                     QSATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVII
                     PDDLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQ
                     EVIAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNF
                     PFARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAA
                     QRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLN
                     KQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPV
                     INVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQ
                     KVTQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPA
                     LSQLLNEL"
     CDS             complement(13446..13871)
                     /locus_tag="ctg33_16"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             complement(14044..15855)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 494.2;
                     E-value: 8.6e-150)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_17"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-44, bitscore:
                     142.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-38, bitscore:
                     123.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLTPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSATSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
     CDS             complement(16226..16612)
                     /locus_tag="ctg33_18"
                     /transl_table=11
                     /translation="MYCMMTKERIIFSTKVLEIGAESADFKSIGMAVLFGDEAPDALRP
                     SCFIIEVVPISEQITAGMKLEVDNQVYQITAVGGEVQTNLGRLGHTAISFTGAKEAKLP
                     GTLYVEQGDYPDFKVGSVVRIIAE"
ORIGIN
        1 agtcatagta aaacccccga gattgttgtc caatctcggg ggttcacttc agcaatagaa
       61 aagttagact tatttgttta acgattgtag cgcgtttcat accgtgttca acctcttttt
      121 gtagcatcca tcgatattat ctaagcctca ttctatcaaa aacgtgtcgt ttttctaacg
      181 ccttaatgaa gtaaaaaata gcaatcacct gtaatggtat ctgaatgatg acgcgtgcca
      241 atcttcccaa caataacact ttaaaattag tgccaaatag cactgaaatt agccatgagt
      301 ccatcatcaa actaacaaaa atcattacaa gtatttgcgt catcacaacg gataaccaat
      361 tgactgattt acgatataaa aacaaaccgt caataaatcc ccctaaaaat gcagttaaca
      421 aaaaggcaat ctgaaacgcg ccggaaccaa aaatagtaaa gcttaatata tcggagatca
      481 tctccaagag accaccccaa atgggaccat atagataacc aatacaagcc atagacaaaa
      541 agccaaaaga taattgaaaa tacgctggtc cgatagcaat tttgtataaa ataacgtcta
      601 aggccaataa gaaagccgat gtagtcagca ctaataaatt catttttggc aactgaaaaa
      661 catttttcgc aataagttta gacataggcc aatcctcttt ttttgatttt aatcataccc
      721 tcattcttaa taaaagtaaa tattactttt attcgattga aggtagttta aaatcgtcgc
      781 tcttgattta gttccttgaa ctcaatgata ttactcatac taaaagccac taacaggtca
      841 actagtacac ccatcagtgg ctcattgtaa aattaatttt tatccatgta acttatcttg
      901 taatttatca cccaagttat caattccctt agcagtaagt acggtcccac caataagaac
      961 accacttacg attaaggttg cagctaaaca aaactttaaa atgcttttaa tcatcgcaat
     1021 catctcctta ctaatccatc cgtgtcagaa caaatgaggt tatcgcaaca acaatcacac
     1081 caccaataat tgaaggaaca attgccattc cggctaattg tggtccccat gatcccaaaa
     1141 gagcttcccc aattgcagat ccaaccaatc cggcaataat attactaatc caccccatcg
     1201 atttaccttt attagtaata gcacctgcaa ttgcaccaat aatagcacca atgatcaaaa
     1261 cccataacca atgcataaaa tccctcctag acttattaaa ccgcttaaat acaataatag
     1321 aattacacga atatttaagc cgattcataa atgattactt cttataatta tcattttaca
     1381 attatcgata atgatagaca aatataacac attatttaat aaatgggtcg ctactatttc
     1441 tcatgtgacg attccgggtg gcctagaaaa tatcaaacag cttgatagct gattaaaatt
     1501 aaactacgcc acatgaacga ttaacttaac tgtgcataat gattgaagtc actctgttaa
     1561 ggtgttagcg tttaaattgt gcaagagctt tcttgtaatt tacgtgaaaa gggcgattaa
     1621 aatgacggaa aaattaacga cggaaaccgg ccaaccatgg gctaacaatg aacattccca
     1681 aacggcagga gctcgtggtc ccgtattaat gcaagactat aatcttttgg aaaaactagc
     1741 ccattttgat cgtgaacgaa ttccagaacg ggtcgttcat gctaaggggg ccggagcaaa
     1801 aggttttttt gaacttgaaa acgacatggg ggaatatact aaggcagact tatttaatgg
     1861 tgtcggtaag aaaactcccg taatcttaag gttctcacaa gttgccggtg aaaaaggtta
     1921 tcctgacacc gttcgagacg tgcgcggttt tgccttaaaa ttttatactc agcaaggcaa
     1981 ttatgatctc gttggaaaca acacaccggt cttttttgta aacgaccctt taaaatttcc
     2041 tgacttcatc cattcacaaa aacgggatcc taaaacgaac cgtcgtacgc aaaatatgca
     2101 atgggatttt tgggctcatt ctccagaatc attgcaccag gtcacttatt taatgggcga
     2161 ccgaggtctt cctgcgtcct atcgaaccat gaatggttac ggttcccata cttttaaatg
     2221 ggttaatcag aatggcgaac agttttgggt taagtatcac ttcatctcag accaaggcgt
     2281 taaaaatatg actgctcaag cagctgaaaa agcaatgagc caagatttag attacttaca
     2341 agatgactta tatgatgcaa ttcaagaaaa aaattaccca tcatggacga tgtatgtcca
     2401 aatcttgcca tatgaggaag gtctaaacta taaatgggac atttttgatg tcactaaagt
     2461 catctcccac aaagactatc cactaattaa agtcggcaaa ctaactttaa atgagaatcc
     2521 cactaataac tttaccgata ttgaagaggc ggccatgtcg ccagcaaatt ttgttcctgg
     2581 tatcgaacca tctcccgaca aattactaca aggtcgccta ttctcctata aagatgcaca
     2641 gcgatatcgg ttaggtgcca actttgaaga tttacccgtg aacaagccgg ttgttccagt
     2701 tcataattat gaacgtgatg gttacatgaa aattaataat caaggtgctg aggtcaacta
     2761 cgagcctaat gcactgcatg ggccagaaga ggtgccggat gccgcacttt cacctgattc
     2821 tgttcgtggt gaaacacgcg cacagcctta tcgctatcaa gttgattaca caactcaagc
     2881 aggcgaccta tatcgcttaa tgtcagaacc cgagcaagaa cgcttaatta atactatcaa
     2941 agatgcgtta ggccaagtta ctttgcctgg tgtcaaaaaa ctcgaaatca agcaatttta
     3001 tgaggccgac aaaaactacg gtacacgcgt ggctaatgct ctgggaatga atattgctga
     3061 tattatcagt gattaatatt ttgaccggat gttatccagc gcgatattat ttttgttata
     3121 aagaatgatg atgccgtctc atggttatta actaaagagc gacaggttag actcatatcg
     3181 tgtaagtcta gcttgtcgct ctttaattaa caaaaaatct tagatatagc ttactactcg
     3241 accatccttt tattaataat gtgatcccct gtattaccat ctagacgact caacaatgca
     3301 ttgaacttta gtcgccgaac tggtcgtgga ataaattggc gaatatcatc ttcattaaag
     3361 ccaacttgaa ttttactatc actaatgatg ataggccgac gtaacaactt cggatgatca
     3421 cacaacaatt taagtgcctc attcaatggc atttcgggta acttaggcgc aatttcagga
     3481 tagtctttag atcgagctga gataatatcg tctacaccat gttcggttaa actcaaaata
     3541 cgttttagat cttgcaccgt gggcgaatca acactaaaat ttttctcctt gaactcaatc
     3601 ccatgtgctt ccaaccattg ccgtgcaact ctagaagaat gacagcttga ttgtgtatat
     3661 aacctaatca ttcctaatct gcccctctct cgttaaaatt catcacagcg tattgatcga
     3721 cattaacttc tgcctgtcac aacatccttt aaactaaacg cattcgttac tgtcatgacc
     3781 aatccaatac cccgtgaaca catctttatt ataggctctg aacaagggac ataccgaccg
     3841 ttttaagacg aataatctga ggataatcgt tttaagtaca cttttaaacg gtttaggaaa
     3901 gaacgaaccc agtacacgta atgctaacaa atatcactgc aatttctaat cgaataacgc
     3961 tgaattttca tcgcgtagca cataaaaagt cgcctactaa tttaacaggc gacttccttg
     4021 gaactattat gactttttag caagccattt agctagataa cgattagctt gtgcagaaca
     4081 aagcactttt tcaccatttg tcatggttaa tcgtcgcaag tgcttgtcca atgacttaat
     4141 gcgtttcaag ttaacaacat atgacttatg acacctatag aaattaggac tcaaatcagg
     4201 aacgtccttt aacagtccat agtattctaa ttcaccatca tccaaatgga ctacgatttt
     4261 atggggactg gttgaacttt caaaaaatat aatgctttta acattaattg atctgaccgt
     4321 ctcaccaatt tttatttgaa catagtcgtc ttggtcattt tcatcggttt gaaaacgatc
     4381 ttgcgccacg tgtaaaacct tgctaaatcg ctcatacaag gaatctggaa aatccttaag
     4441 aataaaatct aatgcctcaa cttgatattg aaacaccatc aaagataact ccgtgtgtgt
     4501 cgtgataaaa ataatcttgc tgcgacggcc catgtcacga atctggctag ctagttgaat
     4561 accattaata tctgaattaa gggcaatatc taacacatag attgcctttt gaggctgctg
     4621 tgcattaacc ttgtctaaca attcgtgggg atcttggcat gctaaacaga tactcatgtc
     4681 tagctgttga tcgacgatta ccttagtaat gatttgccgt atttgttgta attgtttcgg
     4741 atcatcttcg caaatgtaga cactaatcat tctgagatac tcgcttcacc gtcaagcgtt
     4801 gtaagaatac cgctcctaag actctggttt cgagtatcat gttctcattg cgattaacaa
     4861 tcttacttaa actattcaat ccaatccccc gattcttgcc cttagtggaa taacctgcct
     4921 ctttcagctt ccataagggt ggtaactgtt caaaaacatt gttttgaatc aagaacaccg
     4981 tactattttt ttcgataaaa atggcactca taatctctcc atcagcatgt cctaccgatg
     5041 cttcgattgc attatccaac ataatcccta atgcaatgtc taaatccaat tcattaacag
     5101 taatgtcaat taatggttcc tttaaatcaa aatgaacttc aatctcttgc gattgtgcat
     5161 agctcaactt actaaatagg atactcttaa tcgacttcac tttgacccga ctcaaatctt
     5221 caagattata tttttctttt aacacccgat ttgaaaccgg tgcaagattc ttttgataat
     5281 attcttgtaa accttctaaa tcatcagttt tcaaatattc atctatcgaa atcaacatat
     5341 tctgatagtc atgtctgaaa cgtcgcaact cattatagtg agcttcgatt tcattcatat
     5401 agcgagtatc attttgtatt tgtattcttt gcttttggac ttcatatttg gctcttacat
     5461 tttttaaata ttcgttataa atcaccaata ctaaccccat tacaactgac aatataatta
     5521 aattacttaa tataacctgg aactgatttt ccagaccttc actcaacata atatacaagt
     5581 atattatcat taataatagt gcggttatgc gatttaagct ctgattacta aacgtgggac
     5641 tgaaattcgt gcgatccatt acaatattaa gaaaaattaa gcttacgaca ctcaatatga
     5701 caaacactac cacataccca ttaggaactt tcattaaacg agttaatata tcacaaatat
     5761 ggtcaaccat aatcgaccat atgaacactt gaaatgttat acatagtgca ccgcttagaa
     5821 ctcgtacata ccaccaagtg aaaaatataa acatcattaa cattaaaaaa gaaaaactaa
     5881 ttcctaactt tgctaaaaaa atataactca tcagcataca gacggataag aatataacat
     5941 caaaaagtct cacaaaaaat atatttctca acaaagattt aattatcaaa tagatagata
     6001 attcttggaa gacaatcatt aacatatatc tacactaatc cttgcttttt aattcatcag
     6061 gaattttagt ttcgaataat atcccatggc agcacataac caactgttta gtacctacgt
     6121 attgaaaaag atggctaagt actttataca ttttttcttt cataattttc cctcctttca
     6181 tagggcatta gtaataaagc ggctaatgcc atcgcaatta aaatgattgt gccaaaataa
     6241 ttattactaa ctatttgtaa caaactcaaa attaatgaca atccaattgc ccgtcgcttt
     6301 aatttttttc tcaatgactt cgatgtaata ggattcttta ccgtatcagc tggagcaaaa
     6361 atacttatga ttattacaaa tattaaactt aataacaatc tgtatacttc agaaatacca
     6421 gtttcaatca catacggcac acccacaaac acaaagatag ttaatatcgt acataacaaa
     6481 tccgatttca agtgacgtcc ataggcaaag ccacgcaaaa ctaaaaaact acccataaaa
     6541 actaacactg ggaccaactc gtgtagcagc aacgctaaga taatagtaat tatcagctta
     6601 ggaataacat ttaatacagt atcaatgcct agtttaacta gtaatgcctg ccgtctttct
     6661 agttgaagat tcttttgaat cgcagcgaat aaccgatcgc ttaatttata aagcaatagt
     6721 ttttgttctg gcttttccat atcccactcc tataatgctc aaatacatac ctgtatcaac
     6781 agtttaaaac agtattaatt aattgaaaag aatacataaa tatattaatt attcaatatt
     6841 gttttaagac tagaaataaa catttaaaga tacatcagtt taattattca tacgaaacta
     6901 aagtttcatg taaaaagatc gttaatataa atcagtttca tcgatactcc cccttaattt
     6961 ttccttagat tacaagtcaa actagactta atttcactaa ttcacattac tcaatagatt
     7021 aatatcaaat ggtgaaaatc aacgaaaaga ggagatctat caagcaatct cctcttacat
     7081 aaagttattt atgaacactg atttaagcta agctgccgat atcacaatct cagcatccac
     7141 taaatcagcc ttcaagtttt tgacatctaa gtggtcaagg tagaaatccg ttaccttgtc
     7201 acgaatttgt tgttcaatta ctcgccgtaa tggccgcgca cccatcgctt catcatagcc
     7261 ttgttccatc agccaatctt tggccgcttt agttacctca agtttgatgg attttttggc
     7321 taacgttttt tgtacatccg ccaacatcaa atcgacaatt tgacttaagt cttgcttagt
     7381 cagatgtgaa aattccacga ttccattaaa acggttcaga aattctgggc ggaaaaatgg
     7441 tgctaactta tccattaatg actgatctcg ttgcttgtca ccacttaatg cttcattacc
     7501 aaagccagca ttagaagtag cgataataat cgtatttttg aaattaatga cattgccttg
     7561 tccatccgtt aagcgcccat catccatcac ttgtaacagt aacgttaata cttgtggatc
     7621 agccttttca atttcatcta ataatacaat ggaatatgga ttacgccgaa cccgttcggt
     7681 tagagtatta gcattatctt catagcctac gtatccagcc gaggtaccaa ttaatttcga
     7741 cacagctgta cgatcagcat attcactcat atctagccga ataatcgcat ttttatttcc
     7801 aaacatatct aaggctaatt gcttagctaa ttcagtcttt cctacgccag ttgggcccac
     7861 aaacagaaaa cttccaattg gctgatcacc ctctgaaaag cccgcacggt tacgccgaat
     7921 tgccttcgct accatttcaa ccgcttcatc ttgaccgatt accttacttt tcagacgctt
     7981 atcaagattt ttcaagtgct caatatcatt agcgcccata tcagcaactg gtataccagt
     8041 taaacgttca accgattgtg ccacatcatc aatcgtggca gtgatttttt ctttttgatc
     8101 cgttttttta attttttgct tggtttcctc gatcgacttc ttgatatcag cggcttttgt
     8161 aaagtcctcc gatttaacgg cggcctcctt agttgcctct aattttttaa cgcgttgatc
     8221 caatgtctca acatcagttt gcgaattttt agccgctaaa tgagccgcag tcatgtcgat
     8281 caaatcgata gctttatctg gcaaagtgcg ttgtggtata tattggattg aataatccac
     8341 agccgccttc aaaacatcat ctggtaatac aacatgatga tgcttttcgt acagcttttt
     8401 aacaccttgt aatatacgta aagtgtcagc ggccgtcggt tcattaatca caacatcatt
     8461 gaatcgccgt gccaaagccg catttttcaa aatagtattg cgatattcat cttgagtcgt
     8521 agccccgatt acagtcagct cgccacgtga caaagcaggt ttaatgatat cagccaatcc
     8581 tttgccacca tcttcaccac cagtggcgcc cgtgccgata atctgatgaa tttcatcgaa
     8641 gaatagaata atattaccag ctgctttaac ttcctttact agctgtttaa tattttcttc
     8701 aaaagaaccg cgatattgag ttcctgcttc caaagacgat aaatcaatcg aatagatttc
     8761 tttatcttga atcgtttctg gaactttacc agccacaatt gcttgtgcca gaccttcgac
     8821 gactgcagtt ttacctacac cagcatcacc aactaagatt ggattatttt tcgtcctacg
     8881 actcaaaatt tctgcagttt cttgaatctc attctcacgt ccaatcactg gatctagtaa
     8941 tccatcacga gcctgttccg tcaaattagt ccctaacttt tctaaaatcc cccctttttt
     9001 aacagcctgt ttaccatctt tagatacttc tattgtttta ttattttggg gtagcttacc
     9061 agttgctcgg tattgagcaa actcatccgg tgtcagcgat tgtccattaa ctaaataccg
     9121 tgcacgctcc gaattttgat tatccatgcg ccgaaataat tgattgaaaa catcatccat
     9181 atcattgttg aaaaaaggat catttccgta gaaatttgcc atattacaac acctccataa
     9241 aaatttatat gtgtaactta gtgaccataa tatcctttaa aactacaact gaatcgtatc
     9301 acgattttta tgtatcgtta agtaaagtgc ttatagaatc aattagaaat aattagaata
     9361 attttgttta aacaaaagag aaatcaattt cataaaatga attgatttcc ctacaaggtt
     9421 ccctatttaa tagcccttga taaagaactt gaattaacaa gttactttcc agaccaattt
     9481 taatttaaga gactgcgact caaaaagcac acccagtatc aagttaaggc caactagtta
     9541 tcgttaatat tgccacttaa atatcaatac tagcaatcat gatacacgtg taaaatcata
     9601 aaccaaaaca tattacatga cgtaacggcg gtcttgggac tgtaaactca cagtaatgat
     9661 tctattgagt tggataaggt gccgatgacc agtaattgcc ataaatgcaa ttgctttcgg
     9721 tacaatcgta gtgacatagc caactgtctc ggccatctgc ccatttgttt tataaaaccg
     9781 taatgagact cgacattttt gatcatgcgc ttgttgtaat ttacaataat tattttcaac
     9841 actcaaatta aagtctcccg ttcaaagaat tcaggtttat ttattcgtca gtgaatctat
     9901 gtgtttgttt ttctcattgt tgacggcgta agtccacatt aaggagtcag ctattcagta
     9961 aaaactaaat aactagtatt catgttcagc tcagtataat atgcattgat ggttactaat
    10021 caaaaatcga tctctaaata tcctaattac tatgaaactt tgaagttaat ttatgagaaa
    10081 aataactcac aacaaaactc atgattacaa ccttgtcatc ataactagat tatgaaacat
    10141 tcagcctcct aaataaaact ggtatgcgcg catgtgcgca tgtgtacagt atactattgc
    10201 caggtatgtc tgaataaccg ttttaagact tgaaaaactc agctgggtgc tttaggacgc
    10261 tttttgtgca ttttaagaca atatcctaac ttcaacgccg gcatagcttc aattcgtcaa
    10321 tcagtgtctt agttcctcag ctatttctgt tcagaacatc ttcctattac aataaaaagc
    10381 gttgatctca gcagaattta cttccaccaa aaccaacgct aaagtgttat tatatcaggt
    10441 attttaaatt catttcagac attatattca gcattacttc tactacctaa gtaatttagc
    10501 acgtttaaca tcttcaatcg tcttagttcc cgctagttgc atatcgatca acagctcatc
    10561 attaaggtga ctcactacgg aagcgacacc ctgcgcacca cccaatgcta atccatagat
    10621 aatcggccga gcaagtgcca ccagatctgc accattggct aacgccttaa agacatggga
    10681 gccacgccga acaccgctat caaaaattgt tgggacgcgc ccattaacgg cttgcgcaat
    10741 ctcgtgtaaa acatcaaagg aagctggacc accatttaat tgccgaccgc catggtttga
    10801 aacatagata ccttgagcac cagccccgat tgctaacaag gcatcttctg gttactgaat
    10861 ccccttcaca ataactggta aattcgtata ttctgtaata cgccgaacat cagctgggct
    10921 aatcttttgc gccgcagcag catagatttc tatgatacct ttccctttac catccccttc
    10981 gctgaactta gtcaagttag ccattgggat tggaaactgg aaattgttga taatatcagc
    11041 ttcacgatac ccgtcaactg ttgcatcaac agtcaaaatg attgccttag caccagcctt
    11101 cactgcttca tccaataaac tctgattgaa attccaatcc ttgctcatat ataattggaa
    11161 aaattggggc gcacctttac cagctgcggc agtatccgca attgacgttg aagaataagt
    11221 actctgagcc atgagtgccc caacttgagc catcccttca gcagtcgcag cttcaccccg
    11281 tgcatgtgcc aatccttgag cggccgctgg agccatcata ataggcgttt tgagatctat
    11341 gccaaaagcc tgagtctgtg tgcttggctg ttccatatcc gtcaatgctc gtggcacaat
    11401 ttgaacatgg ttaaaggcca ttgtattctg ctttaaagtc cattcgtctt ctgacccacc
    11461 actaatatag ccaaagcctc cgctcgggat gatcttttta gcagctgctt ccaatgatgg
    11521 taaatttaaa atcgttaact tttgctcacg atcactctgt tcatatccat taataactgt
    11581 cattatacta atctccttta cataaccctt tataattcat ttaataattg gctaagtgcc
    11641 ggttgatccg cttcagcgat accatatcgt tcacgatact tagcaatcgt atctgcatca
    11701 aagttttctg gatctactgg aacaaaacta gtatcaattg gatcaacatt tttaattttt
    11761 gcatcaatca caattggtag ttgattacca ttctgctgta gttgagtaac tttctgaaac
    11821 gttgctttca actctttaag gttagtcact ttaaaaccaa tcgcacccat gttgtctgcc
    11881 atcttggccc aatcagcacc aatcaagtca atcccatacg gcgcctgatt agcgagtaac
    11941 ttttcatgtt gaataaagcc taatactttg ttttctaaaa ccacgttaat gactggcaaa
    12001 tgatatttaa cttccgttag taagtctggc atcaccatgg cataaccacc atcaccagaa
    12061 atactccaaa cctgcttctt aggataattc aattgggcgg ccaaacctgc tggcaaacca
    12121 aaacccatcg tgccatacca agccgacatc gtaaaagtct gttgcttatt caatggtaac
    12181 tgtcggattg cccattccgt attattccca acatccagac caaagacggc atcatcagta
    12241 gcattgtctt taatagcttc tagcacccct tcagccgtca accctccttg atcatcagta
    12301 gcaattgtct tgagccaccg gttccagttt tgcttatcac gttgagcagc tttcaagaac
    12361 ttagttggct taattgtcac ttcggattga agtaatgctt ggaaaaattc ttttgcatct
    12421 gcaagaacag taatatcagc atcatgttgt ttgcctaaat ctgctaaatt attattgact
    12481 tgaataaact taattccttg tggcaagtaa cgtgcaaatg gaaagttagt accaacaaac
    12541 aaaactagat ctgccgcttg cgagacttca aaggcgggtt tagttcctag tcgaccgcga
    12601 gagcccatga aattaggatg gtcagttggc ataataccag ttgctggagc cgtcgacaaa
    12661 accggcaaac taaatttttc agaaactgcg ataacttctt gacgcgcatt ataggcaccc
    12721 ttgccaatcc ataaaacagg gtgttgagca gctttcaaag ccgctatcgt ctgctgaacg
    12781 tcatctaatt tcggcattaa gacctgttga ctgccgctaa gtgaagccgt tttaaaacca
    12841 tcaaactcaa tatcttgacc agacaaatca tctggaataa taacaacaga aaccgaacgg
    12901 gtcgcgtatg ctgatctaat tgcttcatca accacgtatg gaatctgttc agccgttgtc
    12961 acttgtttat gaaattcggc tacatctgca aaaattggat cttggttcat ttcttgaaag
    13021 aagttcgtat tcataatgga tgttgctgat tgaccgacta aagctagcac cggtacgtga
    13081 tccatcttgg catcgtataa tccgttcaag agatgaacgg cgcccggtcc tgctgaacca
    13141 aagctaacac caatcgtccc agttaattta gcatctgccg cggcagctaa agcaccaact
    13201 tcttcatgac gtacttgaat atacttcaag tggtctttct cttggtagaa cccatctacc
    13261 gtgttattaa tcgagtcagc tgtaatacca tagatatgat caatgttcca gtcgactaac
    13321 acttgtgcca atgcttgtcc tgctttaatt ttagtcattt ccattaccct ctttttgttg
    13381 ttactttttt gagcacaact atatcctaaa taaaaacttg acccttgtca agtctttatc
    13441 ttaaattatg cttgttgttg aacagcgcta atgtcatcaa taatatcttg cagcgtcact
    13501 cgcgacatac gtgcctcagc actattctga atatcacaat agtatttttc catcactcgc
    13561 ggaattaccg acccgaccgg acacgtctcc gaagtattat gatcaacgtt taaaaaatta
    13621 cgcttagcca ccactgctac atagatatct ttcaaggtaa tatcattggg cgaacaagct
    13681 aatgttggtc tagcaacgcc acgaaccgaa gttaacaagc ctgcttttct taacttactc
    13741 atcattcttc tgaccatggt aggatccgta tttaaactac tagcaatatg ctcacttttc
    13801 agctggtcat cagtatgcaa cgcaatatat gccataatat gcgtcgcatc acttaattgt
    13861 gtattagcca tctagacacc tcccatatcc atctctattg ttacttattt tagcacatct
    13921 aacatgaaca taaaagcgat taaggaaata agttaggctt ctttccctaa tcgcaacata
    13981 agattatttg ataatctcca ttaattcaat caaacttatt caagacatcg atagtagctg
    14041 aatttaaaac ccaccctgtc caatttgatg ttgcaaatca tctaagccaa attgttttaa
    14101 ataagttgaa agtggttgta aatcttgagc ttcataccgt tgtttaaatg cttcaatatc
    14161 agctgccgaa ctcgttgccg aatctaaacg aagcttttca gcaggcagtg gccgatctcc
    14221 tgtaatcacc gcatcaatca gaactggttc atgctgagcg attgctttgg cttgttcaaa
    14281 aacatcaggt aattgctcaa tcttattaac tcgaaaagct tgcatgtgca cgccatcggc
    14341 aatcttacta aaatcaatat cattgaattc aacgccaata aaatcattct gattagtatc
    14401 ttcctgctca tctttgataa atccatattg gcagttggtg aaaacaacat taatcactgg
    14461 taaatggtat tgaacttgcg tcgccaaatc ttgcatggtc atcgaagcgc caccatcacc
    14521 ggccagatta aacacctgcc gctcaggata attaagtttg gcagcaattg ctcccggaat
    14581 accaactccc atcgtagcaa ataagttaga agtaatgtgc cgattggacg gcgttaattt
    14641 caaatgtcga ttcgcattca aattgatatc accaacatca atcgaataga ttgcatcagg
    14701 ctccgcaatt ttattaaccg cacgtagcac ttgatatgct tgtaaaggcc cttcctgctt
    14761 atcttctaat gaagctagat aagcccgcca atttttaaca ttggctaaat tggcttgcca
    14821 ccaaggtgtc gactcccgtt cagatacctg tgctaaaatt gcagccagcg ttttttgtgc
    14881 atcagcaagt accgcaatat ctgttttatg tcgtttacct aacttagctg gatcaatatc
    14941 aatttgtaag aaataacgcg tatttttaaa cgctttggaa acttctgcaa acggataatt
    15001 attaccaaca aataaaacaa cgtcggcttg cgcaagtgcc tcattcgccg gtttttgtgc
    15061 cacccgatta gcagaaccca aataggctgg ataacgatcc gcgacaatac ccttagctgg
    15121 atacgtactc attaatggaa ttttcaacgt tttactcaat tgttcgagtt ctttaccagc
    15181 cttacgagct ccaatgccat agtaaataag tggccgttca gctgcgagta aagtctgtgt
    15241 caatctcgtc actgcttgaa cgtcgggttc tggtaataac ggcgtttgat aactattagc
    15301 ggaagcatac caatcttcag ctggaatctg ttgccatggt aaatcgactg gaatttgcac
    15361 aaccgcaaca ccttggtgcg cgtaggcgcg tcgaattgct tcgtcaataa catgtggcaa
    15421 cgtggcagca ttgacggctg ttacattata atctgcaacg tccgcataaa tcggattctc
    15481 attcatttct tggaacgtat ccatgttcat cccagtagtt ccaaattgac caataagtgc
    15541 tagaacaggg acatggtctt cacgcgcatc atataaccca ttcataagat gagtgccacc
    15601 aggtcccgct gagccgaagc aaaccccgat tttacccgtt agcttagcat cagcagcggc
    15661 ggccattgca ccaacttctt catgccgtac ttgaatataa tggattcgat ccctttctgc
    15721 tgataatgcg tccataattg aattaattga acctccagga ataccataca aatgatctac
    15781 tccccaagct tctaaaactt taataactgc tgcacctgct agtatgttag tttgttttgt
    15841 ttgtttcata accataataa agcccccatt tcatgcacaa tttaattacg cacaatttaa
    15901 taaacgaata ttaccatagc aaacgcttac attcaagtgg tcataaactc atgcttttta
    15961 ccacttaatc acgattcaaa cgcattgtag atcaacaaca gcgctagtct gcttgccttg
    16021 atgaaccacc atcgctgttg acagttagta tctcatacat tcatttttta aacaatttta
    16081 gtaattagtg tatgttttac aggggcatac ttccaacaat gtctgcatgt ttagaagcta
    16141 gccattcttc gaaaactaac taccgctttc aaaacatgac cttaactcaa ctcgacacag
    16201 agcaaaataa catctgccaa gttaattatt cagctataat ccgtaccacg ctaccaactt
    16261 taaaatcagg ataatcgccc tgctcaacat ataacgtccc aggcaattta gcctcctttg
    16321 cacccgtaaa actaatagcc gtatggccta atcttccaag gttagtctgg acttcaccac
    16381 caactgctgt aatttgatag acttgattgt cgacttcaag tttcattcct gctgtgattt
    16441 gctcacttat tgggacaact tcgataataa agcaagaagg ccgtaatgcg tctggagctt
    16501 catcaccaaa taatactgcc atgccaatcg atttaaaatc agcagattcc gcacctattt
    16561 ctaagacctt tgttgaaaag ataattctct cttttgtcat catacaatac acctcaaacc
    16621 ttctaaaaat ttattttgaa tataatccaa aacttgcaat ccaagcaata aagacccgcg
    16681 gaacgccgtt gataaaccga ctatataaca ctgatggcac cccaacttca accgtcttag
//
