LOCUS       gnlProkkaPCLAGGJO_174  11156 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PCLAGGJO_174.
ACCESSION   gnlProkkaPCLAGGJO_174
VERSION     gnlProkkaPCLAGGJO_174
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 21:27:53
            Original ID  :: gnl|Prokka|PCLAGGJO_174
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11156
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11156
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1842:6156]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1843..6156
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11156
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11156
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..616
                     /locus_tag="ctg124_1"
                     /transl_table=11
                     /translation="MEERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKKRMGDVIRLM
                     SRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIPKNTNTVTIN
                     GAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPG
                     CEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             631..1779
                     /locus_tag="ctg124_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1843..2562
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 57.2; E-value:
                     2.5e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg124_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.4e-17, bitscore:
                     52.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRLGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2583..3884
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg124_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3901..5025
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg124_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5035..6156
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg124_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg124_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5125..6132
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg124_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg124_6_Aminotran_5.1"
                     /locus_tag="ctg124_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6153..6626
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6623..8068
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             8068..8790
                     /locus_tag="ctg124_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8804..9814
                     /locus_tag="ctg124_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRXXXXSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGGK
                     YTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYYC
                     LLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9819..10778
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 ccgtgaggaa cgtctttccg atctggtgaa taaagcgggt ggtcctacca gtcttgccta
       61 tctccgtggt gcgaaattga cccgtgtggc aagtgcgggt gagaagaaac gtatgggtga
      121 tgtgattcgc ctgatgagca ggcaattggg tgaagccatg attgactctt tgggtattgg
      181 tgttgaggat acctttacgg taggcattga tctggagaag gctttgacta atcctaaggg
      241 tagtgccgac cttgtcctac gtgaaggtga tgtggtcttt atacctaaga atactaatac
      301 tgtaactatc aatggtgctg ttatggtccc caatacggtt tcttatatga agggaaagga
      361 tgtggattat tacctgaatc aggccggtgg ctattctgat aatgcaagga agagtaagaa
      421 gttcattgtt tacatgaatg gtcaggtgac gaaggttaag ggtagtggta agaaacagat
      481 tgagccgggg tgtgagatta ttgtgcctgg taaggctaag aagaaaggga acatagctaa
      541 tattttaggt tatgctactt ccttcagttc tttgggtatg atgattgctt ctattgctaa
      601 tcttataaag aaataataga atttactttt atgtcagaac aacgacagga taaaaacttg
      661 ctctctgaac cacacaagac agaaagtgat gagatagaaa ttgatttggt cgatatcttt
      721 cgcaagatta ttgctattcg taaaaaatta tacaaagccg ttggaattgg ttttattatt
      781 ggaataattg tagcggtaag tatccctaaa cagtatacag taaaggttac cctttctcct
      841 gaaatgggta atgcgaaggg gagtaatggt ttagccggac ttgctgcctc gtttttagga
      901 gatggggctc taatagggga aagcacagat gccttgaacg cttctctttc agcagatatt
      961 gtttcttcaa ctcctttttt attggaactt ttagaaatgg aagtctccgt ttctaaaaag
     1021 gatgataaaa tgactttggg gtcttatctc gatgaagagt catctccttg gtgggattat
     1081 cttataggtt ttccgggcat agtaatagga ggagttaaat cattattcgg agaagatacg
     1141 gttcctgcca gtggagggcg gcaaggaact atcgaattga cgaaagaagt aaatgagaag
     1201 attaattttc ttaaaaagaa gattagtgca tccattgata agaaaaccgc cataacgagc
     1261 attacggtca ccttacaaaa tccgcagatc actgcggtta tagcagattc tgtcgttcat
     1321 aaattacagg aatatattat tgggtatcga acttcaaaag taaaagaaga ctgtgcgtat
     1381 ttggaacggt tgtttaaaga acgtcagcag gaatattatg ctgctcaaag aaaatatgcg
     1441 gattatgtag acgcccatga taatgtggtt cttcaaagtg tacgtgctga gcaggagcgt
     1501 ttacagaacg acatgagttt ggcttatcag atatatagtc aggttgctaa tcagttgcag
     1561 gtatccagag ccaaagtaca ggaggaaaag ccagtctttg cagtagttga gcctgccgtt
     1621 gtacctttga aaccttcagg tatgggactc aaaatttata ttttattatt tgtgttcctg
     1681 tccgtatctg gtactctcgt gtgggtgctt tttggcaaaa gtctgctggc tagcttgaga
     1741 aaagaactga aaaataagga gatagaacag gataaatgat gctaaaacgt cgtttacaac
     1801 attcttatat caattaaatt cacttactat attattaaac gaatgatacg tacagctatg
     1861 ataatggctg cgggcatggg aacccgtttg ggccaatata cagaattgat acctaaaggg
     1921 ttcgtcaaag tgggaggtat tccaatgata gttcgttcta ttgatacttt gttatcatgt
     1981 ggcattgagc gaattgtaat cggtacagga tataaacaag aagtttatga agaattgaag
     2041 acagactatc ctatgcttga aacctgtttt agtcctcgtt atgctgaaac aaatagtatg
     2101 tatactttat ataatacgcg ggagattctg ggcaatgatg attttttatt gttagagtca
     2161 gatttgattt ttgagaaaca agcaataatg agcttattgg agtgtcctgc ggcagatgca
     2221 atgctaatag ctccagtgac aaagtttcaa gatcagtatt atgtggaaca tgatgataat
     2281 tttcgccttt cttcatgttc tgtcaataag aataaactaa acgctaaagg cgaattggtc
     2341 ggcatccata aactatccgg ttccttttac aaaataatgt gtgctgatta tgcgagtatt
     2401 gttgatgaac aacccaattt gggatatgag tatgaattac tacgaatatc ttgttctcaa
     2461 tctcctgttt atgtgcataa agtagaaggg ctgaaatggt atgaaatcga tgacatatca
     2521 gatttggaat atgcagagaa atatattgtt ccgtattgtt aattaaaata atatatcaaa
     2581 ttatgagtaa gacagtttat attgggatga ctgcggatat tatgcatcca ggacttatcc
     2641 gcattattaa tgaggctact aaatacggtg atgttataat tggtcttctt acagataaag
     2701 ctattgcgga gcataaacgc cttccttatc tgacctatga acaacgaaaa gaggtagttc
     2761 agaatattaa aggcgtatgt aaagttgttc ctcaagaaga atggagctat gttgagaatc
     2821 tcaaacgcat taaacctgac tatataattc atggtgacga ctggaaaacc gggcctttac
     2881 gtgaagaacg tgtgcgcgta tttgaagtga tgaatgaaca gggaggaaag gttatcgaaa
     2941 ttccatatac tttgggaatt aattcatctt ctttggataa agatattaag gctataggta
     3001 caacccccga tgtacgttta aaatcacttc gtcgtttgat aaatgccaaa cccgtagttc
     3061 gtattttgga agctcatgat ggactatgtg gcttgataat tgaaaatcag gaaatattaa
     3121 aaggggataa gagggaagta tttgacggaa tgtggtctag tagccttacg gattcaacca
     3181 gtaaaggtaa acctgatatt gaggcggttg atttaactac ccgattgcaa gatttgaata
     3241 atattctgga gtgtactact aaacctatta tttttgatgg agatacaggt ggtaaaattg
     3301 aacatttcgt atttacagta cgcactttag aacgtcatgg aatctcagct ataataattg
     3361 aagataaagt tggattaaaa aagaattcat tgtttggtac ggatgttatt caaactcaag
     3421 atacaatcga aggtttctgt aataagatca aagcaggaaa ggcatctcag attactgatg
     3481 attttatgat tatcgctcgt attgagagcc ttatagcggg aaagccggta agtgatgctt
     3541 tagagagagc ttttgcatat gtccaagcgg gagcggacgg tattatgata catagcaaaa
     3601 ataagtcggg tgaagatata aaagaatttt gtttggcgtt tcgaaaacag tatgctcatg
     3661 tacctatcgt ggttgtgcct actacatatg atcatattta tgagtctgaa ttgtgtgatt
     3721 ggggtgtgaa tataattatt tatgctaatc atatgcttcg tgccgcttat cctgctatga
     3781 tgaatgtcgc aaagacaata ttagagaatg aacgtgcttt agaggtgcgc gaactgtgta
     3841 tgcccataaa ggaaatattg gaactgattc cgggtactaa ataaaaagag gaatatcatt
     3901 atgttaagcg tagaaaaagt ttatgaaacg tttctgagtc atgacgttga tttttttaca
     3961 ggagttccag actcattact aaaaaatatt tgtgcctata tcacagacca tacttcacgt
     4021 gagaaacata tcatagctgc taatgaaggt gcggctgtag gaattgcttc aggttattat
     4081 atggcatcag gtaaggttcc tgtggtttat atgcaaaatt ccggcttggg taatactgtt
     4141 aatcctctgc tgtctcttgc agatgaacaa gtatacagtt ttccaatgct tttgatgatt
     4201 ggctggcgtg gtgaaccggg aacaaaagat gaacctcagc ataaaaaaca gggtgaggta
     4261 actttagatt tgttgaaagc aatgcggatt ccttatataa ttcttgattc aaatgagaat
     4321 gatgcattta ttcagctcca tgatatcata caatcagcaa aaactaagaa tattcctcat
     4381 gcaataatta ttcggaaaga tgtttttggc aaatataaac ttcaaaaaga gttcggatgt
     4441 aattatcctt tatctcgtga ggatgctttg caaatagttg tggattatct gcctgaaaat
     4501 tcagtggtcg tttctactac tggcaagctt tctcgtgagt tatttgaata tcgagaaatg
     4561 aaagagcaag gtcatgaaca tgattttctc acggtaggct ctatgggaca tagttcatca
     4621 atctctttgg gtattgctat agcaaagcaa gatagacctg tttattgctt ggatggtgat
     4681 ggagcattta ttatgcattt aggggcaatt agtaacattg gcgatttatc tcctaaaaac
     4741 tattatcata ttttgtttaa caatggtgct cacgagtctg taggaggaca gcctacttta
     4801 ggatttagtt tagatattcc ggctattgtc cgggggagcg gatataagca tacttatact
     4861 gtttgtacaa aagttgaaat tgaagaagca atgaagcagc ttccaaagtt atgtggtcct
     4921 gttttgttgg aaataaaggt taaaatagat tctcgggaga atttgggacg tcccacgact
     4981 actcctatag agaataagga gcattttatg gattttttaa aataaatata ttcgatgaaa
     5041 atagaaagaa aaatattatt aaatcctggg cctgccacta ctactgacag tgtaaaaatg
     5101 gcacaagttg ttccggatat ttgtcctcgc gagaaagaat tcgcaggtat gatgaaacaa
     5161 cttcgggacg atttggtcag agttgctcat gggaatttgg aaaaacatac cgctgtatta
     5221 ttttgtggct caggaaccat caatattgat atatgtctaa attctcttct tcctgaagac
     5281 aaaagggtgc ttatagtgaa taatggggca tatagtaccc gtgctgtaga agtgtgtcaa
     5341 tattatggtt tgcctcatat taatttggaa ttttccgttt acgaacgtcc tgatttatcg
     5401 gtggtggaaa atgtgttgca agaaaatcct gatatagcta tggtttatac tactcatcac
     5461 gagacgggta caggaattct gaaccctatt cgcgagatgg gcgctatagc tcataaatat
     5521 caggctaaat ttgtcgtcga tactacttct tctttgggca tgattccttt tgatatagag
     5581 aaagataatg tggatttttg tatggcatct gctcaaaaag gacttcaagc gatgacaggt
     5641 ctttctttta ttataggcaa tgaggaacag attaagtttt caaaaaaata tcccaagcgt
     5701 tcttactatt gtaatcttta tttgcagtat gagaattttg agagaacagg tgaaatgcat
     5761 tttactccac cggtacaaac tatttacgcc actcgtcagg cattaaatga atattttgaa
     5821 gtgggcgaag aagctaagtt tgcccgtcac aaaagagttt ttgaggctat tcattcaggt
     5881 ataaatgaaa ttggtcttaa aagtgtaata aagcgtgaat ggcagtcagg actggttgtc
     5941 tcagttcaat acccagaaga tcccaactgg gattttgaga aaatacatga ttattgttat
     6001 gagcgtggat ttacgattta tccaggtaag atatcaactg aggatacttt tagaatctgt
     6061 gctttaggag agatagaagt agatgatatt gagaacttct ttaaagtact aaaagctgca
     6121 ttaaatcatt ataacgtcac attaccgatg tcatgattgc agaaatatta ttgaagattc
     6181 gtcattttta tttttccctt cgtggtatac acttccatcc ggaaagtgtt atttctggag
     6241 tgcctattcg tagctttcgc ttagtaggca aatatagcaa tatctactta ggtaaaaatg
     6301 ctgaaatacg ttcaggctgt tatctgattg ctcgtgataa aatcattatt ggagaaaact
     6361 caacactcgc ctatggaacg actatattga caactgctga tcctaatgga ccgtataatg
     6421 cattagcagt tctttatcct tataaaaagg caccggtagt tataggagat aatgtttgga
     6481 ttggggctaa tgttaccatc cttcctggag taactattgg tgattacgtt gtagtagcag
     6541 ctggagctgt tgtaacaaaa gatgtacctt caggagtatt ggtagctggt gtaccagcta
     6601 ttgtgaaaaa acgttttaat aaatgaaaga aaaaacttct ttaaagaaca aagccatatg
     6661 tggaatcttt tggagtgcag ttgaacgatt tttatcacag gggatacagt ttgtagttac
     6721 agtcattatg gcgcgttttc tattgccatc tgattatgga atggtaggaa tgttagcaat
     6781 agttcttcaa ttatctcaaa cgttaatgga tagtggtttt actaatgccc ttattcgtta
     6841 taaggaacgt actgaaattg attattcaac agttttcttt tttaatatat tagcatcatt
     6901 agttatttat tttctaattt tttttctagc tccttatata tcgtggtttt ataaaatagg
     6961 tcaattagtt gagattacta gaattttatc tattgttatt gttttaaatt cctttgcgat
     7021 tattcctaaa actaaattaa taatagctgt agattttaaa actcaatcaa aagtctcatt
     7081 tattgcagct ttggtttcag gtattattgg catttgggct gcatatttag attttggagt
     7141 ttgggcttta gttggacaaa ctttagtaaa cggattgttg attgtagttt tgtatgcata
     7201 tttttgtaga tggaaaccat tgtggatatt ttcattgaaa tcgtttcgtt tattatttgc
     7261 ttttgggtca aaattagtat tagctaatat tcttaatact ttatataaaa atctgtatgc
     7321 tatagttata ggaaagaagt tttcgtcggt tgatttagga ttttatactc gtgcggaaca
     7381 atttgctcag tttccttcat ataatttgag tgcaataatt tctagagtga cataccccat
     7441 attgagcctt gtgcaaaatg ataatgatag attatctgct ttatatagga aatatgtccg
     7501 tttatcttct gcttttatct ttccattgat gattttgtta attgtcatag ctcagccact
     7561 ggtattattg cttttgacag aaaaatggat aggagtagtt gtattgcttc aaatattgtg
     7621 tttagattgg atgtttgatc atttgagtag tataaatttg aatttactat atgtaaaggg
     7681 acgttcagac ttggctttac gtttagaagt tataaaaaaa gtgttagcga cggggatcct
     7741 tcttctatct attccttggg ggattgtagg tatgtgttgg gggcgtgtta tgtattcatt
     7801 gattgctgtg tatttgaata cttattatac agaatcattg attaaattaa gtcttattag
     7861 acagatgaga gatatactac caagcttttt tttagcatta ataatgggag gaggtacttg
     7921 gtatatgatt ttattgttag agggtgaaat tgttcaaatt gtagtaggaa gtgttattgc
     7981 tttattgcta tatggaacgt tgttgtattg cttttctcga tccttgtttg atgaaatatg
     8041 ggcggttata ttaaaaataa aaaggtaatg gataaactga gtttgattat tagtaaaata
     8101 cgacggaatc attggtatag aacctatatg cgtcctatat atttatttgt ttatggcaat
     8161 agaaaattga agaatagaaa tagaatattt ttgcagtatt cacaagagct gctaactaac
     8221 tttcatcaag caatgaatga agtgggaatt ccttattggt tagaatttgg aactctttta
     8281 ggtgctgtta gagaacacag ttttataagt catgattttg atcttgatgt gggccttttt
     8341 aaggaagatt attcagatat aataagagag gtcttaaaaa aatatggttt caaaagaata
     8401 aggtgtataa ccgcccttga ttttattgat gcttatgagg aaacttatct ttataaaggt
     8461 gtgacaattg atcttttcct tttttcaaga gagaaaaatt gtgatggggt ctattgttat
     8521 gattttgttc cagtatattc agatataaag agaactaaaa aaggtgataa tgcaatccgg
     8581 agaattcatt ttcctagaat tgatttgatt gaatattcat ttattggaat taatactttt
     8641 gttcctgaaa attatgagga acatctttgt atgcattatg gtaaagacta tatgattcca
     8701 aatcctcatt ggaaagattc agatgcgcaa catactgata tcttttatgg tagagagatt
     8761 agaattgaat tgtttgataa aagtaaataa tagtagataa tacatgttct atctattttt
     8821 tttactaatt gtgctatttt tgttatatat acaaagtagg aaaagacaat attctactgt
     8881 agcgggaatt tgtgttccta ttattataat ttttgttgta atttgtcgtt atagagtggg
     8941 gtatgactat ttaacgtatt atacattaat tgaaaatgaa gaagaggcac agattttata
     9001 cttattttct cctttaagca ttgtttgggc agagattgct ttatattttg aatctccaca
     9061 gatgttattt gttctttttg ggcttccaac atttgctctt ctaatattta ctttaaaaaa
     9121 atattcaaaa gattatgcgt tatcagtaac tattttaatt tgtttcttct tttttacatc
     9181 actcagtatt attcgacaag ctttggcttt ggctatttgt ttttatggtt atcgttttat
     9241 agtaaaacgt tcactaatta aatatatatt atgtatattg attgcagctt tattccatcc
     9301 ttctgcagga gtagcgatta ttatatattg gttgccattt ctaaagttta gattnnnnnn
     9361 nnnntctata atatcaatag tagccaaacc tttatttttt tatatgctaa atatattagg
     9421 ggtgtatacc tcttatcttg atggcaagat ggatattgaa ggtgggaaat atactcaatt
     9481 aatatacttt ttgttgttta ttatttgttt tgttttggga agtaaaaaca tagataaaaa
     9541 caagtgtaat ttatttaatg ttttattgtt aagttttgtt ttcgtatctt ttttaggagc
     9601 tcatttaggc gggagaatag cgttttattt taatatatat tattgtttgt tgattcctaa
     9661 agtggttaaa ggattggatg ggcaactaag agagcaagtg aagcttcttt cttattttct
     9721 atgtatttct tatttcttat tgtacctatt cgttccattc ataaaaggtg taccctcata
     9781 ttatatccca tataagttta tatttttcaa atagtaaaat gttgatatct ataattgtcc
     9841 cttgttataa ttctgaaaga tatttgtctg attgtttatt gtctatattg aatcaaacct
     9901 atgttaattg ggaggtgatt tgtatagatg atggaagtca agataataca ttatctattt
     9961 taaatcatta cgctacattg gatgagcgtt ttaaaattat ttctcagtct aatgcaggag
    10021 tgtctgtcgc aagaaataag gctctatccc agtgtcaagg agagtatatt tgctttgttg
    10081 atagtgatga cctgatagaa cctaattttt tgataacact tttacagctt ataagtcatc
    10141 aggctgattt ggcaatctgt ggttttactc gttctatggt tttctgtatg gatgatgctc
    10201 aaggatatat agaaatgagt ggtaaacgtt gtatagaaag aattattcta gataaaagtt
    10261 tcaatcctca gatttgttgt atgttatttc gacataatat tataaaagag aaacaattag
    10321 aatttgtgat agggtgtact cgtggtgaag atcgtgaatt tatattgaaa tatttagttt
    10381 attctaataa ggtttgttat acaaacaatc ttctttatca ctatcgtgta aatgatcagt
    10441 cagccatggc aatcttttct attaaaagtt tgacaagtat agaagcttca caacgcacgg
    10501 tcaactacta taaaaaagtg aattattctg ttagagggct tgaatttgaa ttttcacgta
    10561 cattgtggaa attcatgatt ttagctattt tgtctgggca aaatgattta tatcaaatca
    10621 ttcgagaaaa gtatgatcta aaaagacaaa tggaacatct ttattctcat ccaggactat
    10681 ccgaaaaact tacagcgaga ttgtttgttt ggaatgaggc actttttaaa tgggtatttt
    10741 ctattattag atatctatat aaaaaaagat ggagatgaat aaacgaaata gattatctga
    10801 acaagaaata aaaaaagtag aacttgacgc tttattgtat attcggaaaa tttgtcagca
    10861 atatcatctt cgctattatt tagcttgggg tactttgttg ggagccgtta ggcataaagg
    10921 atttattcct tgggatgatg atattgatat aatgatgcca cgttcagatt atgagcgatt
    10981 attggagtta gttccttcct tgagacatag ttattataaa atcttaagta atccaaagaa
    11041 tgaggattat tattatactc atgcaaaaat gatagatact cgtactttgt gtgtggaaaa
    11101 tgatttgcaa actattcaaa atatggggat ttgggttgat attttcccct tagacg
//
