LOCUS       gnlProkkaKDBFDCJD_45   13963 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KDBFDCJD_45.
ACCESSION   gnlProkkaKDBFDCJD_45
VERSION     gnlProkkaKDBFDCJD_45
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 08:23:28
            Original ID  :: gnl|Prokka|KDBFDCJD_45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13963
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13963
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3257:3963]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3258..3963
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..13963
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13963
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             3..326
                     /locus_tag="ctg45_1"
                     /transl_table=11
                     /translation="MFLTTFNGPVHSFTVDRGTEFSGLVSLESQYGIKTYYCHAYTPAE
                     RGSNERFNRNLRYFYPKGTRFEHISAQDLTTTLLQINQRPLKILDWQTPYQVMLTNLSK
                     NSD"
     CDS             complement(457..894)
                     /locus_tag="ctg45_2"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(1250..1993)
                     /locus_tag="ctg45_3"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(1986..3248)
                     /locus_tag="ctg45_4"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(3258..3386)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_5"
                     /sec_met_domain="TIGR04223 (E-value: 1.6e-08, bitscore:
                     25.3, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             complement(3367..3963)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_6"
                     /sec_met_domain="AgrB (E-value: 1.3e-35, bitscore: 113.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IETGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(4331..6445)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     962; E-value: 4.2e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRSTGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEATKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(6836..7069)
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(7515..7868)
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRVPTI
                     FDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQLAG
                     TKTLIDELKLCRR"
     CDS             complement(7881..8612)
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWNFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIIEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQ"
     CDS             complement(8639..10387)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 471.4;
                     E-value: 6.7e-143)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_11"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-41, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-32, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDHLK
                     YIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVGQS
                     ATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVIIPD
                     DLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQEV
                     IAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNFPF
                     ARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAAQR
                     DKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLNKQ
                     QTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPVIN
                     VVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQKV
                     TQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPALS
                     QLLNEL"
     CDS             complement(10475..10900)
                     /locus_tag="ctg45_12"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             complement(11073..12884)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 494.2;
                     E-value: 8.6e-150)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_13"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1e-44, bitscore:
                     142.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-38, bitscore:
                     123.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLTPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSATSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
     CDS             complement(13255..13629)
                     /locus_tag="ctg45_14"
                     /transl_table=11
                     /translation="MTKERIIFSTKVLEIGAESADFKSIGMAVLFGDEAPDALRPSCFI
                     IEVVPISEQITAGMKLEVDNQVYQITAVGGEVQTNLGRLGHTAISFTGAKEAKLPGTLY
                     VEQGDYPDFKVGSVVRIIAE"
ORIGIN
        1 ctaagttcct aaccactttt aatggtccgg tgcacagctt tactgtggac cgtggcactg
       61 agtttagtgg gctagtatca cttgaatcac aatatggtat taagacctat tactgccatg
      121 cttatactcc agctgaacgt ggtagtaatg aacgctttaa tcggaattta cgttattttt
      181 atcctaaagg gactcgtttt gagcacatta gtgctcaaga tttaacgacg acgttactcc
      241 aaattaacca gcgaccgctt aaaatactcg actggcaaac accgtatcag gttatgctga
      301 caaatttgtc caaaaattcg gattaaattt gcaatctacc ataaagaatg atgatgccgt
      361 ctcatggtta ttaactaaag agcgacaggt tagactcata tcgtgtaagt ctagcttgtc
      421 gctctttaat taacaaaaaa tcttagatat agcttactac tcgaccatcc ttttattaat
      481 aatgtgatcc cctgtattac catctagacg actcaacaat gcattgaact ttagtcgccg
      541 aactggtcgt ggaataaatt ggcgaatatc atcttcatta aagccaactt gaattttact
      601 atcactaatg atgataggcc gacgtaacaa cttcggatga tcacacaaca atttaagtgc
      661 ctcattcaat ggcatttcgg gtaacttagg cgcaatttca ggatagtctt tagatcgagc
      721 tgagataata tcgtctacac catgttcggt taaactcaaa atacgtttta gatcttgcac
      781 cgtgggcgaa tcaacactaa aatttttctc cttgaactca atcccatgtg cttccaacca
      841 ttgccgtgca actctagaag aatgacagct tgattgtgta tataacctaa tcattcctaa
      901 tctgcccctc tctcgttaaa attcatcaca gcgtattgat cgacattaac ttctgcctgt
      961 cacaacatcc tttaaactaa acgcattcgt tactgtcatg accaatccaa taccccgtga
     1021 acacatcttt attataggct ctgaacaagg gacataccga ccgttttaag acgaataatc
     1081 tgaggataat cgttttaagt acacttttaa acggtttagg aaagaacgaa cccagtacac
     1141 gtaatgctaa caaatatcac tgcaatttct aatcgaataa cgctgaattt tcatcgcgta
     1201 gcacataaaa agtcgcctac taatttaaca ggcgacttcc ttggaactat tatgactttt
     1261 tagcaagcca tttagctaga taacgattag cttgtgcaga acaaagcact ttttcaccat
     1321 ttgtcatggt taatcgtcgc aagtgcttgt ccaatgactt aatgcgtttc aagttaacaa
     1381 catatgactt atgacaccta tagaaattag gactcaaatc aggaacgtcc tttaacagtc
     1441 catagtattc taattcacca tcatccaaat ggactacgat tttatgggga ctggttgaac
     1501 tttcaaaaaa tataatgctt ttaacattaa ttgatctgac cgtctcacca atttttattt
     1561 gaacatagtc gtcttggtca ttttcatcgg tttgaaaacg atcttgcgcc acgtgtaaaa
     1621 ccttgctaaa tcgctcatac aaggaatctg gaaaatcctt aagaataaaa tctaatgcct
     1681 caacttgata ttgaaacacc atcaaagata actccgtgtg tgtcgtgata aaaataatct
     1741 tgctgcgacg gcccatgtca cgaatctggc tagctagttg aataccatta atatctgaat
     1801 taagggcaat atctaacaca tagattgcct tttgaggctg ctgtgcatta accttgtcta
     1861 acaattcgtg gggatcttgg catgctaaac agatactcat gtctagctgt tgatcgacga
     1921 ttaccttagt aatgatttgc cgtatttgtt gtaattgttt cggatcatct tcgcaaatgt
     1981 agacactaat cattctgaga tactcgcttc accgtcaagc gttgtaagaa taccgctcct
     2041 aagactctgg tttcgagtat catgttctca ttgcgattaa caatcttact taaactattc
     2101 aatccaatcc cccgattctt gcccttagtg gaataacctg cctctttcag cttccataag
     2161 ggtggtaact gttcaaaaac attgttttga atcaagaaca ccgtactatt tttttcgata
     2221 aaaatggcac tcataatctc tccatcagca tgtcctaccg atgcttcgat tgcattatcc
     2281 aacataatcc ctaatgcaat gtctaaatcc aattcattaa cagtaatgtc aattaatggt
     2341 tcctttaaat caaaatgaac ttcaatctct tgcgattgtg catagctcaa cttactaaat
     2401 aggatactct taatcgactt cactttgacc cgactcaaat cttcaagatt atatttttct
     2461 tttaacaccc gatttgaaac cggtgcaaga ttcttttgat aatattcttg taaaccttct
     2521 aaatcatcag ttttcaaata ttcatctatc gaaatcaaca tattctgata gtcatgtctg
     2581 aaacgtcgca actcattata gtgagcttcg atttcattca tatagcgagt atcattttgt
     2641 atttgtattc tttgcttttg gacttcatat ttggctctta cattttttaa atattcgtta
     2701 taaatcacca atactaaccc cattacaact gacaatataa ttaaattact taatataacc
     2761 tggaactgat tttccagacc ttcactcaac ataatataca agtatattat cattaataat
     2821 agtgcggtta tgcgatttaa gctctgatta ctaaacgtgg gactgaaatt cgtgcgatcc
     2881 attacaatat taagaaaaat taagcttacg acactcaata tgacaaacac taccacatac
     2941 ccattaggaa ctttcattaa acgagttaat atatcacaaa tatggtcaac cataatcgac
     3001 catatgaaca cttgaaatgt tatacatagt gcaccgctta gaactcgtac ataccaccaa
     3061 gtgaaaaata taaacatcat taacattaaa aaagaaaaac taattcctaa ctttgctaaa
     3121 aaaatataac tcatcagcat acagacggat aagaatataa catcaaaaag tctcacaaaa
     3181 aatatatttc tcaacaaaga tttaattatc aaatagatag ataattcttg gaagacaatc
     3241 attaacatat atctacacta atccttgctt tttaattcat caggaatttt agtttcgaat
     3301 aatatcccat ggcagcacat aaccaactgt ttagtaccta cgtattgaaa aagatggcta
     3361 agtactttat acattttttc tttcataatt ttccctcctt tcatagggca ttagtaataa
     3421 agcggctaat gccatcgcaa ttaaaatgat tgtgccaaaa taattattac taactatttg
     3481 taacaaactc aaaattaatg acaatccaat tgcccgtcgc tttaattttt ttctcaatga
     3541 cttcgatgta ataggattct ttaccgtatc agctggagca aaaatactta tgattattac
     3601 aaatattaaa cttaataaca atctgtatac ttcagaaata ccagtttcaa tcacatacgg
     3661 cacacccaca aacacaaaga tagttaatat cgtacataac aaatccgatt tcaagtgacg
     3721 tccataggca aagccacgca aaactaaaaa actacccata aaaactaaca ctgggaccaa
     3781 ctcgtgtagc agcaacgcta agataatagt aattatcagc ttaggaataa catttaatac
     3841 agtatcaatg cctagtttaa ctagtaatgc ctgccgtctt tctagttgaa gattcttttg
     3901 aatcgcagcg aataaccgat cgcttaattt ataaagcaat agtttttgtt ctggcttttc
     3961 catatcccac tcctataatg ctcaaataca tacctgtatc aacagtttaa aacagtatta
     4021 attaattgaa aagaatacat aaatatatta attattcaat attgttttaa gactagaaat
     4081 aaacatttaa agatacatca gtttaattat tcatacgaaa ctaaagtttc atgtaaaaag
     4141 atcgttaata taaatcagtt tcatcgatac tcccccttaa tttttcctta gattacaagt
     4201 caaactagac ttaatttcac taattcacat tactcaatag attaatatca aatggtgaaa
     4261 atcaacgaaa agaggagatc tatcaagcaa tctcctctta cataaagtta tttatgaaca
     4321 ctgatttaag ctaagctgcc gatatcacaa tctcagcatc cactaaatca gccttcaagt
     4381 ttttgacatc taagtggtca aggtagaaat ccgttacctt gtcacgaatt tgttgttcaa
     4441 ttactcgccg taatggccgc gcacccatcg cttcatcata gccttgttcc atcagccaat
     4501 ctttggccgc tttagttacc tcaagtttga tggatttttt ggctaacgtt ttttgtacat
     4561 ccgccaacat caaatcgaca atttgactta agtcttgctt agtcagatgt gaaaattcca
     4621 cgattccatt aaaacggttc agaaattctg ggcggaaaaa tggtgctaac ttatccatta
     4681 atgactgatc tcgttgcttg tcaccactta atgcttcatt accaaagcca gcattagaag
     4741 tagcgataat aatcgtattt ttgaaattaa tgacattgcc ttgtccatcc gttaagcgcc
     4801 catcatccat cacttgtaac agtaacgtta atacttgtgg atcagccttt tcaatttcat
     4861 ctaataatac aatggaatat ggattacgcc gaacccgttc ggttagagta ttagcattat
     4921 cttcatagcc tacgtatcca gccgaggtac caattaattt cgacacagct gtacgatcag
     4981 catattcact catatctagc cgaataatcg catttttatt tccaaacata tctaaggcta
     5041 attgcttagc taattcagtc tttcctacgc cagttgggcc cacaaacaga aaacttccaa
     5101 ttggctgatc accctctgaa aagcccgcac ggttacgccg aattgccttc gctaccattt
     5161 caaccgcttc atcttgaccg attaccttac ttttcagacg cttatcaaga tttttcaagt
     5221 gctcaatatc attagcgccc atatcagcaa ctggtatacc agttaaacgt tcaaccgatt
     5281 gtgccacatc atcaatcgtg gcagtgattt tttctttttg atccgttttt ttaatttttt
     5341 gcttggtttc ctcgatcgac ttcttgatat cagcggcttt tgtaaagtcc tccgatttaa
     5401 cggcggcctc cttagttgcc tctaattttt taacgcgttg atccaatgtc tcaacatcag
     5461 tttgcgaatt tttagccgct aaatgagccg cagtcatgtc gatcaaatcg atagctttat
     5521 ctggcaaagt gcgttgtggt atatattgga ttgaataatc cacagccgcc ttcaaaacat
     5581 catctggtaa tacaacatga tgatgctttt cgtacagctt tttaacacct tgtaatatac
     5641 gtaaagtgtc agcggccgtc ggttcattaa tcacaacatc attgaatcgc cgtgccaaag
     5701 ccgcattttt caaaatagta ttgcgatatt catcttgagt cgtagccccg attacagtca
     5761 gctcgccacg tgacaaagca ggtttaatga tatcagccaa tcctttgcca ccatcttcac
     5821 caccagtggc gcccgtgccg ataatctgat gaatttcatc gaagaataga ataatattac
     5881 cagctgcttt aacttccttt actagctgtt taatattttc ttcaaaagaa ccgcgatatt
     5941 gagttcctgc ttccaaagac gataaatcaa tcgaatagat ttctttatct tgaatcgttt
     6001 ctggaacttt accagccaca attgcttgtg ccagaccttc gacgactgca gttttaccta
     6061 caccagcatc accaactaag attggattat ttttcgtcct acgactcaaa atttctgcag
     6121 tttcttgaat ctcattctca cgtccaatca ctggatctag taatccatca cgagcctgtt
     6181 ccgtcaaatt agtccctaac ttttctaaaa tccccccttt tttaacagcc tgtttaccat
     6241 ctttagatac ttctattgtt ttattatttt ggggtagctt accagttgat cggtattgag
     6301 caaactcatc cggtgtcagc gattgtccat taactaaata ccgtgcacgc tccgaatttt
     6361 gattatccat gcgccgaaat aattgattga aaacatcatc catatcattg ttgaaaaaag
     6421 gatcatttcc gtagaaattt gccatattac aacacctcca taaaaattta tatgtgtaac
     6481 ttagtgacca taatatcctt taaaactaca actgaatcgt atcacgattt ttatgtatcg
     6541 ttaagtaaag tgcttataga atcaattaga aataattaga ataattttgt ttaaacaaaa
     6601 gagaaatcaa tttcataaaa tgaattgatt tccctacaag gttccctatt taatagccct
     6661 tgataaagaa cttgaattaa caagttactt tccagaccaa ttttaattta agagactgcg
     6721 actcaaaaag cacacccagt atcaagttaa ggccaactag ttatcgttaa tattgccact
     6781 taaatatcaa tactagcaat catgatacac gtgtaaaatc ataaaccaaa acatattaca
     6841 tgacgtaacg gcggtcttgg gactgtaaac tcacagtaat gattctattg agttggataa
     6901 ggtgccgatg accagtaatt gccataaatg caattgcttt cggtacaatc gtagtgacat
     6961 agccaactgt ctcggccatc tgcccatttg ttttataaaa ccgtaatgag actcgacatt
     7021 tttgatcatg cgcttgttgt aatttacaat aattattttc aacactcaaa ttaaagtctc
     7081 ccgttcaaag aattcaggtt tatttattcg tcagtgaatc tatgtgtttg tttttctcat
     7141 tgttgacggc gtaagtccac attaaggagt cagctattca gtaaaaacta aataactagt
     7201 attcatgttc agctcagtat aatatgcatt gatggttact aatcaaaaat cgatctctaa
     7261 atatcctaat tactatgaaa ctttgaagtt aatttatgag aaaaataact cacaacaaaa
     7321 ctcatgatta caaccttgtc atcataacta gattatgaaa cattcagcct cctaaataaa
     7381 actggtatgc gcgcatgtgc gcatgtgtac agtatactat tgccaggtat gtctgaataa
     7441 ccgttttaag acttgaaaaa ctcagctggg tgctttagga cgctttttgt gcattttaag
     7501 acaatatcct aacttcaacg ccggcatagc ttcaattcgt caatcagtgt cttagttccc
     7561 gctagttgca tatcgatcaa cagctcatca ttaaggtgac tcactacgga agcgacaccc
     7621 tgcgcaccac ccaatgctaa tccatagata atcggccgag caagtgccac cagatctgca
     7681 ccattggcta acgccttaaa gacatgggag ccacgccgaa caccgctatc aaaaattgtt
     7741 gggacgcgcc cattaacggc ttgcgcaatc tcgtgtaaaa catcaaagga agctggacca
     7801 ccatttaatt gccgaccgcc atggtttgaa acatagatac cttgagcacc agccccgatt
     7861 gctaacaagg catcttctgg ttactgaatc cccttcacaa taactggtaa attcgtatat
     7921 tctgtaatac gccgaacatc agctgggcta atcttttgcg ccgcagcagc atagatttct
     7981 atgatacctt tccctttacc atccccttcg ctgaacttag tcaagttagc cattgggatt
     8041 ggaaactgga aattgttgat aatatcagct tcacgatacc cgtcaactgt tgcatcaaca
     8101 gtcaaaatga ttgccttagc accagccttc actgcttcat ccaataaact ctgattgaaa
     8161 ttccaatcct tgctcatata taattggaaa aattggggcg cacctttacc agctgcggca
     8221 gtatccgcaa ttgacgttga agaataagta ctctgagcca tgagtgcccc aacttgagcc
     8281 atcccttcag cagtcgcagc ttcaccccgt gcatgtgcca atccttgagc ggccgctgga
     8341 gccatcataa taggcgtttt gagatctatg ccaaaagcct gagtctgtgt gcttggctgt
     8401 tccatatccg tcaatgctcg tggcacaatt tgaacatggt taaaggccat tgtattctgc
     8461 tttaaagtcc attcgtcttc tgacccacca ctaatatagc caaagcctcc gctcgggatg
     8521 atctttttag cagctgcttc caatgatggt aaatttaaaa tcgttaactt ttgctcacga
     8581 tcactctgtt catatccatt aataactgtc attatactaa tctcctttac ataacccttt
     8641 ataattcatt taataattgg ctaagtgccg gttgatccgc ttcagcgata ccatatcgtt
     8701 cacgatactt agcaatcgta tctgcatcaa agttttctgg atctactgga acaaaactag
     8761 tatcaattgg atcaacattt ttaatttttg catcaatcac aattggtagt tgattaccat
     8821 tctgctgtag ttgagtaact ttctgaaacg ttgctttcaa ctctttaagg ttagtcactt
     8881 taaaaccaat cgcacccatg ttgtctgcca tcttggccca atcagcacca atcaagtcaa
     8941 tcccatacgg cgcctgatta gcgagtaact tttcatgttg aataaagcct aatactttgt
     9001 tttctaaaac cacgttaatg actggcaaat gatatttaac ttccgttagt aagtctggca
     9061 tcaccatggc ataaccacca tcaccagaaa tactccaaac ctgcttctta ggataattca
     9121 attgggcggc caaacctgct ggcaaaccaa aacccatcgt gccataccaa gccgacatcg
     9181 taaaagtctg ttgcttattc aatggtaact gtcggattgc ccattccgta ttattcccaa
     9241 catccagacc aaagacggca tcatcagtag cattgtcttt aatagcttct agcacccctt
     9301 cagccgtcaa ccctccttga tcatcagtag caattgtctt gagccaccgg ttccagtttt
     9361 gcttatcacg ttgagcagct ttcaagaact tagttggctt aattgtcact tcggattgaa
     9421 gtaatgcttg gaaaaattct tttgcatctg caagaacagt aatatcagca tcatgttgtt
     9481 tgcctaaatc tgctaaatta ttattgactt gaataaactt aattccttgt ggcaagtaac
     9541 gtgcaaatgg aaagttagta ccaacaaaca aaactagatc tgccgcttgc gagacttcaa
     9601 aggcgggttt agttcctagt cgaccgcgag agcccatgaa attaggatgg tcagttggca
     9661 taataccagt tgctggagcc gtcgacaaaa ccggcaaact aaatttttca gaaactgcga
     9721 taacttcttg acgcgcatta taggcaccct tgccaatcca taaaacaggg tgttgagcag
     9781 ctttcaaagc cgctatcgtc tgctgaacgt catctaattt cggcattaag acctgttgac
     9841 tgccgctaag tgaagccgtt ttaaaaccat caaactcaat atcttgacca gacaaatcat
     9901 ctggaataat aacaacagaa accgaacggg tcgcgtatgc tgatctaatt gcttcatcaa
     9961 ccacgtatgg aatctgttca gccgttgtca cttgtttatg aaattcggct acatctgcaa
    10021 aaattggatc ttggttcatt tcttgaaaga agttcgtatt cataatggat gttgctgatt
    10081 gaccgactaa agctagcacc ggtacgtgat ccatcttggc atcgtataat ccgttcaaga
    10141 gatgaacggc gcccggtcct gctgaaccaa agctaacacc aatcgtccca gttaatttag
    10201 catctgccgc ggcagctaaa gcaccaactt cttcatgacg tacttgaata tacttcaagt
    10261 ggtctttctc ttggtagaac ccatctaccg tgttattaat cgagtcagct gtaataccat
    10321 agatatgatc aatgttccag tcgactaaca cttgtgccaa tgcttgtcct gctttaattt
    10381 tagtcatttc cattaccctc tttttgttgt tacttttttg agcacaacta tatcctaaat
    10441 aaaaacttga cccttgtcaa gtctttatct taaattatgc ttgttgttga acagcgctaa
    10501 tgtcatcaat aatatcttgc agcgtcactc gcgacatacg tgcctcagca ctattctgaa
    10561 tatcacaata gtatttttcc atcactcgcg gaattaccga cccgaccgga cacgtctccg
    10621 aagtattatg atcaacgttt aaaaaattac gcttagccac cactgctaca tagatatctt
    10681 tcaaggtaat atcattgggc gaacaagcta atgttggtct agcaacgcca cgaaccgaag
    10741 ttaacaagcc tgcttttctt aacttactca tcattcttct gaccatggta ggatccgtat
    10801 ttaaactact agcaatatgc tcacttttca gctggtcatc agtatgcaac gcaatatatg
    10861 ccataatatg cgtcgcatca cttaattgtg tattagccat ctagacacct cccatatcca
    10921 tctctattgt tacttatttt agcacatcta acatgaacat aaaagcgatt aaggaaataa
    10981 gttaggcttc tttccctaat cgcaacataa gattatttga taatctccat taattcaatc
    11041 aaacttattc aagacatcga tagtagctga atttaaaacc caccctgtcc aatttgatgt
    11101 tgcaaatcat ctaagccaaa ttgttttaaa taagttgaaa gtggttgtaa atcttgagct
    11161 tcataccgtt gtttaaatgc ttcaatatca gctgccgaac tcgttgccga atctaaacga
    11221 agcttttcag caggcagtgg ccgatctcct gtaatcaccg catcaatcag aactggttca
    11281 tgctgagcga ttgctttggc ttgttcaaaa acatcaggta attgctcaat cttattaact
    11341 cgaaaagctt gcatgtgcac gccatcggca atcttactaa aatcaatatc attgaattca
    11401 acgccaataa aatcattctg attagtatct tcctgctcat ctttgataaa tccatattgg
    11461 cagttggtga aaacaacatt aatcactggt aaatggtatt gaacttgcgt cgccaaatct
    11521 tgcatggtca tcgaagcgcc accatcaccg gccagattaa acacctgccg ctcaggataa
    11581 ttaagtttgg cagcaattgc tcccggaata ccaactccca tcgtagcaaa taagttagaa
    11641 gtaatgtgcc gattggacgg cgttaatttc aaatgtcgat tcgcattcaa attgatatca
    11701 ccaacatcaa tcgaatagat tgcatcaggc tccgcaattt tattaaccgc acgtagcact
    11761 tgatatgctt gtaaaggccc ttcctgctta tcttctaatg aagctagata agcccgccaa
    11821 tttttaacat tggctaaatt ggcttgccac caaggtgtcg actcccgttc agatacctgt
    11881 gctaaaattg cagccagcgt tttttgtgca tcagcaagta ccgcaatatc tgttttatgt
    11941 cgtttaccta acttagctgg atcaatatca atttgtaaga aataacgcgt atttttaaac
    12001 gctttggaaa cttctgcaaa cggataatta ttaccaacaa ataaaacaac gtcggcttgc
    12061 gcaagtgcct cattcgccgg tttttgtgcc acccgattag cagaacccaa ataggctgga
    12121 taacgatccg cgacaatacc cttagctgga tacgtactca ttaatggaat tttcaacgtt
    12181 ttactcaatt gttcgagttc tttaccagcc ttacgagctc caatgccata gtaaataagt
    12241 ggccgttcag ctgcgagtaa agtctgtgtc aatctcgtca ctgcttgaac gtcgggttct
    12301 ggtaataacg gcgtttgata actattagcg gaagcatacc aatcttcagc tggaatctgt
    12361 tgccatggta aatcgactgg aatttgcaca accgcaacac cttggtgcgc gtaggcgcgt
    12421 cgaattgctt cgtcaataac atgtggcaac gtggcagcat tgacggctgt tacattataa
    12481 tctgcaacgt ccgcataaat cggattctca ttcatttctt ggaacgtatc catgttcatc
    12541 ccagtagttc caaattgacc aataagtgct agaacaggga catggtcttc acgcgcatca
    12601 tataacccat tcataagatg agtgccacca ggtcccgctg agccgaagca aaccccgatt
    12661 ttacccgtta gcttagcatc agcagcggcg gccattgcac caacttcttc atgccgtact
    12721 tgaatataat ggattcgatc cctttctgct gataatgcgt ccataattga attaattgaa
    12781 cctccaggaa taccatacaa atgatctact ccccaagctt ctaaaacttt aataactgct
    12841 gcacctgcta gtatgttagt ttgttttgtt tgtttcataa ccataataaa gcccccattt
    12901 catgcacaat ttaattacgc acaatttaat aaacgaatat taccatagca aacgcttaca
    12961 ttcaagtggt cataaactca tgctttttac cacttaatca cgattcaaac gcattgtaga
    13021 tcaacaacag cgctagtctg cttgccttga tgaaccacca tcgctgttga cagttagtat
    13081 ctcatacatt cattttttaa acaattttag taattagtgt atgttttaca ggggcatact
    13141 tccaacaatg tctgcatgtt tagaagctag ccattcttcg aaaactaact accgctttca
    13201 aaacatgacc ttaactcaac tcgacacaga gcaaaataac atctgccaag ttaattattc
    13261 agctataatc cgtaccacgc taccaacttt aaaatcagga taatcgccct gctcaacata
    13321 taacgtccca ggcaatttag cctcctttgc acccgtaaaa ctaatagccg tatggcctaa
    13381 tcttccaagg ttagtctgga cttcaccacc aactgctgta atttgataga cttgattgtc
    13441 gacttcaagt ttcattcctg ctgtgatttg ctcacttatt gggacaactt cgataataaa
    13501 gcaagaaggc cgtaatgcgt ctggagcttc atcaccaaat aatactgcca tgccaatcga
    13561 tttaaaatca gcagattccg cacctatttc taagaccttt gttgaaaaga taattctctc
    13621 ttttgtcatc atacaataca cctcaaacct tctaaaaatt tattttgaat ataatccaaa
    13681 acttgcaatc caagcaataa agacccgcgg aacgccgttg ataaaccgac tatataacac
    13741 tgatggcacc ccaacttcaa ccgtcttaga atcagcctca gctagtccta agccaactgg
    13801 aataaagtca caaccatttt gcgtgttaat cgcgaataat gctggtaatg catactgtgg
    13861 tggaatatta cctttcccga tttcaacgcc aatcaaggtc ccgataactt gaccgataac
    13921 tgcgcctggc ccaagcaatg gagataagaa tggtaatgag caa
//
