LOCUS       c00162_gnlPro..        14522 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILOCADDH_162.
ACCESSION   c00162_gnlPro..
VERSION     c00162_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 20:48:21
            Original ID  :: gnl|Prokka|ILOCADDH_162
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14522
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14522
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[556:4522]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      557..4522
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14522
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14522
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(2..277)
                     /locus_tag="ctg162_1"
                     /transl_table=11
                     /translation="MLITIIILVLSAVFFVNGKIRSDLVALCALVALLIFQILTPDEAL
                     SGFSNSVVIMMVGLFVVGGAIFQTGLAKMISSHILKLAGKSELKLFL"
     CDS             557..862
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_2"
                     /sec_met_domain="HBT (E-value: 1.5e-14, bitscore: 44.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVDHRTSQPFGMLNGGASLALAEIVAGHGSTSLCREGEYACGVQ
                     VSGNHLSAVPVGGKVFATGKLIHRGRSSHIWNIDITTPQGQLVSTVRVVNFILKKK"
     CDS             859..2001
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg162_3"
                     /sec_met_domain="Chorismate_bind (E-value: 1e-57, bitscore:
                     186.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQKLLDCLTHSRLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNGKKGFVMAPFRISEEHPLVLIRPDVTAYDWSEISEALSSLECADALLTCKS
                     RQSELSPFVSEETDKEQYTRAFGRFITPLQEKRFQKLVLSRSSARHIGDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGHGKEWHTVALAGTMPMQNEVMPTDWDK
                     KNREEQGYVADYIRRIAKRFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFIPDNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWMETGDKMNTMRSILHPDFINK"
     CDS             2028..3701
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-07, bitscore:
                     21.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLKAHGVRKIVLCPGSRNAAIVHTLANIEDFT
                     CYSVTDERSAGFFAIGLSLQGGGPAAVCCTSGSALLNLHPAVAEAFYQQVPLIVISADR
                     PAAWIGQMDGQTLPQPHVFGTLVKMSVNLPEVHTEEDEWFCNRLINEAILETTHHGKGP
                     VHINVPISEPIYRFTAKTLPEVRVITRYQGLSVYDRDYKELIERLNKYNKRMVVVGQMN
                     LIYLFEKKYVKPLYKHFAWLTEHLGNQTIPGIPIKNFDAAVYSMTPERQEDMAPEILIT
                     YGGHIVSKQLKKYLRNHPPREHWHVAADGKIADLYGCLTTVIEMDPFEFLEKIAFLLDN
                     KPTHYPLMWENYCKTIPMPDLAYSEISVIGKLIRALPEPCALHLANSSTVRYAQLFTVP
                     PQVEICCNRGVNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGANIRI
                     LLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEELEEAM
                     QPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             3701..4522
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_5"
                     /sec_met_domain="ECH_1 (E-value: 9.2e-85, bitscore: 274.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEI
                     SDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIR
                     SLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIV
                     GQKKAREIWFLCRQYSAQEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKA
                     GLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             4600..5655
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg162_6"
                     /sec_met_domain="MR_MLE_C (E-value: 1.3e-29, bitscore:
                     93.6, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQTRIIKKQLHFKQPAGTSRGVYTTRNVWYILLTDTGSRHYGVG
                     ECAPLPALSCDDIPSYDEVLATACKNLEKNGEIDREALLPYPSILFGMETALLHFRARS
                     LQFWHTPFSKGKEGIPINGLIWMGNFDEMYRRIGEKMQQGFRCIKLKIGAIDFEKELEL
                     LAHIRRHFTPAQIELRVDANGAFSPADALEKLHRLSEFQLHSIEQPIRAGQWNEMARLC
                     AATPFPIALDEELIGINRRDRKIELLETIRPQYIILKPSLHGGISGSEEWMELAAERGI
                     GSWVTSALESNIGLNAIAQWCATLQPALPQGLGTGLLFTDNIDYPLHIEGDCLWFHPEE
                     QEPDLLNWLKQ"
     CDS             5652..6737
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 56; E-value: 8.9e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg162_7"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-18, bitscore:
                     56.0, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 2.2e-08, bitscore:
                     25.5, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFCTNRNKQTILIESIPYSNWEIEMVRMNIPADNRSFRQELLS
                     FLSEWFDPADTLPVHTSGSTGKPKELYVEKERMMESACLTCSFLGLQKEDSALLCMPLQ
                     YIAGKMVVIRALVAGLDLLPVTPSGHPLKDLTKAPVFAAMIPMQVYNSLQVPEEKAILQ
                     QIRHLIIGGGPIDSQLNAALKDFPHAVWSTYGMTETLSHIALRRLNGPEASDWYTPFES
                     IQIRLSKENTLVIYAPEICEKELVTNDIAEINGQNQFRILGRKDNTINTGGVKVQIEQV
                     EAALKEHLSVPFLITSAPDEKFGEIIVLLAEEQLPDDIEQTCTHQLPPYWRPKRFVPVF
                     KLPLTETGKPDRAIAKLLAQK"
     CDS             6993..7877
                     /locus_tag="ctg162_8"
                     /transl_table=11
                     /translation="MLYNNPKPQDTKEGLSDQDFSIYMDAHTVPFSKYPSYMPAGVLGI
                     CTEGNAEIQVGLRKYVICANDILIFMPGFLVSFIKSSPTFTIDYCTFSNVLFYDVINGS
                     IKRFPTGFHTYTQTHCVYSLSQEKAEQFSIYFRLLYNRATSPTYLFTKESITNLLKLPF
                     LELYADYYSTVKEHKVTTLHKEEIGYFFLDLLLKHYKENKEVAFYAEKLHVSSKYLTEA
                     LTLVSGKSPKEWIIHYTLQEIYALLENPSISIQEIVQRTRFANLATLRRFFKRHTGTSL
                     LQYRKQDLYKNNQ"
     CDS             complement(7940..8116)
                     /locus_tag="ctg162_9"
                     /transl_table=11
                     /translation="MELPDDPMMLFSMVNMKLRDCYHSLDELCDDMNVHKELLVKKLKA
                     AGFEYSKENNKFW"
     CDS             complement(8231..10510)
                     /locus_tag="ctg162_10"
                     /transl_table=11
                     /translation="MLRDYQIEMKTRLMEAWKAHRSVMVQMPTGTGKTHLLASVVSEFV
                     SSAGSGVWLIAHRRELVAQMEETLAKYGIRREDTPVRVMSVQWLSRHWNEAGDAPGLIV
                     IDEAHHALAASYTEMWKRYPAAKKLGVTATPCRLNRRGFTELFEVLVTSWSIAEFIEKG
                     VLSVFDYVSIRPGSEEQRLIDGLEKRGADGDYQVKEMDAVLNRRPGIERLYRSVRQFAS
                     GKKGMVYAISIEHARRIAEYYSRRGVNAVAVDSKTPAMERKRMVEEFRHGKIEVLVNVD
                     VFSEGFDCPDVEFVQLARPTLSLAKYLQQVGRGLRRSEGKEACMLIDNVGLYRIFGLPT
                     QRWNWDAMFRGRMAGKGSLPGRMNCDASVTAFPVVERPAEAGGDLVVVMEHGRLLSSIR
                     EQVLPDEKEQSLSCRLRAFVDKETGLWGLEKGDEMLPDASFKEILSIKGRFAVGRLRNG
                     CVRVLDDTGALVVEPGHCREVRFLKDDLLQVRHAGNSVSYVDLRNGRCYSVRPRVLRYG
                     SIELLQANRTYYSRTRQVYANTCGLPSSSIVWMGFYVKMYDGRVPSRCRRMEDGGFCCE
                     PQVCLLEGDEERAYYLSGRLPDQSIVVMDEEGRYYHVEKGHGKRYVACNRPSDRSEDFD
                     EAVALLRRQADERVEKRLREEKCEYERKRQRIISRSVEAVPFQIGVKWGLRTAERILIP
                     PVYRRILHPVGGYCAYQDSSCQWGVLAVDGRIIIRARYMEVEIDRDGTARLTLVPGKME
                     TVKLTD"
     CDS             complement(10566..11015)
                     /locus_tag="ctg162_11"
                     /transl_table=11
                     /translation="MMINIYGGNNLIAPVASSAIQNFYGDRGDEAADQPEGSEKTESTE
                     SVTDEKPAQEPAELSDDEFYVSVYIPDIKVMRAYKILWGECTTARELAVVVGKMLADEN
                     CRNVDKHTVVKAAFIKSLLPFAKRLVSGGTIANIRAQINNMLASK"
     CDS             11219..11788
                     /locus_tag="ctg162_12"
                     /transl_table=11
                     /translation="MKEYIMSFFNAPVTNKIPTCICSVAGLHTYISTNPQLEELTRKVR
                     AGLGNKQVFRKNKQTLLPYVTPAGIFSYCKEQCMQVPSGLFVIDIDELASTEEAAMWRD
                     RLFADEVLHPVLSFVSPGNQGVKLFIPYRINPFLSVEESFDNALHTAWEYLEWKYELKV
                     DRANADLSRACFLSHDGEAKINNHKY"
     CDS             11792..13735
                     /locus_tag="ctg162_13"
                     /transl_table=11
                     /translation="MNDSISILEQLVTAIEQAGVNVAPTYQEYMPLAFAIANSCGEEGR
                     TRFHRICRISEKYHHDEADKLYGHALTKGTGRNSLGTVFHLAEVAGVKMDPKLANLQNL
                     QSLHTHTRARVSYNAHLDASDGTPPDAVFTDPASPLSDGVSKTILPARLPYFPDYRWPA
                     FLQGIIDCGNSPAQRDILLLGAATVLGSTLNKLVSFVYGRKHKYPCLQVFVTAPPASGK
                     GALTWVRRLAEPIHNALLDTYREKIKTYRMEKTKWDTLGKEKANTPEPEQPQLKMLLIA
                     GDNTGTGIQENLMDSGGVGLICETEADTVSTAIGGDHGHWSDLLRKCFDHDRLAYNRRT
                     NHEYRECNVTFLCVLLSGTPAQIKPLIPSAENGLFSRQLFYYMPAIEEWEDQFNEADTD
                     YDSRFLEWGAQWKEVLDAITASVSNINMKLTHEQKEIFNFHFARVFGRASAIHGNQMKS
                     AVTRIAINIFRIISIIALLRSLESLLPGGERSGEPQENIVRTLLNCPGLTPSAHIPQEN
                     IADGIVPQFNLSIRTDDFYAVLALVEPLYRHACHILSLLPAGTPTAPSANMTPETLFDC
                     LPLRFTRNEAIDKGEQVGVPAGSVDSLLKRMTERGQLVKVGRGEYEFNARMHTRTCVGV
                     RESASSASLQDS"
     CDS             13753..13977
                     /locus_tag="ctg162_14"
                     /transl_table=11
                     /translation="MKDFLYFPSMTKGSLALLYFPGSNPRIATRHLMRWINGCPPLMEE
                     LSATGYHTSQKVFTSRQVTLINRHLGSPG"
ORIGIN
        1 gcaagaataa tttcaattca ctcttacccg ctaatttcag aatgtgtgaa ctgatcattt
       61 tggcaagtcc tgtctggaaa atcgctccgc caaccacaaa cagccccacc atcataatga
      121 cgaccgaatt ggagaatccg gacaaagcct cgtcaggagt caatatctga aaaatcaaca
      181 aagccactaa agcacaaaga gccacaagat ccgaccgtat cttgccattt acaaaaaata
      241 ctgcggacag tacaaggata ataatcgtaa tgagcataag tattaaatta ttgttttatt
      301 cattcgttgt tgcatttgta caagttcttt ttgcaaaata aaaaatatat tccgataata
      361 gaaacaaacc ccgaatgttt ttgttcttaa aagaacaaca tgaacgacat tttcatctaa
      421 aatttatgta tttttgtagc cctatagaaa agaacagaca tacaaatgat ggaagaaaca
      481 acctgcaaac ctgattattc gaattcgact gggtatccgg tttctaccct ccaccgagga
      541 tgcggtacat gccgaaatgc ctgtagacca tcgtacttca caaccctttg gtatgttgaa
      601 cggcggcgcg tcactggctc tggccgagat tgtggcaggg catggctcta cgtcgctatg
      661 ccgggaaggc gaatatgcct gcggagtaca agtaagtgga aatcatctgt cggccgtgcc
      721 cgtcggaggc aaagtattcg ccaccggcaa actgattcac cgcggcagat cctcgcatat
      781 atggaatata gatatcacca ctccacaagg acaactggtt tctactgttc gtgtcgttaa
      841 tttcatactg aaaaagaaat gaatctacca gatatacata cgcaaaaatt attggattgc
      901 ctgacacaca gccgcctcgg tttcgccctc taccggttac cttggacaga cgaatgctac
      961 ctggtattgc aaacctcagg cgatgtggaa caattagcgg acattcagga actgaatgga
     1021 aagaaaggat ttgtcatggc tcctttccgg atatcggagg aacatccctt ggtacttatc
     1081 cgtccggatg tcaccgcata cgactggagc gaaatcagcg aagcactgtc ttcactggaa
     1141 tgtgcggatg ccctgctcac ctgcaaaagc cggcagagtg aactctcccc ttttgtttcc
     1201 gaagaaacgg ataaagaaca atatacccgc gcattcgggc gtttcatcac tcccttacaa
     1261 gagaagcggt tccagaaact ggttctgtca cgttcttccg ccagacatat cggagatgat
     1321 ttttcaccac tcggcgcttt tgtccgggcc tgcaacaact atccgcgcat gatgatttac
     1381 ctatgccaca cccctgcttc cggaacctgg ctgggcagca caccggaaat cttattaagc
     1441 ggacacggca aagaatggca caccgtggcc ctggccggta ccatgccgat gcagaacgaa
     1501 gtgatgccga cagactggga caagaagaac cgggaagagc agggctatgt ggctgattac
     1561 atccgccgga tcgccaaaag attcggcaac aagatgacgg aaaaaggtcc ttataccgcc
     1621 cgtgccggac aattggtaca cctcaagacc gatttttatt tcttgttgaa aaatacagac
     1681 catataggcg atttattgca agaactccat cccactcccg ccgtctgcgg cctgcccaaa
     1741 gaggaggctt tccggtttat tccggacaat gaagggtacg accgcagtta ttattccgga
     1801 ttcaccggct ggctggacac agaggggcat accgatatct acgtcaatct gcgctgcatg
     1861 gaaataaagc cgggtgaagc catcctgtat gcaggaggag gaatactggc ttcctcggaa
     1921 gtagaatcgg aatggatgga aacgggagac aagatgaata cgatgcggag catccttcat
     1981 cctgacttta taaataaata aatggaaaca attaaagtag aagaataatg tattcagaca
     2041 aaaagaacat acttcagttg gtggcacttc tcaaagcgca cggtgtgcgg aaaatagtgc
     2101 tttgtcccgg cagccgtaat gctgccatcg tacatactct ggccaatata gaggacttca
     2161 cttgttattc tgtaaccgat gaacgcagtg ccggtttttt tgccatcggc ctatctttac
     2221 aagggggagg ccctgccgca gtatgctgca cttccggttc ggccctgctg aacctgcacc
     2281 ctgccgtagc cgaagccttt taccaacaag tacctctgat tgtcatttcc gccgaccgcc
     2341 ccgctgcctg gataggacaa atggacggac aaaccctgcc ccagccccat gtgttcggaa
     2401 cgttagtcaa gatgtctgtc aacctgcccg aagtacatac tgaggaagac gaatggtttt
     2461 gcaaccgcct tatcaacgaa gccatactgg aaaccaccca ccacggcaaa gggcctgtac
     2521 atatcaatgt acccatttcc gaacccattt accgcttcac cgccaaaaca cttcccgaag
     2581 tacgtgtcat cacccgttat cagggactga gcgtgtacga ccgtgactat aaggaactga
     2641 tcgaacggct gaacaagtac aacaagcgca tggttgtggt aggccagatg aatctgattt
     2701 acctgttcga gaaaaaatat gtgaaaccgc tttataaaca tttcgcctgg ctgacggaac
     2761 atctaggcaa ccagaccatc cccggcattc ctatcaagaa tttcgacgcc gccgtttatt
     2821 ccatgacacc ggaacgccag gaagacatgg cccccgaaat actgattacc tacggcggac
     2881 acatcgtatc caaacaattg aagaaatacc tgcgcaatca tcccccgcgc gaacactggc
     2941 atgttgccgc cgacgggaag atagccgatt tatacggttg cctgaccacc gtcatcgaga
     3001 tggatccgtt tgagttcttg gaaaaaatag ctttcctgct ggacaacaaa cctacccatt
     3061 atccgctgat gtgggaaaac tattgcaaaa ccattccgat gccggacctt gcttattccg
     3121 aaatctccgt tatcggaaaa ctcatccggg cattgcccga accctgtgcc ctgcatctgg
     3181 caaacagctc caccgtgcgc tatgcacagt tatttacagt tcctccccag gtggaaatct
     3241 gttgcaaccg gggagtgaac ggcatagaag gctccctgtc caccgccatc ggttatgccg
     3301 ccgcttccag caagctgaat ttcatcatca taggcgactt gagcttcttc tatgacatga
     3361 acgcactgtg gaatcaaaat tacggtgcca acatccgcat cctgttactg aataacgaag
     3421 gaggagaaat attccacacc ctgcctggaa tggacaaatc aagccgttcc agggagttta
     3481 tcacagccga gcattacacc accgccaaag gctgggcgga agaacgcggc tttatttaca
     3541 tgaaagtgac cggagaagaa gagctggaag aagcgatgca gccattcacc tcacccgaga
     3601 cacggatgca acccatgctg ctggaggtgt ttaccgacaa ggaaaaagac accaccctgt
     3661 taagagaata ttatcacgga cttaaaaata aaaatgaata atggaaacaa gagaatggaa
     3721 aaccatcaaa gaatatcagg atattctgtt tgacttttac aacggaatag cgaaaatcac
     3781 catcaaccgt ccgcgttacc gcaacgcgtt cacccccacc accacttcgg aaatcagcga
     3841 cgccctgtat tactgccgcg agtgccagga tatcaatgta gtggttctga ccggagcagg
     3901 cgacaaagcc ttctgcagcg ggggagatat gcacgtaaag gggcatggcg gctatatcgg
     3961 cacagatgga gttccccgtc tgaatgtgct ggacgtacaa aagcaaatcc ggtcactgcc
     4021 taaaccggtc atcgccatgg taaacggtta cgccatcggc ggcggtcatg tgctgcatgt
     4081 ggtatgcgat ctgaccattg cctcagagaa tgccattttc ggacagacag gtcccaaggt
     4141 aggcagcttc gacgccggat tcggctcttc ctatctggca cgcatcgtag ggcagaagaa
     4201 agcccgtgaa atatggttcc tttgccgtca atactccgca caggaagcac tggaaatggg
     4261 attggtcaat acagtcgttc ctttctaccg cctggaagac gaaaccgtgg catgggcaga
     4321 aaagatgatg gagcacagcc cgctcgctct tcgtatgatc aaagccggac tgaatgccga
     4381 actggacgga caagccggca tacaagaact tgccggagat gccaccatgc tgtattacat
     4441 gacagaggaa gcacaggaag gaggaaaggc atttttggaa aaacgcaagc cacggttcca
     4501 ggattatccg aagttcccat aatcagtggt tcatttttcc ggtggaggac aacccaatag
     4561 tcctccttgc ttcccattaa ccactaatca ctaataagaa tgttccaaac ccgaattata
     4621 aaaaaacaat tacacttcaa gcaaccggca ggtacttcca gaggagtata taccacccgg
     4681 aatgtatggt acatcctcct caccgacacc ggcagccgcc actatggcgt gggtgaatgt
     4741 gcccctctcc ctgccctgag ttgtgacgat atcccctcat acgacgaggt gttggccact
     4801 gcctgcaaga acctggaaaa gaacggggaa atagaccggg aagccttgct tccctatccg
     4861 tccatcctgt tcggtatgga aaccgccctg ctgcatttcc gggcacgcag cctgcaattc
     4921 tggcacaccc cgttcagcaa aggcaaagag ggcatcccca tcaacggact catctggatg
     4981 ggaaactttg acgagatgta ccggcgcatc ggggaaaaga tgcagcaagg cttccgctgc
     5041 atcaaactca aaataggcgc catcgacttt gaaaaggaac tggagctgct ggcgcacatc
     5101 cgccggcatt tcaccccagc ccaaatcgaa ctgcgtgtag atgccaacgg tgctttctct
     5161 cctgccgatg ccctcgaaaa gttacatcgt ctttccgaat tccagctcca ttccatcgaa
     5221 cagcccatcc gtgcggggca atggaatgaa atggcccggc tctgtgccgc cacccccttt
     5281 cccattgcac tggatgaaga gctgataggc atcaaccggc gcgaccggaa aatagaattg
     5341 ctggaaacca tccgtcctca gtacattatc ctgaaacctt ctctgcacgg aggaatcagc
     5401 ggctccgaag aatggatgga actggcggct gaaagaggca tcggctcatg ggtcacttcc
     5461 gctctggagt ccaatatcgg actgaatgcc atcgcacaat ggtgtgccac cttgcagccc
     5521 gccctccccc aaggactagg taccggcttg ctgtttaccg acaatataga ctatccgctt
     5581 cacatcgaag gggactgcct ttggttccac cccgaagaac aagaacccga cttactaaac
     5641 tggctgaaac aatgacaaaa ttctgcacca atagaaacaa acagaccatt ctgatagaaa
     5701 gcatccccta ctccaactgg gaaattgaaa tggtaagaat gaatatccct gccgacaacc
     5761 gaagcttccg gcaggaactt ctctcctttc tttccgaatg gtttgacccg gcagacaccc
     5821 tgccggtaca tacttcaggc tccaccggca aacccaagga actgtatgta gaaaaagaac
     5881 gcatgatgga aagcgcctgc ctcacctgtt ccttcctcgg actgcaaaaa gaagattccg
     5941 ccctgctttg tatgcccttg caatacattg ccggaaaaat ggtggtaata cgtgccttgg
     6001 tagcgggact ggacttgctg cctgtcactc catccgggca tcctttaaaa gacctgacaa
     6061 aagcccccgt ctttgccgcc atgatcccca tgcaagtcta taactcactg caagttcccg
     6121 aagagaaagc gatattgcaa caaatcagac acctcattat cggaggcggt cctatcgact
     6181 cccaactgaa cgctgcgtta aaagatttcc cccatgccgt atggtctacc tacggcatga
     6241 ccgaaacctt gtcacacatt gccctacgca gactgaacgg tcctgaagct tcagactggt
     6301 acaccccttt cgagagcata cagatccgtc tgagtaaaga aaacaccttg gtgatatacg
     6361 ctcccgaaat ttgcgaaaaa gaactggtga ccaatgacat agccgagata aacggacaga
     6421 accaattccg cattctaggc agaaaagaca acacgatcaa tacaggagga gtaaaagtgc
     6481 agatagaaca agtagaggcc gcattgaaag aacacctgtc cgttcctttc ctgatcacct
     6541 ccgcccccga cgaaaaattc ggagaaatca ttgtactgct tgccgaagaa caactgcccg
     6601 acgacataga acagacctgc acacatcaat tacctcccta ctggcgtccc aaacgttttg
     6661 ttccggtatt caaacttccc ctgacagaaa ccgggaaacc cgaccgtgcc atagccaaat
     6721 tactggcgca aaaataactc cgatccattc ataaagggtg aattcaaaaa ccaatcaaac
     6781 ggtctttttg aattcaccct tctttctgta aaaaagaata attttccgtg ttctcctaca
     6841 acttacggaa agctcaaatt gttttcctat cagtatatta aaaaaatcaa atacacgtag
     6901 tttttttccg ttttattttc ccttatgtcc actactcccg gtggaatgta tcattaaatt
     6961 ctaattttgt gaagctagat ttgatacaaa gtatgttata taataaccca aaaccacagg
     7021 ataccaaaga aggactgtcc gaccaagatt tcagtattta tatggatgcg cacacagtgc
     7081 ctttcagcaa atacccctct tatatgccgg caggagtttt gggtatatgt accgaaggaa
     7141 atgccgagat ccaggttggc ctccggaaat atgttatttg cgcaaacgac attcttattt
     7201 tcatgccggg attcctggtt tcatttataa aatccagccc gactttcacc atcgactatt
     7261 gtactttttc aaatgtcctt ttttatgacg tgatcaatgg aagtatcaaa cgttttccga
     7321 ccggttttca tacctacacc cagacccact gcgtctattc gctatcccaa gagaaagcgg
     7381 aacagttctc catctatttc cggttattat acaacagagc cacttcgcca acttatttat
     7441 ttacaaaaga atctattacc aatctgctga aattaccttt tctggaactt tatgcagact
     7501 attacagcac ggtaaaagaa cataaagtca ccaccttgca taaagaagaa atcggatact
     7561 tttttctgga tttgctgtta aagcattaca aagaaaacaa agaagtggcg ttctatgccg
     7621 aaaagttgca tgtttcctcc aaatacctga ctgaagcctt gaccctggta agcggaaaat
     7681 cccccaaaga atggattata cattataccc tgcaagagat ttacgcacta ttggagaatc
     7741 catccatcag catacaggaa atcgttcaaa gaacccggtt tgccaatctt gccaccttaa
     7801 gacgtttctt caagcgacat accggaacat ccctgttgca ataccggaaa caggacttat
     7861 acaaaaataa tcaataggta cctcaataaa aaaatcagcc cgttccacac attcttccgg
     7921 aacgggctga tccctctatc taccaaaact tgttgttttc cttactatac tcaaatccgg
     7981 ccgccttcag ttttttcacc aacagctcct tgtgtacatt catatcatca caaagctcgt
     8041 ccagcgaatg atagcagtca cgaagtttca tattcaccat gctgaaaagc atcatcgggt
     8101 catcaggtaa ttccatatca atatctcctt tttaaaaatc ggatgcaaag ttacaaaact
     8161 tttcataatg atatgtattc catcgccaaa tatcggtttg acaaaaagtt atcccctgct
     8221 ttttattcta tcagtccgtc agcttcaccg tttccatctt ccccggaacc aaagtaagac
     8281 gcgccgttcc atccctgtct atctccactt ccatataccg ggcccggata atgatccttc
     8341 catctacagc cagtaccccc cactggcagg aactgtcctg ataggcgcaa taaccaccca
     8401 ccggatgcaa tatcctccga tagacaggtg gaatcaaaat ccgctccgct gtcctcagcc
     8461 cccatttcac tcctatttga aaaggtacgg cctccacact cctgctgatt atacgctgcc
     8521 gtttccgttc atactcgcac ttctcctcac gcaagcgttt ctccacacgc tcgtccgcct
     8581 gtcttcggag caatgccacc gcctcatcaa aatcctcact ccggtccgac ggacggttac
     8641 aggccacata acgctttcca tgccctttct ccacatggta ataccgtccc tcctcatcca
     8701 tcaccacaat actttgatcc ggcaaccgtc cgctcaggta ataagcacgc tcctcatccc
     8761 cctccaacag acaaacctgc ggttcacaac aaaagcctcc atcttccatg cggcggcatc
     8821 gggaaggcac tctgccatcg tacatcttca cataaaaccc catccacacg atggacgaag
     8881 aaggcaaccc gcatgtattg gcatacacct gccttgtcct gctgtaataa gtacggttcg
     8941 cctgtaacaa ttctatgctc ccgtatctga ggacacgcgg gcggacagaa taacaccggc
     9001 cgttccgtaa atccacataa gacaccgaat tcccggcatg acggacttgc aacaaatcat
     9061 ctttcagaaa cctcacctca cggcaatgcc ccggttcgac caccaaagcc cccgtatcat
     9121 ccagtacccg gacacacccg ttccgaagcc tccccacggc aaaacgtcct ttgatactca
     9181 aaatctcttt aaacgaagcg tccggcagca tctcatctcc cttttccaat ccccaaagac
     9241 ctgtttcctt atctacaaat gccctcagcc tgcatgacag tgactgctcc ttctcatccg
     9301 gcaaaacctg ctctctgatg gaagaaagca aacgcccgtg ctccataacc accaccaagt
     9361 ccccaccggc ttcagccggc ctttccacca ccggaaaagc ggtaacggaa gcatcacagt
     9421 tcatccgtcc gggcaaactc ccctttcccg ccatccgtcc ccggaacata gcatcccagt
     9481 tccatcgctg tgtaggaagc ccgaaaatgc ggtacagccc cacattgtct atcagcatac
     9541 acgcctcctt gccctccgat ctccgcaatc cgcgccctac ctgctgcaaa tatttagcca
     9601 gtgacaaagt aggacgggcc agttgtacaa actccacatc gggacagtcg aacccctcgc
     9661 tgaatacatc cacattcacc agcacctcga tttttccatg tctgaactcc tccaccatcc
     9721 gcttacgctc catagcagga gtcttgctgt ccacagccac cgcattcact ccccgcctgc
     9781 tgtaatactc cgctatccgc cgggcatgtt caatgctgat ggcatacacc atccccttct
     9841 tgccggaagc aaactgcctg acactgcggt acaggcgctc gataccggga cgcctgttca
     9901 gtaccgcatc catctctttc acctgataat ccccatcggc cccccgtttc tccagaccgt
     9961 caatgagccg ctgctcctcg ctgccgggac ggatggatac ataatcgaac acagacaaca
    10021 cgcctttttc aataaactcg gcaatactcc acgaagtaac cagtacctcg aacagttccg
    10081 tgaaccccct acggttcagg cggcaaggtg tggcagtcac acccagtttc tttgcggcag
    10141 gataacgctt ccacatctcc gtgtaagaag cggccaaggc atgatgagcc tcgtctatca
    10201 caatcagtcc cggagcatca cccgcctcat tccagtgccg ggacagccat tggacagaca
    10261 tcaccctgac cggagtatcc tccctccgga taccatattt agccagcgtt tcctccattt
    10321 gcgccaccag ttccctacga tgggcaataa gccatacccc gctgccggca gaagacacga
    10381 actcactgac cacagatgcc agcaaatgtg tcttgcccgt accggtaggc atctgcacca
    10441 tcacactccg gtgagctttc cacgcttcca tcagacgtgt tttcatctct atctgataat
    10501 cccgcaacat aaataatttg ccgatttgct aacgtgccaa tggagtaaga ggataactga
    10561 aaaaattatt tactagccag catattatta atctgcgccc gtatattggc tatcgtaccg
    10621 cccgacacaa gccgtttggc aaaaggtagc aacgacttga tgaaagccgc tttcaccacc
    10681 gtgtgtttgt ctacattcct acagttctca tcggccagca tctttcctac caccaccgcc
    10741 agttcgcgtg ccgtggtaca ctctccccaa agtatcttgt aagccctcat cacctttata
    10801 tcgggtatat agaccgatac gtaaaattca tcatccgaca gttccgccgg ctcctgtgcc
    10861 ggcttctcat ccgtcacact ttctgtactc tccgttttct cagaaccttc cggttggtcg
    10921 gcggcctcat caccccggtc gccataaaag ttctgaatgg cggaagacgc cacaggggca
    10981 atcagattgt ttccgccata aatatttatc atcatatcag gtttttcatt catatactat
    11041 ttcttttctc tattctttaa ttattatcaa cagatcgtta atcaaaatcc atattttatc
    11101 aatatataat caatagcatg caccaatagt aaacagatag taaacggtta tgaaccgatt
    11161 tccatacgtc attccctacc cgtatatttg tgcagataaa tcaaaatcaa tttcttttat
    11221 gaaagaatac atcatgtcat ttttcaatgc acccgtcacc aataaaatac ccacatgtat
    11281 atgcagtgtg gcagggcttc atacctacat cagcaccaat ccgcaactgg aagaactgac
    11341 gcgtaaagtc agagccggac tcggaaacaa gcaagtgttc cgaaagaata aacagaccct
    11401 tttaccgtat gtcactccgg caggtatctt ctcttactgc aaagagcaat gcatgcaagt
    11461 tccttcgggc ctctttgtca tagatattga cgaactggct tccaccgaag aagcggcaat
    11521 gtggcgcgac cgcctctttg ccgatgaagt gctgcacccc gtactttcct ttgtcagccc
    11581 cggaaaccag ggagtaaaac tgtttatccc ttaccgcata aaccctttcc tgagcgtgga
    11641 agaatccttc gacaatgccc tgcacaccgc atgggagtat ctggaatgga aatacgagct
    11701 gaaagtggac agggccaatg ccgacttgtc cagagcctgt tttctgtcgc acgacggaga
    11761 agcgaaaatc aataaccata aatattaaaa aatgaacgat tctatttcta tcttggaaca
    11821 gctggtaaca gccatcgaac aagcgggagt caatgtggcc cccacctatc aggaatatat
    11881 gccgctggcc tttgccatag ccaacagttg cggagaagaa ggacgcaccc ggttccaccg
    11941 catctgccgc atatccgaaa agtaccacca cgatgaagca gacaaactgt acggacatgc
    12001 cctgaccaaa ggaacaggca gaaattccct gggaaccgtc ttccatctgg cagaggtggc
    12061 cggggtgaaa atggacccga aacttgcaaa cttgcagaac ttgcagtctc tccacaccca
    12121 cacacgtgcg cgcgtatcct ataatgccca tctggatgct tccgacggga ctccgcccga
    12181 tgccgttttc acggacccag cctcccccct gtccgacggc gtgtccaaga ccatcctccc
    12241 tgcccgactt ccctatttcc ccgactaccg ctggcccgcc ttcctgcaag gaatcataga
    12301 ctgcggtaac tctcccgccc aacgggatat cctgctgctg ggtgcggcaa ccgtgctggg
    12361 aagcaccctc aacaaactgg taagttttgt gtacggacga aagcacaagt atccctgtct
    12421 gcaagtattc gtcaccgcgc ctcccgcttc cggcaaaggt gcgctgacct gggtacgccg
    12481 tttggcagaa cccatacaca acgcgctgct ggacacctac cgggaaaaaa taaagaccta
    12541 ccgcatggaa aagaccaaat gggacacttt ggggaaggaa aaggcaaata cccccgaacc
    12601 cgaacagccc cagctgaaaa tgctcctcat agccggcgac aataccggta caggcataca
    12661 ggaaaacctg atggactccg gaggcgtagg actgatatgc gaaaccgagg ccgacaccgt
    12721 gagcaccgcc attggaggcg accacggaca ctggagcgac ctcctccgga aatgtttcga
    12781 ccatgaccgg ctggcctaca accggcgcac caatcacgaa taccgcgaat gtaacgtcac
    12841 gttcctctgc gtacttctca gcggcacgcc tgcacaaatc aagcccctta tcccatcggc
    12901 cgaaaacgga ttgttctctc gccagctgtt ctactatatg cctgccattg aagaatggga
    12961 agaccagttc aacgaagcgg atacagacta tgactcccgt ttcctggaat ggggggcaca
    13021 atggaaagaa gtgctggacg ccatcaccgc ttcggtgagc aacatcaaca tgaagctcac
    13081 ccacgagcaa aaagagatat tcaacttcca ctttgcccgc gtattcggac gagcctccgc
    13141 cattcacggc aaccagatga aaagcgccgt aacccgtatt gccatcaata tcttccgcat
    13201 cataagcatt atcgccctgc tgcgctctct ggaatccctg ctgccgggag gcgaaaggag
    13261 cggtgaacca caggaaaata tcgtgcgtac cctgctgaac tgtcccggac tgaccccgtc
    13321 ggcccatatt ccacaagaaa acatagcaga cggaatcgta ccgcaattca acctctccat
    13381 ccgcaccgac gacttttatg ccgtgctggc cctggtggaa cctctgtacc gccatgcatg
    13441 ccacattctc tcgctcctgc ccgcaggaac ccccaccgca ccatcggcga acatgactcc
    13501 cgaaaccctg ttcgactgcc ttcccctgcg cttcacccgc aacgaagcca tcgacaaagg
    13561 agaacaggta ggagttccgg caggctcggt ggactcgctg ctgaaacgta tgaccgaacg
    13621 cggacagctg gtcaaagtgg ggcgtggcga atacgaattc aacgcgcgca tgcacacacg
    13681 tacgtgtgtg ggtgtgagag agagtgcaag ttctgcaagt ttgcaagatt cctgaattta
    13741 aaatgtataa atatgaaaga tttcctttat ttcccatcca tgacaaaagg tagcctggct
    13801 ctgctctatt ttcccggttc aaatccccgg atagccaccc ggcatctgat gaggtggata
    13861 aacggctgtc cccctttgat ggaagagtta tccgcaacgg gttaccatac ctcgcaaaaa
    13921 gtcttcacga gccgccaggt gacactgatc aaccggcatc tgggcagccc cggatagccc
    13981 tgcaagctct ttggaacagg atgaaagcca taaagtgcca caaggtgtca taaagcgtca
    14041 gcacgcattt cacagtacct atctttgcaa tgtcaacaat gagggagccg atacgttact
    14101 aaccttcggc ctagcatgtt actaacatgt aaccctatac gttactaacc ttcagcctta
    14161 cacgttacct acgtgcaatc cgcaagaaaa gtaaagtatt ctccctcttc actgacgaaa
    14221 ttcatttttt atttttcatc tcttaaaacc ctatttatca tgatcaacta cagcacctgc
    14281 atgcgtggta accccaccga caaagacgcg gccaagaagg cgtatgccaa cgcccagtac
    14341 tcacaagtaa tgacactgga caagttctgt taccacattg ccagccacgg atgtgtatac
    14401 tcgcgcgccg atatccaagc catccttatt cttgccgtgg actgcctgcg cgagcagttg
    14461 ttgaacggac agcagataca gatgggcgat ctgggcgtat tttcgaacag tatccgaagc
    14521 ct
//
