LOCUS       c00049_gnlPro..        15820 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGEAFGJL_49.
ACCESSION   c00049_gnlPro..
VERSION     c00049_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 08:41:23
            Original ID  :: gnl|Prokka|CGEAFGJL_49
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15820
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..159)
                     /locus_tag="ctg49_1"
                     /transl_table=11
                     /translation="MTHSQTNTHKHYQQLSFSDRATIQALQAAGDTATVIAQKLHRSKA
                     TISREITR"
     protocluster    1..15820
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2575:5820]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2576..5820
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15820
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15820
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(521..1453)
                     /locus_tag="ctg49_2"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGGPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
     CDS             complement(1483..2451)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg49_3"
                     /sec_met_domain="LysR_substrate (E-value: 1.4e-26,
                     bitscore: 85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.7e-19, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             complement(2576..3427)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_4"
                     /sec_met_domain="Radical_SAM (E-value: 2.4e-25, bitscore:
                     82.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVA
                     SN"
     CDS             complement(3559..5820)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_5"
                     /sec_met_domain="Gly_radical (E-value: 3.6e-41, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.3e-241, bitscore:
                     795.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMNDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDSADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             complement(6072..8516)
                     /locus_tag="ctg49_6"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVINAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGSDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPVQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             complement(8523..10535)
                     /locus_tag="ctg49_7"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKRAFEEHFINGGHPDGTLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLKERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDMQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             11098..11721
                     /locus_tag="ctg49_8"
                     /transl_table=11
                     /translation="LILVLCFILAYFIGAIPFGVVIGKLFYHTDIRKGGSHNIGTTNAY
                     RMLGPVGGSIVLVLDILKGTLAASLPILFGIEHHWLVLIVGLAAVFGHTFSIYIRFRGG
                     KAVATSAGILLAYNPPFFVIAFAIWFSLILLTSMVSVASTLGMVLITAWSLVYHDWLLT
                     TVACGLLVVFLIKHRANFKRIKAGDENMVPFGLGQYLRQHRGRS"
     CDS             complement(11803..12681)
                     /locus_tag="ctg49_9"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHCAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTQFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFEKGYMISIF"
     CDS             complement(12717..14126)
                     /locus_tag="ctg49_10"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEINPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             complement(14170..14694)
                     /locus_tag="ctg49_11"
                     /transl_table=11
                     /translation="MTTIAAVRKDGVTALAGDGQVTLGEKVIMKGNAQKVRRIYHDQVV
                     IGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRKDPTLQKLEAMMIVMDEHD
                     LLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDMTPADIAKEAVNIAGNIDI
                     FTNHNVIVESF"
ORIGIN
        1 acgcgtgatt tctcgtgaga ttgtcgcttt actgcgatga agcttctgtg caatcacggt
       61 cgcggtgtca ccagcagcct gaagggcctg aattgtagca cggtcgctaa aactgagttg
      121 ttggtaatgc ttgtgggtgt tagtctgaga gtgggtcatg aagattcctg ctttcttgtt
      181 tagctagcac taacaagaat aggtcttcat ggcctttatg gtctagtcgt cagggtgttg
      241 cacttgaatt gtaaactggg gagttgaatt cccgaactcg tctcagaatg cgtctctcag
      301 catgcctcaa aaccagccaa aatgacccat gacaacttgc tgttgattcg acccgcgaat
      361 tactacacga atttcaaatt cacgcatcac gagctgctag tcagctttat atttaacaga
      421 tttcgcaaaa agatggctag agactttttg caaacaaaaa agccgcaact ggctagctgc
      481 gactttcctt agaacaattg tgtgcaatta aagatgaaag ttaaccttca aacgtgctct
      541 gcattggcgg aacgacctgt tttttgcggg aaacaacccc aggcaatgcc aaacgcgcgt
      601 ccttgtcgaa ctgttcgttg aaagcactgg cgattttatc gcggtcagca ccgactgcga
      661 aaccagttga attgctgtcc aagatgtcag tggcaatcag caggaaatcg tcgtagcctt
      721 tcgcctgcgc ctctttggtc atggcactga tcaattcgtc ctgacgtgcg taaatgtcgt
      781 tcagatcaac ggtattgacc tgtccgatgc gaatagactt gccgcccatg gtgaaactct
      841 tagcatcgcc ttcgataatg tccatatctg acttggcggc caaattagta cctgccttca
      901 gcatggcaag accatatgac tgcaaatcaa ttccggcaat cttcgccatt tctggcaaaa
      961 tcttcttatc cttatcggtt gcggtcggcg atttcaacaa cagcgtgtct gaaatcaaac
     1021 cagaagccat caaaccagcc aatgttggcg aaatcttgaa gccatattct tggaacatct
     1081 caaaaatgac ggtattggtg ctgccaaccg gttctgctcg gtaaaacagc ggcgctgccg
     1141 tgtggaagtt agcgatgcga tgatggtcga caacagaatc aatcgtcacg tcttcgatat
     1201 cactgacact ttgttgaaat tcgttgtgat caaccaacat gacatgatcc gtctcgttgg
     1261 ctgccgtctt gataacccgc ggtgcctgaa ccttaaagtg atcaaggacg aacttagttt
     1321 catcgttcgg tccgcctaat gctaccgcct caacatccgt gttgcctgcc tgtttctgaa
     1381 attctgccca gctcatggca ctcgtaatcg cgtcggtgtc cgggttctga tgcccaaaaa
     1441 tcaaagtcgt catcttatct gatcgctcct caactgaata gtttacttat caagtttaac
     1501 acggttttca ctgacccgcg acaagtaatc tttttccttc agataatcgt caaaggtctg
     1561 gaagaagttc gagatccgcg gaatgtcagc tttctctttg cgataaacaa aagaaatctc
     1621 aaagcgaatg gccggatcaa acgcaatagc ataggccttg atttgatcag cgcgtgcccg
     1681 aacaaaactg gttggtaagg ccgtgttgac ccctgacaag ttaacgaatt gggttaactg
     1741 atatggcgtg gtgaaatgtg cgaccacgtg cgggaaatca accatttgat tcttgtacgc
     1801 ctcacgcaga agctgtccaa ggaaatagtc gtcaggataa gttgcccaag gttcagctaa
     1861 agtatctttg aaatggattc gcttacggtt agccaaggcg tcatcgtggt gcaagaacag
     1921 caattgttca tcaataattt tcttgctggc gtatggtttc cagttcttaa tggtctcatc
     1981 tggcagattc atgatagcca aatcaatctg gttgttttcc aaggattccc aaatttcgtg
     2041 acgggtcatc atccgtagcg ttacttcaac ttcaggattc agttgatagt aatgagcaat
     2101 gaacgcaata aaggcgctat cctcaattga gcttaataac ccaatattga tttttccgac
     2161 ggttgcactg gttgtttgtt gaatttcgtc ggttgtctgg ttcaagatct cgtagatctc
     2221 atgggttgac tttaacatgg tctgaccagc gtcagataaa tgcagtttct tcccgacaga
     2281 ataaaacagc ggtgccccca ccgtccgttc caatttcttg atctgctgtg ttaaggctgg
     2341 ctgggtaatg ccaagcaatt gggcggcttg ggtgtagttc atggtttctg ccaattgcag
     2401 aaaataagtt agtgtctttg aggaaaaaat gcgctcttgt ttcgttttca tagggcggct
     2461 tccctttcgt ttataattta ataatatcgt tcaaccatca tcataagtgg caatgaaaaa
     2521 aaacgcaacg aatttgccgc gtttttaatc gttacgttaa gttctagcta aagattcagt
     2581 tgctcgcaac tggtttcgga cgccagcttt gccatccggt ataatcctta acgtgcagca
     2641 gattctctgc attcttaacg cgatcggcag acggcggttc gatgccttca agcgggtacg
     2701 taatgccaag ctcgtgatac tttttaacgc ctaacgtgtg atacggaaga atctcaactt
     2761 tttggaccac gtttttgtcc aatgtcgcaa tatagtcccc taaccgtttg agataagggt
     2821 caaagtcagt gcgttccggg accagaacgt ggcgaatcca catgtcatca ccatgcgccg
     2881 acatatactg caccatatcc aaaatattct cattaggaaa accggtgagc tttttatgct
     2941 cggccgaatc aatgtgttta atatcaacta atgagatgtc agtaacagcc atcagctttt
     3001 caaactggcc aaaccacggt tggtcacgcg tgaaggggcc gcctgacgta tcgaggcaag
     3061 tcgaaattcc cagtgcctta gccttggtga agagttcgag aatgaaatcg atttgtacca
     3121 aactctcacc gccactgcag gtaatacccc cttggtcacc ccagaatgct ttatagcgct
     3181 gggcatccgc caaaatttga tcggccgtca tttcttcacc aaccccaatg ttccaggtgt
     3241 cagggttgtg acaatactgg caacgcatgc gacacccttg cataaagaca acgaagcgaa
     3301 taccagggcc atcgaccgaa ccaaaacttt cgaccgagtg aacataccct ttgatcgggc
     3361 catcatgatc ctgaccaact tgttctaaga tatttaatgg gctttgtgac tgatcgatga
     3421 gtttcatctt attgcctcca ctacaacatc atgtgtcgtt ttcaattgat tttcatttca
     3481 ttctgccaaa aaacggcaac agcatcgttg ccgtcttttg gcaaaacagg aatggcttcc
     3541 tgtcttgagt taagctgctt acatttcttc gaagaaggtc cgagcaatga catcgtcttg
     3601 ttgttccttg gtcaaatctg cgaagtagac gcagtagcca gaaacccgaa cggtcaatgt
     3661 tgggtattct tctgggtgct tctgagcatc aatcagggtc tccttgttga agacgttgat
     3721 gttcaaatgc atgccgctgt tttccatata gccgtcaacc atgtgaacca aggtatcctt
     3781 acgagtttca tcatcgtggc ccagtgtgtt cggagtaacc ccaaacgtat tactaatgcc
     3841 gtcagttgcg taatgatacg gaatcttggc ggtggacatc agggatgcca gtgcgccgtt
     3901 cttttctgcg ccatatgccg ggttggcacc tggtgagaat ggttcgcctt tttgacgacc
     3961 gtttggtgtt gtccctgtat tcttaccata aaccacgttg gaagtaatgg tcaggacact
     4021 ggtgctcaac ttcgcgccgc gatacagatg atgcgtgttc atcttgttat agaaggtctt
     4081 aaccaaccac ttagcgatgt catcagcgct atcatcgttg ttaccataac gtggatagtc
     4141 atcattgtca gcaacgaagt caactgcaac accgttttca tcgcgaattg ccttgacatg
     4201 accatacttg attgcactga tggaatcaac cgcgtgtgac aggccggaaa tcccggttgc
     4261 gaaggtccgg ttcagttggg tatccttcaa tgccagctgt gcagcttcat aataatactt
     4321 gtcattcata tagtgaatca cattcaaagc attgacatac gtgtcggcca gccagtccat
     4381 catcttgtcg aacttattca tgaattcttt gtaatcaatg taatcgctgg tgatcggtgc
     4441 atattcaggc cctacttgcg cttcctgaat ttcatctttc ccaccgttga tcgcatacag
     4501 aactgtctta gctaagttag cacgggcacc aaagtattga acgccatcag caattggttg
     4561 tgccgagaca cagcaagcaa taccgtagta atcggtaccc cattcgttgc gcatcaggtc
     4621 atcattttca tattgaatgg ttgaactttg gatggatact tcggttgcat agcgtttgaa
     4681 tccttctggc aagcgttcgc tccaaagcaa ggtgatgttt ggttctggtg ctgcgcccat
     4741 gttgtccaaa gtcttcagga aacggaaagc cgtcttggta acgtggtgac ggccatcatt
     4801 gcccattcct gccaatgaca aggttgccca gattggatcg cctgagaaca gtgagttata
     4861 ttcttcagtc cggatgaaac gaaccatccg caatttcata accaaatgat caatcagttc
     4921 ctgtgcctgt tcttcgttca atttgcctaa gcgcatatcg cgttggatat aagcatcaat
     4981 aaccgtatcg atccggccaa cggacattgc ggcaccgttt tgcgtcttaa cagcagccag
     5041 atagccaaag tagatccact gaacagcttc ttgcgcatta gctgccggac gcgagatgtc
     5101 atagccatat tccttggcca tcttcttcat gtcgtttaag gcacgatatt gttcattgat
     5161 ttcttcacgc agtttgatta catcgtcagt catttcgccg tcgccggtca agttataatc
     5221 cttgaacttc tcagccatta aacgatcgat cccgtaaaca gcgatccgtg ggaaatcaga
     5281 aacaatccgg ccacggccgt atgcgtctgg caagccagtc acgatcttgt aatggcgagc
     5341 ctttcgcata tcaggggtat aagcatcaaa gacaccttgg ttatgggtct tacgatattc
     5401 attgaaaatc ttgtgttctt gaggatctgt cttgaagcca taagattcca atgcatcttc
     5461 agccattcga ataccgccaa atggcatgaa tgctcgtttg aatggcttgt cggtctgaac
     5521 accaacaatc ttttcaagat ctttgttcaa ataaccaggt ccgtgtgagg tgatcgtaga
     5581 aggaatattg ttgtcagcat ccaaaacacc gccatttgca cgttcttgct tctttaaatt
     5641 tagaacctga ttgttcagga ctgttgtcgc ttcagtgggg ccagcaagga aactttcgtc
     5701 cccgtcatat tggttcaggt tatgctcgat aaaatcgcgc acattaattt cttcttgcca
     5761 gtcgccgccg ttaaagcctt cccaataatt aggaactttg gtttcgtcaa gctgtttcat
     5821 agttgtttgc ctcctaaagt ggattacaga tgtgacagtt cttacaaaca cagtataaca
     5881 cgccgccaaa tctatgcaag cgttttattg cccatataat aggcgttata ttgtttttta
     5941 agtgtgcttc gtcgcttctt ttcgcccatg atttcgtcat tttgttaaat tgtgcacaac
     6001 tgatctgtcc tataataatc aaaaatgcca ccatctgtat tagtacagac agtggcgtca
     6061 atgatcacca tttattcgac ttgatctgct ggttcttctt tggtttgaac aaaaactggc
     6121 ttgccaagga catcagtgtc aatgacaaac gaaccattcg aatagcggtc acctgctgga
     6181 tgttgtaccg gattaagggt cgttacctta cccgtatcgg tcaaaacatt caggcgggta
     6241 gcgtcatcga ctgacatcat cgcgacaatc cgatgcggat cacgcttaag ctcacgcaag
     6301 accagtaaac cacgacgggc acgactcatt tccccgacct cgcttaaggc catctttttg
     6361 aaggcgccac gttgggtcaa aataccgacc ttagccgtag ttggatcctt cactagaatg
     6421 aaattgacaa cctcatcgtc tggctttaga tccatacttt taacgccggt tgcccgggca
     6481 ccgacagttg acacatcgct taacgggaat gtcagtccgt aagcgtggcg gctgaccaca
     6541 aagacatcct gttgctgatc agtcgtgaag tatgcattgg tgacaatcgc ggctgggtct
     6601 ttcagcttca tcgccatcat cggcttactc ttgtacgtcc gttgcggctg caaatcactt
     6661 aaggcagttt gtttgatgta cccgtcactt gaccctaaca caaaactgcc agcgccatcg
     6721 agttgatcaa aagcaaacac tgccaagact ttttcgtcag agccaaggcc aactgtttga
     6781 cttaagtgtt cgccggtgtc tttccaacgc gcatcactaa tttcatgcac tggtcgataa
     6841 atgacatttc cggcatttgt cacgatgtaa agatgctgca acgtactcag ttcgccagtg
     6901 aaaatggcaa gatcattggc cttcaaacca ttgtcggccg gatcaaccgc ctgataactg
     6961 cgcagtgaac tgcgtttaac gtacccatca cgagaaacct gcaccataac ggtttcatca
     7021 gccaccgtca ccgttgtcgc cacttcaagc gtttcaattt tggcttgaat gctgctgcga
     7081 cgatcatccc cgtactcctt ggcaatccgc ttcaactcgc cttcaatcac ccgatcgcgg
     7141 gcagcggggc gggccaaaat atcttgatac tcggcgattg ctttcgccaa ttgtgctgct
     7201 tctttctgta aagccgtgat atcggtattg gtcaatcgat acagctgcaa ggaaacaatc
     7261 gcttccgcct gagcttccga aaaatcaaac ttcttgacta agttacgctt agcatctcct
     7321 ttatccttgg aagcacgaat cgcggcgatg acctgatcca aaatcgatag cattttgatc
     7381 aagccttcga caatgtgctg tcgagcagcg gccttgttga ggtcaaaacg cgttcgccga
     7441 gtgaccacat cgcgtcgatg ttcgacgtat gcttccaaca tggccttgag tcctagtaac
     7501 ttcggctgca tgtcggcaat agcgaccatg ttaaagttgt atgcaatttg cagatcggta
     7561 tttttaaata aatagtttaa gatgccatgt gcatcggctt ctttttttaa ttcgatgaca
     7621 acgctaagcc caaaacggtc gctttcgtca cggacttcgg caataccgtc cacttttttg
     7681 ttgatgcgta attcatcgat ttttttaatc atctgcgctt tattgacatc atacggaatc
     7741 tcagtgacca cgatcttctc acgaccgcca cgaatggttt cgatgtgtgt ccgagaacga
     7801 accacgattt taccgcgacc ggtttcgtaa gcttgcttga taccatcaag cccttgaata
     7861 atcccacctg ttggaaaatc gggacccttg acgtattgca ttaaagtatc taaatcagca
     7921 gtgggatgct tcagcaagta taagaccgca ttgatcactt cacgcaagtt atgcggcgga
     7981 atttcggtcg cgtaacctgc agagatgccc gttgcaccat tcaccagcaa attcggaaat
     8041 cctgcgggca acacagttgg ttcctgtgcc gtgtcatcaa agttcaacac catatcgacg
     8101 gtttccttat cgatatcggc cagcatttcc ttgctgattt tgcttaaacg cgcttccgta
     8161 tagcgcattg cagctggcgg atcaccatcc atggaaccgt tattcccgtg catctgaatc
     8221 agtggggccc gtaacttcca atcctggctt agccgaacca tcgcttcata aatggagctg
     8281 tcgccgtggg gatgataatt acccatgaca ttcccgacac ttttagccga cttgcggaag
     8341 cccttatcat acgtattgcc atcttggttc atcgcaaata aaatgcgacg ctgaaccggt
     8401 ttgaggccgt cacgcacatc aggcagcgcc cgttcttgaa taatgtattt cgagtaccgg
     8461 ccaaaccggt cgcccatgac ctcttctaag gtcagttctt gaatctgatt ggccaatggc
     8521 ttttactttc ctttcttgtc cagttgtttg acgatttgct tggcaccaaa ctgtaatttt
     8581 tcgtgattag cagtcggggt ttccaaaata ctgccgtcgt catccatatc aaacttgacg
     8641 ttatgctcaa tccattcccg acgcggctca acgcgatcac ccatcaaagt ggtcacgcgt
     8701 cgttccgcca gctgagcatc gtcaatccga acccggatca aagtccgcgt ctcaggattc
     8761 atagtcgttt cccaaagctg atcggcattc atttccccca gtcctttaaa tcgggtcaat
     8821 gtgtaaccct tgcccatggc tttggtctct ttggccaact cttcatcggt ccaagcataa
     8881 ctgatcttgg ttttagcacc agcgcctttt tgcagccggt acaatggtgg caaagcaatg
     8941 taaattcggc cagcgtcaat cagcggccgc atgtagcgat aaaagaaggt tagtagcaaa
     9001 atctgaatat gcgcgccatc agtatccgca tcagtcataa taatgatttt gtcgtagttg
     9061 gcctgctgca tatcaaaatc cgcaccgaca ccagcgccga tggtgtaaat catcgtattg
     9121 atttcttcgt ttttaacgat gtcctgtaac ttggccttct gagtattcag tactttccct
     9181 cgcaatggca agatcgcctg aaacttccgg tctcggcctt gtttagctga accaccggca
     9241 gaatcccctt cgacgagata caattcgtta cgcttagggt tcttggtttg cgccggggtt
     9301 aatttaccgg aaagcaagcc ttgatccttc ttgcgcttgc gtcccgtccg gctatcatcg
     9361 cgtgcttttc gagccgcttc ccgcgcatca cgggctttga cggctttacg aaccaactct
     9421 tgcgactctt caccgttttc catcaaaaaa gttgacagct tgtcatagac aatcccatcg
     9481 accacagtgc gggcttgcgg cgtaccaagc ttgccctttg tctggccctc aaattgcaaa
     9541 atttcttctg gaatgcggac acttaaaata cctgcaaaac cttcacgcac atcactgcct
     9601 tcaaggttct tgtcgcgttc cttcagcaag ccgacttttc gggcaaattc attgaatgct
     9661 cgcgtcatgc cgctgcgcaa gccaatttca tgcgtcccgc catcaccagt gcgaacgtta
     9721 ttaacaaacg aaatcaggtt ttcagaatag ccatcgttat attggccggc aaaatcaacc
     9781 acgataccgt cctttttgcc ttcaaaattg atcacctgtg acaatgcgtc tttgccttca
     9841 ttaaggtatt taacaaaact gaccaagcca tcagggtagt gataactgtc atgcttgccg
     9901 gtgcgttcat cagtcagatt aatcgtgata tttttcagta gaaaggctga ttcgcgcaag
     9961 cgttcggcca aggtatcata actgaagacg gtggtttgaa aaatagtcgg gtccggcttg
    10021 aacgtgatgg tcgtgccatt cggttcgttg acttttccta acttctgcag cgtgccatca
    10081 ggatgaccgc cattgatgaa atgttcttca aatgcgcgct tatcccgcac aactcgcacg
    10141 gttaatgatt ccgataaggc attgacgacg cttgagccaa ccccatgcaa gccaccagat
    10201 gttttgtaac tattttggtt aaatttcccg ccggcatgta gcacggtcaa aatgacttca
    10261 atcgtcggtt tgccgctcgg atgcatcccc gttggcatcc cgcgaccatg atcctgtacg
    10321 gtcacagagt tatcggcgtg aatcgtcaca ttgatctcat ccccaaaccc cgcgagcgct
    10381 tcatcgacag agttgtccac gatttcatag accaagtgat gcaaaccgcg gccatcggtg
    10441 gaaccaatat acatccccgg acgcttccgc acagcttcca agccatgcag cacctgaatg
    10501 gatgaatcat tatatgcttg cgttgcttta tccatagtaa actccctttt ttgaacaact
    10561 aagttataga atacaccacg cgttgagatt tcagaaataa aaaataagag cgcgagccag
    10621 cccgattaga aaccggagca taagcggcct tgggtgcgat ggttggactt tgaccattgc
    10681 acccaaggtc cttacacgca ggttgctgcg agtgcgttta ggcatcaaca ccatcaacag
    10741 cagacctcac cgtattgctc tcaggactcc tgttttctcc tcaaaatcga cccagctggc
    10801 taataccatc attgttcatt taaattttat tagccgtgtc aatggcccaa agctcagcag
    10861 aaaaccgcac ttccctaagc atggcacata actatgactt cttgacgtga aattcatcgc
    10921 ccgctggcac catatctacg ctgtgccccg ccatgatcct tgcacaagac gccaccaaat
    10981 cgcgccacaa cccgcttcac aggttttatt cgaatgtacg ttcgttttat tctactgacg
    11041 tatcactcaa aagtcaaaaa tgctaaaata gtttctagtt tgagaggagg ggcacatttg
    11101 atacttgtgc tttgttttat actcgcgtat ttcataggcg ccatcccgtt tggtgtggtc
    11161 attggtaaac tcttttatca cacggatatc cgcaaaggcg ggagtcacaa tattggcacc
    11221 acaaatgctt atcgcatgtt agggccagtc ggcggctcaa ttgtcttggt gctggatatc
    11281 ttaaaaggca cgttggctgc cagcttaccc attctctttg gcatcgagca tcattggctg
    11341 gtgctgatcg tgggtttagc ggccgtattc ggtcatacat tttcgatcta cattcgcttt
    11401 agaggcggta aggcggtggc aactagcgct ggcattttac ttgcatataa tccgccattt
    11461 tttgttattg catttgccat ctggtttagt ttgatcttgc taacgtccat ggtcagcgtt
    11521 gccagcacac tgggtatggt gttgatcaca gcttggtcgc ttgtttacca tgattggttg
    11581 ctgacaactg ttgcctgcgg gttgctggtt gtctttttga tcaaacatcg ggcaaacttc
    11641 aaacgcatca aggccggaga tgaaaatatg gtgccctttg gcttaggcca atatcttcgt
    11701 caacaccggg gccgctccta gtcacctttt gatggcaacc aaaaagacat ccgaaactgg
    11761 atgtcttttt ttcatgtacc taatcgacaa actgatgaca ccttagaaaa tgctgatcat
    11821 gtaacccttc tcaaatgccg tgccaggttc aagtcgattg atcccaagtt tgcgcgtcag
    11881 gtcgccagtg ctgccaatcg tgtcggcgat gccccaccaa ggttcgatgc agacaaagtc
    11941 gccagtggtt ggatacggac tccaaacgcc cagatatggg gtatcggtca tggtaacgct
    12001 gacaccatgt ttcgtcttgt cagaaaccaa gttgaaggtt gtcttaccaa gcaacgcgaa
    12061 aattaaagca tcatgatcaa atgtttcgtg cgttaaggcc aaattggcat cagttgcagc
    12121 caaggtccgg tgcgtgtaat caatgccttc accagcaacc aatggaatct gaacaagcga
    12181 cttacgcggt ttgaagttca aataataatc ggagaattga gtatccggcg tcattgggac
    12241 cttgaagccc ggatggccgc cgatgctaaa gaacagtggc tcacttttgt ccggattgtc
    12301 aacgtgatac gtgacatgta gattgttatt ttctagtgca aacgtgatga ttaaacgaaa
    12361 agcgaacggg tacatcgccc gcgttttgtc atcatccttc agaacgaagc tcgctttaaa
    12421 cggtgtcgca gagagcaccg tgaaatcacg atcacgggca aaaccgtgct ggcccatgtg
    12481 gtaagtcttg cctgcgtaat gatattgatt gtcagccagc gccccaacaa tcgggaacaa
    12541 gaccggggcg tggcgacccc acaccgcagg atctgcttgc cacagacgct ccctgcctgt
    12601 caggttatct ttgatactgg tcagttcagc acaatgccga ctgattttaa ctgtcaaaaa
    12661 gtcatttgca atcgttacca tacatcctca tcctttacct acaacattat tgttaactac
    12721 aaaatatacc gcgtcatgtt tgaatcagcc gcaatatggc caatcttgtc atccacatat
    12781 tgctgggtga cggtcacact gcccatcgcc atatctggac cttcataaag tacgtcttca
    12841 agcagttttt caagaatggt cgccagtcgc cgcgctccaa tattatcagt gtcgtggttg
    12901 acctgagtcg caatctctgc aattcgatca accgcttcct tcgtgaaggt aatcttcacg
    12961 ccatctgcac caatcaaggc gatatactgc ttgatcaaag cattgtctgg ctcggtcaag
    13021 atccgcacaa agtctttttc ggttaagtcc ttcaattcaa cccgaattgg aaaacgccct
    13081 tgaagttcag caatcaaatc actaggctta gcctcggcaa acgcacctga tccaatgaac
    13141 aagatgtgat ccgtattgat aggaccatac ttagtgttaa tctgcgatcc ttctacaatc
    13201 ggtaaaatat ctcgctgcac accttcacgc gaaacttcgc cgctattatg cttgtttcct
    13261 gcagcaattt tatcgatttc gtcgatgaaa atgatcccgt tattctcggc actttgaatg
    13321 gcgtcgtgat agatgtcggc atgattgacc agtttgtcag attcctcttt gatgaagatt
    13381 tcgcgagctt ctttgacggt catggtccgc tcaacctttt tcttaggcat taaagcgcca
    13441 atggtgtcgc ttagatcaat gcccatctga ccgtacatgt cacccatgcc accgcctttt
    13501 ttctcatcat tgacagcaac ggtgatttca tgatcttcaa gtaatccttt ttccagttgc
    13561 tctgccacgc tcaaacgctt attgcgaata tcatcggtca cttcgccgcc tgcgtctgca
    13621 tcatcgccag ctggcatttt gccattttgc atcccttgca acatgctcat catctcggcc
    13681 atcggattgg tattcttttc cttacgaatg gccggcacta aaattttaac caaacgctta
    13741 ttggcttctt tttcggcacg tatgcgaacc tttgaaaatt gcttctcttc ttccatggca
    13801 acggcagttt cggcaagatc tcggaccatg gattcgacgt cacggccaac gtagccaact
    13861 tccgtaaact tagtcgcttc caccttcaca aatggcgcct caactatttt cgccagtcgt
    13921 cgtgcaattt cggttttccc gacaccggtt ggtccgatca tcagtaagtt tttcgggtta
    13981 atctcttctt gcatttttgg cgataattgc attcgccgat aacggttata caaggcaacc
    14041 gcgacggccc gttttgcatc atcttgtcca atgacatatt gatcgagttt ttcaacgatc
    14101 tgttttgggg tttgtacttc tgccatcata agcctcctgt agatcaatgt aattgccgac
    14161 ggttacaaac taaaagcttt cgacaataac attgtggttt gtgaaaatat cgatatttcc
    14221 tgcgatattc accgcttctt tggcaatgtc agctggtgtc atatccgggg catgccgcag
    14281 catcgcgatt gccgcggctt gcgcaaagtt gccgccagag ccgatcgcta ccacgtcttc
    14341 atctggatct atcacttcgc cagacccgga tacaagtaac aggtcatgct catccatcac
    14401 gatcatcatg gcctcaagtt tctgcaaggt cggatccttg cgccaatctt gagccagcgc
    14461 aactgcggaa cgtcgcaagt tgcccgcata atgctccagc ttcttttcaa accagtcttg
    14521 cagggtgaaa gcatctgcta ccccgccggc aaatccgatg acgacttgat catgatagat
    14581 ccggcgaact ttctgcgcgt tgcctttcat gatgaccttt tcgccaaggg ttacctgacc
    14641 gtcaccggcc aaagcggtca caccatcttt tcttactgct gcaattgttg tcatagtcat
    14701 gctccttttt aagtgagcgc aagcagaagc gcttagaaac cggagcataa gtgggctgca
    14761 agcctaaatg gctgaatttt ggctatttag gcttccaggt cattatgtgc aggtttctgc
    14821 gactgcgagc gcgttatctg cgtatctcgt cggataaaaa cagctaaagt agcgattaat
    14881 ctgttatcgc caatgttctt agcttaaaaa actcagactg cttttgcatc atgctttagt
    14941 cttaattatg cttcggataa tatttcatat actcattttt taaatgtgcc atggtgacat
    15001 gcgtgtagat ttgtgtggtt gataaacttg catgacccag tagctcttga acagttcgca
    15061 ggtcagcacc atgatccagc atatgggttg caaaactatg ccgcagcatg tggggatgaa
    15121 tgttagctgt cagcgtcgtc tgcttgatga gctgatccaa aatatattca atgccacgcg
    15181 aggtaatcgg acgcccatac tggttcacaa atacatatcg atgctgtgcc tgacttttag
    15241 ccatcaagac ttgtcggcca tcttttaaat aagttcgtag tgcttgctga gcgtactgtc
    15301 caaagggcac atacctatct ttgttgcctt taccatgaat caacagtaat gccgtattga
    15361 aatcgacctg attcaatgtc agtttggcac actcggaaac tcgaataccg gtgccataca
    15421 aaacttccaa caaagcgcga ttacgttgat ccagcggggt tttgccagca actgtcttga
    15481 acagttcctg aatctcggct tcatagaaaa attgtggtaa atgatgatgc tgctttttta
    15541 attcaaccag ctcaaatggg ttgcgtttga cgacatcaat tcgtgtcaaa taacggtaaa
    15601 agcttctcaa actactgatt tttcgggcaa tcgatgtccg tgccaaatcc tgtttgttaa
    15661 gatcagtcaa ataagtttga acgtctaaat catccacatg ccgaaagtca gtaaacccgc
    15721 cgttggcctt gagaaacgcc tgaaattctc gaagatcact caaataagcc gtcactgttt
    15781 ccggtgaata ctgccgttca acttcaagat actcctgaaa
//
